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alkenes and 1-cyano-2-hydroxy-3-butene

alkenes has been researched along with 1-cyano-2-hydroxy-3-butene in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.00)18.7374
1990's10 (40.00)18.2507
2000's10 (40.00)29.6817
2010's2 (8.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Crawshaw, J; Jeffery, EH; Kore, AM; Wallig, MA1
Barrowman, JA; Chernenko, G; Maher, M1
Jeffery, EH; Wallig, MA1
Fettman, MJ; Gould, DH; Wallig, MA1
Fettman, MJ; Gould, DH; van Steenhouse, J; Wallig, MA; Willhite, CC1
Borroz, KI; Davis, MA; Eaton, D; Jeffery, EH; Wallig, MA1
Kuchan, MJ; Milner, JA; Wallig, MA1
Davis, MA; Jeffery, EH; Wallig, MA1
Jeffery, E; Kloss, P; Parsons, C; Tumbleson, M; Wallig, M; Zhang, Y1
Jeffery, EH; Kingston, S; Staack, R; Wallig, MA1
Bhatia, M; Frossard, JL; Hofbauer, B; Lee, HS; Saluja, AK; Steer, ML; Wallig, MA1
Jefferey, EH; Kingston, S; Staack, R; Wallig, MA1
Jeffery, E; Nho, CW2
Klein, BP; Niedoborski, TE; Wallig, MA1
Jeffery, EH; Keck, AS; Staack, R1
Epps, DL; Gossman, T; Heinz-Taheny, KM; Wallig, MA1
Adhikari, S; Ang, AD; Bhatia, M; Cao, Y; Clément, MV; Wallig, M1
Mitchell, MD; Thompson, DC; Walgren, JL; Whiteley, LO2
Adhikari, S; Bhatia, M; Cao, Y; Clément, MV; Wallig, M1
Beckonert, O; Bohus, E; Cantor, GH; Coen, M; Ebbels, TM; Holmes, E; Keun, HC; Lindon, JC; Nicholson, JK; Noszál, B; Rácz, A; Wijsman, JA1
Engle, SK; Smith, AT; Sullivan, JM; Usborne, AL; Walgren, JL; Watson, DE1
Bobrowski, W; Brown, TP; Evering, W; Gukasyan, HJ; Hu, W; Huang, W; John-Baptiste, A; Thibault, S; Vitsky, A; Wang, J1
Collett, MG; Matthews, ZM; Parton, KH1

Other Studies

25 other study(ies) available for alkenes and 1-cyano-2-hydroxy-3-butene

ArticleYear
Separation of the toxic and glutathione-enhancing effects of the naturally occurring nitrile, cyanohydroxybutene.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 19, Issue:4

    Topics: Alkenes; Amylases; Animals; Glutathione; Lipase; Male; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344

1992
The acute pancreatotoxic effects of the plant nitrile 1-cyano-2-hydroxy-3-butene.
    Pancreas, 1991, Volume: 6, Issue:2

    Topics: Acute Disease; Alkenes; Animals; Glutathione; Glutathione Transferase; Male; Nitriles; Pancreatic Diseases; Plant Extracts; Rats; Rats, Inbred Strains; Stereoisomerism

1991
Enhancement of pancreatic and hepatic glutathione levels in rats during cyanohydroxybutene intoxication.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 14, Issue:1

    Topics: Alkenes; Animals; Glutathione; Liver; Male; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344

1990
Selective pancreato-toxicity in the rat induced by the naturally occurring plant nitrile 1-cyano-2-hydroxy-3-butene.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1988, Volume: 26, Issue:2

    Topics: Alkenes; Amylases; Animals; Butanols; Glutathione; Male; Nitriles; Pancreas; Plant Extracts; Rats; Seeds; Sulfhydryl Compounds; Thiocyanates

1988
The relationship of vehicle to target organ toxicology induced by the naturally occurring nitrile 1-cyano-2-hydroxy-3-butene.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:3

    Topics: Alkenes; Animals; Corn Oil; Glutathione; Kidney; Liver; Male; Nitriles; Pancreas; Pancreatic Diseases; Pharmaceutical Vehicles; Polysorbates; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiocyanates; Time Factors; Water

1989
Differential effect of cyanohydroxybutene on glutathione synthesis in liver and pancreas of male rats.
    Toxicology and applied pharmacology, 1993, Volume: 123, Issue:2

    Topics: Alkenes; Animals; Base Sequence; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Methionine Sulfoximine; Molecular Sequence Data; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344; RNA, Messenger

1993
Differential effects of cyanohydroxybutene and selenium on normal and neoplastic canine mammary cells in vitro.
    Toxicology letters, 1993, Volume: 69, Issue:1

    Topics: Alkenes; Animals; Cell Survival; Dogs; Glutathione; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Nitriles; Selenium; Sodium Selenite; Tumor Cells, Cultured

1993
In vitro metabolism of cyanohydroxybutene: formation of a glutathione-S-transferase catalyzed product.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 79, Issue:3

    Topics: Alcohol Dehydrogenase; Alkenes; Animals; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytosol; Dipeptides; Glutathione; Glutathione Transferase; Hydroxylation; Male; Microsomes, Liver; Nitriles; Oxidation-Reduction; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Tritium

1993
Studies on the toxic effects of crambe meal and two of its constituents, 1-cyano-2-hydroxy-3-butene (CHB) and epi-progoitrin, in broiler chick diets.
    British poultry science, 1996, Volume: 37, Issue:5

    Topics: Alkenes; Animals; Aspartate Aminotransferases; Chickens; Diet; Dietary Proteins; Eating; Female; Glucosinolates; Glycine max; Kidney; Liver; Male; Nitriles; Pancreas; Plant Proteins; Weight Gain; Zea mays

