Page last updated: 2024-08-23

alkenes and ascochlorin

alkenes has been researched along with ascochlorin in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (39.39)	29.6817
2010's	18 (54.55)	24.3611
2020's	2 (6.06)	2.80

Authors

Authors	Studies
Cha, DD; Danheiser, RL; Dudley, GB; Takaki, KS	1
Abe, S; Ando, K; Kuwahara, S; Magae, J; Nishimura, T; Ozawa, S; Tamura, G; Togashi, M; Tsuruga, M; Ubukata, M	1
Boonudomlap, U; Isaka, M; Kittakoop, P; Seephonkai, P; Thebtaranonth, Y	1
Ando, K; Chang, YC; Furukawa, C; Magae, J; Mizuta, N; Nakajima, H; Ozawa, S; Sakaguchi, K; Yamagishi, H	1
Ando, K; Chang, YC; Hong, S; Kim, CH; Kwak, JY; Kwon, TK; Lee, TS; Magae, J; Park, KK	1
Ando, K; Chang, YC; Kim, HS; Kim, KB; Kim, YN; Lee, IK; Lee, KM; Lee, KU; Magae, J; Park, JY; Park, KG	1
Ando, K; Chang, YC; Kang, JH; Kim, CH; Lee, IS; Magae, J; Park, KK	1
Chang, YC; Kang, JH; Kim, CH; Kim, JK; Lee, TS; Magae, J; Nakajima, H; Park, KK; Park, WH	1
Chang, YC; Fujiwara, I; Furukawa, C; Magae, J; Mizuta, M; Mizuta, N; Nakajima, H; Sakaguchi, K	1
Chang, HW; Chang, YC; Furukawa, C; Jeong, JH; Kim, CH; Lee, IS; Magae, J; Min, KS; Nakajima, H; Otsuka, K; Park, KK; Taki, K; Tomita, M	1
Ando, K; Furukawa, C; Kojima, S; Magae, J; Maruyama, A; Shimizu, H; Tsuruga, M	1
Cui, X; Fan, Y; Li, S; Li, Y; Lu, X; Qi, Q; Ren, X; Shi, Y; Zhang, H; Zhao, B; Zheng, Z; Zhu, J	1
Hosono, K; Masuda, S; Ogihara, J; Ohdake, T	1
Berry, EA; Daldal, F; Huang, LS; Lee, DW; Minagawa, N; Nagai, K	1
Chang, YC; Jeong, JH	1
Chang, HW; Chang, YC; Cho, HJ; Chung, IK; Hwang, SL; Jeong, JH; Kang, JH; Kang, SS; Kim, CH; Kim, HD; Magae, J; Min, KS; Park, KK; Park, YY	1
Chang, HW; Chang, YC; Cho, HJ; Chung, IK; Jeong, JH; Jeong, YJ; Kang, JH; Kim, CH; Kim, HT; Moon, YS; Park, KK; Park, YY	1
Chang, HW; Cho, HJ; Chung, IK; Jeong, JH; Jeong, YJ; Kang, JH; Magae, J; Park, KK; Park, YY; Shin, JM	1
Minagawa, N	1
Fukuda, T; Kawaguchi, M; Masuma, R; Nonaka, K; Tomoda, H; Uchida, R	1
Haga, Y; Kido, Y; Kita, K; Saimoto, H; Sakamoto, K	1
Hywel-Jones, NL; Isaka, M; Jennifer Luangsa-Ard, J; Laksanacharoen, P; Supothina, S; Yangchum, A	1
Ahn, KS; Dai, X; Goh, BC; Hui, KM; Kim, C; Kumar, AP; Li, F; Magae, J; Ong, TH; Sethi, G; Shanmugam, MK; Shi, J; Siveen, KS; Wang, LZ	1
Chang, HW; Chang, YC; Chung, TW; Ha, KT; Ha, SH; Kang, BS; Kim, CH; Kwak, CH; Lee, SH; Lee, SK; Lee, YC; Magae, J; Park, J; Suh, SJ	1
Ahn, KS; Arfuso, F; Chang, YC; Dai, X; Deivasigamni, A; Goh, BC; Hui, KM; Kim, C; Kumar, AP; Kumar, D; Kundu, GC; Magae, J; Sethi, G; Um, JY; Wang, LZ	1
Hijikawa, Y; Inaoka, DK; Kido, Y; Kita, K; Matsuzaki, M; Suzuki, S; Tatsumi, R	1
Dai, X; Kumar, AP; Magae, J; Min-Wen, JC; Mishra, S; Sethi, G; Shyh-Chang, N; Yan-Jiang, BC	1
Chang, YC; Cho, HJ; Hoe, HS; Nam, JH; Park, B; Park, JH	1
Abe, I; Awakawa, T; Hu, Y; Quan, Z; Wang, D	1
Abe, I; Araki, Y; Awakawa, T; Cho, R; Hoshino, S; Inaoka, DK; Ito, K; Kido, Y; Kita, K; Matsuda, Y; Matsuzaki, M; Nagamune, K; Shinohara, Y; Yamamoto, M	1
Chang, YC; Chung, TW; Kim, CH; Kim, HD; Kwak, CH; Lee, SH; Lee, YC; Magae, J; Park, J	1
Abe, I; Barra, L	1
Genilloud, O; Kildgaard, S; Larsen, TO; Reyes, F; Subko, K; Vicente, F	1

