Page last updated: 2024-08-23

alovudine and zidovudine

alovudine has been researched along with zidovudine in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19909 (18.75)18.7374
1990's27 (56.25)18.2507
2000's4 (8.33)29.6817
2010's8 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balzarini, J; Bergstrom, DE; De Clercq, E; Mott, AW; Swartling, DJ1
Balzarini, J; Busson, R; De Clercq, E; Herdewijn, P; Hoogmartens, J; Janssen, G; Jie, L; Van Aerschot, A1
Balzarini, J; De Clercq, E; Herdewijn, P; Pauwels, R; Van Aerschot, A1
Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Janssen, G; Pauwels, R; Van Aerschot, A1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Antonenko, SV; Chentsova, NP; Kukhar, VP; Luik, AI; Poda, GI; Tetko, IV1
Knaus, EE; Kumar, R; Wang, L; Wiebe, LI1
Abraham, TW; McIntee, EJ; Remmel, RP; Schinazi, RF; Wagner, CR1
Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V1
Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X1
Agarwal, HK; Chhikara, BS; Doncel, GF; Parang, K; Quiterio, M1
Agarwal, HK; Buckheit, KW; Buckheit, RW; Parang, K1
Agarwal, HK; Chhikara, BS; Doncel, GF; Parang, K1
Böttiger, D; Li, SL; Oberg, B; Ståhle, L1
Böttiger, D; Guzenda, E; Ljungdahl-Ståhle, E; Oberg, B; Ståhle, L; Wahren, B1
Armstrong, D; Chou, TC; Kong, XB; Lang, SA; Muchmore, E; Ostrander, M; Polsky, B; Vidal, PM; Watanabe, KA; Zhu, QY1
Bregman, CL; Buroker, RA; Desiderio, JV; Ghazzouli, I; Hitchcock, MJ; Mansuri, MM; Martin, JC; Starrett, JE; Sterzycki, RZ1
Akesson-Johansson, A; Cox, S; Harmenberg, J; Vrang, L1
Cox, S; Harmenberg, J; Koshida, R; Wahren, B1
Foth, H; Frijus-Plessen, N; Kahl, GF; Michaelis, HC1
Böttiger, D; Ljungdahl-Ståhle, E; Lundgren, B; Norrby, E; Oberg, B; Ståhle, L; Wahren, B1
Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Gosselin, G; Herdewijn, P; Imbach, JL; Peeters, O; Van Aerschot, A1
Cox, S; Gilljam, G; Harmenberg, J; Koshida, R; Wahren, B1
Balzarini, J; De Clercq, E; Johns, DG; Matthes, E; Meeus, P1
Eckstein, F; Karlsson, A; Reichard, P1
Blau, IW; Elstner, E; Ihle, R; Langen, P; von Janta-Lipinski, M; Waechter, M1
Langen, P; Lehmann, C; Matthes, E; Rosenthal, HA; Scholz, D1
Durno, AG; Eckstein, F; Hartmann, H; Hirsch, MS; Hunsmann, G; Vogt, MW1
Albert, J; Cox, SW; Ljungdahl-Ståhle, E; Wahren, B1
Abdel-Bary, HM; Abel-Rahman, AA; Nielsen, C; Pedersen, EB1
Albert, J; Apéria, K; Cox, SW; Wahren, B1
Balzarini, J1
Ståhle, L1
Nielsen, C; Pedersen, EB; Schmidt, L1
Cheng, YC; Dutschman, GE; Lin, TS; Prusoff, WH; Zhu, JL1
Guzenda, E; Ljungdahl-Ståhle, E; Ståhle, L1
Faraj, A; Gosselin, G; Imbach, JL; Perigaud, C; Schinazi, RF; Sommadossi, JP; Xie, MY1
Dev, IK; Dornsife, RE; Joyner, SS; Moore, JT; Sundseth, R1
Averett, DR; Dornsife, RE1
Mankertz, J; Matthes, E; Pauli, G; Riedel, E; Rokos, K; von Baeyer, H1
Dabernat, S; Gonin, P; Janin, J; Kumar, R; Lacombe, ML; Lascu, I; Milon, L; Morr, M; Xu, Y1
Kim, EY; Merigan, TC; Oberg, B; Vrang, L1
Drontle, DP; Wagner, CR1
Agarwal, HK; Parang, K1
Eriksson, S; Sun, R; Wang, L2
Agarwal, HK; Doncel, GF; Parang, K1
Brul, S; de Boer, R; De Vos, WH; Manders, EM; Smith, RL; van der Spek, H1

