Compounds > alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and gyki 52466

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with gyki 52466 in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	35 (62.50)	18.2507
2000's	20 (35.71)	29.6817
2010's	1 (1.79)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chapman, AG; Meldrum, BS; Smith, SE	1
Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C	1
Meldrum, BS; Smith, SE	1
Payne, RS; Rigor, BM; Schurr, A	1
Barnes, KA; Buchan, AM; Huang, ZG; Lesiuk, H; Li, H; Smith, KE; Xue, D	1
Rogawski, MA	1
Barnes, K; Buchan, AM; Huang, ZG; Lesiuk, HJ; Smith, KE; Xue, D	1
Burnett, JP; May, PC; Mayne, NG; Sharp, RL; Snyder, YM	1
Gyevai, A; Mike, A; Osipenko, O; Vizi, ES	1
Gruner, R; Parsons, CG; Rozental, J	1
Donevan, SD; Rogawski, MA; Yamaguchi, S	2
Fattman, CL; Hoyt, KR; Rajdev, S; Reynolds, IJ	1
Audinat, E; Crépel, F; Renard, A	1
Balázs, R; Hack, N	1
Donevan, SD; Rogawski, MA	1
Durand, J; Engberg, I; Ouardouz, M; Tarnawa, I	1
Buchan, AM; Li, H	1
Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z	1
De Bernardi, R; Ferro, F; Fontana, G; Gemignani, A; Raiteri, M	1
Regan, RF	1
Cole, BJ; Stephens, DN	1
Ballyk, BA; Bath, CP; Bleakman, D; Bufton, HR; Kamboj, RK; Lodge, D; Palmer, AJ; Schoepp, DD; Sharpe, EF; Tarnawa, I; Woolley, ML	1
Egyed, A; Kovács, AD	1
Croucher, MJ; Patel, DR	1
Fontana, G; Gemignani, A; Marchese, S; Raiteri, M	1
Członkowska, A; Płaźnik, A; Siemiatkowski, M	1
Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G	1
Bartha, E; Horváth, EJ; Lovas, G; Palkovits, M; Szentkuty, E	1
Brandon, T; Miles, R; Strahlendorf, HK; Strahlendorf, JC	1
De Sarro, A; De Sarro, G; Gitto, R; Grasso, S; Micale, N; Quartarone, S; Zappalà, M	1
Blanco, R; de la Villa, P	1
Bechtel, WD; Brambilla, A; Brenner, M; Ceci, A; Ensinger, HA; Palluk, R; Sagrada, A; Weiser, T; Wienrich, M	1
Chan, PH; Keinänen, R; Koistinaho, J; Tikka, T; Vartiainen, N	1
Chen, Q; Reiner, A; Surmeier, DJ	1
Fincher, A; Frye, GD	1
Csillik-Perczel, V; Harsing, LG; Ling, I; Sólyom, S	1
Durkin, JP; Gendron, TF; MacLean, S; Mealing, G; Morley, P; Small, DL; Tremblay, R	1
Abrahám, G; Andrási, F; Berzsenyi, P; Csuzdi, E; Hámori, T; Hársing, LG; Horváth, G; Horváth, K; Kapus, G; Király, I; Ling, I; Pallagi, I; Patthy, M; Sólyom, S; Tarnawa, I	1
Caicedo, A; Jafri, MS; Roper, SD	1
Lees, GJ; Leong, W	1
Croucher, MJ; Patel, DR; Young, AM	1
Brenner, M; Löscher, W; Palluk, R; Pieper, M; Potschka, H; Weiser, T; Wienrich, M	1
Kristensen, BW; Noraberg, J; Zimmer, J	1
Li, S; Stys, PK	1
Banczerowski-Pelyhe, I; Gulyás-Kovács, A; Takács, J; Tarnawa, I; Világi, I	1
Frye, GD; Hsiao, SH	1
Caicedo, A; Eybalin, M; Puel, JL; Renard, N; Ruel, J	1
Bennett, SA; Cheung, EC; Cregan, SP; Ferguson, KL; McIntosh, WC; Melanson-Drapeau, L; Park, DS; Slack, RS; Vanderluit, JL	1
Gudz, TI; Komuro, H; Macklin, WB	1
Le Merrer, J; Stephens, DN	1
Erdélyi, F; Fiszman, ML; Szabó, G; Vicini, S	1
Brocke, K; Gratopp, A; Ikonomidou, C; Pohl, EE; Rzeski, W; Sifringer, M; Stepulak, A; Turski, L	1
Burrell, BD; Li, Q	1
Bhatt, D; Chung, WY; Cooper, RL; Lee, JY	1
Gonzaga, WJ; Hettes, SR; Heyming, TW; Nguyen, JK; Perez, S; Stanley, BG	1

Reviews

1 review(s) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and gyki 52466

Article	Year
Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends in pharmacological sciences, 1993, Volume: 14, Issue:9 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Central Nervous System Diseases; Humans; Ion Channels; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	1993

Article

Year

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines.

