alexidine and biguanides

alexidine has been researched along with biguanides in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (27.27)	18.7374
1990's	1 (1.82)	18.2507
2000's	7 (12.73)	29.6817
2010's	25 (45.45)	24.3611
2020's	7 (12.73)	2.80

Authors

Authors	Studies
Finn, SB; Jamison, HC; Weatherford, TW	1
Alms, TH; Carlson, HC; Porter, K	1
Chawner, JA; Gilbert, P	2
Shern, RJ	1
Addy, M; Moran, J	2
Balanyk, TE; Sandham, HJ	1
Rapani, E	1
Addy, M; Roberts, WR	4
Horikoshi, AK; Kwok, YY; Newman, MG; Tsao, TF	1
La Porta, E; Papeschi, G; Pinzauti, S	1
Beggs, TS; Day, MJ; Hudson, RA; Maillard, JY; Russell, AD	1
Jessiman, W	1
Oduyebo, OO; Ogunsola, FT; Orji, BO	1
Gilbert, P; Moore, LE	1
Au, PY; Bastianutto, C; Hedley, DW; Ito, E; Liu, FF; Mao, X; Mocanu, JD; Schimmer, A; Yip, KW	1
Cavanagh, HD; Imayasu, M; Ohashi, Y; Shimada, S; Shiraishi, A	1
Jerala, R; Zorko, M	1
Alizadeh, H; Cavanagh, HD; Neelam, S	1
Casey, PJ; Dixon, JE; Doughty-Shenton, D; Joseph, JD; Kim, Y; Lu, D; Pagliarini, DJ; Zhang, J	1
Mori, O; Nishida, T; Toyohara, M; Ueda, K; Yanai, R	1
Bae, KS; Baek, SH; Chang, SW; Cho, K; Gu, Y; Hong, ST; Jung, IY; Kim, HS; Kim, JW; Kum, KY; Lee, W; Lee, Y; Son, WJ; Zhu, Q	1
Allen, C; Chan, CY; Charkhzarrin, S; De Haro, LP; Lee, SA; Melman, SD; Parra, KJ; Prudom, C; Raines, SM; Sklar, LA	1
Bullock, JD; Elder, BL; Khalaf, SZ; Khamis, HJ; Warwar, RE	1
Baek, SH; Han, SH; Kim, HS; Kum, KY; Lee, Y; Woo Chang, S; Zhu, Q	1
Arias-Moliz, MT; Baca, P; Ferrer-Luque, CM; Rodríguez-Archilla, A; Silveira, LF	1
Arias-Moliz, MT; Baca, P; Barrios, R; Bravo, M; Ferrer-Luque, CM; Ruiz-Linares, M	1
Berg, T; Gräber, M; Gröst, C; Hell, M	1
Lazon de la Jara, P; Naduvilath, T; Tilia, D; Weng, R; Willcox, MD	1
Bullock, JD; Elder, BL; Sizemore, IE; Snyder, SA; Warwar, RE	1
Aguado, B; Arias-Moliz, T; Baca, P; de Castro, P; Ferrer-Luque, CM; Ruiz-Linares, M	1
Bunting, KD; Cooper, TM; Liu, X; Qu, CK; Yu, WM; Zheng, H	1
Bettis, S; Boxer, MB; Chiang, CY; Curtis, M; Ferrer, M; Jadhav, A; Kenny, HA; Lal-Nag, M; Lengyel, E; Li, Z; Mitra, AK; Schryver, EM; Shen, M; White, EA; Zhang, Y	1
Bergmanson, JP; Burns, AR; Kolar, SS; Manarang, JC; McDermott, AM; Miller, WL	1
Bullock, JD; Elder, BL; Khamis, HJ; Warwar, RE	1
Cheng, TS; Dong, Y; Gao, J; Ng, PY; Pavlos, NJ; Qin, A; Steer, JH; Zheng, MH; Zhu, X	1
Aguado-Pérez, B; Arias-Moliz, MT; Baca, P; Ferrer-Luque, CM; Ruiz-Linares, M	1
Berntsen, DA; Hickson-Curran, SB; Jones, LW; Maldonado-Codina, C; Mathew, JH; Morgan, PB; Nichols, JJ; Schulze, MM	1
Balto, H; Bukhary, S	1
Brekken, RA; Douglas, PM; Gao, J; Huang, G; Jaramillo, J; Li, Y; Lin, R; Lin, Z; Luo, M; MacMillan, JB; McMillan, EA; Mendiratta, S; Niederstrasser, H; Oswald, NW; Posner, BA; Wang, C; Wang, Z; White, MA; Zhao, T; Zhou, A	1
Bang, AG; Feltes, M; Kaufman, RJ; Ory, DS; Pugach, EK	1
Gupta, S; Jagtap, P; Kashyap, HK; Khanna, S; Kumari, P; Mishra, R; Mittal, B	1
Alqarihi, A; Ibrahim, AS; Mamouei, Z; Mansour, MK; Singh, S; Uppuluri, P; Xu, S	1
David, FDC; Edmunds, CE; Phillips, KS; Samant, VN; Thompson, BL; Wei, X; Wheeler, JF; Wheeler, JM; Wheeler, SK	1
Kitamura, Y; Mizuno, Y; Willcox, M; Yamasaki, K	1
Aydemir, E; Bayrak, OF; Kasikci, E; Sahin, F; Yogurtcu, BM	1
Kumar Vijay, A; Willcox, M; Yasir, M	1
Chen, BB; Houston, R; Larsen, MB; Mullett, SJ; Murakami, K; Narendra, DP; Sekine, S; Sekine, Y; Wendell, SG	1
Bridts, CH; Ebo, DG; Elst, J; Garvey, LH; Hagendorens, MM; Mertens, C; Moonen, N; Sabato, V; van der Poorten, MM; Van Gasse, AL	1