Reviews

2 review(s) available for alkenes and ascochlorin

Article	Year
Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Advances in protein chemistry and structural biology, 2017, Volume: 108 Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Apoptosis; Ascomycota; Autophagy; Humans; Neoplasm Invasiveness; Neoplasms; Phenols	2017
Chemistry of fungal meroterpenoid cyclases. Natural product reports, 2021, 03-01, Volume: 38, Issue:3 Topics: Alkenes; Biological Products; Carboxy-Lyases; Diterpenes; Fungal Proteins; Phenols; Phylogeny; Pyridines; Pyrones; Sesquiterpenes; Terpenes	2021

Other Studies

31 other study(ies) available for alkenes and ascochlorin

Article	Year
Total synthesis of (-)-ascochlorin via a cyclobutenone-based benzannulation strategy. Organic letters, 2000, Oct-19, Volume: 2, Issue:21 Topics: Alkenes; Cyclobutanes; Phenols; Stereoisomerism	2000
Ascochlorin derivatives as ligands for nuclear hormone receptors. Journal of medicinal chemistry, 2003, Sep-11, Volume: 46, Issue:19 Topics: Alkenes; Animals; Cell Differentiation; Cells, Cultured; Fibroblasts; Furans; Genes, Reporter; Genetic Vectors; Glycolates; Humans; Inhibitory Concentration 50; Ligands; Mice; Models, Molecular; Osteosarcoma; Phenols; Plasmids; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection	2003
A novel ascochlorin glycoside from the insect pathogenic fungus Verticillium hemipterigenum BCC 2370. The Journal of antibiotics, 2004, Volume: 57, Issue:1 Topics: Alkenes; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Chromatography, Gel; Fermentation; Glycosides; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenols; Simplexvirus; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism; Vero Cells; Verticillium	2004
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Biochemical and biophysical research communications, 2005, Apr-01, Volume: 329, Issue:1 Topics: Alkenes; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; DNA Damage; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Luciferases; Phenols; Plasmids; Receptors, Estrogen; Tetrazolium Salts; Thiazoles	2005
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26 Topics: Alkenes; Amino Acid Motifs; Binding, Competitive; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Phenols; Plasmids; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Thioctic Acid; Transcription Factor AP-1; Transcription, Genetic; Transfection	2005
The ascochlorin derivative, AS-6, inhibits TNF-alpha-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells. Life sciences, 2006, Dec-14, Volume: 80, Issue:2 Topics: Adenoviridae; Alkenes; Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Cells, Cultured; Chemokine CCL2; Chemokine CX3CL1; Chemokines, CX3C; Gene Expression; Genetic Vectors; Glycolates; Ligands; Male; Membrane Proteins; Muscle, Smooth, Vascular; NF-kappa B; Phenols; PPAR gamma; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2006
Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS. Journal of proteome research, 2006, Volume: 5, Issue:10 Topics: Alkenes; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Humans; Neoplasm Proteins; Osteosarcoma; Phenols; Proteome; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2006
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages. Journal of cellular biochemistry, 2007, Oct-01, Volume: 102, Issue:2 Topics: Alkenes; Butadienes; Cell Line; Flavonoids; Gene Expression Regulation; Humans; Lipoproteins, LDL; Macrophages; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phenols; Signal Transduction	2007
Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity. The Journal of antibiotics, 2007, Volume: 60, Issue:11 Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Longevity; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Phenols; Proto-Oncogene Proteins c-fos; Receptors, Estrogen; Survival Analysis; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Xenograft Model Antitumor Assays	2007
