alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline in 176 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 102 (57.95) | 18.2507 |
| 2000's | 54 (30.68) | 29.6817 |
| 2010's | 19 (10.80) | 24.3611 |
| 2020's | 1 (0.57) | 2.80 |
| Authors | Studies |
|---|---|
| Alt, A; Bleakman, D; Bortolotto, ZA; Collingridge, GL; Dolman, NP; Jack, S; Jane, DE; Knauss, JL; More, JC; Morley, RM; Nistico, R; Roberts, PJ; Troop, HM | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| England, PM; Fleming, JJ | 1 |
| Cox, JA; Seeburg, PH; Stein, E; Verdoorn, TA | 1 |
| Kunow, M; Löschmann, PA; Wachtel, H | 1 |
| Boddeke, HW; Massieu, L; Mengod, G; Palacios, JM; Rocamora, N | 1 |
| Honoré, T; Jacobsen, P; Stephens, DN; Turski, L | 1 |
| Parks, TN; Zhou, N | 1 |
| Lodge, D; Zeman, S | 1 |
| Bruhn, T; Diemer, NH; Frank, L | 2 |
| Balchen, T; Diemer, NH | 1 |
| East, SJ; Garthwaite, J | 1 |
| Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C | 1 |
| Honoré, T; Jähnig, P; Jenner, P; Kunow, M; Lange, KW; Löschmann, PA; Marsden, CD; Rettig, KJ; Turski, L; Wachtel, H | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Sheardown, MJ | 1 |
| Barnes, KA; Buchan, AM; Huang, ZG; Lesiuk, H; Li, H; Smith, KE; Xue, D | 1 |
| Anderton, BH; Leigh, PN; Meldrum, BS; Nunn, PB; Willis, CL | 1 |
| Lees, GJ; Leong, W | 3 |
| Barnes, K; Buchan, AM; Huang, ZG; Lesiuk, HJ; Smith, KE; Xue, D | 1 |
| Klitgaard, H; Laudrup, P | 1 |
| Brooker, G; Costa, E; de Erausquin, G; Hanbauer, I | 1 |
| Lookingland, KJ; Moore, KE; Wagner, EJ | 1 |
| Massieu, L; Tapia, R | 1 |
| Chizh, BA; Cumberbatch, MJ; Headley, PM | 2 |
| Gruner, R; Parsons, CG; Rozental, J | 1 |
| Greenamyre, JT; Greene, JG | 2 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Greenamyre, JT; Porter, RH | 1 |
| Andersen, PH; Jørgensen, M; Tygesen, CK | 1 |
| Bianchi, L; Camilli, F; Colivicchi, MA; Giovannini, MG; Mundula, A; Pepeu, G | 1 |
| Balázs, R; Hack, N | 1 |
| Drejer, J; Johansen, TH; Nielsen, EO; Wätjen, F | 1 |
| Abe, S; Akazawa, K; Nakamura, M | 1 |
| Christoffersen, CL; Meltzer, LT | 1 |
| Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM | 1 |
| Lodge, D; Palmer, AJ | 1 |
| Boldry, RC; Chase, TN; Engber, TM; Kelland, MD | 1 |
| French, ED; Wang, T | 1 |
| Guillén, J; Laguna, J; Luquin, MR; Martínez-Lage, JM; Obeso, JA | 1 |
| Honoré, T; Sheardown, MJ; Suzdak, PD | 1 |
| Nordholm, L; Sheardown, MJ; Suzdak, PD | 1 |
| Haldeman, B; Hampson, DR; Mulvihill, ER; Pickering, DS; Suzdak, PD; Thomsen, C | 1 |
| Buchan, AM; Li, H | 1 |
| Hammerland, LG; Parks, TN; Zhou, N | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, WA; Zarnowski, T | 1 |
| Dogas, Z; Hopp, FA; McCrimmon, DR; Stuth, EA; Zuperku, EJ | 1 |
| Choiniere, D; Teng, YD; Wrathall, JR | 1 |
| Cordi, AA; Desos, P; Lepagnol, JM; Lestage, P; Morain, P | 1 |
| Corbett, D; Nurse, S | 1 |
| Choi, EJ; Leem, JW; Paik, KS; Park, ES | 1 |
| Borsini, F; Brambilla, A; Grippa, N; Prudentino, A | 1 |
| Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M | 1 |
| Banke, T; Krogsgaard-Larsen, P; Madsen, U; Schousboe, A; Wahl, P | 1 |
| Kita, H | 1 |
| Beckstead, RM | 1 |
| Cole, BJ; Stephens, DN | 1 |
| Ben-Yoseph, O; Boxer, PA; Ross, BD | 1 |
| Bouazzaoui, M; Gombos, G; Kannengieser, C; Procksch, O | 1 |
| Alici, K; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Cebers, G; Hou, YN; Liljequist, S; Terenius, L | 1 |
| Kovács, AD; Szabó, G | 1 |
| Fontana, G; Gemignani, A; Marchese, S; Raiteri, M | 1 |
| Krassioukov, AV; Krenz, NR; Maiorov, DN; Weaver, LC | 1 |
| Bhat, GK; Brann, DW; Mahesh, VB; Ping, L | 1 |
| Cook, JC; Gregg, AE; Sanders, BJ; Soltis, RP | 1 |
| Ikonomidou, C; Turski, L | 1 |
| Członkowska, A; Płaźnik, A; Siemiatkowski, M | 1 |
| Chittajallu, R; Dev, KK; Henley, JM | 1 |
| Canzoniero, LM; Choi, DW; Grabb, M; Monyer, H; Sensi, SL; Sheline, CT; Weishaupt, JH; Ying, HS | 1 |
| Canzoniero, LM; Choi, DW; Kerchner, GA; Koh, JY; Sensi, SL; Ying, HS; Yu, SP | 1 |
| Fedele, E; Raiteri, M; Varnier, G | 1 |
| Bianchi, L; Della Corte, L; Giovannini, MG; Pepeu, G; Rakovska, A | 1 |
| Daggett, LP; Deal, C; Hess, SD; Jachec, C; Johnson, EC; Lin, F; Rao, SP; Varney, MA; Veliçelebi, G | 1 |
| Bonnot, A; Bouc, AM; Corio, M; Viala, D | 1 |
| Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G | 1 |
| Mifflin, SW; Zhang, J | 1 |
| Holmberg, L; Souverbie, F; Sundström, E | 1 |
| Behl, B; Hofmann, HP; Löscher, W; Potschka, H; Szabo, L; Treiber, HJ; Wlaź, P | 1 |
| Higashiyama, A; Ishida, N; Kato, N; Yasuda, S | 1 |
| Curry, K; Pajouhesh, H | 1 |
| Aguilar, E; González, LC; Pinilla, L; Tena-Sempere, M | 4 |
| Armstrong, WE; Foehring, RC; Galarreta, M; Hestrin, S; Stern, JE | 1 |
| Cagnotto, A; Carvelli, L; Comoletti, D; Manzoni, C; Mennini, T; Muzio, V; Rizzi, M; Vezzani, A | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Arvigo, D; Bonfanti, A; Pittaluga, A; Raiteri, M | 1 |
| Dogas, Z; Hopp, FA; Krolo, M; McCrimmon, DR; Stuth, EA; Tonkovic-Capin, M; Zuperku, EJ | 1 |
| Cohen, ED; Miller, RF | 1 |
| Bizot, JC; Puma, C | 1 |
| Chan, PH; Hirvonen, T; Keinänen, R; Koistinaho, J; Koponen, S; Närhi, M; Roivainen, R | 1 |
| Bleakman, D; Hoo, K; Ogden, AM; Ornstein, PL | 1 |
| Dean, C; Hopp, FA; Seagard, JL | 1 |
| Ebert, B; Gramsbergen, JB; Jakobsen, B; Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Livingston, FS; Mooney, R; White, SA | 1 |
| Cummins, DJ; Dewar, D; Dragunow, M; Mahy, N; Petegnief, V; Saura, J | 1 |
| Cole, DJ; Drummond, JC; Kelly, PJ; Kimbro, JR; Patel, PM | 1 |
| Bräuner-Osborne, H; Eriksen, L; Krogsgaard-Larsen, P; Lützhøft, HH; Madsen, U; Poulsen, MV; Sløk, FA; Stensbøl, TB | 1 |
