aldosterone has been researched along with spironolactone in 1559 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 717 (45.99) | 18.7374 |
| 1990's | 135 (8.66) | 18.2507 |
| 2000's | 390 (25.02) | 29.6817 |
| 2010's | 279 (17.90) | 24.3611 |
| 2020's | 38 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Haga, N; Kamata, S; Kawabata, T; Kondo, E; Mitsugi, T; Miyata, K; Nagata, W; Nakamura, M; Odaguchi, K; Shimizu, T | 1 |
| Haga, N; Ishibashi, M; Itoh, T; Kamata, S; Matsui, T; Nakamura, M; Odaguchi, K; Shimizu, T; Suzuki, T; Yamada, F | 1 |
| Chinn, LJ; Desai, BN; Salamon, KW | 1 |
| Aumelas, A; Auzou, G; Claire, M; Faraj, H; Grassy, G; Rondot, A | 1 |
| Bao, Y; Kanai, N; Lu, R; Schuster, VL; Wolkoff, AW | 1 |
| Ernst, B; Lill, MA; Vedani, A; Winiger, F | 1 |
| Bellavance, E; Luu-The, V; Poirier, D | 1 |
| Arias, DA; Barbieri, LR; Berrodin, TJ; Bigelis, R; Chang, LP; Luckman, SW; McDonald, LA; Roll, DM; Singh, MP; Yudt, MR | 1 |
| Álvarez de la Rosa, D; Gerona-Navarro, G; González-Muñiz, R; Martín-Martínez, M; Pérez-Gordillo, FL; Rodríguez, Y; Zhou, MM | 1 |
| Kaizu, T; Margolius, HS | 1 |
| Graham, RM; Stokes, GS; Weber, MA | 1 |
| de Wardener, HE; MacGregor, GA; Tasker, PR | 1 |
| Armbruster, H; Beckerhoff, R; Reck, G; Siegenthaler, W; Vetter, W | 1 |
| Handler, JS; Keiser, HR; Zusman, RM | 1 |
| Aupetit, B; Bastien, C; Legrand, JC | 1 |
| Liddle, GW | 2 |
| Wilkins, GE | 1 |
| Gilbert, JC; Lambie, AT; Osore, H | 1 |
| Dowdy, AJ; Ganguly, A; Luetscher, JA; Melada, GA | 2 |
| Arky, RA; Boulter, PR; O'Brian, JT; Saudek, CD; Spark, RF | 1 |
| Rössler, R | 1 |
| Anderson, NS; Fanestil, DD | 1 |
| Feldman, D; Sakauye, C | 1 |
| Lutz, W | 1 |
| Kishikawa, T; Kugai, N; Nishiki, K; Ogata, E | 1 |
| Edelman, IS; Rossier, BC; Wilce, PA | 2 |
| Lafuma, J; Schorn, H; Walter, C | 1 |
| Gregorová, I; Horký, K; Silinková-Málková, E; Tomsová, Z; Vancura, J | 1 |
| Claire, M; Corvol, P; Menard, J; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C | 1 |
| Vetter, H; Vetter, W | 1 |
| Edelman, IS; Warnock, DG | 1 |
| Campbell, GA; Huang, HH; Kledzik, GS; Marshall, S; Meites, J | 1 |
| Aguilera, G; Catt, KJ | 1 |
| Chabert, PR; Guelpa-Decorzant, C; Riondel, AM; Vallotton, MB | 2 |
| Kim, KS; Miyamori, I; Miyamoto, M; Morimoto, S; Takeda, R; Uchida, K | 1 |
| Cutler, GB; Loriaux, DL; Menard, RH; Pita, JC; Rifka, SM; Sauer, MA | 1 |
| Varma, MM | 1 |
| Ferguson, RK; Rovner, DR; Turek, DM | 1 |
| Gunnells, JC; McGuffin, WL | 1 |
| Bartter, FC; Lake, CR; Mitchell, JR; Pool, JL; Rollins, DE; Taylor, AA | 1 |
| Antropova, NV; Ivanova, NA; Vinogradova, LA | 1 |
| Espiner, EA; Mansfield, H; Miles, K | 1 |
| Beckerhoff, R; Furrer, J; Nussberger, J; Siegenthaler, W; Vetter, W | 1 |
| Brunner, HR; Ferguson, RK; Gavras, H; Jaeger, P; Turini, GA | 1 |
| Bekker, VI; Magdich, LV; Svechnikova, NV | 1 |
| Schrijver, G; Weinberger, MH | 1 |
| Craven, D; O'Brien, PM; Selby, C; Symonds, EM | 1 |
| Ibayashi, H; Takasugi, M | 1 |
| Hara, A; Kawai, C; Komuro, T; Matsunaga, M; Ogino, K; Park, C; Saito, N; Yamamoto, J | 1 |
| Abe, K; Chiba, S; Goto, T; Haruyama, T; Hiwatari, M; Imai, Y; Itoh, T; Omata, K; Otsuka, Y; Sakurai, Y; Sato, K; Sato, M; Yasujima, M; Yoshinaga, K | 1 |
| Hofmann, LM; Pedrera, HA; Suleymamov, OD | 1 |
| Dorhout Mees, EJ; Jessurun, RF; Struyvenberg, A | 1 |
| Drozdova, ES | 1 |
| Claire, M; Corvol, P; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C | 1 |
| Al-Dujaili, EA; Huston, GJ | 1 |
| Biglieri, EG; Schambelan, M | 1 |
| Ceresa, F | 1 |
| Gaillard, R; Glasson, P; Riondel, A; Vallotton, MB | 1 |
| Erkkola, R; Lammintausta, R | 1 |
| Albert, JP; Hartmann, F; Jentzen, F; Wronski, R | 1 |
| Corvol, P; Delarue, C; Jegou, S; Kusmierek, MC; Leboulenger, F; Leroux, P; Tonon, MC; Vaillant, R; Vaudry, H | 1 |
| Abe, K; Chiba, S; Imai, Y; Irokawa, N; Sato, M; Yasujima, M; Yoshinaga, K | 1 |
| Falch, DK; Johansson, R; Norman, N; Odegaard, AE | 1 |
| Abe, K; Chiba, S; Irokawa, N; Ito, T; Otsuka, Y; Saito, K; Sakurai, Y; Sato, M; Yasujima, M; Yoshinaga, K | 1 |
| Endo, J; Ikeda, F; Kawano, T; Oseko, F | 1 |
| Casals-Stenzel, J; Losert, W; Schmalbach, J | 1 |
| Bariety, J; Lefkos, N; Marketos, S; Massourides, E; Milliez, P; Papanicolaou, N; Papavassiliou, J | 1 |
| McFarlane, AC | 1 |
| Albano, V; Bellanca, L; Latteri, S; Palazzoadriano, M; Valdes, L | 1 |
| Haferkamp, G; Regli, F | 1 |
| Bauer, JH; Willis, LR | 1 |
| Brass, B; Mertin, J; Simon, O | 1 |
| Alhenc-Gelas, F; Corvol, P; Ducrocq, MB; Menard, J; Plouin, PF | 1 |
| Bucher, H; Furrer, J; Keller, HP; Rampini, S; Zachmann, M | 1 |
| Mueller, A; Steinmetz, PR | 1 |
| Edelman, IS; Law, PY | 1 |
| Cordone, G; Delucchi, M; Fasce, L; Gianfranceschi, P; Iester, A; Torcia, R | 1 |
| Kim, KS; Miyamori, I; Morimoto, S; Takeda, R; Uchida, K; Yamamoto, I | 1 |
| Coleman, TG; Cowley, AW; DeClue, JW; Guyton, AC; McCaa, RE; Norman, RA | 1 |
| Benraad, H; Benraad, T; Drayer, J; Hoefnagels, W; Kloppenborg, P | 1 |
