aloxistatin and leucine
aloxistatin has been researched along with leucine in 126 studies
Research
Studies (126)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (7.94) | 18.7374 |
| 1990's | 30 (23.81) | 18.2507 |
| 2000's | 57 (45.24) | 29.6817 |
| 2010's | 28 (22.22) | 24.3611 |
| 2020's | 1 (0.79) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Buttle, DJ; Saklatvala, J | 1 |
| Satoyoshi, E | 1 |
| Kumar, A; Shafiq, S; Stracher, A; Wadgaonkar, R | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J; Tamai, M | 1 |
| Hayashi, M; Inomata, M; Ito, H; Kawashima, S; Saito, Y | 1 |
| Fukushima, K; Kohno, Y; Osabe, W; Satoh, T; Suwa, T | 1 |
| Arai, M; Fukushima, K; Murata, M; Satoh, T; Suwa, T; Tamai, M; Yokoo, C | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y; Sadowska, K; Wheeler-Jones, CP | 1 |
| Chao, WF; Kai, M; Ohkura, Y | 1 |
| Fujii, J; Hiraishi, S; Ishii, H; Kazama, M; Kuboki, M | 1 |
| Arai, M; Fukushima, K; Kohno, Y; Satoh, T; Suwa, T | 1 |
| Becker, E; Detwiler, TC; McGowan, EB | 1 |
| Arai, M; Fukushima, K; Ogawa, H; Satoh, T; Suwa, T | 1 |
| Kajiwara, Y; Kambayashi, J; Mori, T; Sakon, M; Tsujinaka, T | 1 |
| Hanada, K; Koyama, I; Matsumoto, K; Omura, S; Ozawa, Y; Tamai, M | 1 |
| Ahsan, A; Bain, DL; Ostrowski, LE; Pagast, P; Patel, A; Schultz, RM; Suthar, BP; Wong, C | 1 |
| Kanaoka, Y; Murata, M; Oguma, K; Sato, E; Sota, K; Tamai, M; Yokoo, C | 1 |
| Hanada, K; Kimura, M; Omura, S; Sugita, H; Tamai, M | 1 |
| Hiraguchi, M; Mashino, K; Takatsu, M; Terao, T | 1 |
| Sano, M | 1 |
| Hosoya, J; Inazuki, K; Komatsu, K; Satoh, S | 1 |
| Brindley, DN; Hobman, TC; Wang, CN | 1 |
| Beatini, N; Maxfield, FR; Schissel, SL; Tabas, I; Zha, X | 1 |
| Hook, VY; Kannan, R; Krieger, TJ; Mende-Mueller, L; Noctor, S; Tezapsidis, N | 1 |
| Kater, SB; Malmstrom, T; Mykles, DL; Song, DK | 1 |
| Kobayashi, Y; Watanabe, N | 1 |
| Lee, DB; Murray, EJ; Murray, SS; Tram, KK | 1 |
| Ariyoshi, H; Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Yoshida, K | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J | 1 |
| Fernandez, C; Sainz, RD | 1 |
| Bentley, GV; Grisanti, MS; Murray, EJ; Murray, SS | 1 |
| Cui, SH; Ito, M; Tanabe, F | 2 |
| Everts, V | 1 |
| Fagard, R; Lijnen, P; Petrov, V | 1 |
| Beertsen, W; Buttle, DJ; Creemers, LB; Everts, V; Hoeben, KA; Jansen, DC | 1 |
| Du, X; Meredith, J; Mu, Z; Saido, T | 1 |
| Otani, T | 1 |
| Baker, SC; Kanjanahaluethai, A; Lai, MM; Oh, JW; Schiller, JJ; Shi, ST | 1 |
| de Groot, C; van Eijk, M | 1 |
| Barbato, C; Calissano, P; Canu, N; Ciotti, MT; Dus, L; Serafino, A | 1 |
| Hasegawa, H; Iida, Y; Ikeda, R; Kojima, M; Nakanishi, N; Oguro, K; Sawabe, K; Yamashita, A | 1 |
| Caughey, B; Doh-Ura, K; Iwaki, T | 1 |
| Banik, NL; Hogan, EL; Matzelle, DC; Ray, SK; Wilford, GG | 1 |
| Mizel, SB; Moors, MA | 1 |
| Baker, SC; Kanjanahaluethai, A | 1 |
| Ahram, M; Kirn, D; Linebaugh, B; Qiu, RG; Sameni, M; Sloane, BF | 1 |
| Banik, NL; Hogan, EL; Matzelle, DD; Ray, SK; Wilford, GG | 3 |
| Akiyama, J; Ishisaka, R; Kanno, T; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Albrecht, T; Chen, Z; Knutson, E; Kurosky, A | 1 |
| Ahern, R; Connor, JR; Dodds, RA; Drake, FH; Gowen, M; Holmes, S; Hwang, SM; James, IE; Lark, MW; Rieman, D; Thompson, SD; Veber, DF | 1 |
| Hishita, T; Kawanishi, S; Miura, Y; Nishihara, T; Tada-Oikawa, S; Tohyama, K; Tohyama, Y; Uchiyama, T; Yoshida, Y | 1 |
| Bell, GI; Burant, CF; Cox, NJ; Currie, KP; Fox, AP; Hanis, CL; Hansen, PA; Horikawa, Y; Lee, JP; Ostrega, DM; Otani, K; Pan, CY; Polonsky, KS; Pugh, W; Sreenan, SK; Zhou, YP | 1 |
| Agematsu, K; Cui, SH; Hara, T; Ito, M; Iwata, T; Iwatani, Y; Komiyama, A; Nomura, A; Nunoi, H; Onodera, T; Tanabe, F; Terunuma, H | 1 |
| Fardon, NJ; Thomas, TH; Wilkinson, R | 1 |
| Currier, PF; Denison, MR; Kim, JC; Lu, X; Spence, RA | 1 |
| Abé, S; Fujimoto, K; Kitano, T; Yamamoto, T | 1 |
| Ishisaka, R; Utsumi, K; Utsumi, T | 1 |
| Baruch, A; Bogyo, M; Bozdech, Z; DeRisi, J; Engel, J; Grainger, M; Greenbaum, DC; Holder, AA; Medzihradszky, KF | 1 |
| Hosoyama, Y; Miyata, S; Sekiguchi, T | 1 |
| Allen, DA; Chesser, AM; Harwood, SM; New, DI; Raftery, MJ; Yaqoob, MM | 1 |
| Ahmed, N; Baldwin, AC; Bell, GI; Bindokas, VP; Cox, NJ; Currie, KP; Fox, AP; Horikawa, Y; Lee, JP; Miller, RJ; Ostrega, D; Pan, CY; Polonsky, KS; Sreenan, S; Zhou, YP | 1 |
| Bérubé, G; Hebert, S; Nepvue, A | 1 |
| Eggo, MC; Langman, MJ; Lewis, AE; Wong, BC | 1 |
| Hattori, M; Jauh, GY; Moriyasu, Y; Rogers, JC | 1 |
| Mlinaric-Rascan, I; Turk, B | 1 |
| Banik, NL; Guyton, MK; Matzelle, DD; Ray, SK; Sribnick, EA; Wingrave, JM | 1 |
