alendronate has been researched along with clodronic acid in 81 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (3.70) | 18.7374 |
1990's | 26 (32.10) | 18.2507 |
2000's | 31 (38.27) | 29.6817 |
2010's | 18 (22.22) | 24.3611 |
2020's | 3 (3.70) | 2.80 |
Authors | Studies |
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Lecouvey, M; Monteil, M; Puljula, E; Turhanen, P; Vepsäläinen, J; Weisell, J | 1 |
Almeida Paz, FA; Barbosa, JS; Braga, SS | 1 |
Bonjour, JP; Buchs, B; Rizzoli, R | 1 |
Fleisch, H; Janner, M; Mühlbauer, RC | 1 |
Bauss, F; Bosies, E; Fleisch, H; Janner, M; Mühlbauer, RC; Schenk, R; Strein, K | 1 |
Warrell, RP | 1 |
Adami, S; Garavelli, S; Guarrera, G; Lo Cascio, V; Montesanti, F; Rosini, S; Salvagno, G | 1 |
Ascari, E; Attardo-Parrinello, G; Crema, F; Fiorentini, ML; Merlini, G; Pavesi, F | 1 |
Bettschen-Camin, L; Felix, R; Fleisch, H; Stronski, SA; Trechsel, U; Wetterwald, A | 1 |
Alfano, FS; Basini, G; Campanini, C; Fantuzzi, M; Gatti, C; Girasole, G; Passeri, M; Pedrazzoni, M | 1 |
Koyano, H; Schimizu, T; Shishiba, Y | 1 |
Bell, C; Brooks, MA; Chamberlin, SD; Forsyth, RJ; Ip, DP; Tsai, EW | 1 |
Aloisi, R; Benetti, D; Fantozzi, R; Mian, M; Rosini, S | 1 |
Collin, P; Fleisch, H; Guenther, HL; Martin, TJ; Sahni, M | 1 |
Hirvonen, MR; Makkonen, N; Mönkkönen, J; Savolainen, K; Teräväinen, T | 1 |
Antic, VN; Fleisch, H; Mühlbauer, RC | 1 |
Kawano, S; Moriyama, H; Nagai, H; Naito, M; Takatsuka, H; Takei, Y; Umezu, H; Yamamoto, T; Zhu, H | 1 |
Licata, AA | 1 |
Body, JJ; Coleman, RE; Piccart, M | 1 |
Adachi, H; Hirafuji, M; Igarashi, K; Mitani, H; Shinoda, H | 1 |
Fleisch, HA | 1 |
Blackburn, GM; Frith, JC; Mönkkönen, J; Rogers, MJ; Russell, RG | 1 |
Adami, S | 1 |
Girasole, G; Giuliani, N; Passeri, G; Pedrazzoni, M | 1 |
Coxon, FP; Graham, R; Hughes, DE; Luckman, SP; Rogers, MJ; Russell, G | 1 |
Knowles, S; Phillips, E; Shear, NH; Weber, E | 1 |
Gennari, C; Reginster, JY | 1 |
Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
Azhayeva, E; Frith, JC; Makkonen, N; Mönkkönen, J; Rogers, MJ; Salminen, A; Urtti, A | 1 |
Halasy-Nagy, JM; Masarachia, PJ; Reszka, AA; Rodan, GA | 1 |
Fallon, JJ; Goldstein, MF; Harning, R | 1 |
Berenson, J; Hortobagyi, G; Lipton, A; Major, PP | 1 |
del Puente, A; Ferrara, G; Itto, E; Oriente, P; Scognamiglio, A | 1 |
Watts, NB | 1 |
Auriola, S; Frith, JC; Mönkkönen, H; Mönkkönen, J; Rogers, MJ | 1 |
Aspenberg, P; Astrand, J | 1 |
Härkönen, PL; Lakkakorpi, PT; Väänänen, HK; Virtanen, SS | 1 |
Crisafulli, A; Di Pietro, C; Frisina, N; Gaudio, A; Lasco, A; Meo, A; Morabito, N | 1 |
Frith, JC; Rogers, MJ | 1 |
Epstein, M; Joshua, F; Major, G | 1 |
Endo, Y; Funayama, H; Mayanagi, H; Monma, Y | 1 |
Aoyagi, S; Itoh, F; Kogo, H; Kojima, M; Kusama, H | 1 |
Hershman, D; Narayanan, R | 1 |
Boos, J; Lanvers-Kaminsky, C; Vorotnjak, M | 1 |