| Pollard, M | 1 |
| Kurasawa, M; Nakamura, K; Shirane, M | 1 |
| Durand, J; Ruiz, A | 1 |
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Friedman, D; Strowbridge, BW | 1 |
| Higashiyama, A; Ishida, N; Kato, N; Morinobu, S; Yasuda, S | 1 |
| Closier, M; Iop, F; Lestage, P; Lockhart, B | 1 |
| Kondo, M; Okabe, S; Okado, H; Sumino, R | 1 |
| Allan, SM; Rothwell, NJ | 1 |
| Ikonomidou, C; Stefovska, V; Turski, L | 1 |
| Follett, PL; Jensen, FE; Rosenberg, PA; Volpe, JJ | 1 |
| Shi, WX; Zhang, XX | 1 |
| Croucher, MJ; Patel, DR; Young, AM | 1 |
| Brenner, M; Löscher, W; Palluk, R; Pieper, M; Potschka, H; Weiser, T; Wienrich, M | 1 |
| Canonico, PL; Dianzani, C; Fantozzi, R; Lombardi, G; Miglio, G | 1 |
| Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Jakobsen, B; Zimmer, J | 1 |
| Dikranian, K; Farber, NB; Heinkel, C; Jiang, XP; Kim, SH | 1 |
| Christensen, KV; Dai, WM; Ebert, B; Egebjerg, J; Lambert, JD | 1 |
| Attwell, D; Hamann, M; Marie, H; Rossi, DJ | 1 |
| Allgaier, C; Fischer, W; Franke, H; Illes, P; Scheibler, P | 1 |
| Chiang, AS; Lin, SC; Liu, HP; Pszczolkowski, MA | 1 |
| Hagimura, N; Ishiuchi, S; Kurihara, H; Miwa, A; Nakazato, Y; Okado, H; Ozawa, S; Sasaki, T; Tamura, M; Tsuzuki, K; Yamada, N; Yoshida, Y | 1 |
| Fujimori, S; Hinoi, E; Takarada, T; Taniura, H; Yoneda, Y | 1 |
| Adell, A; Amargós-Bosch, M; Artigas, F; Bortolozzi, A; Díaz-Mataix, L; Pons, S; Serrats, J | 1 |
| Kass-Simon, G; Pannaccione, A; Pierobon, P | 1 |
| Gonzaga, J; Hettes, SR; Heyming, TW; Perez, S; Stanley, BG; Wolfsohn, S | 1 |
| Billups, B; Forsythe, ID; Hamann, M | 1 |
| Duan, SM; Xu, AJ; Zeng, YM | 1 |
| Cory-Slechta, DA; Reeves, R; Thiruchelvam, M | 1 |
| Hamanaka, N; Ito, S; Matsumura, S; Minami, T; Nishizawa, M; Sasaguri, Y | 1 |
| Coutinho, V; Knöpfel, T; Mutoh, H | 1 |
| Komatsu, Y; Takada, N; Yanagawa, Y | 1 |
| Brennan, TJ; Pogatzki-Zahn, EM; Zahn, PK | 1 |
| Hashikawa, T; Hayashi, Y; Kobayashi, S; Miyawaki, A; Nagai, T; Nakagawa, T; Neve, RL; Okamoto, K; Takao, K | 1 |
| Knöpfel, T; Mutoh, H; Yuan, Q | 1 |
| Henry, B; Hill, DR; Horsburgh, K; Jordan, GR; McCulloch, J; Shahid, M | 1 |
| Bottjer, SW | 1 |
| Jahr, CE; Wadiche, JI | 1 |
| Ben-Ari, Y; Crépel, V; Epsztein, J; Jorquera, I; Represa, A | 1 |
| An, TH; Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH | 1 |
| Iino, M; Kakizawa, S; Kano, M; Miyazaki, T; Watanabe, M; Yanagihara, D | 1 |
| Gudz, TI; Komuro, H; Macklin, WB | 1 |
| Dolman, NP; Ghosal, A; Jane, DE; Mayer, ML | 1 |
| Ishiuchi, S; Ozawa, S; Tsuzuki, K; Yoshida, Y | 1 |
| Liu, SJ | 1 |
| Crair, MC; Shah, RD | 1 |
| Asrar, S; Huang, WW; Jia, Z; Meng, Y; Todorovski, Z; Zhou, Z | 1 |
| Dybała, M; Nowak, G; Pilc, A; Poleszak, E; Siwek, A | 1 |
| Mahmoudian, M; Rahbar-Roshandel, N; Rahimi-Moghaddam, P; Tavakoli-Far, B | 1 |
| Nakagawa, T | 1 |
| Carrillo, M; Melloni, RH; Ricci, LA | 1 |
| Babai, N; Chambers, JJ; Jackman, SL; Kramer, RH; Thoreson, WB | 1 |
| Harley, CW; Yuan, Q | 1 |
| Behnisch, T; Chen, Y; Huang, Y; Zhu, G; Zhuang, Y | 1 |
| Mejia-Gervacio, S | 1 |
| Nicoll, RA; Shipman, SL | 1 |
| Ben Hamida, S; Carnicella, S; Darcq, E; Gibb, SL; Lanfranco, MF; Ron, D; Wang, J; Zhu, W | 1 |
| Fukui, K; Ishiwata, S; Nishikawa, T; Umino, A; Umino, M; Yorita, K | 1 |
| Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC | 1 |
| Carr, JA; Fu, Z; Go, A; Pamenter, ME; Powell, FL; Reid, SG | 1 |
| Fukushima, K; Imaizumi, Y; Ito, M; Kohmura, N; Sawada, K; Sugawara, M; Tabata, Y; Yamazaki, K | 1 |
| Asensio, CS; Edwards, RH; Incontro, S; Nicoll, RA | 1 |
| Cuéllar, R; de Álvarez-Buylla, ER; Dobrovinskaya, O; García-Estrada, J; Lemus, M; Luquín, S; Melnikov, V; Montero, S | 1 |
| Kurosawa, N; Seki, K; Shimizu, K | 1 |
| Chung, HJ; Jewett, KA; Lee, KY; Man, HY; Tsai, NP; Zhu, J | 1 |
| Artigas, F; Castañé, A; Gasull-Camós, J; Tarrés-Gatius, M | 1 |
| Carter, AG; McGarry, LM | 1 |
| Callison, JJ; Cook-Snyder, DR; McCarthy, N; Miller, JR; Navarrete-Opazo, AA; Palkovic, B; Stucke, AG; Stuth, EAE; Zuperku, EJ | 1 |
2 review(s) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
| Article | Year |
|---|---|
The pharmacology of AMPA receptors and their antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Quinoxalines; Receptors, AMPA | 1993 |
The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Line; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Models, Molecular; Protein Conformation; Protein Subunits; Quinoxalines; Receptors, AMPA | 2010 |
174 other study(ies) available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
| Article | Year |
|---|---|
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Topics: Alanine; Animals; Animals, Newborn; Calcium; Cell Line; Humans; In Vitro Techniques; Long-Term Potentiation; Mossy Fibers, Hippocampal; Nerve Fibers, Unmyelinated; Protein Subunits; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Structure-Activity Relationship; Uracil | 2005 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Topics: Allosteric Regulation; Animals; Binding Sites; Ligands; Receptors, AMPA | 2010 |
Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Membrane Potentials; Oocytes; Quinoxalines; Receptors, AMPA; Receptors, Neurotransmitter; Recombinant Proteins; Xenopus laevis | 1992 |
NBQX (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and CPP (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Apomorphine; Dopamine Agents; Drug Synergism; Ibotenic Acid; Lisuride; Male; Neurons; Oxidopamine; Parkinson Disease, Secondary; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical | 1992 |
