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allopregnane-3,20-diol and gamma-aminobutyric acid

allopregnane-3,20-diol has been researched along with gamma-aminobutyric acid in 4 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(allopregnane-3,20-diol)
Trials
(allopregnane-3,20-diol)
Recent Studies (post-2010)
(allopregnane-3,20-diol)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
120040,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomyallopregnane-3,20-diol (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cadoni, C; Gee, KW1
Smith, SS; Waterhouse, BD; Woodward, DJ1
Backstrom, T; Birzniece, V; Johansson, IM; Lundgren, P; Turkmen, S; Zingmark, E1
Bäckström, T; Haage, D; Lundgren, P; Strömberg, J; Taube, M; Wang, M1

Other Studies

4 other study(ies) available for allopregnane-3,20-diol and gamma-aminobutyric acid

ArticleYear
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.
    European journal of pharmacology, 1992, Oct-01, Volume: 227, Issue:2

    Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism

1992
Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum.
    Brain research bulletin, 1987, Volume: 18, Issue:6

    Topics: Animals; Drug Interactions; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Pregnanediol; Pregnanes; Pregnanolone; Purkinje Cells; Rats; Rats, Inbred Strains

1987
3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone.
    The European journal of neuroscience, 2004, Volume: 20, Issue:6

    Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebral Cortex; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Pregnanediol; Pregnanolone; Radioimmunoassay; Rats; Rats, Wistar; Reaction Time; Statistics, Nonparametric; Time Factors

2004
The effect of the neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol on the time course of GABA evoked currents is different to that of pregnenolone sulphate.
    European journal of pharmacology, 2009, Mar-01, Volume: 605, Issue:1-3

    Topics: Animals; Electrophysiology; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Patch-Clamp Techniques; Pregnanediol; Pregnenolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Time Factors

2009