alkannin has been researched along with naphthoquinones in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.88) | 18.7374 |
| 1990's | 5 (7.35) | 18.2507 |
| 2000's | 17 (25.00) | 29.6817 |
| 2010's | 30 (44.12) | 24.3611 |
| 2020's | 12 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Papageorgiou, VP | 1 |
| Cong, PZ | 1 |
| Hoshi, A; Iitaka, Y; Kataoka, Y; Kuretani, K; Otsuka, H; Sankawa, U | 1 |
| Ohno, A; Ozaki, Y; Saito, Y; Satake, M | 1 |
| Ai, KH; Jin, J; Liu, H | 1 |
| Abe, K; Ohno, A; Ozaki, Y; Saito, Y; Satake, M | 1 |
| Ikeda, N; Kato, Y; Nakayama, M; Ozaki, Y; Sakaguchi, I; Satake, M; Suzuki, H; Tujimura, M | 1 |
| Kohno, M; Maitani, Y; Masumizu, T; Nagai, T; Sekine, T; Takayama, K | 1 |
| Assimopoulou, AN; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Papageorgiou, VP | 1 |
| Lee, GH; Li, SY; Lin, CH; Shen, CC; Sun, CM; Syu, WJ | 1 |
| Andrikopoulos, NK; Assimopoulou, AN; Kaliora, AC; Papapeorgiou, VP | 1 |
| Cheng, HW; Cheng, YW; Hu, CM; Kang, JJ | 1 |
| Assimopoulou, AN; Papageorgiou, VP | 5 |
| Chan, AS; Duan, ZF; Feng, GK; Gu, LQ; Huang, ZS; Li, YM; Liu, ZC; Wu, HQ; Xie, BF | 1 |
| Assimopoulou, AN; Papageorgiou, VP; Spyros, A | 1 |
| Bu, XZ; Chan, AS; Gu, LQ; Huang, ZS; Liu, ZC; Shen, YD; Wu, HQ; Xie, BF; Zhang, ZL | 1 |
| Assimopoulou, AN; Karapanagiotis, I; Kokkini, S; Papageorgiou, VP; Vasiliou, A | 1 |
| Assimopoulou, AN; Ganzera, M; Papageorgiou, VP; Stuppner, H | 1 |
| Cristalli, G; Giardinà, D; Gioventù, G; Maggi, F; Ricciutelli, M; Sagratini, G; Vittori, S | 1 |
| Assimopoulou, AN; Papageorgiou, VP; Stuppner, H; Sturm, S | 1 |
| Assimopoulou, AN; Ballis, AC; Papageorgiou, VP | 1 |
| Akgun, IH; Bedir, E; Deliloglu-Gurhan, I; Korkmaz, KS; Sevimli-Gur, C | 1 |
| Assimopoulou, AN; Noula, E; Papadoyannis, IN; Papageorgiou, VP; Samanidou, VF | 1 |
| Jiang, Hda G; Li, SS; Peng, Y; Zhou, W | 1 |
| Assimopoulou, AN; Kontogiannopoulos, KN; Panayiotou, C; Papageorgiou, VP; Tsivintzelis, I | 1 |
| Anagnostou, TL; Giannakas, N; Kaldrymidou, E; Karayannopoulou, M; Loukopoulos, P; Papazoglou, LG; Savvas, I; Tsioli, V | 1 |
| Chen, J; Hu, X; Jiang, Z; Wang, B; Wang, Y; Xie, J | 1 |
| Bedir, E; Bogurcu, N; Korkmaz, KS; Ozmen, B; Sevimli-Gur, C | 1 |
| Akbari Noghabi, K; Haghbeen, K; Hosseini Shirazi, F; Mareftjo, MJ; Meshkat, A; Mousavi, A; Pourmolaei, S | 1 |
| Ali, A; Assimopoulou, AN; Kolodziej, H; Papageorgiou, VP | 1 |
| Bai, LP; He, H; Jiang, ZH | 1 |
