alkenes has been researched along with 1-cyano-2-hydroxy-3-butene in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crawshaw, J; Jeffery, EH; Kore, AM; Wallig, MA | 1 |
| Barrowman, JA; Chernenko, G; Maher, M | 1 |
| Jeffery, EH; Wallig, MA | 1 |
| Fettman, MJ; Gould, DH; Wallig, MA | 1 |
| Fettman, MJ; Gould, DH; van Steenhouse, J; Wallig, MA; Willhite, CC | 1 |
| Borroz, KI; Davis, MA; Eaton, D; Jeffery, EH; Wallig, MA | 1 |
| Kuchan, MJ; Milner, JA; Wallig, MA | 1 |
| Davis, MA; Jeffery, EH; Wallig, MA | 1 |
| Jeffery, E; Kloss, P; Parsons, C; Tumbleson, M; Wallig, M; Zhang, Y | 1 |
| Jeffery, EH; Kingston, S; Staack, R; Wallig, MA | 1 |
| Bhatia, M; Frossard, JL; Hofbauer, B; Lee, HS; Saluja, AK; Steer, ML; Wallig, MA | 1 |
| Jefferey, EH; Kingston, S; Staack, R; Wallig, MA | 1 |
| Jeffery, E; Nho, CW | 2 |
| Klein, BP; Niedoborski, TE; Wallig, MA | 1 |
| Jeffery, EH; Keck, AS; Staack, R | 1 |
| Epps, DL; Gossman, T; Heinz-Taheny, KM; Wallig, MA | 1 |
| Adhikari, S; Ang, AD; Bhatia, M; Cao, Y; Clément, MV; Wallig, M | 1 |
| Mitchell, MD; Thompson, DC; Walgren, JL; Whiteley, LO | 2 |
| Adhikari, S; Bhatia, M; Cao, Y; Clément, MV; Wallig, M | 1 |
| Beckonert, O; Bohus, E; Cantor, GH; Coen, M; Ebbels, TM; Holmes, E; Keun, HC; Lindon, JC; Nicholson, JK; Noszál, B; Rácz, A; Wijsman, JA | 1 |
| Engle, SK; Smith, AT; Sullivan, JM; Usborne, AL; Walgren, JL; Watson, DE | 1 |
| Bobrowski, W; Brown, TP; Evering, W; Gukasyan, HJ; Hu, W; Huang, W; John-Baptiste, A; Thibault, S; Vitsky, A; Wang, J | 1 |
| Collett, MG; Matthews, ZM; Parton, KH | 1 |
25 other study(ies) available for alkenes and 1-cyano-2-hydroxy-3-butene
| Article | Year |
|---|---|
Separation of the toxic and glutathione-enhancing effects of the naturally occurring nitrile, cyanohydroxybutene.
Topics: Alkenes; Amylases; Animals; Glutathione; Lipase; Male; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344 | 1992 |
The acute pancreatotoxic effects of the plant nitrile 1-cyano-2-hydroxy-3-butene.
Topics: Acute Disease; Alkenes; Animals; Glutathione; Glutathione Transferase; Male; Nitriles; Pancreatic Diseases; Plant Extracts; Rats; Rats, Inbred Strains; Stereoisomerism | 1991 |
Enhancement of pancreatic and hepatic glutathione levels in rats during cyanohydroxybutene intoxication.
Topics: Alkenes; Animals; Glutathione; Liver; Male; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344 | 1990 |
Selective pancreato-toxicity in the rat induced by the naturally occurring plant nitrile 1-cyano-2-hydroxy-3-butene.
Topics: Alkenes; Amylases; Animals; Butanols; Glutathione; Male; Nitriles; Pancreas; Plant Extracts; Rats; Seeds; Sulfhydryl Compounds; Thiocyanates | 1988 |
The relationship of vehicle to target organ toxicology induced by the naturally occurring nitrile 1-cyano-2-hydroxy-3-butene.
Topics: Alkenes; Animals; Corn Oil; Glutathione; Kidney; Liver; Male; Nitriles; Pancreas; Pancreatic Diseases; Pharmaceutical Vehicles; Polysorbates; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiocyanates; Time Factors; Water | 1989 |
Differential effect of cyanohydroxybutene on glutathione synthesis in liver and pancreas of male rats.
Topics: Alkenes; Animals; Base Sequence; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Methionine Sulfoximine; Molecular Sequence Data; Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344; RNA, Messenger | 1993 |
Differential effects of cyanohydroxybutene and selenium on normal and neoplastic canine mammary cells in vitro.
Topics: Alkenes; Animals; Cell Survival; Dogs; Glutathione; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Nitriles; Selenium; Sodium Selenite; Tumor Cells, Cultured | 1993 |
In vitro metabolism of cyanohydroxybutene: formation of a glutathione-S-transferase catalyzed product.
Topics: Alcohol Dehydrogenase; Alkenes; Animals; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytosol; Dipeptides; Glutathione; Glutathione Transferase; Hydroxylation; Male; Microsomes, Liver; Nitriles; Oxidation-Reduction; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Tritium | 1993 |
Studies on the toxic effects of crambe meal and two of its constituents, 1-cyano-2-hydroxy-3-butene (CHB) and epi-progoitrin, in broiler chick diets.
