Page last updated: 2024-08-23

alkenes and piperidines

alkenes has been researched along with piperidines in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.41)18.7374
1990's4 (4.55)18.2507
2000's38 (43.18)29.6817
2010's36 (40.91)24.3611
2020's7 (7.95)2.80

Authors

AuthorsStudies
Trybulski, EJ; Tufariello, JJ1
Ferko, AP1
Akella, SK; Efange, SM; Foulon, C; Khare, AB; Parsons, SM1
Kawakami, K; Mase, T; Mitsuya, M; Miura, K; Ogino, Y1
Fujikawa, T; Hattori, H; Kawakami, K; Kimura, T; Kobayashi, K; Mase, T; Mitsuya, M; Noguchi, K; Ogino, Y; Ohtake, N; Satoh, A; Tomimoto, K; Tsuchiya, Y1
Hasegawa, T; Kawakami, K; Kimura, T; Mase, T; Mitsuya, M; Noguchi, K; Numazawa, T; Ogino, Y; Ohtake, N; Uchiyama, M1
Holmes, AB; Tan, CH1
Beak, P; Curtis, MD; Johnson, TA1
Marks, TJ; McDonald, FE; Ryu, JS1
Katsumura, S; Tanaka, K1
Nagao, Y; Ogawa, S; Sano, S; Takehisa, T; Yokoyama, K1
Beak, P; Curtis, MD; Jang, DO; Johnson, TA; Slafer, BW1
Chisholm, JD; Jung, M; Trost, BM; Wrobleski, ST1
Chen, IS; Chen, JJ; Chen, YC; Huang, YC; Huang, YT; Peng, CY; Teng, CM; Wang, SW1
Hoveyda, AH; Josephsohn, NS; Snapper, ML1
KAKU, T; KASE, Y; NAGAO, K; TAKASAKI, Y; TANAKA, M; YAMAMOTO, Y1
Ball, S; Dixon, N; Findlay, JB; Harrison, MA; Kee, TP; Marsh, D; Pali, T1
Tomioka, K; Yamada, K; Yamashita, M1
de Jong, H; Feringa, BL; Meetsma, A; ter Wiel, MK; van Delden, RA1
Fujita, M; Fujiwara, K; Hirayama, S; Kim, WH; Ohki, Y; Okuyama, T; Sakanishi, Y; Tatsumi, K; Yoshioka, Y1
Afshan, F; Begum, S; Gulzar, T; Siddiqui, BS1
Han, H; Singh, OV1
Hall, DG; Touré, BB1
Adlington, RM; Baldwin, JE; Cowley, AR; Tchabanenko, K1
Christodoulopoulou, L; Petrakis, PV; Roussis, V; Tsoukatou, M; Tziveleka, LA; Vagias, C1
Augustyns, K; De Meester, I; Haemers, A; Kertèsz, I; Lambeir, AM; Maes, MB; Scharpé, S; Senten, K; Van der Veken, P1
Baiazitov, RY; Denmark, SE1
Bahia, PS; Kariuki, BM; Philp, D; Snaith, JS; Spencer, N; Williams, JT1
Bühle, P; Heinrich, T; Junker, B; Reggelin, M; Slavik, S1
Banerjee, A; Crich, D1
Agius, L; Arden, C; Elemes, Y; Ganotidis, M; Hampson, LJ; Kosmopoulou, MN; Leonidas, DD; Oikonomakos, NG; Sakarellos, C; Tiraidis, C1
Ahmed, M; Beller, M; Buch, C; Jackstell, R; Klein, H; Routaboul, L; Spannenberg, A1
Chemler, SR; Fuller, PH; Kasi, D; Sherman, ES1
Cortez, GA; Hoveyda, AH; Schrock, RR1
Micalizio, GC; Takahashi, M1
Corniquet, XG; Marsh, GP; McCarthy, C; Parsons, PJ1
Banerjee, A; Nelson, SG; Sarkar, N1
Bawankule, DU; Chanda, D; Darokar, MP; Luqman, S; Mani, D; Pal, A; Shanker, K1
Vedejs, E; Wang, G1
Akhmedov, NG; Chen, Y; Petersen, JL; Shi, X; Zhong, C1
Bachmann, C; Jouannetaud, MP; Marrot, J; Martin-Mingot, A; Thibaudeau, S; Vardelle, E1
Leonard, NM; Woerpel, KA1
Amanlou, M; Foroumadi, A; Rayatnia, F; Sakhteman, A; Shafiee, A; Sharifzadeh, M1
Fu, R; Shi, Y; Zhao, B1
Cheng, G; Hu, Y; Liu, F; Liu, H; Su, D; Wang, X1
Cheng, G; Hu, Y; Liu, H; Su, D; Wang, X; Xu, J1
Chen, H; Chen, SR; Pan, HL; Wess, J; Yuan, WX1
Bonjoch, J; Diaba, F1
Mukherjee, P; Widenhoefer, RA1
Abdulreda, MH; Berggren, PO; Caicedo, A; Dando, R; Fachado, A; Jacques-Silva, MC; Molina, J; Ricordi, C; Rodriguez-Diaz, R; Roper, SD1
Park, IK1
Bader, SJ; Bagley, SW; Bernhardson, DJ; Cabral, S; Edmonds, DJ; Griffith, DA; Kung, DW; Polivkova, J; Rose, CR; Southers, JA; Yang, X1
Leow, D; Li, G; Mei, TS; Yu, JQ1
Atodiresei, I; Bolm, C; Jörres, M; Schiffers, I1
Li, Z; Meng, X; Ning, M; Wang, Q; Wei, X; Zhong, W1
Duan, XF; Liao, LY; Zhang, F; Zhang, S1
Murunikkara, V; Rasool, M2
Achrainer, F; Šakić, D; Vrček, V; Zipse, H1
Kumari, M; Martande, SS; Naik, SB; Pradeep, AR; Rao, NS1
Blunder, M; Flores-Soto, ME; Gachet, MS; Gertsch, J; Nicolussi, S; Rau, M; Viveros-Paredes, JM1
Balaboina, R; Kankala, RK; Kankala, S; Thirukovela, NS; Vadde, R; Vasam, CS1
Chaiyakunapruk, N; Maenthaisong, R; Rojanawiwat, A; Tawatsin, A; Thavara, U; Tiyaboonchai, W1
Bahadur, S; Bhadra, S; Harwansh, RK; Kar, A; Mitra, A; Mukherjee, K; Mukherjee, PK1
Andersen, TL; Lindhardt, AT; Modvig, A; Skrydstrup, T; Taaning, RH1
Chi, HM; Denmark, SE1
Forrest, AR; Hasegawa, Y; Hayashizaki, Y; Suzuki, H; Takahashi, N; Tang, D1
Harty, RC; Miyazaki, H; Nukina, N; Petrou, S; Phillips, AM; Richards, KL; Wimmer, VC1
Hering, S; Khom, S; Mihovilovic, MD; Pakfeifer, P; Schöffmann, A; Schönbauer, D; Wimmer, L1
Murunikkara, V; Rasool, MK1
Chu, JC; Dalton, DM; Rovis, T1
Hammond, GB; Okoromoba, OE; Xu, B1
Cao, P; Jia, T; Liao, J; Lou, Y; Wang, B; Wang, M; Yin, X1
Chadda, R; McArdle, P; Moynihan, L; Murphy, PV1
Chen, SR; Pan, HL; Zhu, Y1
Chen, P; Liu, G; Wu, L1
Bhargava, VK; Garg, SK; Karan, RS1
Doss, HM; Ganesan, R; Rasool, M1
Basile, A; Bruno, M; Di Napoli, M; Maggi, F; Varcamonti, M; Zanfardino, A1
Göttemann, LT; Kuroda, Y; Roque, JB; Sarpong, R1
Diao, T; Lin, Q1
Alom, NE; Ariyarathna, JP; Kaur, N; Li, W; Wu, F1
Bognár, B; Hideg, K; Isbera, M; Jekő, J; Kálai, T; Sár, C1
Safaei, E; Taghizadeh, M1
Kollery Suresh, V; Lankalapalli, RS; Mullan Velandy, R; Natakkakath Kaliyathan, R; Neenthamadathil Mohandas, K; Somasekharan Nair Rajam, S; Sreedharan Nair, R; Vellolipadikkal, H; Viswanathan Leena, S1
Dixit, AK; Javed, D1
Bennett, J; Dhara, A; Dhara, D; Murphy, PV1
Jiang, H; Jin, Y; Jing, Y; Ke, Z; Li, C; Li, M; Wu, W1