Administration of quinolinic acid in the rat hippocampus induces expression of c-fos and NGFI-A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Gene Expression Regulation; Genes, fos; Hippocampus; Ibotenic Acid; In Situ Hybridization; Injections, Intraperitoneal; Male; Oligonucleotide Probes; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
Relief of experimental spasticity and anxiolytic/anticonvulsant actions of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Electromyography; Ibotenic Acid; Kindling, Neurologic; Locomotion; Male; Mice; Muscle Spasticity; Quinoxalines; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1992 |
Developmental changes in the effects of drugs acting at NMDA or non-NMDA receptors on synaptic transmission in the chick cochlear nucleus (nuc. magnocellularis).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Chick Embryo; Cochlear Nerve; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Embryonic and Fetal Development; Evoked Potentials; Ibotenic Acid; N-Methylaspartate; Piperazines; Quinolinic Acid; Quinolinic Acids; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Methohexital; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Regional cerebral protein synthesis after transient ischemia in the rat: effect of the AMPA antagonist NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Ibotenic Acid; Ischemic Attack, Transient; Male; Methionine; Nerve Tissue Proteins; Neurons; Organ Specificity; Quinoxalines; Rats; Rats, Wistar; Sulfur Radioisotopes | 1992 |
The AMPA antagonist, NBQX, protects against ischemia-induced loss of cerebellar Purkinje cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Ibotenic Acid; Ischemic Attack, Transient; Male; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar | 1992 |
Actions of a metabotropic glutamate receptor agonist in immature and adult rat cerebellum.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebellum; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Purkinje Cells; Quinoxalines; Rats; Receptors, Glutamate | 1992 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Female; Ibotenic Acid; Male; Mice; Mice, Inbred DBA; Postural Balance; Quinoxalines; Seizures | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Callithrix; Disease Models, Animal; Drug Synergism; Ibotenic Acid; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1991 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Infarction; Cerebrovascular Disorders; Dizocilpine Maleate; Drug Administration Schedule; Injections, Intraperitoneal; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reperfusion | 1993 |
Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Rats; Rats, Wistar | 1993 |
Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Diazepam; Hippocampus; Injections; Kainic Acid; Limbic System; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Male; N-Methylaspartate; Pilot Projects; Quinoxalines; Rats; Rats, Inbred SHR; Sodium Chloride | 1994 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Persistent AMPA receptor stimulation alters [Ca2+]i homeostasis in cultures of embryonic dopaminergic neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Dopamine; Homeostasis; Mesencephalon; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1994 |
Non-NMDA receptor-mediated regulation of hypothalamic dopaminergic neurons in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Dopamine; Female; Hypothalamus; Kainic Acid; Male; Median Eminence; Neostriatum; Neurons; Paraventricular Hypothalamic Nucleus; Prolactin; Quinoxalines; Rats; Receptors, Amino Acid; Receptors, AMPA; Substantia Nigra | 1994 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 1994 |
AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Dose-Response Relationship, Drug; Iontophoresis; Male; N-Methylaspartate; Nociceptors; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord; Synapses; Synaptic Transmission | 1994 |
A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Hot Temperature; Injections, Intravenous; Iontophoresis; Male; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord | 1994 |
Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Superior Colliculi | 1994 |
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; Cell Death; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Isoquinolines; Male; Malonates; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase | 1995 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
Synergy between diazepam and NBQX in preventing neuronal death caused by non-NMDA agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Diazepam; Drug Synergism; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 1994 |
NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1994 |
Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain; Cerebellar Cortex; Glutamic Acid; Indoles; Male; Molecular Structure; Prosencephalon; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides | 1994 |
Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Diseases; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Male; Malonates; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase | 1995 |
The importance of two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Blotting, Western; Calcium; Cell Line; Cricetinae; Gene Expression; Kainic Acid; Kidney; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Transfection; Tritium | 1995 |
Differential regulation by N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of acetylcholine release from the rat striatum in vivo.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; gamma-Aminobutyric Acid; Male; Microdialysis; Neostriatum; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebellum; Cobalt; Concanavalin A; Excitatory Amino Acids; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Wheat Germ Agglutinins | 1995 |
