alendronate and ym 529

alendronate has been researched along with ym 529 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (36.84)29.6817
2010's11 (57.89)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Martin, MB; Oldfield, E; Szabo, CM1
Burzynska, A; Chan, JM; Colantino, A; Ghosh, S; Kafarski, P; Meints, G; Morita, CT; Oldfield, E; Raker, AM; Sanders, JM; Song, Y; Wang, H1
Araujo, FG; Chan, JM; Ling, Y; Moreno, SN; Odeh, S; Oldfield, E; Sahota, G1
Axelson, J; Cao, R; Chang, SC; Chang, TH; Guo, RT; Hudock, MP; K-M Chen, C; Ko, TP; Kumar, A; Liang, PH; No, JH; Oldfield, E; Song, Y; Wang, AH; Zhang, Y1
Fukunaga, M1
Matsumoto, T1
Hagino, H; Itabashi, A; Matsumoto, T; Minamide, T; Mizunuma, H; Morii, H; Nakamura, T; Nishizawa, Y; Ohashi, Y; Shiraki, M; Sone, T; Taketani, Y1
Amagase, K; Inaba, A; Ishikawa, Y; Murakami, T; Nukui, K; Senta, T; Takeuchi, K1
Okamoto, K; Okimoto, N; Sakai, A; Yoshioka, T1
Imano, M; Itoh, T; Komai, M; Mukai, J; Nishida, S; Ogawa, N; Satou, T; Tsubaki, M1
Iwata, K; Mashiba, T; Nozaki, K; Tanaka, M; Yamagami, Y; Yamamoto, T1
Fujiwara, D; Imano, M; Itoh, T; Komai, M; Mashimo, K; Mukai, J; Nishida, S; Ogawa, N; Sakaguchi, K; Sakamoto, K; Satou, T; Shimaoka, H; Takeda, T; Tsubaki, M1
Igase, M; Kohara, K; Miki, T; Ochi, M; Ohara, M; Okada, Y; Tabara, Y; Takita, R1
Furuya, T; Hasegawa, M; Hirabayashi, H; Iwamoto, J; Kumakubo, T; Makita, K; Okano, H; Urano, T1
Ishimoto, T; Matsugaki, A; Nakano, T; Tanaka, M1
Ebina, K; Hashimoto, J; Hirao, M; Kaneshiro, S; Noguchi, T; Yoshikawa, H; Yukioka, M1
Hyodo, K; Kamada, H; Mishima, H; Nishino, T; Nozawa, D; Yamazaki, M1
Iwata, K; Mashiba, T; Saito, M; Tanaka, M; Yamagami, Y; Yamamoto, T1
Chen, D; Huang, X; Jin, Z; Liu, Q; Ma, T; Ye, Z1

Reviews

2 review(s) available for alendronate and ym 529

ArticleYear
[New development in bisphosphonate treatment. Review of effect on bone metabolism by minodronic acid in primary osteoporosis].
    Clinical calcium, 2009, Volume: 19, Issue:1

    Topics: Alendronate; Amino Acids; Biomarkers; Bone and Bones; Bone Density Conservation Agents; Clinical Trials, Phase III as Topic; Collagen Type I; Diphosphonates; Fractures, Spontaneous; Humans; Imidazoles; Osteoporosis; Peptides

2009
Minodronate in the treatment of osteoporosis: A systematic review and meta-analysis.
    Medicine, 2020, Oct-02, Volume: 99, Issue:40

    Topics: Aged; Aged, 80 and over; Alendronate; Alkaline Phosphatase; Bone Density Conservation Agents; Case-Control Studies; Collagen Type I; Creatinine; Diphosphonates; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Middle Aged; Osteoporosis; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risedronic Acid; Spinal Fractures; Tartrate-Resistant Acid Phosphatase; Treatment Outcome; Vitamin D

2020

Trials

4 trial(s) available for alendronate and ym 529

ArticleYear
A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis.
    Bone, 2009, Volume: 44, Issue:6

    Topics: Aged; Alendronate; Bone Density; Bone Density Conservation Agents; Diphosphonates; Double-Blind Method; Female; Humans; Imidazoles; Middle Aged; Osteoporosis, Postmenopausal; Treatment Outcome

2009
A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients.
    Journal of bone and mineral metabolism, 2013, Volume: 31, Issue:2

    Topics: Aged; Alendronate; Back Pain; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Bone Resorption; Collagen Type I; Diphosphonates; Drug Administration Schedule; Female; Gastrointestinal Tract; Humans; Imidazoles; Osteoporosis, Postmenopausal; Pain Measurement; Peptides; Surveys and Questionnaires

2013
Change in arterial stiffness associated with monthly bisphosphonate treatment in women with postmenopausal osteoporosis.
    Menopause (New York, N.Y.), 2014, Volume: 21, Issue:9

    Topics: Administration, Oral; Aged; Alendronate; Ankle Brachial Index; Atherosclerosis; Bone Density Conservation Agents; Brachial Artery; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Osteoporosis, Postmenopausal; Prospective Studies; Pulsatile Flow; Treatment Outcome

2014
Patient preference for monthly bisphosphonate versus weekly bisphosphonate in a cluster-randomized, open-label, crossover trial: Minodroate Alendronate/Risedronate Trial in Osteoporosis (MARTO).
    Journal of bone and mineral metabolism, 2016, Volume: 34, Issue:2

    Topics: Aged; Aged, 80 and over; Alendronate; Cross-Over Studies; Demography; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Male; Middle Aged; Osteoporosis; Patient Preference; Risedronic Acid