| Behrendt, N; Bugge, TH; Danø, K; Engelholm, LH; Høyer-Hansen, M; Kjøller, L | 1 |
| Bruchhaus, I; Lotter, H; Nowak, N; Tannich, E | 1 |
| Brunk, UT; Hillman, J; Li, W; Yu, Z | 1 |
| Fuji, K; Hara-Nishimura, I; Nishimura, M; Shimada, T; Yamada, K | 1 |
| Hall, AM; Orlow, SJ | 1 |
| Concha, C; Even, Y; Genevière, AM; Imschenetzky, M; Monardes, A; Morin, V; Puchi, M | 1 |
| Gajkowska, B; Lamparska-Przybysz, M; Motyl, T | 1 |
| Fujii, T; Itoh, M; Kawabata, D; Maruyama, H; Mimori, T; Tanaka, M; Umehara, H; Yoshifuji, H | 1 |
| Diaz de Villalvilla, AP; Gorelick, FS; Kolodecik, TR; Thrower, EC | 1 |
| Dennhöfer, R; Hunzelmann, N; Klose, A; Mauch, C; Zigrino, P | 1 |
| Cahill, J; Solaroglu, I; Tsubokawa, T; Yata, K; Yatsushige, H; Zhang, JH | 1 |
| Fujita, E; Isoai, A; Kaufman, RJ; Kominami, E; Kouroku, Y; Kumagai, H; Momoi, T; Ogawa, S; Tanida, I; Ueno, T | 1 |
| Calvert, JW; Shimamura, N; Solaroglu, I; Tsubokawa, T; Yamaguchi-Okada, M; Yata, K; Zhang, JH | 1 |
| Kominami, E; Minematsu-Ikeguchi, N; Tanida, I; Ueno, T | 1 |
| Alain, T; Forsyth, PA; Johnston, RN; Kim, M; Kossakowska, AE; Lee, PW; Urbanski, S | 1 |
| Czesny, B; Eksi, S; Eling, W; Sauerwein, RW; van Gemert, GJ; Williamson, KC | 1 |
| Hook, G; Hook, V; Kindy, M | 2 |
| Ito, M; Kasai, H; Morimoto, M; Tanabe, F | 1 |
| Alhassan, A; Govind, Y; Igarashi, I; Okubo, K; Yokoyama, N | 1 |
| Albritton, LM; Fields, C; Franks, J; Kumar, P; Nachagari, D | 1 |
| Banik, NL; Matzelle, DD; Ray, SK; Sribnick, EA | 1 |
| Guggino, WB; Kwon, SH; Pollard, H | 1 |
| Hook, G; Hook, VY; Kindy, M | 1 |
| Cheng, XW; Izawa, H; Kim, W; Kobayashi, M; Kuzuya, M; Murohara, T; Nagata, K; Nishizawa, T; Obata, K; Okumura, K; Sasaki, T; Sato, K; Shi, GP; Yamada, T; Yokota, M | 1 |
| Arancio, O; Fa', M; Hidalgo, A; Liu, S; Mathews, PM; Nixon, RA; Schmidt, SD; Trinchese, F; Yamaguchi, H; Yoshii, N; Zhang, H | 1 |
| Arnone, M; Engels, B; Fink, RF; Mladenovic, M | 1 |
| Hirotsune, S; Kengaku, M; Miyakawa, T; Mori, D; Sato, M; Sorimachi, H; Takao, K; Takitoh, T; Umeshima, H; Wynshaw-Boris, A; Yamada, M; Yoshida, Y | 1 |
| Craig, MJ; Pienta, KJ; Roca, H; Sud, S; Varsos, ZS; Ying, C | 1 |
| Borner, C; Buellesbach, J; Ekert, PG; Huai, J; Oberle, C; Rassner, M; Reinheckel, T; Tacke, M | 1 |
| Hoves, S; Konjar, S; Kopitar-Jerala, N; Peters, C; Reinheckel, T; Repnik, U; Sutton, VR; Trapani, JA; Turk, B; Turk, V; Yagita, H | 1 |
| Caruso, J; Kessel, D; Price, M; Reiners, J | 1 |
| Kern, S; Kuehn, A; Pradel, G; Przyborski, J; Schillig, R; Sologub, L | 1 |
| Beck, A; Boehm, BO; Brücken, R; Burster, T; Kalbacher, H; Palesch, D; Schäfer, N; Sienczyk, M; Sun, Z; Zou, F | 1 |
| Ji, WJ; Liang, ZQ; Long, LM; Zhuang, WZ | 1 |
| Inoue, Y; Moriyasu, Y; Oh-ye, Y | 1 |
| Ishiguro, S; Nakazawa, M; Ozaki, T; Sato, K | 1 |
| Cramer, SJ; Dautzenberg, IJ; de Groot, RJ; Hoeben, RC; van den Hengel, SK; van den Wollenberg, DJ | 1 |
| Chen, Y; Detmar, M; Liersch, R | 1 |
| Prasad, R; Puri, SK; Sijwali, PS; Soni, A | 1 |
| García-Arrarás, JE; González, S; Ortiz, S; Pasten, C; Rosa, R | 1 |
| Alves, S; Chaves, SR; Côrte-Real, M; Coutinho, OP; Marques, C; Oliveira, CS; Preto, A | 1 |
| Ahmad, H; Alam, SM; Chou, YW; Kumar, S; Lin, MF; Muniyan, S; Zhang, L | 1 |
| Blum, G; Bogyo, M; Moin, K; Mullins, SR; Sameni, M; Sloane, BF | 1 |
| Hiradate, Y; Hoshino, Y; Lee, S; Sato, E; Tanemura, K | 1 |
| Bitu, CC; Bufalino, A; Coletta, RD; Kauppila, JH; Keinänen, M; Lehenkari, P; Nurmenniemi, S; Nyberg, P; Salo, T; Teppo, S; Vilen, ST | 1 |
| Bayer, KU; Coultrap, SJ; Kulbe, JR; Mulcahy Levy, JM; Thorburn, A | 1 |
| Hook, G; Hook, V; Kindy, M; Toneff, T; Yu, J | 1 |
| Cheng, J; Duan, S; Jiang, K; Li, C; Wang, Y; Wu, Y; Xu, J; Yu, L; Zhang, X | 1 |
| Batinovic, S; Charman, S; Chiu, F; Crespo, MP; Dogovski, C; Hanssen, E; Klonis, N; Stafford, C; Teguh, S; Tilley, L; Xie, SC; Yang, T | 1 |
| Guo, K; Jiang, D; Li, S; Liang, D; Wang, H; Xiao, J; Yang, X; Zhang, X | 1 |
| Chen, L; Chen, M; Meng, Y; Qi, G; Ren, L; Shi, L; Wu, Q; Yu, B | 1 |
| Creighton, CJ; Fradette, JJ; Gibbons, DL; Gibson, LA; Grzeskowiak, CL; Kundu, ST; Rodriguez, LB; Scott, KL | 1 |
| Chen, X; Ge, H; Gong, X; Hameed, MF; Wang, J; Zhang, N; Zhang, W; Zhao, X | 1 |
| Bidovec, K; Božič, J; Dolenc, I; Stoka, V; Vizovišek, M | 1 |
| Li, XJ; Ma, L; Mou, Y; Tian, Y; Trinh, J; Wang, Y; Xu, C; Zhang, B; Zhang, X; Zhou, S | 1 |
| de Barros, ALB; de Jesus, MB; de Oliveira Silva, J; Dos Reis, SB; Garcia-Fossa, F; Leite, EA; Malachias, A; Mosqueira, VCF; Oliveira, MC; Pound-Lana, G | 1 |
Reviews
1 review(s) available for aloxistatin and leucine
| Article | Year |
|---|---|
Therapeutic trials on progressive muscular dystrophy.
