alpha(-(cyclopropylcarbonyl)-2-(methyvlsulfonyl)-beta-oxo-4-(trifluromethyl)benzenepropanenitrile) has been researched along with nitisinone* in 1 studies
1 review(s) available for alpha(-(cyclopropylcarbonyl)-2-(methyvlsulfonyl)-beta-oxo-4-(trifluromethyl)benzenepropanenitrile) and nitisinone
| Article | Year |
|---|---|
4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target.
The molecular mechanism for 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibition by nitisinone, a recently approved new drug for the treatment of hereditary tyrosinemia type I, has been satisfactorily explained by its action as an analogue to the substrate 4-hydroxyphenylpyruvate. In addition, a novel induced conformationally restricted 4-HPPD inhibitor, diketonitrile, which serves as a nonclassical bioisostere for rigid cyclic 1,3-diketone derivatives, has been introduced. Further application of the molecular mode of action of nitisinone in rational design of potential inhibitors for alpha-ketoglutarate-coupled dioxygenases is discussed. Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Cyclohexanones; Drug Design; Enzyme Inhibitors; Forecasting; Isoxazoles; Molecular Structure; Nitriles; Nitrobenzoates; Oxygenases; Sulfones; Tyrosinemias | 2003 |