| Du, GJ; Huu Tung, N; Shoyama, Y; Wang, CZ; Yuan, CS | 1 |
| Furusawa, Y; Hassan, MA; Kondo, T; Shimizu, T; Tabuchi, Y; Yoshihisa, Y | 1 |
| Du, GJ; Shoyama, Y; Tung, NH; Wang, CZ; Yuan, CS | 1 |
| Assimopoulou, AN; Fessas, D; Ganzera, M; Papageorgiou, VP; Stuppner, H; Tappeiner, J; Vasiliou, A | 1 |
| Cichosz, M; Pietrosiuk, A; Pilarek, M; Sykłowska-Baranek, K | 1 |
| HATOS, G; ROM, P | 1 |
| Li, S; Song, H; Wang, R; Zhang, X; Zhou, S | 1 |
| Cui, JH; Ding, J; Li, SS; Meng, QQ; Song, HL; Wang, RB; Xu, Y; Yang, K; Zhang, X; Zhou, W | 1 |
| Chhaya, G; Nikita, G; Vivek, P | 1 |
| Maheshwari, DK; Shukla, S; Singh, LK | 1 |
| Babu, UV; Dilmel, K; Mohapatra, S; Nishant, M; Patki, PS; Sandeep Varma, R; Sharath Kumar, LM; Thiyagarajan, OS; Vijaykumar, M | 1 |
| Di, T; Li, P; Lin, Y; Liu, X; Wang, Y; Zeng, Z; Zhang, L; Zhao, J | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Ohta, Y; Ozaki, K; Shindo, S | 1 |
| Cui, JH; Li, SS; Meng, QQ; Xiao, S; Zhang, X; Zhou, W | 1 |
| Durán, AG; Gutiérrez, MT; Macías, FA; Molinillo, JMG; Rial, C; Skoneczny, D; Torres, A; Valdivia, MM; Varela, RM; Weston, LA | 1 |
| Cao, Y; Deng, X; Fan, R; Fan, Z; Li, L; Li, Y; Lian, J; Lu, J; Ma, B; Song, X; Sun, D; Xue, W; Zhai, Y; Zhang, C; Zhang, T; Zhao, J; Zhu, Z | 1 |
| Chen, Y; Li, H | 1 |
| Demirezer, LO; Guvenalp, Z; Kazaz, C; Kuruuzum-Uz, A; Salih, B; Saracoglu, I; Yuzbasioglu Baran, M | 1 |
| Cui, J; Dong, J; Huang, G; Li, S; Meng, Q; Sun, G; Zhang, Q; Zhang, X | 1 |
| Guan, L; Liu, M; Sun, B; Zhang, J | 1 |
| Hou, Q; Li, B; Li, Y; Lin, Q; Yin, C; Zhang, L | 1 |
| Ma, J; Mo, F; Su, J; Yang, X; Zhang, J; Zhang, P | 1 |
| Li, S; Tang, CY; Wang, X; Wang, YT | 1 |
| Zhai, N; Zhang, G; Zhang, X | 1 |
| Gong, D; Guo, Y; Li, K; Li, Q; Lin, P; Liu, X; Yuan, H; Zhang, J; Zhao, G; Zheng, Q | 1 |
| Liu, T; Song, W; Zhuang, Y | 1 |
| Fan, W; Huang, R; Liu, G; Yang, X | 1 |
| Tang, C | 1 |
| Cañamares, MV; Leona, M; Mieites-Alonso, MG | 1 |
| Valipour, M | 1 |
| Ahmad, M; Assimopoulou, AN; Declerck, S; Koletti, AE; Molin, EM; Paun, O; Reichelt, M; Rödel, P; Rodić, N; Schneider, C; Varela Alonso, A | 1 |
| Dai, ZQ; Gao, F; Gao, S; Gu, YH; Guo, ZQ; Lei, HM; Lu, MJ; Luo, YJ; Shang, BX; Xu, B; Zeng, Q; Zhang, T; Zhang, ZJ | 1 |
| Ahmad, Z; Harb, C; Lakhani, M; Saitis, T; Shareef, R; Watson, M | 1 |
3 review(s) available for alkannin and naphthoquinones
| Article | Year |
|---|---|
Alkannins and shikonins: a new class of wound healing agents.
