alendronate has been researched along with mevalonic acid in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Coxon, FP; Graham, R; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, G | 1 |
| Benford, HL; Coxon, FP; Rogers, MJ; Russell, RG | 1 |
| Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
| Halasy-Nagy, JM; Masarachia, PJ; Reszka, AA; Rodan, GA | 1 |
| Fliesler, SJ; Keller, RK | 1 |
| Bergstrom, JD; Bostedor, RG; Masarachia, PJ; Reszka, AA; Rodan, G | 1 |
| Fisher, JE; Reszka, AA; Rodan, GA | 1 |
| Härkönen, PL; Lakkakorpi, PT; Väänänen, HK; Virtanen, SS | 1 |
| Komatsu, S; Ohta, T; Tokutake, N | 1 |
| Mönkkönen, J; Ollikainen, J; Taskinen, M; Töyräs, A | 1 |
| Andela, VB; O'Keefe, RJ; Pirri, M; Puzas, EJ; Rosenblatt, JD; Rosier, RN; Schwarz, EM | 1 |
| Andela, VB | 1 |
| Deng, X; Endo, Y; Funayama, H; Sasano, T; Sugawara, S; Yamaguchi, K; Yu, Z | 1 |
| Arizono, H; Azuma, Y; Nakamura, K; Ohta, T; Okaniwa, M; Shimizu, T; Taniguchi, T; Uchida, S | 1 |
| Inaba, M; Nishizawa, Y; Yamada, S | 1 |
| Crovella, S; Paoluzzi, E; Pontillo, A | 1 |
| Pazianas, M | 1 |
| Crovella, S; Girardelli, M; Marcuzzi, A; Piscianz, E; Pontillo, A | 1 |
| Fu, WZ; Gu, JM; He, JW; Hu, WW; Hu, YQ; Li, M; Liu, YJ; Shao, C; Wang, C; Yue, H; Zhang, H; Zhang, ZL; Zheng, H | 1 |
| Aoki, F; Hara, K; Kurabayashi, M; Maeno, T; Masubuchi, H; Nagai, R; Nishimura, S; Ogata, F; Suga, T; Ueno, M; Yamaguchi, K | 1 |
| Crovella, S; Girardelli, M; Kleiner, G; Knowles, A; Marcuzzi, A; Tricarico, PM; Valencic, E | 1 |
| Fu, G; Jiang, W; Lai, D; Lv, X; Rong, X; Xu, S; Yang, Y | 1 |
| Marcuzzi, A; Melloni, E; Rimondi, E; Secchiero, P; Tommasini, A; Valencic, E | 1 |
4 review(s) available for alendronate and mevalonic acid
| Article | Year |
|---|---|
[Pharmacological and clinical properties of alendronate sodium hydrate].
Topics: Alendronate; Animals; Bone Density; Bone Resorption; Clinical Trials as Topic; Depression, Chemical; Fractures, Bone; GTP-Binding Proteins; Humans; Mevalonic Acid; Osteoclasts; Osteoporosis; Protein Prenylation | 2002 |
The mevalonate synthesis pathway as a therapeutic target in cancer.
Topics: Acute-Phase Proteins; Alendronate; Alkyl and Aryl Transferases; Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Polyisoprenyl Phosphates; Tumor Cells, Cultured | 2003 |
[Influence on atherosclerosis of improvement of bone mineral density after medication for osteoporosis].
Topics: Alendronate; Apolipoprotein A-I; Arthritis, Rheumatoid; Atherosclerosis; Bone and Bones; Bone Density; Bone Density Conservation Agents; Cholesterol, HDL; Humans; Mevalonic Acid; Osteoporosis | 2007 |
Osteonecrosis of the jaw and the role of macrophages.
Topics: Alendronate; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bone Density Conservation Agents; Denosumab; Diphosphonates; Etidronic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibandronic Acid; Imidazoles; Indoles; Jaw Diseases; Macrophages; Magnetic Resonance Imaging; Mevalonic Acid; Monocytes; Mouth Mucosa; Osteoclasts; Osteomyelitis; Osteonecrosis; Positron-Emission Tomography; Pyrroles; Radiography, Panoramic; RANK Ligand; Risedronic Acid; Risk Factors; Signal Transduction; Sunitinib; Tomography, X-Ray Computed; Vitamin D; Zoledronic Acid | 2011 |
19 other study(ies) available for alendronate and mevalonic acid
| Article | Year |
|---|---|
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
Topics: Alendronate; Animals; Apoptosis; Bone Resorption; Cells, Cultured; Clodronic Acid; Diphosphonates; Enzyme Inhibitors; Etidronic Acid; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Macrophages; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; Protein Processing, Post-Translational; ras Proteins; Risedronic Acid; Structure-Activity Relationship | 1998 |
Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
Topics: Alendronate; Animals; Apoptosis; Carbon Radioisotopes; Caspase 3; Caspases; Cell Line; Cycloheximide; Diphosphonates; Enzyme Activation; Enzyme Inhibitors; Lovastatin; Macrophages; Mevalonic Acid; Mice; Protein Biosynthesis; Protein Synthesis Inhibitors | 1998 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase.