Topics: Alkenes; Animals; Aspartate Aminotransferases; Chickens; Diet; Dietary Proteins; Eating; Female; Glucosinolates; Glycine max; Kidney; Liver; Male; Nitriles; Pancreas; Plant Proteins; Weight Gain; Zea mays | 1996 |
A comparison of the individual and collective effects of four glucosinolate breakdown products from brussels sprouts on induction of detoxification enzymes.
Topics: Alkenes; Animals; Brassica; Cytochrome P-450 CYP1A1; Enzyme Induction; Glucosinolates; Glutathione Reductase; Glutathione Transferase; Indoles; Isothiocyanates; Liver; Male; NAD(P)H Dehydrogenase (Quinone); Nitriles; Rats; Rats, Inbred F344 | 1998 |
Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis.
Topics: Acute Disease; Alkenes; Amylases; Animals; Apoptosis; Ceruletide; Disease Models, Animal; Female; Mice; Nitriles; Pancreas; Pancreatitis; Rats; Time Factors | 1998 |
Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts.
Topics: Alkenes; Animals; Anticarcinogenic Agents; Brassica; Enzyme Induction; Glucosinolates; Glutathione; Glutathione Transferase; Indoles; Isothiocyanates; Male; NAD(P)H Dehydrogenase (Quinone); Nitriles; Pancreas; Plant Extracts; Rats; Rats, Inbred F344 | 1998 |
The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables.
Topics: Alkenes; Animals; Antioxidants; Drug Interactions; Enzyme Induction; Glucosinolates; Glutathione Transferase; Inactivation, Metabolic; Indoles; Isoenzymes; Male; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Nitriles; Plant Extracts; Rats; RNA, Messenger; Up-Regulation; Vegetables | 2001 |
Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography.
Topics: Alkenes; Chemoprevention; Chromatography, High Pressure Liquid; Nitriles; Plant Extracts; Seeds; Vegetables | 2001 |
The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture.
Topics: Alkenes; Animals; Anticarcinogenic Agents; Cell Cycle; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Isothiocyanates; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Nitriles; Rats; Rats, Inbred F344; Sulfoxides; Thiocyanates | 2002 |
Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol.
Topics: Alkenes; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Enzymologic; Glucosinolates; Hydrolysis; Indoles; Mice; NAD(P)H Dehydrogenase (Quinone); Nitriles; Plant Extracts; Receptors, Aryl Hydrocarbon; Response Elements; RNA, Messenger; Transfection; Up-Regulation | 2004 |
Synergy among phytochemicals within crucifers: does it translate into chemoprotection?
Topics: Aflatoxin B1; Alkenes; Animals; Antioxidants; Brassicaceae; Diet; Dose-Response Relationship, Drug; Drug Synergism; Indoles; Liver; Male; Neoplasms, Experimental; Nitriles; Plant Preparations; Rats; Rats, Inbred F344 | 2005 |
Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway.
Topics: Alkenes; Animals; Apoptosis; Caspases; Cell Respiration; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Male; Membrane Potentials; Mice; Mitochondria; Nitriles; Pancreas; Signal Transduction | 2006 |
Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity.
Topics: Acute Disease; Alkenes; Amylases; Animals; Biomarkers; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Lipase; Male; Mice; Nitriles; Pancreas, Exocrine; Pancreatitis; Peptide Fragments; Predictive Value of Tests; Protein Array Analysis; Proteomics; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2007 |
Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene.
Topics: Acute Disease; Alkenes; Animals; Biomarkers; Cells, Cultured; Cluster Analysis; Disease Models, Animal; Male; Nitriles; Pancreas, Exocrine; Pancreatitis; Peptide Fragments; Peptide Hydrolases; Predictive Value of Tests; Protein Array Analysis; Proteomics; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sequence Analysis, Protein; Serum Albumin; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin | 2007 |
Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways.
Topics: Alkenes; Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cytokines; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Mice; Nitriles; Pancreatitis, Acute Necrotizing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.
Topics: Alkenes; Animals; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Male; Metabolomics; Molecular Structure; Nitriles; Organ Size; Pancreas, Exocrine; Pancreatitis; Rats; Rats, Sprague-Dawley; Reference Standards | 2009 |
Biomarkers of exocrine pancreatic injury in 2 rat acute pancreatitis models.
Topics: Acute Disease; Alkenes; Amylases; Animals; Biomarkers; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Exocrine Pancreatic Insufficiency; Lipase; Male; MicroRNAs; Nitriles; Pancreas; Rats; Rats, Sprague-Dawley | 2014 |
Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats.
Topics: Acute Disease; Alkenes; Animals; Biomarkers; Ceruletide; Exocrine Pancreatic Insufficiency; Humans; Male; Mice, Inbred C57BL; MicroRNAs; Nitriles; Organ Specificity; Pancreas, Exocrine; Rats, Sprague-Dawley; Rats, Wistar; Sensitivity and Specificity | 2017 |
Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits.
Topics: Alkenes; Animals; Biomarkers; Butanols; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glucosinolates; Liver; Male; Necrosis; Nitriles; Pilot Projects; Rabbits; Risk Assessment; Toxicity Tests | 2020 |