Characterization of the binding of [3H]NS 257, a novel competitive AMPA receptor antagonist, to rat brain membranes and brain sections.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Cell Membrane; Cerebral Cortex; Hydrogen-Ion Concentration; Indoles; Kainic Acid; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sulfonamides; Thiocyanates; Tritium | 1995 |
AMPA-, but not NMDA-, receptor blocker, NBQX, prevents seizure induction in magnesium-deficient rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Magnesium Deficiency; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Evidence for N-methyl-D-aspartate and AMPA subtypes of the glutamate receptor on substantia nigra dopamine neurons: possible preferential role for N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Glutamic Acid; Iontophoresis; Male; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1995 |
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil | 1995 |
Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cerebral Cortex; Diuretics; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1993 |
NBQX inhibits AMPA-induced locomotion after injection into the nucleus accumbens.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Injections; Kainic Acid; Motor Activity; Nucleus Accumbens; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Electrophysiological evidence for the existence of NMDA and non-NMDA receptors on rat ventral tegmental dopamine neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 1993 |
The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine Agents; Excitatory Amino Acid Antagonists; Ibotenic Acid; Indoles; Macaca fascicularis; Motor Activity; Oxazines; Parkinson Disease; Phenanthridines; Quinoxalines; Receptors, AMPA; Receptors, Glutamate | 1993 |
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Gerbillinae; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kinetics; Male; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Aminobutyrates; Animals; Binding, Competitive; Cell Line; Cell Membrane; Clone Cells; Cricetinae; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kidney; Kinetics; Neurotoxins; Pertussis Toxin; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1993 |
The effect of an AMPA antagonist (NBQX) on postischemic neuron loss and protein synthesis in the rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Autoradiography; Brain; Frontal Lobe; Hippocampus; Ischemic Attack, Transient; Male; Methionine; Nerve Tissue Proteins; Neurons; Pyramidal Tracts; Quinoxalines; Rats; Rats, Wistar; Sulfur Radioisotopes; Thalamus | 1993 |
Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Diseases; Dizocilpine Maleate; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Prosencephalon; Quinoxalines; Rats; Rats, Wistar | 1993 |
Gamma-D-glutamylaminomethyl sulfonic acid (GAMS) distinguishes kainic acid- from AMPA-induced responses in Xenopus oocytes expressing chick brain glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Chick Embryo; Electrophysiology; Glutamine; Kainic Acid; Kinetics; Oocytes; Quinoxalines; Receptors, Glutamate; RNA, Messenger; Xenopus | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Behavior, Animal; Drug Synergism; Electroshock; Male; Memory; Mice; Motor Activity; Psychomotor Performance; Quinoxalines; Seizures | 1993 |
NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Dioxide; Carotid Body; Dogs; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Male; Medulla Oblongata; Microinjections; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics; Spinal Cord; Stimulation, Chemical; Synaptic Transmission; Vagotomy | 1995 |
Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Female; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries; Time Factors | 1996 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Kainic Acid; Mice; Molecular Structure; N-Methylaspartate; Neuroprotective Agents; Organophosphonates; Quinolones; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus | 1996 |
Neuroprotection after several days of mild, drug-induced hypothermia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain; Brain Ischemia; Gerbillinae; Hypothermia, Induced; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Reperfusion; Time Factors | 1996 |
N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Male; N-Methylaspartate; Neurons; Peripheral Nerve Injuries; Physical Stimulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1996 |
Pharmacological characterization of AMPA-induced biting behaviour in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1996 |
Novel AMPA receptor antagonists: synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Antagonists; Hydroxylation; Imidazoles; Molecular Structure; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tritium | 1996 |
Different characteristics of AMPA receptor agonists acting at AMPA receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Kainic Acid; Oocytes; Patch-Clamp Techniques; Quinoxalines; Receptors, AMPA; Xenopus laevis | 1996 |
Glutamatergic and GABAergic postsynaptic responses of striatal spiny neurons to intrastriatal and cortical stimulation recorded in slice preparations.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission | 1996 |
N-methyl-D-aspartate acutely increases proenkephalin mRNA in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; Histocytochemistry; In Situ Hybridization; Injections, Intraventricular; Male; N-Methylaspartate; Prosencephalon; Protein Precursors; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1995 |