Topics: Animals; Computer Simulation; Humans; Models, Chemical; Molecular Structure; Naphthoquinones; Stereoisomerism; Wound Healing | 2008 |
Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Drug Screening Assays, Antitumor; Humans; Lithospermum; Naphthoquinones; Neoplasms; Reactive Oxygen Species | 2018 |
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Topics: Antineoplastic Agents; Apoptosis; Humans; Naphthoquinones; Neoplasms | 2022 |
1 trial(s) available for alkannin and naphthoquinones
| Article | Year |
|---|---|
Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Drug Administration Schedule; Drug Combinations; Female; Forelimb; Isotonic Solutions; Laser-Doppler Flowmetry; Male; Naphthoquinones; Ringer's Lactate; Skin; Soft Tissue Injuries; Therapeutic Irrigation; Treatment Outcome; Wound Healing | 2011 |
64 other study(ies) available for alkannin and naphthoquinones
| Article | Year |
|---|---|
Wound healing properties of naphthaquinone pigments from Alkanna tinctoria.
Topics: Anti-Bacterial Agents; Humans; Naphthoquinones; Plant Extracts; Plants, Medicinal; Salmonella; Varicose Ulcer; Wound Healing | 1978 |
[Mass spectrometric studies on alkannins].
Topics: China; Mass Spectrometry; Naphthoquinones; Plants, Medicinal | 1984 |
Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin derivatives.
Topics: Animals; Antineoplastic Agents, Phytogenic; Mice; Naphthols; Naphthoquinones; Stereoisomerism; X-Ray Diffraction | 1981 |
Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gossypium; Granulation Tissue; Isomerism; Male; Naphthoquinones; Rats; Rats, Wistar | 1994 |
[Studies on CD spectra of derivatives of shikonin and alkannin].
Topics: Circular Dichroism; Drugs, Chinese Herbal; Molecular Conformation; Naphthoquinones; Species Specificity; Stereoisomerism | 1993 |
Comparative study on the accelerative effect of "koushikon" and "nanshikon" and their constituents on proliferation of granuloma tissue in rats.
Topics: Animals; Cell Division; Drugs, Chinese Herbal; Granuloma; Male; Naphthoquinones; Rats; Rats, Wistar; Stereoisomerism | 1993 |
Study of the accelerating effect of shikonin and alkannin on the proliferation of granulation tissue in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD3 Complex; Flow Cytometry; Gossypium; Granulation Tissue; Granuloma, Foreign-Body; Lymphocytes; Macrophage-1 Antigen; Male; Naphthoquinones; Rats; Rats, Wistar; Skin; Stimulation, Chemical | 1998 |
[Effect of shikonin and alkannin on hydroxyl radical generation system concerned with iron ion].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cyclic N-Oxides; Depression, Chemical; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxyl Radical; Iron; Isomerism; Naphthoquinones; Spin Trapping | 1998 |
Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dimethyl Sulfoxide; Edema; Female; Free Radical Scavengers; Freund's Adjuvant; Lipid Peroxidation; Naphthoquinones; Rats; Rats, Inbred F344 | 2002 |
Antimicrobial activities of naphthazarins from Arnebia euchroma.
Topics: Anti-Bacterial Agents; Boraginaceae; Carcinoma, Hepatocellular; China; Drug Screening Assays, Antitumor; Electron Spin Resonance Spectroscopy; Enterococcus faecalis; Female; HeLa Cells; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Bark; Plants, Medicinal; Staphylococcus aureus; Stereoisomerism; Tumor Cells, Cultured; Vancomycin | 2002 |
Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.
Topics: Cholesterol, LDL; Dose-Response Relationship, Drug; Gum Arabic; Humans; Karaya Gum; Mastic Resin; Naphthoquinones; Oils, Volatile; Oxidation-Reduction; Pigments, Biological; Pistacia; Plant Extracts; Resins, Plant; Structure-Activity Relationship; Triterpenes | 2003 |
Impairment of vascular function of rat thoracic aorta in an endothelium-dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Boraginaceae; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; Inhibitory Concentration 50; Muscle Contraction; Naphthoquinones; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Wistar | 2004 |
Encapsulation of isohexenylnaphthazarins in cyclodextrins.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cyclodextrins; Dosage Forms; Drug Carriers; Microscopy, Electron; Naphthoquinones; Plant Extracts; Solubility | 2004 |
Preparation and release studies of alkannin-containing microcapsules.
