Page last updated: 2024-08-16

alkannin and shikonin

alkannin has been researched along with shikonin in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (13.33)18.2507
2000's14 (31.11)29.6817
2010's17 (37.78)24.3611
2020's8 (17.78)2.80

Authors

AuthorsStudies
Assimopoulou, AN; Couladouros, EA; Li, T; Mellidis, AS; Papageorgiou, VP; Pitsinos, EN; Plyta, ZF1
Cai, J; Ding, J; Duan, W; Liu, W; Lu, Q1
Lee, GH; Li, SY; Lin, CH; Shen, CC; Sun, CM; Syu, WJ1
Bai, LP; He, H; Jiang, ZH1
Li, S; Song, H; Wang, R; Zhang, X; Zhou, S1
Guan, X; Hou, X; Lan, L; Ni, T; Wang, M; Wen, Y; Yang, CG; Zhang, A; Zhang, N1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Valipour, M1
Ohno, A; Ozaki, Y; Saito, Y; Satake, M1
Ai, KH; Jin, J; Liu, H1
Abe, K; Ohno, A; Ozaki, Y; Saito, Y; Satake, M1
Ikeda, N; Kato, Y; Nakayama, M; Ozaki, Y; Sakaguchi, I; Satake, M; Suzuki, H; Tujimura, M1
Kohno, M; Maitani, Y; Masumizu, T; Nagai, T; Sekine, T; Takayama, K1
Assimopoulou, AN; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Papageorgiou, VP1
Andrikopoulos, NK; Assimopoulou, AN; Kaliora, AC; Papapeorgiou, VP1
Cheng, HW; Cheng, YW; Hu, CM; Kang, JJ1
Assimopoulou, AN; Papageorgiou, VP4
Assimopoulou, AN; Papageorgiou, VP; Spyros, A1
Assimopoulou, AN; Ganzera, M; Papageorgiou, VP; Stuppner, H1
Cristalli, G; Giardinà, D; Gioventù, G; Maggi, F; Ricciutelli, M; Sagratini, G; Vittori, S1
Assimopoulou, AN; Papageorgiou, VP; Stuppner, H; Sturm, S1
Assimopoulou, AN; Ballis, AC; Papageorgiou, VP1
Assimopoulou, AN; Noula, E; Papadoyannis, IN; Papageorgiou, VP; Samanidou, VF1
Jiang, Hda G; Li, SS; Peng, Y; Zhou, W1
Assimopoulou, AN; Kontogiannopoulos, KN; Panayiotou, C; Papageorgiou, VP; Tsivintzelis, I1
Anagnostou, TL; Giannakas, N; Kaldrymidou, E; Karayannopoulou, M; Loukopoulos, P; Papazoglou, LG; Savvas, I; Tsioli, V1
Chen, J; Hu, X; Jiang, Z; Wang, B; Wang, Y; Xie, J1
Akbari Noghabi, K; Haghbeen, K; Hosseini Shirazi, F; Mareftjo, MJ; Meshkat, A; Mousavi, A; Pourmolaei, S1
Ali, A; Assimopoulou, AN; Kolodziej, H; Papageorgiou, VP1
Assimopoulou, AN; Fessas, D; Ganzera, M; Papageorgiou, VP; Stuppner, H; Tappeiner, J; Vasiliou, A1
Cichosz, M; Pietrosiuk, A; Pilarek, M; Sykłowska-Baranek, K1
Cui, JH; Ding, J; Li, SS; Meng, QQ; Song, HL; Wang, RB; Xu, Y; Yang, K; Zhang, X; Zhou, W1
Chhaya, G; Nikita, G; Vivek, P1
Cui, JH; Li, SS; Meng, QQ; Xiao, S; Zhang, X; Zhou, W1
Durán, AG; Gutiérrez, MT; Macías, FA; Molinillo, JMG; Rial, C; Skoneczny, D; Torres, A; Valdivia, MM; Varela, RM; Weston, LA1
Cui, J; Dong, J; Huang, G; Li, S; Meng, Q; Sun, G; Zhang, Q; Zhang, X1
Li, S; Tang, CY; Wang, X; Wang, YT1
Tang, C1
Cañamares, MV; Leona, M; Mieites-Alonso, MG1
Ahmad, M; Assimopoulou, AN; Declerck, S; Koletti, AE; Molin, EM; Paun, O; Reichelt, M; Rödel, P; Rodić, N; Schneider, C; Varela Alonso, A1
Chen, Y; Deng, M; Fu, L; He, B; Liang, S; Lin, H; Lü, M; Qi, X; Zeng, S; Zhang, W; Zhao, W; Zhong, X1
Ahmad, Z; Harb, C; Lakhani, M; Saitis, T; Shareef, R; Watson, M1

