alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with org 26576 in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banasr, M; Duman, RS; Henry, B; Koo, JW; Li, XY; Shahid, M; Su, XW | 1 |
| Brand, L; Hamlyn, E; Harvey, BH; Shahid, M | 1 |
| Bursi, R; Campbell, R; Dogterom, P; Erdemli, G; Hutmacher, MM; Jeggo, R; Kerbusch, T; Nations, KR; Schipper, J; Shahid, M; Spanswick, D | 1 |
| Jardemark, K; Malmerfelt, A; Marcus, MM; Shahid, M; Svensson, TH | 1 |
| Calabrese, F; Fumagalli, F; Luoni, A; Racagni, G; Riva, MA; Shahid, M | 1 |
| Adler, LA; Cazorla, P; Kroon, RA; Schipper, J; Shahid, M; Stein, M; Szegedi, A; Tarazi, FI | 1 |
| Bursi, R; Dogterom, P; Ereshefsky, L; Gertsik, L; Mant, T; Nations, KR; Schipper, J | 1 |
| Bursi, R; Dogterom, P; Ereshefsky, L; Gertsik, L; Greenwald, S; Johnstone, J; Lee, A; Nations, KR; Pande, Y; Ruigt, G; Schipper, J; Zraket, D | 1 |
4 trial(s) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and org 26576
| Article | Year |
|---|---|
Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.
Topics: Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Computer Simulation; Depressive Disorder, Major; Dose-Response Relationship, Drug; Humans; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Translational Research, Biomedical | 2011 |
A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Treatment Outcome | 2012 |
Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Depression; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Receptors, AMPA; Young Adult | 2012 |
Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.
Topics: Adult; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Human Growth Hormone; Humans; Hydrocortisone; Male; Maximum Tolerated Dose; Middle Aged; Psychiatric Status Rating Scales; Receptors, AMPA; Severity of Illness Index; Treatment Outcome; Young Adult | 2012 |
4 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and org 26576
| Article | Year |
|---|---|
Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antidepressive Agents; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Time Factors | 2009 |
The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats.
Topics: Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spatial Behavior | 2009 |
Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Catalepsy; Drug Synergism; Glutamic Acid; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Membrane Potentials; Olanzapine; Oxadiazoles; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, AMPA; Risperidone; Synaptic Transmission; Tetrahydronaphthalenes | 2012 |
The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Exons; Hippocampus; Male; Neuronal Plasticity; Phosphorylation; Prefrontal Cortex; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Stress, Psychological; Swimming; Transcription, Genetic | 2012 |