alnespirone has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 13 studies
| Studies (alnespirone) | Trials (alnespirone) | Recent Studies (post-2010) (alnespirone) | Studies (8-hydroxy-2-(di-n-propylamino)tetralin) | Trials (8-hydroxy-2-(di-n-propylamino)tetralin) | Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin) |
|---|---|---|---|---|---|
| 28 | 0 | 0 | 3,530 | 7 | 389 |
| Protein | Taxonomy | alnespirone (IC50) | 8-hydroxy-2-(di-n-propylamino)tetralin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.0012 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0032 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 0.8 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 2.8959 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.0021 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (92.31) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bizot-Espiard, J; Costentin, J; Guardiola, B; Schiavi, P; Simon, P | 1 |
| Barrett, JE; Gamble, EH; Guardiola-Lemaitre, B; Zhang, L | 1 |
| Chou, JM; Frazer, A; Scott, PA; Tang, H | 1 |
| Fattaccini, CM; Gozlan, H; Guardiola-Lemaitre, B; Haj-Dahmane, S; Hamon, M; Jolas, T; Kidd, EJ; Lanfumey, L | 1 |
| Haj-Dahmane, S; Hamon, M; Lanfumey, L | 1 |
| Blanchard, DC; Blanchard, RJ; Brush, MM; Griebel, G; Guardiola-Lemaître, B; Lee, J | 1 |
| Artigas, F; Casanovas, JM; Lésourd, M | 1 |
| Boni, C; Fabre, V; Hamon, M; Laporte, AM; Lesourd, M; Mocaër, E | 1 |
| Comoy, E; Lesourd, M; Protais, P | 1 |
| Artigas, F; Casanovas, JM; Mengod, G; Vilaró, MT | 1 |
| de Boer, SF; Koolhaas, JM; Lesourd, M; Mocaer, E | 1 |
| McGrath, C; Norman, TR | 1 |
| McKenzie-Quirk, SD; Miczek, KA | 1 |
13 other study(ies) available for alnespirone and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Aminoquinolines; Animals; Body Temperature; Buspirone; Chromans; Dopamine Agents; Male; Mice; Penile Erection; Propanolamines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Spiro Compounds; Thiophenes; Yawning | 1992 |
Anticonflict and discriminative stimulus effects in the pigeon of a new methoxy-chroman 5-HT1A agonist, (+)S 20244 and its enantiomers (+)S 20499 and (-)S 20500.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Columbidae; Conflict, Psychological; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Radioligand Assay; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Receptor Agonists; Spiro Compounds; Stereoisomerism | 1994 |
Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Chromans; Hypothermia; Kinetics; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds | 1994 |
New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Brain; Dopamine; Hippocampus; In Vitro Techniques; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Stereoisomerism | 1993 |
Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Chromans; Electrophysiology; Hippocampus; In Vitro Techniques; Indoles; Male; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Thiazoles | 1993 |
An ethopharmacological analysis of selective activation of 5-HT1A receptors: the mouse 5-HT1A syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Feeding Behavior; Grooming; Male; Mice; Motor Activity; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Species Specificity; Spiro Compounds; Syndrome; Time Factors | 1997 |
The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Area Under Curve; Brain; Extracellular Space; Male; Microdialysis; Piperazines; Pyridines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Spiro Compounds | 1997 |
[3H]Alnespirone: a novel specific radioligand of 5-HT1A receptors in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Autoradiography; Brain; Chlorides; Ethylmaleimide; Guanosine Triphosphate; Hydrogen-Ion Concentration; Ligands; Male; Manganese Compounds; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiro Compounds; Temperature | 1997 |
Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzazepines; Buspirone; Corpus Striatum; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Mice; Piperazines; Raclopride; Salicylamides; Serotonin; Serotonin Antagonists; Spiro Compounds; Tritium | 1998 |
Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Brain Chemistry; Dendrites; Depression; Dose-Response Relationship, Drug; Frontal Lobe; Gene Expression; In Situ Hybridization; Male; Microdialysis; Radioligand Assay; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Spiro Compounds | 1999 |
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Buspirone; Male; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds | 1999 |
(+)-S-20499 -- a potential antidepressant? A behavioural and neurochemical investigation in the olfactory bulbectomised rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Body Temperature; Brain Chemistry; Male; Nerve Tissue Proteins; Olfactory Bulb; Propanolamines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, beta-1; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds | 1999 |
5-HT1A agonists: alcohol drinking in rats and squirrel monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; Female; Injections, Intramuscular; Injections, Subcutaneous; Male; Piperazines; Pyridines; Rats; Rats, Long-Evans; Saimiri; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Spiro Compounds | 2003 |