Reviews

3 review(s) available for alkannin and shikonin

ArticleYear
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
    European journal of medicinal chemistry, 2022, May-05, Volume: 235

    Topics: Antineoplastic Agents; Apoptosis; Humans; Naphthoquinones; Neoplasms

2022
Alkannins and shikonins: a new class of wound healing agents.
    Current medicinal chemistry, 2008, Volume: 15, Issue:30

    Topics: Animals; Computer Simulation; Humans; Models, Chemical; Molecular Structure; Naphthoquinones; Stereoisomerism; Wound Healing

2008
Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives.
    Mini reviews in medicinal chemistry, 2018, Volume: 18, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Drug Screening Assays, Antitumor; Humans; Lithospermum; Naphthoquinones; Neoplasms; Reactive Oxygen Species

2018

Trials

1 trial(s) available for alkannin and shikonin

ArticleYear
Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2011, Volume: 75, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Drug Administration Schedule; Drug Combinations; Female; Forelimb; Isotonic Solutions; Laser-Doppler Flowmetry; Male; Naphthoquinones; Ringer's Lactate; Skin; Soft Tissue Injuries; Therapeutic Irrigation; Treatment Outcome; Wound Healing

2011

Other Studies

41 other study(ies) available for alkannin and shikonin

ArticleYear
Inhibition of topoisomerase I by naphthoquinone derivatives.
    Bioorganic & medicinal chemistry letters, 1998, Dec-01, Volume: 8, Issue:23

    Topics: Enzyme Inhibitors; Naphthoquinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Zinc

1998
Shikonin derivatives: synthesis and inhibition of human telomerase.
    Bioorganic & medicinal chemistry letters, 2002, May-20, Volume: 12, Issue:10

    Topics: Drug Design; Enzyme Inhibitors; Humans; Kinetics; Models, Molecular; Molecular Conformation; Naphthoquinones; Spectrophotometry; Structure-Activity Relationship; Telomerase

2002
Antimicrobial activities of naphthazarins from Arnebia euchroma.
    Journal of natural products, 2002, Volume: 65, Issue:12

    Topics: Anti-Bacterial Agents; Boraginaceae; Carcinoma, Hepatocellular; China; Drug Screening Assays, Antitumor; Electron Spin Resonance Spectroscopy; Enterococcus faecalis; Female; HeLa Cells; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Bark; Plants, Medicinal; Staphylococcus aureus; Stereoisomerism; Tumor Cells, Cultured; Vancomycin

2002
Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.
    Bioorganic & medicinal chemistry letters, 2012, Feb-15, Volume: 22, Issue:4

    Topics: Aminoglycosides; DNA; G-Quadruplexes; Glycosylation; Humans; Molecular Structure; Naphthoquinones; Spectrometry, Mass, Electrospray Ionization

2012
Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents.
    Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; K562 Cells; MCF-7 Cells; Molecular Structure; Naphthoquinones; Oximes; Structure-Activity Relationship

2014
Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A.
    Bioorganic & medicinal chemistry letters, 2018, 06-01, Volume: 28, Issue:10

    Topics: Aminoacyltransferases; Bacterial Proteins; Benzoquinones; Cell Wall; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fluorescence Resonance Energy Transfer; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Peptides; Protein Binding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staphylococcus aureus

2018
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:8

    Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gossypium; Granulation Tissue; Isomerism; Male; Naphthoquinones; Rats; Rats, Wistar

1994
[Studies on CD spectra of derivatives of shikonin and alkannin].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:4

    Topics: Circular Dichroism; Drugs, Chinese Herbal; Molecular Conformation; Naphthoquinones; Species Specificity; Stereoisomerism

1993
Comparative study on the accelerative effect of "koushikon" and "nanshikon" and their constituents on proliferation of granuloma tissue in rats.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:7

    Topics: Animals; Cell Division; Drugs, Chinese Herbal; Granuloma; Male; Naphthoquinones; Rats; Rats, Wistar; Stereoisomerism

1993
Study of the accelerating effect of shikonin and alkannin on the proliferation of granulation tissue in rats.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD3 Complex; Flow Cytometry; Gossypium; Granulation Tissue; Granuloma, Foreign-Body; Lymphocytes; Macrophage-1 Antigen; Male; Naphthoquinones; Rats; Rats, Wistar; Skin; Stimulation, Chemical

