alendronate has been researched along with geranylgeraniol in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
| Auriola, S; Benford, HL; Frith, JC; Mönkkönen, J; Rogers, MJ | 1 |
| Halasy-Nagy, JM; Masarachia, PJ; Reszka, AA; Rodan, GA | 1 |
| Ikebuchi, Y; Kawagishi, R; Morishige, K; Murata, Y; Sawada, K; Tahara, M; Tasaka, K | 1 |
| Phipps, RJ; Scutt, A; Still, K | 1 |
| Mönkkönen, J; Ollikainen, J; Taskinen, M; Töyräs, A | 1 |
| Fisher, JE; Glantschnig, H; Reszka, AA; Rodan, GA; Wesolowski, G | 1 |
| De Leo, L; Decorti, G; Marcuzzi, A; Not, T; Pontillo, A; Tommasini, A; Ventura, A | 1 |
| Kazmers, NH; Ma, SA; Stern, PH; Yoshida, T | 1 |
| Chen, SQ; Fu, GS; Jiang, CY; Lv, X; Wang, MH; Ye, Y; Zhu, J | 1 |
| Korjai, N; Matchimapiro, M; Patntirapong, S; Sungkaruk, P; Suthamporn, Y | 1 |
11 other study(ies) available for alendronate and geranylgeraniol
| Article | Year |
|---|---|
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs.
Topics: Adenosine Triphosphate; Alendronate; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cells, Cultured; Diphosphonates; Diterpenes; Endopeptidases; Enzyme Activation; Farnesol; Mice; Protein Prenylation | 1999 |
Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase.
Topics: Alendronate; Animals; Apoptosis; Calcium Channel Blockers; Caspase Inhibitors; Caspases; Clodronic Acid; Diphosphonates; Diterpenes; Enzyme Activation; Etidronic Acid; Macrophage Colony-Stimulating Factor; Male; MAP Kinase Kinase Kinases; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoclasts; Protein Prenylation; Protein Serine-Threonine Kinases; Risedronic Acid; Signal Transduction; Staurosporine; Time Factors | 1999 |
Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho.
Topics: Alendronate; Cell Movement; Cell Survival; Cytoskeletal Proteins; Diterpenes; Drug Interactions; Enzyme Activation; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Myosin Light Chains; Ovarian Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Tumor Cells, Cultured; Tyrosine | 2002 |
Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro.
Topics: Alendronate; Animals; Bone and Bones; Bone Marrow Cells; Cell Survival; Diphosphonates; Diterpenes; Etidronic Acid; Farnesol; Fibroblasts; Models, Animal; Rats; Rats, Wistar; Risedronic Acid; Stromal Cells | 2003 |
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro.
Topics: Alendronate; Animals; Cell Division; Cell Line; Diterpenes; Farnesol; Lipopolysaccharides; Macrophages; Mevalonic Acid; Mice | 2003 |
M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
Topics: Acid Phosphatase; Actins; Adaptor Proteins, Signal Transducing; Alendronate; Alkyl and Aryl Transferases; Animals; Apoptosis; Blotting, Western; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Caspase 3; Caspase 9; Caspases; Cell Cycle Proteins; Cell Survival; Collagen; Collagen Type I; Cytokines; Diterpenes; Enzyme Inhibitors; Eukaryotic Initiation Factors; Immunohistochemistry; Interleukin-1; Isoenzymes; Macrophage Colony-Stimulating Factor; Membrane Glycoproteins; Mice; Models, Biological; NF-kappa B; Osteoclasts; Peptides; Phosphoproteins; Protein Kinases; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Serine-Threonine Kinase 3; Signal Transduction; Sirolimus; Tartrate-Resistant Acid Phosphatase; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2003 |
Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Acyclic Monoterpenes; Alendronate; Animals; Disease Models, Animal; Diterpenes; Farnesol; Inflammation; Male; Mevalonate Kinase Deficiency; Mice; Mice, Inbred BALB C; Terpenes | 2008 |
Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells.
Topics: Actins; Alendronate; Alkyl and Aryl Transferases; Amides; Animals; Cattle; Cell Line; Cytoskeleton; Diphosphonates; Diterpenes; Enzyme Inhibitors; Focal Adhesions; Imaging, Three-Dimensional; Mice; Models, Biological; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Stress Fibers | 2009 |
Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts.
Topics: Alendronate; Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Depression, Chemical; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Fibrosis; Male; Molecular Targeted Therapy; Myocardium; Rats, Wistar; rho-Associated Kinases; Signal Transduction | 2015 |
Geranylgeraniol reverses alendronate-induced MC3T3 cell cytotoxicity and alteration of osteoblast function via cell cytoskeletal maintenance.
Topics: Alendronate; Cytoskeleton; Diterpenes; Humans; Maintenance; Osteoblasts | 2021 |