Abrahamsen, B; Brixen, KT; Kassem, MS; Mosekilde, L | 1 |
Endo, Y; Funayama, H; Mayanagi, H; Monma, Y; Ohsako, M; Sugawara, S | 1 |
Azzarello, G; Balducci, E; Crepaldi, G; Dalle Carbonare, L; Giannini, S; Realdi, G; Valenti, MT; Vinante, O | 1 |
Conroy, M; Cree, IA; Fernando, A; Knight, LA; Kurbacher, CM; Polak, M | 1 |
Deng, X; Endo, Y; Funayama, H; Kuroishi, T; Sasano, T; Sugawara, S; Yu, Z | 1 |
Deng, X; Endo, Y; Funayama, H; Iwakura, Y; Sasano, T; Shoji, N; Sugawara, S; Yu, Z | 1 |
Coxon, FP; Crockett, JC; Rogers, MJ; Thompson, K | 1 |
Franke, HR; Verdijk, R; Vermes, I; Wolbers, F | 1 |
Langdahl, B; Mosekilde, L; Vestergaard, P | 1 |
Deng, X; Endo, Y; Funayama, H; Sasano, T; Sugawara, S; Yamaguchi, K; Yu, Z | 1 |
Azzarello, G; Balducci, E; Bertoldo, F; Dalle Carbonare, L; Fracalossi, A; Lo Cascio, V; Valenti, MT; Vinante, O | 1 |
Pritchard, KI | 1 |
Dulea, C; Gherase, A; Savu, SR; Silvestro, L; Tarcomnicu, I | 1 |
Honda, S; Imai, H; Nagai, T; Negi, A | 1 |
Alva, D; Cesareo, R; Contini, S; De Rosa, B; Iozzino, M; Lauria, A; Mallardo, L; Napolitano, C; Orsini, A; Reda, G | 1 |
Márton, I; Redl, P; Udvardy, E | 1 |
Deng, X; Endo, Y; Kiyoura, Y; Tamai, R | 1 |
Rogers, HL; Rogers, MJ; Sutherland, KA; Tosh, D | 1 |
Prutthiwanasan, B; Suntornsuk, L | 1 |
Endo, Y; Nagai, Y; Oizumi, T; Okada, S; Shikama, Y; Shimauchi, H; Sugawara, S | 1 |
Lamprecht, A; Ulbrich, W | 1 |
Aro, HT; Heervä, E; Peltonen, J; Peltonen, S; Svedström, E; Väänänen, K | 1 |
Carson, DA; Cho, JS; Corr, M; Crain, B; Hayashi, T; Miller, LS; Norton, JT | 1 |
Bianco, AM; Crovella, S; Decorti, G; Marcuzzi, A; Monasta, L; Piscianz, E; Vuch, J; Zanin, V | 1 |
Hayden, RS; Kaplan, DL; Vollrath, M | 1 |
Brennan, PA; Jenei, V; McLeod, NM; Moutasim, KA; Thomas, G | 1 |
Bouxsein, ML; Brooks, DJ; Demay, MB; Louis, L; Zhu, ED | 1 |
De Luna-Bertos, E; García-Martínez, O; Manzano-Moreno, FJ; Ramos-Torrecillas, J; Ruiz, C | 1 |
Bhardwaj, A; Osunkwo, I; Sinha, NK; Swe, KM | 1 |
Mészaros, Á; Veszelyné Kotán, E | 2 |
Danenberg, HD; Golomb, G; Grad, E; Gutman, D; Nordling-David, MM; Zolotarevsky, K | 1 |
Al-Nawas, B; Jung, J; Kwon, YD; Pabst, AM; Park, JS; Righesso, L; Walter, C | 1 |
García-Martínez, O; Illescas-Montes, R; Manzano-Moreno, FJ; Melguizo-Rodríguez, L; Ramos-Torrecillas, J; Ruiz, C | 1 |
Bond, AM; Flynn, D; Keyes, TE; MacConnell, N; Maher, S; McDaid, D; Ramadurai, S; Sarangi, NK | 1 |
Adams, A; Heidenreich, A; Jakob, T; Kuhr, K; Macherey, S; Monsef, I; Skoetz, N; Tesfamariam, YM | 1 |
Bhardwaj, A; Sinha, NK; Swe, KMM | 1 |
19 review(s) available for alendronate and clodronic acid
Article | Year |
---|---|
Bisphosphonates, Old Friends of Bones and New Trends in Clinics.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Diseases; Diphosphonates; Drug Compounding; Drug Delivery Systems; Humans | 2021 |
Hypercalcemia and bone metastases in breast cancer.
