Page last updated: 2024-09-03

almotriptan and rizatriptan

almotriptan has been researched along with rizatriptan in 30 studies

Compound Research Comparison

Studies (almotriptan)	Trials (almotriptan)	Recent Studies (post-2010) (almotriptan)	Studies (rizatriptan)	Trials (rizatriptan)	Recent Studies (post-2010) (rizatriptan)
188	59	42	349	106	75

Protein Interaction Comparison

Protein	Taxonomy	rizatriptan (IC50)
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	0.3572
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	6.3096
5-hydroxytryptamine receptor 1D	Homo sapiens (human)	0.0452
5-hydroxytryptamine receptor 1B	Homo sapiens (human)	0.041
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	7.9433
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	7.9433
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	3.9811
5-hydroxytryptamine receptor 1D	Sus scrofa (pig)	0.0501
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	3.9811

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	23 (76.67)	29.6817
2010's	6 (20.00)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Deleu, D; Hanssens, Y	1
Hashimoto, S; Iwata, M	1
Marcus, DA	1
Ferrari, MD; Goadsby, PJ; Lipton, RB; Roon, KI	1
Freitag, FG	1
Rapoport, AM; Sheftell, FD; Tepper, SJ	1
Csiba, L; Ficzere, A	1
Adelman, JU; Lewit, EJ	1
Reeder, CE; Williams, P	1
Cabarrocas, X	1
Jähnichen, S; Pertz, HH; Radtke, OA	1
Tfelt-Hansen, P	1
Dodick, DW; Ferrari, MD; Goadsby, PJ; McCrory, DC; Williams, P	1
López-Gil, A	1
Kowa, H; Nakashima, K; Takeshima, T	1
Muñoz, P; Pascual, J	1
Capuano, A; Di Trapani, G; Evangelista, M; Ferraro, D; Mei, D; Pierguidi, L; Vollono, C	1
Acuto, G; Caiola, F; Gori, S; Iudice, A; Morelli, N; Murri, L	1
Díez, FI; Straube, A; Zanchin, G	1
Bigal, M; Hu, XH; Ng-Mak, DS	1
Allais, G; Benedetto, C; Bussone, G; Omboni, S; Pezzola, D; Tullo, V; Zava, D	1
Allais, G; Barbanti, P; Benedetto, C; Bussone, G; Cortelli, P; Curone, M; Omboni, S; Peccarisi, C; Pezzola, D; Tullo, V; Zava, D	1
Evers, S	1
Evers, S; Lisotto, C; Omboni, S; Pinessi, L; Savi, L; Zanchin, G	1
Han, W; Li, M; Wang, J; Xu, H	1
Amundsen, S; Fuskevåg, OM; Nordeng, H; Nordmo, E; Sager, G; Spigset, O	1

Reviews

14 review(s) available for almotriptan and rizatriptan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Current and emerging second-generation triptans in acute migraine therapy: a comparative review. Journal of clinical pharmacology, 2000, Volume: 40, Issue:7 Topics: Acute Disease; Carbazoles; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Triazoles; Tryptamines	2000
[Current topics: expectation for new triptans]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2001, Apr-10, Volume: 90, Issue:4 Topics: Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines	2001
Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans). Archives of neurology, 2001, Volume: 58, Issue:7 Topics: Analgesics, Non-Narcotic; Carbazoles; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Oxazolidinones; Pain Measurement; Patient Satisfaction; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Time Factors; Treatment Outcome; Triazoles; Tryptamines	2001
Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet (London, England), 2001, Nov-17, Volume: 358, Issue:9294 Topics: Acute Disease; Administration, Oral; Humans; Indoles; Migraine Disorders; Pyrrolidines; Randomized Controlled Trials as Topic; Recurrence; Serotonin Receptor Agonists; Severity of Illness Index; Treatment Outcome; Triazoles; Tryptamines	2001
Acute treatment of migraine and the role of triptans. Current neurology and neuroscience reports, 2001, Volume: 1, Issue:2 Topics: Acute Disease; Blood Flow Velocity; Carbazoles; Clinical Trials as Topic; Drug Administration Routes; Female; Humans; Indoles; Male; Menstruation; Migraine Disorders; Oxazolidinones; Piperidines; Practice Guidelines as Topic; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Vasoconstriction; Vasoconstrictor Agents	2001
Mechanisms of action of the 5-HT1B/1D receptor agonists. Archives of neurology, 2002, Volume: 59, Issue:7 Topics: Carbazoles; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines	2002
[Treatment of migraine in patients with hypertension and ischemic heart disease]. Ideggyogyaszati szemle, 2002, Jan-20, Volume: 55, Issue:1-2 Topics: Adjuvants, Pharmaceutic; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Contraindications; Dihydroergotamine; Dopamine Agonists; Ergotamine; Humans; Hypertension; Indoles; Migraine Disorders; Myocardial Ischemia; Oxazolidinones; Retrospective Studies; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents	2002
Comparative aspects of triptans in treating migraine. Clinical cornerstone, 2001, Volume: 4, Issue:3 Topics: Carbazoles; Cardiovascular Diseases; Humans; Indoles; Migraine Disorders; Oxazolidinones; Patient Satisfaction; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines	2001
[Meta-analysis of triptan treatment in migraine]. No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:9 Topics: Carbazoles; Evidence-Based Medicine; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1D; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines	2004
Efficacy of frovatriptan and other triptans in the treatment of acute migraine of hypertensive and normotensive subjects: a review of randomized studies. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013, Volume: 34 Suppl 1 Topics: Carbazoles; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Migraine Disorders; Oxazolidinones; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Triazoles; Tryptamines	2013
The efficacy of triptans in childhood and adolescence migraine. Current pain and headache reports, 2013, Volume: 17, Issue:7 Topics: Adolescent; Analgesics; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Germany; Humans; Male; Migraine Disorders; Oxazolidinones; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines	2013
Efficacy of frovatriptan as compared to other triptans in migraine with aura. The journal of headache and pain, 2015, Volume: 16 Topics: Adult; Carbazoles; Female; Humans; Male; Middle Aged; Migraine with Aura; Oxazolidinones; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Tryptamines	2015
Network meta-analysis of migraine disorder treatment by NSAIDs and triptans. The journal of headache and pain, 2016, Volume: 17, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Migraine Disorders; Oxazolidinones; Pyrrolidines; Randomized Controlled Trials as Topic; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines	2016

