alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with kainic acid in 761 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (5.65) | 18.7374 |
| 1990's | 518 (68.07) | 18.2507 |
| 2000's | 167 (21.94) | 29.6817 |
| 2010's | 25 (3.29) | 24.3611 |
| 2020's | 8 (1.05) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A | 1 |
| Danthi, SN; Hill, RA; Layer, RT; Miller, DD; Shams, G; Tai, H; Uretsky, NJ; Wallace, LJ; Weinstein, DM; Willins, D | 1 |
| Brehm, L; Ebert, B; Falch, E; Johansen, TN; Krogsgaard-Larsen, P; Mikkelsen, I; Nielsen, B; Skjaerbaek, N; Stensbøl, TB | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Stensbøl, TB | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Rizzo, M; Stensbøl, TB; Toma, L | 1 |
| Armstrong, N; Gouaux, E; Mayer, M | 1 |
| Alt, A; Bleakman, D; Bortolotto, ZA; Collingridge, GL; Dolman, NP; Jack, S; Jane, DE; Knauss, JL; More, JC; Morley, RM; Nistico, R; Roberts, PJ; Troop, HM | 1 |
| Bräuner-Osborne, H; Brehm, L; Clausen, RP; Gajhede, M; Geneser, U; Greenwood, JR; Jensen, AA; Kastrup, JS; Kristensen, AS; Krogsgaard-Larsen, P; Naur, P; Nielsen, AS; Nielsen, B; Pickering, DS; Ringgaard, LM; Strange, M | 1 |
| Boschi, D; Clausen, RP; Farnsworth, JC; Hansen, KB; Jensen, AA; Kastrup, JS; Lolli, ML; Møllerud, S; Nielsen, B; Passoni, A; Pickering, DS; Sainas, S; Temperini, P; Yi, F | 1 |
| Madsen, U; Wong, EH | 1 |
| Beattie, DT; Bruhn, T; Curtis, DR; Diemer, NH; Ebert, B; Ferkany, JW; Johansen, JS; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Bregnedal, P; Brehm, L; Bøgesø, KP; Ebert, B; Frederiksen, K; Hansen, JJ; Krogsgaard-Larsen, P; Lenz, S | 1 |
| Ohfune, Y; Shimamoto, K | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Butini, S; Campiani, G; Christensen, JK; Coccone, SS; De Angelis, M; Fiorini, I; Gemma, S; Guarino, E; Morelli, E; Novellino, E; Pickering, DS; Schousboe, A; Trotta, F | 1 |
| England, PM; Fleming, JJ | 1 |
| Amir, A; Contreras-Sanz, A; Foti, A; Fruttero, R; Gasco, A; Giordano, C; Hansen, KB; Johansen, TN; Lolli, ML; Nielsen, B; Pickering, DS; Rolando, B | 1 |
| Greene, RW; McCarley, RW; Stevens, DR | 1 |
| Cox, JA; Seeburg, PH; Stein, E; Verdoorn, TA | 1 |
| Hong, JS; McMillian, M; Pennypacker, KR | 1 |
| Bloms, P; Madeja, M; Musshoff, U; Speckmann, EJ | 1 |
| Cotton, P | 1 |
| Ozawa, S; Takeuchi, T; Tsuzuki, K | 1 |
| Hansen, JJ; Krogsgaard-Larsen, P; Miledi, R; Nielsen, B; Schousboe, A; Wahl, P | 1 |
| Jonas, P; Sakmann, B | 1 |
| Bloms, P; Madeja, M; Müsch-Nittel, K; Musshoff, U; Speckmann, EJ | 1 |
| Donevan, SD; Rogawski, MA; Subramaniam, S | 1 |
| Maruyama, M; Nakazawa, M; Takeda, K | 1 |
| Haley, JE; Kitto, KF; Wilcox, GL | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC | 1 |
| Clark, B; Mobbs, P | 1 |
| Bobichon, C; Cordi, A; Curutchet, P; de Carvalho, LP; Guet, T; Lambolez, B; Lepagnol, JM; Moreau, C; Randle, JC | 1 |
| Andersen, CF; Frandsen, A; Schousboe, A | 1 |
| Bochet, P; Curutchet, P; Lambolez, B; Prado de Carvalho, L; Rossier, J; Stinnakre, J | 1 |
| Buonanno, A; Gallo, V; Hayes, WP; Upson, LM; Vyklicky, L; Winters, CA | 1 |
| Miller, DD; Uretsky, NJ; Wallace, LJ; Willins, DL | 1 |
| Fain, GL; Yazejian, B | 1 |
| Frandsen, A; Schousboe, A | 1 |
| Chen, L; Huang, LY | 1 |
| Bleakman, D; Brorson, JR; Chard, PS; Miller, RJ | 1 |
| Donevan, SD; Jones, SM; Rogawski, MA | 1 |
| Carling, RW; Donald, AE; Foster, AC; Grimwood, S; Kemp, JA; Leeson, PD; Marshall, GR; Priestley, T; Smith, JD | 1 |
| Abutidze, K; Ambrosini, A; Barnard, EA; Brackley, P; Henley, JM; Kerry, C; Mellor, I; Rodriguez-Ithurralde, D; Sudan, H; Usherwood, PN | 1 |
| McIlhinney, RA; Smith, AL | 1 |
| Johnston, GA; Maddison, JE; Watson, WE | 1 |
| Cha, JH; Davis, RE; Wilmot, GR | 1 |
| Kawai, N; Nakajima, T; Robinson, HP; Shimazaki, K; Takenawa, T | 1 |
| Balázs, R; Hack, N; Kumar, KN; Michaelis, E; Resink, A; Van der Valk, JB | 1 |
| Crawley, JN; Finiels-Marlier, F; Leppin, C; Montpied, P; Paul, SM | 1 |
| Parks, TN; Zhou, N | 1 |
| Dildy-Mayfield, JE; Harris, RA | 1 |
| Dure, LS; Penney, JB; Young, AB | 2 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Mishina, M; Nagahari, K; Sakimura, K; Uchino, S | 1 |
| Cai, NS; Erdö, SL | 1 |
| Chiamulera, C; Costa, S; Reggiani, A; Valerio, E | 1 |
| Dutton, GR; Rogers, KL | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| Bertrand, G; Bockaert, J; Gross, R; Loubatières-Mariani, MM; Puech, R | 2 |
| Lodge, D; Zeman, S | 1 |
| Oostveen, JA; Pregenzer, JF; Williams, LR | 1 |
| Hampson, DR; Huang, XP; Walter, JA; Wells, JW; Wright, JL | 1 |
| Davies, JA; Dickie, BG; Lewis, MJ | 1 |
| Baudry, M; Fitzpatrick, JS; Shahi, K | 1 |
| Bonhaus, DW; McNamara, JO | 1 |
| Gale, K; Miller, LP; Murray, TF; Zhong, P | 1 |
| Baganoff, MP; Davies, MS; Grishin, EV; Lanthorn, TH; Volkova, TM; Watson, GB; Wiegand, RC | 1 |
| Chalmers, DT; McCulloch, J | 1 |
| Bettler, B; Egebjerg, J; Heinemann, S; Hermans-Borgmeyer, I | 1 |
| de Barry, J; Gombos, G; Viennot, F | 1 |
| Barnard, EA; Bond, A; Henley, JM | 1 |
| Albensi, BC; Artman, LD; Jackson, H; Jasys, VJ; Mueller, AL; Nemeth, EF; Parks, TN; Saccomano, NA; Volkmann, RA | 1 |
| Harabayashi, M; Kushiya, E; Mishina, M; Mori, H; Nagahari, K; Sakimura, K; Uchino, S | 1 |
| Jones, MG; Lodge, D; Palmer, AJ | 1 |
| Henley, JM; Johnston, GA | 1 |
| Supko, DE; Uretsky, NJ; Wallace, LJ | 1 |
| Johnson, BG; Monn, JA; Schoepp, DD; True, RA | 1 |
| Cha, JH; Dure LS, IV; Penney, JB; Sakurai, SY; Young, AB | 1 |
| Cotman, CW; Koh, JY; Lin, A; Palmer, E | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Blazynski, C; Linn, DM; Massey, SC; Redburn, DA | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| Gallo, V; Levi, G; Patrizio, M | 2 |
| Mayer, ML; Patneau, DK | 1 |
| Dodd, PR; Johnston, GA; Maddison, JE; Watson, WE | 1 |
| Chiu, SY; Jensen, AM | 1 |
| Garcia-Ladona, FJ; Girard, C; Gombos, G; Palacios, JM | 1 |
| Sapru, H; Sundaram, K | 1 |
| Gannon, RL; Terrian, DM | 1 |
| MacVicar, BA; Tse, FW; Weiss, S | 1 |
| Chang, YC; Lee, YH; Leng, CH; Lin, YH | 1 |
| Eaton, SA; Roberts, WA; Salt, TE | 1 |
| Abe, M; Iino, M; Ozawa, S | 1 |
| Olney, JW; Pathikonda, M; Snider, WD; Stewart, GR | 1 |
| Coderre, TJ; Melzack, R | 1 |
| Aroniadou, VA; Teyler, TJ | 1 |
| Garthwaite, J; Southam, E | 1 |
| Cai, NS; Erdö, SL; Kiss, B | 1 |
| Cull-Candy, SG; Traynelis, SF | 1 |
| Hećimović, H; Randić, M; Ryu, PD | 1 |
| Mayer, ML | 1 |
| Ambrosini, A; Barnard, EA; Prestipino, G | 1 |
| Hartley, M; Heinemann, S; Hollmann, M | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Swartz, KJ | 1 |
| Amaya, Y; Hattori, S; Kawamoto, S; Mishina, M; Miyagi, Y; Okuda, K; Onishi, H | 1 |
| Franke, C; Hatt, H; Rosenheimer, JL; Smith, DO; Zufall, F | 1 |
| Berge, OG; Hole, K; Lund, A; Mjellem-Joly, N | 1 |
| Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A | 1 |
| Cherubini, E; Nistri, A | 1 |
| Uretsky, NJ; Wallace, LJ | 1 |
| Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C | 1 |
| Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD | 1 |
| Berg, M; Bruhn, T; Diemer, NH; Johansen, FF; Krogsgaard-Larsen, P | 1 |
| Leander, JD; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Ishii, T; Masu, M; Mizuno, N; Moriyoshi, K; Nakanishi, S; Shigemoto, R | 1 |
| Barnard, EA; Henley, JM | 1 |
| Baudry, M; Lynch, G; Massicotte, G; Vanderklish, P | 1 |
| Bowie, D; Smart, TG | 3 |
| Drejer, J; Honoré, T; Schousboe, A; Wahl, P | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J | 1 |
| Brehm, L; Jørgensen, FS; Krogsgaard-Larsen, P; Madsen, U; Schaumburg, K | 1 |
| Gallo, V; Giovannini, C; Levi, G | 1 |
| Cox, JA; Felder, CC; Henneberry, RC | 1 |
| Butterworth, RF; Cotman, CW; Giguere, JF; Peterson, C | 1 |
| Baimbridge, KG; Choi, DW; Koh, J; Weiss, JH | 1 |
| Ishida, M; Ishihara, T; Nakagawa, Y; Saitoh, K; Shinozaki, H | 1 |
| Dawson, TL; Dingledine, R; Nicholas, RA | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Meldrum, BS; Smith, SE | 1 |
| Bockaert, J; Charpentier, N; Dumuis, A; Pin, JP; Sebben, M | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J; Shand, A | 1 |
| Bian, XP; Martin, D; Morrisett, RA; Swartzwelder, HS; Wilson, WA | 1 |
| Ehrlich, D; Morgan, IG; Tung, NN | 1 |
| Anis, NA; Jones, MG; Lodge, D | 1 |
| Birch, PJ; Hayes, AG; Rogers, H | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Brooks, DN; Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J | 1 |
| Choi, DW; Hartley, DM; Koh, J; Weiss, JH | 1 |
| Herb, A; Keinänen, K; Sakmann, B; Seeburg, PH; Sommer, B; Verdoorn, TA; Werner, P; Wisden, W | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Balázs, R; Hack, N; Jørgensen, OS | 1 |
| Dechesne, CJ; Hunter, C; Wada, K; Wenthold, RJ | 1 |
| Baudry, M; Massicotte, G | 1 |
| Dragunow, M; Faull, RL; Jansen, KL | 2 |
| Beart, PM; Jarrott, B; Lewis, SJ; Louis, CJ; Louis, WJ; Verberne, AJ | 1 |
| Choi, DW; Goldberg, MP; Hartley, DM; Koh, JY | 1 |
| Yang, J; Zorumski, CF | 1 |
| Bockaert, J; Lory, P; Nargeot, J; Pin, JP; Rassendren, FA | 1 |
| Christensen, BN; O'Dell, TJ | 2 |
| Murase, K; Randic, M; Ryu, PD | 1 |
| Bridges, RJ; Cotman, CW; Kadri, M; Kahle, JS; Nunn, PB; Stevens, DR | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 2 |
| Ross, SM; Roy, DN; Spencer, PS | 1 |
| Greenamyre, JT; Young, AB | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 2 |
| Erdö, SL; Wolff, JR | 1 |
| Ito, I; Sugiyama, H; Taji, H; Watanabe, M; Yamamoto, Y | 1 |
| O'Dell, TJ | 1 |
| Westerberg, E; Wieloch, TW | 1 |
| Blake, JF; Brown, MW; Collingridge, GL; Yates, RG | 1 |
| Beart, PM; Cincotta, M; Summers, RJ | 1 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| Gulyás, J; Janáky, R; Kontro, P; Marnela, KM; Oja, SS; Varga, V | 1 |
| Ambrosini, A; Barnard, EA; Henley, JM; Krogsgaard-Larsen, P | 1 |
| Shreve, PE; Uretsky, NJ | 3 |
| Davies, LP; Dodd, PR; Dyer, JA; Johnston, GA; Nielsen, B; Watson, WE; Wong, LS | 1 |
| Kemp, JA; Priestley, T; Woodruff, GN | 1 |
| Cotman, CW; Monaghan, DT; Yao, D | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Cotman, CW; Monaghan, DT; Westerberg, E; Wieloch, T | 1 |
| Choi, DW; Koh, J; Peters, S | 1 |
| Morgan, IG | 1 |
| Benavides, J; Carter, C; Fage, D; Scatton, B | 1 |
| Cowburn, RF; Hardy, JA; Roberts, PJ | 1 |
| Henley, JM; Oswald, RE | 1 |
| Blake, JF; Brown, MW; Collingridge, GL | 1 |
| Davies, SN; Drejer, J; Fletcher, EJ; Honoré, T; Jacobsen, P; Lodge, D; Nielsen, FE | 1 |
| Dingledine, R; Verdoorn, TA | 1 |
| Miller, RJ; Murphy, SN | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Massey, SC; Miller, RF | 1 |
| Kerkut, GA; Mat Jais, AM; Walker, RJ | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 1 |
| Kawai, N; Masuzawa, T; Nakaima, T; Oguro, K; Tsubokawa, H | 1 |
| Baker, RC; Winter, CR | 1 |
| Ishida, M; Kataoka, K; Mitani, A; Nakamura, Y; Ogata, T; Shibata, T; Shinozaki, H; Tsuji, K | 1 |
| Barbeito, L; Estevez, AG; Stutzmann, JM | 1 |
| Brown, CS; Chen, Q; Harris, C; Howe, A; Reiner, A; Surmeier, DJ | 1 |
| Lovinger, DM | 1 |
| Lerma, J; Mellström, B; Naranjo, JR; Paternain, AV | 1 |
| Kuraishi, Y; Okano, K; Satoh, M | 2 |
| MacDermott, AB; Reichling, DB | 1 |
| Kaddis, FG; Uretsky, NJ; Wallace, LJ | 1 |
| Fedele, E; Raiteri, M; Versace, P | 1 |
| Miller, RF; Thoreson, WB | 1 |
| Anderton, BH; Leigh, PN; Meldrum, BS; Nunn, PB; Willis, CL | 2 |
| Glowinski, J; Prémont, J; Stella, N; Tencé, M | 1 |
| Späth, L; Starke, K; von Kügelgen, I | 1 |
| Lees, GJ; Leong, W | 4 |
| Cruickshank, AM; Henley, JM | 1 |
| Konnerth, A; Schneggenburger, R; Tempia, F | 1 |
| Gallo, V; Mayer, ML; Patneau, DK; Winters, C; Wright, PW | 1 |
| Donias, HW; Ha, LH; Spears, LC; Stanley, BG; Willett, VL | 1 |
| Klitgaard, H; Laudrup, P | 2 |
| Burnett, JP; May, PC; Mayne, NG; Sharp, RL; Snyder, YM | 1 |
| Johnston, MV; Supko, DE | 1 |
| Chiodo, LA; Freeman, AS; Zhang, J | 1 |
| Gyevai, A; Mike, A; Osipenko, O; Vizi, ES | 1 |
| Choi, DW; Turetsky, D; Weiss, JH; Wilke, G | 1 |
| Cull-Candy, SG; Wyllie, DJ | 1 |
| Consolandi, O; Fallacara, C; Memo, M; Pizzi, M; Spano, PF | 1 |
| Coenen, AM; Peeters, BW; Ramakers, GM; Vossen, JM | 1 |
| Coenen, AM; Ellenbroek, BA; Peeters, BW; Ramakers, GM; Vossen, JM | 1 |
| Folstein, SE; Hedreen, JC; Peyser, CE; Ross, CA; Wagster, MV | 1 |
| Lookingland, KJ; Moore, KE; Wagner, EJ | 1 |
| Boel, E; Suzdak, PD; Thomsen, C | 1 |
| Burnett, JP; Desai, MA; Schoepp, DD | 1 |
| Jane, DE; Mayer, ML; Watkins, JC; Wong, LA | 1 |
| Chang, YC; Wu, TY | 1 |
| Headley, PM; Herrero, JF; Parsons, CG | 1 |
| Engel, JA; Johannessen, K; Svensson, L; Zhang, J | 1 |
| Attwell, D; Kovalchuk, Y; Miller, B; Sarantis, M | 1 |
| Hardy, M; Pleasure, D; Pleasure, J; Shi, QY; Tang, CM; Williams, M; Younkin, D | 1 |
| Baude, A; McIlhinney, RA; Molnár, E; Nusser, Z; Somogyi, P | 1 |
| Keinänen, K; Köhr, G; Laukkanen, ML; Oker-Blom, C; Seeburg, PH | 1 |
| Brose, N; Egebjerg, J; Kukekov, V; Lin, F; Louis, JC; Moran, T; Puchalski, RB; Rogers, SW; Traynelis, SF; Wenthold, RJ | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Massieu, L; Tapia, R | 1 |
| Hatt, H; Kruse, M; Schmidt, KF | 1 |
| Azuma, Y; Han, D; Ogita, K; Sakamoto, T; Yoneda, Y | 1 |
| Amico, C; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Kaczmarek, L; Lukasiuk, K | 1 |
| Hall, RA; Kessler, M; Lynch, G | 1 |
| Akopian, A; Krizaj, D; Witkovsky, P | 1 |
| Wu, C | 1 |
| Endo, H; Ichimura, M; Mori, S; Okamoto, M | 1 |
| Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG | 1 |
| Adler-Graschinsky, E; Butta, NV; Lorenzo, PS | 1 |
| Bruno, VM; Choi, DW; Dugan, LL; Giffard, RG; Goldberg, MP | 1 |
| Aletras, AJ; Kouvelas, ED; Papaioannou, D; Sivvas, E; Voukelatou, G | 1 |
| Lancaster, J; Neale, JH; Sweetnam, PM; Valivullah, HM | 1 |
| Gruner, R; Parsons, CG; Rozental, J | 1 |
| Choi, DW; Weiss, JH; Yin, HZ | 1 |
| Ibarz, JM; Lerma, J; Morales, M; Somohano, F | 1 |
| Christakos, S; Devinsky, O; Howells, R; Lee, S; Lothman, E; Miskovsky, J; Williamson, J | 1 |
| Antonacci, R; Copeland, NG; Finelli, P; Gilbert, DJ; Jenkins, NA; Molné, M; Riviere, M; Rocchi, M; Szpirer, C; Szpirer, J | 1 |
| Bettler, B; Hartley, M; Heinemann, SF; O'Hara, PJ; Sheppard, PO; Stern-Bach, Y | 1 |
| Akinci, MK; Johnston, GA | 1 |
| Madamba, SG; Nie, Z; Siggins, GR | 1 |
| Albert, A; Bonhomme, V; Collette, J; Hans, P; Moonen, G | 1 |
| Andersen, PH; Hansen, A; Hansen, K; Jones, SV; Rasmussen, JS; Tygesen, CK | 1 |
| Gill, R | 1 |
| Burnett, JP; Desai, MA; Ornstein, PL; Schoepp, DD | 1 |
| Belluardo, N; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Jiang, X; Mudò, G | 1 |
| García, Y; Ibarra, C; Jaffé, EH | 1 |
| Greenwood, RS; Hayward, JN; McGinnis, S; Meeker, RB | 1 |
| Arvin, B; Meldrum, BS; Moncada, CR | 1 |
| Blanchard, JC; Doble, A; Petitet, F | 1 |
| Kouvelas, ED; Mitsacos, A; Zavitsanou, K | 1 |
| French, ED; Wang, T | 3 |
| Beckmann, H; Deckert, J; Hartmann, J; Heinsen, H; Krause, F; Künig, G; Niedermeyer, B; Ransmayr, G; Riederer, P | 1 |
| Oja, SS; Saransaari, P | 4 |
| Obrenovitch, TP; Urenjak, J; Zilkha, E | 1 |
| Carvalho, AP; Carvalho, CM; Duarte, CB; Ferreira, IL; Santos, PF | 1 |
| Cumberbatch, MJ; Headley, PM; Herrero, JF | 1 |
| Araki, N; Fukuuchi, Y; Komatsumoto, S; Ohta, K; Shibata, M; Shimazu, K | 1 |
| Jonas, P; Sakmann, B; Spruston, N | 1 |
| Fattman, CL; Hoyt, KR; Rajdev, S; Reynolds, IJ | 1 |
| Beal, MF; Cipolloni, PB; Ferrante, RJ; Henshaw, DR; Jenkins, BG; Kowall, NW; Rosen, BR; Schulz, JB; Siwek, D | 1 |
| Andersen, PH; Jørgensen, M; Tygesen, CK | 1 |
| Bloms-Funke, P; Madeja, M; Musshoff, U; Speckmann, EJ | 1 |
| Domenici, MR; Longo, R; Sagratella, S; Scotti de Carolis, A | 1 |
| Britto, LR; Duvoisin, RM; Hamassaki-Britto, DE; Zhang, C | 1 |
| Ambrósio, AF; Carvalho, AP; Carvalho, CM; Cunha, RA; Malva, JO; Ribeiro, JA | 1 |
| Rothwell, NJ; Strijbos, PJ | 1 |