Trends in pharmacological sciences, 1993, Volume: 14, Issue:9

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Central Nervous System Diseases; Humans; Ion Channels; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate

1993

Other Studies

55 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and gyki 52466

Article	Year
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy research, 1991, Volume: 9, Issue:2 Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Female; Ibotenic Acid; Male; Mice; Mice, Inbred DBA; Postural Balance; Quinoxalines; Seizures	1991
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus. Neuroscience letters, 1991, Dec-09, Volume: 133, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains	1991
Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice. European journal of pharmacology, 1990, Oct-02, Volume: 187, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Cyanobacteria Toxins; Glutamine; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Kinetics; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Receptors, Drug; Receptors, N-Methyl-D-Aspartate	1990
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro. Neurochemistry international, 1995, Volume: 26, Issue:5 Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety Agents; Benzodiazepines; Diltiazem; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nifedipine; Pipecolic Acids; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate	1995
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists? Stroke, 1993, Volume: 24, Issue:12 Suppl Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Infarction; Cerebrovascular Disorders; Dizocilpine Maleate; Drug Administration Schedule; Injections, Intraperitoneal; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reperfusion	1993
Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Male; N-Methylaspartate; Pilot Projects; Quinoxalines; Rats; Rats, Inbred SHR; Sodium Chloride	1994
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes. European journal of pharmacology, 1994, Jan-01, Volume: 266, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cloning, Molecular; Humans; Kainic Acid; Oocytes; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Xenopus laevis	1994
Evidence that GYKI 52466, a novel non-NMDA antagonist enhances the decay of kainate-induced current in cultured chicken cortical neurons. Brain research. Developmental brain research, 1994, Feb-18, Volume: 77, Issue:2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Chick Embryo; Electrophysiology; Excitatory Amino Acid Antagonists; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines	1994
Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466). Neuropharmacology, 1994, Volume: 33, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Superior Colliculi	1994
Non-N-methyl-D-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: relationship to anticonvulsant activity. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid	1994
Cyclothiazide modulates AMPA receptor-mediated increases in intracellular free Ca2+ and Mg2+ in cultured neurons from rat brain. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Drug Synergism; Glutamic Acid; Kainic Acid; Magnesium; Neurons; Prosencephalon; Rats; Receptors, AMPA	1995
Evidence for two types of non-NMDA receptors in rat cerebellar Purkinje cells maintained in slice cultures. Neuropharmacology, 1995, Volume: 34, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Electrophysiology; Kainic Acid; Kinetics; Membrane Potentials; Neurotoxins; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate	1995
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies. Journal of neurochemistry, 1995, Volume: 65, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebellum; Cobalt; Concanavalin A; Excitatory Amino Acids; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Wheat Germ Agglutinins	1995
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron, 1993, Volume: 10, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Electric Conductivity; Excitatory Amino Acid Antagonists; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Synapses	1993
An analysis of synaptic transmission to motoneurones in the cat spinal cord using a new selective receptor blocker. Acta physiologica Scandinavica, 1993, Volume: 148, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cats; Electrophysiology; Female; Ibotenic Acid; Male; Motor Neurons; N-Methylaspartate; Spinal Cord; Synapses; Synaptic Transmission	1993
Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:6 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Diseases; Dizocilpine Maleate; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Prosencephalon; Quinoxalines; Rats; Rats, Wistar	1993
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. Epilepsy research, 1993, Volume: 15, Issue:3 Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures	1993
The non-competitive AMPA/kainate receptor antagonist, GYKI 52466, potentiates the anticonvulsant activity of conventional antiepileptics. European journal of pharmacology, 1995, Aug-15, Volume: 281, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroshock; Female; Mice; Mice, Inbred Strains; Motor Activity; Rats; Valproic Acid	1995
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons. Journal of neurochemistry, 1996, Volume: 66, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin	1996
The vulnerability of spinal cord neurons to excitotoxic injury: comparison with cortical neurons. Neuroscience letters, 1996, Jul-26, Volume: 213, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cobalt; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Spinal Cord; Staining and Labeling; Time Factors	1996
AMPA antagonists differ from NMDA antagonists in their effects on operant DRL and delayed matching to position tasks. Psychopharmacology, 1996, Volume: 126, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reinforcement, Psychology	1996
Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology, 1996, Volume: 35, Issue:12 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cell Line; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Humans; Kidney; Membrane Potentials; Molecular Structure; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Proteins; Spinal Cord; Structure-Activity Relationship; Transfection	1996
Protection against non-NMDA receptor-mediated excitotoxicity by GYKI 52466 in mature telencephalic cultures of the rat. Neurobiology (Budapest, Hungary), 1996, Volume: 4, Issue:1-2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Neurons; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Telencephalon	1996
Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat forebrain. European journal of pharmacology, 1997, Aug-06, Volume: 332, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Benzothiadiazines; Binding, Competitive; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neurons; Presynaptic Terminals; Prosencephalon; Rats; Rats, Wistar; Receptors, AMPA; Tetrodotoxin	1997
Neuropeptide Y release from cultured hippocampal neurons: stimulation by glutamate acting at N-methyl-D-aspartate and AMPA receptors. Neuroscience, 1997, Volume: 81, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antibody Specificity; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neurons; Neuropeptide Y; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin	1997
Some behavioral effects of AMPA/kainate receptor agonist and antagonists. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1997, Volume: 48, Issue:3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Conflict, Psychological; Drinking Behavior; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid	1997
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain. Journal of neurochemistry, 1998, Volume: 71, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium	1998
Neuroprotective effect of GYKI 52466 on AMPA-induced neurotoxicity in rat striatum. Neurobiology (Budapest, Hungary), 1998, Volume: 6, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Autoradiography; Benzodiazepines; Choline O-Acetyltransferase; Corpus Striatum; Excitatory Amino Acid Antagonists; Gliosis; Male; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley	1998
AMPA receptor-mediated alterations of intracellular calcium homeostasis in rat cerebellar Purkinje cells in vitro: correlates to dark cell degeneration. Neurochemical research, 1998, Volume: 23, Issue:11 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aniline Compounds; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cytoplasm; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Homeostasis; In Vitro Techniques; Microscopy, Confocal; Nerve Degeneration; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Xanthenes	1998
7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists. Bioorganic & medicinal chemistry letters, 1998, Apr-21, Volume: 8, Issue:8 Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Excitatory Amino Acid Antagonists; Indicators and Reagents; Mice; Mice, Inbred DBA; Molecular Structure; Motor Activity; Receptors, AMPA; Seizures; Structure-Activity Relationship	1998
Ionotropic glutamate receptors in isolated horizontal cells of the rabbit retina. The European journal of neuroscience, 1999, Volume: 11, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina	1999
BIIR 561 CL: a novel combined antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and voltage-dependent sodium channels with anticonvulsive and neuroprotective properties. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Batrachotoxins; Benzodiazepines; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Embryo, Mammalian; Glutamic Acid; In Vitro Techniques; Ischemic Attack, Transient; Male; Mexiletine; Mice; Neurons; Neuroprotective Agents; Oxadiazoles; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sodium Channel Blockers; Sodium Channels; Synaptosomes; Veratridine	1999
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons. Neuroscience, 1999, Volume: 93, Issue:3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anti-Anxiety Agents; Apoptosis; Benzodiazepines; Calcium Channels; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Humans; Meninges; Motor Neurons; Neurofilament Proteins; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord	1999
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization. Experimental neurology, 1999, Volume: 159, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate	1999
Sustained ethanol inhibition of native AMPA receptors on medial septum/diagonal band (MS/DB) neurons. British journal of pharmacology, 2000, Volume: 129, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Diagonal Band of Broca; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Septum of Brain; Up-Regulation	2000
Negative allosteric modulators of AMPA-preferring receptors inhibit [(3)H]GABA release in rat striatum. Neurochemistry international, 2000, Volume: 37, Issue:1 Topics: Allosteric Site; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Corpus Striatum; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA	2000
Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line. Neurological research, 2000, Volume: 22, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Biological Transport; Calcium; Cell Survival; DNA Primers; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Islets of Langerhans; Kainic Acid; Protein Kinase C; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spider Venoms; Tumor Cells, Cultured	2000
New non competitive AMPA antagonists. Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:8 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Design; Humans; Kainic Acid; Male; Mice; Molecular Structure; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Retina; Seizures; Structure-Activity Relationship	2000
