alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol has been researched along with haloperidol in 29 studies
| Studies (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Trials (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Recent Studies (post-2010) (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) | Studies (haloperidol) | Trials (haloperidol) | Recent Studies (post-2010) (haloperidol) |
|---|---|---|---|---|---|
| 90 | 1 | 2 | 20,330 | 1,753 | 3,294 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.79) | 18.7374 |
| 1990's | 22 (75.86) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernstein, E; Dextraze, P; Eison, MS; Lobeck, WG; New, JS; Taylor, DP; Temple, DL; Yevich, JP; Yocca, FD | 1 |
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Meier, E; Moltzen, EK; Perregaard, J; Sánchez, C | 1 |
| Meier, E; Moltzen, EK; Perregaard, J | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Chaki, S; Hatayama, K; Kawashima, Y; Nakazato, A; Ohta, K; Okuyama, S; Sekiguchi, Y | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Maier, CA; Wünsch, B | 2 |
| Bedürftig, S; Wünsch, B | 1 |
| Hudzik, TJ | 1 |
| Ciancone, MT; Haracz, JL; Rebec, GV; White, IM | 1 |
| de Montigny, C; Debonnel, G; Fournier, A; Monnet, FP | 1 |
| Levant, B; Nemeroff, CB | 1 |
| Borosky, SA; Clissold, DB; Ferkany, JW; Goode, S; Karbon, EW; Patch, RJ; Pontecorvo, MJ | 1 |
| Balestra, B; Candura, SM; Coccini, T; Costa, LG; Iapadre, N; Manzo, L; Tonini, M | 1 |
| Iwamoto, ET | 1 |
| Blair, D; Matthews, RT; McMillen, BA; Sallis, R | 1 |
| Wachtel, SR; White, FJ | 1 |
| Ford-Rice, FY; London, ED; Schell, SE; Su, TP | 1 |
| Maurice, T; Nabeshima, T; Parish, DW; Privat, A; Su, TP | 1 |
| Akunne, H; Caprathe, BW; Jaen, JC; Pugsley, TA; Wise, LD | 1 |
| De Costa, BR; Hudzik, TJ; McMillan, DE | 1 |
| Chaki, S; Imagawa, Y; Muramatsu, M; Okuyama, S; Otomo, S; Tanaka, M | 1 |
| Bergeron, R; De Montigny, C; Debonnel, G | 1 |
| Barfknecht, CF; Schoenwald, RD; Shirolkar, S; Xia, E | 1 |
| Akiyama, K; Kuroda, S; Okumura, K; Ujike, H | 1 |
| Junien, JL; Maurice, T; Privat, A | 1 |
| Chariot, J; Fu-Cheng, X; Rozé, C; Souli, A | 1 |
29 other study(ies) available for alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol and haloperidol
| Article | Year |
|---|---|
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Molecular Structure; Piperazines; Pyrimidines; Rats; Receptors, Dopamine D2; Stereoisomerism; Stereotyped Behavior | 1992 |
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
Topics: Animals; Binding Sites; Indoles; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship | 1995 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines.
Topics: Animals; Benzofurans; Benzopyrans; Binding Sites; Binding, Competitive; Brain; Male; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Sensitivity and Specificity; Structure-Activity Relationship | 1995 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs.
Topics: Animals; Anisoles; Antipsychotic Agents; Brain; Drug Design; Drug Evaluation, Preclinical; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Propylamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Stereotyped Behavior; Structure-Activity Relationship | 1999 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.
Topics: Acetals; Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Ligands; Liver; Piperidines; Pyrones; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Structure-Activity Relationship | 2002 |
Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.
Topics: Animals; Benzopyrans; Brain; Guinea Pigs; In Vitro Techniques; Ligands; Piperidines; Radioligand Assay; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship | 2002 |
1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity.
Topics: Azepines; Piperazine; Piperazines; Protein Binding; Receptors, sigma; Structure-Activity Relationship | 2009 |
Sigma ligand-induced emesis in the pigeon.
Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting | 1992 |
A lever-release version of the conditioned avoidance response paradigm: effects of haloperidol, clozapine, sulpiride, and BMY-14802.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Male; Psychotropic Drugs; Pyrimidines; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulpiride | 1992 |
Neuropeptide Y potentiates the N-methyl-D-aspartate response in the CA3 dorsal hippocampus. II. Involvement of a subtype of sigma receptor.
Topics: Animals; Cinnamates; Cyclopropanes; Drug Synergism; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Neuropeptide Y; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Receptors, sigma; Spiperone | 1992 |
Further studies on the modulation of regional brain neurotensin concentrations by antipsychotic drugs: focus on haloperidol and BMY 14802.
Topics: Animals; Benzazepines; Brain; Drug Interactions; Haloperidol; Injections, Intraperitoneal; Male; Neurotensin; Psychotropic Drugs; Pyrimidines; Rats; Rats, Inbred Strains; Sulpiride | 1992 |
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nimodipine; Piperidines; Postural Balance; Pyrimidines; Receptors, Opioid; Receptors, sigma; Seizures | 1991 |
Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Carbazoles; Dextromethorphan; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Parasympathetic Nervous System; Phenazocine; Pyrimidines; Receptors, Opioid; Receptors, sigma | 1991 |
Evidence for a model of activation of central sigma systems.
Topics: Animals; Benzazepines; Benzomorphans; Butaclamol; Carbazoles; Dopamine Antagonists; Haloperidol; Kinetics; Male; Models, Biological; Motor Activity; Naltrexone; Narcotic Antagonists; Phenazocine; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Sulpiride | 1989 |
Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Brain; Buspirone; Dopamine; Female; Haloperidol; Neurons; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tyrosine 3-Monooxygenase | 1986 |
Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Clozapine; Dopamine; Electrophysiology; Haloperidol; Male; Neurons; Pyrimidines; Rats; Rats, Inbred Strains | 1988 |
Correlation of inhibitory potencies of putative antagonists for sigma receptors in brain and spleen.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Carbazoles; Guinea Pigs; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Phenazocine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, sigma; Spleen; Tritium | 1988 |
PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Avoidance Learning; Cholinergic Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Learning; Male; Maze Learning; Memory; Memory, Short-Term; Mice; Morpholines; Phencyclidine; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma | 1994 |
Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Brain; Butanols; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; Guinea Pigs; Haloperidol; Homovanillic Acid; Humans; Male; Oxidation-Reduction; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, sigma; Stereoisomerism | 1993 |
Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.
Topics: Animals; Anti-Anxiety Agents; Antiemetics; Binding Sites; Columbidae; Drug Interactions; Emetics; Guanidines; Haloperidol; Male; Pyrimidines; Receptors, sigma; Vomiting | 1993 |
FH-510, a potent and selective ligand for rat brain sigma recognition sites.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Carbazoles; Dopamine; Haloperidol; Male; Mice; Phenazocine; Phencyclidine; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma; Stereotyped Behavior | 1993 |
Modification of the N-methyl-D-aspartate response by antidepressant sigma receptor ligands.
Topics: 1-Naphthylamine; Animals; Antidepressive Agents; Clorgyline; Electrophysiology; Haloperidol; Male; N-Methylaspartate; Paroxetine; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sertraline; Tranylcypromine | 1993 |
The effects of sigma ligands on protein release from lacrimal acinar cells: a potential agonist/antagonist assay.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Eye Proteins; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Pentazocine; Phenethylamines; Pyrimidines; Rabbits; Receptors, sigma | 1995 |
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.
Topics: Animals; Antipsychotic Agents; Dibenzothiepins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dystonia; Guanidines; Haloperidol; Male; Microinjections; Nerve Tissue Proteins; Perphenazine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Red Nucleus; Sulpiride; Torticollis | 1996 |
Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Injections, Subcutaneous; Learning Disabilities; Ligands; Male; Memory Disorders; Mice; Pyrimidines; Receptors, sigma | 1997 |
Antisecretory effect of peptide YY through neural receptors in the rat jejunum in vitro.
Topics: Animals; Atropine; Haloperidol; Hexamethonium; Idazoxan; In Vitro Techniques; Jejunum; Male; Peptide YY; Pyrimidines; Rats; Rats, Wistar; Tetrodotoxin | 1999 |