Page last updated: 2024-09-05

alnespirone and 8-hydroxy-2-(di-n-propylamino)tetralin

alnespirone has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 13 studies

Compound Research Comparison

Studies
(alnespirone)
Trials
(alnespirone)
Recent Studies (post-2010)
(alnespirone)
Studies
(8-hydroxy-2-(di-n-propylamino)tetralin)
Trials
(8-hydroxy-2-(di-n-propylamino)tetralin)
Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin)
28003,5307389

Protein Interaction Comparison

ProteinTaxonomyalnespirone (IC50)8-hydroxy-2-(di-n-propylamino)tetralin (IC50)
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.0012
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0032
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.81
D(2) dopamine receptorBos taurus (cattle)0.8
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.81
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.81
D(2) dopamine receptorRattus norvegicus (Norway rat)2.8959
Lysosomal alpha-glucosidaseBos taurus (cattle)0.0021

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (92.31)18.2507
2000's1 (7.69)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bizot-Espiard, J; Costentin, J; Guardiola, B; Schiavi, P; Simon, P1
Barrett, JE; Gamble, EH; Guardiola-Lemaitre, B; Zhang, L1
Chou, JM; Frazer, A; Scott, PA; Tang, H1
Fattaccini, CM; Gozlan, H; Guardiola-Lemaitre, B; Haj-Dahmane, S; Hamon, M; Jolas, T; Kidd, EJ; Lanfumey, L1
Haj-Dahmane, S; Hamon, M; Lanfumey, L1
Blanchard, DC; Blanchard, RJ; Brush, MM; Griebel, G; Guardiola-Lemaître, B; Lee, J1
Artigas, F; Casanovas, JM; Lésourd, M1
Boni, C; Fabre, V; Hamon, M; Laporte, AM; Lesourd, M; Mocaër, E1
Comoy, E; Lesourd, M; Protais, P1
Artigas, F; Casanovas, JM; Mengod, G; Vilaró, MT1
de Boer, SF; Koolhaas, JM; Lesourd, M; Mocaer, E1
McGrath, C; Norman, TR1
McKenzie-Quirk, SD; Miczek, KA1

Other Studies

13 other study(ies) available for alnespirone and 8-hydroxy-2-(di-n-propylamino)tetralin

ArticleYear
5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Aminoquinolines; Animals; Body Temperature; Buspirone; Chromans; Dopamine Agents; Male; Mice; Penile Erection; Propanolamines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Spiro Compounds; Thiophenes; Yawning

1992
Anticonflict and discriminative stimulus effects in the pigeon of a new methoxy-chroman 5-HT1A agonist, (+)S 20244 and its enantiomers (+)S 20499 and (-)S 20500.
    Psychopharmacology, 1994, Volume: 116, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Columbidae; Conflict, Psychological; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Radioligand Assay; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Receptor Agonists; Spiro Compounds; Stereoisomerism

1994
Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Chromans; Hypothermia; Kinetics; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds

1994
New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Brain; Dopamine; Hippocampus; In Vitro Techniques; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Stereoisomerism

1993
Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525.
    European journal of pharmacology, 1993, Nov-02, Volume: 249, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Chromans; Electrophysiology; Hippocampus; In Vitro Techniques; Indoles; Male; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Thiazoles

1993
An ethopharmacological analysis of selective activation of 5-HT1A receptors: the mouse 5-HT1A syndrome.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Feeding Behavior; Grooming; Male; Mice; Motor Activity; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Species Specificity; Spiro Compounds; Syndrome; Time Factors

1997
The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain.
    British journal of pharmacology, 1997, Volume: 122, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Area Under Curve; Brain; Extracellular Space; Male; Microdialysis; Piperazines; Pyridines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Spiro Compounds

1997
[3H]Alnespirone: a novel specific radioligand of 5-HT1A receptors in the rat brain.
    European journal of pharmacology, 1997, Oct-22, Volume: 337, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Autoradiography; Brain; Chlorides; Ethylmaleimide; Guanosine Triphosphate; Hydrogen-Ion Concentration; Ligands; Male; Manganese Compounds; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiro Compounds; Temperature

1997
Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone.
    European journal of pharmacology, 1998, Jul-10, Volume: 352, Issue:2-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzazepines; Buspirone; Corpus Striatum; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Mice; Piperazines; Raclopride; Salicylamides; Serotonin; Serotonin Antagonists; Spiro Compounds; Tritium

1998
Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain.
    Journal of neurochemistry, 1999, Volume: 72, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Brain Chemistry; Dendrites; Depression; Dose-Response Relationship, Drug; Frontal Lobe; Gene Expression; In Situ Hybridization; Male; Microdialysis; Radioligand Assay; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Spiro Compounds

1999
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Buspirone; Male; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds

1999
(+)-S-20499 -- a potential antidepressant? A behavioural and neurochemical investigation in the olfactory bulbectomised rat.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Body Temperature; Brain Chemistry; Male; Nerve Tissue Proteins; Olfactory Bulb; Propanolamines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, beta-1; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds

1999
5-HT1A agonists: alcohol drinking in rats and squirrel monkeys.
    Psychopharmacology, 2003, Volume: 167, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; Female; Injections, Intramuscular; Injections, Subcutaneous; Male; Piperazines; Pyridines; Rats; Rats, Long-Evans; Saimiri; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Spiro Compounds

2003