Topics: Animals; Child; Child, Preschool; Cricetinae; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Incidence; Japan; Leucine; Life Expectancy; Male; Mice; Muscular Dystrophies; Muscular Dystrophy, Animal; Prevalence; Protease Inhibitors; Single-Blind Method | 1992 |
Trials
1 trial(s) available for aloxistatin and leucine
| Article | Year |
|---|---|
Therapeutic trials on progressive muscular dystrophy.
Topics: Animals; Child; Child, Preschool; Cricetinae; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Incidence; Japan; Leucine; Life Expectancy; Male; Mice; Muscular Dystrophies; Muscular Dystrophy, Animal; Prevalence; Protease Inhibitors; Single-Blind Method | 1992 |
Other Studies
125 other study(ies) available for aloxistatin and leucine
| Article | Year |
|---|---|
Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation.
Topics: Animals; Cartilage; Cathepsin B; Cattle; Culture Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Dipeptides; Enzyme Activation; Interleukin-1; Kinetics; Leucine; Lysosomes; Proteoglycans; Stimulation, Chemical | 1992 |
The effect of protease inhibitors, leupeptin and E64d, on differentiation of C2C12 myoblasts in tissue culture.
Topics: Animals; Calcium; Calpain; Cell Differentiation; Cell Fusion; Culture Techniques; Leucine; Leupeptins; Mice; Muscles; Protease Inhibitors | 1992 |
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.
Topics: Animals; Cartilage; Cattle; Cysteine Proteinase Inhibitors; Interleukin-1; Iodoacetates; Iodoacetic Acid; Leucine; Proteoglycans; Recombinant Proteins | 1992 |
Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Proteins; Calcimycin; Calcium; Calpain; Enzyme Activation; Erythrocytes; Female; In Vitro Techniques; Leucine; Leupeptins; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits | 1991 |
The disposition of loxistatin and metabolites in normal and dystrophic hamsters.
Topics: Animals; Cricetinae; Cysteine Proteinase Inhibitors; Leucine; Male; Mesocricetus; Muscles; Muscular Dystrophy, Animal; Myocardium; Tissue Distribution | 1991 |
Metabolic fate of loxistatin in rat.
Topics: Administration, Oral; Animals; Cysteine Proteinase Inhibitors; Leucine; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Papain; Prodrugs; Rats; Rats, Inbred Strains | 1990 |
Effects of the calpain inhibitor E64-d on platelet activation responses.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Calpain; Collagen; Humans; In Vitro Techniques; Leucine; Phosphatidic Acids; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
High-performance liquid chromatographic determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by pre-column fluorescence derivatization.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Fluorescent Dyes; Leucine; Mice; Mice, Inbred C57BL; Muscles; Spectrophotometry | 1990 |
Thiolprotease inhibitor, EST, can inhibit thrombin-induced platelet activation.
Topics: Adult; Blood Platelets; Calpain; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Inositol Phosphates; Leucine; Phosphatidylinositols; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Serotonin; Thrombin; Type C Phospholipases | 1990 |
An epoxysuccinic acid derivative(loxistatin)-induced hepatic injury in rats and hamsters.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteamine; Cysteine Proteinase Inhibitors; Drug Interactions; Glutathione; In Vitro Techniques; Leucine; Liver Diseases; Male; Maleates; Mesocricetus; Necrosis; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution | 1990 |
Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d.
Topics: Blood Platelets; Calcimycin; Calpain; Cell Membrane Permeability; Cytoskeletal Proteins; Leucine; Microfilament Proteins; Protease Inhibitors; Talin | 1989 |
Identification of glutathione conjugate formed from loxistatin in rats.
Topics: Administration, Oral; Animals; Bile; Glutathione; In Vitro Techniques; Leucine; Liver; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Studies on myosin light chain phosphorylation in intact platelets, utilizing a cell-penetrating thiol protease inhibitor.
Topics: Blood Platelets; Calcium; Calpain; Humans; In Vitro Techniques; Leucine; Myosin-Light-Chain Kinase; Myosins; Phosphorylation | 1988 |
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
Topics: Animals; Calpain; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Intestinal Absorption; Leucine; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.
Topics: Animals; Cathepsin B; Cathepsins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endopeptidases; Female; Fibrinolysis; Leucine; Leupeptins; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Peptide Hydrolases; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors; Serine Endopeptidases; Thrombin; Thrombosis | 1986 |
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases.
Topics: Chemical Phenomena; Chemistry; Cysteine Endopeptidases; Endopeptidases; Leucine; Muscular Dystrophies; Protease Inhibitors | 1987 |
Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistation (EST).