Topics: Capsules; Cellulose; Drug Compounding; Drug Stability; Microscopy, Electron, Scanning; Naphthoquinones; Particle Size; Pistacia; Polymers; Resins, Plant; Sodium Dodecyl Sulfate; Surface Properties; Surface-Active Agents; Waxes | 2004 |
Synthesis and cytotoxicity study of alkannin derivatives.
Topics: Boraginaceae; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Naphthoquinones; Structure-Activity Relationship | 2004 |
Study on isohexenylnaphthazarins polymerization in alkaline media.
Topics: Boraginaceae; Chromatography, Gel; Cosmetics; Drug Stability; Esters; Food Additives; Hydrogen-Ion Concentration; Hydrolysis; Naphthoquinones; Pharmaceutical Preparations; Plant Roots; Polymers | 2004 |
Study on polymerization of the pharmaceutical substances isohexenylnaphthazarins.
Topics: Air; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Light; Models, Molecular; Molecular Structure; Naphthoquinones; Polymers; Solvents; Temperature | 2004 |
Study on the enantiomeric ratio of the pharmaceutical substances alkannin and shikonin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Naphthoquinones; Pharmaceutical Preparations; Stereoisomerism; Temperature | 2004 |
Structure determination of oligomeric alkannin and shikonin derivatives.
Topics: Boraginaceae; Chromatography, Gel; Dimerization; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Polymers | 2005 |
The molecular mechanisms involved in the cytotoxicity of alkannin derivatives.
Topics: Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Oxygen; Structure-Activity Relationship | 2005 |
Analysis of alkannin derivatives from Alkanna species by high-performance liquid chromatography/photodiode array/mass spectrometry.
Topics: Boraginaceae; Chromatography, High Pressure Liquid; Geography; Greece; Naphthoquinones; Plant Extracts; Plant Roots; Spectrometry, Mass, Electrospray Ionization | 2006 |
Simultaneous determination of monomeric and oligomeric alkannins and shikonins by high-performance liquid chromatography-diode array detection-mass spectrometry.
Topics: Boraginaceae; Chromatography, High Pressure Liquid; Naphthoquinones; Plant Extracts; Plant Roots; Spectrometry, Mass, Electrospray Ionization | 2008 |
Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification.
Topics: Boraginaceae; Chromatography, High Pressure Liquid; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Solvents; Spectrometry, Mass, Electrospray Ionization | 2008 |
Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography.
Topics: Boraginaceae; Chromatography; Chromatography, High Pressure Liquid; Mass Spectrometry; Naphthoquinones; Plant Extracts; Plant Roots | 2009 |
Cytotoxic naphthoquinones from Alkanna cappadocica ( perpendicular).
Topics: Animals; Antineoplastic Agents, Phytogenic; Boraginaceae; Chlorocebus aethiops; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Naphthoquinones; Plants, Medicinal; Turkey; Vero Cells | 2010 |
Solid-phase extraction for purification of alkannin/shikonin samples and isolation of monomeric and dimeric fractions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Dextrans; Naphthoquinones; Solid Phase Extraction | 2010 |
Comparative study on enantiomeric excess of main akannin/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China.
Topics: Boraginaceae; China; Chromatography, High Pressure Liquid; Circular Dichroism; Naphthoquinones; Plant Extracts; Plant Roots; Stereoisomerism | 2011 |
Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications.
Topics: Administration, Cutaneous; Bandages; Cellulose; Drug Combinations; Drugs, Chinese Herbal; Electrochemical Techniques; Excipients; Humans; Lactic Acid; Naphthoquinones; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Wound Healing | 2011 |
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Glucose; Glycolysis; Humans; Lactic Acid; Naphthoquinones; Neoplasms; Pyruvate Kinase | 2011 |
ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Boraginaceae; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type I; Histones; Humans; Mitochondria; Naphthoquinones; Reactive Oxygen Species; Topoisomerase I Inhibitors | 2011 |
Detailed investigations on the solid cell culture and antimicrobial activities of the Iranian Arnebia euchroma.