| Brunner, HR; Ferguson, RK; Gavras, H; Jaeger, P; Jéquier, E; Turini, GA | 1 |
| Berl, T; de Torrente, A; Henrich, WL; Katz, FH; Schrier, RW | 1 |
| Hayashida, Y | 1 |
| Aupetit, B; Duchier, J; Legrand, JC | 1 |
| Morris, DJ; Tsai, R | 1 |
| Erbler, HC | 5 |
| Bergman, B; Kågedal, B; Karlberg, BE; Tegler, L; Tolagen, K | 1 |
| Gross, JB; Kokko, JP | 1 |
| Grim, CE; Higgins, JT; Weinberger, MH | 1 |
| Agarwal, MK; Coupry, F; Philippe, M | 1 |
| Benguigui, L; Corvol, P; Houde, M; Menard, J; Milliez, P; Tonnelier, M | 1 |
| Denham, SC; Gunther, RA; Rabinowitz, L | 1 |
| Gussin, RZ | 1 |
| LaCombe, MA | 1 |
| Conn, JW; Hinerman, DL | 1 |
| Beckerhoff, R; Furrer, J; Glänzer, K; Hahn, C; Kolloch, R; Krück, F; Kutz, K; Siegenthaler, W; Vetter, H; Vetter, W; Witassek, F | 1 |
| Esler, M; Zweifler, AJ | 1 |
| Espiner, EA; Hughes, H; Nicholls, MG; Rogers, T | 1 |
| Cheng, SC; Harding, BW; Sadee, W; Suzuki, K | 1 |
| Babický, A; Bartosová, D; Obenberger, J; Stárka, L | 1 |
| Korochkin, IM; Matveeva, IV | 1 |
| Cagini, P; Gueli, U; Lato, M | 1 |
| Bompiani, GD; Donatelli, M; Galluzzo, A; Mangano, MT; Messina, L; Morici, ML; Scaduto, P | 1 |
| Mauser, R; Skrabal, F | 1 |
| Abshagen, U; L'age, M; Oelkers, W; Rennekamp, H; Schöneshöfer, M; Spörl, S | 2 |
| Ellis, C; Hansson, L; Hunyor, SN; Schork, MA; Zweifler, AJ | 1 |
| Rosenthal, J | 1 |
| Chao, J; Kaizu, T; Margolius, HS | 1 |
| Bittar, EE; Tallitsch, RB | 2 |
| Edmonds, CJ | 1 |
| Benraad, TJ; Drayer, JI; Festen, J; Kloppenborg, PW; van't Laar, A | 1 |
| Mertin, J; Schmiedek, P; Simon, O | 2 |
| Baethmann, A; Koczorek, KR | 1 |
| Kuntz, E | 2 |
| Erbler, HC; Hilfenhaus, M | 1 |
| Baethmann, A; Finn, AM; Sadée, W; Schmiedek, P | 1 |
| Bobkova, VI; Kartitskií, VS; Lapkes, TG; Mazurova, SV | 1 |
| Brown, RS; Solomon, RJ | 1 |
| Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P | 1 |
| Kleinman, LI; Loggie, JM; Van Maanen, EF | 1 |
| Ivanova, IA; Markov, KhM | 1 |
| Leumann, EP; Nussberger, J; Vetter, W | 1 |
| Crabbé, J; Desmecht, P; Kolanowski, J | 1 |
| Epstein, M; Levinson, R; Pins, DS; Schneider, N | 1 |
| Wang, GY | 1 |
| Hashimoto, T; Ito, Y; Koshida, H; Miyamori, I; Morimoto, S; Morise, T; Takeda, R; Yamazaki, T | 1 |
| Baulieu, EE; Couette, B; Lombes, M; Rafestin-Oblin, ME | 1 |
| Coupaye-Gerard, B; Ernst, SA; Kleyman, TR | 1 |
| Bader, M; Djavidani, B; Ganten, D; Maser-Gluth, C; Mullins, J; Peters, J; Sander, M; Vecsei, P | 1 |
| Agarwal, MK; Mirshahi, A; Mirshahi, M; Nato, A | 1 |
| Donker, AJ; Hackeng, WH; Meuwissen, SG; van Vliet, AA | 1 |
| de Caro, G; Epstein, AN; Gentili, L; Massi, M; Pompei, P | 1 |
| Bastl, CP; Cragoe, EJ; Schulman, G | 1 |
| Kalish, EE; Logvinenko, NS; Solenov, EI; Svitasheva, NG | 1 |
| Christ, M; Eisen, C; Wehling, M | 1 |
| Brilla, CG; Weber, KT | 1 |
| Hu, SB; Lightman, SL; Tannahill, LA | 1 |
| McClain, JM; Wang, W; Zucker, IH | 1 |
| Levin, RJ; Nzegwu, HC | 1 |
| De Nicola, AF; Grillo, C; McEwen, BS; Piroli, G; Vallee, SM | 1 |
| Barlet-Bas, C; Cheval, L; Couette, B; Doucet, A; Rafestin-Oblin, ME; Viger, A | 1 |
| Morris, DJ; Souness, GW | 1 |
| Broude, NE; Ivanova, LN; Khlebodarova, TM; Logvinenko, NS; Monastyrskaia, GS; Solenov, EI | 1 |
| Fukamizu, A; Gotoh, E; Himeno, H; Hirawa, N; Murakami, K; Noguchi, K; Seo, MS; Shionoiri, H; Ueda, S | 1 |
| Derkx, FH; Donckerwolcke, RA; Griffiven, AW; Schalekamp, MA; Vande Walle, JG; Veenhoven, RH; Wit, JM | 1 |
| Baron, A; Fregly, MJ; Riesselmann, A | 1 |
| Zannad, F | 3 |
| Lewicka, S; Vecsei, P; Weindel, K | 3 |
| Abraham, WT; Dürr, JA; Hensen, J; Schrier, RW | 1 |
| Angeli, P; Caregaro, L; Gatta, A; Menon, F; Merkel, C; Sacerdoti, D | 1 |
| Beier, S; Bittler, D; Elger, W; Laurent, H; Losert, W; Nickisch, K; Nishino, Y; Schillinger, E; Wiechert, R | 1 |
| Carlier, E; Rey, M; Soumireu-Mourat, B; Talmi, M | 1 |
| Saruta, T | 1 |
| Ishikawa, S; Okada, K; Saito, T | 1 |
| Blot-Chabaud, M; Bonvalet, JP; Farman, N | 1 |
| Agarwal, M; Kalimi, M; Opoku, J; Qureshi, D | 1 |
| Bories, P; Duclos, B; Mathieu-Daude, JC; Michel, H | 1 |
| Kairaitis, K; Lumbers, ER | 1 |
| Armanini, D; Pratesi, C; Scali, M; Zampollo, V; Zennaro, MC | 1 |
| Agarwal, MK; Lazar, G; Pagano, M | 1 |
| De Nicola, AF; Grillo, C; McEwen, BS; Vallee, S | 1 |
| Funder, JW; Myles, K; Pearce, PT; Roy, LP | 1 |
| Hasbargen, J; Hensen, J; Schrier, RW; Shapiro, MD | 1 |
| Ichikawa, S; Murata, K; Nakamura, T; Ono, Z; Sakamaki, T; Sakamoto, H; Takayama, Y | 1 |
| Biglieri, EG; Irony, I; Kater, CE; Shackleton, CH | 1 |
| de Jong, W; de Kloet, ER; van den Berg, DT; van Dijken, HH | 1 |
| Fort, CM; Gómez-Sánchez, CE; Gómez-Sánchez, EP | 1 |
| Agarwal, M; Corley, K; Kalimi, M; Opoku, J | 1 |
| Takada, M | 1 |
| Lauler, DP | 1 |
| Helfant, RH | 1 |
| Christiaens, L; Genard, P; Hacha, R; Lomba-Pignon, MR; Palem-Vliers, M | 1 |
| Giebisch, G; Horisberger, JD | 1 |
| Clauss, W; Dürr, JE; Hörnicke, H; Krattenmacher, R; Van Driessche, W | 1 |