| Dowling, JE; Grant, GB | 1 |
| Hatt, H; Jensen, P; Lowe, D; Smith, DO; Temkin, R | 1 |
| Grinspan, JB; Hardy, M; Pleasure, D; Stern, JL; Yoshioka, A; Younkin, DP | 1 |
| Kawai, N; Masuzawa, T; Oguro, K; Robinson, HP; Tsubokawa, H | 1 |
| Brorson, JR; Gibbons, SJ; Manzolillo, PA; Miller, RJ | 1 |
| Cordi, AA; Desos, P; Lepagnol, J; Randle, JC | 1 |
| Balcar, VJ; Killinger, S; Li, Y | 1 |
| Hu, B; Nissen, R; Renaud, LP | 1 |
| Desai, MA; Monn, JA; Schoepp, DD; Valli, MJ | 1 |
| Audinat, E; Crépel, F; Renard, A | 1 |
| Horimoto, N; Kawamoto, I; Nabekura, J; Ogawa, T | 1 |
| Balázs, R; Hack, N | 1 |
| Drejer, J; Johansen, TH; Nielsen, EO; Wätjen, F | 1 |
| Drian, MJ; König, N; Serrano, P | 1 |
| Bischoff, F; Ebert, B; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U | 1 |
| McCarthy, KD; Porter, JT | 1 |
| Lu, YM; Weiss, JH; Yin, HZ | 1 |
| Budai, D; Larson, AA; Wilcox, GL | 1 |
| Goldstein, PA; Heath, MJ; Kyrozis, A; MacDermott, AB | 1 |
| Geiger, JR; Jonas, P; Koh, DS; Sakmann, B | 1 |
| Henley, JM | 1 |
| Bigge, CF; Borosky, SA; Boxer, PA; Lescosky, LJ; Malone, TC; Nelson, CB; Ortwine, DF; Retz, DM; Schelkun, RM; Vartanian, MG | 1 |
| Donevan, SD; Rogawski, MA | 2 |
| Ault, B; Krafte, DS; Oleynek, JJ; Sawutz, DG | 1 |
| Kwak, S; Nakamura, R | 2 |
| Catania, MV; Hollingsworth, Z; Penney, JB; Young, AB | 1 |
| Choi, DW; Hartley, DM; Koh, JY; Weiss, JH | 1 |
| Henley, JM; Hunt, SP; Jenkins, R | 1 |
| Lodge, D; Palmer, AJ | 1 |
| Boldry, RC; Chase, TN; Engber, TM; Kelland, MD | 1 |
| Craig, CG; White, TD | 1 |
| May, PC; Robison, PM | 1 |
| Baron, SP; Woods, JH | 1 |
| Andou, Y; Enomoto, R; Kataoka, K; Mitani, A; Ogita, K; Yoneda, Y | 1 |
| Birse, EF; Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Sunter, DC; Udvarhelyi, PM; Wharton, B | 1 |
| Herrling, PL; Meier, CL | 1 |
| Lemaire, S; Shukla, VK | 1 |
| Sorimachi, M | 1 |
| Chen, LL; Harris, RA; Lin, LH | 1 |
| Bahr, BA; Baudry, M; Hall, RA; Lynch, G; Suppiramaniam, V; Vodyanoy, V | 1 |
| Matute, C; Miledi, R | 1 |
| Cid, ME; Ortega, A | 1 |
| Brackley, PT; Usherwood, PN | 1 |
| Bessho, Y; Nakanishi, S; Nawa, H | 1 |
| Bowlby, MR | 1 |
| Ferrer-Montiel, AV; Montal, M; Planells-Cases, R; Sun, W | 1 |
| Cai, N; Erdö, SL; Lakics, V | 1 |
| Bridges, RJ; Miller, S; Nunn, PB | 1 |
| Ambrosini, A; Racagni, G | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Edwards, AM; Heinemann, SF; Huntley, GW; Moran, T; Morrison, JH; Rogers, SW; Vickers, JC | 1 |
| Honoré, T; Sheardown, MJ; Suzdak, PD | 1 |
| Mayer, ML; Patneau, DK; Vyklicky, L | 1 |
| Abutidze, K; Barnard, EA; Kerry, CJ; Mellor, IR; Sudan, HL; Usherwood, PN | 1 |
| Fukuda, H; Hicks, TP; Kobayashi, T; Nagao, T; Oka, JI | 1 |
| Dee, MG; Ha, LH; Spears, LC; Stanley, BG | 1 |
| Rigor, BM; Schurr, A | 1 |
| Hensley, SH; Wu, SM; Yang, XL | 1 |
| Albin, RL; Kremer, B; Tallaksen-Greene, SJ | 1 |
| Naarala, J; Nykvist, P; Savolainen, K; Tuomala, M | 1 |
| Gordon, FJ; Kiely, JM | 1 |
| Yoneda, Y | 1 |
| Mayer, ML; Wong, LA | 1 |
| Henry, JL; Radhakrishnan, V | 1 |
| Iino, M; Ozawa, S | 1 |
| Lehmann, JC; Procureur, D; Wood, PL | 1 |
| Netzer, R; Pflimlin, P; Trube, G | 1 |
| Hammerland, LG; Parks, TN; Zhou, N | 1 |
| Klockgether, T; Turski, L | 1 |
| Gorodinsky, A; Paas, Y; Teichberg, VI | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Barnes, S; Mahmud, F; Merchant, V | 1 |
| De Bernardi, R; Ferro, F; Fontana, G; Gemignani, A; Raiteri, M | 1 |
| Gallo, V; Holtzclaw, LA; Russell, JT | 1 |
| Böing, C; Fink, K; Göthert, M; Schmitz, V | 1 |
| Kawasaki, I; Wakakura, M | 1 |
| Benz, AM; Izumi, Y; Kurby, CO; Labruyere, J; Olney, JW; Price, MT; Zorumski, CF | 1 |
| Pidoplichko, VI; Reymann, KG; Wilsch, VW | 1 |
| Garaschuk, O; Kano, M; Konnerth, A; Plant, T; Schirra, C; Schneggenburger, R; Tempia, F | 1 |
| Kumamoto, E; Murata, Y | 1 |
| Martin, D; Swartzwelder, HS; Tayyeb, MI | 1 |
| Cordi, AA; Desos, P; Lepagnol, JM; Lestage, P; Morain, P | 1 |
| Altemus, KL; Cepeda, C; Colwell, CS; Levine, MS | 1 |
| Church, J; McLarnon, JG; Sawyer, DC | 1 |
| Giovannucci, DR; Stuenkel, EL | 1 |
| Elliott, CE; Fletcher, EJ; Hoo, KH; Kamboj, RK; Korczak, B; McWhinnie, EA; Nutt, SL | 1 |
| Friedemann, MN; Gerhardt, GA | 1 |
| Cebers, G; Kalda, A; Liljequist, S | 1 |
| Jedema, HP; Moghddam, B | 1 |
| Gilbert, E; Grimwood, S; Hutson, PH; Ragan, CI | 1 |
| Brann, DW; Mahesh, VB; Zamorano, PL; Zuo, Z | 1 |
| Bristow, DR; Platt, KP | 1 |
| Auth, F; DeBoer, P; Moor, E; Westerink, BH | 1 |
| Allen, NK; Arnold, MB; Bleisch, T; Borromeo, PS; Leander, JD; Lodge, D; Lugar, CW; Ornstein, PL; Schoepp, DD | 2 |
| Chiba, C; Saito, T | 2 |
| Buisson, A; Choi, DW; Yu, SP | 1 |
| Bonasera, L; Carlton, SM; Zhou, S | 1 |
| Aneiros, A; Flores, A; Garateix, A; García-Andrade, JM; Palmero, A; Soto, E; Vega, R | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Carvalho, AP; Duarte, CB; Sánchez-Prieto, J; Santos, PF | 1 |
| Araujo, M; Wandosell, F | 1 |
| Parks, TN; Taylor, DA; Zhou, N | 1 |
| Binding, N; Madeja, M; Musshoff, U; Speckmann, EJ; Witting, U | 1 |
| Carriedo, SG; Weiss, JH; Yin, HZ | 1 |
| Chiang, J; Lu, YM; Weiss, JH; Yin, HZ | 1 |
| Carvalho, AP; Duarte, CB; Santos, PF | 2 |
| Dee, MG; Donias, HW; Duva, MA; Stanley, BG; Willett, VL | 1 |
| Miller, RJ; Prehn, JH | 1 |
| Ossowska, K | 1 |
| Davey, PG; Halliwell, RF; Lambert, JJ | 1 |
| White, TD | 1 |
| Iino, M; Isa, T; Itazawa, S; Ozawa, S; Tsuzuki, K | 1 |
| Barrios, M; Liljequist, S | 1 |
| Carvalho, AP; Carvalho, CM; Malva, JO | 1 |
| Giffard, RG; Panter, SS; Regan, RF; Tilly, JL; Witz, A | 1 |
| Hartveit, E | 1 |
| Banke, T; Krogsgaard-Larsen, P; Madsen, U; Schousboe, A; Wahl, P | 1 |
| Regan, RF | 1 |
| Feltz, P; Jo, YH; Poisbeau, P; Schlichter, R | 1 |
| Panter, SS; Regan, RF | 1 |
| Dougherty, PM; Lenz, FA; Li, YJ; Mittman, S; Rowland, L | 1 |
| Chang, YC; Gao, LH; Li, BF; Liu, CI; Wu, CL; Wu, TY | 1 |
| Kohara, A; Okada, M; Yamaguchi, T | 1 |
| Ishikawa, S; Kawasaki, I; Wakakura, M | 1 |
| Bizon, JL; Gallagher, M; Nicolle, MM | 1 |
| Abiko, Y; Hara, A; Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tanno, K | 1 |
| Fiskum, G; Perry, DC; Rosenthal, RE; Wei, H | 1 |
| Miller, DD; Shams, G; Sun, G; Uretsky, NJ; Wallace, LJ; Weinstein, DM | 1 |
| Albrecht, J; Borkowska, HD; Oja, SS; Saransaari, P | 2 |
| Ben-Yoseph, O; Boxer, PA; Ross, BD | 1 |
| Gruol, DL; Netzeband, JG; Parsons, KL | 1 |
| Bulloch, AG; Lukowiak, K; Magoski, NS; McKenney, KK; Nesic, OB; Syed, NI | 1 |
| Chisamore, B; Dow, K; Solc, M | 1 |
| Bacskai, B; Pleasure, D; Yoshioka, A | 1 |
| Bouazzaoui, M; Gombos, G; Kannengieser, C; Procksch, O | 1 |
| Corradetti, R; Passani, MB; Pepeu, G; Pugliese, AM | 1 |
| Baudry, M; DeSimoni, MG; Finch, CE; Mascarucci, P; Musleh, WD; Pasinetti, GM; Sakhi, S; Schreiber, S; Tocco, G | 1 |
| Martin, G; Nie, Z; Siggins, GR | 1 |
| Agrawal, SK; Fehlings, MG | 1 |
| Christensen, J; de la Riva, C; Emson, PC; Guevara-Guzman, R; Kendrick, KM; Ostergaard, K | 1 |
| de Erausquin, G; Hanbauer, I; Isaacs, KR; Jacobowitz, DM; Strauss, KI | 1 |
| Fuson, KS; May, PC; Ornstein, PL; Sacaan, AI; Salhoff, CR; Schoepp, DD; Tizzano, JP | 1 |
| Easaw, JC; Jhamandas, JH; Petrov, T | 1 |
| Grino, M; Joanny, P; Oliver, C; Steinberg, J | 2 |
| Alici, K; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Asztely, F; Erdemli, G; Kullmann, DM | 1 |
| Chakravarthy, B; Durkin, JP; Mealing, G; Morley, P; Small, D; Song, D; Tremblay, R | 1 |
| Matute, C; Sanchez-Gomez, MV | 1 |
| Deitmer, JW; Munsch, T | 1 |
| Baron, JC; Dauphin, F; Kawasaki, T; Kiyosawa, M; MacKenzie, ET; Rioux, P; Tokoro, T | 1 |
| Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F | 1 |
| Fergus, A; Lee, KS | 1 |
| Inoue, T; Ito, KI; Kato, H; Mikoshiba, K; Miyakawa, H | 1 |
| Choi, DW; Dugan, LL; Gabrielsen, JK; Lin, TS; Yu, SP | 1 |
| Häusser, M; Roth, A | 1 |
| Aramakis, VB; Ashe, JH; Bandrowski, AE | 1 |
| Janáky, R; Jenei, Z; Oja, SS; Saransaari, P; Varga, V | 1 |
| Frandsen, A; Griffiths, R; Malcolm, C; Meredith, C; Ritchie, L; Rumsby, P; Schousboe, A; Scott, M | 1 |
| Talman, WT | 1 |
| Bonfanti, A; Pittaluga, A; Raiteri, M | 1 |
| Maeda, H; Minami, T; Ogita, K; Shuto, M; Yoneda, Y | 1 |
| Mifflin, SW; Zhang, J | 2 |
| Butterfield, BS; Grewal, RS; Stanley, BG | 1 |
| Ayata, C; Ayata, G; Beal, MF; Christie, RH; Endres, M; Ferrante, RJ; Hara, H; Huang, PL; Hyman, BT; Kim, A; Matthews, RT; Moskowitz, MA; Waeber, C | 1 |
| Hajimohammadreza, I; Nadimpalli, R; Nath, R; Raser, KJ; Scott, M; Wang, KK | 1 |
| Bang-Andersen, B; Bøgesø, KP; Ebert, B; Hansen, HO; Krogsgaard-Larsen, P; Lenz, SM; Skjaerbaek, N; Søby, KK | 1 |
| Fontana, G; Gemignani, A; Marchese, S; Raiteri, M | 1 |
| Blue, ME; Brennan, EM; Johnston, MV; Martin, LJ | 1 |
| Ebert, B; Frølund, B; Jaroszewski, JW; Krogsgaard-Larsen, P; Matzen, L; Stensbøl, TB | 1 |
| Bleakman, D; Bristow, DR; Savidge, JR | 1 |
| Ebert, B; Frydenvang, K; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U | 1 |
| Isa, T; Itazawa, SI; Ozawa, S | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Huang, JC; Ilyin, VI; Keana, JF; Tran, M; Weber, E; Woodward, RM | 1 |
| Kohara, A; Ohno, K; Okada, M; Tsutsumi, R; Yamaguchi, T | 1 |
| Canzoniero, LM; Choi, DW; Grabb, M; Monyer, H; Sensi, SL; Sheline, CT; Weishaupt, JH; Ying, HS | 1 |
| Canzoniero, LM; Choi, DW; Kerchner, GA; Koh, JY; Sensi, SL; Ying, HS; Yu, SP | 1 |
| Akaike, N; Rhee, JS | 1 |
| DiJulio, N; Gruol, DL; Parsons, KL | 1 |
| Almazan, G; Liu, HN; Molina-Holgado, E | 1 |
| Kleinrok, Z; Kocki, T; Saran, T; Turski, WA; Urbanska, EM | 1 |
| Feroah, T; Forster, HV; Forster, MM; Gershan, WM; Lowry, TF; Pan, LG; Sprtel, B; Whaley, AA | 1 |
| Clayton, P; Jane, DE; Thomas, NK | 1 |
| Ambrósio, AF; Carvalho, AP; Carvalho, CM; Malva, JO | 1 |
| Baltrons, MA; García, A | 1 |
| Herbert, J; Khatibi, NH; Kimonides, VG; Sofroniew, MV; Svendsen, CN | 1 |
| Althomsons, SP; Choi, DW; Goldberg, MP; Hyrc, KL; McDonald, JW | 1 |
| Carriedo, SG; Ha, DH; Weiss, JH; Yin, HZ | 1 |
| Ohno, K; Okada, M; Sakamoto, S; Tsutsumi, R; Yamaguchi, T | 1 |
| Kabakov, AY; Karkanias, NB; Lenox, RH; Papke, RL | 1 |
| Durkin, JP; Mealing, GA; Morley, P; Murray, CL; Poulter, MO; Small, DL; Stanimirovic, DB | 1 |
| Furukawa, K; Mattson, MP | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Marfia, GA; Pisani, A; Sancesario, G | 1 |
| Matsumoto, N; Ohno, K; Okada, M; Tsutsumi, R; Yamaguchi, T | 1 |
| Bureau, I; Mulle, C | 1 |
| Dougherty, PM; Lenz, FA; Mittman, S | 1 |
| Bardoul, M; König, N; Levallois, C | 1 |
| González, MP; Herrero, MT; Oset-Gasque, MJ; Vicente, S | 1 |
| Horiuchi, K; Itoh, A; Itoh, T; Pleasure, D | 1 |
| Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G | 1 |
| Lerma, J; Rodríguez-Moreno, A | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T; Yanase, T | 1 |
| López, T; López-Colomé, AM; Ortega, A | 1 |
| Chen, Q; Flores-Hernandez, J; Jiao, Y; Reiner, A; Stefani, A; Surmeier, DJ | 1 |
| Beart, PM; Carroll, FY; Cheung, NS | 1 |
| Bhattacharyya, T; Canzoniero, LM; Choi, DW; Lobner, D; McDonald, JW; Sensi, SL; Ying, HS | 1 |
| Lu, T; Shen, Y; Yang, XL | 1 |
| Sattler, R; Spetzler, RF; Tymianski, M; Zabramski, JM | 1 |
| Trombley, PQ | 1 |
| Bowie, D; Lange, GD; Mayer, ML | 1 |
| Capito, B; Martens, U; Wree, A | 1 |
| Kato, BM; Lachica, EA; Lippe, WR; Rubel, EW | 1 |
| Holmberg, L; Souverbie, F; Sundström, E | 1 |
| Banno, T; Kohno, K | 1 |
| Carvalho, AP; Duarte, CB; Ferreira, IL | 1 |
| Dai, WM; Ebert, B; Lambert, JD; Madsen, U | 1 |
| Solomon, IC | 1 |
| Best, JD; Hastings, MH; McNulty, S; Schurov, IL; Sloper, PJ | 1 |
| Fryer, HJ; Kalb, RG; Knox, RJ; Strittmatter, SM | 1 |
| Gwag, BJ; Joe, E; Kim, EY; Kim, YH; Koh, JY; Sohn, S | 1 |
| D'Hooge, R; De Deyn, PP; Raes, A; Van Bogaert, PP; Van de Vijver, G | 1 |
| Akaike, N; Harata, N; Katayama, J | 1 |
| Hargreaves, KM; Jackson, DL | 1 |
| Marshall, KC; Pelkey, KA | 1 |
| Alberch, J; Arenas, E; Canals, JM; Checa, N; Marco, S; Michels, A; Pérez-Navarro, E | 1 |
| Sako, N; Yamamoto, T | 1 |
| Almazan, G; Larocca, JN; Liu, HN | 1 |
| Blanco, R; de la Villa, P | 1 |
| Smith, AL; Thompson, ID | 1 |
| Geurtz, W; Hatt, H; Okada, T; Schultz, K; Weiler, R | 1 |
| Molnár, P; Nadler, JV; Okazaki, MM | 1 |
| Alvarez, RM; Cárdenas, AM; Caviedes, P; Caviedes, R; Cortés, MP; Rapoport, SI; Rodríguez, MP; Shimahara, T; Wei, W | 1 |
| Goshima, Y; Kawashima, K; Misu, Y; Miyamae, T; Ohshima, E; Shibata, T; Shimizu, M; Suzuki, F | 1 |
| Marc, RE | 2 |
| Aleu, J; Barat, A; Burgos, JS; Marsal, J; Ramírez, G; Solsona, C | 1 |
| Fuson, KS; May, PC; Robison, PM | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Perkinton, MS; Sihra, TS | 1 |
| Cannon, RC; Chad, JE; Chen, Y; Wheal, HV | 1 |
| Cho, K; Little, HJ | 1 |
| Bidmon, HJ; Mayer, B; Oermann, E; Palomero-Gallagher, N; Schleicher, A; Wu, J; Zilles, K | 1 |
| Araneda, RC; Dobrenis, K; Fan, D; Grooms, SY; Johnson, AB; Kessler, JA; Zukin, RS | 1 |
| Aguilar, E; González, LC; Pinilla, L; Tena-Sempere, M | 2 |
| Johns, RA; Tichotsky, A; Zuo, Z | 1 |
| Al-Ghoul, W; Curras, MC; Meeker, RB; Serje, A; Stewart, J | 1 |
| Chen, Q; Reiner, A; Surmeier, DJ | 1 |
| Bleakman, D; Hoo, K; Ogden, AM; Ornstein, PL | 1 |
| Que, M; Schiene, K; Witte, OW; Zilles, K | 1 |
| Arcaya, JL; Cano, G; Cuesta, MC; Maixner, W; Sanchez, L; Suarez-Roca, H | 1 |
| Hanania, T; Johnson, KM | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M | 1 |
| Ebert, B; Gramsbergen, JB; Jakobsen, B; Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Chouvet, G; Dugast, C; Schmitt, P; Souliere, F | 1 |
| Kuna, ST; Remmers, JE | 1 |
| De Smedt, H; Missiaen, L; Robberecht, W; Van Den Bosch, L; Verhoeven, K; Wuytack, F | 1 |
| Anderson, KJ; Burchfield, DJ; Mason, KL; McGraw, TS; Sapper, MS; Theophilopoulos, DT | 1 |
| Bardgett, ME; Henry, JD | 1 |
| Köhling, R; Qü, MS; Speckmann, EJ; Zilles, K | 1 |
| Brorson, JR; Robberecht, W; Vandenberghe, W | 1 |
| Herrera, MT; Lerma, J; Nieto, MA; Paternain, AV | 1 |
| Carriedo, SG; Sensi, SL; Weiss, JH; Yin, HZ | 1 |
| Akaike, N; Nabekura, J; Nakanishi, H; Noda, M | 1 |
| Cooke, IM; Duan, S | 1 |
| Ballanyi, K; Kulik, A; Metzger, F; Sendtner, M | 1 |
| Lerma, J; López-García, JC; Rodríguez-Moreno, A | 1 |
| June, CH; Marini, AM; Ueda, Y | 1 |
| Gwag, BJ; Jou, I; Kim, EY; Kim, H; Seo, SY | 1 |
| Cruise, L; Fuller, G; Ho, LK; Morris, BJ; Veitch, K | 2 |
| Chen, S; Lin, X | 1 |
| Andrianov, GN; Ryzhova, IV | 1 |
| Trussell, LO; Turecek, R | 1 |
| Fincher, A; Frye, GD | 1 |
| Abraini, JH; Kriem, B; Rostain, JC | 1 |
| Beal, MF; Kaddurah-Daouk, R; Malcon, C | 1 |
| Connaughton, VP; Nelson, R | 1 |
| Kapustecki, J; Pierzchała, K | 1 |
| Akaike, A; Honda, Y; Kashii, S; Sasa, M; Tamura, Y; Ujihara, H; Yasuyoshi, H; Zhang, S | 1 |
| Cebers, G; Kovács, AD; Liljequist, S | 1 |
| Choi, MR; Chung, KM; Huh, SO; Kim, YH; Lee, KC; Song, DK; Suh, HW | 1 |
| Durkin, JP; Gendron, TF; MacLean, S; Mealing, G; Morley, P; Small, DL; Tremblay, R | 1 |
| Ambrósio, AF; Carvalho, AP; Carvalho, CM; Malva, JO; Mesquita, JF; Silva, AP | 1 |
| Crusio, WE; Schwegler, H; Wu, J; Zilles, K | 1 |
| Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M | 1 |
| Okada, D | 1 |
| Andreadis, JD; Barker, JL; Chang, YH; Grant, GM; Hu, Q; Joseph, J; Liu, QY; Ma, W; Maric, D; Stenger, DA | 1 |
| Abrahám, G; Andrási, F; Berzsenyi, P; Csuzdi, E; Hámori, T; Hársing, LG; Horváth, G; Horváth, K; Kapus, G; Király, I; Ling, I; Pallagi, I; Patthy, M; Sólyom, S; Tarnawa, I | 1 |
| Bohme, GA; Boireau, A; Chevé, M; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bolshakov, KV; Buldakova, SL; Magazanik, LG; Tikhonov, DB | 1 |
| Brorson, JR; Ihle, EC; Patneau, DK; Robberecht, W; Vandenberghe, W | 1 |
| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Senaldi, A; Somaini, L; Zanetti, E | 1 |