Topics: Alendronate; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Diphosphonates; Etidronic Acid; Hypercalcemia; Neoplasm Proteins; Pamidronate; Parathyroid Hormone-Related Protein; Proteins; Transforming Growth Factors | 1990 |
Bisphosphonate therapy.
Topics: Alendronate; Animals; Bone Density; Bone Resorption; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Fractures, Bone; Humans; Osteoclasts; Osteoporosis; Osteoporosis, Postmenopausal; Pamidronate; Risedronic Acid | 1997 |
Use of bisphosphonates in cancer patients.
Topics: Alendronate; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Multiple Myeloma; Osteolysis; Pain; Pamidronate; Structure-Activity Relationship | 1996 |
Bisphosphonates: preclinical aspects and use in osteoporosis.
Topics: Alendronate; Animals; Bone Resorption; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Osteoporosis; Pamidronate | 1997 |
Bisphosphonates in prostate carcinoma.
Topics: Alendronate; Biomarkers; Bone Diseases; Bone Neoplasms; Bone Resorption; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Male; Neoplasm Invasiveness; Osteoclasts; Pain; Prostatic Neoplasms | 1997 |
Bisphosphonates and osteoporosis treatment in Italy.
Topics: Aged; Alendronate; Bone and Bones; Bone Density; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Fractures, Bone; Humans; Italy; Middle Aged; Osteoporosis; Osteoporosis, Postmenopausal; Safety | 1998 |
Chronic glucocorticoid therapy-induced osteoporosis in patients with obstructive lung disease.
Topics: Administration, Inhalation; Administration, Oral; Adult; Alendronate; Asthma; Bone Density; Bone Remodeling; Calcitonin; Clodronic Acid; Etidronic Acid; Fluorides; Glucocorticoids; Hormone Replacement Therapy; Humans; Lung Diseases, Obstructive; Osteoporosis; Prednisone; Time Factors | 1999 |
Oral bisphosphonates: A review of clinical use in patients with bone metastases.
Topics: Alendronate; Biological Availability; Bone Density; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Clodronic Acid; Diphosphonates; Double-Blind Method; Etidronic Acid; Humans; Ibandronic Acid; Imidazoles; Male; Multiple Myeloma; Pamidronate; Prostatic Neoplasms; Pyridines; Randomized Controlled Trials as Topic; Risedronic Acid; Zoledronic Acid | 2000 |
Treatment of osteoporosis with bisphosphonates.
Topics: Aged; Alendronate; Bone and Bones; Bone Density; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Pamidronate; Risedronic Acid | 2001 |
Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer.
Topics: Absorptiometry, Photon; Alendronate; Antineoplastic Agents; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Breast Neoplasms; Calcitonin; Calcium; Clodronic Acid; Diphosphonates; Drug Therapy, Combination; Estrogens; Etidronic Acid; Female; Humans; Imidazoles; Male; Osteoporosis; Prostatic Neoplasms; Quality of Life; Risedronic Acid; Risk Factors; Treatment Outcome; Vitamin D; Zoledronic Acid | 2004 |
[Pharmacological treatment of osteitis deformans (Paget's bone disease)].
Topics: Alendronate; Analgesics, Non-Narcotic; Antimetabolites; Calcitonin; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Osteitis Deformans; Pamidronate; Radionuclide Imaging; Risedronic Acid | 2005 |
Fracture prevention in postmenopausal women.
Topics: Aged; Alendronate; Bone Density Conservation Agents; Calcitonin; Calcium; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Fractures, Spontaneous; Hormone Replacement Therapy; Humans; Ibandronic Acid; Osteoporosis, Postmenopausal; Pamidronate; Parathyroid Hormone; Risedronic Acid; Selective Estrogen Receptor Modulators; Vitamin D | 2006 |
Evidence based medicine and effective interventions of pharmacological therapy for the prevention of osteoporotic fractures.
Topics: Alendronate; Bone Density Conservation Agents; Bone Resorption; Calcitonin; Clodronic Acid; Diphosphonates; Etidronic Acid; Evidence-Based Medicine; Female; Fractures, Bone; Humans; Ibandronic Acid; Organometallic Compounds; Osteoporosis, Postmenopausal; Risedronic Acid; Selective Estrogen Receptor Modulators; Teriparatide; Thiophenes; Vitamin D | 2007 |
[Osteonecrosis of the jaw developing during bisphosphonate treatment].