Topics: Anti-Bacterial Agents; Bacteria; Boraginaceae; Fungi; Naphthoquinones; Plant Extracts; Plant Roots; Seeds; Tissue Culture Techniques | 2011 |
Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Bignoniaceae; Boraginaceae; Culture Media; Drosera; Flow Cytometry; Glutathione; Green Fluorescent Proteins; Hydroxylation; Inhibitory Concentration 50; Leishmania; Macrophages; Mammals; Naphthoquinones; Organisms, Genetically Modified; Parasitic Sensitivity Tests; Structure-Activity Relationship | 2011 |
Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.
Topics: Aminoglycosides; DNA; G-Quadruplexes; Glycosylation; Humans; Molecular Structure; Naphthoquinones; Spectrometry, Mass, Electrospray Ionization | 2012 |
Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Boraginaceae; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; HCT116 Cells; Humans; Naphthoquinones; Plant Extracts; Plant Roots; Rats | 2013 |
Alkannin, HSP70 inducer, protects against UVB-induced apoptosis in human keratinocytes.
Topics: Analysis of Variance; Apoptosis; Benzhydryl Compounds; Blotting, Western; Caspase 3; Cell Line; DNA Fragmentation; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Keratinocytes; Naphthoquinones; Oligonucleotide Array Sequence Analysis; Pyrrolidinones; Real-Time Polymerase Chain Reaction; Ultraviolet Rays | 2012 |
Isolation and chemopreventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Boraginaceae; Caspases; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Naphthoquinones; Plant Roots; Structure-Activity Relationship | 2013 |
Quantitative determination of alkannins and shikonins in endemic Mediterranean Alkanna species.
Topics: Boraginaceae; Chromatography, High Pressure Liquid; Naphthoquinones; Plant Extracts; Plant Roots | 2014 |
Liquid perfluorodecalin application for in situ extraction and enhanced naphthoquinones production in Arnebia euchroma cell suspension cultures.
Topics: Biomass; Boraginaceae; Chromatography, High Pressure Liquid; Culture Media; Drugs, Chinese Herbal; Ethylenes; Fluorocarbons; Naphthoquinones; Plant Growth Regulators; Plant Somatic Embryogenesis Techniques | 2014 |
[Alkannin as a substitute for litmus].
Topics: Humans; Indicators and Reagents; Naphthoquinones | 1951 |
Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; K562 Cells; MCF-7 Cells; Molecular Structure; Naphthoquinones; Oximes; Structure-Activity Relationship | 2014 |
Design, synthesis, and biological evaluation of shikonin and alkannin derivatives as potential anticancer agents via a prodrug approach.
Topics: Alkylation; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Female; Male; Mice; Microsomes, Liver; Naphthoquinones; Neoplasms; Prodrugs; Rats; Reactive Oxygen Species; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Transplantation, Homologous | 2014 |
Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides.
Topics: Animals; Boraginaceae; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Rats; Wound Healing | 2015 |
Antibacterial effect of butyryl alkannin from Arnebia euchroma against vancomycin-resistant pathogens of Enterococcus faecalis causing urinary tract infections.
Topics: Anti-Bacterial Agents; Boraginaceae; Enterococcus faecalis; Microbial Sensitivity Tests; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Urinary Tract Infections; Vancomycin Resistance | 2015 |
Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f.
Topics: Animals; Boraginaceae; Cellular Senescence; Collagen Type I; Cosmetics; Elastin; Fibroblasts; Hemolysis; Humans; Hydrogen Peroxide; Keratinocytes; Mice; Naphthoquinones; NIH 3T3 Cells; Plant Roots; Protein Precursors; Skin Aging; Up-Regulation | 2016 |
Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model.
Topics: Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Inflammation Mediators; Lymphocyte Activation; Lymphocytes; Male; Mice, Inbred BALB C; Naphthoquinones; Psoriasis; Severity of Illness Index; Skin; Time Factors | 2015 |
Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells.
Topics: Cells, Cultured; Chemokine CCL3; Chemokine CCL5; Humans; I-kappa B Proteins; Interleukin-1beta; Ligands; Naphthoquinones; Periodontal Ligament; Phosphorylation; Proteolysis; Transcription Factor RelA | 2016 |
Bioactivity and quantitative analysis of isohexenylnaphthazarins in root periderm of two Echium spp.: E. plantagineum and E. gaditanum.