Topics: Animals; Circadian Rhythm; Cricetinae; Diet; Dose-Response Relationship, Drug; Female; Leucine; Male; Muscular Dystrophy, Animal; Serine Proteinase Inhibitors | 1987 |
[Effect of a cysteine protease inhibitor EST on urinary 3-methylhistidine in dystrophic hamsters (BIO 14.6)].
Topics: Animals; Cricetinae; Cysteine Endopeptidases; Endopeptidases; Histidine; Leucine; Male; Methylhistidines; Muscular Dystrophy, Animal; Protease Inhibitors | 1986 |
[Biochemical studies in experimental chloroquine myopathy--preventive effect of E-64-d and physicochemical properties of liver autolysosomes].
Topics: Animals; Cathepsins; Chloroquine; Leucine; Liver; Lysosomes; Male; Muscular Diseases; Rats; Rats, Inbred Strains | 1986 |
Beneficial effect of new thiol protease inhibitors, epoxide derivatives, on dystrophic mice.
Topics: Animals; Body Weight; Creatine Kinase; Leucine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscular Dystrophy, Animal | 1986 |
Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment.
Topics: Animals; Apolipoprotein B-100; Apolipoproteins B; Cells, Cultured; Dexamethasone; Endoplasmic Reticulum; Golgi Apparatus; Leucine; Lipoproteins, VLDL; Liver; Male; Rats; Rats, Sprague-Dawley | 1995 |
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cholesterol Esters; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Esterification; Female; Hydroxycholesterols; Leucine; Leupeptins; Lipoproteins, VLDL; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Sphingomyelin Phosphodiesterase | 1995 |
Stimulation of "prohormone thiol protease" (PTP) and [Met]enkephalin by forskolin. Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP.
Topics: Adrenal Glands; Animals; Cattle; Cells, Cultured; Chromaffin Granules; Colforsin; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enkephalin, Methionine; Enzyme Activation; Hydrolysis; Leucine; Protein Precursors; Protein Processing, Post-Translational | 1995 |
Calpain inhibitors block Ca(2+)-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons.
Topics: Animals; Axons; Calcimycin; Calcium; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dendrites; Dipeptides; Fetus; Hippocampus; Kinetics; Leucine; Neurites; Pyramidal Cells; Rats; Time Factors | 1994 |
Selective release of a processed form of interleukin 1 alpha.
Topics: Calcimycin; Calcium; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Egtazic Acid; Gene Expression; Humans; Interleukin-1; L-Lactate Dehydrogenase; Leucine; Methionine; Molecular Weight; Protein Processing, Post-Translational; Sulfur Radioisotopes; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
PTH-induced osteoblast contraction is mediated by cysteine proteases.
Topics: Animals; Bone Resorption; Calpain; Cell Line; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Mice; Osteoblasts; Parathyroid Hormone | 1993 |
Stimulation of human platelet Ca(2+)-ATPase and Ca2+ restoration by calpain.
Topics: Aspirin; Blood Platelets; Calcimycin; Calcium; Calcium-Transporting ATPases; Calpain; Cell Compartmentation; Dipeptides; Enzyme Activation; Homeostasis; Humans; Intracellular Membranes; Leucine; Multienzyme Complexes; Platelet Activation; Stimulation, Chemical; Thrombin | 1993 |
The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.
Topics: Animals; Cartilage; Cathepsins; Cattle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dinoprostone; Humans; Interleukin-1; Interleukin-6; Leucine; Nasal Septum; Proteoglycans; Signal Transduction | 1993 |
Pathways of protein degradation in L6 myotubes.
Topics: Animals; Cathepsins; Cell Line; Chloroquine; Clenbuterol; Dexamethasone; Endopeptidases; Glucocorticoids; Insulin; Insulin-Like Growth Factor I; Leucine; Lysosomes; Muscle Fibers, Skeletal; Muscle Proteins; Muscles; Myofibrils; Protease Inhibitors; Rats | 1997 |
E64d, a membrane-permeable cysteine protease inhibitor, attenuates the effects of parathyroid hormone on osteoblasts in vitro.
Topics: Alkaline Phosphatase; Animals; Calcium-Binding Proteins; Calpain; Cell Count; Cell Division; Cell Line; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Leucine; Mice; Osteoblasts; Parathyroid Hormone; Rats; Tumor Cells, Cultured | 1997 |
Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Down-Regulation; Isoenzymes; Leucine; Mice; Mice, Inbred C57BL; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Sphingosine | 1998 |
Is cathepsin K truly involved in bone resorption?
Topics: Bone Resorption; Cathepsin K; Cathepsins; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Ketones; Leucine; Osteoclasts | 1998 |
Activation by calcium of erythrocyte Na+/H+ exchange in men.
Topics: Calcium; Calpain; Cysteine Proteinase Inhibitors; Down-Regulation; Erythrocytes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; Ion Transport; Kinetics; Leucine; Male; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1998 |
Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Hydroxyproline; Leucine; Organ Culture Techniques; Periosteum; Phagocytosis; Rabbits; Skull; Substrate Specificity; Vacuoles | 1998 |
Cleavage of the cytoplasmic domain of the integrin beta3 subunit during endothelial cell apoptosis.
Topics: Antigens, CD; Apoptosis; Calpain; Carrier Proteins; Cell Adhesion; Cells, Cultured; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Integrin beta3; Leucine; Microfilament Proteins; Muscle, Smooth, Vascular; Platelet Membrane Glycoproteins; Signal Transduction; Vanadates | 1998 |
Cysteine protease inhibitor, E-64d, prevents in vitro cerulein- induced trypsinogen activation.
Topics: Animals; Cathepsin B; Ceruletide; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Pancreas; Rats; Trypsinogen | 1998 |
Colocalization and membrane association of murine hepatitis virus gene 1 products and De novo-synthesized viral RNA in infected cells.
Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorides; Cysteine Proteinase Inhibitors; DNA-Directed RNA Polymerases; HeLa Cells; Humans; Intracellular Membranes; Leucine; Leupeptins; Mice; Murine hepatitis virus; Rabbits; RNA, Viral; Staining and Labeling; Time Factors; Viral Proteins; Zinc Compounds | 1999 |
Germinal center B cell apoptosis requires both caspase and cathepsin activity.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; B-Lymphocytes; Caspase Inhibitors; Caspases; Cathepsins; Cells, Cultured; Cysteine Proteinase Inhibitors; Dendritic Cells; Endonucleases; Enzyme Activation; Germinal Center; Humans; Leucine; Palatine Tonsil; Signal Transduction | 1999 |
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins | 2000 |
Rapid turnover of tryptophan hydroxylase is driven by proteasomes in RBL2H3 cells, a serotonin producing mast cell line.
