Page last updated: 2024-09-02

alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol and dextromethorphan

alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol has been researched along with dextromethorphan in 4 studies

Compound Research Comparison

Studies
(alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol)
Trials
(alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol)
Recent Studies (post-2010)
(alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol)
Studies
(dextromethorphan)
Trials
(dextromethorphan)
Recent Studies (post-2010) (dextromethorphan)
90122,020342593

Protein Interaction Comparison

ProteinTaxonomyalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol (IC50)dextromethorphan (IC50)
Sodium channel protein type 1 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 3 subunit alphaRattus norvegicus (Norway rat)1.3
Cytochrome P450 2D26Rattus norvegicus (Norway rat)5.6
Cytochrome P450 2D6Homo sapiens (human)2.1768
Sodium-dependent serotonin transporterHomo sapiens (human)0.0027
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.1236

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hudzik, TJ1
Balestra, B; Candura, SM; Coccini, T; Costa, LG; Iapadre, N; Manzo, L; Tonini, M1
Kamei, H; Kameyama, T; Nabeshima, T1
Berger, SP; Brudney, EG; Johnson, SW; Meshul, CK; Paquette, MA; Putterman, DB1

Other Studies

4 other study(ies) available for alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol and dextromethorphan

ArticleYear
Sigma ligand-induced emesis in the pigeon.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting

1992
Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons.
    European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Carbazoles; Dextromethorphan; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Parasympathetic Nervous System; Phenazocine; Pyrimidines; Receptors, Opioid; Receptors, sigma

1991
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites.
    European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Phenazocine; Phencyclidine; Phenytoin; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stress, Physiological

1996
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
    Neuroreport, 2008, Jan-08, Volume: 19, Issue:1

    Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Levodopa; Ligands; Male; N-Methylaspartate; Neurotoxicity Syndromes; Oxidopamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors

2008