Reviews

2 review(s) available for alovudine and zidovudine

ArticleYear
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
    Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine

1994
Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines.
    Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:4

    Topics: Amides; Amino Acids; Antineoplastic Agents; Antiviral Agents; Dideoxynucleosides; Drug Design; Fluorodeoxyuridylate; Humans; Molecular Structure; Nucleotides; Phosphoric Acids; Prodrugs; Pyrimidines; Time Factors; Zidovudine

2004

Other Studies

46 other study(ies) available for alovudine and zidovudine

ArticleYear
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.
    Journal of medicinal chemistry, 1992, Sep-04, Volume: 35, Issue:18

    Topics: Antiviral Agents; Dideoxynucleosides; HIV; Molecular Conformation; Structure-Activity Relationship

1992
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Dideoxynucleosides; HIV-1; Humans; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

1990
3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Dideoxynucleosides; HIV-1

1989
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:10

    Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; Magnetic Resonance Spectroscopy; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship; Virus Replication; Zidovudine

1988
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
HIV-1 reverse transcriptase inhibitor design using artificial neural networks.
    Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

    Topics: Algorithms; Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Structure; Neural Networks, Computer; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes; Zidovudine

1994
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxynucleosides; Drug Design; Hepatitis B virus; HIV-1; Molecular Structure; Prodrugs; Stereoisomerism; Virus Replication; Zidovudine

1994
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
    Journal of medicinal chemistry, 1997, Oct-10, Volume: 40, Issue:21

    Topics: Anti-HIV Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; HIV-1; Humans; Leukocytes, Mononuclear; Magnetic Resonance Spectroscopy; Prodrugs; Thymidine Monophosphate; Virus Replication; Zidovudine

1997
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
    Bioorganic & medicinal chemistry letters, 2003, Sep-15, Volume: 13, Issue:18

    Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides

2003
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
    Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

    Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor)

2010
Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.
    Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6

    Topics: Acetates; Anti-HIV Agents; Cell Line; Drug Resistance, Multiple, Viral; Esters; Glutamates; HIV-1; Humans; Myristic Acids; Nucleosides; Oligopeptides; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2012
Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Anti-HIV Agents; Cell Line; Dicarboxylic Acids; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2012
Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 05-01, Volume: 27, Issue:9

    Topics: Anti-HIV Agents; Dicarboxylic Acids; Esters; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Reverse Transcriptase Inhibitors

2017
Long-term tolerance and efficacy of 3'-azidothymidine and 3'-fluorothymidine treatment of asymptomatic monkeys infected with simian immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:8

    Topics: Anemia; Animals; Antiviral Agents; Blood Cell Count; CD4 Antigens; Dideoxynucleosides; Enzymes; Leukopenia; Macaca fascicularis; Simian Acquired Immunodeficiency Syndrome; Zidovudine

1992
Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Brain; Dialysis; Dideoxynucleosides; Extracellular Space; Macaca fascicularis; Muscles; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tissue Distribution; Veins; Virus Replication; Zidovudine

1992
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4

    Topics: Animals; Antiviral Agents; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Female; HIV; Humans; Macaca fascicularis; Male; Tritium; Zidovudine

1992
Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4

    Topics: Administration, Oral; Animals; Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV-1; Leukemia, Experimental; Male; Mice; Microbial Sensitivity Tests; Retroviridae; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine

1990
Synergistic inhibition of human immunodeficiency virus replication in vitro by combinations of 3'-azido-3'-deoxythymidine and 3'-fluoro-3'-deoxythymidine.
    AIDS research and human retroviruses, 1990, Volume: 6, Issue:10

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Drug Synergism; HIV-1; Humans; In Vitro Techniques; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Virus Replication; Zidovudine

1990
Synergistic combinations and peptides in the inhibition of human immunodeficiency virus.
    Advances in enzyme regulation, 1991, Volume: 31