Trials

4 trial(s) available for almotriptan and rizatriptan

Article	Year
Meta-analysis of oral triptans. Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:8 Topics: Administration, Oral; Clinical Trials as Topic; Humans; Indoles; Meta-Analysis as Topic; Pain; Pyrrolidines; Serotonin Receptor Agonists; Triazoles; Tryptamines	2004
Multiple attack study on the available triptans in Italy versus placebo. European journal of neurology, 2005, Volume: 12, Issue:7 Topics: Adult; Female; Humans; Indoles; Italy; Male; Middle Aged; Migraine Disorders; Oxazolidinones; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines	2005
Patient preference in migraine therapy. A randomized, open-label, crossover clinical trial of acute treatment of migraine with oral almotriptan and rizatriptan. Journal of neurology, 2007, Volume: 254, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Female; Humans; Male; Meta-Analysis as Topic; Middle Aged; Migraine Disorders; Patient Satisfaction; Serotonin Receptor Agonists; Single-Blind Method; Time Factors; Triazoles; Tryptamines	2007
Migraine treatment with rizatriptan and almotriptan: a crossover study. Headache, 2009, Volume: 49, Issue:5 Topics: Adult; Cross-Over Studies; Female; Humans; Male; Middle Aged; Migraine Disorders; Pain Measurement; Patient Satisfaction; Proportional Hazards Models; Prospective Studies; Serotonin Receptor Agonists; Time Factors; Treatment Outcome; Triazoles; Tryptamines	2009

Other Studies

12 other study(ies) available for almotriptan and rizatriptan

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cost-effectiveness of almotriptan and rizatriptan in the treatment of acute migraine. Clinical therapeutics, 2003, Volume: 25, Issue:11 Topics: Acute Disease; Cost-Benefit Analysis; Decision Support Techniques; Female; Health Care Costs; Health Services; Humans; Indoles; Male; Migraine Disorders; Serotonin Receptor Agonists; Triazoles; Tryptamines	2003
Evaluating triptan usage. Headache, 2004, Volume: 44, Issue:2 Topics: Clinical Trials as Topic; Humans; Indoles; Pharmacies; Serotonin Receptor Agonists; Spain; Triazoles; Tryptamines	2004
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:1 Topics: Animals; Benzamides; Brain; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Female; Forecasting; Guinea Pigs; Iliac Artery; Indoles; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Oxazolidinones; Piperazines; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sumatriptan; Triazoles; Tryptamines	2004
TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management. Acta neurologica Scandinavica, 2004, Volume: 110, Issue:3 Topics: Administration, Oral; Adult; Data Collection; Decision Support Techniques; Dose-Response Relationship, Drug; Female; Humans; Indoles; Meta-Analysis as Topic; Migraine Disorders; Patient Satisfaction; Patient Selection; Pyrrolidines; Serotonin Receptor Agonists; Treatment Outcome; Triazoles; Tryptamines	2004
Evaluating triptan usage: a rebuttal. Headache, 2004, Volume: 44, Issue:9 Topics: Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Serotonin Receptor Agonists; Triazoles; Tryptamines	2004
Correlation between lipophilicity and triptan outcomes. Headache, 2005, Volume: 45, Issue:1 Topics: Central Nervous System Diseases; Chemical Phenomena; Chemistry, Physical; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Statistics as Topic; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines	2005
A pharmacoeconomic evaluation of oral triptans in the treatment of migraine in Italy. Minerva medica, 2006, Volume: 97, Issue:6 Topics: Administration, Oral; Cost-Benefit Analysis; Decision Trees; Humans; Italy; Migraine Disorders; Sensitivity and Specificity; Triazoles; Tryptamines	2006
Frovatriptan vs. other triptans for the acute treatment of oral contraceptive-induced menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013, Volume: 34 Suppl 1 Topics: Carbazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Double-Blind Method; Female; Humans; Menstruation; Migraine Disorders; Multicenter Studies as Topic; Oxazolidinones; Premenstrual Syndrome; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Triazoles; Tryptamines	2013
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:6 Topics: Adult; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Migraine Disorders; Milk, Human; Oxazolidinones; Piperidines; Pyrrolidines; Triazoles; Tryptamines	2021