Ascochlorin activates p53 in a manner distinct from DNA damaging agents. International journal of cancer, 2009, Jun-15, Volume: 124, Issue:12 Topics: Adenosine Triphosphate; Alkenes; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Bone Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Respiration; Checkpoint Kinase 1; Comet Assay; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Fluorescent Antibody Technique; Humans; Mitochondria; Osteosarcoma; Phenols; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sesquiterpenes; Structure-Activity Relationship; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2009
Relationship between peroxisome proliferator-activated receptor-gamma activation and the ameliorative effects of ascochlorin derivatives on type II diabetes. The Journal of antibiotics, 2009, Volume: 62, Issue:7 Topics: Alkenes; Animals; Biotransformation; Blood Glucose; Cell Proliferation; Cholesterol; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Hypoglycemic Agents; Male; Mice; Mice, Knockout; Phenols; Plasmids; PPAR gamma; Receptors, Leptin	2009
[F01WB-1315 A and B, two dihydroorotate dehydrogenase inhibitors from microbial metabolites]. Wei sheng wu xue bao = Acta microbiologica Sinica, 2009, Volume: 49, Issue:4 Topics: Alkenes; Animals; Cell Proliferation; Cells, Cultured; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Fungi; Lymphocytes; Magnetic Resonance Spectroscopy; Mice; Oxidoreductases Acting on CH-CH Group Donors; Phenols; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization	2009
LL-Z1272alpha epoxide, a precursor of ascochlorin produced by a mutant of Ascochyta viciae. The Journal of antibiotics, 2009, Volume: 62, Issue:10 Topics: Alkenes; Ascomycota; Benzaldehydes; Candida albicans; Chemistry, Physical; Culture Media; Epoxy Compounds; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Mutation; Phenols; Sesquiterpenes	2009
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex. Biochimica et biophysica acta, 2010, Volume: 1797, Issue:3 Topics: Alkenes; Animals; Anti-Bacterial Agents; Antimycin A; Catalytic Domain; Cattle; Chickens; Crystallography, X-Ray; Cytochromes b; Cytochromes c; Electron Spin Resonance Spectroscopy; Electron Transport; Electron Transport Complex III; Male; Mitochondria, Liver; Mitochondrial Proteins; Oxidoreductases; Phenols; Pichia; Plant Proteins; Polyenes; Rats; Rats, Wistar; Respiration; Rhodobacter capsulatus; Superoxides; Ubiquinone	2010
Ascochlorin, an isoprenoid antibiotic, induces G1 arrest via downregulation of c-Myc in a p53-independent manner. Biochemical and biophysical research communications, 2010, Jul-16, Volume: 398, Issue:1 Topics: Alkenes; Antibiotics, Antineoplastic; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; G1 Phase; Humans; Phenols; Proto-Oncogene Proteins c-myc; Terpenes; Tumor Suppressor Protein p53	2010
4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1α via AMPK activation. Biochemical and biophysical research communications, 2011, Mar-18, Volume: 406, Issue:3 Topics: Adenosine Triphosphate; Alkenes; AMP-Activated Protein Kinases; Apoptosis; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; Phenols; Promoter Regions, Genetic; Protein Stability; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Terpenes; TOR Serine-Threonine Kinases	2011
Ascochlorin suppresses TGF-β1-induced PAI-1 expression through the inhibition of phospho-EGFR in rat kidney fibroblast cells. Molecular biology reports, 2012, Volume: 39, Issue:4 Topics: Alkenes; Animals; Cell Line; ErbB Receptors; Fibroblasts; Gene Expression Regulation; Kidney; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenols; Phosphorylation; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Protein Kinase Inhibitors; Rats; RNA, Messenger; Transforming Growth Factor beta1	2012
Ascochlorin inhibits growth factor-induced HIF-1α activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells. Journal of cellular biochemistry, 2012, Volume: 113, Issue:4 Topics: Alkenes; Base Sequence; Blotting, Western; Cell Line, Tumor; DNA Primers; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; Phenols; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A	2012