Topics: Alendronate; Anti-Infective Agents; Bone Density Conservation Agents; Bone Neoplasms; Bone Remodeling; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Ibandronic Acid; Imidazoles; Mandible; Mandibular Diseases; Oral Hygiene; Oral Surgical Procedures; Osteonecrosis; Patient Care Team; Referral and Consultation; Zoledronic Acid | 2008 |
Treatment for osteoporosis in people with ß-thalassaemia.
Topics: Adolescent; Adult; Alendronate; beta-Thalassemia; Bone Density; Bone Density Conservation Agents; Child; Clodronic Acid; Diphosphonates; Female; Femur Neck; Humans; Male; Middle Aged; Osteoporosis; Randomized Controlled Trials as Topic; Zinc Sulfate | 2016 |
[Therapeutic practice of bisphosphonate use and related pharmaceutical issues I].
Topics: Alendronate; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Neoplasms; Clodronic Acid; Diphosphonates; Fractures, Bone; Humans; Hungary; Ibandronic Acid; Imidazoles; Osteoporosis; Pamidronate; Risedronic Acid; Zoledronic Acid | 2016 |
Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.
Topics: Adult; Alendronate; Antineoplastic Agents, Hormonal; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Neoplasms; Clodronic Acid; Denosumab; Diphosphonates; Etidronic Acid; Humans; Male; Network Meta-Analysis; Pamidronate; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Quality of Life; Randomized Controlled Trials as Topic; RANK Ligand; Risedronic Acid; Zoledronic Acid | 2020 |
Treatment for osteoporosis in people with beta-thalassaemia.
Topics: Adult; Alendronate; beta-Thalassemia; Child; Clodronic Acid; Denosumab; Diphosphonates; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteoporosis; Pamidronate | 2023 |
6 trial(s) available for alendronate and clodronic acid
Article | Year |
---|---|
Effect of a single infusion of alendronate in malignant hypercalcaemia: dose dependency and comparison with clodronate.
Topics: Aged; Alendronate; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Dose-Response Relationship, Drug; Female; Humans; Hypercalcemia; Male; Middle Aged; Neoplasms | 1992 |
Hypercalcemia and bone metastases in breast cancer.
Topics: Alendronate; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Diphosphonates; Etidronic Acid; Hypercalcemia; Neoplasm Proteins; Pamidronate; Parathyroid Hormone-Related Protein; Proteins; Transforming Growth Factors | 1990 |
Effects of a new aminodiphosphonate (aminohydroxybutylidene diphosphonate) in patients with osteolytic lesions from metastases and myelomatosis. Comparison with dichloromethylene diphosphonate.
Topics: Adult; Aged; Aged, 80 and over; Alendronate; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Calcium; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Female; Humans; Hydroxyproline; Male; Middle Aged; Pain | 1987 |
Intramuscular clodronate in nonresponders to oral alendronate therapy for osteoporosis.
Topics: Absorptiometry, Photon; Administration, Oral; Aged; Alendronate; Alkaline Phosphatase; Analgesics, Non-Narcotic; Bone Density; Case-Control Studies; Clodronic Acid; Female; Femur Neck; Humans; Injections, Intramuscular; Middle Aged; Osteoporosis, Postmenopausal; Treatment Outcome | 2000 |
Bisphosphonates in the treatment of thalassemia-induced osteoporosis.
Topics: Absorptiometry, Photon; Adolescent; Adult; Alendronate; Analysis of Variance; beta-Thalassemia; Biomarkers; Bone Density; Bone Remodeling; Clodronic Acid; Diphosphonates; Female; Humans; Male; Osteoporosis; Placebo Effect | 2002 |
Bisphosphonate resistance in Paget's disease of bone.
Topics: Aged; Aged, 80 and over; Alendronate; Alkaline Phosphatase; Anti-Inflammatory Agents; Clodronic Acid; Diphosphonates; Drug Resistance; Humans; Injections, Intravenous; Middle Aged; Osteitis Deformans; Pamidronate | 2003 |
57 other study(ies) available for alendronate and clodronic acid
Article | Year |
---|---|
Structural requirements for bisphosphonate binding on hydroxyapatite: NMR study of bisphosphonate partial esters.
Topics: | 2015 |
Sodium EDTA enhances intestinal absorption of two bisphosphonates.