AMPA antagonists differ from NMDA antagonists in their effects on operant DRL and delayed matching to position tasks.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reinforcement, Psychology | 1996 |
Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Isotopes; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Deferoxamine; Deuterium; Dizocilpine Maleate; Fetus; Gas Chromatography-Mass Spectrometry; Glucose; Hydrogen Peroxide; Iron; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Pentose Phosphate Pathway; Putamen; Quinoxalines; Rats | 1996 |
Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kinetics; Quinoxalines; Rats; Rats, Wistar; Tetrodotoxin; Tritium | 1996 |
Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1997 |
Characterization of NMDA- and AMPA-induced enhancement of AP-1 DNA binding activity in rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Cerebellum; Dizocilpine Maleate; DNA-Binding Proteins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Transcription Factor AP-1 | 1997 |
GYKI 53665, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1997 |
Neuropeptide Y release from cultured hippocampal neurons: stimulation by glutamate acting at N-methyl-D-aspartate and AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antibody Specificity; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neurons; Neuropeptide Y; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1997 |
Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Consciousness; Excitatory Amino Acid Antagonists; Heart Rate; Hypertension; Male; N-Methylaspartate; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord | 1997 |
Regulation of gonadotropin-releasing hormone and luteinizing hormone secretion by AMPA receptors. Evidence for a physiological role of AMPA receptors in the steroid-induced luteinizing hormone surge.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Luteinizing Hormone; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Ovariectomy; Preoptic Area; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1997 |
Interaction of GABA and excitatory amino acids in the basolateral amygdala: role in cardiovascular regulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Arousal; Bicuculline; Blood Pressure; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Picrotoxin; Piperazines; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1997 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Cerebral Cortex; Convulsants; Excitatory Amino Acid Antagonists; Exploratory Behavior; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Seizures | 1997 |
Some behavioral effects of AMPA/kainate receptor agonist and antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Conflict, Psychological; Drinking Behavior; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1997 |
Effect of thiol group modification on 3[H]-NBQX binding in rat cortical membranes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Chloromercuribenzoates; Disulfides; Dithiothreitol; Female; p-Chloromercuribenzoic Acid; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sulfhydryl Compounds | 1997 |
Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Glucose; Hippocampus; Ischemic Preconditioning; Kainic Acid; Nerve Tissue Proteins; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Spider Venoms | 1997 |
Measurement of intracellular free zinc in living cortical neurons: routes of entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Ionophores; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neocortex; Neurons; Nimodipine; Quinoxalines; Sodium-Calcium Exchanger; Zinc | 1997 |
In vivo microdialysis study of GABA(A) and GABA(B) receptors modulating the glutamate receptor/NO/cyclic GMP pathway in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Microdialysis; Nitric Oxide; Quinoxalines; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, GABA-B; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Microdialysis; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Tetrodotoxin | 1998 |
Pharmacological characterization of the human ionotropic glutamate receptor subtype GluR3 stably expressed in mammalian cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Binding, Competitive; Brain; Cells, Cultured; Diuretics; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Humans; Kidney; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1998 |
Involvement of AMPA receptors in posterior locomotor activity in the rabbit: an in vivo study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Decerebrate State; Electric Stimulation; Excitatory Amino Acid Antagonists; Hindlimb; Motor Activity; Quinoxalines; Rabbits; Receptors, AMPA | 1998 |
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium | 1998 |
Differential roles for NMDA and non-NMDA receptor subtypes in baroreceptor afferent integration in the nucleus of the solitary tract of the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Phenylephrine; Pressoreceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Synapses; Vasoconstrictor Agents | 1998 |
NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Dizocilpine Maleate; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Presynaptic Terminals; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 1998 |
LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinolones; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
[Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem].
