alkenes has been researched along with paclitaxel in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 11 (31.43) | 29.6817 |
| 2010's | 19 (54.29) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Croteau, R; Hezari, M; Lewis, NG | 1 |
| Croteau, R; Hezari, M; Koepp, AE; LaFever, RE; Lewis, NG; Vogel, BS; Zajicek, J | 1 |
| Croteau, R; Gibson, DM; Hefner, J; Ketchum, RE; Rubenstein, SM; Williams, RM | 1 |
| Carroll, BJ; Coates, RM; Croteau, R; Floss, HG; Jin, Q; Lenger, SR; Rithner, CD; Williams, DC; Williams, RM | 1 |
| Mamer, O; Sauriol, F; Sun, DA; Zamir, LO | 1 |
| Croteau, R; Huang, Q; Roessner, CA; Scott, AI | 1 |
| Dai, J; Guo, D; Guo, H; Hu, Q; Ye, M; Zhang, D; Zheng, J; Zhu, W | 1 |
| Croteau, R; Jennewein, S; Long, RM; Williams, RM | 1 |
| Besumbes, O; Boronat, A; Imperial, S; Phillips, MA; Rodríguez-Concepción, M; Sauret-Güeto, S | 1 |
| Herbette, G; Lesot, A; Onillon, S; Rontein, D; Sallaud, C; Tissier, A; Werck-Reichhart, D | 1 |
| Aldegunde, MJ; Castedo, L; Granja, JR | 1 |
| Jennewein, S; Schmeer, H | 1 |
| Khosla, C; Liu, T | 1 |
| Ajikumar, PK; Leonard, E; Mucha, O; Pfeifer, B; Phon, TH; Simeon, F; Stephanopoulos, G; Tyo, KE; Wang, Y; Xiao, WH | 1 |
| Christianson, DW; Coates, RM; Croteau, R; Jin, Y; Köksal, M | 1 |
| Chen, X; Dai, J; Xie, D; Yin, D; Zhang, Y; Zou, J | 1 |
| Baek, KH; Cha, M; Kim, OT; Kim, SH; Kwon, SY; Lee, SW; Shim, SH | 1 |
| Cheng, KD; Guo, L; Huang, SQ; Kong, JQ; Wang, W; Yang, Y; Zheng, XD | 1 |
| Chen, G; Chen, L; Chen, YL; Gao, L; Gu, X; Liu, X; Shen, J; Wang, X; Xi, W; Xiong, B; You, Q | 1 |
| Baek, KH; Hasan, MM; Jeon, JH; Kim, HS; Kim, SH; Moon, B; Shim, SH; Song, JY | 1 |
| Baran, PS; Isomura, M; Mendoza, A; Wilde, NC | 1 |
| Jiang, F; Li, M; Miao, Z; Yu, X | 1 |
| Bai, XY; Jiang, RW; Lü, JM; Zhang, W; Zhou, YY; Zhu, ZR | 1 |
| Guo, L; Lin, J; Xin, Y; Yang, H; Ye, Z; You, L | 1 |
| Edgar, S; King, JR; Qiao, K; Simpson, JH; Stephanopoulos, G; Zhou, K | 1 |
| Ajikumar, PK; Arnold, W; Biggs, BW; Das, A; De Mey, M; Kambalyal, A; Lim, CG; O'Neil-Johnson, M; Rouck, JE; Starks, CM | 1 |
| Li, J; Mutanda, I; Wang, J; Wang, K; Wang, Y; Yang, L | 1 |
| De La Peña, R; Sattely, ES | 1 |
| Lungang, L; Nowrouzi, B; Rios-Solis, L | 1 |
| Dai, JG; Guo, DA; Guo, HZ; Han, J; Hu, Q; Ye, M; Zhang, DY; Zheng, JH; Zhu, WH | 1 |
| Fray, RG; Hayes, CJ; Kovacs, K; Linforth, RS; Whittaker, B; Zhang, L | 1 |
| Anterola, A; Perroud, PF; Quatrano, R; Shanle, E | 1 |
| Liang, JY; Liu, MZ; Qu, W; Sun, JB; Wang, MH; Wu, FH; Zhou, ZH | 1 |
| Soliman, S; Tang, Y | 1 |
| Anterola, AM; Sagwan-Barkdoll, L | 1 |
1 review(s) available for alkenes and paclitaxel
| Article | Year |
|---|---|
[The advance in synthetic biology: towards a microbe-derived paclitaxel intermediates].
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Biosynthetic Pathways; Diterpenes; Escherichia coli; Fermentation; Metabolic Engineering; Paclitaxel; Prodrugs; Saccharomyces cerevisiae; Synthetic Biology | 2013 |
34 other study(ies) available for alkenes and paclitaxel
| Article | Year |
|---|---|
Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis.
Topics: Alkenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Chromatography; Diterpenes; Electrophoresis, Polyacrylamide Gel; Isomerases; Magnesium; Paclitaxel; Plant Leaves; Plant Stems; Plants, Medicinal; Polyisoprenyl Phosphates; Species Specificity | 1995 |
Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew.
Topics: Alkenes; Diterpenes; Magnetic Resonance Spectroscopy; Molecular Structure; Paclitaxel; Polyisoprenyl Phosphates; Trees | 1995 |
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis.
Topics: Alkenes; Catalysis; Cells, Cultured; Cytochrome P-450 Enzyme System; Diterpenes; Hydroxylation; Oxygen; Paclitaxel | 1996 |
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Cations; Cyclization; Deuterium; Diterpenes; Isomerases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Structure; Paclitaxel; Plants, Medicinal; Polyisoprenyl Phosphates; Protons; Recombinant Proteins; Taxus | 2000 |
Biotransformation of a 4(20),11(12)-taxadiene derivative.
Topics: Alkenes; Antineoplastic Agents; Biotransformation; Bridged-Ring Compounds; Cunninghamella; Diterpenes; Fungi; Hydroxylation; Magnetic Resonance Spectroscopy; Paclitaxel; Stereoisomerism; Substrate Specificity; Taxoids | 2001 |
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol.
Topics: Alkenes; Alkyl and Aryl Transferases; Antineoplastic Agents; Carbon-Carbon Double Bond Isomerases; Diterpenes; Escherichia coli; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Hemiterpenes; Isomerases; Oxidoreductases; Paclitaxel; Transferases; Transformation, Genetic | 2001 |
Substrate specificity for the hydroxylation of polyoxygenated 4(20),11-taxadienes by Ginkgo cell suspension cultures.
Topics: Alkenes; Biotransformation; Bridged-Ring Compounds; Cells, Cultured; Diterpenes; Ginkgo biloba; Hydroxylation; Molecular Structure; Paclitaxel; Plants, Medicinal; Substrate Specificity; Taxoids | 2003 |
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.
Topics: Alkenes; Amino Acid Sequence; Catalysis; Cytochrome P-450 Enzyme System; Diterpenes; Isomerases; Kinetics; Mixed Function Oxygenases; Molecular Sequence Data; Oxidation-Reduction; Oxygenases; Paclitaxel; Saccharomyces cerevisiae; Sequence Alignment; Taxoids; Taxus | 2004 |
Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol.
Topics: Alkenes; Arabidopsis; Diterpenes; Gene Expression Regulation; Isomerases; Paclitaxel; Plant Proteins; Plants, Genetically Modified; Polyisoprenyl Phosphates; Recombinant Proteins; Taxus | 2004 |
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Catalysis; Cytochrome P-450 Enzyme System; Diterpenes; Hydroxylation; Isomerases; Microsomes; Nicotiana; Oxidation-Reduction; Paclitaxel; Plant Proteins; Plants, Genetically Modified; Saccharomyces cerevisiae; Taxoids | 2008 |
Synthesis of 2-ene-1,4-diols by a new cascade-opening of 1,3-diepoxides: towards an efficient synthesis of dihydroxytaxoid derivatives.
Topics: Alcohols; Alkenes; Epoxy Compounds; Hydroxylation; Paclitaxel; Taxoids; Titanium | 2009 |
Biocatalytic synthesis of tritium ((3)H)-labelled taxa-4(5),11(12)-diene, the pathway committing precursor of the taxoid diterpenoids.
Topics: Alkenes; Biocatalysis; Blotting, Western; Cloning, Molecular; Diterpenes; Gas Chromatography-Mass Spectrometry; Genetic Engineering; Genetic Vectors; Isomerases; Paclitaxel; Pichia; Staining and Labeling; Taxoids; Taxus; Tritium | 2010 |
Chemistry. A balancing act for Taxol precursor pathways in E. coli.
Topics: Alkenes; Diterpenes; Escherichia coli; Farnesyltranstransferase; Fermentation; Genetic Engineering; Glucose; Hemiterpenes; Isomerases; Metabolic Networks and Pathways; NADPH-Ferrihemoprotein Reductase; Organophosphorus Compounds; Paclitaxel; Recombinant Fusion Proteins; Taxus | 2010 |
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.
Topics: Alkenes; Bioreactors; Cytochrome P-450 Enzyme System; Diterpenes; Erythritol; Escherichia coli K12; Farnesyltranstransferase; Fermentation; Genetic Engineering; Hemiterpenes; Indoles; Isomerases; Metabolic Networks and Pathways; Metabolomics; NADPH-Ferrihemoprotein Reductase; Organophosphorus Compounds; Oxidation-Reduction; Paclitaxel; Recombinant Fusion Proteins; Sugar Phosphates; Taxoids; Taxus; Terpenes | 2010 |
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Topics: Alkenes; Amino Acid Motifs; Amino Acid Sequence; Biocatalysis; Catalytic Domain; Crystallization; Crystallography, X-Ray; Diterpenes; Evolution, Molecular; Isomerases; Models, Molecular; Organophosphates; Paclitaxel; Polyisoprenyl Phosphates; Protein Folding; Taxus; Terpenes | 2011 |
Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Biotransformation; Cell Line, Tumor; Cells, Cultured; Diterpenes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ginkgo biloba; Humans; Paclitaxel | 2011 |
Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene.
Topics: Alkenes; Cells, Cultured; Diterpenes; Isomerases; Linoleic Acids; Paclitaxel; Panax; Plant Cells; Plant Roots | 2012 |
Direct glycosylation of bioactive small molecules with glycosyl iodide and strained olefin as acid scavenger.
Topics: Alkenes; Benzimidazoles; Docetaxel; Glycosides; Glycosylation; Iodides; Paclitaxel; Stereoisomerism; Taxoids | 2014 |
Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene.
Topics: Acetates; Alkenes; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cyclopentanes; Diterpenes; Gene Silencing; Humans; Isomerases; Metabolic Engineering; Metabolic Networks and Pathways; Nicotiana; Oxylipins; Paclitaxel; Plant Growth Regulators; Polyisoprenyl Phosphates; Taxoids; Taxus | 2014 |
Two-phase synthesis of (-)-taxuyunnanine D.
Topics: Alkenes; Biological Products; Diterpenes; Models, Molecular; Oxidation-Reduction; Paclitaxel; Taxus | 2014 |
Engineering isoprenoid biosynthesis in Artemisia annua L. for the production of taxadiene: a key intermediate of taxol.
Topics: Alkenes; Antineoplastic Agents; Artemisia annua; Diterpenes; Humans; Metabolic Engineering; Paclitaxel; Plant Leaves; Plants, Genetically Modified; Polyisoprenyl Phosphates; Terpenes | 2015 |
[Chemical constituents of Taxus chinensis var. mairei cell cultures].
Topics: Alkenes; Cell Culture Techniques; Cells, Cultured; Diterpenes; Molecular Structure; Paclitaxel; Sitosterols; Taxoids; Taxus | 2015 |
[Combinational expression of geranylgeranyl diphosphate synthase and taxadiene synthase in Coprinopsis cinerea].
Topics: Agaricales; Alkenes; Diterpenes; Farnesyltranstransferase; Genetic Engineering; Isomerases; Paclitaxel; Plasmids | 2015 |
Mechanistic Insights into Taxadiene Epoxidation by Taxadiene-5α-Hydroxylase.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Diterpenes; Epoxy Compounds; Isomerism; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Paclitaxel; Taxus | 2016 |
Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Diterpenes; Escherichia coli; Fermentation; Metabolic Engineering; Models, Molecular; Oxidation-Reduction; Paclitaxel; Substrate Specificity; Taxus | 2016 |
Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana.
Topics: Alkenes; Chloroplasts; Cytochrome P-450 Enzyme System; Diterpenes; Genetic Vectors; Isomerases; Metabolic Engineering; NADPH-Ferrihemoprotein Reductase; Nicotiana; Paclitaxel; Taxoids; Taxus; Terpenes | 2019 |
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation.
Topics: Alkenes; Arabidopsis; Chloroplasts; Colforsin; Cytosol; Diterpenes; Lactones; Mevalonic Acid; Nicotiana; Oryza; Paclitaxel; Plant Leaves; Plant Roots; Plants; Signal Transduction | 2021 |
Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae.
Topics: Alkenes; Aminolevulinic Acid; Antioxidants; Bridged-Ring Compounds; Cytochrome P-450 Enzyme System; Diterpenes; Epoxy Compounds; Flavin-Adenine Dinucleotide; Hemin; Iron; Paclitaxel; Saccharomyces cerevisiae; Taxoids | 2022 |
Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum.
Topics: Alkenes; Biotransformation; Cells, Cultured; Diterpenes; Humans; Phytotherapy; Platycodon; Spectrophotometry, Infrared; Structure-Activity Relationship; Taxus | 2003 |
Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit.
Topics: Alkenes; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Base Sequence; Carotenoids; Diterpenes; DNA, Plant; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Isomerases; Magnetic Resonance Spectroscopy; Plants, Genetically Modified; Solanum lycopersicum; Taxus | 2007 |
Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens.
Topics: Alkenes; Biotechnology; Bryopsida; Diterpenes; Isomerases; Plants, Genetically Modified; Taxus | 2009 |
A new taxane diterpenoid from Taxus chinensis var. mairei.
Topics: Alkenes; Diterpenes; Drugs, Chinese Herbal; Flavonoids; Nuclear Magnetic Resonance, Biomolecular; Taxoids; Taxus | 2014 |
Natural and engineered production of taxadiene with taxadiene synthase.
Topics: Alkenes; Catalytic Domain; Diterpenes; Escherichia coli; Fungal Proteins; Isomerases; Metabolic Engineering; Taxus | 2015 |
Taxadiene-5α-ol is a minor product of CYP725A4 when expressed in Escherichia coli.
Topics: Alkenes; Cytochrome P-450 Enzyme System; Diterpenes; Escherichia coli; Taxus | 2018 |