Topics: Amino Acid Motifs; Animals; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrolysis; Leucine; Leupeptins; Mast Cells; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Serotonin; Tryptophan Hydroxylase; Tumor Cells, Cultured; Ubiquitins | 2000 |
Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.
Topics: Animals; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Leucine; Lysosomes; Neuroblastoma; PrPSc Proteins; Quinacrine; Tumor Cells, Cultured | 2000 |
Abnormal down-regulation of PKC is responsible for giant granule formation in fibroblasts from CHS (beige) mice--a thiol proteinase inhibitor, E-64-d, prevents giant granule formation in beige fibroblasts.
Topics: Animals; Cathepsin G; Cathepsins; Cells, Cultured; Ceramides; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytoplasmic Granules; Cytosol; Embryo, Mammalian; Fibroblasts; Leucine; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pancreatic Elastase; Protein Kinase C; Serine Endopeptidases; Sphingolipids; Tetradecanoylphorbol Acetate | 2000 |
E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA Primers; Female; Gene Expression; Leucine; Neurofilament Proteins; Nucleosomes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord Injuries | 2000 |
Proteasome-mediated regulation of interleukin-1beta turnover and export in human monocytes.
Topics: Acrylates; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Half-Life; Humans; Interleukin-1; Lactones; Leucine; Leukemia, Monocytic, Acute; Leupeptins; Lipopolysaccharides; Monocytes; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2000 |
Identification of mouse hepatitis virus papain-like proteinase 2 activity.
Topics: Animals; Cell Line; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Leucine; Mice; Murine hepatitis virus; Mutation; Protein Processing, Post-Translational; RNA-Dependent RNA Polymerase; Viral Nonstructural Proteins; Viral Plaque Assay | 2000 |
Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a three-dimensional matrix.
Topics: Animals; Biomarkers; Cathepsin B; Cell Line; Cell Movement; Cysteine Proteinase Inhibitors; Dextrans; Dipeptides; Endocytosis; Enzyme Activation; Gelatin; Humans; Intracellular Membranes; Leucine; Lysosomes; Phagocytosis; Pinocytosis; rac1 GTP-Binding Protein; Rats; Serum Albumin, Bovine | 2000 |
Increased calpain expression is associated with apoptosis in rat spinal cord injury: calpain inhibitor provides neuroprotection.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Gene Expression Regulation, Enzymologic; Leucine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Transcription, Genetic | 2000 |
Activation of caspase-3 by lysosomal cysteine proteases and its role in 2,2'-azobis-(2-amidinopropane)dihydrochloride (AAPH)-induced apoptosis in HL-60 cells.
Topics: Amidines; Apoptosis; Calcium; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Digitonin; Drug Interactions; Enzyme Activation; HL-60 Cells; Humans; Indicators and Reagents; Leucine; Liver; Lysosomes; Mitochondria; Phosphates; Proteins | 2001 |
Degradation of p21cip1 in cells productively infected with human cytomegalovirus.
Topics: Amino Acid Motifs; Calcium-Binding Proteins; Calpain; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cytomegalovirus; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Leucine; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; Time Factors; Ubiquitins | 2001 |
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
Topics: Biochemistry; Bone and Bones; Bone Resorption; Cathepsin K; Cathepsins; Cell Adhesion; Cysteine Proteinase Inhibitors; Giant Cell Tumor of Bone; Humans; Hydrogen-Ion Concentration; Kidney; Leucine; Linear Models; Oligopeptides; Osteoclasts; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Protein Processing, Post-Translational; Substrate Specificity; Tumor Cells, Cultured | 2001 |
Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39.
Topics: Anti-Bacterial Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cathepsin L; Cathepsins; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Etoposide; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Lysosomes; Macrolides; Membrane Potentials; Mitochondria; Myelodysplastic Syndromes; Proton-Translocating ATPases; Vacuolar Proton-Translocating ATPases | 2001 |
Cell death in spinal cord injury (SCI) requires de novo protein synthesis. Calpain inhibitor E-64-d provides neuroprotection in SCI lesion and penumbra.
Topics: Animals; Apoptosis; Calpain; Cell Death; Cycloheximide; Female; Glycoproteins; Leucine; Protease Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2001 |
Calpains play a role in insulin secretion and action.
Topics: Adipocytes; Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Deoxyglucose; Electric Conductivity; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Membranes; Islets of Langerhans; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NADP; Oligopeptides; Osmolar Concentration; Time Factors | 2001 |
A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity.
Topics: Calpain; Cathepsin G; Cathepsins; Cell Line, Transformed; Ceramides; Chediak-Higashi Syndrome; Child; Concanavalin A; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Antagonism; Female; Humans; Leucine; Leukocytes, Mononuclear; Lysosomes; Male; Pancreatic Elastase; Protein Kinase C; Receptor Aggregation; Serine Endopeptidases; Sphingomyelin Phosphodiesterase | 2001 |
Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.
Topics: Adult; Albuminuria; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Blood Vessels; Calpain; Carcinogens; Cell Fusion; Cell Membrane; Cysteine Proteinase Inhibitors; Cytoplasmic Granules; Enzyme Inhibitors; Female; Humans; Hypertension; Indoles; Lectins, C-Type; Leucine; Lipids; Macrophage-1 Antigen; Male; Maleimides; Metabolic Syndrome; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Tetradecanoylphorbol Acetate | 2001 |
Inhibition of calpain-mediated apoptosis by E-64 d-reduced immediate early gene (IEG) expression and reactive astrogliosis in the lesion and penumbra following spinal cord injury in rats.
Topics: Animals; Apoptosis; Astrocytes; Calpain; Carrier Proteins; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Genes, Immediate-Early; Glial Fibrillary Acidic Protein; Gliosis; Leucine; Microfilament Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2001 |
Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d.
Topics: Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Leucine; Mice; Murine hepatitis virus; Protein Processing, Post-Translational; RNA, Viral; Viral Proteins; Virus Replication | 1995 |
Promotion of cathepsin L activity in newt spermatogonial apoptosis induced by prolactin.
Topics: Animals; Apoptosis; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Male; Organ Culture Techniques; Prolactin; Salamandridae; Spermatogonia; Testis; Tissue Extracts | 2002 |
Involvement of lysosomal cysteine proteases in hydrogen peroxide-induced apoptosis in HL-60 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrogen Peroxide; Leucine; Lysosomes; Mitochondria | 2002 |
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Fluorescent Antibody Technique; Hemoglobins; Humans; Leucine; Life Cycle Stages; Organelles; Plasmodium falciparum; Proteomics | 2002 |
Effects of proteasome inhibitor (lactacystin) and cysteine protease inhibitor (E-64-d) on processes of mitosis in Xenopus embryonic cells.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Leucine; Mitosis; Signal Transduction; Xenopus | 2002 |
Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?