| Custodio, D; Hallak, M; Hotra, JW; Kruger, ML | 1 |
| Caicedo, A; Jafri, MS; Roper, SD | 1 |
| Haga, M; Kinoshita, M; Moriyama, Y; Otsuka, M; Takeda, M; Tsuboi, S; Yamada, H | 1 |
| Chatton, JY; Magistretti, PJ; Marquet, P | 1 |
| Armstrong, N; Gouaux, E | 1 |
| Cebere, A; Cebers, G; Kovács, AD; Liljequist, S; Moreira, T | 1 |
| Morsette, DJ; Sidorowicz, H; Sladek, CD | 1 |
| Akaike, A; Honda, K; Inoue, R; Kihara, T; Nakamizo, T; Sawada, H; Shimohama, S; Urushitani, M | 1 |
| Inoue, N; Nakayama, T; Soga, TM | 1 |
| Carvalho, AP; Carvalho, CM; Malva, JO; Sequeira, SM | 1 |
| Meador-Woodruff, JH; Ritter, LM; Unis, AS | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Kubrusly, RC; Loureiro-Dos-Santos, NE; Reis, RA | 1 |
| Avanzini, G; Ientile, R; Macaione, V; Oteri, G; Pedale, S; Pisani, F; Torre, V | 1 |
| Martens, U; Wree, A | 1 |
| Canonico, PL; Dianzani, C; Fantozzi, R; Lombardi, G; Miglio, G | 1 |
| Hu, GY; Zhang, JM | 1 |
| Nikbakht, MR; Stone, TW | 1 |
| Krogsgaard-Larsen, P; Madsen, U; Stensbøl, TB | 1 |
| Horie, S; Tsuchiya, S; Watanabe, K; Yano, S | 1 |
| Ientile, R; Macaione, S; Macaione, V; Pedale, S; Teletta, M; Torre, V | 1 |
| Kristensen, BW; Noraberg, J; Zimmer, J | 2 |
| Capobianco, A; Comoletti, D; Mennini, T; Muzio, V; Ravizza, T | 1 |
| Jakobsen, B; Zimmer, J | 1 |
| Homma, M; Wang, X; Wang, XQ; Xiao, AY; Yu, SP | 1 |
| Baba, M; Ikegaya, Y; Iwatsubo, T; Kim, JA; Matsuki, N; Nishiyama, N | 1 |
| Bianchi, L; Colivicchi, MA; Della Corte, L; Frosini, M; Palmi, M | 1 |
| Dikranian, K; Farber, NB; Heinkel, C; Jiang, XP; Kim, SH | 1 |
| Christensen, KV; Dai, WM; Ebert, B; Egebjerg, J; Lambert, JD | 1 |
| Attwell, D; Hamann, M; Marie, H; Rossi, DJ | 1 |
| Alberdi, E; Marino, A; Matute, C; Sánchez-Gómez, MV | 1 |
| Lee, SY; Oh, S; Ryoo, IJ; Shin, MH; Yoo, ID; Yun, B | 1 |
| Carvalho, CM; Cristóvão, AJ; Oliveira, CR | 1 |
| Chiang, AS; Lin, SC; Liu, HP; Pszczolkowski, MA | 1 |
| Hartveit, E; Mørkve, SH; Veruki, ML | 1 |
| Mao, L; Wang, JQ | 1 |
| Carpenter, DO; Hori, N; Strominger, NL; Tan, Y | 1 |
| Lisý, V; Stastný, F | 1 |
| Fujimori, S; Hinoi, E; Takarada, T; Taniura, H; Yoneda, Y | 1 |
| Duncan, G; Gu, H; Koller, B; Lieberman, J; Miyamoto, S; Snouwaert, J | 1 |
| Chan, JY; Lo, WC; Tseng, CJ; Tung, CS | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Ramadan, NM | 1 |
| Brown, JJ; Bushman, SM; Pszczolkowski, MA; Zahand, A | 1 |
| Ali, S; Back, SA; Dai, W; Follett, PL; Fu, J; Gan, XD; Jensen, FE; Rosenberg, PA; Sanchez, RM; Segal, MM; Volpe, JJ | 1 |
| Colonnese, MT; Constantine-Paton, M; Shi, J | 1 |
| Andersen, KA; Kreitzer, MA; Malchow, RP | 1 |
| Bräuner-Osborne, H; Bunch, L; Frydenvang, K; Greenwood, JR; Krogsgaard-Larsen, P; Liljefors, T; Madsen, U | 1 |
| Kakuda, T; Niino, H; Nozawa, A; Sugimoto, A | 1 |
| Chen, WY; Kuo, JS; Tsai, PJ; Yang, CS | 1 |
| Clippe, A; Gressens, P; Knoops, B; Plaisant, F; Vander Stricht, D | 1 |
| Bevilaqua, LR; Bonini, JS; Cammarota, M; Izquierdo, I; Kerr, DS; Rodrigues, L | 1 |
| Amada, Y; Matsumoto, N; Ohno, K; Okada, M; Sakamoto, S; Shishikura, J; Tsutsumi, R; Yamaguchi, T; Yamashita, H; Yatsugi, HI | 1 |
| Ben-Zakay, N; Besser, M; Ganor, Y; Levite, M; Unger, T | 1 |
| Carvalho, AP; Carvalho, CM; Jakobsen, B; Malva, JO; Pinheiro, PS; Silva, AP; Zimmer, J | 1 |
| Frye, GD; Hsiao, SH | 1 |
| Gouaux, E; Jin, R | 1 |
| Korpi, ER; Lovinger, DM; Möykkynen, T | 1 |
| Lasater, EM; Vigh, J | 1 |
| Díaz-Trelles, R; Fernández-Sánchez, MT; Novelli, A | 1 |
| Le Roux, PD; Monnerie, H; Shashidhara, S | 1 |
| Akaike, A; Honda, Y; Kashii, S; Ujihara, H; Yamauchi, T; Yasuyoshi, H; Zhang, S | 1 |
| Bianchi, L; Bolam, JP; Della Corte, L; Galeffi, F | 1 |
| Hollmann, M; Madsen, DM; Maricq, AV; Seebohm, G; Strutz-Seebohm, N; Walker, CS; Werner, M; Zheng, Y | 1 |
| Bräuner-Osborne, H; Christensen, JK; Fischer, CH; Kristensen, AS; Krogsgaard-Larsen, P; Madsen, U; Nielsen, B; Nielsen, EØ; Pickering, DS; Valgeirsson, J | 1 |
| Kass-Simon, G; Pannaccione, A; Pierobon, P | 1 |
| Choi, L; Girgis, R; Gottlieb, DI; Lee, CS; Lewis, B; Liu, S; Lu, A; McDonald, JW; Qu, Y; Snider, BJ; Vadivelu, S | 1 |
| Johnson, MS; Keinänen, K; Pentikäinen, OT; Settimo, L | 1 |
| Cosi, C; Guerin, K; Koek, W; Marien, M; Rollet, K | 1 |
| Maar, TE; Poulsen, CF; Schousboe, A; Simeone, TA; Smith-Swintosky, V; White, HS | 1 |
| De Mello, FG; Ferreira, ST; Louzada, PR; Mendonca-Silva, DL; Noël, F; Paula Lima, AC | 1 |
| Jones, TL; Sorkin, LS | 1 |
| Bruno, V; Caciagli, F; Caricasole, A; Caruso, A; Castiglione, M; Di Giorgi Gerevini, V; Marinelli, F; Melchiorri, D; Moretti, A; Nicoletti, F; Pozzilli, C; Tomassini, V | 1 |
| Bae, CD; Jeon, S; Kim, EG; Kim, SJ; Park, J; Shin, EY | 1 |
| Cheng, Q; Jayaraman, V | 1 |
| Alonso, TJ; Castro Fuentes, R; García Dopico, J; González Hernández, T; Perdomo Díaz, J; Rodríguez Díaz, M | 1 |
| Corona, JC; Tapia, R | 1 |
| Friauf, E; Löhrke, S; Reusch, M; Vitten, H | 1 |
| Hamanaka, N; Ito, S; Matsumura, S; Minami, T; Nishizawa, M; Sasaguri, Y | 1 |
| Alt, AJ; Bleakman, D; Bortolotto, ZA; Buelens, FP; Clarke, VR; Collingridge, GL; Dolman, NP; Jane, DE; Kelland, EE; More, JC; Nistico, R; Ogden, AM; Pilato, F; Troop, HM | 1 |
| André, N; Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B | 1 |
| Frank, E | 1 |
| Finnegan, S; Higgins, D; Lein, P; Shen, W; Slaughter, M; Sullivan, S | 1 |
| Almazan, G; Antel, JP; Nalbantoglu, J; Olivier, A; Ruffini, F; Wosik, K | 1 |
| Bringmann, A; Klaus, C; Reichenbach, A; Rillich, K; Syková, E; Uckermann, O; Ulbricht, E; Vargová, L; Weick, M; Wiedemann, P | 1 |
| Balthazart, J; Cornil, CA; Motte, P; Seutin, V | 1 |
| Cheng, Q; Jayaraman, V; Keinänen, K; Madden, DR; Rajan, S; Reinelt, S; Rigo, F; Thiran, S; Zimmermann, H | 1 |
| Beyer, C; Bulling, A; Dinse, A; Föhr, KJ; Georgieff, M; Weigt, HU | 1 |
| Bennett, SA; Cheung, EC; Cregan, SP; Ferguson, KL; McIntosh, WC; Melanson-Drapeau, L; Park, DS; Slack, RS; Vanderluit, JL | 1 |
| Bai, D; Frandsen, A; Gong, XQ; Lu, WY; Pickering, DS; Wan, Y; Zabek, RL | 1 |
| O'neill, MF; Ornstein, PL; Osborne, DJ; Sanger, G; Woodhouse, SM | 1 |
| Beneyto, M; Dean, B; Meador-Woodruff, JH; Scarr, E | 1 |
| Bannister, NJ; Benke, TA; Crabtree, JW; Gürdal, E; Isaac, JT; Mellor, J; Scott, H | 1 |
| Chergui, K; Greengard, P; Svenningsson, P | 1 |
| Huang, XF; Newell, KA; Zavitsanou, K | 1 |
| Haas, HS; Heintz, E; Ingolic, E; Pfragner, R; Schauenstein, K; Siegl, V | 1 |
| Coons, S; Ellsworth, K; Johnson, E; Kerrigan, JF; Kim, DY; Lue, LF; Nowak, L; Rekate, H; Rho, JM; St John, PA; Wu, J; Xu, L | 1 |
| Kartelija, G; Radenović, L; Selaković, V | 1 |
| Baillien, M; Ball, GF; Balthazart, J | 1 |
| Galik, J; Gerber, G; Park, YK; Randić, M; Voitenko, N; Youn, DH | 1 |
| Adesnik, H; Bredt, DS; Byrd, K; Elias, GM; Karimzadegan, S; Kealey, C; Nicoll, RA; Petralia, RS; Rouach, N; Tomita, S | 1 |
| Bambrick, LL; Hilton, GD; McCarthy, MM; Thompson, SM | 1 |
| Kalloniatis, M; Sun, D | 1 |
| Akasofu, S; Kimura, M; Kosasa, T; Ogura, H; Sawada, K | 1 |
| Anderson, RL; Daniele, C; Engelman, HS; Macdermott, AB | 1 |
| Gudz, TI; Komuro, H; Macklin, WB | 1 |
| Georgescu, M; Pfaus, JG | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Joshi, NB; Joshi, PG; Sanganahalli, BG | 1 |
| Bibbig, A; Cunningham, MO; LeBeau, FE; Middleton, SJ; Roopun, AK; Traub, RD; Whittington, MA | 1 |
| Du, M; Jayaraman, V; Mankiewicz, KA; Ramanoudjame, G; Rambhadran, A | 1 |
| Lalo, U; North, RA; Pankratov, Y; Verkhratsky, A | 1 |
| Dohovics, R; Janáky, R; Oja, SS; Saransaari, P | 1 |
| Billard, JM; Rouaud, E | 1 |
| Erdélyi, F; Fiszman, ML; Szabó, G; Vicini, S | 1 |
| Andrianov, GN; Nozdrachev, AD; Ryzhova, IV | 1 |
| Aono, S; Hayakawa, M; Ida, M; Kakizawa, H; Kojima, S; Kuroda, Y; Maeda, H; Matsui, F; Nakanishi, K; Oohira, A; Saito, A; Sato, Y; Tokita, Y | 1 |
| Bigini, P; De Paola, M; Diana, V; Mennini, T | 1 |
| Ampagoomian, D; Beique, JC; Faraday, N; Gozen, O; Huganir, R; Ikeda, M; Lowenstein, CJ; Martin, TV; Mason, E; Morrell, CN; Rothstein, J; Sprengel, R; Sun, H; Swaim, AM; Thompson, LE | 1 |
| Ai, YX; Chang, DC; Fu, HJ; Han, YF; Lao, YZ; Li, CY; Li, WM; Li, ZW; Liu, LJ; Liu, YW; Luo, JL; Pang, YP; Peoples, RW | 1 |
| Kass-Simon, G; Scappaticci, AA | 1 |
| Denbow, DM; Furuse, M; Tsuneyoshi, Y; Yamane, H | 1 |
| Biondolillo, JW; King, MS; Williams, LA | 1 |
| Di Cosmo, A; Di Cristo, C; Moccia, F; Winlow, W | 1 |
| Champeil, E; Proni, G; Sapse, D | 1 |
| Feligioni, M; Henley, JM; Nishimune, A | 1 |
| Jantas, D; Jaworska-Feil, L; Lason, W; Lipkowski, AW | 1 |
| Bhatt, D; Chung, WY; Cooper, RL; Lee, JY | 1 |
| Kim, M; Luccarelli, J; Schmitz, Y; Sulzer, D; Wang, M | 1 |
| Lash-Van Wyhe, LL; Pentikäinen, OT; Postila, PA; Sakai, R; Sasaki, M; Swanson, GT; Tsubone, K | 1 |
| Chen, L; Cho, JH; Chow, RH; Hille, B; Kim, MH; Koh, DS | 1 |
| Holland, PT; Kerr, DS; Mountfort, DO; Peake, BM; Sawant, PM; Tyndall, JD | 1 |
| Bender, C; de Olmos, JS; de Olmos, S; Lorenzo, A; Rassetto, M | 1 |
| Bulley, S; Shen, W | 1 |
| Balduzzi, M; Bellenchi, GC; Cammarota, R; Carnovale-Scalzo, G; De Nuccio, C; Di Stasi, AM; Frank, C; Leo, L; Malchiodi-Albedi, F; Mallozzi, C; Matteucci, A; Paradisi, S; Scorcia, G; Varano, M; Visentin, S | 1 |
| Benquet, P; Demont-Guignard, S; Huneau, C; Martin, B; Wendling, F | 1 |
| Belan, P; Kao, SC; Kopach, O; Petralia, RS; Tao, YX; Voitenko, N | 1 |
| Chen, P; Farooqui, AA; Ong, WY; Tan, Y; Than, A | 1 |
| Basuroy, S; Fedinec, AL; Leffler, CW; Liu, J; Parfenova, H; Tcheranova, D | 1 |
| Contó, MB; Venditti, MA | 1 |
| Andrade-Talavera, Y; Duque-Feria, P; Flores, G; Negrete-Díaz, JV; Rodríguez-Moreno, A; Sihra, TS | 1 |
| Kalinina, NI; Kurchavyĭ, GG; Veselkin, NP | 1 |
| Bhargava, A; Gong, K; Jasmin, L; Kung, LH; Magni, G | 1 |
| Fukushima, K; Imaizumi, Y; Ito, M; Kohmura, N; Sawada, K; Sugawara, M; Tabata, Y; Yamazaki, K | 1 |
| Jaryal, AK; Mallick, HN; Sengupta, T | 1 |
| Artigas, F; Castañé, A; Gasull-Camós, J; Tarrés-Gatius, M | 1 |
| Gartner, JJ; Prickett, TD; Samuels, Y | 1 |
| Avendaño, C; Fernández-Montoya, J; Negredo, P | 1 |
| Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P | 1 |
| Barresi, M; Baufreton, J; Fioramonti, S; Frick, A; Froux, L; Le Bon-Jego, M; Miguelez, C; Morin, S; Normand, E; Taupignon, A | 1 |
| Eyigor, O; Gok-Yurtseven, D; Kafa, IM; Minbay, Z | 1 |
| Benke, TA; Castano, A; O'Leary, H; Saba, LM; Southard, L; Vanderlinden, L | 1 |
| Blain, EJ; Bonnet, CS; Gilbert, SJ; Mason, DJ; Williams, AS | 1 |
| Ábrahám, IM; Cho, DH; Han, SK; Jang, SH; Park, SA; Rijal, S | 1 |
| Brüll, M; Falt, T; Karreman, C; Klima, S; Leist, M; Schwamborn, JC; Spreng, AS; Suciu, I; Waldmann, T | 1 |
| Collingridge, GL; Monaghan, DT | 1 |
| Čikoš, Š; Fabian, D; Koppel, J; Kovaříková, V; Kšiňanová, M; Pisko, J; Šefčíková, Z; Špirková, A | 1 |
| Flores-Soto, M; González-Burgos, I; Martínez-Torres, NI; Salgado-Ceballos, H; Tejeda-Martínez, A; Vázquez-Hernández, N | 1 |
| Chang, A; Chang, Y; Wang, SJ | 1 |
9 review(s) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Effect of GABAergic and glutamatergic drugs injected into the ventral pallidum on locomotor activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Ibotenic Acid; Kainic Acid; Motor Activity; Muscimol; N-Methylaspartate; Picrotoxin | 1991 |
The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Humans; Kainic Acid | 1994 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Epilepsy; Ibotenic Acid; Kainic Acid; Ligands; N-Methylaspartate; Receptors, Amino Acid; Signal Transduction; Transcription Factors | 1993 |
Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Baroreflex; Cardiovascular Physiological Phenomena; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Solitary Nucleus | 1997 |
[Stimulating amino acids in epilepsy: possibilities of treatment].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Asparagine; Epilepsy; Female; Glutamine; Humans; Kainic Acid; Male; N-Methylaspartate; Synaptic Transmission | 2000 |
Inhibitors of AMPA and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Epilepsy; Humans; Kainic Acid; Receptors, AMPA; Receptors, Kainic Acid | 2001 |
Acute treatments: future developments.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcitonin Gene-Related Peptide; Forecasting; Humans; Kainic Acid; Migraine Disorders; Nitric Oxide Synthase; Serotonin Receptor Agonists | 2001 |
The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ganglia, Sensory; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neuralgia; Neuronal Plasticity; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Synaptic Transmission | 2017 |
752 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid
| Article | Year |
|---|---|
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil | 1997 |
Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines.
Topics: Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isomerism; Models, Chemical; N-Methylaspartate; Phencyclidine; Quinoxalines; Radioligand Assay; Rats; Receptors, AMPA; Structure-Activity Relationship; Tyrosine | 1997 |
Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallography, X-Ray; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Furans; In Vitro Techniques; Isoxazoles; Photoaffinity Labels; Photochemistry; Rats; Receptors, AMPA; Stereoisomerism; Structure-Activity Relationship | 1998 |
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Topics: Animals; Convulsants; Excitatory Amino Acid Agonists; Isoxazoles; Mice; Pyrroles; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Structure-Activity Relationship | 1998 |
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Topics: Animals; Cerebral Cortex; Convulsants; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Proline; Pyrroles; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism | 1999 |
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Substitution; Animals; Crystallography, X-Ray; Excitatory Amino Acid Agonists; Female; Kainic Acid; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Ovary; Protein Conformation; Protein Structure, Secondary; Receptors, AMPA; Recombinant Proteins; Xenopus laevis | 2003 |
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Topics: Alanine; Animals; Animals, Newborn; Calcium; Cell Line; Humans; In Vitro Techniques; Long-Term Potentiation; Mossy Fibers, Hippocampal; Nerve Fibers, Unmyelinated; Protein Subunits; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Structure-Activity Relationship; Uracil | 2005 |
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Topics: Animals; Cell Line; Crystallography, X-Ray; Drug Design; Excitatory Amino Acid Agonists; Humans; Models, Molecular; Propionates; Receptors, Kainic Acid; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2009 |
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Ligands; Rats; Receptors, AMPA; Synaptosomes; Triazoles | 2019 |
Heterocyclic excitatory amino acids. Synthesis and biological activity of novel analogues of AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain; Electrophysiology; Heterocyclic Compounds; Ibotenic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1992 |
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Dizocilpine Maleate; Glycine; Ibotenic Acid; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Male; Molecular Structure; Neurons; Propionates; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1991 |
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Crystallography, X-Ray; Dizocilpine Maleate; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Rats; Receptors, AMPA; Stereoisomerism | 1994 |
Syntheses and conformational analyses of glutamate analogs: 2-(2-carboxy-3-substituted-cyclopropyl)glycines as useful probes for excitatory amino acid receptors.