| Emadian, SM; Luttge, WG | 1 |
| Alliet, P; Lebenthal, E; Lee, PC; Lu, RB; Madrazo de la Garza, JA; Santer, R | 1 |
| Cragoe, EJ; Kleyman, TR; Kraehenbuhl, JP | 1 |
| Davda, MM; Luttge, WG; Rupp, ME | 1 |
| Jazayeri, A; Meyer, WJ | 1 |
| Cox, M; Feldman, GM; Jorkasky, D | 1 |
| Abe, K; Murakami, O; Omata, K; Sato, M; Takeuchi, K; Yasujima, M; Yoshinaga, K | 1 |
| Katahira, K; Kohara, K; Kumahara, Y; Mikami, H; Ogihara, T; Ohde, H | 1 |
| Davda, MM; Kang, CG; Luttge, WG; Rupp, ME | 1 |
| Binder, HJ; McGlone, F; Sandle, GI | 1 |
| Balfe, JW; DiMartino-Nardi, J; Jose, PA; Martin, K; New, MI; Stoner, E | 1 |
| Agarwal, MK; Kalimi, M | 2 |
| Cato, AC; Weinmann, J | 1 |
| Brody, MJ; Janiak, P | 1 |
| Angeli, M; Moura, AM; Worcel, M | 1 |
| Fanestil, DD | 2 |
| Fregly, MJ; Sumners, C | 1 |
| Ichikawa, S; Kato, T; Kogure, M; Murata, K; Nakamura, T; Sakamaki, T; Sato, K; Tajima, Y | 1 |
| Chen, JH; Hwang, SJ; Lai, YH; Tsai, JH | 1 |
| Capron, MH; Delarue, C; Leboulenger, F; Netchitailo, P; Perroteau, I; Vaudry, H | 2 |
| Alexander, EA; Bengele, HH; Perrone, RD | 1 |
| Kawai, K; Matsuo, K; Tsuchiyama, H; Ueki, Y | 1 |
| Agarwal, MK; Lazar, G | 1 |
| Chekal, MA; Hayslett, JP; Katz, AI; Mujais, SK | 1 |
| Arnhold, IJ; Batista, MC; Bloise, W; Kater, CE; Mendonça, BB; Nicolau, W; Rocha, A | 1 |
| Ito, M; Saito, N; Suzuki, Y | 1 |
| Dietl, P; Oberleithner, H; Silbernagl, S; Weigt, M | 1 |
| Cuppone, R; Emili, M; Ricci, GL | 1 |
| Radó, JP | 1 |
| Arroyo, V; Gaya, J; Jiménez, W; Martínez-Pardo, A; Rivera, F | 1 |
| Ozaki, N; Suzuki, S; Takamura, S; Yoshida, J | 1 |
| Brown, RS; Sugarman, A | 1 |
| Boer, P; Dorhout Mees, EJ; Hené, RJ; Koomans, HA; Rabelink, AJ | 1 |
| Bastl, CP | 1 |
| Dobrović-Jenik, D; Milković, S; Ozegović, B | 1 |
| Capek, K; Pácha, J; Popp, M | 2 |
| Adam, WR; Adams, BA; Ellis, AG | 1 |
| O'Brien, PM; Vellacott, ID | 1 |
| Birbari, AE; Daouk, MM; Mukaddam-Daher, S | 1 |
| Funyu, T; Igarashi, R; Kawaguchi, T; Nigawara, K; Suzuki, T; Terayama, Y; Toda, T; Yamaya, K; Yanagiya, H | 1 |
| Binder, HJ; Boulpaep, EL; Budinger, ME; Halevy, J; Hayslett, JP | 1 |
| Aupetit, B; Blanchouin-Emeric, N; Defaye, G; Toury, R; Vonarx, V | 1 |
| DiMartino-Nardi, J; New, MI; Stoner, E | 1 |
| Boer, P; Dorhout Mees, EJ; Hené, RJ; Koomans, HA | 1 |
| Epstein, AN; Nicolaïdis, S; Sakai, RR | 1 |
| Akiya, T; Katayama, T; Kawamata, S; Koike, H; Nakada, T; Shigematsu, H; Takaya, K | 1 |
| Clauss, W; Dürr, JE; Guth, D; Skadhauge, E | 1 |
| Bentley, PJ; Grubb, BR | 1 |
| Akbar, FA; Pearce, MY; Shroff, NE; Stratford, ME; Vellacott, ID | 1 |
| Djiane, J; Houdebine, LM; Jahn, GA; Moguilewsky, M | 1 |
| De Nicola, AF; Lambdin, LT; McEwen, BS; Rainbow, TC | 1 |
| Funder, JW; Gannell, JE; Quirk, SJ | 1 |
| Fujita, T; Fukase, M; Kinoshita, Y; Miyauchi, A; Nakada, M; Takenaka, M | 1 |
| Douglas, JG | 1 |
| Greminger, P; Groth, H; Stimpel, M; Vetter, H; Vetter, W | 1 |
| Drury, PL | 1 |
| Garcia-Alves, M; Macieira-Coelho, E; Reis-Valle, A | 1 |
| Bertagna, C; Corvol, P; Husson, JM; Le Go, A; Menard, J; Sassano, P; Tache, A; Ulmann, A | 1 |
| Gomez-Sanchez, EP | 1 |
| Bernardi, M; Gasbarrini, G; Rusticali, AG; Servadei, D; Trevisani, F | 1 |
| Gibson, TP; O'Brien, MS; Salamone, LF | 1 |
| Boucher, RC; Gatzy, JT; Knowles, MR | 1 |
| Buse, M; Casals-Stenzel, J; Losert, W | 1 |
| Beaumont, K | 1 |
| Brown, JJ; Ferriss, JB; Fraser, R; Kay, AW; Lever, AF; Neville, AM; O'Muircheartaigh, IG; Robertson, JI; Symington, T | 1 |
| Brown, JJ; Ferriss, JB; Fraser, R; Lever, AF; Love, DR; Robertson, JI; Wilson, A | 1 |
| de Klerk, JN; Schoonees, R | 1 |
| Backmund, H; Koczorek, KR; Mertin, J | 1 |
| Bradshaw, SD; Nagy, KA; Shoemaker, VH | 1 |
| Richards, P | 1 |
| Shields, R | 1 |
| Benjamin, WB; Singer, I | 1 |
| Abbott, EC; Gornall, AG; Laidlaw, JC; Stiefel, M; Sutherland, DJ | 1 |
| Henane, R; Laurent, F | 1 |
| Melby, JC | 2 |
| Hoffmeister, AW; Hoffmeister, W | 1 |
| Mattern, HR; Schaumann, W | 1 |
| Erbler, H | 1 |
| Besarab, A; Charney, AN; Epstein, FH; Silva, P | 1 |
| Fachet, J; Hajtman, B; Palkovits, M; Stark, E | 1 |
| Arboit, JM; Greenberg, AJ; New, MI; Worthen, HG | 1 |
| Weille, FL | 1 |
| Avenhaus, H; Koczorek, KR | 1 |
| Mundi, B; Nuding, J; Perner, F; Vallent, K | 1 |
| Brackett, NC; Koppel, M; Nixon, WP; Randall, RE | 1 |
| Führ, J; Lurati, M; Mertens, HG | 1 |
| Palkovits, M | 1 |
| Dale, SL; Kahn, PC; Melby, JC; Spark, RF | 1 |
| Allner, R; Dürr, F; Held, H; Kaufmann, W; Meurer, KA; Nieth, H; Schürholz, J; Steiner, B; Streicher, E | 1 |
| Blanton, JH; Coker, AS; Hardin, JG | 1 |
| Hori, S; Masumura, S; Ono, K | 1 |
| Hori, S; Masumura, S; Ono, K; Sato, Y | 1 |
| Goodman, AD; Hartroft, PM; Vagnucci, AH | 1 |
| Crout, JR; Jose, A; Kaplan, NM | 1 |
| Bodin, G; Gillot, F; Rival, JM | 1 |
| Duffy, PA; Frawley, TF; Gonzalez, Y; McGiff, JC; Muzzarelli, RE; Pierce, CE | 1 |
| Brown, JJ; Cost, WS; Desmit, EM; Fraser, R; Lever, AF; Robertson, JI | 1 |