Topics: Acrylates; Animals; Calcium-Binding Proteins; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Hypertrophy, Left Ventricular; Leucine; Male; Nephrectomy; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Uremia | 2003 |
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
Topics: Animals; Calcium; Calpain; Cell Separation; Cysteine Proteinase Inhibitors; Dipeptides; Energy Metabolism; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Mice; Mice, Inbred C57BL; Mitochondria; NADP; Oxidation-Reduction | 2003 |
Development of an in vitro assay for the proteolytic processing of the CDP/Cux transcription factor.
Topics: Animals; Cell Extracts; G1 Phase; Homeodomain Proteins; Leucine; Leupeptins; Mice; NIH 3T3 Cells; Nuclear Proteins; Phosphorylation; Protein Processing, Post-Translational; Recombinant Proteins; Repressor Proteins; S Phase | 2003 |
Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3.
Topics: Aged; Alkaloids; Amino Acid Chloromethyl Ketones; Aprotinin; Benzophenanthridines; Benzyl Compounds; Caspase 3; Caspases; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; DNA; DNA Fragmentation; Down-Regulation; Humans; Hydrocarbons, Fluorinated; Leucine; Leupeptins; Male; Pepstatins; Phenanthridines; Protein Kinase C; Pyridines; Tumor Cells, Cultured | 2003 |
Alpha tonoplast intrinsic protein is specifically associated with vacuole membrane involved in an autophagic process.
Topics: Autophagy; Cysteine Proteinase Inhibitors; Fluorescent Dyes; Hordeum; Intracellular Membranes; Leucine; Lysosomes; Membrane Proteins; Plant Proteins; Plant Roots | 2003 |
B cell receptor-mediated nuclear fragmentation proceeds in WEHI 231 cells in the absence of detectable DEVDase and FRase activity.
Topics: Antibodies; Apoptosis; B-Lymphocytes; Caspase Inhibitors; Caspases; Cathepsins; Cell Division; Cysteine Endopeptidases; DNA Fragmentation; Enzyme Activation; Humans; Immunoglobulin M; Leucine; Peptide Hydrolases; Protease Inhibitors; Tumor Cells, Cultured | 2003 |
Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury.
Topics: Animals; Apoptosis; Calpain; DNA Fragmentation; Electrophoresis, Agar Gel; Leucine; Myelin Basic Protein; Myelin Proteolipid Protein; Nucleosomes; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord Injuries; Transcription, Genetic | 2003 |
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antigens, CD; Cells, Cultured; Collagen Type IV; Cysteine Endopeptidases; Enzyme Inhibitors; Fibroblasts; Kinetics; Leucine; Lysosomal Membrane Proteins; Lysosomes; Membrane Glycoproteins; Mice; Mice, Knockout; Rats; Receptors, Cell Surface; Skin; Subcellular Fractions | 2004 |
Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; CHO Cells; Cricetinae; Culture Media; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Entamoeba histolytica; Gerbillinae; Leucine; Liver; Liver Abscess, Amebic; Microscopy, Electron; Mutation; RNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2004 |
Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal.
Topics: Aldehydes; alpha-Tocopherol; Ammonium Chloride; Analysis of Variance; Annexin A5; Apoptosis; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Flow Cytometry; Fluoresceins; Glutathione; Humans; Leucine; Lysosomes; Mitochondria; Necrosis; Neuroblastoma; Pepstatins; Propylamines; Protease Inhibitors; Reactive Oxygen Species; Rhodamines; Time Factors | 2004 |
Endosomal proteases facilitate the fusion of endosomes with vacuoles at the final step of the endocytotic pathway.
Topics: Arabidopsis; Cells, Cultured; Cysteine Proteinase Inhibitors; Endocytosis; Endosomes; Leucine; Membrane Fusion; Nicotiana; Peptide Hydrolases; Plants, Genetically Modified; Pyridinium Compounds; Quaternary Ammonium Compounds; Quinacrine; Sucrose; Vacuoles | 2005 |
Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation.
Topics: Animals; Cell Line; Cysteine Proteinase Inhibitors; Golgi Apparatus; Leucine; Leupeptins; Melanins; Melanocytes; Mice; Monophenol Monooxygenase; Oxidoreductases; Phenylthiourea; Proteasome Inhibitors | 2005 |
Inhibition of cysteine protease activity disturbs DNA replication and prevents mitosis in the early mitotic cell cycles of sea urchin embryos.
Topics: Acrylates; Animals; Calpain; Cathepsins; CDC2 Protein Kinase; Cell Cycle; Cell Nucleus; Cyclin B; Cysteine Proteinase Inhibitors; Cytoplasm; DNA Replication; Embryo, Nonmammalian; Leucine; Mitosis; Sea Urchins; Tissue Distribution | 2005 |
Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1; BH3 Interacting Domain Death Agonist Protein; Breast Neoplasms; Camptothecin; Cathepsin B; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Activation; Female; Humans; Kinetics; Laser Scanning Cytometry; Leucine; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria; Signal Transduction | 2005 |
Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro.
Topics: Animals; Arthritis, Experimental; Calpain; Cell Line; Cytokines; Female; Gene Expression; Leucine; Mice; Mice, Inbred BALB C; RNA, Messenger | 2005 |
Zymogen activation in a reconstituted pancreatic acinar cell system.
Topics: Amylases; Animals; Carboxypeptidase B; Cathepsin B; Chymotrypsinogen; Enzyme Activation; Enzyme Precursors; Leucine; Membrane Proteins; Organelles; Pancreas, Exocrine; Phosphotransferases; Rats; Rats, Sprague-Dawley; Secretory Vesicles; Trypsin; Trypsinogen | 2006 |
Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells.
Topics: Cathepsin B; Cathepsin L; Cathepsins; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis; Humans; Hydrogen-Ion Concentration; Leucine; Lysosomes; Melanoma; Neoplasm Invasiveness; Sodium Dodecyl Sulfate; Substrate Specificity; Tumor Cells, Cultured | 2006 |
Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Calpain; Cathepsin B; Cerebral Hemorrhage; Cysteine Proteinase Inhibitors; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Infarction, Middle Cerebral Artery; Leucine; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Nerve Tissue Proteins; Neuroprotective Agents; Premedication; Rats; Rats, Sprague-Dawley; Reperfusion; Single-Blind Method | 2006 |
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Caspase 12; Cell Death; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Leucine; Lysosomes; Mice; Microtubule-Associated Proteins; Models, Biological; Pepstatins; Peptides; Phosphorylation; Protein Structure, Quaternary; RNA, Messenger; Sirolimus | 2007 |
Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats.