Reviews

2 review(s) available for alkenes and piperidines

ArticleYear
Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review.
    Journal of complementary & integrative medicine, 2022, Jun-01, Volume: 19, Issue:2

    Topics: Alkenes; COVID-19 Drug Treatment; Humans; Piperidines; Randomized Controlled Trials as Topic; SARS-CoV-2; Systematic Reviews as Topic

2022
Cyclisations and Strategies for Stereoselective Synthesis of Piperidine Iminosugars.
    Chemical record (New York, N.Y.), 2021, Volume: 21, Issue:11

    Topics: Alkenes; Azides; Cycloaddition Reaction; Piperidines

2021

Trials

2 trial(s) available for alkenes and piperidines

ArticleYear
Clinical efficacy of a herbal dentifrice on dentinal hypersensitivity: a randomized controlled clinical trial.
    Australian dental journal, 2013, Volume: 58, Issue:4

    Topics: Adult; Air; Alkenes; Cinnamomum zeylanicum; Dentifrices; Dentin Sensitivity; Double-Blind Method; Female; Humans; India; Male; Middle Aged; Nitrates; Phytotherapy; Piperidines; Plant Extracts; Potassium Compounds; Spinacia oleracea; Syzygium; Water; Zinc Oxide

2013
Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial.
    Complementary therapies in medicine, 2014, Volume: 22, Issue:1

    Topics: Adult; Aedes; Alkenes; Animals; Erythema; Female; Humans; Insect Bites and Stings; Male; Piperidines; Plant Extracts; Pruritus

2014

Other Studies

84 other study(ies) available for alkenes and piperidines

ArticleYear
A synthetic approach to the skeleton of histrionicotoxin.
    The Journal of organic chemistry, 1974, Nov-14, Volume: 39, Issue:23