| Arant, BS; Brackett, NC; Still, WJ; Young, RB | 1 |
| Essing, HG; Jörgensen, A; Schaller, KH; Szadkowski, D | 1 |
| Dale, SL; Melby, JC; Wilson, TE | 1 |
| Bartter, FC; Delea, CS; Simopoulos, AP | 1 |
| Muller, AF; Scholer, D; Vallotton, MB | 1 |
| Altamura, B; Chiantera, A; De Salvia, F; L'Abbate, N; Lostorto, A; Musti, M | 1 |
| Mendlowitz, M; Naftchi, NE | 1 |
| Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Haywood, E; Lever, AF; Robertson, JI | 1 |
| Spark, RF | 1 |
| Biglieri, EG; Giebink, GS; Gotlin, RW; Katz, FH | 1 |
| Bartter, FC; Golde, DW; Roth, JA; Simopoulos, AP | 1 |
| Forte, LR | 1 |
| Fukuchi, S; Nakajima, K; Takenouchi, T | 1 |
| Gantt, C; Grossman, A; Ramanathan, K | 1 |
| Gabrilove, JL; Krakoff, LR; Modlinger, RS; Nicolis, GL | 1 |
| Laidlaw, JC | 1 |
| Horton, R | 1 |
| Endo, J; Kawaguchi, Y; Kono, T; Sakai, T; Yoshimi, T | 1 |
| Edelman, IS; Feldman, D; Funder, JW; Marver, D; Stewart, J | 1 |
| Fichman, MP; Horton, R; Michelakis, AM | 1 |
| Edelman, IS; Feldman, D; Funder, JW; Highland, E | 1 |
| Genard, P; Matagne, D; Palem-Vliers, M; Reuter, A | 1 |
| Momose, G; Nakada, T; Shigematsu, H; Tateno, Y; Yoshida, T | 1 |
| Aakvaag, A; Jorgensen, H; Marton, P; Sundsfjord, JA | 1 |
| Speller, PJ; Streeten, DH | 2 |
| Alberti, GM; Limal, JM; Postel-Vinay, MC; Rappaport, R; Ricour, C; Royer, P | 1 |
| Greengard, P; Liu, AY | 1 |
| Leaf, A; Sharp, GW | 2 |
| Kirsten, E; Kirsten, R | 1 |
| Ilett, KF; Lockett, MF | 1 |
| Carey, RM; Hook, EW; Wooster, LD | 1 |
| Alexander, RW; Geller, RG; Gill, JR; Horwitz, D; Keiser, HR; Margolius, HS; Pisano, JJ | 1 |
| Horwitz, D; Keiser, HR; Margolius, HS; Pisano, JJ | 1 |
| Fukuchi, S; Nakajima, K; Nishisato, K; Takenouchi, T | 1 |
| Berthoux, F; Blanc, N; Colon, S; Leitienne, P; Pozet, N; Sassard, J; Touraine, JL; Traeger, J; Zech, P | 1 |
| Kosman, ME | 1 |
| Armanini, D; Mantero, F; Urbani, S | 1 |
| Rorive, GL | 1 |
| Baethmann, A; Brendel, W; Kiffner, E; Stass, P | 1 |
| Hodler, J | 1 |
| Jones, J | 1 |
| Donohue, JP; Weinberger, MH | 1 |
| Conn, HO | 1 |
| Kirdani, RY; Murphy, GP; Sampson, D; Sandberg, AA | 1 |
| Douglas, JG; Hollifield, JW; Liddle, GW | 1 |
| Klaus, D; Klumpp, F; Zehner, J | 1 |
| Beevers, DG; Brown, JJ; Ferriss, JB; Fraser, R; Lever, AF; Robertson, JI | 1 |
| Ripa, R | 1 |
| François, B | 1 |
| Distler, A | 1 |
| Shimizu, N | 1 |
| Mills, IH | 1 |
| Ackerman, NB; Johnson-Giannopoulos, N; Winer, N | 1 |
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| Baulon, A; Fournier, A; Kazandjian, M; Lagrue, G; Legrand, JC; Menard, J; Nakache, JP; Salmon, D | 2 |
| Regal, EM; Schrier, RW | 1 |
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| Begemann, H; Mertin, J; Theml, H; Winnewisser, M | 1 |
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| Correa, RJ; Gibbons, RP; Tremann, JA | 1 |
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| Corvol, P; Ménard, J; Milliez, P | 1 |
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| Knorr, D; Solc, J | 1 |
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| Bolte, HD; Lüderitz, B | 1 |
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| Kaplan, NM | 2 |
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| Kiseleva, ZM; Kuz'mina, AE; Sycheva, IM; Vinogradov, AV | 1 |
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| Esch, I | 1 |
| Baethmann, A; Brendel, W; Koczorek, KR; Land, W; Stass, P | 1 |
| Baethmann, A; Brendel, W; Kiffner, E; Land, W; Stass, P | 1 |
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| Dévényi, I; Marosi, J; Radó, JP; Takó, J | 1 |
| Ogawa, E; Shibata, K; Suzuki, S | 1 |
| Garcia, HA; Hofmann, LM; Krupnick, MI | 1 |
| Borwn, JJ; Ferriss, JB; Fraser, R; Lever, AF; Robertson, JI | 1 |
| Bartter, FC; Cox, J; Delea, CS; Gill, JR | 1 |
| Crane, MG; Harris, JJ; Johns, VJ | 1 |
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| Hilmer, W | 1 |
| Chew, MM; Elliott, AB | 1 |
| Porter, GA | 2 |
| Sirs, JA | 1 |
| Hüsten, J; Ruiz-Torres, A | 1 |
| Melby, JC; Spark, RF | 3 |
| Karppanen, H; Vapaatalo, H | 1 |
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| Fischer, G; Guibert, B; Imbert, D; Mansuy, L; Ravon, R | 1 |
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| Gibiński, K; Giec, L; Kokot, F; Nowak, S | 3 |
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| Brown, JJ; Chinn, RH; Dusterdieck, G; Fraser, R; Lever, AF; Robertson, JI; Tree, M | 1 |
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| Crabbé, J | 3 |
| Favrod-Coune, CA; Gaillard, RC; Muller, AF; Riondel, AM; Vallotton, MB | 1 |
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| Delarue, C; Deraedt, R; Leboulenger, F; Netchitailo, P; Perroteau, I; Philibert, D; Vaudry, H | 1 |
| Gatkowska, J; Genest, J; Julesz, J; Lis, M; Mizsei, I | 1 |
| Favre, L; Glasson, P; Riondel, A; Vallotton, MB | 1 |
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| Cammarata, PS; Fretland, DJ | 1 |