Topics: Animals; Central Nervous System; Glutamates; Glycine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Probes; Rats; Receptors, Glutamate | 1996 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Topics: Animals; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Humans; Ligands; Molecular Structure; Oocytes; Pyrimidinones; Rats; Receptors, Glutamate; Spodoptera; Structure-Activity Relationship; Thiophenes; Xenopus laevis | 2008 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Topics: Allosteric Regulation; Animals; Binding Sites; Ligands; Receptors, AMPA | 2010 |
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
Topics: Amino Acids, Acidic; Animals; Brain; Cell Line; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Oocytes; Oxadiazoles; Patch-Clamp Techniques; Potentiometry; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2010 |
Excitatory amino acid-mediated responses and synaptic potentials in medial pontine reticular formation neurons of the rat in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pons; Rats; Rats, Inbred Strains; Reticular Formation; Synapses | 1992 |
Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Membrane Potentials; Oocytes; Quinoxalines; Receptors, AMPA; Receptors, Neurotransmitter; Recombinant Proteins; Xenopus laevis | 1992 |
Preferential activation of [3H]phorbol-12,13-dibutyrate binding by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Corpus Striatum; Cycloleucine; Glial Fibrillary Acidic Protein; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344 | 1992 |
Time course of glutamate receptor expression in individual oocytes of Xenopus laevis after injection of rat brain RNA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electrophysiology; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, Glutamate; RNA, Messenger; Xenopus laevis | 1992 |
Neuroscientists begin to piece together more parts of Huntington's disease puzzle.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Chemistry; Disease Models, Animal; Fibroblast Growth Factors; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Lactates; Lactic Acid; Rats | 1992 |
Agonist- and subunit-dependent potentiation of glutamate receptors by a nootropic drug aniracetam.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Membrane Potentials; Oocytes; Psychotropic Drugs; Pyrrolidinones; Rats; Receptors, Glutamate; Xenopus laevis | 1992 |
Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoxazoles; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Oocytes; Propionates; Receptors, Amino Acid; RNA, Messenger; Stereoisomerism; Xenopus laevis | 1992 |
Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane Permeability; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Transport; Kainic Acid; Pyramidal Tracts; Rats; Receptors, Glutamate | 1992 |
Tunicamycin-induced inhibition of functional expression of glutamate receptors in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Ibotenic Acid; Ion Channels; Kainic Acid; Oligosaccharides; Oocytes; Quisqualic Acid; Receptors, Glutamate; RNA; Tunicamycin; Xenopus laevis | 1992 |
1,10-Diaminodecane and 1,12-diaminododecane block NMDA receptor currents by an open channel mechanism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Diamines; Electrophysiology; Female; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
Evidence that [3H]glutamate binding sites are masked by biologically relevant endogenous factor on cell membranes of frog spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Membrane; Cytosol; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Piperazines; Quisqualic Acid; Rana catesbeiana; Spinal Cord | 1992 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors | 1992 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Axons; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil | 1992 |
Transmitter-operated channels in rabbit retinal astrocytes studied in situ by whole-cell patch clamping.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Bicuculline; Chloride Channels; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; Membrane Proteins; Quisqualic Acid; Rabbits; Receptors, GABA-A; Retina; Time Factors | 1992 |
Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Evoked Potentials; Female; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Synapses; Xenopus | 1992 |
Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholera Toxin; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Pertussis Toxin; Quisqualic Acid; Time Factors; Virulence Factors, Bordetella | 1992 |
In the GluR1 glutamate receptor subunit a glutamine to histidine point mutation suppresses inward rectification but not calcium permeability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Barium; Base Sequence; Calcium; Calcium Channels; Cloning, Molecular; Evoked Potentials; Glutamates; Glutamine; Histidine; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oocytes; Plasmids; Quinoxalines; Receptors, Glutamate; Receptors, Neurotransmitter; Transcription, Genetic; Xenopus laevis | 1992 |
Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Cloning, Molecular; DNA; Ibotenic Acid; Ion Channels; Isomerism; Kainic Acid; Molecular Sequence Data; Nucleic Acid Hybridization; Oocytes; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Transcription, Genetic | 1992 |
alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonists in the nucleus accumbens and ventral pallidum decrease the hypermotility response to psychostimulant drugs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Globus Pallidus; Glutamine; Ibotenic Acid; Kainic Acid; Male; Motor Activity; Nucleus Accumbens; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1992 |
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chlorides; Electrophysiology; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retinal Ganglion Cells; Sodium | 1992 |
Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neu
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Dantrolene; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Verapamil | 1992 |
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Electrophysiology; Feedback; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; Nerve Tissue Proteins; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Trigeminal Caudal Nucleus | 1992 |
Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Calcium; Cells, Cultured; Fluorescent Antibody Technique; Ibotenic Acid; Kainic Acid; Membrane Potentials; Purkinje Cells; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biguanides; Cations, Divalent; Cells, Cultured; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Cell Membrane; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1992 |
Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Kainic Acid; Ligands; Macromolecular Substances; Molecular Weight; Nerve Tissue Proteins; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus laevis | 1992 |
Effects of acromelic acid A on the binding of [3H]-kainic acid and [3H]-AMPA to rat brain synaptic plasma membranes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Female; Ibotenic Acid; Kainic Acid; Kinetics; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Synaptic Membranes | 1992 |
CNQX binding to non-NMDA glutamate receptors in canine cerebro-cortical crude synaptosomal membranes: pharmacological characterization and comparison of binding parameters in dogs with congenital portosystemic encephalopathy and control dogs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Dogs; Female; Hepatic Encephalopathy; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; Membranes; Quinoxalines; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Glutamic acid-insensitive [3H]kainic acid binding in goldfish brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; Ligands; Neurotoxins; Tissue Distribution; Tritium | 1992 |
Purification of AMPA type glutamate receptor by a spider toxin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cattle; Cerebellum; Chloride Channels; Chromatography, Affinity; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Liposomes; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Quisqualic Acid; Receptors, AMPA; Receptors, Neurotransmitter; Spider Venoms | 1992 |
NMDA treatment and K(+)-induced depolarization selectively promote the expression of an NMDA-preferring class of the ionotropic glutamate receptors in cerebellar granule neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Survival; Cells, Cultured; Cerebellar Cortex; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1992 |
Failure of a protein synthesis inhibitor to modify glutamate receptor-mediated neurotoxicity in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anisomycin; Cell Death; Glutamate Decarboxylase; Glutamates; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Protein Biosynthesis; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Gamma-D-glutamylaminomethyl sulfonic acid (GAMS) distinguishes subtypes of glutamate receptor in the chick cochlear nucleus (nuc. magnocellularis).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Chickens; Cochlea; Glutamates; Glutamic Acid; Glutamine; Ibotenic Acid; Kainic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Ethanol; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oocytes; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus laevis | 1992 |
Compartmentalization of excitatory amino acid receptors in human striatum.
Topics: Acetylcholinesterase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Caudate Nucleus; Corpus Striatum; Dizocilpine Maleate; Female; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Putamen; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tritium | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Glutamates; Ibotenic Acid; Kainic Acid; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Recombinant Proteins; Sequence Homology, Nucleic Acid; Xenopus laevis | 1992 |
The effects of kainate and the glutamate agonist, AMPA, are not separable in rat neocortical cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Neurons; Pregnancy; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1992 |
Domoic acid toxicity in rats and mice after intracerebroventricular administration: comparison with excitatory amino acid agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains | 1992 |
Evoked endogenous taurine release from cultured cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
Evidence for a glutamate receptor of the AMPA subtype which mediates insulin release from rat perfused pancreas.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Insulin; Kainic Acid; Male; Pancreas; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1992 |
Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Methohexital; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Induction of cobalt accumulation by excitatory amino acids within neurons of the hippocampal slice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cobalt; Gerbillinae; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; N-Methylaspartate; Neurons | 1992 |
Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Molecular Conformation; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter; Structure-Activity Relationship | 1992 |
NMDA-induced release of nitric oxide potentiates aspartate overflow from cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Aspartic Acid; Cerebellum; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Glycoproteins; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neuronal Plasticity; Phospholipases A; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Amygdala; Animals; Bicuculline; Brain Mapping; Carbachol; Dominance, Cerebral; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Ibotenic Acid; Kainic Acid; Limbic System; Muscimol; Quisqualic Acid; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1992 |
Polyamine spider toxins are potent un-competitive antagonists of rat cortex excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Ibotenic Acid; In Vitro Techniques; Indoleacetic Acids; Kainic Acid; Male; N-Methylaspartate; Polyamines; Rats; Receptors, Neurotransmitter; Spider Venoms; Xenopus laevis | 1992 |
Selective alterations in glutamate receptor subtypes after unilateral orbital enucleation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Eye Enucleation; Functional Laterality; Glutamates; Ibotenic Acid; Kainic Acid; Male; Ocular Physiological Phenomena; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Purinergic; Reference Values; Time Factors; Tritium; Visual Cortex; Visual Pathways | 1991 |
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Brain Chemistry; Cerebellum; Cloning, Molecular; DNA; Ibotenic Acid; Kainic Acid; Mice; Molecular Sequence Data; Nucleic Acid Hybridization; Oocytes; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Tissue Distribution; Transfection; Xenopus | 1991 |
Non-NMDA excitatory amino acid receptors in a subcellular fraction enriched in cerebellar glomeruli.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cells, Cultured; Cerebellum; Female; Glutamates; Ibotenic Acid; Kainic Acid; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1991 |
Autoradiographic localisations of glutamatergic ligand binding sites in Xenopus brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding Sites; Brain Chemistry; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus | 1991 |
Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Cells, Cultured; Cerebellum; Cytosol; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1991 |
A single amino acid residue determines the Ca2+ permeability of AMPA-selective glutamate receptor channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Calcium Channels; Glutamates; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Membrane Potentials; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oocytes; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1991 |
Excitatory amino acids: new tools for old stories or pharmacological subtypes of glutamate receptors: electrophysiological studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain Stem; Cerebral Cortex; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Polyamines; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Wasp Venoms | 1991 |
Vintage amino acid meeting describes new tools for amino acid research, subtypes of metabotropic receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Humans; Ibotenic Acid; Kainic Acid; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Activation of AMPA/kainic acid glutamate receptors in the zona incerta stimulates locomotor activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diencephalon; Ibotenic Acid; Injections; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Neurotransmitter; Substantia Nigra | 1991 |
Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; Membranes; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stimulation, Chemical | 1991 |
2,4,5-Trihydroxyphenylalanine (6-hydroxy-dopa) displaces [3H]AMPA binding in rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Corpus Striatum; Dihydroxyphenylalanine; Ibotenic Acid; Kainic Acid; Kinetics; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Tritium | 1991 |
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Caudate Nucleus; Cell Death; Child; Dizocilpine Maleate; Frontal Lobe; Glycine; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Phencyclidine; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1991 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Cycloleucine; Embryo, Mammalian; Glutamates; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
Transient postnatal increases in excitatory amino acid binding sites in rat ventral mesencephalon.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Corpus Striatum; Glutamates; Ibotenic Acid; Kainic Acid; Mesencephalon; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Acetylcholine release from the rabbit retina mediated by kainate receptors.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Choline; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rabbits; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina | 1991 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Release of endogenous and newly synthesized glutamate and of other amino acids induced by non-N-methyl-D-aspartate receptor activation in cerebellar granule cell cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Exocytosis; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Potassium; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Taurine | 1991 |
Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Mice; Neurons; Quisqualic Acid; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1991 |
Alterations in cortical [3H]kainate and alpha-[3H]amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding in a spontaneous canine model of chronic hepatic encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Chronic Disease; Dizocilpine Maleate; Dogs; Glutamates; Glutamic Acid; Hepatic Encephalopathy; Ibotenic Acid; Kainic Acid; Ligands; Tritium | 1991 |
Differential intracellular calcium responses to glutamate in type 1 and type 2 cultured brain astrocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Calcium; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Glial Fibrillary Acidic Protein; Glutamates; Ibotenic Acid; Immunohistochemistry; Kainic Acid; Potassium; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Autoradiographic characterization of [3H]L-glutamate binding sites in developing mouse cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Binding, Competitive; Calcium; Cerebellar Cortex; Chlorides; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Protein Binding; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1991 |
NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary pressor area.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Convulsants; Glutamates; Glutamic Acid; Heart Rate; Ibotenic Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Myocardial Contraction; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
Presynaptic modulation of glutamate and dynorphin release by excitatory amino acids in the guinea-pig hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dynorphins; Glutamates; Guinea Pigs; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Potassium; Quinoxalines; Quisqualic Acid; Synapses; Synaptosomes | 1991 |
GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Cerebellum; Chlorides; Cyclic GMP; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Lithium; Lithium Chloride; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Nipecotic Acids; Nitroprusside; Organic Anion Transporters; Proline; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Secretory Rate; Sodium; Stimulation, Chemical | 1991 |
Quisqualate agonists occlude kainate-induced current in cultured striatal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cells, Cultured; Corpus Striatum; Drug Interactions; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Neurons; Quisqualic Acid | 1991 |
Solubilization, characterization, and partial purification of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-, quisqualate-, kainate-sensitive L-glutamate binding sites from porcine brain synaptic junctions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Chromatography; Detergents; Glutamates; Glutamic Acid; Hot Temperature; Ibotenic Acid; Kainic Acid; Octoxynol; Polyethylene Glycols; Quisqualic Acid; Solubility; Synapses | 1991 |
Excitatory amino acid receptors mediate synaptic responses to visual stimuli in superior colliculus neurones of the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Neurons; Photic Stimulation; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1991 |
Excitatory synapse in the rat hippocampus in tissue culture and effects of aniracetam.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Embryo, Mammalian; Evoked Potentials; Hippocampus; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Pyramidal Tracts; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1991 |
Excitotoxicity in the embryonic chick spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinoxalines; Quisqualic Acid; Spinal Cord | 1991 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Capsaicin; Functional Laterality; Hot Temperature; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neuronal Plasticity; Neuropeptides; Pain; Quinoxalines; Rats; Reflex; Time Factors | 1991 |
The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Chloride; Cortical Spreading Depression; Electric Stimulation; Evoked Potentials; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors; Visual Cortex | 1991 |
Intercellular action of nitric oxide in adult rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Hemoglobins; Hydroxylamine; Hydroxylamines; Ibotenic Acid; Kainic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S-Nitroso-N-Acetylpenicillamine | 1991 |
Vinpocetine preferentially antagonizes quisqualate/AMPA receptor responses: evidence from release and ligand binding studies.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membranes; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tritium; Vinca Alkaloids | 1991 |
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Cerebellum; Electric Conductivity; Glycine; Hydrogen-Ion Concentration; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Protons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P | 1990 |
Glutamate: three meetings but how many receptors? Excitatory Amino Acids 1990: a Fidia Research Foundation Symposium, Padua, Italy, May 21-26, 1990. Excitatory Amino Acid Receptors in the Brain: Functions and Disorders, Montreal, Canada, June 23-24, 1990.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; GTP-Binding Proteins; Ibotenic Acid; Ion Channel Gating; Ion Channels; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction | 1990 |
AMPA and kainate-operated channels reconstituted in artificial bilayers.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Membrane; Cholesterol; Electric Conductivity; Ibotenic Acid; Ion Channels; Kainic Acid; Lipid Bilayers; Membrane Potentials; Phosphatidylcholines; Phospholipids; Receptors, Kainic Acid; Receptors, Neurotransmitter; Xenopus | 1991 |
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Ibotenic Acid; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Xenopus | 1991 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Mesencephalon; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Substance P | 1991 |
Functional expression of the alpha 1 subunit of the AMPA-selective glutamate receptor channel, using a baculovirus system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baculoviridae; DNA, Recombinant; Gene Expression; Genetic Vectors; Glutamates; Glutamic Acid; Ibotenic Acid; Insecta; Ion Channels; Kainic Acid; Kinetics; Mice; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Transfection | 1991 |
Desensitization and resensitization rates of glutamate-activated channels may regulate motoneuron excitability.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Chick Embryo; Electrophysiology; Glutamates; Ibotenic Acid; Ion Channels; Kainic Acid; Motor Neurons; Quinoxalines; Quisqualic Acid; Synaptic Transmission | 1991 |
Potentiation of a behavioural response in mice by spinal coadministration of substance P and excitatory amino acid agonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Behavior, Animal; Drug Synergism; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nociceptors; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Substance P | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Depression of a sustained calcium current by kainate in rat hippocampal neurones in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Barium; Calcium; Culture Techniques; Egtazic Acid; Electrophysiology; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Neurons; Rats; Rats, Inbred Strains; Sodium | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; Indicators and Reagents; Kainic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Tetrazoles | 1991 |
Kainic acid neurotoxicity: in vivo test of two new non-N-methyl-D-aspartate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Corpus Striatum; Hippocampus; Isoxazoles; Kainic Acid; Male; Nervous System Diseases; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Molecular cloning and characterization of the rat NMDA receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Electrophysiology; Ibotenic Acid; Kainic Acid; Molecular Sequence Data; Molecular Structure; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus | 1991 |
Comparison of solubilised kainate and alpha-amino-3-hydroxy-5- methylisoxazolepropionate binding sites in chick cerebellum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Cerebellum; Chickens; Glucosides; Ibotenic Acid; Kainic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Solubility | 1991 |
Modulation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/quisqualate receptors by phospholipase A2: a necessary step in long-term potentiation?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Western; Calpain; Cell Membrane; Cerebellum; Electric Stimulation; Evoked Potentials; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter; Spectrin | 1991 |
Interaction of 5-bromowillardiine with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chickens; Female; Ibotenic Acid; Injections; Kainic Acid; Membrane Potentials; Neuromuscular Depolarizing Agents; Oocytes; Quisqualic Acid; Receptors, Dopamine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1991 |
Development of binding sites for excitatory amino acids in cultured cerebral cortex neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; DNA; Female; Glutamates; Ibotenic Acid; Kainic Acid; Kinetics; Membrane Potentials; Membranes; Mice; Neurons; Pregnancy | 1991 |
Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Benzoxazines; Binding Sites; Female; Glutamates; Hippocampus; Humans; Ibotenic Acid; Kainic Acid; Male; Neurons; Oxazines | 1991 |
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Computer Simulation; Ibotenic Acid; Kainic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1990 |
Modulation of non-N-methyl-D-aspartate receptors in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Granulocytes; Ibotenic Acid; Kainic Acid; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ammonia; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Down-Regulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Liver; Male; N-Methylaspartate; Organ Size; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1990 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; Muscle Proteins; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Oxazoles; Parvalbumins; Somatostatin | 1990 |
(2S,3S,4S) alpha-(carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Electric Stimulation; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred F344; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptosomes | 1990 |
Homomeric GluR1 excitatory amino acid receptors expressed in Xenopus oocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Ganglia, Spinal; Hippocampus; Ibotenic Acid; Kainic Acid; Membrane Proteins; Oocytes; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Xenopus | 1990 |
The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Cyanobacteria Toxins; Glutamine; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Kinetics; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Receptors, Drug; Receptors, N-Methyl-D-Aspartate | 1990 |
On concanavalin A-treated striatal neurons quisqualate clearly behaves as a partial agonist of a receptor fully activated by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Concanavalin A; Corpus Striatum; Female; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; Mice; Neurons; Pregnancy; Quinoxalines; Quisqualic Acid; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Veratridine | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Neurotransmitter | 1990 |
Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Ethanol; Female; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Rats; Rats, Inbred Strains | 1991 |
A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Chickens; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Retina; Retinal Ganglion Cells; Vitreous Body | 1990 |
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Female; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Polyamines; Quisqualic Acid; Rats; Rats, Inbred Strains; Wasp Venoms | 1990 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hypoglycemia; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Aspartic Acid; Autoradiography; Cerebral Cortex; Female; Glutamates; Humans; Ibotenic Acid; Kainic Acid; Male; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Tritium | 1990 |
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium Channels; Drug Antagonism; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nifedipine; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A family of AMPA-selective glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Base Sequence; Brain; Glutamates; Ibotenic Acid; Kainic Acid; Kinetics; Molecular Sequence Data; Multigene Family; Oligonucleotide Probes; Organ Specificity; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Sequence Homology, Nucleic Acid | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Selective stimulation of excitatory amino acid receptor subtypes and the survival of cerebellar granule cells in culture: effect of kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Dizocilpine Maleate; DNA; Electric Stimulation; Glutamine; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Potassium; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Antibodies to a C-terminal peptide of the rat brain glutamate receptor subunit, GluR-A, recognize a subpopulation of AMPA binding sites but not kainate sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Antibodies; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Glutamates; Ibotenic Acid; Kainic Acid; Kinetics; Molecular Sequence Data; Peptide Fragments; Peptides; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Modulation of DL-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/quisqualate receptors by phospholipase A2 treatment.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Phospholipases A; Phospholipases A2; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter; Synaptic Membranes; Tritium | 1990 |
NMDA and kainic acid receptors have a complementary distribution to AMPA receptors in the human cerebellum.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Cerebellum; Female; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Excitotoxin-induced degeneration of rat vagal afferent neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Ibotenic Acid; Kainic Acid; Nerve Degeneration; Neurons, Afferent; Nodose Ganglion; Pressoreceptors; Rats; Rats, Inbred Strains; Vagus Nerve | 1990 |
Non-NMDA receptor-mediated neurotoxicity in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; Ibotenic Acid; Kainic Acid; Microscopy, Phase-Contrast; Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Time Factors; Zinc | 1990 |
AMPA, kainate, and quisqualate activate a common receptor-channel complex on embryonic chick motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Binding, Competitive; Chick Embryo; Ibotenic Acid; Ion Channels; Kainic Acid; Motor Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Receptors, Cell Surface | 1988 |
A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Convulsants; Female; Ibotenic Acid; Kainic Acid; Kinetics; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA; Xenopus laevis | 1989 |
Horizontal cells isolated from catfish retina contain two types of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Cations, Divalent; Cell Membrane Permeability; Cells, Cultured; Concanavalin A; Convulsants; Glutamates; Ibotenic Acid; Ictaluridae; Ion Channels; Kainic Acid; Membrane Potentials; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Valine; Zinc | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Electrophysiology; Ibotenic Acid; Kainic Acid; Male; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship; Synaptic Membranes | 1989 |
Antagonist profile of 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate at excitatory amino acid receptors in the neonatal rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ibotenic Acid; Kainic Acid; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1989 |
Beta-N-oxalylamino-L-alanine action on glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates | 1989 |
Synaptic localization of striatal NMDA, quisqualate and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Cerebral Decortication; Corpus Striatum; Glutamates; Histocytochemistry; Ibotenic Acid; Kainic Acid; Male; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Transient increase in ligand binding to quisqualate and kainate sites in cerebral cortex of immature rats.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Ibotenic Acid; Kainic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1989 |
Excitatory amino acid receptors in the human cerebral cortex: a quantitative autoradiographic study comparing the distributions of [3H]TCP, [3H]glycine, L-[3H]glutamate, [3H]AMPA and [3H]kainic acid binding sites.
Topics: Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Female; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Oxazoles; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chickens; Ibotenic Acid; Kainic Acid; Membrane Potentials; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1989 |
A voltage-clamp study of isolated stingray horizontal cell non-NMDA excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Separation; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Fishes; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Osmolar Concentration; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1989 |
Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Catfishes; Convulsants; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid | 1989 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Hypoglycemia; Ibotenic Acid; Insulin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Female; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1989 |
Biochemical characterization of an autoradiographic method for studying excitatory amino acid receptors using L-[3H]glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Software; Tritium | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Displacement of excitatory amino acid receptor ligands by acidic oligopeptides.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Frontal Lobe; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Evidence for a single glutamate receptor of the ionotropic kainate/quisqualate type.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Protein Conformation; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; Xenopus laevis | 1989 |
AMPA, kainic acid, and N-methyl-D-aspartic acid stimulate locomotor activity after injection into the substantia innominata/lateral preoptic area.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Dose-Response Relationship, Drug; Drug Interactions; Glutamine; Ibotenic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Oxazoles; Preoptic Area; Quinoxalines; Rats; Rats, Inbred Strains; Substantia Innominata | 1989 |
Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS.
Topics: 4-Quinolones; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Infective Agents; Aspartic Acid; Brain Chemistry; Calcium; Chlorides; Diazepam; gamma-Aminobutyric Acid; Glutamates; Ibotenic Acid; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1989 |
Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin636.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cerebral Cortex; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Indoleacetic Acids; Kainic Acid; Male; Membrane Potentials; Neurons; Phenylacetates; Polyamines; Rats; Rats, Inbred Strains | 1989 |
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Excitatory amino acid receptors and ischemic brain damage in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1987 |
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Interactions; Electrophysiology; Homocysteine; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1987 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex.
Topics: 2-Amino-5-phosphonovalerate; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Cell Membrane; Chlorides; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Temporal Lobe | 1988 |
Characterization and regional distribution of glutamatergic and cholinergic ligand binding sites in goldfish brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Cyprinidae; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; Ligands; Ocular Physiological Phenomena; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1988 |
CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Female; Hippocampus; Ibotenic Acid; Kainic Acid; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1988 |
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Cell Membrane; Cerebral Cortex; Ibotenic Acid; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Female; Ibotenic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Xenopus | 1988 |
Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Glutamates; Glutamine; Ibotenic Acid; Injections; Kainic Acid; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug | 1988 |
A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Embryo, Mammalian; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Glutamates; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Lithium; Lithium Chloride; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1988 |
Effect of GABAergic transmission in the subpallidal region on the hypermotility response to the administration of excitatory amino acids and picrotoxin into the nucleus accumbens.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Aspartic Acid; Basal Ganglia; Brain; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; Male; Motor Activity; Muscimol; N-Methylaspartate; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Septal Nuclei; Substantia Innominata; Synaptic Transmission | 1988 |
Glutamate receptors of ganglion cells in the rabbit retina: evidence for glutamate as a bipolar cell transmitter.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamates; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Light; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells | 1988 |
The ionic mechanisms associated with the excitatory response of kainate, L-glutamate, quisqualate, ibotenate, AMPA and methyltetrahydrofolate on leech Retzius cells.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane; Cell Membrane Permeability; Ganglia; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Leeches; Membrane Potentials; Neurons; Osmolar Concentration; Oxadiazoles; Oxazoles; Pyrrolidines; Quisqualic Acid; Sodium; Tetrahydrofolates | 1984 |
Effect of glutamic acid diethylester on (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid-induced changes of body temperature in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Glutamates; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Oxazoles; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Electrophysiology; Excitatory Amino Acid Agonists; Gerbillinae; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Neurons; Neurotoxins; Patch-Clamp Techniques; Spider Venoms; Synapses | 1995 |
L-glutamate-induced changes in intracellular calcium oscillation frequency through non-classical glutamate receptor binding in cultured rat myocardial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Intracellular Fluid; Kainic Acid; Myocardium; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
Neurotoxicity of acromelic acid in cultured neurons from rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cells, Cultured; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; Rats, Wistar; Spinal Cord | 1995 |
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Central Nervous System Diseases; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Rats; Receptors, Amino Acid; Riluzole; Thiazoles | 1995 |
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Kainic Acid; Nerve Degeneration; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ethanol; Female; Humans; Kainic Acid; Kidney; Membrane Potentials; Neurons; Pregnancy; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Transfection | 1993 |
Functional kainate-selective glutamate receptors in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Embryo, Mammalian; Hippocampus; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Pharmacological evidence for involvement of excitatory amino acids in aversive responses induced by intrathecal substance P in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Biphenyl Compounds; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P | 1993 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
AMPA/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Dopamine; Dopamine Agents; Dopamine Antagonists; Ergolines; Glutamine; Injections; Kainic Acid; Male; Motor Activity; Nerve Endings; Nucleus Accumbens; Quinoxalines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid | 1993 |
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Electric Stimulation; Kainic Acid; Ketamine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons, Afferent; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Rats; Rats, Wistar | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slices.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electric Stimulation; Female; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rabbits; Receptors, Glutamate | 1993 |
Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Diazepam; Hippocampus; Injections; Kainic Acid; Limbic System; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Phospholipase A2 enhances [3H]AMPA binding to a putative homomeric GluR-B receptor in the rat spinal cord.