    Topics: Alkaloids; Alkenes; Alkynes; Cyclization; Glycosides; Methods; Oxidation-Reduction; Parasympatholytics; Piperidines; Venoms

1974
Some cardiac effects of 1-allyl-2-benzyl-piperidine hc1, in vitro and in vivo.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196, Issue:2

    Topics: Alkenes; Allyl Compounds; Animals; Anti-Arrhythmia Agents; Anura; Benzyl Compounds; Calcium Chloride; Depression, Chemical; Drug Antagonism; Guinea Pigs; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Lethal Dose 50; Lidocaine; Neuromuscular Junction; Norepinephrine; Ouabain; Piperidines; Sciatic Nerve; Ventricular Fibrillation

1972
Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function.
    Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

    Topics: Acetylcholine; Alkenes; Animals; Electric Organ; Ethylenes; Indenes; Molecular Conformation; Molecular Structure; Neuromuscular Depolarizing Agents; Piperidines; Receptors, Cholinergic; Structure-Activity Relationship; Synaptic Vesicles; Vinyl Compounds

1994
Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: Alkenes; Crystallography, X-Ray; Molecular Structure; Muscarinic Antagonists; Piperidines; Receptor, Muscarinic M3; Receptors, Muscarinic

1999
J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors.
    Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:11

    Topics: Alkenes; Animals; Bronchodilator Agents; CHO Cells; Cricetinae; Humans; Male; Muscarinic Antagonists; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Structure-Activity Relationship; Trachea

1999
Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:4

    Topics: Alkenes; Cyclopentanes; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscarinic Antagonists; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic

2000
The synthesis of (+)-allopumiliotoxin 323B'.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2001, May-04, Volume: 7, Issue:9

    Topics: Alkaloids; Alkenes; Amphibian Venoms; Animals; Indolizines; Molecular Structure; Piperidines; Ranidae; Stereoisomerism

2001
Highly diastereoselective and enantioselective carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylamines to nitroalkenes: enantioselective synthesis of 3,4- and 3,4,5-substituted piperidines including (-)-paroxetine.
    Journal of the American Chemical Society, 2001, Feb-07, Volume: 123, Issue:5

    Topics: Alkenes; Amines; Carbon; Paroxetine; Piperidines; Stereoisomerism

2001
Organolanthanide-catalyzed intramolecular hydroamination/cyclization of amines tethered to 1,2-disubstituted alkenes.
    Organic letters, 2001, Oct-04, Volume: 3, Issue:20

    Topics: Alkenes; Amines; Lanthanoid Series Elements; Molecular Conformation; Organometallic Compounds; Piperidines; Pyrrolidines

2001
Highly stereoselective asymmetric 6pi-azaelectrocyclization utilizing the novel 7-alkyl substituted cis-1-amino-2-indanols: formal synthesis of 20-epiuleine.
    Journal of the American Chemical Society, 2002, Aug-21, Volume: 124, Issue:33

    Topics: Aldehydes; Alkenes; Amines; Aza Compounds; Cyclization; Dihydropyridines; Indans; Indole Alkaloids; Piperidines; Stereoisomerism

2002
Stereoselective synthesis of tetrasubstituted (Z)-alkenes from aryl alkyl ketones utilizing the Horner-Wadsworth-Emmons reaction.
    Chemical & pharmaceutical bulletin, 2002, Volume: 50, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkenes; Catalysis; Cinnamates; Indicators and Reagents; Ketones; Methylation; Piperidines; Stereoisomerism

2002
Asymmetric carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylic and benzylic amines to nitroalkenes: enantioselective synthesis of substituted piperidines, pyrrolidines, and pyrimidinones.
    Journal of the American Chemical Society, 2002, Oct-02, Volume: 124, Issue:39

    Topics: Alkenes; Amines; Benzylamines; Formic Acid Esters; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Pyrimidinones; Pyrrolidines; Stereoisomerism

2002
Ruthenium-catalyzed alkene-alkyne coupling: synthesis of the proposed structure of amphidinolide A.
    Journal of the American Chemical Society, 2002, Oct-23, Volume: 124, Issue:42

    Topics: Alkenes; Alkylation; Alkynes; Catalysis; Lactones; Macrolides; Piperidines; Ruthenium

2002
Cytotoxic amides from Piper sintenense.
    Planta medica, 2002, Volume: 68, Issue:11

    Topics: Alkenes; Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cell Survival; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Muscle, Smooth, Vascular; Phytotherapy; Piper; Piperidines; Plant Extracts; Rats; Tumor Cells, Cultured

2002
Efficient and practical Ag-catalyzed cycloadditions between arylimines and the Danishefsky diene.
    Journal of the American Chemical Society, 2003, Apr-09, Volume: 125, Issue:14

    Topics: Alkenes; Catalysis; Cyclization; Imines; Piperidines; Silver; Stereoisomerism

2003
3-Piperidyl-1, 1-di(2'-thienyl)-but-1-ene as a potent antitussive.
    Pharmaceutical bulletin, 1955, Volume: 3, Issue:5

    Topics: Alkenes; Antitussive Agents; Cough; Piperidines

1955
New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes.
    Organic & biomolecular chemistry, 2003, Dec-21, Volume: 1, Issue:24