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzothiadiazines; Brain Stem; Dizocilpine Maleate; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Inferior Colliculi; N-Methylaspartate; Neuroprotective Agents; Propylthiouracil; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Pharmacological profile of the isomers of the GluR-specific agonist ATPA.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Kynurenic Acid; Propionates; Quinoxalines; Rats; Receptors, Glutamate; Stereoisomerism | 1998 |
Regulation of growth hormone secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in infantile, prepubertal, and adult male rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Nitric Oxide; Pituitary Gland; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sexual Maturation | 1999 |
Differences in the properties of ionotropic glutamate synaptic currents in oxytocin and vasopressin neuroendocrine neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Hypothalamus; In Vitro Techniques; Neurons; Oxytocin; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Synapses; Vasopressins | 1999 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Antibodies; Autoradiography; Blotting, Western; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Mutant Strains; Motor Neurons; Nerve Degeneration; Neurotoxins; Quinoxalines; Receptors, AMPA; Spinal Cord; Tritium | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heterocyclic Compounds; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Piperidines; Pyrrolidinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dogs; Excitatory Amino Acid Antagonists; Female; Inhalation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; N-Methylaspartate; Neurons; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
The network-selective actions of quinoxalines on the neurocircuitry operations of the rabbit retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Light; Membrane Potentials; Nerve Net; Quinoxalines; Rabbits; Receptors, Glutamate; Retina; Retinal Ganglion Cells; Visual Pathways | 1999 |
Hippocampal theta rhythm in anesthetized rats: role of AMPA glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Electroencephalography; Hippocampus; Male; Physostigmine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Septum Pellucidum; Theta Rhythm | 1999 |
Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Domperidone; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Hormone; Kainic Acid; Luteinizing Hormone; Male; Ovariectomy; Pituitary Gland, Anterior; Prolactin; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine; Sexual Maturation | 1999 |
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreading Depression; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Disease Susceptibility; Dizocilpine Maleate; Enzyme Induction; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Indomethacin; Isoenzymes; Male; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Parietal Lobe; Phospholipases A; Phospholipases A2; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Quinacrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcriptional Activation | 1999 |
Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; GluK2 Kainate Receptor; Glutamates; Hippocampus; Humans; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Tetrazoles | 1999 |
Role of glutamate receptors in transmission of vagal cardiac input to neurones in the nucleus tractus solitarii in dogs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Dogs; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heart; In Vitro Techniques; Microelectrodes; N-Methylaspartate; Neurons; Neurons, Afferent; Quinoxalines; Receptors, Glutamate; Solitary Nucleus; Synaptic Transmission; Vagus Nerve | 1999 |
Excitotoxic effects of non-NMDA receptor agonists in organotypic corticostriatal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kainic Acid; L-Lactate Dehydrogenase; Neocortex; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar | 1999 |
Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androgens; Animals; Brain; Dendrites; Dihydrotestosterone; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Songbirds; Synaptic Transmission; Testosterone; Vocalization, Animal | 1999 |
Long-term effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Autoradiography; Basal Ganglia; Brain Chemistry; Calcinosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Isradipine; Male; Microglia; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nimodipine; Picolinic Acids; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Blood Pressure; Cerebral Cortex; Cerebral Infarction; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Modulators; Heart Rate; Image Processing, Computer-Assisted; Isoflurane; Necrosis; Pentobarbital; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, AMPA | 2000 |
Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Isoxazoles; N-Methylaspartate; Propionates; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Ionotropic glutamate receptor-mediated responses in the rat primary somatosensory cortex evoked by noxious and innocuous cutaneous stimulation in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Hot Temperature; Male; N-Methylaspartate; Neurons; Pain; Piperazines; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, Glutamate; Skin; Somatosensory Cortex; Synapses; Time Factors | 2000 |
Impulsivity and AMPA receptors: aniracetam ameliorates impulsive behavior induced by a blockade of AMPA receptors in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Impulsive Behavior; Male; Motor Activity; Nootropic Agents; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 2000 |
Blocking the trigeminal EPSP in rat abducens motoneurons in vivo with the AMPA antagonists NBQX and GYKI 53655.
Topics: Abducens Nerve; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Motor Neurons; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Trigeminal Nerve | 2000 |
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea | 2000 |
Functional role of NMDA autoreceptors in olfactory mitral cells.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoreceptors; Bicuculline; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Neurons, Afferent; Nifedipine; Olfactory Bulb; Patch-Clamp Techniques; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2000 |
Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Suckling; Benzothiadiazines; Dizocilpine Maleate; Drug Administration Routes; Excitatory Amino Acid Antagonists; Female; Hypothyroidism; Inferior Colliculi; Injections, Intraventricular; Male; Maternal Exposure; N-Methylaspartate; Propylthiouracil; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures | 2000 |
(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Frontal Lobe; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Tetrodotoxin; Tritium | 2000 |
A high GluR1 : GluR2 expression ratio is correlated with expression of Ca2+-binding proteins in rat forebrain neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Biological Transport; Calbindin 1; Calbindins; Calcium; Calcium Channel Blockers; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; In Situ Hybridization; Neurons; Parvalbumins; Prosencephalon; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; S100 Calcium Binding Protein G | 2000 |
Regulation of prolactin secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in male rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Depression, Chemical; Dizocilpine Maleate; Male; Pituitary Gland; Prolactin; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sexual Maturation | 2000 |
Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cerebral Cortex; Corpus Striatum; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Interleukin-1; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2000 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Piperazines; Propionates; Quinoxalines; Rats; Rats, Wistar; Wounds and Injuries | 2000 |
NBQX attenuates excitotoxic injury in developing white matter.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Microinjections; Nerve Fibers, Myelinated; Neuroprotective Agents; Oligodendroglia; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Glutamate | 2000 |
Cross-talk between excitatory and inhibitory amino acids in the regulation of growth hormone secretion in neonatal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Baclofen; Bicuculline; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Muscimol; N-Methylaspartate; Neurosecretory Systems; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2001 |
Dendritic glutamate-induced bursting in prefrontal pyramidal cells: role of NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Glutamic Acid; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: a dual-label microdialysis study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Calcium; Carbon Radioisotopes; Corpus Striatum; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Microdialysis; Nootropic Agents; Potassium; Presynaptic Terminals; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Tritium | 2001 |
In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Death; Dose-Response Relationship, Drug; Electric Stimulation; Female; Lethal Dose 50; Male; Mexiletine; Mice; Neuroprotective Agents; Oxadiazoles; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, AMPA; Sodium Channel Blockers | 2001 |
Characterization of ionotropic glutamate receptors in human lymphocytes.
Topics: 2-Amino-5-phosphonovalerate; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies, Monoclonal; Calcium; CD3 Complex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Lymphocytes; N-Methylaspartate; Phytohemagglutinins; Quinoxalines; Receptors, Glutamate | 2001 |
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar | 2001 |
Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar | 2001 |
Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity.
Topics: Adrenergic alpha-Agonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Carbazoles; Cerebral Cortex; Clonidine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Models, Neurological; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Phenazocine; Prosencephalon; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Scopolamine | 2002 |
Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Concanavalin A; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2002 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Calcium; Cells, Cultured; Cerebral Cortex; Cobalt; Diazoxide; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescence; Fluorometry; Fura-2; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cockroaches; Corpora Allata; Cycloleucine; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Juvenile Hormones; Kainic Acid; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells.