Topics: Acetophenones; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Autoradiography; Kainic Acid; Phospholipases A; Phospholipases A2; Rats; Receptors, Glutamate; Recombinant Proteins; Spinal Cord; Tritium | 1994 |
Glutamate- and AMPA-mediated calcium influx through glutamate receptor channels in medial septal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Calcium; Calcium Channels; Dendrites; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Membrane Potentials; Neurons; Prosencephalon; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1993 |
Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Blotting, Northern; Cell Line; Kainic Acid; Oligodendroglia; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Transcription, Genetic | 1994 |
The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Feeding Behavior; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 1993 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cloning, Molecular; Humans; Kainic Acid; Oocytes; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Xenopus laevis | 1994 |
Dexamethasone potentiates NMDA receptor-mediated neuronal injury in the postnatal rat.
Topics: Aldosterone; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Blood Glucose; Brain; Dexamethasone; Electron Transport Complex IV; Glutamates; Glutamic Acid; Kainic Acid; Metyrapone; N-Methylaspartate; Neurotransmitter Agents; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrophysiology; Glutamates; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1994 |
Evidence that GYKI 52466, a novel non-NMDA antagonist enhances the decay of kainate-induced current in cultured chicken cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Chick Embryo; Electrophysiology; Excitatory Amino Acid Antagonists; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines | 1994 |
AMPA/kainate receptor-mediated damage to NADPH-diaphorase-containing neurons is Ca2+ dependent.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Kainic Acid; Mice; NADPH Dehydrogenase; Nerve Degeneration; Neurons; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cerebellum; Concanavalin A; Cytoplasmic Granules; Electrophysiology; In Vitro Techniques; Ion Channels; Kainic Acid; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1994 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate differently affect neuronal cytoarchitecture of rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Cerebellum; Kainic Acid; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1994 |
The WAG/Rij rat model for nonconvulsive absence epilepsy: involvement of nonNMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Epilepsy, Absence; Female; Glutamates; Injections, Intraventricular; Kainic Acid; Kynurenic Acid; Male; Rats; Rats, Mutant Strains; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Interactions between NMDA and nonNMDA receptors in nonconvulsive epilepsy in the WAG/Rij inbred strain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Female; Glutamates; Injections, Intraventricular; Kainic Acid; Kynurenic Acid; Male; Rats; Rats, Mutant Strains; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1994 |
Selective loss of [3H]kainic acid and [3H]AMPA binding in layer VI of frontal cortex in Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Frontal Lobe; Humans; Huntington Disease; Kainic Acid; Middle Aged; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reference Values; Tritium | 1994 |
Non-NMDA receptor-mediated regulation of hypothalamic dopaminergic neurons in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Dopamine; Female; Hypothalamus; Kainic Acid; Male; Median Eminence; Neostriatum; Neurons; Paraventricular Hypothalamic Nucleus; Prolactin; Quinoxalines; Rats; Receptors, Amino Acid; Receptors, AMPA; Substantia Nigra | 1994 |
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Glycine; Hydrolysis; Kainic Acid; Kidney; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Cyclothiazide selectively potentiates AMPA- and kainate-induced [3H]norepinephrine release from rat hippocampal slices.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Drug Synergism; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tritium; Veratridine | 1994 |
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil | 1994 |
Hydrodynamic and pharmacological characterization of putative alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate-sensitive L-glutamate receptors solubilized from pig brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Centrifugation; Chromatography, Gel; Detergents; Kainic Acid; Octoxynol; Polyethylene Glycols; Receptors, Glutamate; Solubility; Swine; Thiocyanates | 1994 |
Memantine selectively depresses NMDA receptor-mediated responses of ratspinal neurones in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Dose-Response Relationship, Drug; Injections, Intravenous; Iontophoresis; Kainic Acid; Ketamine; Male; Memantine; Neurons; Nociceptors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Species-dependent functional properties of non-NMDA receptors expressed in Xenopus laevis oocytes injected with mammalian and avian brain mRNA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain Chemistry; Cattle; Chickens; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; Oocytes; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Species Specificity; Xenopus laevis | 1994 |
Effect of local infusion of glutamate analogues into the nucleus accumbens of rats: an electrochemical and behavioural study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrochemistry; Glutamates; Infusions, Parenteral; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Nomifensine; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Reserpine; Tetrodotoxin | 1994 |
Arachidonic acid depresses non-NMDA receptor currents.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Carrier Proteins; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; In Vitro Techniques; Kainic Acid; Molecular Sequence Data; Neoplasm Proteins; Nerve Tissue Proteins; Neurons; Purkinje Cells; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sequence Homology, Amino Acid; Synapses; Synaptic Transmission | 1994 |
Expression of non-NMDA glutamate receptor channel genes by clonal human neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Base Sequence; Blotting, Southern; Cell Differentiation; Clone Cells; DNA Primers; Gene Expression; Humans; Ion Channels; Kainic Acid; L-Lactate Dehydrogenase; Molecular Sequence Data; Neurons; Polymerase Chain Reaction; Quinoxalines; Receptors, Glutamate; Teratocarcinoma; Tretinoin; Tumor Cells, Cultured | 1994 |
Membrane topology of the GluR1 glutamate receptor subunit: epitope mapping by site-directed antipeptide antibodies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Antibodies; Brain; Columbidae; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Ferrets; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Macromolecular Substances; Male; Middle Aged; Molecular Sequence Data; Peptide Mapping; Peptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glutamate; Species Specificity; Synaptosomes; Tritium | 1994 |
High-level expression of functional glutamate receptor channels in insect cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baculoviridae; Cell Line; Detergents; Electrophysiology; Gene Expression; Gene Transfer Techniques; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Kinetics; Moths; Receptors, Glutamate | 1994 |
Selective RNA editing and subunit assembly of native glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Base Sequence; Cell Line; Cerebral Cortex; Codon; Electric Conductivity; Glutamates; Glutamic Acid; Humans; Immunosorbent Techniques; Ion Channels; Kainic Acid; Molecular Sequence Data; Oligodendroglia; Polymerase Chain Reaction; Rats; Receptors, Glutamate; RNA; RNA Editing; RNA Splicing; Stem Cells | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 1994 |
Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Dopamine; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; Perches; Pyrrolidinones; Quisqualic Acid; Receptors, Glutamate; Retina; Time Factors | 1994 |
Discrimination by added ions of ligands at ionotropic excitatory amino acid receptors insensitive to N-methyl-D-aspartate in rat brain using membrane binding techniques.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anions; Brain; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Amino Acid; Sulfhydryl Reagents; Synaptic Membranes; Thiocyanates | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Kainate binding to the AMPA receptor in rat brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain; Cell Membrane; Cytosol; Kainic Acid; Kinetics; Male; Protein Binding; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1994 |
The effects of L-glutamate, AMPA, quisqualate, and kainate on retinal horizontal cells depend on adaptational state: implications for rod-cone interactions.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adaptation, Physiological; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electric Conductivity; Excitatory Amino Acid Antagonists; Glutamates; Kainic Acid; Light; Male; Quinoxalines; Quisqualic Acid; Retina; Retinal Rod Photoreceptor Cells; Xenopus laevis | 1994 |
Possible role of glutamatergic neurotransmission in regulating ethanol-evoked brain ascorbate release.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ascorbic Acid; Brain Chemistry; Dicarboxylic Acids; Electrophysiology; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Male; Microelectrodes; N-Methylaspartate; Neostriatum; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Chondroitin sulfate proteoglycans protect cultured rat's cortical and hippocampal neurons from delayed cell death induced by excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Chondroitin Sulfates; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Proteoglycans; Rats; Rats, Sprague-Dawley | 1994 |
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction | 1994 |
Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria.
Topics: Adrenergic Fibers; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Atrial Function; Electric Stimulation; Female; Glutamates; Glutamic Acid; Heart Atria; Heart Rate; In Vitro Techniques; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Norepinephrine; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar | 1994 |
Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cytosol; Dizocilpine Maleate; Fetus; Glucose; Glutamic Acid; Glycine; Hypothermia, Induced; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurons | 1994 |
A novel photoaffinity ligand for kainate sites labels two polypeptides with molecular mass 45 and 33.5 kDa in chick cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Affinity Labels; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Azides; Binding, Competitive; Cell Membrane; Cerebellum; Chickens; Electrophoresis, Polyacrylamide Gel; Kainic Acid; Kinetics; Molecular Weight; Peptides | 1994 |
Interactions between N-acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dipeptides; Drug Interactions; Kainic Acid; N-Methylaspartate; Prosencephalon; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1994 |
Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Superior Colliculi | 1994 |
Basal forebrain cholinergic neurons are selectively vulnerable to AMPA/kainate receptor-mediated neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Choline O-Acetyltransferase; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Prosencephalon; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Rectification properties and Ca2+ permeability of glutamate receptor channels in hippocampal cells.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Dendrites; Hippocampus; Kainic Acid; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Changes in glutamate receptor and proenkephalin gene expression after kindled seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Blotting, Northern; Brain; Cerebellum; DNA Probes; Electric Stimulation; Enkephalins; Frontal Lobe; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Macromolecular Substances; Male; Organ Specificity; Parietal Lobe; Protein Precursors; Rats; Receptors, GABA; Receptors, Glutamate; RNA, Messenger; Seizures; Transcription, Genetic | 1994 |
The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Adhesion Molecules, Neuronal; Chromosome Mapping; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 19; Female; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Kainic Acid; Macromolecular Substances; Male; Mice; Mice, Inbred C57BL; Muridae; Rats; Receptors, Dopamine D2; Receptors, Glutamate; Species Specificity; Thy-1 Antigens | 1994 |
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Carrier Proteins; Computer Simulation; Electrophysiology; Glutamates; HeLa Cells; Humans; In Vitro Techniques; Kainic Acid; Ligands; Models, Molecular; Molecular Sequence Data; Oocytes; Quisqualic Acid; Receptors, Glutamate; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 1994 |
Sex differences in acute swim stress induced changes in the binding of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate to glutamate receptors in mouse forebrain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Female; Kainic Acid; Male; Mice; Prosencephalon; Receptors, Glutamate; Sex Characteristics; Stress, Physiological; Swimming; Synaptic Membranes; Synaptosomes; Tritium | 1994 |
Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ethanol; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Naloxone; Nucleus Accumbens; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Stable expression of a functional GluR6 homomeric glutamate receptor channel in mammalian cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Calcium; Cell Line; Cloning, Molecular; Cricetinae; DNA Primers; Electrophysiology; Kainic Acid; Molecular Sequence Data; Radioligand Assay; Rats; Receptors, Glutamate; Transfection | 1994 |
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Binding Sites; Binding, Competitive; Hippocampus; In Vitro Techniques; Isoquinolines; Kainic Acid; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Blotting, Northern; Brain; Gene Expression; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Lithium Chloride; Male; Molecular Sequence Data; Pilocarpine; Rats; Rats, Wistar; Receptors, AMPA; Status Epilepticus | 1994 |
NMDA and non-NMDA receptor-mediated release of [3H]GABA from granule cell dendrites of rat olfactory bulb.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Granulocytes; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1995 |
Increased hypothalamic glutamate receptors induced by water deprivation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Caudate Nucleus; Cell Membrane; Globus Pallidus; Hypothalamus; Kainic Acid; Putamen; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Tritium; Water Deprivation | 1994 |
The pyrimidine derivative BW 1003C87 protects against excitotoxic lesions induced by kainate in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Hippocampus; Kainic Acid; Lamotrigine; Male; Neostriatum; Nervous System Diseases; Neural Pathways; Pyrimidines; Rats; Rats, Wistar; Triazines | 1994 |
Effects of non-NMDA receptor modulators on [3H] dopamine release from rat mesencephalic cells in primary culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Dopamine; Drug Synergism; In Vitro Techniques; Kainic Acid; Mesencephalon; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
Synergy between diazepam and NBQX in preventing neuronal death caused by non-NMDA agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Diazepam; Drug Synergism; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 1994 |
NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1994 |
Autoradiographic characterization of [3H]6-cyano-7-nitroquinoxaline-2,3-dione binding sites in adult chick brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Cerebellum; Chickens; Excitatory Amino Acid Agonists; Kainic Acid; Kinetics; Nerve Tissue Proteins; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1994 |
NMDA, kainate, and AMPA depolarize nondopamine neurons in the rat ventral tegmentum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1995 |
Interactions of neurotoxins with non-NMDA glutamate receptors: an autoradiographic study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Autoradiography; beta-Alanine; Binding, Competitive; Dihydroxyphenylalanine; Hippocampus; Humans; Kainic Acid; Neurotoxins; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1994 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles | 1994 |
Taurine release from mouse hippocampal slices: effects of glutamatergic substances and hypoxia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Nitrogen; Oxygen; Potassium; Quisqualic Acid; Taurine | 1994 |
Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Polarity; Electroencephalography; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neostriatum; Rats; Rats, Sprague-Dawley | 1994 |
Release of [3H]GABA evoked by glutamate receptor agonists in cultured chick retina cells: effect of Ca2+.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Nicotinic Acids; Nipecotic Acids; Oximes; Quisqualic Acid; Retina; Tritium | 1994 |
Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Hot Temperature; Kainic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1994 |
Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin | 1994 |
Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane Permeability; Dendrites; Electric Conductivity; Hippocampus; Kainic Acid; Magnesium; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Zinc | 1995 |
Neuroprotective effect of free radical scavengers on beta-N-oxalylamino-L-alanine (BOAA)-induced neuronal damage in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Hippocampus; Kainic Acid; Male; Motor Neuron Disease; N-Methylaspartate; Neurons; Rats; Rats, Wistar | 1994 |
Cyclothiazide modulates AMPA receptor-mediated increases in intracellular free Ca2+ and Mg2+ in cultured neurons from rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Drug Synergism; Glutamic Acid; Kainic Acid; Magnesium; Neurons; Prosencephalon; Rats; Receptors, AMPA | 1995 |
Involvement of free radicals in excitotoxicity in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Death; Cells, Cultured; Cyclic N-Oxides; Dizocilpine Maleate; Electrophysiology; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Kainic Acid; Male; N-Methylaspartate; Neurons; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1995 |
The importance of two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Blotting, Western; Calcium; Cell Line; Cricetinae; Gene Expression; Kainic Acid; Kidney; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Transfection; Tritium | 1995 |
Effects of the epileptogenic agent strychnine on membrane currents elicited by agonists of the NMDA and non-NMDA receptors in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Glycine; Ion Channels; Kainic Acid; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Xenopus laevis | 1995 |
Felbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; Felbamate; Hippocampus; Kainic Acid; Kynurenic Acid; Lamotrigine; Male; N-Methylaspartate; Pentobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Triazines | 1995 |
Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gene Expression; In Situ Hybridization; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Photoreceptor Cells; Receptors, Glutamate; Retina | 1995 |
A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Hippocampus; Kainic Acid; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Synaptosomes | 1995 |
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Fetus; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Kinetics; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins | 1995 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
Dopamine enhances glutamate-activated currents in spinal motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Base Sequence; Benzazepines; Chick Embryo; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; Glutamic Acid; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; Molecular Sequence Data; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Polymerase Chain Reaction; Receptors, Dopamine D1; RNA, Messenger; Spinal Cord; Time Factors | 1995 |
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Cell Line; Gene Expression; Glutamic Acid; Ion Channels; Kainic Acid; Molecular Sequence Data; Neurotoxins; Oligodendroglia; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Transcription, Genetic | 1995 |
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Glutamate; Time Factors | 1995 |
AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calbindins; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Embryo, Mammalian; Evoked Potentials; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein G; Time Factors | 1995 |
Structure-activity relationships in a series of 3-sulfonylamino-2-(1H)-quinolones, as new AMPA/kainate and glycine antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Molecular Structure; Oocytes; Quinolones; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; RNA, Messenger; Structure-Activity Relationship; Xenopus | 1995 |
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cya
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Kainic Acid; Neurotransmitter Uptake Inhibitors; Prosencephalon; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1995 |
Regulation of spontaneous phasic firing of rat supraoptic vasopressin neurones in vivo by glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Kainic Acid; Male; N-Methylaspartate; Oxytocin; Rats; Receptors, Glutamate; Supraoptic Nucleus; Vasopressins | 1995 |
1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Memory; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1995 |
Evidence for two types of non-NMDA receptors in rat cerebellar Purkinje cells maintained in slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Electrophysiology; Kainic Acid; Kinetics; Membrane Potentials; Neurotoxins; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Developmental change of the potentiation of NMDA response by spermine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Nystatin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spermine; Ventromedial Hypothalamic Nucleus | 1995 |
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebellum; Cobalt; Concanavalin A; Excitatory Amino Acids; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Wheat Germ Agglutinins | 1995 |
Characterization of the binding of [3H]NS 257, a novel competitive AMPA receptor antagonist, to rat brain membranes and brain sections.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Cell Membrane; Cerebral Cortex; Hydrogen-Ion Concentration; Indoles; Kainic Acid; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sulfonamides; Thiocyanates; Tritium | 1995 |
AMPA elicits long-lasting, partly hypothermia-sensitive calcium responses in acutely dissociated or cultured embryonic brainstem cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Brain Stem; Calcium; Cells, Cultured; Cytosol; Hot Temperature; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Transduction; Time Factors | 1994 |
Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Radioligand Assay; Rats; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Ca2+ permeable AMPA/kainate channels permit rapid injurious Ca2+ entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Count; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Receptors, AMPA; Receptors, Kainic Acid | 1995 |
Effects of nitric oxide availability on responses of spinal wide dynamic range neurons to excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Penicillamine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; S-Nitroso-N-Acetylpenicillamine; Spinal Canal | 1995 |
Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Electrophysiology; Kainic Acid; Neurites; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1995 |
Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcium Channels; Dendrites; Diuretics; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Kinetics; Magnesium; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Chloride Symporter Inhibitors | 1995 |
Subcellular localization and molecular pharmacology of distinct populations of [3H]-AMPA binding sites in rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Blotting, Western; Cell Fractionation; Glutamic Acid; Hippocampus; In Vitro Techniques; Isotope Labeling; Kainic Acid; Microscopy, Electron; Microsomes; Neuronal Plasticity; Protein Processing, Post-Translational; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Synaptosomes; Tritium | 1995 |
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant act
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Computer Graphics; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Mice; Models, Molecular; Molecular Structure; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Structure-Activity Relationship | 1995 |
Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Evoked Potentials; Hippocampus; Kainic Acid; Kinetics; Neurons; Patch-Clamp Techniques; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spermidine; Spermine; Time Factors | 1995 |
AMPA (amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors in human brain tissues.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain; Female; Fetus; Humans; In Vitro Techniques; Kainic Acid; Kinetics; Ligands; Oocytes; Receptors, AMPA; Receptors, Kainic Acid; RNA; Xenopus laevis | 1995 |
Acute and late neurotoxicity in the rat spinal cord in vivo induced by glutamate receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Injections; Kainic Acid; Male; Rats; Rats, Wistar; Spinal Cord Diseases; Subarachnoid Space; Survival Analysis | 1995 |
Phospholipase A2 modulates different subtypes of excitatory amino acid receptors: autoradiographic evidence.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1993 |
AMPA receptor activation potentiates zinc neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Drug Synergism; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Mice; Nervous System Diseases; Potassium; Receptors, AMPA; Receptors, Glutamate; Zinc | 1993 |
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Electric Conductivity; Excitatory Amino Acid Antagonists; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Synapses | 1993 |
Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Glutamates; Glutamic Acid; Ibotenic Acid; In Situ Hybridization; Kainic Acid; Neural Pathways; Phencyclidine; Rats; Receptors, Glutamate; RNA, Messenger; Spinal Cord; Substantia Gelatinosa | 1993 |
Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cerebral Cortex; Diuretics; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1993 |
NBQX inhibits AMPA-induced locomotion after injection into the nucleus accumbens.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Injections; Kainic Acid; Motor Activity; Nucleus Accumbens; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
N-methyl-D-aspartate- and non-N-methyl-D-aspartate-evoked adenosine release from rat cortical slices: distinct purinergic sources and mechanisms of release.
Topics: 5'-Nucleotidase; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Calcium; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nucleosides; Purines; Rats | 1993 |
Cyclothiazide treatment unmasks AMPA excitotoxicity in rat primary hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Drug Synergism; Hippocampus; Ibotenic Acid; Kainic Acid; Neurotoxins; Rats | 1993 |
Dipsogenic effects of excitatory amino acid agonists in pigeons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Columbidae; Drinking; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1993 |
Binding of [3H]MK-801, NMDA-displaceable [3H]glutamate, [3H]glycine, [3H]spermidine, [3H]kainate and [3H]AMPA to regionally discrete brain membranes of the gerbil: a biochemical study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cell Membrane; Dizocilpine Maleate; Female; Gerbillinae; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Receptors, Glutamate; Spermidine; Thiocyanates; Tissue Distribution | 1993 |
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Glycine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Glutamate; Spinal Cord; Thalamus | 1993 |
N-methyl-D-aspartate induces regular firing patterns in the cat lateral habenula in vivo.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Ibotenic Acid; Iontophoresis; Kainic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Stereotaxic Techniques; Thalamus | 1993 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Calcium permeability of non-N-methyl-D-aspartate receptor channels in immature cerebellar Purkinje cells: studies using fura-2 microfluorometry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane Permeability; Cobalt; Cytophotometry; Fluorescent Dyes; Fura-2; Gallopamil; Ibotenic Acid; Kainic Acid; Manganese; Purkinje Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium | 1993 |
Enflurane inhibits NMDA, AMPA, and kainate-induced currents in Xenopus oocytes expressing mouse and human brain mRNA.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Enflurane; Female; Humans; Ibotenic Acid; Ion Channels; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Oocytes; Receptors, Glutamate; RNA, Messenger; Species Specificity; Xenopus laevis | 1993 |
Single channel recordings of reconstituted AMPA receptors reveal low and high conductance states.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Electric Conductivity; Ibotenic Acid; Ion Channels; Kainic Acid; Lipid Bilayers; Prosencephalon; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Regression Analysis | 1993 |
Neurotransmitter receptors and voltage-dependent Ca2+ channels encoded by mRNA from the adult corpus callosum.