Topics: Analysis of Variance; Animals; Apoptosis; Brain Edema; Brain Infarction; Brain Ischemia; Calpain; Caspase 3; Caspases; Cathepsins; Endothelium, Vascular; Functional Laterality; Gene Expression; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Leucine; Male; Neurologic Examination; Neurons; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tetrazolium Salts | 2006 |
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy.
Topics: Autophagy; Biological Transport, Active; Biomarkers; Cell Line; Humans; Hydrolases; Leucine; Lysosomes; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Pepstatins; Phagosomes | 2005 |
The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro.
Topics: Animals; Burkitt Lymphoma; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Humans; Leucine; Mammalian orthoreovirus 3; Mice; Mice, SCID; Oncolytic Virotherapy; Oncolytic Viruses; Time Factors; Virion; Xenograft Model Antitumor Assays | 2006 |
Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d.
Topics: Animals; Antimalarials; Culicidae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Fluorescent Antibody Technique, Indirect; Gametogenesis; Humans; Immunoblotting; In Vitro Techniques; Leucine; Oocysts; Plasmodium falciparum | 2007 |
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cathepsin B; Cysteine Endopeptidases; Dipeptides; Guinea Pigs; Leucine; Molecular Weight; Protease Inhibitors; Synaptosomes | 2007 |
Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.
Topics: Administration, Oral; Animals; Blood Bactericidal Activity; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Disease Susceptibility; Female; Humans; Injections, Intraperitoneal; Leucine; Lysosomes; Male; Mice; Mice, Inbred C57BL; Protein Kinase C; Staphylococcal Infections; Survival Rate | 2007 |
Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.
Topics: Animals; Babesia bovis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Leucine; Leupeptins | 2007 |
Host cell cathepsins potentiate Moloney murine leukemia virus infection.
Topics: Animals; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Endocytosis; Leucine; Leukemia, Experimental; Lysosomes; Membrane Fusion; Mice; Moloney murine leukemia virus; NIH 3T3 Cells | 2007 |
Direct evidence for calpain involvement in apoptotic death of neurons in spinal cord injury in rats and neuroprotection with calpain inhibitor.
Topics: Animals; Apoptosis; Calpain; Cell Death; Cysteine Proteinase Inhibitors; DNA Fragmentation; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Leucine; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2007 |
Knockdown of NHERF1 enhances degradation of temperature rescued DeltaF508 CFTR from the cell surface of human airway cells.
Topics: Cell Line; Cell Membrane; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Epithelial Cells; Humans; Leucine; Leupeptins; Phosphoproteins; Protein Processing, Post-Translational; Protein Transport; Respiratory System; RNA Interference; Sodium-Hydrogen Exchangers; Temperature | 2007 |
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Humans; Leucine; Maze Learning; Memory; Mice; Mice, Transgenic | 2008 |
Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cathepsins; Cells, Cultured; Fibrosis; Heart Failure; Humans; Hypertension; Imidazoles; Leucine; Myocardium; Myocytes, Cardiac; NADPH Oxidases; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Sodium Chloride; Superoxides; Tetrazoles; Ventricular Remodeling | 2008 |
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Calpain; Cells, Cultured; Disease Models, Animal; Glycoproteins; Hippocampus; Homozygote; Immunohistochemistry; Leucine; Memory; Mice; Mice, Transgenic; Models, Neurological; Synaptic Transmission | 2008 |
Environmental effects on charge densities of biologically active molecules: do molecule crystal environments indeed approximate protein surroundings?
Topics: Computer Simulation; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Humans; Kringles; Leucine; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Plasminogen; Quantum Theory; Static Electricity; Tranexamic Acid | 2009 |
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Calpain; Cell Movement; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dyneins; Embryo, Mammalian; Female; Fibroblasts; Gene Expression Regulation, Developmental; Leucine; Leupeptins; Lissencephaly; Mice; Mice, Knockout; Microtubule-Associated Proteins; Models, Neurological; Neurons; Phenotype; Pregnancy | 2009 |
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.
Topics: Autophagy; bcl-X Protein; Caspase 8; Caspases; CD11b Antigen; Cell Survival; Chemokine CCL2; Cytokines; Humans; Interleukin-6; Leucine; Leukocytes, Mononuclear; Leupeptins; Lipopolysaccharide Receptors; Macrophages; Monocytes; Proto-Oncogene Proteins c-bcl-2 | 2009 |
Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosomes; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase 3; Cathepsins; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Etoposide; Fas Ligand Protein; Fibroblasts; Gene Knockdown Techniques; Interleukin-3; Leucine; Lysosomes; Mice; Monocytes; Ultraviolet Rays | 2010 |
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.
Topics: Animals; Biocatalysis; Cathepsin L; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Egtazic Acid; Granzymes; Humans; K562 Cells; Killer Cells, Natural; Leucine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Ovalbumin; Peptide Fragments; Peptide Hydrolases; Perforin; Pore Forming Cytotoxic Proteins; Recombinant Proteins; T-Lymphocytes, Cytotoxic | 2010 |
Effects of photodynamic therapy on the endocytic pathway.
Topics: Androstadienes; Animals; Cathepsins; Cell Line, Tumor; Cell Membrane; Diphenylhexatriene; Endocytosis; Endosomes; Fluorescent Dyes; Leucine; Lysosomes; Mice; Photochemotherapy; Photosensitizing Agents; Porphyrins; Time Factors; Vacuoles; Wortmannin | 2011 |
Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito.
Topics: Animals; Culicidae; Epoxy Compounds; Erythrocytes; Humans; Intracellular Membranes; Leucine; Microscopy, Electron; Nigericin; Nitrophenols; Plasmodium falciparum; Temperature; Tosyllysine Chloromethyl Ketone; Vacuoles; Xanthurenates | 2011 |
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cysteine Proteinase Inhibitors; Disease Models, Animal; Guinea Pigs; Leucine; Memory; Mice; Mice, Transgenic | 2011 |
Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
Topics: Blotting, Western; Carrier Proteins; Cathepsin G; Cell-Penetrating Peptides; Cells, Cultured; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Humans; Leucine; Pepstatins; Polymerase Chain Reaction; Proinsulin; T-Lymphocytes | 2011 |
Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplastic Stem Cells; RNA, Messenger; Sirolimus; Xenograft Model Antitumor Assays | 2011 |
Detecting autophagy in Arabidopsis roots by membrane-permeable cysteine protease inhibitor E-64d and endocytosis tracer FM4-64.