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| Bönner, G; Helber, A; Hummerich, W; Kaufmann, W; Konrads, A; Meurer, KA; Wambach, G | 1 |
| Cocco, F; Dessì-Fulgheri, P; Fiori, C; Glorioso, N; Leoni, C; Madeddu, P; Rappelli, A; Sanna, G | 1 |
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| Glasson, P; Vallotton, MB | 1 |
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| Fraser, R; Hettiarachchi, J; Morton, JJ; Ramsay, LE | 1 |
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| Magariños, AM; McEwen, BS; Pavlides, C; Watanabe, Y | 1 |
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| Clauss, W; Hoffmann, B; Krattenmacher, R; Van Driessche, W | 1 |
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| Han, YL; Hu, XL; Jing, QM; Liu, JQ; Tong, M | 1 |
| de Jong, W; de Kloet, ER; Van den Berg, DT | 1 |
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| Dubbelman, R; Kröger, R; Ten Bokkel-Huinink, WW; Van Vliet, AA | 1 |
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| Bhathena, SJ; Canary, JJ; Gannon, CA; Glen, ML; Kennedy, BW; Smith, PM; Werman, MJ | 1 |
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| Colussi, G; De Ferrari, ME; Macaluso, M; Minetti, L; Rombolà, G | 1 |
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| Davies, DL; Forrest, G; McInnes, GT; Murdoch, DL | 1 |
| Aramaki, T; Katsuta, Y; Okumura K [corrected to Okumura, H]; Okumura, H; Satomura, K; Sekiyama, T | 1 |
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| Pitt, D | 1 |
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| Funder, JW; Liu, JP; Sato, A | 1 |
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| Burton, G; Galigniana, MD; Lantos, CP; Monteserín, MC; Veleiro, AS; Vicent, GP | 1 |
| Fejes-Tóth, G; Náray-Fejes-Tóth, A; Pearce, D | 1 |
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| Fromm, M; Grotjohann, I; Schulzke, JD | 1 |
| Christ, M; Falkenstein, E; Günther, A; Heck, M; Schmidt, BM; Wehling, M | 1 |
| Hong, JH; Hur, GM; Jeon, JR; Lee, JH; Seok, JH; Sung, JY | 1 |
| Saruta, T; Sato, A; Suzuki, Y | 1 |
| Geibel, JP; Harvey, BJ; O'Sullivan, GC; Schneider, MF; Winter, DC | 1 |
| Bravo, EL; Ghose, RP; Hall, PM | 1 |
| Weber, KT | 2 |
| Nicholls, MG; Richards, AM | 1 |
| Amemiya, M; Asano, Y; Ebata, S; Muto, S; Nemoto, J; Okada, K; Saito, T | 1 |
| Grafte-Faure, S; Leveque, C; Norris, V; Soria, C; Vannier, JP; Vasse, M | 1 |
| King, SR; Smeda, J; Vasdev, S | 1 |
| Jung, RT; Lim, PO; MacDonald, TM | 1 |
| Chen, Q; Liu, D; Zheng, C | 1 |
| Ferriss, JB | 1 |
| Fluharty, SJ; Ma, LY; McEwen, BS; Sakai, RR | 1 |
| Harvey, BJ; Higgins, M | 1 |
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| Haas, T; Hilgertová, J; Prázný, M; Sindelka, G; Skrha, J; Widimský, J | 1 |
| Agarwal, MK; Golestaneh, N; Mirshahi, M; Valamanesh, F | 1 |
| Liu, YJ; Nakagawa, Y; Nakanishi, T; Ohzeki, T; Saegusa, H; Toya, K; Wang, Y | 1 |
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| Puddefoot, JR; Vinson, GP; Xiao, F | 1 |
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| Burton, G; Galigniana, MD; Lantos, CP; Piwien-Pilipuk, G; Vicent, GP | 1 |
| Brilla, CG | 1 |
| Cluzeaud, F; Le Menuet, D; Lombès, M; Penfornis, P; Viengchareun, S; Zennaro, MC | 1 |
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| Soberman, JE; Weber, KT | 1 |
| Cha, AJ; Judge, KW; Malecha, SE | 1 |
| Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH | 1 |
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| Pitt, B; Rajagopalan, S | 1 |
| Bloem, LJ; Chun, TY; Pratt, JH | 1 |
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| Bauer, JA; Ghosh, S; Holycross, BJ; Kambara, A; Kwiatkowski, P; McCune, SA; Schanbacher, B; Wung, P | 1 |
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| Neves, MF; Pu, Q; Schiffrin, EL; Touyz, RM; Virdis, A | 1 |
| Blomme, EA; Bond, BR; Funder, JW; Goellner, JJ; McMahon, EG; Qin, W; Rocha, R; Rudolph, AE | 1 |
| Carr, AA; Jordan, R; Krause, S; Oigman, W; Roniker, B; White, WB | 1 |
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| Christ, M; Falkenstein, E; Feuring, M; Hafner, M; Kellner, M; Lösel, R; Peiter, A; Wehling, M | 1 |
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| HERTZ, R; TULLNER, WW | 1 |
| BEAUREGARD, P; BOLTE, E; BROUILLET, J; GENEST, J; MARC-AURELE, J; VERDY, M | 1 |
| CARBONE, JV; DOOLAN, PD; HUTCHIN, ME; WIGGINS, RA | 1 |
| BAILEY, RE | 1 |
| CALLAY, R; COUDOUX, P; MATHIS, P | 1 |
| CEJKA, V; de VRIES, L; MERKELBACH, JW | 1 |
| BARTHES, J; ETIENNE-MARTIN, P; GUERRIN, A; KLEPPING, C | 1 |
| ETIENNE-MARTIN, P; GUERRIN, J; KLEPPING, C | 1 |
| FLANDRIN, P; GROULADE, J; HOLLARD, D; RACHAIL, M | 1 |
| DUSTAN, H; GEORGOPOULOS, AJ; PAGE, IH | 1 |
| BEL, A; BOTHIER, F; GIRARD, M; GUILLERMET, J; MICHEL, J | 1 |
| GOTTLIEB, B; LAURENT, LP | 1 |
| HILD, R; KRUECK, F | 2 |
| FARMER, TA; HILL, R; HOOD, WG; PITTMAN, JA | 1 |
| CESANA, A; D'AMICO, G | 1 |