Topics: Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antisense Elements (Genetics); Aspartic Acid; Astrocytes; Biomarkers; Calcium Channels; Cattle; Corpus Callosum; Female; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; In Situ Hybridization; Kainic Acid; Male; Membrane Potentials; Middle Aged; Oocytes; Quisqualic Acid; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; RNA Probes; RNA, Messenger; Xenopus | 1993 |
Glutamate stimulates [3H]phorbol 12,13-dibutyrate binding in cultured Bergmann glia cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Membrane; Cells, Cultured; Cerebellum; Chick Embryo; Cytosol; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Neuroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Purkinje Cells | 1993 |
Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oocytes; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; RNA; Xenopus | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Electrophysiological evidence for the existence of NMDA and non-NMDA receptors on rat ventral tegmental dopamine neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 1993 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Cloning, Molecular; Dizocilpine Maleate; DNA; Female; Frontal Lobe; Gene Library; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Xenopus laevis | 1993 |
Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: an extracellular in vitro study.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dopamine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1993 |
Medium-dependent dissociation of cytotoxic and GABA-releasing effects of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and kainate in rat cortical cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Induction of astrocyte glutamine synthetase activity by the Lathyrus toxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (beta-L-ODAP).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Glutamate-Ammonia Ligase; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1993 |
Glutamate receptor-induced cyclic GMP formation in primary cultures of mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Carbachol; Cells, Cultured; Cyclic GMP; Fetus; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Mesencephalon; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, Glutamate | 1993 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Antibodies; Biomarkers; Epitopes; Humans; Ibotenic Acid; Immunohistochemistry; Kainic Acid; Macaca fascicularis; Macromolecular Substances; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzothiadiazines; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Neurons; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Reconstitution of glutamate receptor proteins purified from Xenopus central nervous system into artificial bilayers.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chromatography, Affinity; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Lipid Bilayers; N-Methylaspartate; Receptors, Glutamate; Xenopus | 1993 |
NMDA receptors mediate neuronal burst firing in rat somatosensory cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 1993 |
Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Eating; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electrophysiology; Energy Metabolism; Evoked Potentials; Glucose; Hippocampus; Hypoxia, Brain; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Identification of glutamate receptor subtypes mediating inputs to bipolar cells and ganglion cells in the tiger salamander retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ambystoma; Aminobutyrates; Animals; Glutamates; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Photic Stimulation; Piperazines; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Synapses | 1993 |
AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1993 |
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis | 1993 |
Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glucagon; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Islets of Langerhans; Kainic Acid; Male; Pancreas; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Non-NMDA receptors in the rostral ventrolateral medulla mediate somatosympathetic pressor responses.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Blood Pressure; Electric Stimulation; Female; Histocytochemistry; Ibotenic Acid; Kainic Acid; Medulla Oblongata; Neurons, Afferent; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Sympathetic Nervous System; Vagotomy | 1993 |
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Ganglia, Spinal; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neurons; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ketamine; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1993 |
Two distinct types of AMPA responses in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Hippocampus; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Membrane Potentials; Neurons; Pyrrolidinones; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amlodipine; Animals; Barium; Calcium Channels; Cells, Cultured; Cerebral Cortex; Dextromethorphan; Electrophysiology; Female; Kainic Acid; N-Methylaspartate; Neurons; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1993 |
Gamma-D-glutamylaminomethyl sulfonic acid (GAMS) distinguishes kainic acid- from AMPA-induced responses in Xenopus oocytes expressing chick brain glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Chick Embryo; Electrophysiology; Glutamine; Kainic Acid; Kinetics; Oocytes; Quinoxalines; Receptors, Glutamate; RNA, Messenger; Xenopus | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
A ligand binding study of the interactions of guanine nucleotides with non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Guanine Nucleotides; Guanosine Triphosphate; Kainic Acid; Kinetics; Ligands; Male; Rats; Receptors, AMPA; Receptors, Kainic Acid | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Modulation of transmission gain by protons at the photoreceptor output synapse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ambystoma; Aminobutyrates; Animals; Calcium Channels; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Light; Membrane Potentials; Photoreceptor Cells; Protons; Quisqualic Acid; Receptors, Glutamate; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Synapses; Synaptic Transmission | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
AMPA receptors shape Ca2+ responses in cortical oligodendrocyte progenitors and CG-4 cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcium; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Oligodendroglia; Quinoxalines; Receptors, AMPA; Time Factors | 1995 |
Stimulation of serotonin release in the rat brain cortex by activation of ionotropic glutamate receptors and its modulation via alpha 2-heteroreceptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Glutamate; Serotonin | 1995 |
[Possible role of the AMPA/KA receptors in cultured Müller cells].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Kainic Acid; Neuroglia; Rabbits; Receptors, Glutamate; Retina | 1995 |
An ex vivo rat retinal preparation for excitotoxicity studies.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Rats; Rats, Sprague-Dawley; Retina | 1995 |
Preferential block of desensitizing AMPA receptor in hippocampal neurons by gamma-D-glutamylaminomethylsulfonic acid.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamine; Hippocampus; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Neurons; Rats; Rats, Wistar; Receptors, AMPA | 1995 |
Fractional calcium current through neuronal AMPA-receptor channels with a low calcium permeability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cerebellum; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Permeability; Potassium; Purkinje Cells; Rats; Receptors, AMPA | 1996 |
Excitatory amino acid-induced currents in rat septal cholinergic neurons in culture.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cholinergic Fibers; Excitatory Amino Acids; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Septal Nuclei; Zinc | 1995 |
Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Culture Techniques; Ethanol; Female; Hippocampus; Kainic Acid; Membrane Potentials; Neural Inhibition; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Synaptic Transmission | 1995 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Kainic Acid; Mice; Molecular Structure; N-Methylaspartate; Neuroprotective Agents; Organophosphonates; Quinolones; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus | 1996 |
Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Cyclopentanes; GABA Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microscopy, Video; Motor Activity; N-Methylaspartate; Neostriatum; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reference Values | 1996 |
The effects of (-)- and (+)-beta-cyclazocine on NMDA-evoked responses and NMDA-mediated cell damage in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cyclazocine; Kainic Acid; Microchemistry; N-Methylaspartate; Neuroprotective Agents; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Spectrometry, Fluorescence; Stereoisomerism | 1995 |
Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Gland; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Electrophysiology; Gene Expression; Glutamic Acid; Humans; Kainic Acid; Ligands; Molecular Sequence Data; Rats; Receptors, Glutamate; Sequence Homology, Amino Acid; Species Specificity; Transfection | 1995 |
Effects of repeated cold stress on aversive responses produced by intrathecal excitatory amino acids in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cold Temperature; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Stress, Psychological | 1995 |
In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat.
Topics: Adolescent; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cricetinae; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Humans; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Potassium; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoquinolines; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
Characterization of excitatory amino acid modulation of dopamine release in the prefrontal cortex of conscious rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Consciousness; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1996 |
Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Calcium Radioisotopes; Cycloleucine; Dithionitrobenzoic Acid; Dithiothreitol; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Humans; Kainic Acid; L Cells; Ligands; Mice; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Sulfhydryl Reagents | 1996 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Median Eminence; Molecular Sequence Data; N-Methylaspartate; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Excitatory amino acid-induced neuronal cell death in rat cerebellar granule cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Septal and hippocampal glutamate receptors modulate the output of acetylcholine in hippocampus: a microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Septal Nuclei | 1996 |
Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex; Isoquinolines; Kainic Acid; Kinetics; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Radioligand Assay; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Tritium | 1996 |
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex; Electroshock; Isoquinolines; Kainic Acid; Mice; Models, Molecular; Molecular Structure; Pipecolic Acids; Rats; Receptors, AMPA; Seizures; Stereoisomerism; Structure-Activity Relationship | 1996 |
Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Receptors, Amino Acid; Retina; Salamandridae | 1995 |
Development of responses to excitatory and inhibitory amino acids in spiking cells during retinal regeneration in the adult newt.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Receptors, Amino Acid; Regeneration; Retina; Salamandridae; Strychnine | 1995 |
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Glycine; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1996 |
Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hindlimb; Kainic Acid; Logistic Models; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Antagonism of glutamate receptors by a chromatographic fraction from the exudate of the sea anemone Phyllactis flosculifera.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ambystoma; Animals; Chemical Fractionation; Chromatography, Gel; Cnidarian Venoms; Cochlea; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; Nerve Fibers; Neurons, Afferent; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Sea Anemones; Snails | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: modulation by arachidonic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Benzofurans; Calcium Chloride; Cells, Cultured; Chick Embryo; Ethers, Cyclic; Excitatory Amino Acid Agonists; Fluorescent Dyes; Glutamic Acid; Indoles; Kainic Acid; Kinetics; N-Methylaspartate; Receptors, Glutamate; Retina; Sodium; Spectrometry, Fluorescence | 1996 |
Differential cellular response after glutamate analog hippocampal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biomarkers; Brain; Brain Injuries; Cerebral Cortex; Cerebral Ventricles; Corpus Callosum; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microglia; Neurons; Rats; Rats, Wistar | 1996 |
Cobalt-permeable non-NMDA receptors in developing chick brainstem auditory nuclei.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Pathways; Benzodiazepines; Brain Stem; Cell Membrane Permeability; Chick Embryo; Cobalt; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Neurons; Receptors, N-Methyl-D-Aspartate | 1995 |
Lead-induced blockage of kainate-sensitive receptor channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ion Channels; Kainic Acid; Lead; Membrane Potentials; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1995 |
Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Calcium; Cells, Cultured; Dicarboxylic Acids; Eye Proteins; Intermediate Filament Proteins; Ion Channels; Kainic Acid; Membrane Glycoproteins; Mice; Motor Neurons; Nerve Tissue Proteins; Neuropeptides; Neurotransmitter Uptake Inhibitors; Peripherins; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Spinal Cord | 1996 |
Ca(2+)-permeable AMPA/kainate and NMDA channels: high rate of Ca2+ influx underlies potent induction of injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Intracellular Membranes; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Osmolar Concentration; Permeability; Time Factors | 1996 |
[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Excitatory Amino Acid Agonists; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Retina; Stimulation, Chemical | 1996 |
Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Weight; Circadian Rhythm; Eating; Excitatory Amino Acid Antagonists; Food Deprivation; Glutamic Acid; Hypothalamic Area, Lateral; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
Opposite effects of TGF-beta 1 on rapidly- and slowly-triggered excitotoxic injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Purkinje Cells; Rats; Time Factors; Transforming Growth Factor beta | 1996 |
Interaction between striatal excitatory amino acid and gamma-aminobutyric acid (GABA) receptors in the turning behaviour of rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Caudate Nucleus; Data Interpretation, Statistical; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Male; N-Methylaspartate; Neostriatum; Picrotoxin; Putamen; Rats; Rats, Wistar; Receptors, GABA; Receptors, Glutamate | 1995 |
A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and ionotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bicuculline; Cells, Cultured; Ciprofloxacin; Drug Interactions; Hippocampus; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 1995 |
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoimidazole Carboxamide; Animals; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Ribonucleosides | 1996 |
Distribution of neurones expressing inwardly rectifying and Ca(2+)-permeable AMPA receptors in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Synaptic Transmission | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Domoic acid induces the release of glutamate in the rat hippocampal CA3 subregion.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Synaptosomes | 1996 |
Ultrastructure of excitotoxic neuronal death in murine cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aurintricarboxylic Acid; Bisbenzimidazole; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; Dizocilpine Maleate; DNA Damage; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microscopy, Electron; Mitochondria; Neuroglia; Neurons; Neurotoxins; Propidium; Protein Synthesis Inhibitors; Vacuoles | 1995 |
Membrane currents evoked by ionotropic glutamate receptor agonists in rod bipolar cells in the rat retinal slice preparation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Membrane Potentials; Microscopy, Video; Rats; Retinal Rod Photoreceptor Cells; Subcellular Fractions; Synaptic Transmission | 1996 |
Different characteristics of AMPA receptor agonists acting at AMPA receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Kainic Acid; Oocytes; Patch-Clamp Techniques; Quinoxalines; Receptors, AMPA; Xenopus laevis | 1996 |
The vulnerability of spinal cord neurons to excitotoxic injury: comparison with cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cobalt; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Spinal Cord; Staining and Labeling; Time Factors | 1996 |
Selective degeneration of inhibitory interneurons in the rat spinal cord induced by intrathecal infusion of acromelic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Interneurons; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1995 |
Electrophysiological characterization of non-NMDA glutamate receptors on cultured intermediate lobe cells of the rat pituitary.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Membrane Potentials; Pituitary Gland; Quisqualic Acid; Rats; Receptors, Glutamate | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain Injuries; Cells, Cultured; Cerebral Cortex; Chromans; Deferoxamine; Drug Synergism; Excitatory Amino Acids; Hemoglobin A; Humans; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroglia; Neurons | 1996 |
Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acids; Kainic Acid; Macaca; Male; Membrane Potentials; N-Methylaspartate; Thalamus | 1996 |
Purification and biochemical characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate-sensitive L-glutamate receptors of pig brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Gel, Two-Dimensional; Glutamic Acid; Kainic Acid; Molecular Weight; Octoxynol; Polyethylene Glycols; Potassium Chloride; Rats; Receptors, AMPA; Receptors, Kainic Acid; Solubility; Swine; Synaptic Membranes | 1996 |
Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Drug; Kainic Acid; Male; Oocytes; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 1996 |
Possible roles of AMPA/KA receptor in cultured Müller cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Kainic Acid; L-Lactate Dehydrogenase; Neuroglia; Neurons; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Kainic Acid; Male; Maze Learning; N-Methylaspartate; Organ Specificity; Prosencephalon; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Tritium | 1996 |
Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, Tachykinin; Spinal Cord | 1996 |
Non-NMDA glutamate receptor binding in canine brain after global cerebral ischemia and reperfusion.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cardiopulmonary Resuscitation; Corpus Striatum; Dogs; Female; Glutamic Acid; Heart Arrest; Hippocampus; Ischemic Attack, Transient; Kainic Acid; Kinetics; Neurons; Organ Specificity; Parietal Lobe; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Reperfusion; Temporal Lobe; Time Factors; Tritium | 1996 |
Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor agonists and antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Kainic Acid; Norepinephrine; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid | 1996 |
Kainate and AMPA receptors in the rat brain in thioacetamide-induced hepatic encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Corpus Striatum; Glutamic Acid; Hepatic Encephalopathy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1996 |
Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Isotopes; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Deferoxamine; Deuterium; Dizocilpine Maleate; Fetus; Gas Chromatography-Mass Spectrometry; Glucose; Hydrogen Peroxide; Iron; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Pentose Phosphate Pathway; Putamen; Quinoxalines; Rats | 1996 |
Ca2+ signaling pathways linked to glutamate receptor activation in the somatic and dendritic regions of cultured cerebellar purkinje neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Dendrites; Kainic Acid; Purkinje Cells; Rats; Receptors, Glutamate | 1996 |
Glutamate as a putative neurotransmitter in the mollusc, Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Diphosphate; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Quisqualic Acid; Synapses; Thionucleotides | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
Pathophysiology of oligodendroglial excitotoxicity.
Topics: Acetylcysteine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aurintricarboxylic Acid; Benzothiadiazines; Biological Transport; Calcium; Cell Line; Cell Membrane; DNA Fragmentation; Endodeoxyribonucleases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nerve Tissue Proteins; Oligodendroglia; Rats; Receptors, AMPA; RNA, Messenger | 1996 |
Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kinetics; Quinoxalines; Rats; Rats, Wistar; Tetrodotoxin; Tritium | 1996 |
Felbamate decreases synaptic transmission in the CA1 region of rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Potentials; Felbamate; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Death; Cells, Cultured; Complement C5; Electrophysiology; Hippocampus; Interleukin-6; Kainic Acid; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nerve Degeneration; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tumor Necrosis Factor-alpha | 1996 |
mu-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synapses; Synaptic Transmission | 1997 |
Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Cobalt; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord Injuries | 1997 |
NMDA and kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Potassium Chloride; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 1996 |
Differential effects of excitatory amino acids on mesencephalic neurons expressing either calretinin or tyrosine hydroxylase in primary cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calbindin 2; Cell Survival; Cells, Cultured; Excitatory Amino Acids; Kainic Acid; Mesencephalon; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Phenotype; Rats; S100 Calcium Binding Protein G; Tyrosine 3-Monooxygenase | 1996 |
Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Isoquinolines; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Tetrazoles | 1996 |
Release of [3H]dopamine from striatal and cerebral cortical slices from rats with thioacetamide-induced hepatic encephalopathy: different responses to stimulation by potassium ions and agonists of ionotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Hepatic Encephalopathy; Kainic Acid; Male; N-Methylaspartate; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Thioacetamide; Tritium | 1997 |
An electrophysiological study of neurons in the horizontal limb of the diagonal band of Broca.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1997 |
Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar | 1997 |
Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1997 |
Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport, Active; Diffusion; Electric Stimulation; Evoked Potentials; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Temperature | 1997 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Activation of AMPA and kainate glutamate receptors impairs the viability of oligodendrocytes in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Oligodendroglia; Optic Nerve; Protein Conformation; Rats; Receptors, AMPA; Receptors, Kainic Acid | 1996 |
Intracellular Ca2+, Na+ and H+ transients evoked by kainate in the leech giant glial cells in situ.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electric Conductivity; Fura-2; Gallopamil; Ganglia, Invertebrate; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Kinetics; Leeches; Membrane Potentials; Microelectrodes; Neuroglia; Nickel; Patch-Clamp Techniques; Receptors, Glutamate; Sodium | 1997 |
Unilateral eyeball enucleation differentially alters AMPA-, NMDA- and kainate glutamate receptor binding in the newborn rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Brain; Eye Enucleation; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Visual Cortex | 1996 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
Glutamate-induced hyperpolarization in mouse cerebellar Purkinje cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Purkinje Cells; Quisqualic Acid | 1993 |
Glutamate receptor agonists evoked Ca(2+)-dependent and Ca(2+)-independent release of [3H]D-aspartate from cultured chick retina cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Chickens; Excitatory Amino Acid Agonists; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Potassium Chloride; Receptors, Glutamate; Retina; Tritium | 1996 |
Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Apoptosis; Carbon; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electron Spin Resonance Spectroscopy; Excitatory Amino Acid Agonists; Free Radical Scavengers; Fullerenes; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Patch-Clamp Techniques; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1996 |
Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dendrites; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Kinetics; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate | 1997 |
Muscarinic reduction of GABAergic synaptic potentials results in disinhibition of the AMPA/kainate-mediated EPSP in auditory cortex.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Cortex; Electrophysiology; gamma-Aminobutyric Acid; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1997 |
Role of histidyl residues in the binding of ligands to the porcine N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cerebral Cortex; Diethyl Pyrocarbonate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Histidine; Ionophores; Kainic Acid; Ligands; N-Methylaspartate; Piperazines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swine; Synaptic Membranes; Tritium | 1997 |
Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellar Cortex; Cerebral Cortex; Cysteine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Proto-Oncogene Proteins c-fos; RNA, Messenger | 1997 |
Differential desensitization of ionotropic non-NMDA receptors having distinct neuronal location and function.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcium; Cerebral Cortex; Choline; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Norepinephrine; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Serotonin; Synaptosomes | 1997 |
Inhibition of [3H]MK-801 binding by ferrous (II) but not ferric (III) ions in a manner different from that by sodium nitroprusside (II) in rat brain synaptic membranes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chlorides; Dizocilpine Maleate; Ferric Compounds; Ferricyanides; Ferrocyanides; Ferrous Compounds; Ion Channels; Iron Chelating Agents; Kainic Acid; Male; Nitroprusside; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1997 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Binding Sites; Corpus Striatum; Dizocilpine Maleate; DNA Fragmentation; Excitatory Amino Acid Antagonists; Hydroxyl Radical; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nitric Oxide Synthase; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tyrosine | 1997 |
Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Fetus; Kainic Acid; Kinetics; Marine Toxins; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide Synthase; Okadaic Acid; Oxocins; Rats; Rats, Sprague-Dawley; Spectrin | 1997 |
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Corpus Callosum; Electrophysiology; Evoked Potentials; In Vitro Techniques; Isoxazoles; Kainic Acid; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Potentiometry; Rats; Receptors, AMPA; Receptors, Kainic Acid; Structure-Activity Relationship | 1997 |
Neuropeptide Y release from cultured hippocampal neurons: stimulation by glutamate acting at N-methyl-D-aspartate and AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antibody Specificity; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neurons; Neuropeptide Y; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: II. Alpha-AMPA and kainate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Gene Expression Regulation, Developmental; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Immunohistochemistry; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Tritium; Vibrissae | 1997 |
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Corpus Callosum; Dipeptides; Electrophysiology; Excitatory Amino Acid Antagonists; Kainic Acid; Models, Chemical; N-Methylaspartate; Piperazines; Rats; Receptors, AMPA; Stereoisomerism | 1997 |
Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Calcium; Cells, Cultured; Cerebellum; Concanavalin A; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Intracellular Membranes; Isoquinolines; Kainic Acid; Neurons; Rats; Receptors, Kainic Acid; Tetrazoles | 1997 |
Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Corpus Callosum; Crystallography, X-Ray; Electrophysiology; Excitatory Amino Acid Antagonists; Indicators and Reagents; Isoxazoles; Kainic Acid; Models, Molecular; Molecular Conformation; Molecular Structure; Radioligand Assay; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Tritium | 1997 |
Inwardly rectifying and Ca2+-permeable AMPA-type glutamate receptor channels in rat neocortical neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Calcium; Calcium Channels; Electric Conductivity; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Membrane Potentials; Nerve Fibers; Neurons; Occipital Lobe; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, GABA-A; Spermine; Synapses | 1997 |
Effect of excitatory amino acids on rat hypothalamic somatostatin secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar; Receptors, Glutamate; Somatostatin | 1997 |
5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Kainic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Quinoxalines; Rats | 1997 |
Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Culture Media, Conditioned; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1997 |
Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Glucose; Hippocampus; Ischemic Preconditioning; Kainic Acid; Nerve Tissue Proteins; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Spider Venoms | 1997 |
Measurement of intracellular free zinc in living cortical neurons: routes of entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Ionophores; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neocortex; Neurons; Nimodipine; Quinoxalines; Sodium-Calcium Exchanger; Zinc | 1997 |
Age-related functional changes of the glutamate receptor channels in rat Meynert neurones.