Topics: Alendronate; Animals; Apoptosis; Calcium Channel Blockers; Caspase Inhibitors; Caspases; Clodronic Acid; Diphosphonates; Diterpenes; Enzyme Activation; Etidronic Acid; Macrophage Colony-Stimulating Factor; Male; MAP Kinase Kinase Kinases; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoclasts; Protein Prenylation; Protein Serine-Threonine Kinases; Risedronic Acid; Signal Transduction; Staurosporine; Time Factors | 1999 |
Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway.
Topics: Alendronate; Alkyl and Aryl Transferases; Animals; Chromatography, High Pressure Liquid; Cytosol; Geranyltranstransferase; Hemiterpenes; Kinetics; Liver; Male; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 1999 |
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
Topics: Alendronate; Alkyl and Aryl Transferases; Animals; Carbon-Carbon Double Bond Isomerases; Diphosphonates; Enzyme Inhibitors; Farnesyltranstransferase; Geranyltranstransferase; Hemiterpenes; Humans; In Vitro Techniques; Kinetics; Lipids; Liver; Male; Mevalonic Acid; Osteoclasts; Pamidronate; Protein Prenylation; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2000 |
In vivo effects of bisphosphonates on the osteoclast mevalonate pathway.
Topics: Alendronate; Alkyl and Aryl Transferases; Animals; Bone Resorption; Diphosphonates; Enzyme Inhibitors; Etidronic Acid; Geranyltranstransferase; Hydroxymethylglutaryl CoA Reductases; Ibandronic Acid; Male; Mevalonic Acid; Osteoclasts; Rats; Rats, Sprague-Dawley; Risedronic Acid | 2000 |
Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway.
Topics: Alendronate; Antimetabolites; Bone Neoplasms; Cell Movement; Clodronic Acid; Dose-Response Relationship, Drug; Humans; Male; Mevalonic Acid; Neoplasm Invasiveness; Prostatic Neoplasms; Tumor Cells, Cultured | 2002 |
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro.
Topics: Alendronate; Animals; Cell Division; Cell Line; Diterpenes; Farnesol; Lipopolysaccharides; Macrophages; Mevalonic Acid; Mice | 2003 |
Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of huma
Topics: Alendronate; Humans; Male; Mevalonic Acid; Neoplasm Invasiveness; Prostatic Neoplasms | 2004 |
Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Clodronic Acid; Female; Histidine Decarboxylase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1alpha; Interleukin-1beta; Liposomes; Liver; Lung; Macrophages; Mevalonic Acid; Mice; Mice, Knockout; Peritoneal Cavity; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2007 |
[Pharmacological and clinical profile of once weekly alendronate for the treatment of osteoporosis (Fosamac 35 mg/Bonalon 35 mg)].
Topics: Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Resorption; Double-Blind Method; Esophagus; Female; Humans; Mevalonic Acid; Osteoclasts; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic | 2007 |
The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency.
Topics: Alendronate; Carrier Proteins; Child; Female; Humans; Inflammation; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Metabolic Networks and Pathways; Mevalonate Kinase Deficiency; Mevalonic Acid; NLR Family, Pyrin Domain-Containing 3 Protein; Up-Regulation; Young Adult | 2010 |
Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes.
Topics: Alendronate; Animals; Apoptosis; Biomarkers; Biosynthetic Pathways; Caspase 1; Caspase 3; Caspase Inhibitors; Cell Line; Cell Survival; Enzyme Activation; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mevalonic Acid; Mice; Monocytes; Necrosis; Oligopeptides; Terpenes | 2011 |
Genetic polymorphisms in the mevalonate pathway affect the therapeutic response to alendronate treatment in postmenopausal Chinese women with low bone mineral density.
Topics: Aged; Alendronate; Alleles; Asian People; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Female; Haplotypes; Humans; Lumbar Vertebrae; Mevalonic Acid; Osteoporosis; Phosphotransferases (Alcohol Group Acceptor); Polymorphism, Single Nucleotide; Postmenopause | 2015 |
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages.
Topics: Administration, Inhalation; Aerosols; Alendronate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Apoptosis; Bone Density Conservation Agents; Bronchoalveolar Lavage Fluid; Caspase 3; CD11b Antigen; CD11c Antigen; Cell Movement; Contrast Media; Drug Repositioning; Gene Expression; Lung; Macrophages, Alveolar; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; NF-kappa B; Pancreatic Elastase; Phagocytosis; Pulmonary Emphysema; Signal Transduction | 2015 |
Alendronate, a double-edged sword acting in the mevalonate pathway.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Apoptosis; Biosynthetic Pathways; Cell Line; Cytokines; Humans; Lipopolysaccharides; Mevalonic Acid; Mice; Monocytes; Phosphotransferases (Alcohol Group Acceptor) | 2015 |
Inhibition of mevalonate pathway prevents ischemia-induced cardiac dysfunction in rats via RhoA-independent signaling pathway.
Topics: Alendronate; Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathy, Dilated; Cell Line; Disease Models, Animal; Geranyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Rosuvastatin Calcium; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tacrolimus Binding Proteins; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Biosynthetic Pathways; Cell Death; Cell Shape; Farnesyl-Diphosphate Farnesyltransferase; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Mitochondria; Oxazepines; Piperidines; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2021 |