Topics: Administration, Oral; Alendronate; Analysis of Variance; Animals; Calcium; Clodronic Acid; Diphosphonates; Edetic Acid; Intestinal Absorption; Male; Rats; Rats, Inbred Strains | 1991 |
BM 21.0955, a potent new bisphosphonate to inhibit bone resorption.
Topics: Alendronate; Animals; Benzoates; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Etidronic Acid; Ibandronic Acid; Injections, Intravenous; Osteoclasts; Pamidronate; Rats; Retinoids; Risedronic Acid; Spectrophotometry, Atomic; Tetracycline; Thyroxine | 1991 |
Treatment of Paget's disease of bone with intravenous 4-amino-1-hydroxybutylidene-1,1-bisphosphonate.
Topics: Alendronate; Alkaline Phosphatase; Clodronic Acid; Diphosphonates; Drug Resistance; Humans; Hydroxyproline; Infusions, Intravenous; Osteitis Deformans | 1986 |
Bisphosphonates inhibit 1,25-dihydroxyvitamin D3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium of rat calvaria in vitro.
Topics: Alendronate; Animals; Calcitriol; Calcium-Binding Proteins; Clodronic Acid; Culture Techniques; Diphosphonates; DNA; Male; Osteoblasts; Osteocalcin; Proline; Rats; Rats, Inbred Strains; Skull | 1988 |
Acute effects of bisphosphonates on new and traditional markers of bone resorption.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alendronate; Amino Acids; Biomarkers; Bone and Bones; Bone Resorption; Clodronic Acid; Collagen; Collagen Type I; Diphosphonates; Female; Humans; Hydroxyproline; Injections, Intravenous; Male; Middle Aged; Osteitis Deformans; Osteoporosis; Peptides; Time Factors | 1995 |
The bisphosphonate dilemma.
Topics: Alendronate; Bone and Bones; Bone Neoplasms; Clodronic Acid; Diphosphonates; False Negative Reactions; Female; Humans; Hypercalcemia; Middle Aged; Parathyroid Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate | 1995 |
Determination of bisphosphonate drugs in pharmaceutical dosage formulations by ion chromatography with indirect UV detection.
Topics: Alendronate; Chromatography, Ion Exchange; Clodronic Acid; Diphosphonates; Etidronic Acid; Indicators and Reagents; Spectrophotometry, Ultraviolet | 1994 |
Effects of bisphosphonate derivatives on macrophage function.
Topics: Alendronate; Animals; Bone Diseases; Clodronic Acid; Diphosphonates; Glucuronidase; Lysosomes; Macrophages, Peritoneal; Phagocytosis; Rats; Superoxides | 1994 |
Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.
Topics: Alendronate; Animals; Animals, Newborn; Bone Resorption; Cell Line; Cells, Cultured; Clodronic Acid; Culture Media, Conditioned; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Ibandronic Acid; Kinetics; Osteoblasts; Pamidronate; Parathyroid Hormone; Rats; Rats, Wistar; Time Factors | 1993 |
Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro.
Topics: Alendronate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Clodronic Acid; Diphosphonates; Female; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Pamidronate | 1996 |
Effect of bisphosphonates on the increase in bone resorption induced by a low calcium diet.
Topics: Alendronate; Animals; Bone Resorption; Calcium; Calcium, Dietary; Clodronic Acid; Diphosphonates; Disease Models, Animal; Homeostasis; Ibandronic Acid; Male; Rats; Rats, Wistar; Tetracycline | 1996 |
Liposome-encapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro.
Topics: Alendronate; Animals; Apoptosis; Biotin; Clodronic Acid; DNA; DNA Nucleotidylexotransferase; Drug Carriers; Female; Gadolinium; Kupffer Cells; Liposomes; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Microscopy, Electron; Rats; Rats, Wistar; RNA; Uridine Triphosphate | 1996 |
Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1.
Topics: Alendronate; Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Cell Line; Clodronic Acid; Culture Media; Dinoprostone; Diphosphonates; DNA; Glycerophosphates; Mice; Osteoblasts; Pamidronate | 1997 |
Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.
Topics: Adenosine Triphosphate; Alendronate; Analgesics, Non-Narcotic; Apoptosis; Cell Survival; Cells, Cultured; Clodronic Acid; Diphosphonates; Humans; Liposomes; Microscopy, Fluorescence | 1997 |
Bisphosphonates inhibit IL-6 production by human osteoblast-like cells.