Bai, J; Cao, Y; Cui, L; Jia, X; Liu, F; Luo, E; Zhang, Y	1
Date, A; Ibrahim, AS; Nabeela, S; Uppuluri, P	1

Reviews

1 review(s) available for alexidine and biguanides

Article	Year
Cationic antiseptics: diversity of action under a common epithet. Journal of applied microbiology, 2005, Volume: 99, Issue:4 Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacteria; Biguanides; Cations; Cell Membrane; Chlorhexidine; Drug Resistance, Bacterial; Models, Biological; Models, Chemical; Quaternary Ammonium Compounds	2005

Trials

5 trial(s) available for alexidine and biguanides

Article	Year
Effects of an alexidine mouthwash on dental plaque and gingivitis in humans over a six-month period. Journal of the American Dental Association (1939), 1977, Volume: 94, Issue:3 Topics: Adolescent; Adult; Aged; Biguanides; Dental Plaque; Drug Evaluation; Female; Gingivitis; Humans; Male; Middle Aged; Mouthwashes; Placebos; Tooth Discoloration	1977
Comparison of the bisbiguanide antiseptics alexidine and chlorhexidine. I. Effect on plaque accumulation and salivary bacteria. Journal of clinical periodontology, 1981, Volume: 8, Issue:3 Topics: Adult; Bacteria; Biguanides; Chlorhexidine; Dental Plaque; Humans; Male; Mouthwashes; Saliva; Time Factors	1981
Comparison of the bisbiguanide antiseptics alexidine and chlorhexidine. II. Clinical and in vitro staining properties. Journal of clinical periodontology, 1981, Volume: 8, Issue:3 Topics: Biguanides; Chlorhexidine; Color; Humans; In Vitro Techniques; Mouthwashes; Random Allocation; Tea; Tongue; Tooth Discoloration	1981
Short-term clinical comparison of two dual-disinfection multipurpose disinfecting solutions. Eye & contact lens, 2014, Volume: 40, Issue:1 Topics: Adolescent; Adult; Biguanides; Contact Lens Solutions; Contact Lenses, Hydrophilic; Corneal Diseases; Cross-Over Studies; Female; Humans; Hydrogels; Linear Models; Male; Middle Aged; Propylamines; Prospective Studies; Wettability; Young Adult	2014
Subjective Comfort and Physiology with Modern Contact Lens Care Products. Optometry and vision science : official publication of the American Academy of Optometry, 2016, Volume: 93, Issue:8 Topics: Adolescent; Adult; Aged; Biguanides; Contact Lens Solutions; Contact Lenses, Hydrophilic; Female; Humans; Male; Middle Aged; Ocular Physiological Phenomena; Patient Comfort; Polymers; Propylamines; Staining and Labeling; Surveys and Questionnaires	2016

Other Studies

49 other study(ies) available for alexidine and biguanides

Article	Year
The effect of an alexidine mouthwash on dental plaque and gingivitis. Journal of periodontology, 1977, Volume: 48, Issue:4 Topics: Adolescent; Adult; Aged; Biguanides; Color; Dental Plaque; Gingivitis; Humans; Middle Aged; Mouthwashes; Placebos; Tongue Diseases; Tooth Discoloration	1977
A comparative study of the bactericidal and growth inhibitory activities of the bisbiguanides alexidine and chlorhexidine. The Journal of applied bacteriology, 1989, Volume: 66, Issue:3 Topics: Adsorption; Biguanides; Cell Membrane; Chlorhexidine; Escherichia coli; Molecular Structure; Oxidation-Reduction	1989
Interaction of the bisbiguanides chlorhexidine and alexidine with phospholipid vesicles: evidence for separate modes of action. The Journal of applied bacteriology, 1989, Volume: 66, Issue:3 Topics: Anti-Bacterial Agents; Biguanides; Cell Membrane Permeability; Chlorhexidine; Drug Resistance, Microbial; Escherichia coli; Phospholipids; Proteus; Providencia; Spheroplasts	1989