    Topics: Alpha-Globulins; Amino Acid Sequence; Antiviral Agents; Cell Line; Dideoxynucleosides; Drug Synergism; Foscarnet; HIV; Humans; Molecular Sequence Data; Oligopeptides; Phosphonoacetic Acid; Proteins; Reverse Transcriptase Inhibitors; Serine Proteinase Inhibitors; Virus Replication; Zidovudine

1991
Determination of 3'-azido-3'-deoxythymidine, 2',3'-dideoxycytidine, 3'-fluoro-3'-deoxythymidine and 2',3'-dideoxyinosine in biological samples by high-performance liquid chromatography.
    Journal of chromatography, 1990, Dec-14, Volume: 534

    Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Didanosine; Dideoxynucleosides; Humans; Liver; Rats; Zalcitabine; Zidovudine

1990
Antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus.
    Journal of acquired immune deficiency syndromes, 1991, Volume: 4, Issue:5

    Topics: Animals; Antibodies, Viral; Antigens, Viral; Cells, Cultured; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Macaca fascicularis; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Viral Envelope Proteins; Zidovudine

1991
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
    Antiviral research, 1990, Volume: 14, Issue:6

    Topics: Antiviral Agents; Crystallography; Dideoxynucleosides; HIV; Humans; In Vitro Techniques; Molecular Structure; Structure-Activity Relationship; Virus Replication; X-Ray Diffraction; Zidovudine

1990
Structure-activity relationships of fluorinated nucleoside analogs and their synergistic effect in combination with phosphonoformate against human immunodeficiency virus type 1.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:12

    Topics: Antiviral Agents; Cells, Cultured; Dideoxynucleosides; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Foscarnet; HIV-1; Humans; Phosphonoacetic Acid; Structure-Activity Relationship; Virus Replication; Zidovudine

1989
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Antiviral Agents; Cell Division; Cell Line; Dideoxynucleosides; HIV; Humans; Virus Replication; Zalcitabine; Zidovudine

1989
Hydroxyurea increases the phosphorylation of 3'-fluorothymidine and 3'-azidothymidine in CEM cells.
    European journal of biochemistry, 1989, Dec-22, Volume: 186, Issue:3

    Topics: Antiviral Agents; Cell Division; Cell Line; Deoxyribonucleotides; Dideoxynucleosides; Humans; Hydroxyurea; Kinetics; Phosphorylation; Tumor Cells, Cultured; Zidovudine

1989
Sensitivity of CFU-GM from normal human bone marrow and leukaemic clonogenic cells (CFU-L) from blood of patients with myelogenous leukaemia to 3'-deoxy-3'-fluorothymidine in comparison to 3'-azido-3'-deoxythymidine.
    Blut, 1989, Volume: 59, Issue:5

    Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Dideoxynucleosides; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; Zidovudine

1989
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine.
    Biochemical and biophysical research communications, 1988, Jun-16, Volume: 153, Issue:2

    Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Mice; Phosphorylation; Rats; Thymidine; Virus Replication; Zidovudine

1988
Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:6

    Topics: Cell Line; Dideoxynucleosides; HIV-1; In Vitro Techniques; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine

1988
Effect of resistance on combination chemotherapy for human immunodeficiency virus infection.
    Advances in enzyme regulation, 1993, Volume: 33

    Topics: Antiviral Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; RNA-Directed DNA Polymerase; Virus Replication; Zidovudine

1993
Synthesis of 4-methylthio analogues of FLT and AZT and their evaluation against HIV.
    Archiv der Pharmazie, 1995, Volume: 328, Issue:1

    Topics: Antiviral Agents; Dideoxynucleosides; HIV-1; Zidovudine

1995
Comparison of the sensitivities of primary isolates of HIV type 2 and HIV type 1 to antiviral drugs and drug combinations.
    AIDS research and human retroviruses, 1994, Volume: 10, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Didanosine; Dideoxynucleosides; Drug Synergism; HIV-1; HIV-2; Humans; Leukocytes, Mononuclear; Zidovudine

1994
Zidovudine and alovudine as cross-wise recovery internal standards in microdialysis experiments?
    Journal of pharmacological and toxicological methods, 1994, Volume: 31, Issue:3

    Topics: Adipose Tissue; Animals; Brain; Dideoxynucleosides; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reference Standards; Zidovudine