Topics: Alendronate; Analgesics, Non-Narcotic; Clodronic Acid; Etidronic Acid; Humans; Interleukin-1; Interleukin-6; Osteoblasts; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
Topics: Alendronate; Animals; Apoptosis; Bone Resorption; Cells, Cultured; Clodronic Acid; Diphosphonates; Enzyme Inhibitors; Etidronic Acid; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Macrophages; Mevalonic Acid; Mice; Osteoclasts; Protein Prenylation; Protein Processing, Post-Translational; ras Proteins; Risedronic Acid; Structure-Activity Relationship | 1998 |
Skin reactions associated with bisphosphonates: a report of 3 cases and an approach to management.
Topics: Adult; Alendronate; Antineoplastic Agents; Breast Neoplasms; Clodronic Acid; Diphosphonates; Drug Hypersensitivity; Etidronic Acid; Female; Humans; Middle Aged; Pamidronate; Skin Tests; Urticaria | 1998 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite.
Topics: Alendronate; Analgesics, Non-Narcotic; Animals; Arthritis, Rheumatoid; Cells, Cultured; Clodronic Acid; Cytokines; Diphosphonates; Drug Carriers; Electrophoresis, Polyacrylamide Gel; Liposomes; Macrophages; Mice; NF-kappa B; Nitric Oxide; Protein Biosynthesis; Transcription Factor AP-1 | 1999 |
Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase.
Topics: Alendronate; Animals; Apoptosis; Calcium Channel Blockers; Caspase Inhibitors; Caspases; Clodronic Acid; Diphosphonates; Diterpenes; Enzyme Activation; Etidronic Acid; Macrophage Colony-Stimulating Factor; Male; MAP Kinase Kinase Kinases; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoclasts; Protein Prenylation; Protein Serine-Threonine Kinases; Risedronic Acid; Signal Transduction; Staurosporine; Time Factors | 1999 |
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.
Topics: Adenosine Triphosphate; Alendronate; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Apoptosis; Bone Resorption; Capsules; Cells, Cultured; Clodronic Acid; Liposomes; Macrophages, Peritoneal; Osteoclasts; Protein Prenylation; Rabbits; rap1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley | 2001 |
Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.
Topics: Alendronate; Animals; Bone Plates; Bone Resorption; Clodronic Acid; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Joint Instability; Male; Osseointegration; Preoperative Care; Probability; Prostheses and Implants; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Tibia | 2002 |
Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway.
Topics: Alendronate; Antimetabolites; Bone Neoplasms; Cell Movement; Clodronic Acid; Dose-Response Relationship, Drug; Humans; Male; Mevalonic Acid; Neoplasm Invasiveness; Prostatic Neoplasms; Tumor Cells, Cultured | 2002 |
Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro.
Topics: Adenosine Triphosphate; Alendronate; Animals; Apoptosis; Blotting, Western; Bone Resorption; Cell Line; Cell Membrane; Cell Nucleus; Cells, Cultured; Clodronic Acid; Diphosphonates; Dose-Response Relationship, Drug; Ibandronic Acid; Macrophages; Mice; Microscopy, Fluorescence; Osteoclasts; Pinocytosis; Rabbits; Time Factors | 2003 |
Effects of weekly administrations of alendronate+clodronate on young mouse tibia: localized action at the proximal growth plate.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Calcium; Clodronic Acid; Drug Administration Schedule; Drug Therapy, Combination; Growth Plate; Male; Mice; Mice, Inbred BALB C; Radiography; Tibia | 2004 |
Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis.
Topics: Alendronate; Animals; Arthritis, Experimental; Bone and Bones; Clodronic Acid; Male; Osteogenesis; Rats; Rats, Inbred Lew | 2004 |
In vitro toxicity of bisphosphonates on human neuroblastoma cell lines.
Topics: Alendronate; Apoptosis; Cell Line, Tumor; Cell Proliferation; Clodronic Acid; Diphosphonates; Drug Screening Assays, Antitumor; Germany; Humans; Ibandronic Acid; Imidazoles; Neuroblastoma; Pamidronate; Time Factors; Zoledronic Acid | 2004 |
Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Antimetabolites; Bone and Bones; Bone Resorption; Clodronic Acid; Drug Interactions; Drug Therapy, Combination; Etidronic Acid; Histidine Decarboxylase; Inflammation; Male; Mice; Mice, Inbred BALB C | 2005 |
Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells.