| DE VLEESCHHOUWER, GR | 1 |
| BEN-ZENOU, A; DOURY, P; DULAC, JF; OUGIER, J; WEIL, B | 1 |
| BONCOMPAIN, J; EMIN, R; MULLER, B | 1 |
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| NORTH, JD; SAYERS, EG; SIMS, FH | 1 |
| OGDEN, DA; RUBIN, AL; SCHERR, L; SPRITZ, N | 1 |
| NISSEN, NI; OSTERGAARD KRISTENSEN, HP | 1 |
| KERR, DN; POSKANZER, DC | 1 |
| ROMANI, JD | 1 |
| BLOCH, R; SCHWARTZ, J | 1 |
| KAGAWA, CM | 2 |
| LABADIE, P | 1 |
| BRETTE, R; FRANCOIS, B; LEVRAT, M; MESTRALLET, G; TISSOT, A | 1 |
| LOCKWOOD, CH | 1 |
| BEHRLE, FC; MANNING, RT | 1 |
| MESSINA, B | 1 |
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| EVREUX, P; JOUD, R; POULET, R; ROULLET, A; SALLE, B; TOLOT, F | 1 |
| TRAEGER, J | 1 |
| BERMAN, LB; TUBLIN, IN | 1 |
| ARCADIO, F; BESSET, C; JOUD, R; VACHON, A | 1 |
| VESIN, P | 2 |
| DUCOMMUN, P; ENGEL, E; MULLER, AF; VEYRAT, R | 2 |
| FATH, A; VIALA, JJ | 1 |
| WAY, JL | 1 |
| BONNEFOY, S; JEUNE, M; PUGEAUT, R; SALLE, B | 1 |
| CREMER, G; ETIENNE, JP; JUSTIN-BESANCON, L; LAROCHE, C; NENNA, A | 2 |
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| BORST, JG; CEJKA, V; de VRIES, L; MAJOOR, CL; van DAATSELAAR, J | 1 |
| EILERSEN, P; HEMPEL-JORGENSEN, P | 1 |
| FARRELLY, RO; HOWIE, RN; NORTH, JD | 1 |
| MALVIN, RL; VANDER, AJ; WILDE, WS | 1 |
| GARCIA, H; GAZMURI, R; KATZ, E; KATZ, R; VELASCO, M | 1 |
| ALBAHARY, C; POMMEY, B | 1 |
| BAJUSZ, E; JASMIN, G | 1 |
| BAUER, G; RIECKMANN, P; SCHAUMANN, W | 1 |
| BONINI, A | 1 |
| BRECHT, W; SCHNEIDER, H | 1 |
| COSTA, R | 1 |
| CRANSTON, WI; JUEL-JENSEN, BE | 1 |
| CASTELLUCCIO, A; D'AMICO, G | 1 |
| COPPAGE, WS; DAVIDSON, ET; ISLAND, D; LIDDLE, GW | 1 |
| LE POOLE, A; SCHOPMAN, W; VAANDRAGER, H; van DOMMELEN, C; WADMAN, SK | 1 |
| DRILL, VA | 1 |
| FALENCIK-EDELWEJN, M | 1 |
| DELAUDE, A; GADRAT, J; JORDA, MF; MOREAU, G | 1 |
| GANTT, CL | 1 |
| BRILLANTE, C; GARAGNANI, A; SURIANI, L | 1 |
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| COMOLI, G; GHIRINGHELLI, L | 1 |
| GANTT, CL; GOCHMAN, N | 1 |
| GRAZIANI, G; MOLE, R | 1 |
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| STARK, G | 1 |
| PREIS, H; STRATA, A | 1 |
| TANZ, RD | 1 |
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| GAZMURI, R; KATZ, R; VELASCO, M | 1 |
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| BEER, G; FURMAN, KI | 1 |
| ECKLUND, RE; GANTT, CL | 1 |
| FALET, R; FAVAREL-GARRIGUES, JC; HOUDAS, Y | 1 |
| BIGLIERI, EG; HORTON, R | 1 |
| ROSS, EJ | 1 |
| STEINMAN, AM | 1 |
| MULLER, AF; SIEGENTHALER, P; VEYRAT, R | 1 |
| WIATZMAN, MB | 1 |
| ALBEAUX-FERNET, M; BELLOT, L; CHABOT, J; DERIBREUX, J; GELINET, M; ROMANI, JD | 1 |
| ANDRIEU, J; ISORNI, P; PEYRIDIEUX, R | 1 |
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| DAVIDSON, ET; DEVENUTO, F; WESTPHAL, U | 2 |
| DE MARTINIS, C; MENSA, R; PUPITA, F | 1 |
| CHAGOYA, L; LANDA, L; RIVERA, A; SEPULVEDA, B | 1 |
| BLASI, A; CONDORELLI, M; FRANCAVIGLIA, A; GAGLIO, M; MAZZONE, O; MODICA, G; RAGUSA, G; SMILARI, L; TAMBURINO, G; ZINNARI, A | 1 |
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| CARRUTHERS, BM; LEDRAY, RD; MCINTOSH, HW; SERAGLIA, M; WALSH, GC | 1 |
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| MELBY, JC; SANDERS, LL | 1 |
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| BROWN, JJ; DAVIES, DL; LEVER, AF; ROBERTSON, JI | 1 |
| BIRD, CE; GORNALL, AG; LAIDLAW, JC; YENDT, ER | 1 |
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| AMERIO, A; GENTILELAROSA, C; LEONDEFF, I; MATARAZZO, C | 1 |
| ANIBALDI, A; BOSCHERINI, B; PATANE, E; PEDULLA, T | 1 |
| ARMASCRUZ, R; GOMEZ, R; MARDONES, J; PLAZADELOSREYES, M | 1 |
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| CHRISTIAANS, AP; SCHMIDT, AL | 1 |
| BIGLIERI, EG; SLATON, PE | 1 |
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| BROWN, EA; KRAYCHY, S; MIZUBA, S; MUIR, RD; NICHOLSON, RT; TWEIT, RC | 1 |
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| FUJITA, T; MATSUZAKI, F; MORII, H; MOTOHASHI, K; MURAKAWA, S; OHSAWA, N; OKINAKA, S; SHIZUME, K; UCHIKAWA, T | 1 |
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| Albermann, L; Hillebrand, U; Ludwig, T; Oberleithner, H; Riethmüller, C; Schäfer, C; Schillers, H; Shahin, V | 1 |
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| Adler, GK; Alvarez de la Rosa, D; El Mogrhabi, S; Fallo, F; Feraco, A; Jaisser, F; Nguyen Dinh Cat, A; Quilliot, D; Rossignol, P; Sierra-Ramos, C; Touyz, RM; Urbanet, R; Venteclef, N | 1 |
| Bruder-Nascimento, T; Cau, SB; Lopes, RA; Manzato, CP; Mestriner, FL; Montezano, AC; Neves, KB; Nguyen Dinh Cat, A; Silva, MA; Tostes, RC; Touyz, RM | 1 |
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| Korantzopoulos, P; Letsas, KP; Li, G; Liu, T; Shao, Q; Zhang, Z | 1 |
| Anzai, K; Kawate, H; Matsuda, Y; Matsuzaki, C; Nomura, M; Ohnaka, K; Sakamoto, R; Shibue, K; Takayanagi, R | 1 |