1994
5'-Azido and 5'-fluoro alpha-nucleosides as analogues of AZT and FLT.
    Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1994, Volume: 48, Issue:3

    Topics: Animals; Antiviral Agents; Azides; Cell Line; Cells, Cultured; Dideoxynucleosides; Fluorides; HIV-1; Magnetic Resonance Spectroscopy; Molecular Conformation; Nucleosides; Rabbits; Simplexvirus; Zidovudine

1994
Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides.
    Journal of medicinal chemistry, 1993, Feb-05, Volume: 36, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Deoxyribonucleosides; Dideoxynucleosides; Drug Screening Assays, Antitumor; HIV-1; Humans; Mice; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine

1993
Pharmacokinetics and extracellular distribution to blood, brain, and muscle of alovudine (3'-fluorothymidine) and zidovudine in the rat studied by microdialysis.
    Journal of acquired immune deficiency syndromes, 1993, Volume: 6, Issue:5

    Topics: Animals; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Dialysis; Dideoxynucleosides; Extracellular Space; Isoelectric Point; Male; Microchemistry; Muscles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution; Zidovudine

1993
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
    Antiviral research, 1996, Volume: 29, Issue:2-3

    Topics: Antiviral Agents; Bone Marrow Cells; Cells, Cultured; Dideoxynucleosides; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Molecular Structure; Uridine; Zidovudine

1996
The anti-human immunodeficiency virus agent 3'-fluorothymidine induces DNA damage and apoptosis in human lymphoblastoid cells.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Antiviral Agents; Apoptosis; Camptothecin; CD4-Positive T-Lymphocytes; Cell Line; Dideoxynucleosides; DNA; DNA Damage; Electrophoresis, Agar Gel; Humans; Zidovudine

1996
In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:2

    Topics: Antiviral Agents; Cells, Cultured; Colony-Forming Units Assay; Dideoxynucleosides; Hematopoietic Stem Cells; Humans; Linear Models; Zalcitabine; Zidovudine

1996
Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.
    Biochimica et biophysica acta, 1996, Dec-16, Volume: 1317, Issue:3

    Topics: Cells, Cultured; Dideoxynucleosides; Endocytosis; HIV Infections; HIV Reverse Transcriptase; Humans; Leukocytes, Mononuclear; Lipoproteins, LDL; Receptors, LDL; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine

1996
Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography.
    Biochemistry, 1999, Jun-01, Volume: 38, Issue:22

    Topics: Animals; Catalysis; Crystallography, X-Ray; Deoxyribonucleotides; Dictyostelium; Dideoxynucleosides; Kinetics; Models, Chemical; Nucleoside-Diphosphate Kinase; Structure-Activity Relationship; Thymine Nucleotides; Viscosity; Zidovudine

1999
Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants.
    AIDS research and human retroviruses, 2001, Mar-20, Volume: 17, Issue:5

    Topics: Clone Cells; Dideoxynucleosides; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Drug Resistance, Multiple; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine

2001
Application of solid-phase chemistry for the synthesis of 3'-fluoro-3'-deoxythymidine.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:3

    Topics: Anti-HIV Agents; Chemistry, Pharmaceutical; Dideoxynucleosides; Drug Design; Models, Chemical; Molecular Structure; Polymers; Thymidine; Trifluoroacetic Acid; Zidovudine

2007
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
    Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:4-6

    Topics: Animals; Chromatography, Gel; Deoxycytidine; Dideoxynucleosides; Enzyme Activation; Humans; Mitochondria; Phosphorylation; Rats; Recombinant Proteins; Thymidine; Thymidine Kinase; Zidovudine

2010
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:6

    Topics: Animals; Antiviral Agents; Dideoxynucleosides; Female; Kinetics; Mitochondria; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine Kinase; Thymine Nucleotides; Zidovudine

2011
Synthesis and anti-HIV activities of suramin conjugates of 3'-fluoro- 2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:2

    Topics: Anti-HIV Agents; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Suramin; Zidovudine

2012
Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Anti-HIV Agents; Caenorhabditis elegans; Didanosine; Dideoxynucleosides; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Drug Evaluation; Humans; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxygen Consumption; Reverse Transcriptase Inhibitors; Stavudine; Ubiquinone; Zalcitabine; Zidovudine

2015