Topics: Arabidopsis; Autophagy; Cells, Cultured; Culture Media; Endocytosis; Leucine; Lysosomes; Plant Roots; Pyridinium Compounds; Quaternary Ammonium Compounds; Staining and Labeling; Vacuoles | 2011 |
M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture.
Topics: Animals; cis-trans-Isomerases; Cone Opsins; Cysteine Proteinase Inhibitors; Diterpenes; Eye; Leucine; Leupeptins; Lysosomes; Mice; Mice, Knockout; Organ Culture Techniques; Pepstatins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Real-Time Polymerase Chain Reaction; Retinaldehyde; Transcription, Genetic | 2012 |
Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; Glioblastoma; Host Specificity; Host-Pathogen Interactions; Humans; Leucine; Mammalian orthoreovirus 3; Molecular Sequence Data; Mutation; Neoplasms; Oncolytic Virotherapy; Protein Multimerization; Receptors, Cell Surface; Receptors, Virus; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Viral Proteins; Virus Internalization | 2012 |
The miR-290-295 cluster suppresses autophagic cell death of melanoma cells.
Topics: 3' Untranslated Regions; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Down-Regulation; Leucine; Melanoma; Mice; MicroRNAs; Microtubule-Associated Proteins; Multigene Family; Pepstatins; Protein Serine-Threonine Kinases; Sirolimus; Starvation | 2012 |
Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasite.
Topics: Amino Acid Sequence; Animals; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Enzyme Stability; Erythrocytes; Haplorhini; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Leucine; Malaria; Molecular Sequence Data; Papain; Parasites; Plasmodium knowlesi; Protein Transport; Proteolysis; Protozoan Proteins; Recombinant Proteins; Sequence Alignment; Substrate Specificity | 2012 |
Characterization of proteolytic activities during intestinal regeneration of the sea cucumber, Holothuria glaberrima.
Topics: Animals; Apoptosis; Cell Proliferation; Cysteine Proteinase Inhibitors; Holothuria; Intestines; Leucine; Leupeptins; Organogenesis; Proteolysis; Regeneration; Serine Proteinase Inhibitors; Tosylphenylalanyl Chloromethyl Ketone | 2012 |
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.
Topics: Acetic Acid; Apoptosis; Cathepsin B; Cathepsin D; Cathepsin L; Cell Line, Tumor; Cell Membrane Permeability; Colorectal Neoplasms; Humans; Hydrogen-Ion Concentration; Leucine; Lysosomes; Pepstatins | 2013 |
Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.
Topics: Androgens; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Dihydrotestosterone; Humans; Leucine; Leupeptins; Lysosomes; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Androgen; Transcriptome; Up-Regulation | 2013 |
Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.
Topics: Apoptosis; Breast; Breast Neoplasms; Cathepsin B; Cathepsin L; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Cysteine Proteinase Inhibitors; Dipeptides; Disease Progression; Epithelial Cells; Female; Humans; Leucine; Models, Biological | 2012 |
Quantitative analysis in LC3-II protein in vitro maturation of porcine oocyte.
Topics: Animals; Autophagy; Blotting, Western; Cells, Cultured; Cumulus Cells; Female; In Vitro Oocyte Maturation Techniques; Leucine; Microtubule-Associated Proteins; Oocytes; Pepstatins; Swine | 2014 |
Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro.
Topics: Aged; Blotting, Western; Carcinoma, Squamous Cell; Cathepsin K; Cell Line, Tumor; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Progression; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Leucine; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organ Culture Techniques; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tongue Neoplasms; Tumor Microenvironment | 2013 |
Excitotoxic glutamate insults block autophagic flux in hippocampal neurons.
Topics: Animals; Animals, Newborn; Autophagy; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; Leucine; Microtubule-Associated Proteins; Neurons; Pepstatins; Protease Inhibitors; Rats; Sequestosome-1 Protein; Statistics, Nonparametric | 2014 |
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cattle; Cells, Cultured; Chromaffin Cells; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Leucine; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2014 |
Autophagy inhibitors reduce avian-reovirus-mediated apoptosis in cultured cells and in chicken embryos.
Topics: Animals; Apoptosis; Autophagy; Chick Embryo; Chickens; Chloroquine; Leucine; Orthoreovirus, Avian; Pepstatins; Poultry Diseases; Reoviridae Infections | 2015 |
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.
Topics: Antimalarials; Artemisinins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Hemoglobins; Humans; Lethal Dose 50; Leucine; Malaria, Falciparum; Plasmodium falciparum; Proteolysis; Protozoan Proteins | 2016 |
Design, Synthesis, and Structure-Activity Relationship Study of Epoxysuccinyl-Peptide Derivatives as Cathepsin B Inhibitors.
Topics: Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Epoxy Compounds; Leucine; Pentanes; Peptides; Structure-Activity Relationship | 2017 |
The protease inhibitor E64d improves ox-LDL-induced endothelial dysfunction in human aortic endothelial cells.
Topics: Aorta; Autophagy; Cells, Cultured; Endothelial Cells; Humans; Leucine; Lipoproteins, LDL; Oxidative Stress | 2018 |
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
Topics: Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Calcium; Cathepsins; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Exocytosis; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; Lysosomes; Membrane Proteins; Mice; Neoplasm Metastasis; Nerve Tissue Proteins; Prognosis; Protein Isoforms; Proteolysis; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays | 2018 |
Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila.
Topics: Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Cysteine Endopeptidases; Endopeptidases; Legionella pneumophila; Leucine; Models, Molecular; Multigene Family; Phylogeny; Protein Structure, Secondary | 2018 |
Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Apoptosomes; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 9; Cathepsin B; Cathepsin C; Cathepsin D; Cathepsins; Cystatin B; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lysosomes; Membrane Potential, Mitochondrial; Mitochondria; Pepstatins; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Proteolysis; Signal Transduction; U937 Cells; Vitamin K 3 | 2019 |
Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology.
Topics: Animals; Blood-Brain Barrier; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Genes, Reporter; HEK293 Cells; Humans; Ketones; Leucine; Mice; Mitochondria; Motor Neurons; Muscular Atrophy, Spinal; Protective Agents; Protein Stability; Proteolysis; Signal Transduction; Survival of Motor Neuron 2 Protein; Transfection; Treatment Outcome | 2019 |
Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Cell Survival; Chloroquine; Doxorubicin; Drug Compounding; Drug Delivery Systems; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intracellular Space; Leucine; Liposomes; Mice | 2021 |