Effects of various organic compounds and fluoride on dental plaque and caries in rats. Caries research, 1988, Volume: 22, Issue:3 Topics: Actinomyces; Animals; Biguanides; Cariostatic Agents; Cations; Dental Caries; Dental Plaque; Female; Fluorides; Lysine; Mouthwashes; Rats; Rats, Inbred Strains; Streptococcus mutans; Thiophenes	1988
The pattern of adsorption of cationic antiseptics to polymethylmethacrylate. Journal of oral rehabilitation, 1985, Volume: 12, Issue:1 Topics: Adsorption; Anti-Infective Agents, Local; Biguanides; Cetylpyridinium; Chlorhexidine; Humans; Hydrogen-Ion Concentration; Methylmethacrylates; Saliva; Spectrophotometry; Surface Properties	1985
Development of sustained-release antimicrobial dental varnishes effective against Streptococcus mutans in vitro. Journal of dental research, 1985, Volume: 64, Issue:12 Topics: Amines; Amino Alcohols; Biguanides; Chlorhexidine; Delayed-Action Preparations; Erythromycin; Fluorides; Kinetics; Microbial Sensitivity Tests; Paint; Pharmaceutical Vehicles; Plant Extracts; Streptococcus mutans; Styrax	1985
[Mouthrinses in the prevention of dental caries]. Rivista di odontostomatologia e implantoprotesi, 1985, Issue:2 Topics: Biguanides; Chlorhexidine; Dental Caries; Dental Plaque; Humans; Mouthwashes	1985
The effect of surface adsorption and staining reactions on the antimicrobial properties of some cationic antiseptic mouthwashes. Journal of periodontology, 1984, Volume: 55, Issue:5 Topics: Adsorption; Anti-Infective Agents, Local; Bacteria; Biguanides; Cetylpyridinium; Chlorhexidine; Dental Plaque; Escherichia coli; Hexetidine; Humans; Methylmethacrylates; Mouthwashes; Staphylococcus; Tooth Discoloration	1984
The use of polymethylmethacrylate to compare the adsorption and staining reactions of some cationic antiseptics. Journal of periodontology, 1981, Volume: 52, Issue:7 Topics: Adsorption; Anti-Infective Agents, Local; Biguanides; Cetylpyridinium; Chemical Phenomena; Chemistry, Physical; Chlorhexidine; Color; Methylmethacrylates; Pyridinium Compounds; Saliva; Tea	1981
Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. Journal of clinical periodontology, 1981, Volume: 8, Issue:4 Topics: Bacteria; Biguanides; Cetylpyridinium; Chlorhexidine; Culture Media; Hexetidine; Humans; In Vitro Techniques; Mouthwashes; Pyridinium Compounds; Saliva; Time Factors	1981
Effect of Chinese and western antimicrobial agents on selected oral bacteria. Journal of dental research, 1982, Volume: 61, Issue:9 Topics: Bacteria; Biguanides; Flavonoids; Humans; Microbial Sensitivity Tests; Periodontal Diseases; Plant Extracts; Tetracycline; Tin Fluorides	1982
Potentiometric analysis of chlorhexidine and alexidine salts in pharmaceutical preparations. Pharmaceutica acta Helvetiae, 1981, Volume: 56, Issue:12 Topics: Biguanides; Chlorhexidine; Dosage Forms; Potentiometry	1981
The use of an automated assay to assess phage survival after a biocidal treatment. The Journal of applied bacteriology, 1996, Volume: 80, Issue:6 Topics: 1-Propanol; Biguanides; Cetylpyridinium; Chlorhexidine; Coliphages; Disinfectants; Escherichia coli; Ethanol; Glutaral; Peracetic Acid; Phenol; Phenols; Spectrophotometry	1996