1998
[Effect of shikonin and alkannin on hydroxyl radical generation system concerned with iron ion].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1998, Volume: 118, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cyclic N-Oxides; Depression, Chemical; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxyl Radical; Iron; Isomerism; Naphthoquinones; Spin Trapping

1998
Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation.
    Archiv der Pharmazie, 2002, Volume: 335, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dimethyl Sulfoxide; Edema; Female; Free Radical Scavengers; Freund's Adjuvant; Lipid Peroxidation; Naphthoquinones; Rats; Rats, Inbred F344

2002
Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:5

    Topics: Cholesterol, LDL; Dose-Response Relationship, Drug; Gum Arabic; Humans; Karaya Gum; Mastic Resin; Naphthoquinones; Oils, Volatile; Oxidation-Reduction; Pigments, Biological; Pistacia; Plant Extracts; Resins, Plant; Structure-Activity Relationship; Triterpenes

2003
Impairment of vascular function of rat thoracic aorta in an endothelium-dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma.
    Planta medica, 2004, Volume: 70, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Boraginaceae; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; Inhibitory Concentration 50; Muscle Contraction; Naphthoquinones; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Wistar

2004
Encapsulation of isohexenylnaphthazarins in cyclodextrins.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:4

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cyclodextrins; Dosage Forms; Drug Carriers; Microscopy, Electron; Naphthoquinones; Plant Extracts; Solubility

2004
Study on isohexenylnaphthazarins polymerization in alkaline media.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:8

    Topics: Boraginaceae; Chromatography, Gel; Cosmetics; Drug Stability; Esters; Food Additives; Hydrogen-Ion Concentration; Hydrolysis; Naphthoquinones; Pharmaceutical Preparations; Plant Roots; Polymers

2004
Study on polymerization of the pharmaceutical substances isohexenylnaphthazarins.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:8

    Topics: Air; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Light; Models, Molecular; Molecular Structure; Naphthoquinones; Polymers; Solvents; Temperature

2004
Study on the enantiomeric ratio of the pharmaceutical substances alkannin and shikonin.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Naphthoquinones; Pharmaceutical Preparations; Stereoisomerism; Temperature

2004
Structure determination of oligomeric alkannin and shikonin derivatives.
    Biomedical chromatography : BMC, 2005, Volume: 19, Issue:7

    Topics: Boraginaceae; Chromatography, Gel; Dimerization; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Polymers

2005
Simultaneous determination of monomeric and oligomeric alkannins and shikonins by high-performance liquid chromatography-diode array detection-mass spectrometry.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:2

    Topics: Boraginaceae; Chromatography, High Pressure Liquid; Naphthoquinones; Plant Extracts; Plant Roots; Spectrometry, Mass, Electrospray Ionization

2008
Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification.
    Journal of separation science, 2008, Volume: 31, Issue:6-7

    Topics: Boraginaceae; Chromatography, High Pressure Liquid; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Solvents; Spectrometry, Mass, Electrospray Ionization

2008
Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:2

    Topics: Boraginaceae; Chromatography; Chromatography, High Pressure Liquid; Mass Spectrometry; Naphthoquinones; Plant Extracts; Plant Roots

2009
Solid-phase extraction for purification of alkannin/shikonin samples and isolation of monomeric and dimeric fractions.
    Analytical and bioanalytical chemistry, 2010, Volume: 397, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Dextrans; Naphthoquinones; Solid Phase Extraction

2010
Comparative study on enantiomeric excess of main akannin/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China.
    Biomedical chromatography : BMC, 2011, Volume: 25, Issue:10

    Topics: Boraginaceae; China; Chromatography, High Pressure Liquid; Circular Dichroism; Naphthoquinones; Plant Extracts; Plant Roots; Stereoisomerism

2011
Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications.
    International journal of pharmaceutics, 2011, May-16, Volume: 409, Issue:1-2

    Topics: Administration, Cutaneous; Bandages; Cellulose; Drug Combinations; Drugs, Chinese Herbal; Electrochemical Techniques; Excipients; Humans; Lactic Acid; Naphthoquinones; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Wound Healing

2011
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
    Oncogene, 2011, Oct-20, Volume: 30, Issue:42

    Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Glucose; Glycolysis; Humans; Lactic Acid; Naphthoquinones; Neoplasms; Pyruvate Kinase

2011
Detailed investigations on the solid cell culture and antimicrobial activities of the Iranian Arnebia euchroma.
    Journal of biomedicine & biotechnology, 2011, Volume: 2011