Topics: Acetylcholinesterase; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electric Stimulation; Electrophysiology; Histocytochemistry; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Innominata | 1997 |
Acute ethanol alters calcium signals elicited by glutamate receptor agonists and K+ depolarization in cultured cerebellar Purkinje neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellar Cortex; Cycloleucine; Embryo, Mammalian; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Membrane Potentials; Potassium; Purkinje Cells; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Resorcinols | 1997 |
Glutamate-stimulated production of inositol phosphates is mediated by Ca2+ influx in oligodendrocyte progenitors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kainic Acid; Oligodendroglia; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Stem Cells | 1997 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Dioxide; Cold Temperature; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Goats; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics | 1998 |
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kinetics; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Rats; Spinal Cord | 1997 |
Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Glutamic Acid; Hippocampus; Kainic Acid; Male; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Rats, Wistar; Receptors, Glutamate; Spider Venoms; Synaptosomes | 1998 |
AMPA receptors are coupled to the nitric oxide/cyclic GMP pathway in cerebellar astroglial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Cobalt; Cyclic GMP; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1997 |
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Rats; Time Factors | 1998 |
Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Glutamate; Taurine | 1997 |
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Brain Ischemia; Cell Death; Cells, Cultured; Glutamic Acid; Growth Substances; Hypoxia; Kainic Acid; Male; Mice; Microinjections; Oligodendroglia; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Signal Transduction; Time Factors | 1998 |
Kainate-stimulated Zn2+ uptake labels cortical neurons with Ca2+-permeable AMPA/kainate channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chemical Precipitation; Cobalt; Ion Channels; Kainic Acid; Membrane Potentials; Mice; Nerve Degeneration; Neurons; Permeability; Zinc | 1998 |
The AMPA-receptor antagonist YM90K reduces AMPA receptor-mediated excitotoxicity in rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Diuretics; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1998 |
Synapse-specific accumulation of lithium in intracellular microdomains: a model for uncoupling coincidence detection in the brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Computer Simulation; Electric Conductivity; Electrophysiology; Extracellular Space; Female; Intracellular Membranes; Kainic Acid; Lithium; Models, Neurological; N-Methylaspartate; Neural Conduction; Neurons; Oocytes; Permeability; Substrate Specificity; Synapses; Xenopus | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems | 1998 |
The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electric Conductivity; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 1998 |
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Corpus Striatum; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Huntington Disease; Interneurons; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Characterization of cyclothiazide-enhanced kainate excitotoxicity in rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Mammalian; Hippocampus; Kainic Acid; Rats; Rats, Wistar; Receptors, AMPA | 1998 |
Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cadmium; Cerebellum; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mice; Neural Inhibition; Neuromuscular Depolarizing Agents; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Synaptic Transmission; Tetrodotoxin | 1998 |
Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Macaca fascicularis; Male; N-Methylaspartate; Thalamic Nuclei | 1998 |
Functional AMPA/kainate receptors in human embryonic and foetal central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Brain Stem; Cobalt; Embryo, Mammalian; Fetus; Gestational Age; Humans; Kainic Acid; Neurotoxins; Receptors, AMPA; Receptors, Kainic Acid; Rhombencephalon; Spinal Cord | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antihypertensive Agents; Benzothiadiazines; Calcium; Calcium Channel Blockers; Cell Death; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Homeostasis; Humans; Kainic Acid; Membrane Potentials; Neurons; Neurotoxins; Nimodipine; Potassium; Receptors, AMPA; Sodium; Sodium-Calcium Exchanger; Spider Venoms | 1998 |
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium | 1998 |
Kainate receptor modulation of GABA release involves a metabotropic function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carcinogens; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Second Messenger Systems; Sodium; Staurosporine; Sulfonamides; Tetraethylammonium; Tetrodotoxin; Thionucleotides; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Characterization of temperature rise of the brain and the rectum following intracerebroventricular administration of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indomethacin; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rectum | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Physiological and molecular properties of AMPA/Kainate receptors expressed by striatal medium spiny neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corpus Striatum; Cytosol; Excitatory Amino Acid Agonists; Kainic Acid; Neurons; Osmolar Concentration; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Kainic Acid; RNA, Messenger; Transcription, Genetic | 1998 |
Investigations of non-NMDA receptor-induced toxicity in serum-free antioxidant-rich primary cultures of murine cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cytoplasmic Granules; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1998 |
Extracellular acidity potentiates AMPA receptor-mediated cortical neuronal death.
Topics: Acids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anaerobiosis; Animals; Calcium; Cell Death; Cerebral Cortex; Excitatory Amino Acid Agonists; Extracellular Space; Glucose; Hydrogen-Ion Concentration; Intracellular Membranes; Kainic Acid; Mice; Neurons; Receptors, AMPA | 1998 |
Desensitization of AMPA receptors on horizontal cells isolated from crucian carp retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cells, Cultured; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Goldfish; Kainic Acid; Patch-Clamp Techniques; Receptors, AMPA; Retina | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Selective modulation of GABAA receptors by aluminum.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aluminum; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, Glutamate; Smell | 1998 |
Differential roles for NMDA and non-NMDA receptor subtypes in baroreceptor afferent integration in the nucleus of the solitary tract of the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Phenylephrine; Pressoreceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Synapses; Vasoconstrictor Agents | 1998 |
Activity-dependent modulation of glutamate receptors by polyamines.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cells, Cultured; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channel Gating; Ions; Kainic Acid; Kidney; Kinetics; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Phenols; Polyamines; Receptors, AMPA; Receptors, Kainic Acid; Spermidine; Spermine | 1998 |
Septotemporal distribution of [3H]MK-801, [3H]AMPA and [3H]Kainate binding sites in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
Glutamatergic and GABAergic agonists increase [Ca2+]i in avian cochlear nucleus neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; GABA Agonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Stimulation, Chemical | 1998 |
NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Dizocilpine Maleate; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Presynaptic Terminals; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium Radioisotopes; Cells, Cultured; Chickens; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Neuromuscular Depolarizing Agents; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1998 |
Studies of the antagonist actions of (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl] propionic acid (ATPO) on non-NMDA receptors in cultured rat neurones.
Topics: Adrenal Cortex Hormones; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cells, Cultured; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Isoxazoles; Kainic Acid; Neurons; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1998 |
Activation of NMDA and non-NMDA receptors in the caudal ventrolateral medulla dilates the airways.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine Derivatives; Autonomic Nervous System; Bronchoconstriction; Cholinergic Fibers; Dogs; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Kainic Acid; Lung; Male; Medulla Oblongata; Muscle, Smooth; N-Methylaspartate; Parasympatholytics; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1998 |
Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cricetinae; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Gene Expression; Genes, fos; Glutamic Acid; Kainic Acid; Male; Mesocricetus; N-Methylaspartate; Phosphorylation; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1999 |
Excitotoxic death of a subset of embryonic rat motor neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Culture Techniques; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Chromans; Cysteine Proteinase Inhibitors; Dizocilpine Maleate; Dopamine Agonists; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Free Radicals; Hypoglycemic Agents; Insulin; Kainic Acid; Lipid Peroxidation; Mice; Microscopy, Electron; Mitochondrial Swelling; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Oligopeptides; Oxidative Stress; Pregnancy; Zinc | 1999 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Activation of excitatory amino acid receptors in bovine dental pulp evokes the release of iCGRP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Cattle; Dental Pulp; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Radioimmunoassay; Receptors, Glutamate; Statistics, Nonparametric | 1999 |
Actions of excitatory amino acids on mesencephalic trigeminal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acids; Kainic Acid; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Trigeminal Nuclei | 1998 |
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cycloleucine; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Male; Neostriatum; Nerve Growth Factors; Neuroprotective Agents; Neurotrophin 3; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chorda Tympani Nerve; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Inosine Monophosphate; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Potassium; Propionates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Taste | 1999 |
Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Animals, Newborn; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; GTP-Binding Proteins; Indoles; Kainic Acid; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligodendroglia; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Transduction; Stem Cells; Tritium; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1999 |
Ionotropic glutamate receptors in isolated horizontal cells of the rabbit retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1999 |
Spatiotemporal patterning of glutamate receptors in developing ferret striate cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ferrets; Kainic Acid; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium; Visual Cortex | 1999 |
AMPA-preferring receptors with high Ca2+ permeability mediate dendritic plasticity of retinal horizontal cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Carps; Dark Adaptation; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Membrane Potentials; Microscopy, Electron; Neuronal Plasticity; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1999 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Kainic Acid; Male; Mossy Fibers, Hippocampal; N-Methylaspartate; Organ Culture Techniques; Parasympathomimetics; Patch-Clamp Techniques; Perforant Pathway; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Status Epilepticus; Synapses | 1999 |
Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Signaling; Cell Line, Transformed; Cerebral Cortex; Chromosomes, Human, Pair 16; Fetus; Glutamic Acid; Humans; Intracellular Membranes; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Osmolar Concentration; Receptors, Glutamate; Reference Values; Trisomy | 1999 |
Some interactions of L-DOPA and its related compounds with glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kainic Acid; Levodopa; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Xenopus laevis | 1999 |
Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Artifacts; Biological Transport; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Male; Models, Biological; Models, Molecular; N-Methylaspartate; Neurons; Rabbits; Retina; Retinal Ganglion Cells | 1999 |
Kainate activation of horizontal, bipolar, amacrine, and ganglion cells in the rabbit retina.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Female; Immunohistochemistry; Kainic Acid; Male; Models, Biological; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells | 1999 |
Beta-alanine release from the adult and developing hippocampus is enhanced by ionotropic glutamate receptor agonists and cell-damaging conditions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Cell Hypoxia; Drug Synergism; Excitatory Amino Acid Agonists; Female; Free Radicals; Glucose; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Nitrogen; Oxidative Stress; Sodium | 1999 |
Guanine nucleotides, including GMP, antagonize kainate responses in Xenopus oocytes injected with chick cerebellar membranes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Cell Membrane; Cerebellum; Chickens; Electric Conductivity; Excitatory Amino Acid Agonists; Female; Guanine Nucleotides; Guanosine Monophosphate; Injections; Ion Channels; Kainic Acid; Membranes; Oocytes; Xenopus laevis | 1999 |
Stereoselective neuroprotection by novel 2,3-benzodiazepine non-competitive AMPA antagonist against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cell Survival; Cells, Cultured; Excitatory Amino Acid Antagonists; Fetus; Flumazenil; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
A high-affinity presynaptic kainate-type glutamate receptor facilitates glutamate exocytosis from cerebral cortex nerve terminals (synaptosomes).
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; Kainic Acid; Male; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Synaptosomes | 1999 |
Reduced Mg2+ blockade of synaptically activated N-methyl-D-aspartate receptor-channels in CA1 pyramidal neurons in kainic acid-lesioned rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Lidocaine; Magnesium; Male; Models, Neurological; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reference Values; Synaptic Transmission | 1999 |
Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area.
Topics: Action Potentials; Aldosterone; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corticosterone; Dopamine; Drug Synergism; Electrophysiology; Excitatory Amino Acids; In Vitro Techniques; Kainic Acid; Male; Mifepristone; N-Methylaspartate; Neurons; Rats; Receptors, Glucocorticoid; Tegmentum Mesencephali; Time Factors | 1999 |
Different nitric oxide synthase inhibitors cause rapid and differential alterations in the ligand-binding capacity of transmitter receptors in the rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Cerebral Cortex; Dizocilpine Maleate; Kainic Acid; Male; Muscimol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Oxotremorine; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tritium | 1999 |
AMPA receptor protein expression and function in astrocytes cultured from hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Blotting, Northern; Cells, Cultured; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1999 |
Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Domperidone; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Hormone; Kainic Acid; Luteinizing Hormone; Male; Ovariectomy; Pituitary Gland, Anterior; Prolactin; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine; Sexual Maturation | 1999 |
Inhibition of excitatory neurotransmitter-nitric oxide signaling pathway by inhalational anesthetics.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Arginine; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Halothane; Isoflurane; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Signal Transduction | 1999 |
Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine Vasopressin; Calcium; Cell Culture Techniques; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Fetus; Kainic Acid; N-Methylaspartate; Neurons; Neurophysins; Neurosecretory Systems; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; GluK2 Kainate Receptor; Glutamates; Hippocampus; Humans; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Tetrazoles | 1999 |
Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Intracranial Thrombosis; Kainic Acid; Light; Male; Radiation Injuries, Experimental; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors; Up-Regulation | 1999 |
Opposite modulation of capsaicin-evoked substance P release by glutamate receptors.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Nociceptors; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Excitotoxic effects of non-NMDA receptor agonists in organotypic corticostriatal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kainic Acid; L-Lactate Dehydrogenase; Neocortex; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar | 1999 |
Regulation of substantia nigra pars reticulata neuronal activity by excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra | 1999 |
Premotor input to hypoglossal motoneurons from Kölliker-Fuse neurons in decerebrate cats.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Electric Stimulation; Electrophysiology; Excitatory Amino Acids; Histocytochemistry; Hypoglossal Nerve; Kainic Acid; Laryngeal Nerves; Microinjections; Motor Neurons; N-Methylaspartate; Phrenic Nerve; Receptors, Glutamate | 1999 |
Calcium handling proteins in isolated spinal motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cells, Cultured; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate Receptors; Kainic Acid; Motor Neurons; Nerve Tissue Proteins; Protein Isoforms; Rats; Receptors, AMPA; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Spinal Cord | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Binding Sites; Dizocilpine Maleate; Epilepsy; Female; Humans; Kainic Acid; Male; Muscimol; Neocortex; Receptors, AMPA; Receptors, GABA-A; Receptors, Glutamate; Tissue Distribution | 1999 |
AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Calcium; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Gene Expression; Kainic Acid; Motor Neurons; Nerve Degeneration; Neurotoxins; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2000 |
GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Gene Expression; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Ion Channel Gating; Isoxazoles; Kainic Acid; Neurons; Propionates; Protein Structure, Tertiary; Rats; Receptors, Kainic Acid; RNA, Messenger; Structure-Activity Relationship | 2000 |
AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Buffers; Calcium; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Fluorescent Dyes; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mitochondria; Motor Neurons; Neurotoxins; Phenanthridines; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid; Spinal Cord | 2000 |
AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Calcium; Cells, Cultured; Cerebral Cortex; Concanavalin A; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; Microglia; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; Stimulation, Chemical; Tumor Necrosis Factor-alpha | 2000 |
Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Brachyura; Cells, Cultured; Chloride Channels; Chlorides; Concanavalin A; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quisqualic Acid; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate | 2000 |
Contribution of Ca(2+)-permeable AMPA/KA receptors to glutamate-induced Ca(2+) rise in embryonic lumbar motoneurons in situ.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lumbosacral Region; Motor Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Spider Venoms; Spinal Cord | 2000 |
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 2000 |
Intracellular survival pathways against glutamate receptor agonist excitotoxicity in cultured neurons. Intracellular calcium responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Receptors, Glutamate | 1999 |
Attenuation of neuronal death by NMDA and oxygen-glucose deprivation in cortical neurons maintained in high glucose.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Fetus; Glucose; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins | 1999 |
Kainate receptors activate NF-kappaB via MAP kinase in striatal neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcimycin; Calcium; Cells, Cultured; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; Immunohistochemistry; In Vitro Techniques; Ionophores; Kainic Acid; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; NF-kappa B; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Transcription Factor RelA | 2000 |
Endogenously generated spontaneous spiking activities recorded from postnatal spiral ganglion neurons in vitro.
Topics: Action Potentials; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Mice; Neurons, Afferent; Potassium Channels; Potassium Channels, Voltage-Gated; Quinoxalines; Receptors, Glutamate; Shaw Potassium Channels; Spiral Ganglion | 2000 |
Effects of dalargin on excitation induced by L-glutamate agonists in the frog vestibular organs.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Dendrites; Electrophysiology; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Rana temporaria; Receptors, Opioid; Synapses; Vestibule, Labyrinth | 2000 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Sustained ethanol inhibition of native AMPA receptors on medial septum/diagonal band (MS/DB) neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Diagonal Band of Broca; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Septum of Brain; Up-Regulation | 2000 |
Administration of either non-NMDA receptor agonists or NMDA receptor antagonists into the substantia nigra or the globus pallidus reduces the psychostimulant effect of high helium pressure on locomotor activity in rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atmospheric Pressure; Excitatory Amino Acid Agonists; Globus Pallidus; Helium; Injections; Kainic Acid; Male; Motor Activity; Myoclonus; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1999 |
Neuroprotective effects of creatine administration against NMDA and malonate toxicity.
Topics: Administration, Oral; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corpus Striatum; Creatine; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Malonates; Mitochondria; N-Methylaspartate; Neuroprotective Agents; Niacinamide; Rats; Rats, Sprague-Dawley | 2000 |
Axonal stratification patterns and glutamate-gated conductance mechanisms in zebrafish retinal bipolar cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Axons; Chlorides; Cycloleucine; Dendrites; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Neurons; Picrotoxin; Retina; Strychnine; Zebrafish | 2000 |
Involvement of NMDA-receptor in kainate-induced neurotoxicity in cultured fetal retinal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Retina | 2000 |
Kainate receptor-mediated activation of the AP-1 transcription factor complex in cultured rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cells, Cultured; Cerebellum; Concanavalin A; Dimerization; Excitatory Amino Acid Antagonists; Isoquinolines; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tetrazoles; Transcription Factor AP-1 | 2000 |
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Topics: Adjuvants, Immunologic; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Excitatory Amino Acid Agonists; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Pain; Pertussis Toxin; Spinal Cord; Virulence Factors, Bordetella | 2000 |
Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Biological Transport; Calcium; Cell Survival; DNA Primers; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Islets of Langerhans; Kainic Acid; Protein Kinase C; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spider Venoms; Tumor Cells, Cultured | 2000 |
Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]i changes in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, AMPA | 2000 |
Water maze and radial maze learning and the density of binding sites of glutamate, GABA, and serotonin receptors in the hippocampus of inbred mouse strains.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Autoradiography; Dentate Gyrus; Dizocilpine Maleate; Escape Reaction; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Muscimol; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, Serotonin; Serotonin; Species Specificity; Tritium | 2000 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship | 2000 |
Neutral red as a hydrophobic probe for monitoring neuronal activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; Electric Stimulation; Excitatory Amino Acid Agonists; Fluorescent Dyes; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Kainic Acid; Male; Membrane Lipids; Microscopy, Fluorescence; Neurons; Neutral Red; Osmolar Concentration; Phospholipids; Purkinje Cells; Rats; Rats, Wistar; Subtraction Technique | 2000 |
Functional ionotropic glutamate receptors emerge during terminal cell division and early neuronal differentiation of rat neuroepithelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bromodeoxyuridine; Calcium; Cell Differentiation; Cells, Cultured; DNA Primers; Epithelial Cells; Epitopes; Excitatory Amino Acid Agonists; Female; Flow Cytometry; Gene Expression Regulation, Developmental; Kainic Acid; Membrane Potentials; Mitosis; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stem Cells; Telencephalon; Transcription, Genetic | 2000 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Design; Humans; Kainic Acid; Male; Mice; Molecular Structure; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Retina; Seizures; Structure-Activity Relationship | 2000 |
8-Methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones: highly in vivo potent and selective AMPA receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Imidazoles; Kainic Acid; Male; Mice; Microinjections; Molecular Structure; Oocytes; Patch-Clamp Techniques; Pyrazines; Radioligand Assay; Rats; Receptors, AMPA; RNA, Messenger; Stereoisomerism | 2000 |
Ca2+-dependent desensitization of AMPA receptors.
Topics: Adamantane; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alternative Splicing; Animals; Animals, Newborn; Antihypertensive Agents; Benzothiadiazines; Calcium; Calcium Signaling; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Kainic Acid; Neurons; Nootropic Agents; Pyrrolidinones; Rats; Receptors, AMPA | 2000 |
AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Benzodiazepines; Benzothiadiazines; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Membrane Potentials; Motor Neurons; Patch-Clamp Techniques; Posterior Horn Cells; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2000 |
Glutamate receptors of the AMPA type modulate neurotransmitter release and peristalsis in the guinea-pig isolated colon.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Guinea Pigs; In Vitro Techniques; Kainic Acid; Muscle, Smooth; Myenteric Plexus; Norepinephrine; Peristalsis; Propranolol; Receptors, AMPA; Sympathectomy; Yohimbine | 2000 |
Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Female; Kainic Acid; Magnesium Sulfate; Pregnancy; Pregnancy, Animal; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Sodium Chloride; Tissue Distribution | 2000 |
In situ Ca2+ imaging reveals neurotransmitter receptors for glutamate in taste receptor cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Dextrans; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Microscopy, Confocal; N-Methylaspartate; Neurotransmitter Agents; Organic Chemicals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Taste Buds | 2000 |
Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Blotting, Northern; Calcium; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gene Expression; Humans; Intracellular Fluid; Kainic Acid; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Receptors, Glutamate; Retinoblastoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2000 |
A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Benzothiadiazines; Biological Transport; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Kinetics; Mice; Models, Theoretical; N-Methylaspartate; Sodium; Symporters | 2000 |
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Quinoxalines; Receptors, AMPA; Structure-Activity Relationship; Zinc | 2000 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures | 2001 |
Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Gene Expression Regulation; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcription, Genetic | 2001 |
Role of non-NMDA receptors in vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Glutamates; Hypothalamo-Hypophyseal System; Kainic Acid; Kinetics; Male; N-Methylaspartate; Organ Culture Techniques; Oxytocin; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vasopressins | 2001 |
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Topics: 2,4-Dinitrophenol; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclosporine; Dibucaine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Imidazoles; Kainic Acid; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rhodamines; Spinal Cord; Superoxide Dismutase; Uncoupling Agents | 2001 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nitric Oxide; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tritium | 2001 |
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Corpus Striatum; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2001 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation, Developmental; Humans; Indoles; Kainic Acid; Piperidines; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tritium | 2001 |
Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Neurons; NG-Nitroarginine Methyl Ester; Propionates; Quisqualic Acid; Retina; Signal Transduction; Tetrodotoxin; Trifluoperazine; Verapamil | 2001 |
Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase; Lamotrigine; N-Methylaspartate; Necrosis; Neuroprotective Agents; Phenethylamines; Retina; Retinal Ganglion Cells; Triazines | 2001 |
Distribution of [3H]MK-801, [3H]AMPA and [3H]Kainate binding sites in rat hippocampal long-term slice cultures isolated from external afferents.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Glutamate; Thymidine; Tissue Distribution | 2001 |
Characterization of ionotropic glutamate receptors in human lymphocytes.
Topics: 2-Amino-5-phosphonovalerate; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies, Monoclonal; Calcium; CD3 Complex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Lymphocytes; N-Methylaspartate; Phytohemagglutinins; Quinoxalines; Receptors, Glutamate | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc | 2001 |
Suppression of presynaptic responses to adenosine by activation of NMDA receptors.
Topics: Action Potentials; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; N-Methylaspartate; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Time Factors; Triazines; Triazoles | 2001 |
Stimulatory effects of centrally injected kainate and N-methyl-D-aspartate on gastric acid secretion in anesthetized rats.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine; Brain; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2001 |
Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Chick Embryo; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Necrosis; Receptors, Glutamate; Retina | 2001 |
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar | 2001 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Communication; Cell Differentiation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuroglia; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar | 2001 |
Role of K(+) efflux in apoptosis induced by AMPA and kainate in mouse cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Enzyme Activation; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Neurons; Potassium | 2001 |
Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Size; Dendrites; Excitatory Amino Acid Agonists; Fluorescent Dyes; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Synaptic Transmission; Time Factors | 2001 |
The effect of kainic acid and AMPA on the release of taurine and GABA from the rat substantia nigra in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Kainic Acid; Male; Rats; Rats, Wistar; Substantia Nigra; Taurine | 2000 |
Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity.
Topics: Adrenergic alpha-Agonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Carbazoles; Cerebral Cortex; Clonidine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Models, Neurological; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Phenazocine; Prosencephalon; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Scopolamine | 2002 |
Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Concanavalin A; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2002 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Calcium; Calcium Channel Blockers; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Lanthanum; Neurotoxins; Nifedipine; Oligodendroglia; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid | 2002 |
Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Bicuculline; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Human Growth Hormone; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Sexual Maturation | 2002 |
Complestatin antagonizes the AMPA/kainate-induced neurotoxicity in cultured chick telencephalic neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chick Embryo; Chickens; Chlorophenols; Excitatory Amino Acid Antagonists; Kainic Acid; Neurons; Oligopeptides; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Staurosporine; Telencephalon; Time Factors | 2002 |
Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Differentiation; Chick Embryo; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; GluK2 Kainate Receptor; Glutamic Acid; Immunohistochemistry; Kainic Acid; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Retina; Spheroids, Cellular; Synapses; Synaptic Transmission | 2002 |
Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cockroaches; Corpora Allata; Cycloleucine; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Juvenile Hormones; Kainic Acid; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina.