Topics: Adenoviridae; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Brain Neoplasms; Calcium; Cell Movement; Genetic Vectors; Glioblastoma; Humans; Imidazoles; Mice; Mice, Nude; Permeability; Quinoxalines; Receptors, AMPA; Tumor Cells, Cultured | 2002 |
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Glutamic Acid; Kainic Acid; N-Methylaspartate; Osteoblasts; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; Skull | 2002 |
In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Anesthetics, Local; Animals; Antipsychotic Agents; Benzopyrans; Blotting, Western; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Immunohistochemistry; In Situ Hybridization; Indoles; Indophenol; Male; Mice; Mice, Inbred C57BL; Microdialysis; Piperidines; Prazosin; Prefrontal Cortex; Quinoxalines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles; Time Factors | 2003 |
GABA and glutamate receptors are involved in modulating pacemaker activity in hydra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Culture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hydra; Kainic Acid; Quinoxalines; Receptors, GABA; Receptors, Glutamate | 2003 |
Dual roles in feeding for AMPA/kainate receptors: receptor activation or inactivation within distinct hypothalamic regions elicits feeding behavior.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Feeding Behavior; Glutamic Acid; Hypothalamic Area, Lateral; Hypothalamus; Male; Neural Pathways; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Synaptic Transmission | 2003 |
Non-calyceal excitatory inputs mediate low fidelity synaptic transmission in rat auditory brainstem slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Brain Stem; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Synaptic Transmission; Tetrodotoxin; Time Factors; Valine | 2003 |
Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Dizocilpine Maleate; Female; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain Threshold; Propofol; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2004 |
Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzazepines; Brain Chemistry; Corpus Striatum; Drug Administration Schedule; Fungicides, Industrial; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Neuronal Plasticity; Piperazines; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Remoxipride; Substance Withdrawal Syndrome; Time Factors; Triazoles | 2004 |
Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basidiomycota; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Heterocyclic Compounds; Indoles; Injections, Spinal; Japan; Kainic Acid; Lumbosacral Region; Male; Mice; Mice, Inbred Strains; Mushroom Poisoning; Oximes; Pain; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2004 |
Functional topology of the mossy fibre-granule cell--Purkinje cell system revealed by imaging of intrinsic fluorescence in mouse cerebellum.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebellum; Chromones; Diagnostic Imaging; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescence; GABA Antagonists; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred ICR; Nerve Fibers; Neurons; Picrotoxin; Quinoxalines; Time Factors | 2004 |
Activity-dependent maturation of excitatory synaptic connections in solitary neuron cultures of mouse neocortex.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cells, Cultured; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Neocortex; Neurons; Pyridinium Compounds; Quaternary Ammonium Compounds; Quinoxalines; Statistics, Nonparametric; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors; Valine | 2005 |
Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Neuronal Plasticity; Pain, Postoperative; Physical Stimulation; Posterior Horn Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2005 |
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; Gene Expression; Glutamic Acid; Glycine; Hippocampus; Humans; Insecta; Luminescent Proteins; Microscopy, Confocal; Molecular Biology; Mutagenesis, Site-Directed; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Quinoxalines; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors; Transfection | 2005 |
Long-term depression at olfactory nerve synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Diagnostic Imaging; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Sodium Channel Blockers; Sulpiride; Synapses; Tetrodotoxin; Time Factors; Valine | 2005 |
Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Male; Mice; Mice, Inbred C57BL; Quinoxalines | 2005 |
Silent synapses in a thalamo-cortical circuit necessary for song learning in zebra finches.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Finches; In Vitro Techniques; Learning; Lysine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Networks, Computer; Patch-Clamp Techniques; Quinoxalines; Synapses; Thalamus; Vocalization, Animal | 2005 |
Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cannabinoids; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 4; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Membrane Potentials; Methoxyhydroxyphenylglycol; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Quinoxalines; Rats; Synapses | 2005 |
Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Synapses | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley | 2005 |
Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Binding Sites; Brain; Calcium; Cerebellum; Dendrites; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Motor Activity; N-Methylaspartate; Neurons; Polyvinyls; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, AMPA; Sodium; Synapses; Tetrodotoxin; Time Factors | 2005 |
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Carbachol; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Movement; Cells, Cultured; Chelating Agents; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fibronectins; Glutamic Acid; Immunohistochemistry; Immunoprecipitation; Integrin alphaV; Ionophores; Kainic Acid; Models, Biological; Myelin Proteolipid Protein; Myelin Sheath; Oligodendroglia; Pertussis Toxin; Quinoxalines; Rats; Receptor, Platelet-Derived Growth Factor alpha; Receptors, AMPA; Ruthenium Red; Stem Cells; Thapsigargin | 2006 |
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Thymine; Xenopus laevis | 2006 |
Serum-dependence of AMPA receptor-mediated proliferation in glioma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cattle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression; Glioma; Glutamic Acid; Humans; Quinoxalines; Rats; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Serum | 2006 |
Biphasic modulation of GABA release from stellate cells by glutamatergic receptor subtypes.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Morpholines; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinoxalines; Receptors, AMPA | 2007 |
Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Patch-Clamp Techniques; Quinoxalines; Receptors, Nicotinic; Retina; Superior Colliculi; Synapses; Synaptic Transmission; Visual Pathways | 2008 |
Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1).
Topics: Actin Depolymerizing Factors; Actins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biophysics; Cells, Cultured; Dendritic Spines; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Mice; Mice, Knockout; N-Methylaspartate; Neurons; p21-Activated Kinases; Patch-Clamp Techniques; Quinoxalines; Synapses | 2009 |
Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antidepressive Agents; Depressive Disorder; Excitatory Amino Acid Antagonists; Mice; Motor Activity; N-Methylaspartate; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Swimming | 2008 |
Neuroprotective effects of mebudipine and dibudipine on cerebral oxygen-glucose deprivation/reperfusion injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formazans; Glucose; Hypoxia; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Quinoxalines; Receptors, Kainic Acid; Reperfusion Injury; Tetrazolium Salts; Time Factors | 2009 |
Glutamate-vasopressin interactions and the neurobiology of anabolic steroid-induced offensive aggression.