    Topics: Alkenes; Amides; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Indoles; Isomerism; Models, Biological; Models, Chemical; Molecular Structure; Piperidines; Spin Labels; Structure-Activity Relationship; Temperature; Vacuolar Proton-Translocating ATPases; Yeasts

2003
Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929.
    Journal of the American Chemical Society, 2004, Feb-25, Volume: 126, Issue:7

    Topics: Alkenes; Dopamine Agonists; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Quinolones; Receptors, Dopamine D1; Stereoisomerism; Thiophenes

2004
Exploring the boundaries of a light-driven molecular motor design: new sterically overcrowded alkenes with preferred direction of rotation.
    Organic & biomolecular chemistry, 2004, May-21, Volume: 2, Issue:10

    Topics: Alkenes; Circular Dichroism; Crystallography, X-Ray; Cyclization; Heterocyclic Compounds, 3-Ring; Hot Temperature; Hydrazones; Isomerism; Light; Models, Molecular; Molecular Conformation; Naphthalenes; Nitriles; Photochemistry; Piperidines; Rotation; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfhydryl Compounds; Sulfur Compounds; Thermodynamics

2004
Elimination-addition mechanism for nucleophilic substitution reaction of cyclohexenyl iodonium salts and regioselectivity of nucleophilic addition to the cyclohexyne intermediate.
    Journal of the American Chemical Society, 2004, Jun-23, Volume: 126, Issue:24

    Topics: Acetates; Alkenes; Alkynes; Cyclohexanes; Deuterium; Kinetics; Molecular Structure; Onium Compounds; Oxidation-Reduction; Piperidines; Stereoisomerism

2004
Piptigrine, a new insecticidal amide from Piper nigrum Linn.
    Natural product research, 2004, Volume: 18, Issue:5

    Topics: Alkenes; Amides; Humans; Insecticides; Phytotherapy; Piper nigrum; Piperidines; Seeds

2004
Tandem overman rearrangement and intramolecular amidomercuration reactions. stereocontrolled synthesis of cis- and trans-2,6-dialkylpiperidines.
    Organic letters, 2004, Sep-02, Volume: 6, Issue:18

    Topics: Alkaloids; Alkenes; Catalysis; Indicators and Reagents; Mercury; Molecular Structure; Piperidines; Stereoisomerism

2004
Design of a nonreductive method for chemoselective cleavage of hydrazines in the presence of unsaturations: application to a stereoconvergent three-component synthesis of (-)-methyl palustramate.
    The Journal of organic chemistry, 2004, Nov-26, Volume: 69, Issue:24

    Topics: Acids; Alkenes; Hydrazines; Molecular Conformation; Oxidation-Reduction; Piperidines; Stereoisomerism

2004
Biomimetic total synthesis of (+)-himbacine.
    Organic letters, 2005, Feb-17, Volume: 7, Issue:4

    Topics: 4-Butyrolactone; Aldehydes; Alkaloids; Alkenes; Furans; Models, Molecular; Naphthalenes; Piperidines; Stereoisomerism; Trifluoroacetic Acid

2005
Piperidinyl amides with insecticidal activity from the maritime plant Otanthus maritimus.
    Journal of agricultural and food chemistry, 2005, Mar-09, Volume: 53, Issue:5

    Topics: Alkenes; Amides; Animals; Ants; Asteraceae; Insecticides; Isoptera; Oils, Volatile; Piperidines; Plant Extracts

2005
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Alkenes; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Stability; Models, Molecular; Nitriles; Peptides; Piperidines; Protease Inhibitors; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship

2005
Tandem double-intramolecular [4+2]/[3+2] cycloadditions of nitroalkenes. Studies toward a total synthesis of daphnilactone B: piperidine ring construction.
    The Journal of organic chemistry, 2006, Jan-20, Volume: 71, Issue:2

    Topics: Alkaloids; Alkenes; Lactones; Models, Molecular; Molecular Conformation; Piperidines

2006
Synthesis of 3,4-disubstituted piperidines by carbonyl ene and prins cyclizations: switching between kinetic and thermodynamic control with Brønsted and Lewis acid catalysts.
    The Journal of organic chemistry, 2006, Mar-17, Volume: 71, Issue:6

    Topics: Alkenes; Aluminum; Catalysis; Cyclization; Kinetics; Organometallic Compounds; Piperidines; Stereoisomerism; Thermodynamics

2006
Asymmetric synthesis of highly substituted azapolycyclic compounds via 2-alkenyl sulfoximines: potential scaffolds for peptide mimetics.
    Journal of the American Chemical Society, 2006, Mar-29, Volume: 128, Issue:12

    Topics: Aldehydes; Alkenes; Biomimetic Materials; Methionine; Models, Molecular; Peptides; Piperidines; Polycyclic Compounds; Pyrrolidines; Stereoisomerism

2006
Stereocontrolled synthesis of the D- and L-glycero-beta-D-manno-heptopyranosides and their 6-deoxy analogues. Synthesis of methyl alpha-l-rhamno-pyranosyl-(1-->3)-D-glycero-beta-D-manno-heptopyranosyl- (1-->3)-6-deoxy-glycero-beta-D-manno-heptopyranosyl-(
    Journal of the American Chemical Society, 2006, Jun-21, Volume: 128, Issue:24

