alendronate and odanacatib

alendronate has been researched along with odanacatib in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Black, WC; Cusick, TE; Duong, LT; Gauthier, JY; Gentile, MA; Kimmel, DB; Masarachia, PJ; Pennypacker, BL; Samadfam, R; Scott, BB; Smith, SY1
Cabal, A; Cook, L; Dardzinski, BJ; Duong, LT; Evelhoch, JL; Hangartner, TN; Hargreaves, R; Jayakar, RY; Mathers, PD; McCracken, PJ; Motzel, S; Phillips, EA; Posavec, DJ; Sardesai, S; Savitz, AT; Scott, BB; Szumiloski, J; Williams, DS; Winkelmann, CT1
Brown, K; Cabal, A; Cook, L; Dardzinski, BJ; Duong, LT; Evelhoch, JL; Hangartner, TN; Hargreaves, R; Jayakar, RY; Krause, S; Mathers, PD; McCracken, PJ; Motzel, SL; Pickarski, M; Purcell, M; Savitz, AT; Scott, BB; Somayajula, S; Szumiloski, J; Williams, DS; Winkelmann, CT1
Bonnick, S; Chapurlat, R; DaSilva, C; De Villiers, T; Gurner, D; Le Bailly De Tilleghem, C; Leung, AT; Odio, A; Palacios, S; Scott, BB1
Andersen, TL; Delaissé, JM; Duong, LT; Jensen, PR; Pennypacker, BL1
Kim, H; Kim, M; Ko, H; Yang, W1
Ikeda, K; Matsuoka, K; Rahman, MM; Takeshita, S1
Duong, le T; Gatto, NT; Gilberto, D; Kimmel, DB; Pennypacker, BL; Samadfam, R; Smith, SY1
Bellare, JR; Bora, HK; Chattopadhyay, N; Khan, MP; Nagar, GK; Parameswaran, V; Sanyal, S; Shrivastava, P; Singh, AK; Tiwari, MC1
Duong, le T; Hu, G; Loboda, A; Muise, ES; Pickarski, M; Podtelezhnikov, AA; Tan, Y; Thomspon, JR1
Chen, CM; Cusick, T; Duong, LT; Pennypacker, BL; Pickarski, M; Samadfam, R; Scott, K; Smith, SY; Zhuo, Y1
Consolaro, A; Cunha, NBFF; da Silva, LAB; da Silva, RAB; de Queiroz, AM; Leoni, GB; Nelson-Filho, P; Romualdo, PC; Sousa-Neto, MD1
Bambery, KR; Buenzli, PR; Duong, LT; Pearson, TA; Pennypacker, BL; Sims, NA; Tobin, MJ; Vrahnas, C1

Trials

1 trial(s) available for alendronate and odanacatib

ArticleYear
Effects of odanacatib on BMD and safety in the treatment of osteoporosis in postmenopausal women previously treated with alendronate: a randomized placebo-controlled trial.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:12

    Topics: Aged; Alendronate; Biomarkers; Biphenyl Compounds; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Calcium, Dietary; Cathepsin K; Cholecalciferol; Combined Modality Therapy; Dietary Supplements; Double-Blind Method; Drug Monitoring; Female; Humans; Medication Adherence; Middle Aged; Osteoporosis, Postmenopausal; Patient Dropouts; Protease Inhibitors

2013

Other Studies

12 other study(ies) available for alendronate and odanacatib

ArticleYear
Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011, Volume: 26, Issue:2

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Cathepsin K; Densitometry; Dose-Response Relationship, Drug; Estradiol; Female; Femur; Haversian System; Rabbits

2011
High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate.
    Bone, 2013, Volume: 56, Issue:2

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone Density; Bone Density Conservation Agents; Finite Element Analysis; Macaca mulatta; Ovariectomy; Radius; Tomography, X-Ray Computed

2013
Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.
    Bone, 2013, Volume: 56, Issue:2

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Female; Haplorhini; Hip Joint; Ovariectomy; Radiography; Spine

2013
The bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbits.
    Calcified tissue international, 2014, Volume: 94, Issue:2

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone and Bones; Bone Density Conservation Agents; Bone Remodeling; Bone Resorption; Female; Osteoclasts; Osteogenesis; Ovariectomy; Rabbits

2014
The effect of cathepsin K inhibitor on osteoclastic activity compared to alendronate and enamel matrix protein.
    Dental traumatology : official publication of International Association for Dental Traumatology, 2015, Volume: 31, Issue:3

    Topics: Alendronate; Animals; Biphenyl Compounds; Cathepsin K; Cells, Cultured; Dental Enamel Proteins; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice; Osteoclasts; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha

2015
Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs.
    Biochemical and biophysical research communications, 2015, Jun-26, Volume: 462, Issue:2

    Topics: Alendronate; Animals; Becaplermin; Biphenyl Compounds; Bone Remodeling; Cathepsin K; Cell Differentiation; Cysteine Proteinase Inhibitors; Gene Expression; Lysophospholipids; Mice; Mice, Inbred C57BL; Osteoclasts; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; RNA, Messenger; Sphingosine

2015
Odanacatib increases mineralized callus during fracture healing in a rabbit ulnar osteotomy model.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2016, Volume: 34, Issue:1

    Topics: Alendronate; Animals; Biphenyl Compounds; Bony Callus; Calcification, Physiologic; Female; Fracture Healing; Osteotomy; Rabbits; Random Allocation; Ulna

2016
Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, Volume: 31, Issue:3

    Topics: Alendronate; Animals; Biomechanical Phenomena; Biphenyl Compounds; Bone Density; Bone Diseases, Metabolic; Calcification, Physiologic; Cancellous Bone; Cortical Bone; Crystallization; Diaphyses; Drugs, Investigational; Estrogens; Female; Femur; Lumbar Vertebrae; Osteoblasts; Osteoclasts; Osteoporosis; Parathyroid Hormone; Rabbits

2016
Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, Volume: 31, Issue:4

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone Resorption; Female; Gene Expression Regulation; Macaca mulatta; Osteoclasts; Ovariectomy

2016
Effects of long term treatment with high doses of odanacatib on bone mass, bone strength, and remodeling/modeling in newly ovariectomized monkeys.
    Bone, 2016, Volume: 88

    Topics: Absorptiometry, Photon; Alendronate; Animals; Biomechanical Phenomena; Biphenyl Compounds; Bone and Bones; Bone Density; Bone Remodeling; Cancellous Bone; Cortical Bone; Densitometry; Dose-Response Relationship, Drug; Female; Macaca mulatta; Organ Size; Ovariectomy; Regression Analysis; Tomography, X-Ray Computed

2016
The effect of ovariectomy and 2 antiresorptive therapeutic agents on bone response in rats: A 3-dimensional imaging analysis.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2018, Volume: 126, Issue:3

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone Density; Female; Femur; Imaging, Three-Dimensional; Maxilla; Ovariectomy; Phenotype; Random Allocation; Rats; Rats, Wistar; X-Ray Microtomography

2018
Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits.
    Calcified tissue international, 2018, Volume: 103, Issue:6

    Topics: Alendronate; Animals; Biphenyl Compounds; Bone and Bones; Bone Density Conservation Agents; Bone Remodeling; Calcification, Physiologic; Female; Osteogenesis; Ovariectomy; Parathyroid Hormone; Rabbits

2018