[Mitochondria as targets of chemotherapy]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2012, Volume: 132, Issue:10 Topics: Alkenes; Animals; Anti-Infective Agents; Antimalarials; Atovaquone; Humans; Mitochondria; Phenols; Sesquiterpenes	2012
A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602. The Journal of antibiotics, 2013, Volume: 66, Issue:1 Topics: Alkenes; Anti-Bacterial Agents; Ascomycota; Chromatography, High Pressure Liquid; Culture Media; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Phenols	2013
Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei. Journal of biochemistry, 2013, Volume: 153, Issue:3 Topics: Alkenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Oxidoreductases; Phenols; Protozoan Proteins; Recombinant Proteins; Sesquiterpenes; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosomiasis, African	2013
Ascochlorin derivatives from the leafhopper pathogenic fungus Microcera sp. BCC 17074. The Journal of antibiotics, 2015, Volume: 68, Issue:1 Topics: Alkenes; Animals; Antineoplastic Agents; Cell Line, Tumor; Chlorocebus aethiops; Humans; Hypocreales; Magnetic Resonance Spectroscopy; Neoplasms; Phenols; Vero Cells	2015
Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Molecular oncology, 2015, Volume: 9, Issue:4 Topics: Alkenes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cell Survival; DNA; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Ki-67 Antigen; Liver Neoplasms; Mice; Molecular Chaperones; Neoplasm Invasiveness; Phenols; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Protein Binding; Protein Inhibitors of Activated STAT; Protein Transport; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor	2015
Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway. Journal of cellular biochemistry, 2016, Volume: 117, Issue:4 Topics: Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phenols; Protein Transport; Saccharomycetales; Signal Transduction	2016
Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma. Molecular cancer therapeutics, 2016, Volume: 15, Issue:12 Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; Phenols; Snail Family Transcription Factors; STAT3 Transcription Factor	2016
Re-identification of the ascofuranone-producing fungus Ascochyta viciae as Acremonium sclerotigenum. The Journal of antibiotics, 2017, Volume: 70, Issue:3 Topics: Acremonium; Alkenes; Ascomycota; Fermentation; Phenols; Phylogeny; Sesquiterpenes	2017
Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades. Journal of cellular biochemistry, 2018, Volume: 119, Issue:1 Topics: Alkenes; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Glioblastoma; Humans; Janus Kinase 2; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Proteins; Phenols; Signal Transduction; STAT3 Transcription Factor	2018
Multidomain P450 Epoxidase and a Terpene Cyclase from the Ascochlorin Biosynthetic Pathway in Fusarium sp. Organic letters, 2019, 04-05, Volume: 21, Issue:7 Topics: Alkenes; Biosynthetic Pathways; Fungi; Fusarium; Mixed Function Oxygenases; Molecular Structure; Oxidoreductases; Phenols; Terpenes	2019
Complete biosynthetic pathways of ascofuranone and ascochlorin in Proceedings of the National Academy of Sciences of the United States of America, 2019, 04-23, Volume: 116, Issue:17 Topics: Acremonium; Alkenes; Biosynthetic Pathways; Fungal Proteins; Genes, Fungal; Models, Molecular; Multigene Family; Phenols; Sesquiterpenes	2019
Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages. Journal of ethnopharmacology, 2019, Jul-15, Volume: 239 Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Apoptosis; Caspases; Cell Line, Tumor; Humans; Lipopolysaccharides; Mice; Necrosis; Phenols; RAW 264.7 Cells	2019
Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Marine drugs, 2021, Jan-20, Volume: 19, Issue:2 Topics: Alkenes; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Hypocreales; Phenols; Staphylococcus aureus	2021