    Topics: Acetals; Alkenes; Azo Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Deoxy Sugars; Glycosylation; Heptoses; Lipopolysaccharides; Mesylates; Methylglycosides; Models, Chemical; Molecular Sequence Data; Nitriles; Oligosaccharides; Piperidines; Plesiomonas; Rhamnose; Stereoisomerism; Sulfinic Acids; Trialkyltin Compounds

2006
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.
    Bioorganic & medicinal chemistry, 2006, Dec-01, Volume: 14, Issue:23

    Topics: Adenosine Monophosphate; Alkenes; Allosteric Regulation; Binding Sites; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Phosphorylase; Glycogenolysis; Hepatocytes; Humans; Piperidines; Purine Nucleosides

2006
Hydroaminomethylation with novel rhodium-carbene complexes: an efficient catalytic approach to pharmaceuticals.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:5

    Topics: Alkenes; Amines; Catalysis; Hydrocarbons; Imidazoles; Ligands; Methane; Methylation; Models, Chemical; Molecular Structure; Organometallic Compounds; Pharmaceutical Preparations; Piperidines; Propane; Rhodium; Styrenes

2007
Pyrrolidine and piperidine formation via copper(II) carboxylate-promoted intramolecular carboamination of unactivated olefins: diastereoselectivity and mechanism.
    The Journal of organic chemistry, 2007, May-11, Volume: 72, Issue:10

    Topics: Alkenes; Amination; Carboxylic Acids; Copper; Crystallography, X-Ray; Cyclization; Free Radicals; Models, Molecular; Molecular Structure; Nitrogen; Oxidation-Reduction; Piperidines; Pyrrolidines; Solvents; Stereoisomerism; Sulfonamides; Temperature; Water

2007
Efficient enantioselective synthesis of piperidines through catalytic asymmetric ring-opening/cross-metathesis reactions.
    Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:24

    Topics: Alkenes; Catalysis; Molybdenum; Piperidines; Ruthenium; Stereoisomerism

2007
Regio- and stereoselective cross-coupling of substituted olefins and imines. A convergent stereoselective synthesis of saturated 1,5-amino-alcohols and substituted piperidines.
    Journal of the American Chemical Society, 2007, Jun-20, Volume: 129, Issue:24

    Topics: Alkenes; Amino Alcohols; Imines; Molecular Biology; Piperidines

2007
An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems.
    Organic letters, 2007, Jul-05, Volume: 9, Issue:14

    Topics: Alkenes; Cyclization; Cyclopentanes; Indicators and Reagents; Isoxazoles; Nitro Compounds; Piperidines

2007
[4 + 2] cycloadditions of N-alkenyl iminium ions: structurally complex heterocycles from a three-component Diels-Alder reaction sequence.
    Journal of the American Chemical Society, 2008, Jul-23, Volume: 130, Issue:29

    Topics: Alkenes; Cyclization; Imines; Indoles; Piperidines

2008
Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats.
    The Journal of toxicological sciences, 2009, Volume: 34, Issue:1

    Topics: Administration, Oral; Alanine Transaminase; Alkaloids; Alkenes; Animals; Benzodioxoles; Body Weight; Cholesterol, HDL; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Glutathione; Lipoproteins, LDL; Male; Medicine, Ayurvedic; Motor Activity; Piper; Piperidines; Plant Preparations; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Sex Factors; Sleep Stages; Time Factors; Toxicity Tests, Acute; Zingiber officinale

2009
Stereocontrol in N-directed hydroboration: synthesis of amino alcohols related to the piperidine alkaloids.
    Organic letters, 2009, Mar-05, Volume: 11, Issue:5

    Topics: Alkaloids; Alkenes; Amino Alcohols; Boranes; Catalysis; Heterocyclic Compounds, Bridged-Ring; Models, Molecular; Molecular Structure; Piperidines; Stereoisomerism

2009
One-pot asymmetric synthesis of substituted piperidines by exocyclic chirality induction.
    Organic letters, 2009, Jun-04, Volume: 11, Issue:11

    Topics: Alkenes; Amines; Catalysis; Ketones; Molecular Structure; Piperidines; Stereoisomerism

2009
Substitution effect on the cylization/fluorination reaction of N-dienes in superacid.
    The Journal of organic chemistry, 2009, Aug-21, Volume: 74, Issue:16

    Topics: Alkenes; Antimony; Cyclization; Fluorides; Halogenation; Halogens; Hydrofluoric Acid; Nitrogen; Piperidines

2009
Formation of medium-sized nitrogen heterocycles from gamma-silyloxy-gamma-lactams.
    The Journal of organic chemistry, 2009, Sep-18, Volume: 74, Issue:18

    Topics: Alkaloids; Alkenes; Heterocyclic Compounds; Lactams; Models, Chemical; Nitrogen; Piperidines; Silanes; Siloxanes; Stereoisomerism

2009
Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Alkenes; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Ketones; Piperidines

2009
Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.
    The Journal of organic chemistry, 2009, Oct-02, Volume: 74, Issue:19