Topics: Australia; Cell Line, Tumor; Cell Survival; Echium; Humans; Naphthoquinones; Plant Extracts; Plant Roots; Spain; Triticum | 2017 |
Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cytokines; Diabetes Complications; Diabetes Mellitus; Hep G2 Cells; Humans; Inflammation; Liver; Liver Diseases; Mice, Inbred C57BL; Naphthoquinones; rho-Associated Kinases; Signal Transduction | 2018 |
RETRACTED: Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210.
Topics: Apoptosis; Cell Line; Cell Survival; Cytokines; Epithelial Cells; Humans; Inflammation; Kidney Tubules, Proximal; Lipopolysaccharides; MicroRNAs; Naphthoquinones; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protective Agents; Signal Transduction; Up-Regulation | 2018 |
Cytotoxic naphthoquinones from
Topics: Antineoplastic Agents; Apoptosis; Boraginaceae; Caspase 3; Cell Line; DNA Fragmentation; Humans; Inhibitory Concentration 50; Naphthoquinones; Plant Extracts | 2020 |
DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1B1; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; K562 Cells; Mice; Naphthoquinones; Prodrugs; Xenograft Model Antitumor Assays | 2019 |
RETRACTED: Alkannin inhibits proliferation, migration and invasion of hepatocellular carcinoma cells via regulation of miR-92a.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Naphthoquinones; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction | 2019 |
Alkannin attenuates lipopolysaccharide-induced lung injury in mice via Rho/ROCK/NF-κB pathway.
Topics: A549 Cells; Acute Lung Injury; Animals; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Naphthoquinones; NF-kappa B; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2019 |
Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Candida albicans; Candidiasis, Vulvovaginal; Disease Models, Animal; Drug Carriers; Female; Hydrogels; Naphthoquinones; Radiotherapy; Rats; Treatment Outcome; Uterine Cervical Neoplasms | 2019 |
Comparative genome/transcriptome analysis probes Boraginales' phylogenetic position, WGDs in Boraginales, and key enzyme genes in the alkannin/shikonin core pathway.
Topics: Biosynthetic Pathways; Gene Duplication; Gene Expression Profiling; Genome, Plant; Magnoliopsida; Naphthoquinones; Phylogeny; Plant Proteins; Transcriptome | 2020 |
Alkannin represses growth of pancreatic cancer cells based on the down regulation of miR-199a.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; Klotho Proteins; MAP Kinase Signaling System; MicroRNAs; Naphthoquinones; Pancreatic Neoplasms; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway.
Topics: Animals; Apoptosis; Autophagy; Boraginaceae; Cell Survival; Dose-Response Relationship, Drug; Female; HCT116 Cells; HEK293 Cells; Hep G2 Cells; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Naphthoquinones; Plant Extracts; Reactive Oxygen Species | 2020 |
CYP82AR Subfamily Proteins Catalyze C-1' Hydroxylations of Deoxyshikonin in the Biosynthesis of Shikonin and Alkannin.
Topics: Boraginaceae; Catalysis; Cytochrome P-450 Enzyme System; Hydroxylation; Molecular Structure; Naphthoquinones; Plant Extracts; Terpenes | 2021 |
β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling.
Topics: Animals; Boraginaceae; Disease Models, Animal; Female; Naphthoquinones; Pressure; Rabbits; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Varicose Ulcer; Wound Healing | 2021 |
Exploring the evolutionary process of alkannin/shikonin O-acyltransferases by a reliable Lithospermum erythrorhizon genome.
Topics: Acyltransferases; Lithospermum; Naphthoquinones | 2021 |
Raman, SERS and DFT analysis of the natural red dyes of Japanese origin alkannin and shikonin.
Topics: Coloring Agents; Japan; Naphthoquinones; Spectrum Analysis, Raman | 2022 |
Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale.
Topics: Acetates; Cyclopentanes; Lithospermum; Mevalonic Acid; Naphthoquinones; Oxylipins; Pharmaceutical Preparations; Plant Growth Regulators; Salicylic Acid | 2022 |
Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Mice; Naphthoquinones; Pyruvate Kinase | 2023 |
Shikonin and Alkannin inhibit ATP synthase and impede the cell growth in Escherichia coli.
Topics: Adenosine Triphosphate; Escherichia coli; Naphthoquinones; Phytochemicals | 2023 |