Topics: Age Factors; Aggression; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anabolic Agents; Animals; Animals, Newborn; Arginine Vasopressin; Behavior, Animal; Cricetinae; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hormone Antagonists; Hypothalamic Area, Lateral; Male; Mesocricetus; Microinjections; Quinoxalines; Septal Nuclei; Statistics, Nonparametric; Steroids; Vasopressins; Vesicular Glutamate Transport Protein 2 | 2011 |
A positive feedback synapse from retinal horizontal cells to cone photoreceptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ambystoma; Animals; Calcium; Calcium Signaling; Feedback, Physiological; Glutamic Acid; In Vitro Techniques; Lizards; Membrane Potentials; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Horizontal Cells; Synapses; Zebrafish | 2011 |
What a nostril knows: olfactory nerve-evoked AMPA responses increase while NMDA responses decrease at 24-h post-training for lateralized odor preference memory in neonate rat.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Conditioning, Psychological; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Female; Functional Laterality; In Vitro Techniques; Learning; Male; N-Methylaspartate; Nose; Odorants; Olfactory Bulb; Olfactory Nerve; Olfactory Pathways; Quinoxalines; Rats; Rats, Sprague-Dawley; Smell; Tetrodotoxin | 2012 |
MPTP modulates hippocampal synaptic transmission and activity-dependent synaptic plasticity via dopamine receptors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzazepines; Biophysics; Dopamine Antagonists; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neuronal Plasticity; Neurons; Neurotoxins; Patch-Clamp Techniques; Quinoxalines; Receptors, Dopamine; Sodium Channel Blockers; Sulpiride; Tetrodotoxin; Time Factors; Valine | 2012 |
Muscarinic control of AMPA receptor responsiveness in mouse spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; In Vitro Techniques; Indoles; Mice; Mice, Inbred C57BL; Motor Neurons; Muscarinic Agonists; N-Methylaspartate; Quinoxalines; Receptors, AMPA; Receptors, Muscarinic; Spinal Cord | 2012 |
A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Biophysics; Cell Adhesion Molecules, Neuronal; Cell Line, Transformed; Dendritic Spines; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Green Fluorescent Proteins; Hippocampus; Humans; Long-Term Potentiation; Membrane Proteins; MicroRNAs; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Protein Structure, Tertiary; Quinoxalines; Rats; RNA Interference; Statistics, Nonparametric; Stereotaxic Techniques; Transduction, Genetic; Transfection | 2012 |
Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Depressants; Choice Behavior; Conditioning, Operant; Corpus Striatum; Dopamine Antagonists; Electric Stimulation; Ethanol; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Food Preferences; GABA Antagonists; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Picrotoxin; Quinoxalines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Sucrose; Sulpiride; Sweetening Agents; Synaptosomes; Up-Regulation | 2012 |
Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area Under Curve; Benzothiadiazines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Extracellular Fluid; Fluorometry; Gas Chromatography-Mass Spectrometry; Male; Microdialysis; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Serine; Spermine; Time Factors | 2013 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycogen; Hydrogen-Ion Concentration; Hypoglycemia; Kynurenic Acid; Lactic Acid; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
Glutamate receptors in the nucleus tractus solitarius contribute to ventilatory acclimatization to hypoxia in rat.
Topics: Acclimatization; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chemoreceptor Cells; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hypoxia; Male; N-Methylaspartate; Pulmonary Ventilation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reflex; Solitary Nucleus | 2014 |
Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cell Differentiation; Cell Line; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrophysiology; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Quinoxalines; Receptors, Ionotropic Glutamate | 2014 |
Efficient, complete deletion of synaptic proteins using CRISPR.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cells, Cultured; Clustered Regularly Interspaced Short Palindromic Repeats; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Hippocampus; Humans; In Vitro Techniques; Luminescent Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Red Fluorescent Protein; RNA; Synapses; Synaptophysin | 2014 |
Glutamatergic Receptor Activation in the Commisural Nucleus Tractus Solitarii (cNTS) Mediates Brain Glucose Retention (BGR) Response to Anoxic Carotid Chemoreceptor (CChr) Stimulation in Rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Carotid Body; Glucose; Hypoxia; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Solitary Nucleus | 2015 |
The role of the AMPA receptor and 5-HT(3) receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice.
Topics: Aggression; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Depression; Food Preferences; Glutamate Decarboxylase; Hypothalamus; Injections, Intraperitoneal; Male; Mice; Microinjections; Motor Activity; Neurons; Ondansetron; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, Serotonin, 5-HT3; Social Isolation | 2016 |
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Topics: 14-3-3 Proteins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Endosomal Sorting Complexes Required for Transport; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; HEK293 Cells; Humans; Lysine; Male; Mice, Knockout; Microscopy, Confocal; Mutation, Missense; Nedd4 Ubiquitin Protein Ligases; Neurons; Quinoxalines; Receptors, AMPA; Seizures; Ubiquitin-Protein Ligases | 2017 |
Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats.
Topics: Affect; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Citalopram; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Limbic Lobe; Male; Neuroglia; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Quinoxalines; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Veratridine | 2017 |
Prefrontal Cortex Drives Distinct Projection Neurons in the Basolateral Amygdala.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Basolateral Nuclear Complex; Channelrhodopsins; Cholera Toxin; Dependovirus; Excitatory Postsynaptic Potentials; Genetic Vectors; Hippocampus; In Vitro Techniques; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2017 |
Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kolliker-Fuse Nucleus; Male; Microinjections; Parabrachial Nucleus; Quinoxalines; Rabbits; Respiratory Center; Respiratory Rate | 2020 |