| Alía, M; Ballesteros, S; Cannata-Ortiz, P; Cortegano, I; de Andrés, B; de Las Heras, N; Egido, J; Gaspar, ML; Lahera, V; Martín-Fernández, B; Moreno, JA; Olivares-Álvaro, E; Rubio-Navarro, A | 1 |
| Bomback, AS | 1 |
| Bian, Z; Chen, P; Gu, H; Guo, L; Hu, C; Pan, Y; Zhang, Y; Zhu, S | 1 |
| Calhoun, DA; Dudenbostel, T; Ghazi, L; Lin, CP; Oparil, S | 1 |
| Duprez, DA; Epstein, M | 1 |
| Ding, Q; Feldman, RD; Gros, R; Hussain, Y; Limbird, LE; Pickering, JG | 1 |
| Armanini, D; Calò, LA; Sabbadin, C | 1 |
| Chrissobolis, S; Dinh, QN; Drummond, GR; Evans, MA; Sobey, CG; Young, MJ | 1 |
| Yang, J; Young, MJ | 1 |
| Bleich, M; de Bruijn, PI; Jensen, IS; Larsen, CK; Leipziger, J; Praetorius, HA; Sorensen, MV | 1 |
| Buschmeyer, B; Koehncke, C; Lisewski, U; Pieske, B; Roepke, TK; Wilck, N | 1 |
| Liu, ZK; Lu, XY; Luo, ZF; Xiao, HB | 1 |
| Amancio, Gde C; Araujo, CM; de Assis, LV; Hermidorff, MM; Isoldi, MC; Lemos, Dda S; Silva, ME | 1 |
| Amar, L; Baguet, JP; Bardet, S; Chabre, O; Chaffanjon, P; Chamontin, B; Douillard, C; Durieux, P; Girerd, X; Gosse, P; Hernigou, A; Herpin, D; Houillier, P; Jeunemaitre, X; Joffre, F; Kraimps, JL; Lefebvre, H; Ménégaux, F; Mounier-Véhier, C; Nussberger, J; Pagny, JY; Pechère, A; Plouin, PF; Reznik, Y; Steichen, O; Tabarin, A; Zennaro, MC; Zinzindohoue, F | 1 |
| Kang, SH; Kim, I; Kim, M; Lee, E; Lee, HA | 1 |
| Belyavskiy, E; Brandenburg, VM; Brussee, H; Catena, C; Fahrleitner-Pammer, A; Gaksch, M; Grübler, MR; März, W; Meinitzer, A; Perl, S; Pieske, B; Pilz, S; Scharnagl, H; Sechi, LA; Tomaschitz, A; Van Ballegooijen, AJ; Verheyen, N; Wetzel, J | 1 |
| Enomoto, D; Higaki, J; Kukida, M; Miyoshi, K; Nagao, T; Okamura, H; Okura, T; Pei, Z; Tanino, A | 1 |
| Fang, H; Lu, A; Sun, P; Wang, H; Xu, C; Yang, T; Zhou, L | 1 |
| Jolly, A; Miquel, P; Shrier, A; Touyz, RM; Valinsky, WC | 1 |
| An, Y; Guo, A; Li, Y; Liu, T; Wang, M; Wang, Y; Zhang, G; Zhang, Y; Zhou, K | 1 |
| Campos, DHS; Cezar, MDM; Cicogna, AC; Costa, LCO; Damatto, RL; Iyomasa, RM; Martinez, PF; Minicucci, MF; Okoshi, K; Okoshi, MP; Silva, MB | 1 |
| Adachi, S; Baker, ME; Katsu, Y; Oka, K; Sato, R; Sugimoto, A | 1 |
| Bornstein, SR; Brown, NF; Brunssen, C; Deussen, A; Eisenhofer, G; Engelmann, F; Hofmann, A; Huber, J; Jannasch, A; Martin, M; Mittag, J; Morawietz, H; Peitzsch, M; Streicher, R; Weldon, SM | 1 |
| Asbach, E; Bidlingmaier, M; Fourkiotis, V; Gerum, S; Lichtenauer, UD; Manolopoulou, J; Quinkler, M; Reincke, M | 1 |
| Deinum, J; Kramers, BJ; Kramers, C; Lenders, JW | 1 |
| Adler, GK; Baudrand, R; Ferri, C; Garza, AE; Gupta, N; Hopkins, PN; Jeunemaitre, X; Leopold, JA; Loscalzo, J; Pojoga, LH; Romero, JR; Vaidya, A; Williams, GH; Williams, J | 1 |
| Dhople, VM; Felix, SB; Gross, S; Hammer, E; Könemann, S; Samal, R; Völker, U; Wenzel, K | 1 |
| Hilgers, KF; Schneider, MP | 1 |
| Fan, Y; Hu, B; Jia, R; Lu, B; Luo, X; Qiao, H; Sun, B; Wang, N; Yan, J; Zhou, H | 1 |
| Alzoubi, KH; Bonyan, R; Mayyas, F | 1 |
| Channar, PA; El-Seedi, H; Faisal, M; Larik, FA; Mehfooz, H; Saeed, A; Shahzad, D | 1 |
| Bar-Nur, D; Jaber, BL | 1 |
| Cavalcanti, AH; Cortez, AF; de Souza, F; Margallo, V; Muxfeldt, ES; Salles, GF | 1 |
| Bistrup, C; Hansen, MR; Hansen, PB; Hinrichs, GR; Jacobsen, IA; Jensen, BL; Kurt, B; Oxlund, C; Schwarzensteiner, I; Stæhr, M; Svenningsen, P; Thuesen, AD; Toft, A | 1 |
| Gong, Q; Liu, QH; Sun, XH; Yuan, ST | 1 |
| Collier, TJ; Girerd, N; Lamiral, Z; Machu, JL; McMurray, JJV; Olivier, A; Pitt, B; Pizard, A; Pocock, SJ; Rossignol, P; Swedberg, K; van Veldhuisen, DJ; Zannad, F | 1 |
| He, JQ; Liang, LJ; Liu, BB; Ma, XL; Shimosawa, T; Wang, CH; Wang, XT; Wang, Z; Xu, QY | 1 |
| Chadwick, JA; Gomez-Sanchez, CE; Gomez-Sanchez, EP; Hauck, JS; Rafael-Fortney, JA | 1 |
| González-Ramírez, R; Molina-Jijón, E; Namorado-Tónix, C; Pedraza-Chaverri, J; Reyes, JL; Rodríguez-Muñoz, R | 1 |
| Alesutan, I; Borst, O; Castor, T; Feger, M; Gawaz, M; Kratschmar, DV; Kuro-O, M; Lang, F; Leibrock, C; Mia, S; Odermatt, A; Pieske, B; Pilz, S; Sacherer, M; Tomaschitz, A; Viereck, R; Voelkl, J; Wagner, CA | 1 |
| Donderski, R; Grajewska, M; Manitius, J; Miśkowiec, I; Odrowąż-Sypniewska, G; Siódmiak, J; Stefańska, A; Stróżecki, P; Sulikowska, B | 1 |
| Andrukhova, O; Baierl, A; Becirovic, A; Erben, RG; Ford, K; Handschuh, S; Katica, N; Modert, M; Slavic, S; Zeitz, U | 1 |
| Gong, H; Li, H; Lu, Y; Ma, X; Wang, B; Wang, C; Wu, Z; Yan, Y; Zhang, X | 1 |
| Agrawal, N; DeCarlo, KE | 1 |
| Chen, YP; Cheng, H; Dong, HR; Dong, J; Liu, BL; Rui, HL; Yang, M; Zhu, JJ | 1 |
| Athyros, VG; Doumas, M; Imprialos, KP; Karagiannis, A; Stavropoulos, K | 1 |
| Huke, S | 1 |
| Aagaard, A; Bamberg, K; Björnson Granqvist, A; Edman, K; Geschwindner, S; Granberg, KL; Gunnarsson, A; Hartleib-Geschwindner, J; Huang, Y; Jaisser, F; Jansson-Löfmark, R; Johansson, U; Myhre, S; William-Olsson, L | 1 |
| Brown, MJ; Caulfield, MJ; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, IS; McInnes, GT; Morant, SV; Padmanabhan, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B | 1 |
