alendronate and methotrexate

alendronate has been researched along with methotrexate in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (27.78)29.6817
2010's12 (66.67)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Gündüz, OH; Ozoran, K; Uçan, H; Yilmaz, L; Yücel, M1
Ambler, GR; Chaitow, J; McDonald, DW; Ouvrier, RA; Rogers, M1
Clemente, DA; Damron, TA; Horton, JA; Margulies, BS; Murray, GM; Spadaro, JA; Strauss, JA1
Kaneko, F; Nakamura, K; Oyama, N; Satoh, M; Yamada, H1
Bargagli, E; Bertelli, P; Gonnelli, S; Olivieri, C; Penza, F; Rottoli, P; Volterrani, L1
Fett, N; Liu, RH1
Tu, J; Von Nida, J1
Abrahamsen, B; Andersen, LS; Ellingsen, T; Hansen, I; Hansen, MS; Hetland, ML; Hyldstrup, L; Hørslev-Petersen, K; Jensen, TW; Junker, P; Jurik, AG; Langdahl, B; Lauridsen, UB; Lindegaard, H; Lottenburger, T; Pedersen, JK; Pødenphant, J; Skjødt, H; Stengaard-Petersen, K; Svendsen, AJ; Tarp, U; Vestergaard, A; Zerahn, B; Østergaard, M1
Krause, ML; Lehman, JS; Warrington, KJ1
Adams, L; Alsalleeh, F; Bavitz, B; Keippel, J1
Kang, YS; Lee, NY1
Chu, W; Cui, S; Huang, Y; Liao, Y; Yan, M; Yang, C; Zhang, X; Zhao, C1
Chen, S; Fan, S; Liu, G; Qin, A; Sun, X; Tang, P; Xie, Z; Zhang, J; Zhu, P1
Gao, C; Wang, M; Yan, C; Zhu, P1

Reviews

3 review(s) available for alendronate and methotrexate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Rare localizations of bone sarcoidosis: two case reports and review of the literature.
    Rheumatology international, 2011, Volume: 31, Issue:11

    Topics: Alendronate; Bone Diseases; Bone Neoplasms; Diagnosis, Differential; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Methotrexate; Methylprednisolone; Middle Aged; Osteolysis; Radiography; Rare Diseases; Ribs; Sarcoidosis; Skull; Spine; Treatment Outcome

2011
Multicentric reticulohistiocytosis with dermatomyositis-like features: a more common disease presentation than previously thought.
    Dermatology (Basel, Switzerland), 2011, Volume: 222, Issue:2

    Topics: Alendronate; Antineoplastic Protocols; Arthritis; Breast Neoplasms; Combined Modality Therapy; Dermatologic Agents; Dermatomyositis; Diagnosis, Differential; Drug Therapy, Combination; Female; Histiocytosis; Humans; Lymphatic Metastasis; Mediastinal Neoplasms; Methotrexate; Middle Aged; Prednisone

2011

Trials

2 trial(s) available for alendronate and methotrexate

ArticleYear
Alendronate in rheumatoid arthritis patients treated with methotrexate and glucocorticoids.
    Rheumatology international, 2001, Volume: 20, Issue:2

    Topics: Absorptiometry, Photon; Aged; Alendronate; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Calcium; Clinical Chemistry Tests; Drug Therapy, Combination; Female; Hematologic Tests; Humans; Methotrexate; Middle Aged; Osteoporosis, Postmenopausal; Prednisolone; Treatment Outcome

2001
Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:6

    Topics: Adult; Aged; Alendronate; Antirheumatic Agents; Arthritis, Rheumatoid; Betamethasone; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Resorption; Cyclosporine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Young Adult

2014

Other Studies

13 other study(ies) available for alendronate and methotrexate

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Rapid improvement of calcinosis in juvenile dermatomyositis with alendronate therapy.
    The Journal of rheumatology, 2005, Volume: 32, Issue:9

    Topics: Alendronate; Calcinosis; Child; Dermatomyositis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Methotrexate; Prednisone; Radiography; Risk Assessment; Severity of Illness Index; Treatment Outcome

2005
Density and structural changes in the bone of growing rats after weekly alendronate administration with and without a methotrexate challenge.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2006, Volume: 24, Issue:5

    Topics: Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Male; Methotrexate; Rats; Rats, Sprague-Dawley

2006
Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate.
    The Journal of dermatology, 2008, Volume: 35, Issue:3

    Topics: Adult; Alendronate; Anti-Inflammatory Agents; Bone Density Conservation Agents; Drug Therapy, Combination; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Methotrexate; Prednisolone

2008
Metastatic malignant melanoma and dermatomyositis: A paraneoplastic phenomenon.
    The Australasian journal of dermatology, 2011, Volume: 52, Issue:2

    Topics: Adult; Alendronate; Antibodies, Antinuclear; Calcium; Dermatologic Agents; Dermatomyositis; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Melanoma; Methotrexate; Paraneoplastic Syndromes; Positron-Emission Tomography; Prednisolone; Skin Neoplasms; Treatment Outcome; Vitamin D

2011
Multicentric reticulohistiocytosis can mimic rheumatoid arthritis.
    The Journal of rheumatology, 2014, Volume: 41, Issue:4

    Topics: Alendronate; Arthritis, Rheumatoid; Biopsy, Needle; Diagnosis, Differential; Drug Therapy, Combination; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Hydroxychloroquine; Immunohistochemistry; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome

2014
Bisphosphonate-associated osteonecrosis of jaw reoccurrence after methotrexate therapy: a case report.
    Journal of endodontics, 2014, Volume: 40, Issue:9

    Topics: Aged; Alendronate; Amoxicillin; Anti-Bacterial Agents; Apicoectomy; Arthritis, Rheumatoid; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Drug Interactions; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Methotrexate; Osteoporosis; Tooth Extraction; Wound Healing

2014
The Changes by Hypoxia Inducible Factor-1alpha (HIF-1α) on Taurine Uptake in Brain Capillary Endothelial Cells at High Glucose Conditions.
    Advances in experimental medicine and biology, 2015, Volume: 803

    Topics: Alendronate; Animals; Blood-Brain Barrier; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Methotrexate; Rats; Receptors, Neurotransmitter; Taurine; Vascular Endothelial Growth Factor A

2015
Calcium phosphate nanoparticles functionalized with alendronate-conjugated polyethylene glycol (PEG) for the treatment of bone metastasis.
    International journal of pharmaceutics, 2017, Jan-10, Volume: 516, Issue:1-2

    Topics: Alendronate; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Calcium Phosphates; Cell Line; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Delivery Systems; Durapatite; Female; Humans; Methotrexate; Mice; Nanoparticles; Photoelectron Spectroscopy; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution

2017
Bone-targeted methotrexate-alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Alendronate; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Collagen; Cytokines; Drug Therapy, Combination; Female; Inflammation; Male; Methotrexate; Mice; Mice, Inbred C57BL; Muramidase; Osteoclasts; Osteogenesis; Rats; Rats, Wistar

2018
Preparation, characterization and in vitro antitumor activity evaluation of hyaluronic acid-alendronate-methotrexate nanoparticles.
    International journal of biological macromolecules, 2021, Jan-01, Volume: 166

    Topics: A549 Cells; Alendronate; Antimetabolites, Antineoplastic; Cell Proliferation; Endocytosis; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronic Acid; Methotrexate; Nanoparticles

2021