    Topics: Alkenes; Catalysis; Diamines; Molecular Structure; Palladium; Piperidines; Stereoisomerism

2009
Preparation of enantiopure substituted piperidines containing 2-alkene or 2-alkyne chains: application to total syntheses of natural quinolizidine-alkaloids.
    The Journal of organic chemistry, 2010, Mar-19, Volume: 75, Issue:6

    Topics: Alkaloids; Alkenes; Alkynes; Heterocyclic Compounds, 2-Ring; Molecular Structure; Piperidines; Quinolizidines; Quinolizines; Stereoisomerism

2010
Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids.
    Organic & biomolecular chemistry, 2010, Apr-21, Volume: 8, Issue:8

    Topics: Alkaloids; Alkenes; Alkynes; Indolizidines; Piperidines; Stereoisomerism

2010
Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.
    The Journal of biological chemistry, 2010, Dec-24, Volume: 285, Issue:52

    Topics: Alkaloids; Alkenes; Animals; Furans; Glutamic Acid; Mice; Mice, Knockout; Muscarinic Agonists; Naphthalenes; Oxotremorine; Parasympatholytics; Piperidines; Posterior Horn Cells; Receptors, Muscarinic; Spinal Cord; Synapses; Synaptic Transmission

2010
NMR evidence of the kinetic and thermodynamic products in the NIS promoted cyclization of 1-phenyl-4-pentenylamines. Synthesis and reactivity of trans-2-phenyl-5-iodopiperidines.
    Chemical communications (Cambridge, England), 2011, Mar-21, Volume: 47, Issue:11

    Topics: Alkenes; Amines; Cyclization; Deuterium; Kinetics; Magnetic Resonance Spectroscopy; Piperidines; Thermodynamics

2011
Gold(I)-catalyzed intramolecular amination of allylic alcohols with alkylamines.
    Organic letters, 2011, Mar-18, Volume: 13, Issue:6

    Topics: Alkenes; Amination; Amines; Catalysis; Combinatorial Chemistry Techniques; Cyclization; Gold; Piperidines; Propanols; Pyrrolidines; Stereoisomerism

2011
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans.
    Nature medicine, 2011, Jun-19, Volume: 17, Issue:7

    Topics: Acetylcholine; Alkenes; Animals; Dose-Response Relationship, Drug; Glucagon-Secreting Cells; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Physostigmine; Piperidines; Receptors, Cholinergic; Secretory Vesicles; Signal Transduction; Vesicular Acetylcholine Transport Proteins

2011
Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti.
    Natural product research, 2012, Volume: 26, Issue:22

    Topics: Aedes; Alkaloids; Alkenes; Amides; Animals; Benzodioxoles; Culex; Fatty Acids, Unsaturated; Female; Heterocyclic Compounds, 2-Ring; Insecticides; Male; Piper nigrum; Piperidines; Polyunsaturated Alkamides

2012
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
    The Journal of organic chemistry, 2012, Feb-03, Volume: 77, Issue:3

    Topics: Acetyl-CoA Carboxylase; Alkenes; Alkylation; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Indazoles; Ketones; Piperidines; Pyrazoles; Stereoisomerism; Substrate Specificity

2012
Activation of remote meta-C-H bonds assisted by an end-on template.
    Nature, 2012, Jun-27, Volume: 486, Issue:7404

    Topics: Alkenes; Carbon; Chemistry Techniques, Synthetic; Ethers, Cyclic; Hydrogen; Nitriles; Phenylpropionates; Piperidines; Toluene

2012
Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.
    Organic letters, 2012, Sep-07, Volume: 14, Issue:17

    Topics: Alkenes; Amino Acids; Aspartic Acid; Catalysis; Glutamic Acid; Molecular Structure; Nitro Compounds; Piperidines; Pyrrolidines; Stereoisomerism; Thiourea

2012
Metal-free intramolecular aminofluorination of alkenes mediated by PhI(OPiv)2/hydrogen fluoride-pyridine system.
    Organic & biomolecular chemistry, 2012, Nov-21, Volume: 10, Issue:43

    Topics: Alkenes; Cyclization; Hydrofluoric Acid; Iodine; Molecular Structure; Piperidines; Pyridines; Stereoisomerism; Vinyl Compounds

2012
Arylation, alkenylation, and alkylation of 2-halopyridine N-oxides with grignard reagents: a solution to the problem of C2/C6 regioselective functionalization of pyridine derivatives.
    The Journal of organic chemistry, 2013, Mar-15, Volume: 78, Issue:6

    Topics: Alkenes; Alkylation; Catalysis; Cyclic N-Oxides; Flavanones; Indicators and Reagents; Molecular Structure; Naphthyridines; Piperazines; Piperidines; Pyridines; Pyridones; Stereoisomerism

2013
Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
    Cell biochemistry and function, 2014, Volume: 32, Issue:1

    Topics: Acute Disease; Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Female; Fruit; Gout Suppressants; Indomethacin; Inflammation; Lipid Peroxidation; Male; Piper; Piperidines; Rats; Rats, Wistar; Uric Acid; Zingiber officinale

2014
The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine.
    Organic & biomolecular chemistry, 2013, Jul-07, Volume: 11, Issue:25