Lotions and lubricants. The practising midwife, 2001, Volume: 4, Issue:3 Topics: Biguanides; Evidence-Based Medicine; Female; Humans; Lubrication; Maternal-Child Nursing; Midwifery; Nurse Midwives; Nursing Evaluation Research; Physical Examination; Practice Guidelines as Topic; Surveys and Questionnaires; United Kingdom; Vagina; Vaginal Creams, Foams, and Jellies	2001
Contamination levels of in-use disinfectants in a teaching hospital in Lagos, Nigeria. African journal of medicine and medical sciences, 2002, Volume: 31, Issue:2 Topics: Bacillus; Biguanides; Cetrimonium Compounds; Chlorhexidine; Colony Count, Microbial; Disinfectants; Drug Combinations; Drug Contamination; Drug Storage; Enterobacter; Escherichia coli; Hospitals, Teaching; Humans; Hydrogen Peroxide; Klebsiella; Microbial Sensitivity Tests; Nigeria; Proteus mirabilis; Pseudomonas; Risk Factors; Sodium Hypochlorite; Staphylococcus; Time Factors; Water Microbiology	2002
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular cancer therapeutics, 2006, Volume: 5, Issue:9 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biguanides; Carcinoma, Squamous Cell; Caspase 2; Caspase 9; Cisplatin; Enzyme Activation; Female; Fluorouracil; Humans; Hypopharyngeal Neoplasms; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, SCID; Mitochondrial Membranes; NIH 3T3 Cells; Xenograft Model Antitumor Assays	2006
Effects of multipurpose solutions on corneal epithelial tight junctions. Eye & contact lens, 2008, Volume: 34, Issue:1 Topics: Biguanides; Cell Membrane Permeability; Cells, Cultured; Disinfectants; Epithelium, Corneal; Humans; Intercellular Junctions; Membrane Potentials; Microscopy, Confocal; Microscopy, Electron, Transmission	2008
Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. The Journal of antimicrobial chemotherapy, 2008, Volume: 62, Issue:4 Topics: Animals; Anti-Bacterial Agents; Biguanides; Cell Line; Chlorhexidine; Genes, Reporter; Humans; Immunosuppressive Agents; Lipopolysaccharides; Luciferases; Macrophage Activation; Mice; NF-kappa B; Nitric Oxide; Teichoic Acids	2008
Amoebicidal activities of alexidine against 3 pathogenic strains of acanthamoeba. Eye & contact lens, 2009, Volume: 35, Issue:1 Topics: Acanthamoeba; Administration, Topical; Amebiasis; Amebicides; Animals; Biguanides; Chlorhexidine; Cornea; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Epithelium, Corneal; Parasitic Sensitivity Tests; Trophozoites	2009
Pharmacological targeting of the mitochondrial phosphatase PTPMT1. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2 Topics: Animals; Biguanides; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Mitochondria; Mitochondrial Proteins; Phosphorylation; Rats; Rats, Wistar	2010
Effects of tonicity-adjusting and surfactant agents on the antimicrobial activity of alexidine. Eye & contact lens, 2011, Volume: 37, Issue:2 Topics: Anti-Infective Agents; Bacteria; Biguanides; Cell Membrane; Dose-Response Relationship, Drug; Drug Combinations; Fungi; Poloxamer; Propylene Glycol; Sodium Chloride; Surface-Active Agents	2011
Chemical interaction of alexidine and sodium hypochlorite. Journal of endodontics, 2012, Volume: 38, Issue:1 Topics: Aniline Compounds; Bicuspid; Biguanides; Chemical Precipitation; Chlorhexidine; Color; Dental Disinfectants; Dental Pulp Cavity; Dentin; Humans; Materials Testing; Microscopy, Electron, Scanning; Root Canal Irrigants; Sodium Hypochlorite; Spectrometry, Mass, Electrospray Ionization	2012
Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). The Journal of biological chemistry, 2012, Mar-23, Volume: 287, Issue:13 Topics: Biguanides; Candida albicans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen-Ion Concentration; Intracellular Membranes; Mutation; Protein Structure, Tertiary; Proton-Motive Force; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vacuolar Proton-Translocating ATPases; Vacuoles	2012
Pan-antimicrobial failure of alexidine as a contact lens disinfectant when heated in Bausch & Lomb plastic containers: implications for the worldwide Fusarium keratitis epidemic of 2004 to 2006. Eye & contact lens, 2012, Volume: 38, Issue:4 Topics: Biguanides; Contact Lens Solutions; Contact Lenses; Disinfection; Drug Packaging; Drug Storage; Eye Infections, Fungal; Fusarium; Glass; Hot Temperature; Humans; Keratitis; Plastics	2012
Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection. International journal of oral science, 2013, Volume: 5, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Bacterial Load; Biguanides; Cattle; Cell Membrane; Chlorhexidine; Dentin; Enterococcus faecalis; Microscopy, Electron, Scanning; Random Allocation; Time Factors	2013
Antimicrobial activity of alexidine alone and associated with N-acetylcysteine against Enterococcus faecalis biofilm. International journal of oral science, 2013, Volume: 5, Issue:3 Topics: Acetylcysteine; Anti-Infective Agents, Local; Biguanides; Biofilms; Dental Pulp Cavity; Drug Combinations; Enterococcus faecalis; Humans	2013
Antimicrobial substantivity of alexidine and chlorhexidine in dentin. Journal of endodontics, 2013, Volume: 39, Issue:11 Topics: Anti-Infective Agents, Local; Bacterial Load; Bacteriological Techniques; Biguanides; Chlorhexidine; Dentin; Enterococcus faecalis; Humans; Materials Testing; Microbial Viability; Root Canal Irrigants; Time Factors	2013
Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Biguanides; Disinfectants; Drug Design; Humans; Molecular Docking Simulation; Protein Interaction Maps; Stereoisomerism	2013
Mechanism of drug failure in fusarium keratitis, 2004-2006. The New England journal of medicine, 2014, Jan-02, Volume: 370, Issue:1 Topics: Biguanides; Chromatography, Liquid; Contact Lens Solutions; Eye Infections, Fungal; Fusariosis; Fusarium; Hot Temperature; Humans; Keratitis; Plastics; Tandem Mass Spectrometry	2014
Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm. Annals of clinical microbiology and antimicrobials, 2014, Aug-20, Volume: 13 Topics: Anti-Bacterial Agents; Biguanides; Biofilms; Cetrimonium; Cetrimonium Compounds; Chlorhexidine; Dentin; Dose-Response Relationship, Drug; Humans; Microbial Viability; Streptococcus mutans; Time Factors	2014
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood, 2015, Mar-05, Volume: 125, Issue:10 Topics: Aerobiosis; AMP-Activated Protein Kinases; Animals; Biguanides; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Enzyme Activation; Enzyme Inhibitors; Glycolysis; Hematopoietic Stem Cells; Hypoglycemic Agents; Metformin; Mice; Oxygen Consumption; PTEN Phosphohydrolase	2015
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nature communications, 2015, Feb-05, Volume: 6 Topics: Animals; Antineoplastic Agents; Benzophenanthridines; Biguanides; Cantharidin; Cell Adhesion; Cell Movement; Cell Proliferation; Coculture Techniques; Epithelial Cells; Escin; Extracellular Matrix; Female; Fibroblasts; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Nude; Ovarian Neoplasms; Primary Cell Culture; Prochlorperazine; Tomatine; Tumor Microenvironment; Xenograft Model Antitumor Assays	2015