Topics: Alendronate; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Clodronic Acid; Diphosphonates; DNA-Binding Proteins; Female; Gene Expression; Humans; Pamidronate; Telomerase; Tumor Cells, Cultured | 2005 |
Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Alendronate; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Caspase 3; Caspase 7; Caspases; Cell Line, Tumor; Cell Survival; Cisplatin; Clodronic Acid; Diphosphonates; Energy Metabolism; Female; Humans; Imidazoles; Inhibitory Concentration 50; Lung Neoplasms; Male; Melanoma; Middle Aged; Neoplasms; Neoplasms, Unknown Primary; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured; Zoledronic Acid | 2005 |
Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Aspirin; Bone Density Conservation Agents; Clodronic Acid; Dexamethasone; Histidine Decarboxylase; Inflammation; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Size; Radiography; Sclerosis; Spleen; Tibia | 2005 |
Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Clodronic Acid; Enzyme Induction; Female; Histidine Decarboxylase; Immunologic Factors; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2006 |
Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis.
Topics: Alendronate; Animals; Biological Transport; Calcium; Cell Line; Clodronic Acid; Cytosol; Egtazic Acid; Endocytosis; Flow Cytometry; Fluorescent Dyes; Kinetics; Macrophages; Mice; Microscopy, Confocal; Strontium | 2006 |
Differential effects of bisphosphonates on breast cancer cell lines.
Topics: Alendronate; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Clodronic Acid; Cyclin D1; Diphosphonates; DNA Fragmentation; Etidronic Acid; Female; Flow Cytometry; Humans; Ibandronic Acid; Imidazoles; Pamidronate; Risedronic Acid; RNA, Messenger; Zoledronic Acid | 2007 |
Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Clodronic Acid; Female; Histidine Decarboxylase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1alpha; Interleukin-1beta; Liposomes; Liver; Lung; Macrophages; Mevalonic Acid; Mice; Mice, Knockout; Peritoneal Cavity; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2007 |
Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro.
Topics: Alendronate; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Clodronic Acid; Diphosphonates; Female; Gene Expression Regulation, Neoplastic; Humans; Pamidronate; Telomerase | 2007 |
Bisphosphonates: are they standard of care for the treatment of breast cancer?
Topics: Alendronate; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Female; Humans; Randomized Controlled Trials as Topic | 2007 |
Development and application of a high-performance liquid chromatography-mass spectrometry method to determine alendronate in human urine.
Topics: Alendronate; Biological Availability; Chromatography, High Pressure Liquid; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Mass Spectrometry; Pamidronate; Reference Standards | 2007 |
Antiangiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice.
Topics: Alendronate; Angiogenesis Inhibitors; Animals; Cell Culture Techniques; Choroid; Choroidal Neovascularization; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Fluorescein Angiography; Injections, Intraperitoneal; Integrin alphaV; Integrin beta1; Integrin beta3; Laser Coagulation; Male; Mice; Mice, Inbred C57BL; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2007 |
Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1.
Topics: Alendronate; Animals; Bacteroidaceae; Bone Density Conservation Agents; Caspase 1; Clodronic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Interleukin-1beta; Macrophages; Mice; Periodontitis; Toll-Like Receptors | 2009 |
RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro.
Topics: Alendronate; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Clodronic Acid; Cyclin D1; Diphosphonates; In Vitro Techniques; Mice; Microscopy, Electron, Scanning; Myeloid Cell Leukemia Sequence 1 Protein; Osteoclasts; Proto-Oncogene Proteins c-bcl-2; Rabbits; RANK Ligand | 2009 |
Rapid analysis of alkylphosphonate drugs by capillary zone electrophoresis using indirect ultraviolet detection.
Topics: Alendronate; Benzoic Acid; Buffers; Clodronic Acid; Diphosphonates; Electrophoresis, Capillary; Fosfomycin; Hydrogen-Ion Concentration; Organophosphonates; Pharmaceutical Preparations; Phosphoric Acids; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet; Temperature | 2010 |
Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Caspase 1; Cell Line; Clodronic Acid; Interleukin-1; Interleukin-1beta; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Precursors | 2010 |
Fluorimetric quantification of clodronate and alendronate in aqueous samples and in serum.
Topics: Alendronate; Animals; Clodronic Acid; Fluorometry; Kinetics; Limit of Detection; Male; Rats; Rats, Wistar; Reproducibility of Results | 2011 |
Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro.
Topics: Adult; Aged; Alendronate; Biomarkers; Bone Density; Bone Resorption; Cells, Cultured; Clodronic Acid; Diphosphonates; Female; Humans; Imidazoles; Lumbar Vertebrae; Male; Middle Aged; Neurofibromatosis 1; Osteoclasts; Osteoporosis; Zoledronic Acid | 2012 |
Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.