1996
A comparison of the individual and collective effects of four glucosinolate breakdown products from brussels sprouts on induction of detoxification enzymes.
    Toxicology and applied pharmacology, 1998, Volume: 149, Issue:1

    Topics: Alkenes; Animals; Brassica; Cytochrome P-450 CYP1A1; Enzyme Induction; Glucosinolates; Glutathione Reductase; Glutathione Transferase; Indoles; Isothiocyanates; Liver; Male; NAD(P)H Dehydrogenase (Quinone); Nitriles; Rats; Rats, Inbred F344

1998
Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis.
    Biochemical and biophysical research communications, 1998, May-19, Volume: 246, Issue:2

    Topics: Acute Disease; Alkenes; Amylases; Animals; Apoptosis; Ceruletide; Disease Models, Animal; Female; Mice; Nitriles; Pancreas; Pancreatitis; Rats; Time Factors

1998
Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1998, Volume: 36, Issue:5

    Topics: Alkenes; Animals; Anticarcinogenic Agents; Brassica; Enzyme Induction; Glucosinolates; Glutathione; Glutathione Transferase; Indoles; Isothiocyanates; Male; NAD(P)H Dehydrogenase (Quinone); Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344

1998
The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables.
    Toxicology and applied pharmacology, 2001, Jul-15, Volume: 174, Issue:2

    Topics: Alkenes; Animals; Antioxidants; Drug Interactions; Enzyme Induction; Glucosinolates; Glutathione Transferase; Inactivation, Metabolic; Indoles; Isoenzymes; Male; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Nitriles; Plant Extracts; Rats; RNA, Messenger; Up-Regulation; Vegetables

2001
Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography.
    Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:8

    Topics: Alkenes; Chemoprevention; Chromatography, High Pressure Liquid; Nitriles; Plant Extracts; Seeds; Vegetables

2001
The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture.
    Nutrition and cancer, 2002, Volume: 42, Issue:2

    Topics: Alkenes; Animals; Anticarcinogenic Agents; Cell Cycle; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Isothiocyanates; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Nitriles; Rats; Rats, Inbred F344; Sulfoxides; Thiocyanates

2002
Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol.
    Toxicology and applied pharmacology, 2004, Jul-01, Volume: 198, Issue:1

    Topics: Alkenes; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Enzymologic; Glucosinolates; Hydrolysis; Indoles; Mice; NAD(P)H Dehydrogenase (Quinone); Nitriles; Plant Extracts; Receptors, Aryl Hydrocarbon; Response Elements; RNA, Messenger; Transfection; Up-Regulation

2004
Synergy among phytochemicals within crucifers: does it translate into chemoprotection?
    The Journal of nutrition, 2005, Volume: 135, Issue:12 Suppl

    Topics: Aflatoxin B1; Alkenes; Animals; Antioxidants; Brassicaceae; Diet; Dose-Response Relationship, Drug; Drug Synergism; Indoles; Liver; Male; Neoplasms, Experimental; Nitriles; Plant Preparations; Rats; Rats, Inbred F344

2005
Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 291, Issue:1

    Topics: Alkenes; Animals; Apoptosis; Caspases; Cell Respiration; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Male; Membrane Potentials; Mice; Mitochondria; Nitriles; Pancreas; Signal Transduction

2006
Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 96, Issue:1

    Topics: Acute Disease; Alkenes; Amylases; Animals; Biomarkers; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Lipase; Male; Mice; Nitriles; Pancreas, Exocrine; Pancreatitis; Peptide Fragments; Predictive Value of Tests; Protein Array Analysis; Proteomics; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors

2007
Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 96, Issue:1

    Topics: Acute Disease; Alkenes; Animals; Biomarkers; Cells, Cultured; Cluster Analysis; Disease Models, Animal; Male; Nitriles; Pancreas, Exocrine; Pancreatitis; Peptide Fragments; Peptide Hydrolases; Predictive Value of Tests; Protein Array Analysis; Proteomics; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sequence Analysis, Protein; Serum Albumin; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin

2007
Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways.
    The American journal of pathology, 2007, Volume: 170, Issue:5

    Topics: Alkenes; Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cytokines; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Mice; Nitriles; Pancreatitis, Acute Necrotizing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.
    Magnetic resonance in chemistry : MRC, 2009, Volume: 47 Suppl 1

    Topics: Alkenes; Animals; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Male; Metabolomics; Molecular Structure; Nitriles; Organ Size; Pancreas, Exocrine; Pancreatitis; Rats; Rats, Sprague-Dawley; Reference Standards

2009
Biomarkers of exocrine pancreatic injury in 2 rat acute pancreatitis models.
    Toxicologic pathology, 2014, Volume: 42, Issue:1

    Topics: Acute Disease; Alkenes; Amylases; Animals; Biomarkers; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Exocrine Pancreatic Insufficiency; Lipase; Male; MicroRNAs; Nitriles; Pancreas; Rats; Rats, Sprague-Dawley

2014
Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats.
    Toxicologic pathology, 2017, Volume: 45, Issue:2

    Topics: Acute Disease; Alkenes; Animals; Biomarkers; Ceruletide; Exocrine Pancreatic Insufficiency; Humans; Male; Mice, Inbred C57BL; MicroRNAs; Nitriles; Organ Specificity; Pancreas, Exocrine; Rats, Sprague-Dawley; Rats, Wistar; Sensitivity and Specificity

2017
Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits.
    Toxins, 2020, 11-02, Volume: 12, Issue:11

    Topics: Alkenes; Animals; Biomarkers; Butanols; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glucosinolates; Liver; Male; Necrosis; Nitriles; Pilot Projects; Rabbits; Risk Assessment; Toxicity Tests

2020