Contact lens care solution killing efficacy against Acanthamoeba castellanii by in vitro testing and live-imaging. Contact lens & anterior eye : the journal of the British Contact Lens Association, 2015, Volume: 38, Issue:6 Topics: Acanthamoeba castellanii; Acanthamoeba Keratitis; Amebiasis; Amebicides; Animals; Biguanides; Contact Lens Solutions; Disinfection; Drug Combinations; Hydrogen Peroxide; Parasitic Sensitivity Tests; Polymers; Propylamines; Reference Standards; Trophozoites	2015
Microbiological Investigations of ReNu Plastic Bottles and the 2004 to 2006 ReNu With MoistureLoc-Related Worldwide Fusarium Keratitis Event. Eye & contact lens, 2016, Volume: 42, Issue:3 Topics: Anti-Bacterial Agents; Biguanides; Contact Lens Solutions; Contact Lenses; Drug Packaging; Drug Storage; Fusarium; Glass; Hot Temperature; Plastics; Polymers	2016
Alexidine Dihydrochloride Attenuates Osteoclast Formation and Bone Resorption and Protects Against LPS-Induced Osteolysis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, Volume: 31, Issue:3 Topics: Animals; Apoptosis; Biguanides; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Nucleus; Enzyme Activation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Osteoclasts; Osteolysis; RANK Ligand; RAW 264.7 Cells; Skull	2016
Efficacy of antimicrobial solutions against polymicrobial root canal biofilm. International endodontic journal, 2017, Volume: 50, Issue:1 Topics: Anti-Bacterial Agents; Biguanides; Biofilms; Cetrimonium; Cetrimonium Compounds; Chlorhexidine; Dentin; Humans; Root Canal Therapy; Sodium Hypochlorite	2017
Antibacterial Efficacy of Octenisept, Alexidine, Chlorhexidine, and Sodium Hypochlorite against Enterococcus faecalis Biofilms. Journal of endodontics, 2017, Volume: 43, Issue:4 Topics: Anti-Bacterial Agents; Biguanides; Biofilms; Chlorhexidine; Dentin; Enterococcus faecalis; Humans; Imines; Microscopy, Confocal; Pyridines; Sodium Hypochlorite	2017
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature communications, 2017, 12-22, Volume: 8, Issue:1 Topics: Animals; Autophagosomes; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biguanides; Caenorhabditis elegans; Calcium; Caloric Restriction; Diet, High-Fat; Digoxin; Enzyme Inhibitors; Fatty Liver; HeLa Cells; High-Throughput Screening Assays; Humans; Lactams; Lipid Metabolism; Liver; Longevity; Lysosomes; Metabolic Syndrome; Mice; Mitochondria; Starvation	2017
High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Human molecular genetics, 2018, 06-15, Volume: 27, Issue:12 Topics: Biguanides; Carrier Proteins; Cholesterol; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Fibroblasts; Filipin; Histone Deacetylase Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lysosomal-Associated Membrane Protein 1; Lysosomes; Membrane Glycoproteins; Metabolome; Mutation, Missense; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C	2018
Mechanistic Evaluation of Lipopolysaccharide-Alexidine Interaction Using Spectroscopic and in Silico Approaches. ACS infectious diseases, 2018, 11-09, Volume: 4, Issue:11 Topics: Anti-Bacterial Agents; Biguanides; Binding Sites; Fluorescence; Gram-Negative Bacteria; Guanidine; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Static Electricity; Surface Plasmon Resonance	2018
Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere, 2018, 10-31, Volume: 3, Issue:5 Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Biguanides; Biofilms; Candida; Candida albicans; Central Venous Catheters; Drug Evaluation, Preclinical; Drug Synergism; Fluconazole; Mice; Microbial Viability; Models, Animal; Small Molecule Libraries	2018
Analysis of polyhexamethylene biguanide and alexidine in contact lens solutions using capillary electrophoresis, ultra-performance liquid chromatography and quadrupole time of flight mass spectrometry. Talanta, 2019, Dec-01, Volume: 205 Topics: Biguanides; Chromatography, Liquid; Chromatography, Reverse-Phase; Contact Lens Solutions; Disinfectants; Electrophoresis, Capillary; Mass Spectrometry; Reproducibility of Results; Solid Phase Extraction	2019
The Antimicrobial Activity of Multipurpose Disinfecting Solutions in the Presence of Different Organic Soils. Eye & contact lens, 2020, Volume: 46, Issue:4 Topics: Bacteria; Biguanides; Colony Count, Microbial; Contact Lens Solutions; Disinfection; Fungi; Hydrogen Peroxide; Microbial Sensitivity Tests; Polymers; Povidone-Iodine; Tears	2020
Repurposing of Alexidine Dihydrochloride as an Apoptosis Initiator and Cell Cycle Inhibitor in Human Pancreatic Cancer. Anti-cancer agents in medicinal chemistry, 2020, Volume: 20, Issue:16 Topics: Antineoplastic Agents; Apoptosis; Biguanides; Cell Cycle; Cell Line; Dose-Response Relationship, Drug; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pancreatic Neoplasms; Structure-Activity Relationship	2020
Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus. Contact lens & anterior eye : the journal of the British Contact Lens Association, 2022, Volume: 45, Issue:5 Topics: Animals; Antiviral Agents; Biguanides; Contact Lens Solutions; Contact Lenses; COVID-19; Disinfectants; Humans; Hydrogen Peroxide; Mice; Phosphates; Povidone-Iodine; SARS-CoV-2	2022
Discovery of bactericides as an acute mitochondrial membrane damage inducer. Molecular biology of the cell, 2021, 11-01, Volume: 32, Issue:21 Topics: Anti-Bacterial Agents; Biguanides; Chlorhexidine; Drug Evaluation, Preclinical; HeLa Cells; Homeostasis; Humans; Membranes; Metalloendopeptidases; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Phospholipids	2021
Mast cell activation test: A new asset in the investigation of the chlorhexidine cross-sensitization profile. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2022, Volume: 52, Issue:11 Topics: Biguanides; Cell Degranulation; Chlorhexidine; Humans; Hypersensitivity; Immunoglobulin E; Mast Cells; Nerve Tissue Proteins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide	2022
Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei. International journal for parasitology. Drugs and drug resistance, 2022, Volume: 19 Topics: Animals; Antimalarials; Biguanides; Culicidae; Enzyme Inhibitors; Humans; Malaria; Male; Parasites; Phosphoric Monoester Hydrolases; Plasmodium berghei; Sexual Development	2022
Antifungal activity of alexidine dihydrochloride in a novel diabetic mouse model of dermatophytosis. Frontiers in cellular and infection microbiology, 2022, Volume: 12 Topics: Animals; Antifungal Agents; Biguanides; Diabetes Mellitus, Experimental; Disease Models, Animal; Mice; Terbinafine; Tinea	2022