Topics: Alendronate; Animals; Chemotaxis; Clodronic Acid; Diphosphonates; Imidazoles; Interleukin-1alpha; Interleukin-1beta; Leukocytes; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Myeloid Differentiation Factor 88; Neutrophils; Pamidronate; Peritonitis; Receptors, Interleukin-1; Zoledronic Acid | 2012 |
The effect of clodronate on a mevalonate kinase deficiency cellular model.
Topics: Adolescent; Adult; Alendronate; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cells, Cultured; Child; Clodronic Acid; Female; Humans; Inflammation; Lipopolysaccharides; Male; Mevalonate Kinase Deficiency; Mice; Models, Biological; Monocytes; Nitric Oxide; Young Adult | 2012 |
Effects of clodronate and alendronate on osteoclast and osteoblast co-cultures on silk-hydroxyapatite films.
Topics: Alendronate; Animals; Bombyx; Calcium; Clodronic Acid; Coculture Techniques; Diphosphonates; Durapatite; Humans; Osteoblasts; Osteoclasts; Silk; Surface Properties | 2014 |
In vitro effect of bisphosphonates on oral keratinocytes and fibroblasts.
Topics: Alendronate; Bone Density Conservation Agents; Cell Movement; Cell Proliferation; Cells, Cultured; Clodronic Acid; Coculture Techniques; Diphosphonates; Fetus; Fibroblasts; Foreskin; Humans; Imidazoles; Keratinocytes; Male; Mouth Mucosa; Zoledronic Acid | 2014 |
Effect of bisphosphonates on the rapidly growing male murine skeleton.
Topics: Alendronate; Animals; Apoptosis; Biomechanical Phenomena; Bone and Bones; Bone Development; Bone Resorption; Chondrocytes; Clodronic Acid; Diphosphonates; Hypertrophy; Imidazoles; Male; Mice; Mice, Inbred C57BL; Pamidronate; Phenotype; X-Ray Microtomography; Zoledronic Acid | 2014 |
High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis.
Topics: Alendronate; Apoptosis; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Clodronic Acid; Coloring Agents; Diphosphonates; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Humans; Ibandronic Acid; Necrosis; Osteoblasts; Pamidronate; Resting Phase, Cell Cycle; Spectrophotometry; Tetrazolium Salts; Thiazoles; Time Factors | 2015 |
[Bisphosphonate use and related pharmaceutical issues II].
Topics: Administration, Oral; Alendronate; Bone Density Conservation Agents; Bone Neoplasms; Clodronic Acid; Confounding Factors, Epidemiologic; Diphosphonates; Drug Costs; Drug Prescriptions; Drugs, Generic; Humans; Hungary; Ibandronic Acid; Imidazoles; National Health Programs; Osteoporosis; Pamidronate; Retrospective Studies; Risedronic Acid; Zoledronic Acid | 2016 |
The role of monocyte subpopulations in vascular injury following partial and transient depletion.
Topics: Alendronate; Animals; Carotid Artery Injuries; Clodronic Acid; Coronary Restenosis; Liposomes; Male; Monocytes; Rats; Vascular System Injuries | 2018 |
Effects of an oral bisphosphonate and three intravenous bisphosphonates on several cell types in vitro.
Topics: Administration, Oral; Alendronate; Apoptosis; Cell Movement; Cell Survival; Cells, Cultured; Clodronic Acid; Diphosphonates; Endothelial Cells; Fibroblasts; Humans; Ibandronic Acid; In Vitro Techniques; Infusions, Intravenous; Osteoblasts; Zoledronic Acid | 2018 |
Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw.
Topics: Alendronate; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Cell Differentiation; Cell Proliferation; Clodronic Acid; Diphosphonates; Gene Expression; Humans; Imidazoles; Osteoblasts; Osteoclasts; Primary Cell Culture; Transforming Growth Factor beta1; Zoledronic Acid | 2018 |
Microcavity-Supported Lipid Bilayers; Evaluation of Drug-Lipid Membrane Interactions by Electrochemical Impedance and Fluorescence Correlation Spectroscopy.
Topics: Alendronate; Clodronic Acid; Diclofenac; Dielectric Spectroscopy; Electric Impedance; Ibuprofen; Levofloxacin; Lipid Bilayers; Pefloxacin; Rifampin; Spectrometry, Fluorescence | 2019 |