In situ Ca2+ imaging reveals neurotransmitter receptors for glutamate in taste receptor cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Nov-01, Volume: 20, Issue:21 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Dextrans; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Microscopy, Confocal; N-Methylaspartate; Neurotransmitter Agents; Organic Chemicals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Taste Buds	2000
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466. Brain research, 2001, Jan-26, Volume: 890, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures	2001
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: a dual-label microdialysis study. Neuroscience, 2001, Volume: 102, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Carbon Radioisotopes; Corpus Striatum; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Microdialysis; Nootropic Agents; Potassium; Presynaptic Terminals; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Tritium	2001
In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Death; Dose-Response Relationship, Drug; Electric Stimulation; Female; Lethal Dose 50; Male; Mexiletine; Mice; Neuroprotective Agents; Oxadiazoles; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, AMPA; Sodium Channel Blockers	2001
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. Brain research, 2001, Oct-26, Volume: 917, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar	2001
Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter. Neuroscience, 2001, Volume: 107, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Benzodiazepines; Calcium; Dicarboxylic Acids; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Male; Membrane Potentials; Nerve Fibers, Myelinated; Neurotransmitter Uptake Inhibitors; Ouabain; Potassium; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, AMPA; Sodium; Sodium-Potassium-Exchanging ATPase; Spinal Cord; Thiourea	2001
Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats. Brain research bulletin, 2002, Oct-15, Volume: 59, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Anti-Anxiety Agents; Asphyxia Neonatorum; Behavior, Animal; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Movement Disorders; Neostriatum; Neuroprotective Agents; Neurotoxins; Rats; Receptors, AMPA; Synaptic Transmission	2002
AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure. Brain research. Developmental brain research, 2003, Apr-14, Volume: 142, Issue:1 Topics: Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Blotting, Western; Cells, Cultured; Central Nervous System Depressants; Diagonal Band of Broca; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Male; Membrane Potentials; Models, Animal; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA	2003
Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons. The European journal of neuroscience, 2004, Volume: 20, Issue:11 Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Cobalt; Cochlea; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Glycine; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Parvalbumins; Peptides, Cyclic; Permeability; Rats; Rats, Wistar; Receptors, AMPA; Spider Venoms	2004
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-09, Volume: 25, Issue:6 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures	2005
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-01, Volume: 26, Issue:9 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Carbachol; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Movement; Cells, Cultured; Chelating Agents; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fibronectins; Glutamic Acid; Immunohistochemistry; Immunoprecipitation; Integrin alphaV; Ionophores; Kainic Acid; Models, Biological; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Pertussis Toxin; Quinoxalines; Rats; Receptor, Platelet-Derived Growth Factor alpha; Receptors, AMPA; Ruthenium Red; Stem Cells; Thapsigargin	2006
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jul-05, Volume: 26, Issue:27 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Benzazepines; Benzodiazepines; Cocaine; Conditioning, Psychological; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Sulpiride	2006
Presynaptic AMPA and kainate receptors increase the size of GABAergic terminals and enhance GABA release. Neuropharmacology, 2007, Volume: 52, Issue:8 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzodiazepines; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Membrane Potentials; Mice; Mice, Transgenic; Presynaptic Terminals; Receptors, AMPA; Receptors, Kainic Acid	2007
AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer biology & therapy, 2007, Volume: 6, Issue:12 Topics: Adenocarcinoma; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Receptors, AMPA; Signal Transduction	2007
CNQX and AMPA inhibit electrical synaptic transmission: a potential interaction between electrical and glutamatergic synapses. Brain research, 2008, Sep-04, Volume: 1228 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Concanavalin A; Electrical Synapses; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gap Junctions; Leeches; Long-Term Potentiation; Long-Term Synaptic Depression; Mitogens; Receptors, AMPA; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Transmission	2008
Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2009, Volume: 150, Issue:4 Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cycloleucine; Dose-Response Relationship, Drug; Drosophila; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamates; Kainic Acid; Larva; Neuromuscular Junction; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synaptic Transmission	2009
Stimulation of lateral hypothalamic AMPA receptors may induce feeding in rats. Brain research, 2010, Jul-30, Volume: 1346 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Food Deprivation; Hypothalamic Area, Lateral; Injections; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism; Stimulation, Chemical	2010