2016

Other Studies

13 other study(ies) available for alendronate and ym 529

ArticleYear
An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs.
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Alkyl and Aryl Transferases; Animals; Bone Resorption; Crystallography, X-Ray; Dictyostelium; Diphosphonates; Enzyme Inhibitors; Geranyltranstransferase; Humans; Inhibitory Concentration 50; Models, Molecular; Quantitative Structure-Activity Relationship; Rats

2002
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
    Journal of medicinal chemistry, 2004, Jan-15, Volume: 47, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Diphosphonates; Geranyltranstransferase; Humans; Leishmania major; Lymphocyte Activation; Models, Molecular; Quantitative Structure-Activity Relationship; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Tumor Necrosis Factor-alpha

2004
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: Aldose-Ketose Isomerases; Alkyl and Aryl Transferases; Animals; Antiprotozoal Agents; Cell Line; Diphosphonates; Fosfomycin; Geranyltranstransferase; Humans; Mice; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Quantitative Structure-Activity Relationship; Toxoplasma; Toxoplasmosis

2005
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Antineoplastic Agents; Crystallography, X-Ray; Diphosphonates; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesyltranstransferase; Humans; K562 Cells; Magnetic Resonance Spectroscopy; Models, Molecular; Quantitative Structure-Activity Relationship

2008
[New bisphosphonates and trends in drug therapy for osteoporosis: preface].
    Clinical calcium, 2009, Volume: 19, Issue:1

    Topics: Alendronate; Bone Density Conservation Agents; Clinical Trials as Topic; Diphosphonates; Etidronic Acid; Evidence-Based Medicine; Humans; Imidazoles; Osteoporosis; Risedronic Acid; Zoledronic Acid

2009
Gastric ulcerogenic and healing impairment effects of risedronate, a nitrogen-containing bisphosphonate in rats. Comparison with alendronate and minodronate.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2011, Volume: 62, Issue:6

    Topics: Alendronate; Animals; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Imidazoles; Male; Nitrogen; Rats; Rats, Sprague-Dawley; Risedronic Acid; Stomach Ulcer; Wound Healing

2011
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
    Biochemical pharmacology, 2013, Jan-15, Volume: 85, Issue:2

    Topics: Alendronate; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Bone Density Conservation Agents; Cell Line, Tumor; Cell Nucleus; Cell Survival; Diphosphonates; Gene Expression Regulation, Neoplastic; Gene Silencing; Hematologic Neoplasms; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Prenylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; TOR Serine-Threonine Kinases

2013
Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys.
    Bone, 2013, Volume: 54, Issue:1

    Topics: Alendronate; Animals; Biomechanical Phenomena; Bone and Bones; Bone Density Conservation Agents; Bone Remodeling; Calcification, Physiologic; Diphosphonates; Female; Femur; Imidazoles; Lumbar Vertebrae; Macaca fascicularis; Ovariectomy

2013
Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation.
    Journal of biomedical science, 2014, Feb-03, Volume: 21

    Topics: Alendronate; Animals; Apoptosis; Bone Diseases, Metabolic; Diphosphonates; Humans; Imidazoles; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Signaling System; Mice; Nitrogen; Oncogene Protein v-akt; Osteoclasts; Polyisoprenyl Phosphates; RANK Ligand

2014
Evaluation of crystallographic orientation of biological apatite in vertebral cortical bone in ovariectomized cynomolgus monkeys treated with minodronic acid and alendronate.
    Journal of bone and mineral metabolism, 2016, Volume: 34, Issue:2

    Topics: Alendronate; Animals; Apatites; Area Under Curve; Biomarkers; Bone Density; Bone Remodeling; Cortical Bone; Crystallography; Diphosphonates; Female; Imidazoles; Lumbar Vertebrae; Macaca fascicularis; Osteocalcin; Ovariectomy; Tibia; X-Ray Diffraction

2016
Effects of switching weekly alendronate or risedronate to monthly minodronate in patients with rheumatoid arthritis: a 12-month prospective study.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016, Volume: 27, Issue:1

    Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Alendronate; Arthritis, Rheumatoid; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Diphosphonates; Drug Administration Schedule; Drug Substitution; Female; Humans; Imidazoles; Middle Aged; Osteoporosis, Postmenopausal; Osteoporotic Fractures; Patient Preference; Prospective Studies; Risedronic Acid

2016
Location of fractures and the characteristics of patients with atypical femoral fractures: analyses of 38 Japanese cases.
    Journal of bone and mineral metabolism, 2017, Volume: 35, Issue:2

    Topics: Aged; Aged, 80 and over; Alendronate; Asian People; Bone Density Conservation Agents; Bone Remodeling; Diphosphonates; Female; Femoral Fractures; Femur; Glucocorticoids; Humans; Imidazoles; Japan; Male; Middle Aged; Proton Pump Inhibitors; Retrospective Studies; Risedronic Acid

2017
Effects of suppressed bone remodeling by minodronic acid and alendronate on bone mass, microdamage accumulation, collagen crosslinks and bone mechanical properties in the lumbar vertebra of ovariectomized cynomolgus monkeys.
    Bone, 2017, Volume: 97

    Topics: Alendronate; Animals; Biomechanical Phenomena; Bone Density; Bone Remodeling; Collagen; Cross-Linking Reagents; Diphosphonates; Female; Imidazoles; Lumbar Vertebrae; Macaca fascicularis; Organ Size; Ovariectomy; Stress, Mechanical

2017