    Topics: Alkenes; Free Radicals; Imines; Paroxetine; Photolysis; Piperidines; Quantum Theory; Selective Serotonin Reuptake Inhibitors; Thermodynamics; Water

2013
Trikatu, an herbal compound as immunomodulatory and anti-inflammatory agent in the treatment of rheumatoid arthritis--an experimental study.
    Cellular immunology, 2014, Volume: 287, Issue:1

    Topics: Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Female; Hemolytic Plaque Technique; Herbal Medicine; Hypersensitivity, Delayed; Immunity, Cellular; Immunity, Humoral; Immunomodulation; Indomethacin; Inflammation Mediators; Interleukin-1beta; Macrophages; Phagocytosis; Piperidines; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2014
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice.
    Pharmacological research, 2014, Volume: 80

    Topics: Alkenes; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Catalepsy; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acid-Binding Proteins; Glycerides; Heterocyclic Compounds, 2-Ring; Humans; Hypothermia; Locomotion; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Neoplasm Proteins; Piper; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Serine Endopeptidases; Structure-Activity Relationship; U937 Cells

2014
Pd-N-heterocyclic carbene catalyzed synthesis of piperidine alkene-alkaloids and their anti-cancer evaluation.
    Bioorganic & medicinal chemistry letters, 2014, Feb-15, Volume: 24, Issue:4

    Topics: Alkaloids; Alkenes; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; MCF-7 Cells; Methane; Molecular Conformation; Organometallic Compounds; Palladium; Piperidines; Structure-Activity Relationship

2014
Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu--a Rasayana from Indian Ayurveda.
    Journal of ethnopharmacology, 2014, May-14, Volume: 153, Issue:3

    Topics: Alkenes; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Herb-Drug Interactions; Microsomes, Liver; Piperidines; Rats

2014
Two-chamber hydrogen generation and application: access to pressurized deuterium gas.
    The Journal of organic chemistry, 2014, Jun-20, Volume: 79, Issue:12

    Topics: Alkenes; Alkynes; Catalysis; Deuterium; Dioxanes; Dioxoles; Hydrogen; Isotope Labeling; Kinetics; Metals; Oxidation-Reduction; Phthalazines; Piperazines; Piperidines; Quinolines

2014
Lewis base catalyzed, enantioselective, intramolecular sulfenoamination of olefins.
    Journal of the American Chemical Society, 2014, Jun-25, Volume: 136, Issue:25

    Topics: Alkenes; Amination; Azepines; Catalysis; Lewis Bases; Molecular Structure; Piperidines; Pyrrolidines; Stereoisomerism

2014
CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes.
    Scientific reports, 2014, Jun-24, Volume: 4

    Topics: Alkenes; Cell Differentiation; Cell Hypoxia; Cells, Cultured; Chemokine CCL2; Chromosomal Proteins, Non-Histone; Fibroblast Growth Factor 2; Gene Expression; Homeodomain Proteins; Humans; Immunoblotting; Immunohistochemistry; Induced Pluripotent Stem Cells; Janus Kinase 1; Janus Kinases; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Nanog Homeobox Protein; Phosphorylation; Piperidines; Pluripotent Stem Cells; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stage-Specific Embryonic Antigens; STAT3 Transcription Factor

2014
Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.
    The Journal of comparative neurology, 2015, Apr-01, Volume: 523, Issue:5

    Topics: Alkenes; Animals; Axons; Blotting, Western; Brain; Disease Models, Animal; Epilepsy; Humans; Immunohistochemistry; Interneurons; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Mutation; Piperidines; Voltage-Gated Sodium Channel beta-1 Subunit

2015
Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes.
    Organic & biomolecular chemistry, 2015, Jan-28, Volume: 13, Issue:4

    Topics: Alkaloids; Alkenes; Benzodioxoles; Chemistry Techniques, Synthetic; Ligands; Piperidines; Polyunsaturated Alkamides; Receptors, GABA-A; TRPV Cation Channels

2015
Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats.
    International journal of rheumatic diseases, 2017, Volume: 20, Issue:3

    Topics: Alkenes; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Female; Freund's Adjuvant; Joints; Male; Piperidines; Plant Extracts; Rats, Wistar

2017
Zn-catalyzed enantio- and diastereoselective formal [4 + 2] cycloaddition involving two electron-deficient partners: asymmetric synthesis of piperidines from 1-azadienes and nitro-alkenes.
    Journal of the American Chemical Society, 2015, Apr-08, Volume: 137, Issue:13

    Topics: Alkenes; Amides; Catalysis; Cycloaddition Reaction; Electrons; Ligands; Nitro Compounds; Piperidines; Stereoisomerism; Zinc

2015
Preparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF.
    Organic letters, 2015, Aug-21, Volume: 17, Issue:16

    Topics: Alkenes; Catalysis; Cyclization; Halogenation; Hydrocarbons, Fluorinated; Indicators and Reagents; Molecular Structure; Piperidines; Stereoisomerism

2015
A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes.
    Journal of the American Chemical Society, 2015, Nov-04, Volume: 137, Issue:43

    Topics: Alkenes; Allyl Compounds; Boranes; Catalysis; Copper; Molecular Structure; Organometallic Compounds; Palladium; Piperidines; Stereoisomerism

2015
Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars.
    Organic letters, 2015, Dec-18, Volume: 17, Issue:24

    Topics: Alkenes; Azides; Catalysis; Cyclization; Cycloaddition Reaction; Glycosides; Imino Pyranoses; Molecular Conformation; Molecular Structure; Piperidines; Stereoisomerism

2015
Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons.
    Journal of neurochemistry, 2016, Volume: 137, Issue:2

    Topics: Alkenes; Animals; Bicuculline; Cerebellum; Cholinergic Agents; Drug Interactions; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gene Expression Regulation; Male; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Piperidines; Pirenzepine; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Vestibular Nuclei

2016
Pd(II)-Catalyzed Aminofluorination of Alkenes in Total Synthesis 6-(R)-Fluoroswainsonine and 5-(R)-Fluorofebrifugine.
    Organic letters, 2016, Mar-04, Volume: 18, Issue:5

    Topics: Alkaloids; Alkenes; Catalysis; Molecular Structure; Palladium; Piperidines; Pyridines; Quinazolines; Stereoisomerism; Swainsonine

2016
EFFECT OF TRIKATU, AN AYURVEDIC PRESCRIPTION ON THE PHARMACOKINETIC PROFILE OF CARBAMAZEPINE IN RABBITS.
    Indian journal of physiology and pharmacology, 1999, Volume: 43, Issue:1

    Topics: Alkenes; Animals; Area Under Curve; Carbamazepine; Drug Interactions; Male; Medicine, Ayurvedic; Piperidines; Rabbits

1999
Trikatu, an herbal compound ameliorates rheumatoid arthritis by the suppression of inflammatory immune responses in rats with adjuvant-induced arthritis and on cultured fibroblast like synoviocytes via the inhibition of the NFκB signaling pathway.
    Chemico-biological interactions, 2016, Oct-25, Volume: 258

    Topics: Alkenes; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fluorescent Antibody Technique; Gas Chromatography-Mass Spectrometry; Inflammation; Inflammation Mediators; Male; NF-kappa B; Phytotherapy; Piperidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Synovial Membrane; Synoviocytes

2016
Anti-
    Natural product research, 2019, Volume: 33, Issue:23

    Topics: Acyclic Monoterpenes; Alkenes; Anti-Infective Agents; Apiaceae; Distillation; Escherichia coli; Gas Chromatography-Mass Spectrometry; Hemlock; Microbial Sensitivity Tests; Oils, Volatile; Piperidines; Plant Leaves; Pseudomonas aeruginosa; Sicily

2019
Deconstructive diversification of cyclic amines.
    Nature, 2018, Volume: 564, Issue:7735

    Topics: Alkenes; Amines; Carbon; Chlorine; Cyclization; Nitrogen; Peptides; Piperidines; Proline; Pyrrolidines

2018
Mechanism of Ni-Catalyzed Reductive 1,2-Dicarbofunctionalization of Alkenes.
    Journal of the American Chemical Society, 2019, 11-06, Volume: 141, Issue:44

    Topics: Alkenes; Catalysis; Cyclization; Cyclopentanes; Free Radicals; Furans; Models, Chemical; Nickel; Oxidation-Reduction; Piperidines; Pyrrolidines; Zinc

2019
Oxyamination of Unactivated Alkenes with Electron-Rich Amines and Acids via a Catalytic Triiodide Intermediate.
    Organic letters, 2020, 02-07, Volume: 22, Issue:3

    Topics: Alkenes; Amination; Amines; Carboxylic Acids; Catalysis; Copper; Dioxoles; Electrons; Iodides; Molecular Structure; Oxidation-Reduction; Piperidines; Stereoisomerism

2020
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.
    Molecules (Basel, Switzerland), 2020, May-22, Volume: 25, Issue:10

    Topics: Alkenes; Carbon; Molecular Structure; Nitrogen Oxides; Organophosphonates; Piperidines; Pyrroles; Stereoisomerism

2020
Effects of Desilication in NaOH/Piperidine Medium and Phosphorus Modification on the Catalytic Activity of HZSM-5 Catalyst in Methanol to Propylene Conversion.
    Combinatorial chemistry & high throughput screening, 2021, Volume: 24, Issue:4

    Topics: Alkenes; Catalysis; Crystallization; Hot Temperature; Kinetics; Methanol; Microwaves; Phosphorus; Piperidines; Porosity; Quaternary Ammonium Compounds; Silicon Dioxide; Sodium Hydroxide; Zeolites

2021
Spice-infused palmyra palm syrup improved cell-mediated immunity in Wistar Albino rats.
    Journal of food biochemistry, 2020, Volume: 44, Issue:11

    Topics: Alkenes; Animals; Arecaceae; COVID-19; Humans; Immunity, Cellular; Piperidines; Rats, Wistar; SARS-CoV-2; Self Care; Spices

2020
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines.
    Nature chemistry, 2022, Volume: 14, Issue:10

    Topics: Agrochemicals; Alkenes; Amination; Amines; Catalysis; Lewis Bases; Ligands; Oxidative Stress; Palladium; Pharmaceutical Preparations; Piperidines

2022