alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol has been researched along with rimcazole in 16 studies
| Studies (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Trials (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Recent Studies (post-2010) (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Studies (rimcazole) | Trials (rimcazole) | Recent Studies (post-2010) (rimcazole) |
|---|---|---|---|---|---|
| 90 | 1 | 2 | 103 | 2 | 13 |
| Protein | Taxonomy | alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol (IC50) | rimcazole (IC50) |
|---|---|---|---|
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.14 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 1.0235 | |
| Scavenger receptor class B member 1 | Homo sapiens (human) | 1.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.9196 | |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | 1.4152 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 11 (68.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cain, GA; Christos, TE; Cook, L; Drummond, S; Gilligan, PJ; Johnson, AL; Kergaye, AA; McElroy, JF; Rohrbach, KW; Schmidt, WK | 1 |
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Meier, E; Moltzen, EK; Perregaard, J; Sánchez, C | 1 |
| Meier, E; Moltzen, EK; Perregaard, J | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Midgley, LP | 1 |
| Bejanian, M; Bova, MP; George, R; Pechnick, RN | 1 |
| Balestra, B; Candura, SM; Coccini, T; Costa, LG; Iapadre, N; Manzo, L; Tonini, M | 1 |
| Iwamoto, ET | 1 |
| della Puppa, A; London, ED | 1 |
| Cook, L; Steinfels, GF; Tam, SW | 1 |
| Largent, BL; Snyder, SH | 1 |
| Ford-Rice, FY; London, ED; Schell, SE; Su, TP | 1 |
| Sonsalla, PK; Terleckyj, I | 1 |
| Araki, H; Ogawa, S; Okuyama, S; Otomo, S; Tsuchida, K | 1 |
| Monnet, FP | 1 |
2 review(s) available for alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol and rimcazole
| Article | Year |
|---|---|
Receptor mechanisms in antipsychotic drug action: focus on sigma receptors.
Topics: Antipsychotic Agents; Benzamides; Carbazoles; Carbolines; Drug Design; Female; Humans; Isoquinolines; Male; Piperazines; Pyridines; Pyrimidines; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, sigma; Remoxipride; Schizophrenia; Spiro Compounds | 1989 |
[Involvement of sigma receptors in schizophrenic syndromes. Pathophysiological approach].
Topics: Antipsychotic Agents; Carbazoles; Hippocampus; Humans; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, sigma; Remoxipride; Schizophrenia; Thalamus | 1993 |
14 other study(ies) available for alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol and rimcazole
| Article | Year |
|---|---|
Novel piperidine sigma receptor ligands as potential antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Piperidines; Rats; Receptors, Serotonin; Receptors, sigma; Structure-Activity Relationship | 1992 |
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
Topics: Animals; Binding Sites; Indoles; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship | 1995 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines.
Topics: Animals; Benzofurans; Benzopyrans; Binding Sites; Binding, Competitive; Brain; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship | 1995 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
Characterization of phencyclidine-induced effects on neuropeptide Y systems in the rat caudate-putamen.
Topics: 4-Aminobutyrate Transaminase; Adrenergic beta-Antagonists; Aminocaproates; Aminooxyacetic Acid; Animals; Benzazepines; Carbazoles; Corpus Striatum; Dioxanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Idazoxan; Male; Naloxone; Neuropeptide Y; Phencyclidine; Prazosin; Psychotropic Drugs; Putamen; Pyrimidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors; Vigabatrin | 1992 |
Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Body Temperature; Carbazoles; Drug Interactions; Guanidines; Injections, Intraventricular; Injections, Subcutaneous; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1991 |
Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Carbazoles; Dextromethorphan; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Parasympathetic Nervous System; Phenazocine; Pyrimidines; Receptors, Opioid; Receptors, sigma | 1991 |
Evidence for a model of activation of central sigma systems.
Topics: Animals; Benzazepines; Benzomorphans; Butaclamol; Carbazoles; Dopamine Antagonists; Haloperidol; Kinetics; Male; Models, Biological; Motor Activity; Naltrexone; Narcotic Antagonists; Phenazocine; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Sulpiride | 1989 |
Cerebral metabolic effects of sigma ligands in the rat.
Topics: Animals; Autoradiography; Blood Pressure; Brain; Carbazoles; Deoxyglucose; Heart Rate; Male; Pentazocine; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, sigma | 1989 |
Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbazoles; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dopamine Agents; Male; Neurons; Pentazocine; Phencyclidine; Piperidines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Substantia Nigra | 1989 |
Correlation of inhibitory potencies of putative antagonists for sigma receptors in brain and spleen.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Carbazoles; Guinea Pigs; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Phenazocine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, sigma; Spleen; Tritium | 1988 |
The sigma receptor ligand (+/-)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain Diseases; Butaclamol; Carbazoles; Dizocilpine Maleate; Dopamine; Dopamine Agents; Drug Interactions; Drug Synergism; Guanidines; Ligands; Male; Methamphetamine; Mice; MPTP Poisoning; Neostriatum; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, Dopamine; Receptors, sigma; Stereoisomerism; Tyrosine 3-Monooxygenase | 1994 |
The sigma-selective ligand NE-100 attenuates the effect of phencyclidine in a rat diving model.
Topics: Animals; Anisoles; Carbazoles; Diving; Male; Motor Activity; Phencyclidine; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma | 1995 |