    Topics: Anti-Bacterial Agents; Bacteria; Boraginaceae; Fungi; Naphthoquinones; Plant Extracts; Plant Roots; Seeds; Tissue Culture Techniques

2011
Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.
    Planta medica, 2011, Volume: 77, Issue:18

    Topics: Amphotericin B; Animals; Antiprotozoal Agents; Bignoniaceae; Boraginaceae; Culture Media; Drosera; Flow Cytometry; Glutathione; Green Fluorescent Proteins; Hydroxylation; Inhibitory Concentration 50; Leishmania; Macrophages; Mammals; Naphthoquinones; Organisms, Genetically Modified; Parasitic Sensitivity Tests; Structure-Activity Relationship

2011
Quantitative determination of alkannins and shikonins in endemic Mediterranean Alkanna species.
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:7

    Topics: Boraginaceae; Chromatography, High Pressure Liquid; Naphthoquinones; Plant Extracts; Plant Roots

2014
Liquid perfluorodecalin application for in situ extraction and enhanced naphthoquinones production in Arnebia euchroma cell suspension cultures.
    Applied biochemistry and biotechnology, 2014, Volume: 172, Issue:5

    Topics: Biomass; Boraginaceae; Chromatography, High Pressure Liquid; Culture Media; Drugs, Chinese Herbal; Ethylenes; Fluorocarbons; Naphthoquinones; Plant Growth Regulators; Plant Somatic Embryogenesis Techniques

2014
Design, synthesis, and biological evaluation of shikonin and alkannin derivatives as potential anticancer agents via a prodrug approach.
    ChemMedChem, 2014, Volume: 9, Issue:12

    Topics: Alkylation; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Female; Male; Mice; Microsomes, Liver; Naphthoquinones; Neoplasms; Prodrugs; Rats; Reactive Oxygen Species; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Transplantation, Homologous

2014
Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides.
    Natural product research, 2015, Volume: 29, Issue:16

    Topics: Animals; Boraginaceae; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Rats; Wound Healing

2015
Bioactivity and quantitative analysis of isohexenylnaphthazarins in root periderm of two Echium spp.: E. plantagineum and E. gaditanum.
    Phytochemistry, 2017, Volume: 141

    Topics: Australia; Cell Line, Tumor; Cell Survival; Echium; Humans; Naphthoquinones; Plant Extracts; Plant Roots; Spain; Triticum

2017
DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme.
    Molecular pharmaceutics, 2019, 01-07, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1B1; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; K562 Cells; Mice; Naphthoquinones; Prodrugs; Xenograft Model Antitumor Assays

2019
Comparative genome/transcriptome analysis probes Boraginales' phylogenetic position, WGDs in Boraginales, and key enzyme genes in the alkannin/shikonin core pathway.
    Molecular ecology resources, 2020, Volume: 20, Issue:1

    Topics: Biosynthetic Pathways; Gene Duplication; Gene Expression Profiling; Genome, Plant; Magnoliopsida; Naphthoquinones; Phylogeny; Plant Proteins; Transcriptome

2020
Exploring the evolutionary process of alkannin/shikonin O-acyltransferases by a reliable Lithospermum erythrorhizon genome.
    DNA research : an international journal for rapid publication of reports on genes and genomes, 2021, Sep-13, Volume: 28, Issue:5

    Topics: Acyltransferases; Lithospermum; Naphthoquinones

2021
Raman, SERS and DFT analysis of the natural red dyes of Japanese origin alkannin and shikonin.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2022, Jan-15, Volume: 265

    Topics: Coloring Agents; Japan; Naphthoquinones; Spectrum Analysis, Raman

2022
Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale.
    Scientific reports, 2022, 10-12, Volume: 12, Issue:1

    Topics: Acetates; Cyclopentanes; Lithospermum; Mevalonic Acid; Naphthoquinones; Oxylipins; Pharmaceutical Preparations; Plant Growth Regulators; Salicylic Acid

2022
A comparative investigation of catalytic mechanism and domain between catechol-O-methyltransferase isoforms by isomeric shikonin and alkannin.
    International journal of biological macromolecules, 2023, Jul-01, Volume: 242, Issue:Pt 1

    Topics: Animals; Catechol O-Methyltransferase; Humans; Molecular Docking Simulation; Protein Isoforms; Rats

2023
Shikonin and Alkannin inhibit ATP synthase and impede the cell growth in Escherichia coli.
    International journal of biological macromolecules, 2023, Dec-31, Volume: 253, Issue:Pt 4

    Topics: Adenosine Triphosphate; Escherichia coli; Naphthoquinones; Phytochemicals

2023