Topics: Algorithms; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Concanavalin A; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, Glutamate; Retina; Sodium | 2002 |
Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Phosphorylation; Rats; Receptors, Metabotropic Glutamate; Type C Phospholipases | 2002 |
Rat motoneuron cell death in development correlates with loss of N-methyl-D-aspartate receptors.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Electric Conductivity; Excitatory Amino Acid Agonists; Fluorescence; In Vitro Techniques; Iontophoresis; Isoquinolines; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2002 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Glutamic Acid; Kainic Acid; N-Methylaspartate; Osteoblasts; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; Skull | 2002 |
Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Deoxyglucose; Dizocilpine Maleate; DNA; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Mice, Knockout; Motor Activity; Phenotype; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Calcium; Calmodulin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Feedback; Female; Glutamic Acid; Imidazoles; Imines; Isoenzymes; Isoproterenol; Isoquinolines; Kainic Acid; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Propranolol; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Presynaptic; Second Messenger Systems; Sulfonamides; Synaptic Transmission; Trifluoperazine | 2003 |
Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Feeding Behavior; Kainic Acid; Lepidoptera; N-Methylaspartate; Plant Leaves | 2003 |
Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Culture Techniques; Cell Differentiation; Cell Survival; Ciliary Neurotrophic Factor; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fibroblast Growth Factors; Immunoblotting; Immunohistochemistry; Kainic Acid; Myelin Basic Protein; Oligodendroglia; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2003 |
Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents.
Topics: Adaptation, Physiological; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Kainic Acid; N-Methylaspartate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses | 2003 |
Glutamate modulation of GABA transport in retinal horizontal cells of the skate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carrier Proteins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Glutamic Acid; Intracellular Membranes; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Patch-Clamp Techniques; Retina; Skates, Fish | 2003 |
Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aza Compounds; Dicarboxylic Acids; Glutamic Acid; Inhibitory Concentration 50; Kainic Acid; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Mimicry; Molecular Structure; Norbornanes; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship | 2003 |
Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Glutamates; Indoles; Kainic Acid; Neurons; Protein Binding; Rats; Receptors, Glutamate; Tritium | 2002 |
Ionotropic glutamate receptors are involved in malondialdehyde production in anesthetized rat brain cortex: a microdialysis study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Brain; Brain Ischemia; Cerebral Cortex; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Excitatory Amino Acid Agonists; HeLa Cells; Humans; Kainic Acid; Malondialdehyde; Perfusion; Pyrrolidines; Rats; Receptors, Glutamate; Time Factors | 2003 |
Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice.
Topics: Acetylcysteine; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain; Catalase; Cell Death; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Electrons; Excitatory Amino Acid Agonists; Female; Humans; Kainic Acid; Male; Mice; Neurons; Peroxidases; Peroxiredoxins; Polyethylene Glycols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors | 2003 |
AMPA/kainate and group-I metabotropic receptor antagonists infused into different brain areas impair memory formation of inhibitory avoidance in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Avoidance Learning; Entorhinal Cortex; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Memory; Parietal Lobe; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2003 |
Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Calcium; Cells, Cultured; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Thiazines | 2003 |
Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Autoantibodies; Base Sequence; Cell Adhesion; Cell Membrane; Chemotaxis, Leukocyte; Clone Cells; Epitopes, T-Lymphocyte; Female; Fibronectins; Glutamic Acid; Humans; Immunoglobulin G; Integrins; Jurkat Cells; Kainic Acid; Laminin; Mice; Molecular Sequence Data; Rats; Rats, Inbred Lew; Receptors, AMPA; RNA, Messenger; T-Lymphocyte Subsets; Tumor Cells, Cultured | 2003 |
Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dentate Gyrus; Hippocampus; Kainic Acid; Nerve Degeneration; Neuroprotective Agents; Organ Culture Techniques; Pyramidal Cells; Rats; Receptors, Neuropeptide; Receptors, Neuropeptide Y | 2003 |
AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Blotting, Western; Cells, Cultured; Central Nervous System Depressants; Diagonal Band of Broca; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Male; Membrane Potentials; Models, Animal; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2003 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
Ethanol inhibits alpha-amino-3-hydyroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function in central nervous system neurons by stabilizing desensitization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Substitution; Animals; Benzothiadiazines; Cells, Cultured; Central Nervous System; Central Nervous System Depressants; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Leucine; Membrane Potentials; Mice; Mice, Inbred C57BL; Mutation; Neurons; Pyramidal Cells; Receptors, AMPA; Tyrosine | 2003 |
The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Hippocampus; Isoxazoles; Kainic Acid; Muscimol; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Propidium; Pyramidal Cells; Rats; Rats, Wistar; Time Factors | 2003 |
Intracellular calcium release resulting from mGluR1 receptor activation modulates GABAA currents in wide-field retinal amacrine cells: a study with caffeine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amacrine Cells; Animals; Anticoagulants; Bicuculline; Caffeine; Calcium; Calcium Channels; Carps; Cells, Cultured; Central Nervous System Stimulants; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Conductivity; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Heparin; Immunohistochemistry; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kainic Acid; Membrane Potentials; Methoxyhydroxyphenylglycol; Organophosphorus Compounds; Patch-Clamp Techniques; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Retina; Ryanodine | 2003 |
RNA synthesis-dependent potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated toxicity by antihistamine terfenadine in cultured rat cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Aniline Compounds; Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebellum; Dactinomycin; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Histamine; Histamine H1 Antagonists; Kainic Acid; Neurons; Protein Synthesis Inhibitors; Rats; Receptors, AMPA; RNA; Terfenadine; Xanthenes | 2003 |
Decreased dendrite growth from cultured mouse cortical neurons surviving excitotoxic activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Dendrites; Drug Interactions; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Neurofilament Proteins; Neurons; Time Factors | 2003 |
Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dopamine; Dopamine Agonists; Enzyme Activation; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Retina | 2003 |
The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microdialysis; Models, Animal; Oxidopamine; Parkinson Disease; Potassium; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2003 |
Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line; Chemical Phenomena; Chemistry, Physical; Egtazic Acid; Electric Conductivity; Embryo, Mammalian; Embryo, Nonmammalian; Female; Gene Expression; Glutamic Acid; Humans; Hydrogen Bonding; Ion Channels; Kainic Acid; Kidney; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Subunits; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Recombinant Fusion Proteins; Recombinant Proteins; Structure-Activity Relationship; Transfection; Xenopus laevis | 2003 |
Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Line; Cerebellar Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; Ligands; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Substrate Specificity | 2003 |
GABA and glutamate receptors are involved in modulating pacemaker activity in hydra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Culture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hydra; Kainic Acid; Quinoxalines; Receptors, GABA; Receptors, Glutamate | 2003 |
Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Lineage; Cell Survival; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stem Cells | 2003 |
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2alpha,3beta,4beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Binding Sites; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Models, Molecular; Molecular Sequence Data; Molecular Structure; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2003 |
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzamides; Brain Injuries; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; NAD; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Time Factors | 2004 |
Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebellum; Cerebral Cortex; Female; Fructose; Hippocampus; Ion Transport; Kainic Acid; Mice; Neurons; Pregnancy; Topiramate | 2004 |
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cellular Senescence; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Eye Proteins; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Picrotoxin; Receptors, AMPA; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Taurine | 2004 |
Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Burns; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Injections, Spinal; Kainic Acid; Motor Cortex; Pain; Pain Threshold; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spider Venoms | 2004 |
Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcium; Cells, Cultured; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression; Kainic Acid; L-Lactate Dehydrogenase; Neurotoxins; Oligodendroglia; Quinoxalines; Rats; Receptors, AMPA; Receptors, Androgen; Receptors, Kainic Acid; Testosterone; Time Factors | 2004 |
AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Line; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kainic Acid; Microfilament Proteins; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; rho-Associated Kinases; rhoA GTP-Binding Protein | 2004 |
Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Crystallography, X-Ray; Cysteine; Disulfides; Glutamic Acid; Humans; Hydrogen Bonding; Kainic Acid; Ligands; Molecular Conformation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Glutamate; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Water | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Administration Routes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Hindlimb; Kainic Acid; Lumbosacral Region; Male; Microdialysis; Motor Neurons; N-Methylaspartate; Paralysis; Perfusion; Potassium; Potassium Channel Blockers; Rats; Receptors, AMPA; Spinal Cord | 2004 |
Expression of functional kainate and AMPA receptors in developing lateral superior olive neurons of the rat.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Capacitance; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, Kainic Acid | 2004 |
Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basidiomycota; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Heterocyclic Compounds; Indoles; Injections, Spinal; Japan; Kainic Acid; Lumbosacral Region; Male; Mice; Mice, Inbred Strains; Mushroom Poisoning; Oximes; Pain; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2004 |
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Line; Female; Humans; Kainic Acid; Kinetics; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Fibers; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Spinal Nerve Roots | 2004 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nefopam; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sodium Channels; Synaptic Transmission; Tritium | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
Modulation of synaptic strength: subunit expression controls the critical period. Focus on "viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptors and restores NT-3-Induced potentiation of AMPA-kainate responses in maturing rat motoneurons".
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Critical Period, Psychological; Excitatory Amino Acid Agonists; Genetic Vectors; Kainic Acid; Magnesium; Motor Neurons; Neuronal Plasticity; Neurotrophin 3; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Synapses | 2004 |
Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina.
Topics: Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bone Morphogenetic Proteins; Enzyme Inhibitors; Humans; Kainic Acid; Middle Aged; Receptors, AMPA; Receptors, Kainic Acid; Retina | 2004 |
Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Astrocytes; Blotting, Western; Brain; Calcium; Cell Survival; Cells, Cultured; Female; Glutamic Acid; Humans; Kainic Acid; Male; Middle Aged; Oligodendroglia; Rats; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity | 2004 |
Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Circadian Rhythm; Cytochalasin D; Cytoskeleton; Dicarboxylic Acids; Dopamine; Eye Proteins; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Nocodazole; Potassium; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synaptic Transmission; Xanthenes | 2004 |
Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aromatase; Coturnix; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; Isonicotinic Acids; Kainic Acid; Male; N-Methylaspartate; Neurons; Norepinephrine; Preoptic Area; Pyridazines; Sympathomimetics | 2004 |
Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line; Electric Conductivity; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Mutation; Protein Engineering; Receptors, AMPA; Receptors, Kainic Acid | 2004 |
Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred BALB C; Neurons; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Transfection; Tumor Cells, Cultured; Xenon | 2005 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures | 2005 |
D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; D-Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Membrane Potentials; Microinjections; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Complementary; Stereoisomerism; Xenopus laevis | 2005 |
Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoquinolines; Isoxazoles; Kainic Acid; Male; Motor Activity; Propionates; Rats; Receptors, AMPA; Receptors, Kainic Acid | 2005 |
Cortical glutamatergic markers in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; In Situ Hybridization; Kainic Acid; Male; Middle Aged; Postmortem Changes; Radioligand Assay; Receptors, Glutamate; Schizophrenia; Tritium | 2005 |
Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebral Cortex; Chelating Agents; Dose-Response Relationship, Radiation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Mice; Models, Neurological; Monte Carlo Method; Neural Conduction; Neural Pathways; Neurons; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Strontium; Synapses; Synaptic Transmission; Thalamus; Time Factors | 2005 |
Physiological role for casein kinase 1 in glutamatergic synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Casein Kinase 1 epsilon; Casein Kinase I; Casein Kinase Ialpha; Casein Kinase Idelta; Corpus Striatum; Egtazic Acid; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neocortex; Nerve Tissue Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 2005 |
Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients.
Topics: Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Autoradiography; Case-Control Studies; Demography; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Humans; Kainic Acid; Male; Middle Aged; Postmortem Changes; Protein Binding; Receptors, Glutamate; Schizophrenia; Tritium | 2005 |
Glutamate receptor-mediated effects on growth and morphology of human histiocytic lymphoma cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Proliferation; Cell Shape; Culture Media, Serum-Free; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Humans; Kainic Acid; Lymphoma, Large B-Cell, Diffuse; Microscopy, Electron; Receptors, Glutamate; Time Factors; U937 Cells | 2005 |
Electrophysiological properties of human hypothalamic hamartomas.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Bicuculline; Cadmium Chloride; Child; Child, Preschool; Drug Interactions; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Glutamic Acid; Hamartoma; Humans; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Infant; Isoenzymes; Kainic Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Periodicity; Phosphopyruvate Hydratase; Potassium Channel Blockers; Tetraethylammonium; Tetrodotoxin; Valine | 2005 |
Mitochondrial superoxide production and MnSOD activity after exposure to agonist and antagonists of ionotropic glutamate receptors in hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Injections; Kainic Acid; Mitochondria; N-Methylaspartate; Rats; Receptors, Kainic Acid; Superoxide Dismutase; Superoxides; Time Factors | 2005 |
Rapid control of brain aromatase activity by glutamatergic inputs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aromatase; Brain; Coturnix; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate | 2006 |
Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Cadmium Chloride; Calcium; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Protein Subunits; Receptors, Kainic Acid; Substantia Gelatinosa | 2005 |
TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Neuronal Plasticity; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Rats; Receptors, AMPA; Synapses; Synaptic Transmission; Transfection | 2005 |
Estradiol modulation of kainic acid-induced calcium elevation in neonatal hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Brain; Calcium; Cells, Cultured; Estradiol; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Hippocampus; Kainic Acid; Microscopy, Fluorescence; Neurons; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors | 2006 |
Mapping glutamate responses in immunocytochemically identified neurons of the mouse retina.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Count; Excitatory Amino Acids; Kainic Acid; Lewis X Antigen; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Receptors, Glutamate; Retina; Tissue Distribution | 2006 |
Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate | 2006 |
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzodiazepines; Cadmium Chloride; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Receptors, AMPA; Receptors, Presynaptic; Spinal Cord | 2006 |
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Carbachol; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Movement; Cells, Cultured; Chelating Agents; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fibronectins; Glutamic Acid; Immunohistochemistry; Immunoprecipitation; Integrin alphaV; Ionophores; Kainic Acid; Models, Biological; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Pertussis Toxin; Quinoxalines; Rats; Receptor, Platelet-Derived Growth Factor alpha; Receptors, AMPA; Ruthenium Red; Stem Cells; Thapsigargin | 2006 |
Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hypothalamus; Kainic Acid; N-Methylaspartate; Ovariectomy; Rats; Rats, Long-Evans; Receptors, Glutamate; Sexual Behavior, Animal | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 2006 |
A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Beta Rhythm; Excitatory Amino Acid Agonists; Gap Junctions; Kainic Acid; Male; Nerve Net; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Somatosensory Cortex | 2006 |
Role of the chemical interactions of the agonist in controlling alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Line; Fluorescence Resonance Energy Transfer; Glutamic Acid; Humans; Kainic Acid; Mutation, Missense; Protein Binding; Protein Conformation; Receptors, AMPA; Spectroscopy, Fourier Transform Infrared; Transfection | 2007 |
Quantal release of ATP in mouse cortex.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Glutamate; Suramin | 2007 |
Modulation of [3H]dopamine release by glutathione in mouse striatal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione; Glutathione Disulfide; Kainic Acid; Mice; Oxidation-Reduction; Potassium; Tritium | 2007 |
Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by D-cycloserine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloserine; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Presynaptic AMPA and kainate receptors increase the size of GABAergic terminals and enhance GABA release.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzodiazepines; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Membrane Potentials; Mice; Mice, Transgenic; Presynaptic Terminals; Receptors, AMPA; Receptors, Kainic Acid | 2007 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Caspase 3; Cell Death; Cell Survival; Chondroitin Sulfates; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polyelectrolytes; Polymers; Pregnancy; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Morphological features and responses to AMPA receptor-mediated excitotoxicity of mouse motor neurons: comparison in purified, mixed anterior horn or motor neuron/glia cocultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Annexin A5; Anterior Horn Cells; Caspase 3; Caspase 9; Cell Death; Cell Separation; Cell Survival; Coculture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Fluorescent Dyes; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; Motor Neurons; Neuroglia; Receptors, AMPA | 2008 |
Glutamate mediates platelet activation through the AMPA receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Platelets; Glutamic Acid; Humans; In Vitro Techniques; Ion Transport; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Platelet Activation; Receptors, AMPA; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium; Thrombosis | 2008 |
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Memantine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2008 |
NMDA and GABA B receptors are involved in controlling nematocyst discharge in hydra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dose-Response Relationship, Drug; Epinephrine; Glutamic Acid; Glycine; Hydra; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, GABA-B; Serotonin | 2008 |
N-Methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involved in the induction of sedative effects under an acute stress in neonatal chicks.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chickens; Excitatory Amino Acid Agonists; Glutamic Acid; Immobility Response, Tonic; Kainic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2009 |
Blocking glutamate receptors in the waist area of the parabrachial nucleus decreases taste reactivity behaviors in conscious rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Taste | 2009 |
GABA(A)- and AMPA-like receptors modulate the activity of an identified neuron within the central pattern generator of the pond snail Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Brain; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurons; Picrotoxin; Receptors, AMPA; Receptors, GABA-A; Respiration | 2009 |
Ab initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2 alpha, 3 beta, 4 beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Behavior; Brain; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Molecular Sequence Data; Mutation; Proline; Quantum Theory; Receptors, AMPA; Thermodynamics; Tyrosine | 2009 |
Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Central Nervous System Stimulants; Endopeptidases; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Recombinant Proteins; Small Ubiquitin-Related Modifier Proteins; SUMO-1 Protein; Synaptic Transmission; Synaptosomes | 2009 |
Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Quisqualic Acid; Staurosporine; Thyrotropin-Releasing Hormone | 2009 |
Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cycloleucine; Dose-Response Relationship, Drug; Drosophila; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamates; Kainic Acid; Larva; Neuromuscular Junction; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2009 |
Glutamate controls growth rate and branching of dopaminergic axons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Calcineurin Inhibitors; Calcium; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Dopamine; Glutamic Acid; Growth Cones; Intracellular Space; Kainic Acid; Mesencephalon; Mice; Mice, Transgenic; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ryanodine Receptor Calcium Release Channel | 2009 |
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Humans; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Receptors, Kainic Acid; Structure-Activity Relationship; Time Factors; Transfection; Tritium | 2010 |
Characteristics and functions of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors expressed in mouse pancreatic {alpha}-cells.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Channels; Cell Size; Electrophysiology; Excitatory Amino Acid Agonists; Exocytosis; Glucagon; Glucagon-Secreting Cells; Glutamic Acid; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Kainic Acid; Male; Membrane Potentials; Mice; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; GluK2 Kainate Receptor; Hippocampus; Isomerism; Kainic Acid; Male; Models, Molecular; Molecular Conformation; Neuromuscular Depolarizing Agents; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Synaptosomes; Tritium | 2010 |
Involvement of AMPA/kainate-excitotoxicity in MK801-induced neuronal death in the retrosplenial cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Cell Death; Cerebral Cortex; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Limbic System; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2010 |
Reciprocal regulation between taurine and glutamate response via Ca2+-dependent pathways in retinal third-order neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amacrine Cells; Ambystoma; Animals; Calcium; Calcium Channels; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; Glycine Agents; Kainic Acid; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Neurotransmitter Agents; Patch-Clamp Techniques; Picrotoxin; Receptors, Glutamate; Retinal Ganglion Cells; Signal Transduction; Strychnine; Synaptic Transmission; Taurine | 2010 |
Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Blotting, Western; Calcium; Cells, Cultured; Curcumin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 2011 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Computer Simulation; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Models, Biological; Time Factors | 2010 |
Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biotinylation; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; In Vitro Techniques; Inflammation; Kainic Acid; Male; Microscopy, Immunoelectron; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Receptors, AMPA; Spinal Cord | 2011 |
Kainate receptors mediate regulated exocytosis of secretory phospholipase A(2) in SH-SY5Y neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Line, Tumor; Cells, Cultured; Excitatory Amino Acid Agonists; Exocytosis; Group II Phospholipases A2; Humans; Kainic Acid; Neurons; Rats; Receptors, Kainic Acid; Signal Transduction | 2012 |
Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Arterioles; Astrocytes; Carbon Monoxide; Cells, Cultured; Cerebrovascular Circulation; Female; Glutamates; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kainic Acid; Male; Models, Animal; N-Methylaspartate; Receptors, Glutamate; Swine; Vasodilation | 2012 |
In vitro studies of the influence of glutamatergic agonists on the Na+,K(+)-ATPase and K(+)-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats.
Topics: 4-Nitrophenylphosphatase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 2012 |
Presynaptic kainate receptor-mediated facilitation of glutamate release involves Ca2+ -calmodulin at mossy fiber-CA3 synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CA3 Region, Hippocampal; Calcium; Calmodulin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, Kainic Acid; Synaptosomes | 2012 |
[Inhibitory regulation of glutamate receptors in the frog motoneuron].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acids; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Microelectrodes; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Poisons; Pyridazines; Rana ridibunda; Receptors, Ionotropic Glutamate; Spinal Cord; Strychnine | 2012 |
Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclohexylamines; Disease Models, Animal; Ganglia, Spinal; Glutamic Acid; Kainic Acid; Male; Neurons; Peripheral Nerve Injuries; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sciatic Nerve | 2014 |
Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cell Differentiation; Cell Line; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrophysiology; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Quinoxalines; Receptors, Ionotropic Glutamate | 2014 |
Effects of NMDA and non-NMDA ionotropic glutamate receptors in the medial preoptic area on body temperature in awake rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Kainic Acid; Locomotion; Male; Preoptic Area; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Ionotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2016 |
Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats.
Topics: Affect; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Citalopram; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Limbic Lobe; Male; Neuroglia; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Quinoxalines; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Veratridine | 2017 |
Genetic and Functional Analysis of GRIN2A in Tumor Samples.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Movement; High-Throughput Nucleotide Sequencing; Humans; Kainic Acid; Melanoma; Mutation; Nerve Tissue Proteins; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Barrier; Disease Models, Animal; Gene Expression Regulation; Inflammation; Kainic Acid; Male; MicroRNAs; Nerve Degeneration; Oocytes; Oxidative Stress; Rats, Sprague-Dawley; Receptors, GABA; Seizures; Status Epilepticus; Xenopus | 2018 |
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dopamine; Kainic Acid; Mice, Inbred C57BL; Motor Cortex; Neural Pathways; Neurons; Receptors, Dopamine D5; Subthalamic Nucleus; Synapses; Synaptic Transmission | 2018 |
Glutamatergic activation of A1 and A2 noradrenergic neurons in the rat brain stem.
Topics: Adrenergic Neurons; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Excitatory Amino Acid Agents; Female; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Tyrosine 3-Monooxygenase | 2019 |
Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gene Expression Profiling; Hippocampus; Kainic Acid; Neurons; Rats, Sprague-Dawley; Receptors, AMPA; Seizures | 2020 |
AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis.
Topics: Adolescent; Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Inflammation; Kainic Acid; Male; Mice, Inbred C57BL; Osteoarthritis | 2020 |
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Agonists; Female; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kainic Acid; Male; Melatonin; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Pertussis Toxin; Puberty; Receptors, Kainic Acid | 2020 |
A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2021 |
The continually evolving role of NMDA receptors in neurobiology and disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid; N-Methylaspartate; Neurobiology; Receptors, N-Methyl-D-Aspartate | 2022 |
Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blastocyst; Excitatory Amino Acid Agonists; Female; Food Additives; Glutamates; Kainic Acid; Mice; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Salts; Sodium Glutamate | 2022 |
Rehabilitation on a treadmill induces plastic changes in the dendritic spines of spinal motoneurons associated with improved execution after a pharmacological injury to the motor cortex in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Dendritic Spines; Female; Kainic Acid; Motor Cortex; Motor Neurons; Rats; Rats, Sprague-Dawley | 2022 |
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Anti-Inflammatory Agents; Carbamazepine; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Hippocampus; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kainic Acid; N-Methylaspartate; Rats; Receptors, Interleukin-1; Rutin; Seizures; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |