Compounds > alkenes
Page last updated: 2024-08-23

alkenes and fostriecin

alkenes has been researched along with fostriecin in 82 studies

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-199010 (12.20)18.7374
1990's31 (37.80)18.2507
2000's40 (48.78)29.6817
2010's1 (1.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Darzynkiewicz, Z; Hotz, MA; Traganos, F1
Frosina, G; Rossi, O1
Darzynkiewicz, Z; Del Bino, G; Hotz, MA; Lassota, P; Traganos, F1
de Jong, S; de Vries, EG; Mulder, NH; Zijlstra, JG1
Stĕtina, R; Veselá, D1
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA1
Collins, AR; Gedik, CM1
Hawkins, KL; Pegg, DG; Susick, RL1
Fritz-Niggli, H; Rao, KR1
Baguley, BC; Calveley, SB; Crowe, KK; Fray, LM; O'Rourke, SA; Smith, GP1
Besserer, JA; Boritzki, TJ; Fry, DW; Jackson, RC; Wolfard, TS1
Clark, GM; Elslager, EF; Scheithauer, W; Shillis, JL; Von Hoff, DD1
Mamber, SW; Okasinski, WG; Pinter, CD; Tunac, JB1
Boritzki, TJ; Fry, DW; Hook, KE; Jackson, RC; Leopold, WR; Roberts, BJ1
Jackson, RC; Leopold, WR; Mertus, AE; Nelson, JM; Roberts, BJ; Shillis, JL1
Besserer, JA; Boritzki, TJ; Fry, DW1
Boritzki, TJ; Fry, DW; Jackson, RC1
Dobson, WE; Graham, BD; Tunac, JB1
Brankiewicz, AJ; Bunge, RH; French, JC; Hurley, TR; Smitka, TA; Stampwala, SS; Steinman, CE; Willmer, NE1
Brigle, KE; Goldman, ID; Sierra, EE; Spinella, MJ1
Anderson, HJ; Bradbury, EM; Guo, XW; Roberge, M; Swank, RA; Th'ng, JP; Tudan, C1
Anderson, H; Harder, KW; Hung, SM; Jirik, FR; Roberge, M; Tudan, C1
Moore, MJ; Pillon, L; Thiessen, JJ1
Berney, JJ; Chresta, CM; Delgado, C; Francis, GE; Patel, P; Tejedor, MC1
Ahmed, T; Bigman, K; Darzynkiewicz, Z; Gong, J; Gorczyca, W; Melamed, MR; Mittelman, A1
Ho, DT; Roberge, M1
Allan, WP; Fattman, CL; Hasinoff, BB; Yalowich, JC1
Anderson, H; Roberge, M1
de Jong, RS; de Vries, EG; Mulder, NH1
Cheng, A; Honkanen, RE; Walsh, AH1
Armstrong, SC; Downey, JM; Ganote, CE; Gao, W; Honkanen, RE; Kao, R; Shivell, LC1
Armstrong, SC; Ganote, CE; Gao, W; Lane, JR1
de Jong, PE; de Jong, RS; de Vries, EG; Meijer, S; Mulder, NH1
Nishito, Y; Usui, H1
Takai, A1
Cohen, PT; Hastie, CJ1
Balczon, R; Cheng, A; Honkanen, RE; Koons, JS; Walsh, AH; Zuo, Z1
Armstrong, SC; Baines, CP; Cohen, MV; Downey, JM; Ganote, CE; Honkanen, RE; Liu, GS; Walsh, AH; Weinbrenner, C1
O'Connor, PM; Orlandi, L; Orr, MS; Piwnica-Worms, H; Sausville, EA; Senderowicz, AM; Silvestrini, R; Wang, P; Watanabe, N; Yu, L1
de Jong, RS; de Vries, EG; Groen, HJ; Höppener, FJ; Mulder, NH; Sleijfer, DT; Uges, DR; van der Graaf, WT; Willemse, PH1
Barik, S; Connor, JH; Honkanen, RE; Kleeman, T; Shenolikar, S1
Darzynkiewicz, Z; Juan, G; Traganos, F1
Borthwick, EB; Cohen, PT; Prescott, AR; Zeke, T1
Douglas, P; Lees-Miller, SP; Moorhead, GB; Ye, R1
Evans, DR; Simon, JA1
BouzBouz, S; Cossy, J; Pradaux, F1
Boger, DL; Ichikawa, S; Zhong, W1
Biade, S; Boyd, JT; Chapman, JD; Stobbe, CC1
Bastan, R; Peachell, PT; Peirce, MJ1
McCluskey, A; Sakoff, JA; Sim, AT1
Falck, JR; Reddy, YK1
Ikejiri, M; Imanishi, T; Kawasaki, H; Maemura, S; Miyashita, K2
Farndale, RW; Sundaresan, P1
Boger, DL; Gauss, CM; Lewy, DS; Soenen, DR1
Kobayashi, Y; Wang, YG1
Bock, PJ; Faulkner, NE; Lane, BR; Markovitz, DM1
Esumi, T; Hatakeyama, S; Okamoto, N1
Fujii, K; Kanai, M; Maki, K; Shibasaki, M1
Fandrich, RR; Jeyaraman, M; Kardami, E; Lukas, A; Tanguy, S1
Göke, B; Groblewski, GE; Krzykowski, KJ; Schäfer, C; Steffen, H1
Brown, HC; Liu, H; Ram Reddy, MV; Ramachandran, PV1
Boger, DL; Bonness, KM; Buck, SB; Gauss, CM; Hardouin, C; Honkanen, RE; Hwang, I; Ichikawa, S; Soenen, DR; Swingle, MR1
Day, A; Eisenhauer, EA; Erlichman, C; Lê, LH; Moore, MJ; Pillon, L; Thiessen, JJ; Wainman, N1
Jacobsen, EN; Taylor, MS1
Frederiksen, MU; Harrington, PE; Papillon, JP; Shin, S; Shireman, BT; Trost, BM1
Grethe, S; Pörn-Ares, MI1
Ballard, DW; Carter, RS; Gomez, RJ; Khan, WN; Kray, AE; Llanes, JM; Pennington, KN; Sanders, LE; Wadzinski, BE1
Fujii, K; Kanai, M; Kobayashi, T; Maki, K; Motoki, R; Shibasaki, M; Tamura, S1
Boynton, A; Messner, DJ; Romeo, C; Rossie, S1
Fang, L; Willis, WD; Wu, J; Zhang, X1
Li, Z; Tu, X; Wang, CC1
Amable, L; Boga, SB; Boger, DL; Colby, DA; Gauss, CM; Honkanen, RE; Lawhorn, BG; Swingle, MR; Wolkenberg, SE1
Hayashi, Y; Okado, K; Shoji, M; Toyo, T; Toyoshima, M; Yamaguchi, H1
Hosokawa, T; Ikejiri, M; Imanishi, T; Miyashita, K; Tsunemi, T1
Alhamadsheh, MM; Palaniappan, N; Reynolds, KA1
Amable, L; Boger, DL; Buck, SB; Burke, CP; Fischer, KL; Honkanen, RE; Lawhorn, BG; Ratti, P; Swingle, MR1
Hatakeyama, S; Ishihara, J; Sarkar, SM; Shibahara, S; Takahashi, K; Wanzala, EN1
Ishi, K; Kuramochi, K; Kusayanagi, T; Sugawara, F; Takahashi, N; Takeuchi, T1
McDonald, FE; Robles, O1
Hanaoka, F; Hirano, T; Ikehara, T; Imamoto, N; Imamura, S; Kimura, K; Maeshima, K; Murayama, A; Takemoto, A; Watanabe, Y; Yamaguchi, K; Yanagisawa, J; Yokoyama, S1
Brindle, CS; Knopf, JD; Trost, BM1

Reviews

7 review(s) available for alkenes and fostriecin

ArticleYear
Fostriecin: a review of the preclinical data.
    Anti-cancer drugs, 1997, Volume: 8, Issue:5

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Humans; Polyenes; Pyrones

1997
[The structure and regulatory mechanisms of protein phosphatase 2A].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1998, Volume: 43, Issue:8 Suppl

    Topics: Alkenes; Animals; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Histone Chaperones; Humans; Methylation; Phosphoprotein Phosphatases; Phosphorylation; Polyamines; Polyelectrolytes; Polyenes; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Proteins; Pyrones; Transcription Factors

1998
[Naturally occurring toxins with specific inhibitory activity against protein serine/threonine phosphatases 1 and 2A].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1998, Volume: 43, Issue:8 Suppl

    Topics: Alkenes; Animals; Antifungal Agents; Cantharidin; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Spiro Compounds

1998
Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
    Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6

    Topics: Alkenes; Antibiotics, Antineoplastic; Antifungal Agents; Cantharidin; Crystallography, X-Ray; Cyclosporine; Enzyme Inhibitors; Humans; Microcystins; Models, Molecular; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Spiro Compounds; Structure-Activity Relationship

2002
Fostriecin: chemistry and biology.
    Current medicinal chemistry, 2002, Volume: 9, Issue:22

    Topics: Alkenes; Antineoplastic Agents; Enzyme Inhibitors; Humans; Phosphoprotein Phosphatases; Polyenes; Protein Phosphatase 2; Pyrones; Structure-Activity Relationship; Topoisomerase II Inhibitors

2002
Asymmetric catalysis in complex target synthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Apr-13, Volume: 101, Issue:15

    Topics: Alkaloids; Alkenes; Alprostadil; Catalysis; Chemistry, Organic; Furans; Hexoses; Lactones; Organic Chemicals; Oxazoles; Polyenes; Pyrans; Pyrones; Spiro Compounds; Stereoisomerism

2004
Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.
    Chemical reviews, 2016, Dec-28, Volume: 116, Issue:24

    Topics: Alkenes; Biological Products; Cyclization; Cycloaddition Reaction; Hydroxylation; Lactones; Polyenes; Pyrones; Stereoisomerism

2016

Trials

2 trial(s) available for alkenes and fostriecin

ArticleYear
Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.
    British journal of cancer, 1999, Volume: 79, Issue:5-6

    Topics: Adult; Aged; Alanine Transaminase; Alkenes; Antibiotics, Antineoplastic; Aspartate Aminotransferases; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Half-Life; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Polyenes; Pyrones; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1999
Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days.
    Investigational new drugs, 2004, Volume: 22, Issue:2

    Topics: Adult; Aged; Alkenes; Analysis of Variance; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Injections, Intravenous; Linear Models; Male; Middle Aged; Polyenes; Pyrones

2004

Other Studies

73 other study(ies) available for alkenes and fostriecin

ArticleYear
Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation.
    Experimental cell research, 1992, Volume: 201, Issue:1

    Topics: Acridine Orange; Alkenes; Cell Death; Cell Line; Cell Nucleus; Chromatin; G2 Phase; Humans; Leukemia; Polyenes; Pyrones; S Phase; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Effect of topoisomerase poisoning by antitumor drugs VM 26, fostriecin and camptothecin on DNA repair replication by mammalian cell extracts.
    Carcinogenesis, 1992, Volume: 13, Issue:8

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Camptothecin; Cell Extracts; Cricetinae; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; In Vitro Techniques; Polyenes; Pyrones; Teniposide

1992
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
    Cancer research, 1992, Mar-15, Volume: 52, Issue:6

    Topics: Alkenes; Amsacrine; Antibiotics, Antineoplastic; Cell Cycle; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Leukemia, Promyelocytic, Acute; Polyenes; Pyrones; Teniposide; Tumor Cells, Cultured

1992
Lack of cross-resistance to fostriecin in a human small-cell lung carcinoma cell line showing topoisomerase II-related drug resistance.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:6

    Topics: Alkenes; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Cell Line; Cell Nucleus; DNA Topoisomerases, Type II; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Humans; Lung Neoplasms; Methotrexate; Polyenes; Pyrones; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1991
The influence of DNA-topoisomerase II inhibitors novobiocin and fostriecin on the induction and repair of DNA damage in Chinese hamster ovary (CHO) cells treated with mitoxantrone.
    Neoplasma, 1991, Volume: 38, Issue:1

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Female; Mitoxantrone; Novobiocin; Ovary; Polyenes; Pyrones; Topoisomerase II Inhibitors

1991
Comparative toxicity of fostriecin, hepsulfam and pyrazine diazohydroxide to human and murine hematopoietic progenitor cells in vitro.
    Investigational new drugs, 1991, Volume: 9, Issue:2

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Drugs, Investigational; Hematopoietic Stem Cells; Humans; Mice; Polyenes; Pyrazines; Pyrones; Sulfonic Acids

1991
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells.
    Nucleic acids research, 1990, Feb-25, Volume: 18, Issue:4

    Topics: Alkenes; Antibiotics, Antineoplastic; Camptothecin; Cell Membrane Permeability; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Kinetics; Novobiocin; Polyenes; Pyrones; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Ultraviolet Rays

1990
Preclinical toxicological evaluation of fostriecin, a novel anticancer antibiotic, in rats.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 15, Issue:2

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Blood Cell Count; Drug Evaluation, Preclinical; Female; Injections, Intravenous; Kidney Diseases; Male; Organ Size; Polyenes; Pyrones; Rats; Rats, Inbred Strains

1990
Response of murine small intestine to combined treatment with fostriecin and X rays.
    The British journal of radiology, 1990, Volume: 63, Issue:748

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Cell Survival; Dose-Response Relationship, Radiation; Female; Intestine, Small; Jejunum; Mice; Mice, Inbred Strains; Polyenes; Pyrones; Radiation-Sensitizing Agents; Streptomycin

1990
Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:2

    Topics: Alkaloids; Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flavonoids; Harringtonines; Homoharringtonine; Mice; Mice, Inbred Strains; Polyenes; Pyrones; Tumor Necrosis Factor-alpha

1989
Inhibition of type II topoisomerase by fostriecin.
    Biochemical pharmacology, 1988, Nov-01, Volume: 37, Issue:21

    Topics: Adenosine Triphosphate; Alkenes; Animals; Cell Cycle; Cell Line; DNA Damage; DNA, Mitochondrial; In Vitro Techniques; Mice; Polyenes; Pyrones; Topoisomerase II Inhibitors

1988
In vitro activity of the novel antitumor antibiotic fostriecin (CI-920) in a human tumor cloning assay.
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:8

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Humans; In Vitro Techniques; Mice; Neoplasms; Polyenes; Pyrones; Tumor Stem Cell Assay

1986
Antimycotic effects of the novel antitumor agents fostriecin (CI-920), PD 113,270 and PD 113,271.
    The Journal of antibiotics, 1986, Volume: 39, Issue:10

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Antifungal Agents; Candida; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Microbial Sensitivity Tests; Mitosporic Fungi; Polyenes; Pyrones; Saccharomyces

1986
The biochemical pharmacology of CI-920, a structurally novel antibiotic with antileukemic activity.
    Advances in enzyme regulation, 1985, Volume: 23

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Flow Cytometry; Folic Acid; Leukemia L1210; Mice; Neoplasms, Experimental; Nucleotides; Polyenes; Pyrones; Structure-Activity Relationship

1985
Anticancer activity of the structurally novel antibiotic Cl-920 and its analogues.
    Cancer research, 1984, Volume: 44, Issue:5

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Drug Administration Schedule; Drug Evaluation, Preclinical; Leukemia L1210; Mice; Neoplasms, Experimental; Polyenes; Pyrones; Structure-Activity Relationship

1984
Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Alkenes; Animals; Biological Transport; Drug Resistance; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Polyenes; Pyrones; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

1984
Studies on the biochemical mechanism of the novel antitumor agent, CI-920.
    Cancer chemotherapy and pharmacology, 1984, Volume: 13, Issue:3

    Topics: Alkenes; Animals; Antineoplastic Agents; Cells, Cultured; Deoxyribonucleosides; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, Neoplasm; Leukemia L1210; Mice; Neoplasm Proteins; Polyenes; Pyrones; Ribonucleosides; RNA, Neoplasm; Templates, Genetic

1984
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties.
    The Journal of antibiotics, 1983, Volume: 36, Issue:12

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Fermentation; Leukemia L1210; Leukemia P388; Mice; Microbial Sensitivity Tests; Polyenes; Pyrones; Streptomyces; Structure-Activity Relationship

1983
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization.
    The Journal of antibiotics, 1983, Volume: 36, Issue:12

    Topics: Alkenes; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Fermentation; Magnetic Resonance Spectroscopy; Polyenes; Pyrones; Spectrophotometry; Streptomyces; Structure-Activity Relationship

1983
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
    The Journal of biological chemistry, 1995, Apr-07, Volume: 270, Issue:14

    Topics: Alkenes; Animals; Biological Transport; Carrier Proteins; Energy Metabolism; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Ions; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyenes; Probenecid; Pyrones; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Temperature; Transfection; Tumor Cells, Cultured

1995
Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.
    The EMBO journal, 1995, Mar-01, Volume: 14, Issue:5

    Topics: Alkaloids; Alkenes; Animals; CDC2 Protein Kinase; Chromosomes; Cyclins; Ethers, Cyclic; G2 Phase; Genes, cdc; Histones; Mice; Mitosis; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protamine Kinase; Protein Kinase C; Protein Phosphatase 1; Pyrones; Staurosporine; Temperature; Tumor Cells, Cultured

1995
Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A.
    Cancer research, 1994, Dec-01, Volume: 54, Issue:23

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Camptothecin; CDC2 Protein Kinase; Cells, Cultured; Cricetinae; DNA Damage; DNA Replication; G2 Phase; Mitosis; Phosphoprotein Phosphatases; Polyenes; Protein Phosphatase 1; Protein Phosphatase 2; Pyrones; Teniposide

1994
Determination of fostriecin pharmacokinetics in plasma using high-pressure liquid chromatography assay.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:2

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Drug Stability; Injections, Intravenous; Male; Polyenes; Pyrones; Rabbits; Sensitivity and Specificity

1994
Effects of DNA topoisomerase II inhibitors on human bone marrow progenitor cells.
    Leukemia, 1994, Volume: 8, Issue:1

    Topics: Adult; Alkenes; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Drug Screening Assays, Antitumor; Etoposide; Hematopoietic Stem Cells; Humans; Polyenes; Pyrones; Thiobarbiturates; Topoisomerase II Inhibitors

1994
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.
    Leukemia, 1993, Volume: 7, Issue:5

    Topics: Adult; Aged; Alkenes; Antineoplastic Agents; Apoptosis; Camptothecin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Gamma Rays; Humans; In Vitro Techniques; Leukemia; Male; Middle Aged; Polyenes; Pyrones; Tumor Cells, Cultured

1993
The antitumor drug fostriecin induces vimentin hyperphosphorylation and intermediate filament reorganization.
    Carcinogenesis, 1996, Volume: 17, Issue:5

    Topics: Alkaloids; Alkenes; Animals; Antibiotics, Antineoplastic; CDC2 Protein Kinase; Cells, Cultured; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Intermediate Filaments; Molecular Weight; Phosphorylation; Polyenes; Protein Kinase C; Pyrones; Staurosporine; Vimentin

1996
Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells.
    Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4

    Topics: Alkenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Leukemia; Polyenes; Pyrones; Razoxane; Thiobarbiturates

1996
Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:1

    Topics: Aclarubicin; Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle Proteins; Cell Line; Chromosomes; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; G2 Phase; Guanine Nucleotide Exchange Factors; Kidney; Mitosis; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Pyrones; Razoxane; Temperature; Thiobarbiturates; Topoisomerase II Inhibitors

1996
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
    FEBS letters, 1997, Oct-27, Volume: 416, Issue:3

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Brain; Cattle; Enzyme Inhibitors; Isoenzymes; Kinetics; Muscle, Skeletal; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylase Kinase; Polyenes; Pyrones; Rabbits; Recombinant Fusion Proteins

1997
Comparison of in vitro preconditioning responses of isolated pig and rabbit cardiomyocytes: effects of a protein phosphatase inhibitor, fostriecin.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:11

    Topics: Alkenes; Animals; Enzyme Inhibitors; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Myocardium; Phosphoprotein Phosphatases; Polyenes; Pyrones; Rabbits; Swine

1997
Protein phosphatase inhibitors calyculin A and fostriecin protect rabbit cardiomyocytes in late ischemia.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:1

    Topics: Adenosine Triphosphate; Alkenes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ischemic Preconditioning, Myocardial; Marine Toxins; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; Naphthalenes; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Kinase C; Pyrones; Rabbits

1998
Renal toxicity of the anticancer drug fostriecin.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:2

    Topics: Adult; Aged; Alkenes; Antibiotics, Antineoplastic; Creatine; Electrolytes; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Neoplasms; Polyenes; Pyrones; Renal Plasma Flow, Effective; Urea

1998
Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.
    FEBS letters, 1998, Jul-24, Volume: 431, Issue:3

    Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Carcinogens; Chromosome Mapping; Chromosomes, Human, Pair 16; Enzyme Inhibitors; Humans; Hybrid Cells; Male; Phosphoprotein Phosphatases; Polyenes; Pyrones; Rabbits; Swine; Testis

1998
Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity.
    Cancer research, 1998, Aug-15, Volume: 58, Issue:16

    Topics: Alkenes; Animals; Antineoplastic Agents; Cantharidin; Centrosome; CHO Cells; Cricetinae; Enzyme Inhibitors; G2 Phase; Mitosis; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Pyrones; RNA, Messenger; Spindle Apparatus; Tumor Suppressor Protein p53

1998
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia.
    Circulation, 1998, Sep-01, Volume: 98, Issue:9

    Topics: Alkenes; Animals; Coronary Circulation; Enzyme Inhibitors; Female; Ischemic Preconditioning, Myocardial; Male; Muscle Fibers, Skeletal; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyrones; Rabbits

1998
UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
    The Journal of biological chemistry, 1998, Dec-11, Volume: 273, Issue:50

    Topics: Alkaloids; Alkenes; Amino Acid Sequence; Animals; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Mice; Molecular Sequence Data; Nuclear Proteins; Polyenes; Protein-Tyrosine Kinases; Pyrones; Staurosporine; Tumor Cells, Cultured

1998
Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.
    The Journal of biological chemistry, 1999, Aug-06, Volume: 274, Issue:32

    Topics: Alkenes; Amino Acid Sequence; Antifungal Agents; Enzyme Activation; Enzyme Inhibitors; Humans; Microcystins; Models, Molecular; Molecular Sequence Data; Peptides, Cyclic; Phosphoprotein Phosphatases; Polyenes; Protein Binding; Protein Phosphatase 1; Protein Structure, Secondary; Proteins; Pyrans; Pyrones; Sequence Homology, Amino Acid; Spiro Compounds

1999
Assaying drug-induced apoptosis.
    Methods in molecular biology (Clifton, N.J.), 2001, Volume: 95

    Topics: Alkenes; Apoptosis; Camptothecin; Cell Size; DNA; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Gamma Rays; HL-60 Cells; Humans; Indoles; Microscopy, Fluorescence; Polyenes; Pyrones; Rhodamines; Topoisomerase I Inhibitors; Ultraviolet Rays

2001
Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region.
    FEBS letters, 2001, Mar-02, Volume: 491, Issue:3

    Topics: Active Transport, Cell Nucleus; Alkenes; Amino Acid Substitution; Antibiotics, Antineoplastic; Bacterial Proteins; Carcinogens; Cell Line; Cell Nucleus; Consensus Sequence; Conserved Sequence; Gene Expression; Genes, Reporter; HeLa Cells; Humans; Luminescent Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphoprotein Phosphatases; Polyenes; Protein Structure, Tertiary; Pyrones; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship

2001
Protein phosphatases regulate DNA-dependent protein kinase activity.
    The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22

    Topics: Alkenes; Antigens, Nuclear; Catalysis; Catalytic Domain; Cell Line; Cells, Cultured; DNA Damage; DNA Helicases; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Ku Autoantigen; Microcystins; Nuclear Proteins; Okadaic Acid; Peptides, Cyclic; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Precipitin Tests; Protein Binding; Protein Kinases; Protein Phosphatase 1; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyrones; Recombinant Proteins; Time Factors

2001
The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin.
    FEBS letters, 2001, Jun-01, Volume: 498, Issue:1

    Topics: Alkenes; Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Cysteine; Humans; Molecular Sequence Data; Phosphoprotein Phosphatases; Polyenes; Protein Structure, Secondary; Pyrones; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine

2001
Synthesis of the C1-C12 fragment of fostriecin.
    Organic letters, 2001, Jul-12, Volume: 3, Issue:14

    Topics: Alkenes; Antibiotics, Antineoplastic; Cyclization; Enzyme Inhibitors; Epoxy Compounds; Molecular Structure; Polyenes; Propanols; Pyrones; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors

2001
Total synthesis of fostriecin (CI-920).
    Journal of the American Chemical Society, 2001, May-09, Volume: 123, Issue:18

    Topics: Alkenes; Antibiotics, Antineoplastic; Polyenes; Pyrones; Streptomyces

2001
Chemical agents that promote chromatin compaction radiosensitize tumour cells.
    International journal of radiation biology, 2001, Volume: 77, Issue:10

    Topics: Alkenes; Cell Survival; Chromatin; Histones; HT29 Cells; Humans; Hydroxamic Acids; Immunohistochemistry; Neoplasms; Okadaic Acid; Polyenes; Pyrones; Radiation Tolerance

2001
Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung.
    European journal of pharmacology, 2001, Oct-26, Volume: 430, Issue:1

    Topics: Alkenes; Antifungal Agents; Basophils; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Lung; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Skin; Spiro Compounds

2001
Asymmetric total synthesis of (+)-fostriecin.
    Organic letters, 2002, Mar-21, Volume: 4, Issue:6

    Topics: Alkenes; Enzyme Inhibitors; Phosphoprotein Phosphatases; Polyenes; Pyrones

2002
Total synthesis of fostriecin (CI-920) via a convergent route.
    Chemical communications (Cambridge, England), 2002, Apr-07, Issue:7

    Topics: Alkenes; Antibiotics, Antineoplastic; Enzyme Inhibitors; Esters; Malates; Polyenes; Pyrones; Stereoisomerism

2002
P38 mitogen-activated protein kinase dephosphorylation is regulated by protein phosphatase 2A in human platelets activated by collagen.
    FEBS letters, 2002, Sep-25, Volume: 528, Issue:1-3

    Topics: Alkenes; Animals; Blood Platelets; Carrier Proteins; Cattle; Collagen; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Polyenes; Protein Phosphatase 2; Pyrones

2002
Formal total synthesis of fostriecin.
    Organic letters, 2002, Dec-26, Volume: 4, Issue:26

    Topics: Alcohols; Alkenes; Antibiotics, Antineoplastic; Enzyme Inhibitors; Ketones; Magnesium; Polyenes; Pyrones

2002
Protein phosphatase 2A enhances activation of human immunodeficiency virus type 1 by phorbol myristate acetate.
    Journal of virology, 2003, Volume: 77, Issue:3

    Topics: Alkenes; HIV-1; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Promoter Regions, Genetic; Protein Kinase C; Protein Phosphatase 2; Pyrones; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells; Virus Activation

2003
Versatile enantiocontrolled synthesis of (+)-fostriecin.
    Chemical communications (Cambridge, England), 2002, Dec-21, Issue:24

    Topics: Alkenes; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Phosphoprotein Phosphatases; Polyenes; Pyrones; Stereoisomerism; Streptomyces

2002
Formal catalytic asymmetric total synthesis of fostriecin.
    Organic letters, 2003, Mar-06, Volume: 5, Issue:5

    Topics: Alkenes; Antibiotics, Antineoplastic; Catalysis; Polyenes; Pyrones; Streptomyces

2003
Ischemia-induced dephosphorylation of cardiomyocyte connexin-43 is reduced by okadaic acid and calyculin A but not fostriecin.
    Molecular and cellular biochemistry, 2003, Volume: 242, Issue:1-2

    Topics: Alkenes; Animals; Blotting, Western; Cells, Cultured; Connexin 43; Gap Junctions; Gene Expression; Ischemia; Marine Toxins; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley

2003
CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:4

    Topics: Alkenes; Animals; Binding Sites; Calcineurin Inhibitors; Calcium; Cholecystokinin; Cyclic AMP; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors

2003
Total synthesis of an antitumor antibiotic, Fostriecin (CI-920).
    Journal of the American Chemical Society, 2003, Jul-09, Volume: 125, Issue:27

    Topics: Alkenes; Antibiotics, Antineoplastic; Polyenes; Pyrones

2003
Synthesis of homoallylic chiral tertiary alcohols via chelation-controlled diastereoselective nucleophilic addition on alpha-alkoxyketones: application for the synthesis of the C(1)-C(11) subunit of 8-epi-fostriecin.
    Organic letters, 2003, Oct-02, Volume: 5, Issue:20

    Topics: Alkenes; Chelating Agents; Ketones; Polyenes; Propanols; Pyrones; Stereoisomerism

2003
Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.
    Journal of the American Chemical Society, 2003, Dec-24, Volume: 125, Issue:51

    Topics: Alkenes; Amino Acid Sequence; Enzyme Inhibitors; Lactones; Molecular Sequence Data; Phosphoprotein Phosphatases; Polyenes; Pyrones; Structure-Activity Relationship

2003
Dinuclear asymmetric Zn aldol additions: formal asymmetric synthesis of fostriecin.
    Journal of the American Chemical Society, 2005, Mar-23, Volume: 127, Issue:11

    Topics: Aldehydes; Alkenes; Antibiotics, Antineoplastic; Enzyme Inhibitors; Organometallic Compounds; Polyenes; Pyrones; Streptomyces; Zinc

2005
p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis.
    Cellular signalling, 2006, Volume: 18, Issue:4

    Topics: Alkenes; Apoptosis; bcl-Associated Death Protein; Cell Line; Cell Survival; Cells, Cultured; Down-Regulation; Endothelial Cells; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyridines; Pyrones; Signal Transduction; Tumor Necrosis Factor-alpha

2006
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
    The Journal of biological chemistry, 2005, Oct-28, Volume: 280, Issue:43

    Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Alkenes; Animals; B-Lymphocytes; Catalysis; Cell Line; Chromatography, Liquid; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Humans; I-kappa B Kinase; Immunoblotting; Immunoprecipitation; Inflammation; Jurkat Cells; Mice; Mice, Inbred C57BL; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyrones; Sepharose; Serine; Signal Transduction; Spleen; Threonine; Time Factors; Transfection; Tumor Necrosis Factor-alpha

2005
Catalyst-controlled asymmetric synthesis of fostriecin and 8-epi-fostriecin.
    Journal of the American Chemical Society, 2005, Dec-07, Volume: 127, Issue:48

    Topics: Alkenes; Antibiotics, Antineoplastic; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Molecular Structure; Phosphoprotein Phosphatases; Polyenes; Pyrones; Streptomyces

2005
Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells.
    Journal of cellular biochemistry, 2006, Sep-01, Volume: 99, Issue:1

    Topics: Alkenes; Amino Acid Sequence; Animals; Antigens, Viral, Tumor; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; G1 Phase; Liver; Molecular Sequence Data; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Protein Phosphatase 2; Pyrones; Rats; RNA, Small Interfering; Tumor Suppressor Protein p53

2006
The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin.
    Molecular pain, 2006, Jul-17, Volume: 2

    Topics: Afferent Pathways; Alkenes; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Male; Nociceptors; Okadaic Acid; Pain; Pain Threshold; Phosphoprotein Phosphatases; Physical Stimulation; Polyenes; Posterior Horn Cells; Pyrones; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission; Time Factors

2006
Okadaic acid overcomes the blocked cell cycle caused by depleting Cdc2-related kinases in Trypanosoma brucei.
    Experimental cell research, 2006, Nov-01, Volume: 312, Issue:18

    Topics: Alkenes; Animals; CDC2 Protein Kinase; Cell Cycle; Enzyme Inhibitors; Humans; Isoenzymes; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Protein Phosphatase 2; Protein Subunits; Protozoan Proteins; Pyrones; RNA Interference; Trypanosoma brucei brucei

2006
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
    Journal of the American Chemical Society, 2006, Dec-27, Volume: 128, Issue:51

    Topics: Alkenes; Animals; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Leukemia L1210; Mice; Models, Molecular; Molecular Conformation; Organophosphates; Phosphoprotein Phosphatases; Polyenes; Pyrones; Stereoisomerism; Structure-Activity Relationship

2006
Formal total synthesis of fostriecin via 1,4-asymmetric induction using cobalt-alkyne complex.
    Organic letters, 2008, Apr-03, Volume: 10, Issue:7

    Topics: Alkenes; Alkynes; Catalysis; Cobalt; Molecular Structure; Polyenes; Pyrones; Stereoisomerism; Streptomyces

2008
Total synthesis of leustroducsin B.
    The Journal of organic chemistry, 2008, Jul-18, Volume: 73, Issue:14

    Topics: Alkenes; Lactones; Molecular Structure; Organophosphorus Compounds; Polyenes; Pyrones; Stereoisomerism

2008
cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.
    Journal of the American Chemical Society, 2008, Sep-17, Volume: 130, Issue:37

    Topics: Alkenes; Hydro-Lyases; Lactones; Multigene Family; Open Reading Frames; Organophosphorus Compounds; Polyenes; Polyketide Synthases; Protein Structure, Tertiary; Pyrones; Streptomyces

2008
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:1

    Topics: Alkenes; Amino Acid Sequence; Animals; Catalytic Domain; Cattle; Enzyme Inhibitors; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Chimeric Proteins; Nuclear Proteins; Organophosphates; Phosphoprotein Phosphatases; Polyenes; Protein Binding; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Pyrones; Rabbits; Structure-Activity Relationship

2009
Enantio- and stereoselective route to the phoslactomycin family of antibiotics: formal synthesis of (+)-fostriecin and (+)-phoslactomycin B.
    Chemical communications (Cambridge, England), 2009, Oct-21, Issue:39

    Topics: Alkenes; Anti-Bacterial Agents; Catalysis; Enzyme Inhibitors; Hydroxyquinolines; Lactones; Organophosphorus Compounds; Polyenes; Protein Phosphatase 1; Pyrones; Quinuclidines; Stereoisomerism

2009
Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells.
    Bioorganic & medicinal chemistry, 2009, Dec-01, Volume: 17, Issue:23

    Topics: Alkenes; Amino Acid Sequence; Antibiotics, Antineoplastic; Binding Sites; Binding, Competitive; Catalytic Domain; Cell Survival; Cysteine; HeLa Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Polyenes; Protein Phosphatase 2; Pyrones; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared

2009
Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation.
    Organic letters, 2009, Dec-03, Volume: 11, Issue:23

    Topics: Alkenes; Catalysis; Molecular Structure; Palladium; Polyenes; Pyrones; Stereoisomerism

2009
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
    Nature structural & molecular biology, 2009, Volume: 16, Issue:12

    Topics: Adenosine Triphosphatases; Alkenes; Animals; Cell Line; Cells, Cultured; Chromosomes; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Kinesins; Models, Biological; Multiprotein Complexes; Okadaic Acid; Polyenes; Protein Phosphatase 2; Pyrones; Xenopus

2009