| Calhoun, DA | 1 |
| Andersen, MS; Buhl, LF; Glintborg, D; Pedersen, FN | 1 |
| Aberer, F; Alesutan, I; Bachmann, A; Catena, C; Grübler, MR; März, W; Meinitzer, A; Obermayer-Pietsch, B; Pandis, M; Pilz, S; Schwetz, V; Sechi, LA; Tomaschitz, A; Trummer, C; Verheyen, N; Voelkl, J | 1 |
| Cooper, LB; Hernandez, AF | 1 |
| Aleksiejczuk, M; Chabielska, E; Gromotowicz-Poplawska, A; Marcinczyk, N; Mikita, J; Stankiewicz, A; Szemraj, J | 1 |
| Anderson, AH; Charytan, DM; Dember, LM; DiCarli, M; Himmelfarb, J; Hsu, JY; Hung, AM; Ikizler, TA; Kimmel, PL; Kliger, AS; Landis, JR; Mehrotra, R; Raj, DS; Sharma, S; Skali, H; Weiner, DE; Williams, M | 1 |
| Hagiya, H; Naito, T; Nakagami, F; Yamamoto, K | 1 |
| Dong, D; Fan, TT; Ji, YS; Wu, S; Yu, JY; Zhang, L | 1 |
| Manolis, AA; Manolis, AS; Manolis, TA; Melita, H | 1 |
| Khannanova, Z; Li, Y; Li, YY; Liu, GZ; Liu, YW; Yuan, Y; Zhang, JW; Zhang, S; Zhang, Y; Zhao, XB | 1 |
| Huang, X; Lan, Q; Liang, K; Ou, X | 1 |
| Casarini, DE; Sanches Aragão, D; Stoll, D; Yokota, R | 1 |
| Alexandre, J; Allouche, S; Beygui, F; Buklas, D; Chequel, M; Cholley, B; Dolladille, C; Fellahi, JL; Fischer, MO; Legallois, D; Milliez, P; Ollitrault, P; Parienti, JJ; Rozec, B; Saplacan, V | 1 |
| Battaglia, G; Fiorini, F; Granata, A; La Rosa, S; Maccarrone, R; Ocello, A; Randone, S | 1 |
| Fuller, PJ; He, S; Jin, R; Martín-Fernández, B; Smith, BJ; Yao, YZ; Young, MJ | 1 |
| Bíró, T; Farman, N; Funk, W; Hundt, JE; Langan, EA; Paus, R; Sass, S | 1 |
| Abalı, S; Bereket, A; Canpolat, N; Guran, T; Kucuk, N; Turan, S; Yavas Abalı, Z; Yesil, G | 1 |
| Gao, X; Li, J; Li, Q; Lu, G; Xiao, Y; Xie, D; Zhai, Y; Zhang, J | 1 |
| Williams, GH | 1 |
| Aljohmani, AI; Alzoubi, KH; Mayyas, FA | 1 |
| Ji, H; Wang, B | 1 |
| Hodges, MR; Khedr, S; Levchenko, V; Manis, AD; Palygin, O; Staruschenko, A | 1 |
| Wang, Y; Wu, Q; Zhang, M; Zhong, B; Zhu, T | 1 |
| Adler, GK; Baudrand, R; Brooks, D; Garza, AE; Katayama Rangel, IA; Moize, B; Pojoga, LH; Ranjit, S; Romero, JR; Treesaranuwattana, T; Trefts, E; Williams, GH; Yao, TM | 1 |
| Agarwal, A; Cheung, AK | 1 |
| Kelly, DJ; Leader, CJ; Sammut, IA; Walker, RJ; Wilkins, GT | 1 |
| Cohen, JB; Kfoury, B | 1 |
| Ho, JE | 1 |
| Chang, CH; Chung, SD; Hu, YH; Lin, YF; Peng, KY; Wu, VC | 1 |
| O'Connor, CM; Sbolli, M | 1 |
| Bagardi, M; Borromeo, V; Brambilla, PG; Galizzi, A; Locatelli, C; Malchiodi, D; Stranieri, A; Zanaboni, AM | 1 |
| Carceller, E; Fagart, J; Kolkhof, P; Le Billan, F; Lombès, M; Perrot, J; Travers, S; Viengchareun, S | 1 |
| Adin, D; Atkins, C; Klein, A; Wallace, G | 1 |
| Dimke, H; Hansen, PBL; Jensen, BL; Lyngsø, KS | 1 |
| Alesutan, I; Auer, T; Buehling, SS; Degenhart, G; Feger, M; Grebe, S; Hammer, F; Hauser, T; Krane, V; Lang, F; Malzahn, U; Masyout, J; Pasch, A; Tuffaha, R; Voelkl, J; Wanner, C | 1 |
| Aldaz, P; Arozarena, I; Fernández-Celis, A; López-Andrés, N | 1 |
| Baker, ME; Hyodo, S; Katsu, Y; Lin, X; Oana, S | 1 |
| Fan, X; Huang, Z; Lu, C; Tan, X; Yang, J; Zhang, X; Zhou, X | 1 |
| Kidoguchi, S; Kitada, K; Kittikulsuth, W; Kobara, H; Masaki, T; Nakajima, K; Nakano, D; Nishiyama, A; Ohsaki, H; Takahashi, K; Titze, J; Yokoo, T | 1 |
| Baltu, D; Çelik Ertaş, NB; Duzova, A; Gönç, N; Gulhan, B; Ozcan, HN; Özdemir, G; Ünsal, Y; Utine, E | 1 |
| Chang, L; Chen, H; He, L; Tian, R; Wang, Y; Ye, X; Yu, D; Zhang, H; Zhu, B | 1 |
| Asleh, R; Borlaug, BA; Briasoulis, A | 1 |
| Hallow, KM; Maddah, E | 1 |
| Ageev, FT | 1 |
| Habibi, J; Hulse, JL; Igbekele, AE; Jia, G; Li, J; Sowers, JR; Whaley-Connell, A; Zhang, B | 1 |
| Dragomiretskaya, NA; Kucherova, JS; Podzolkov, VI; Tarzimanova, AI | 1 |
| Kometani, M; Mai, X; Yoneda, T | 1 |
| Atmanspacher, F; Grgic, I; Schlüter, KD; Schreckenberg, R; Wolf, A | 1 |
| Chen, Z; Li, Z; Liu, R; Lu, G; Sun, Y; Sun, Z | 1 |
| Dutta, PK; Mandal, C | 1 |
| Antonelli, J; Bruce, A; Dhaliwal, K; Edwards, C; Finlayson, K; Gaughan, E; Husain, F; Kerai, S; Li, F; Malhotra, V; Mills, B; Moore, A; Pandey, NB; Quinn, TM; Saxena, KN; Shankar-Hari, M; Singh, V; Wadhwa, B | 1 |
| Kopkan, L; Majzunova, M; Molcan, L; Sutovska, H; Sykora, M; Zeman, M | 1 |
| Alvarez de la Rosa, D; González-Alayón, C; Hernández, G; Hernández-Guerra, M; Porrini, E; Rodríguez-Rodríguez, AE; Serrano-Morillas, N; Vastola-Mascolo, A | 1 |
| Alexander, S; Baranovskaya, I; Brands, MW; Buncha, V; Cherezova, A; Cherian-Shaw, M; Coleman, KA; Mamenko, M; O'Connor, PM; Sullivan, JC | 1 |
| Quencer, KB; Rugge, JB; Senashova, O | 1 |
| Cooper, D; Farinelli, LA; Farokhnia, M; Leggio, L; Lékó, AH; Pince, CL; Vendruscolo, LF; Wang, T; Whiting, KE | 1 |
| Carroll, R; Corley, B; Feltham, J; Harper, S; Park, W; Whitfield, P | 1 |
168 review(s) available for aldosterone and spironolactone
| Article | Year |
|---|---|
Abnormal regulation of aldosterone in hypertension.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Circadian Rhythm; Diuresis; Female; Humans; Hyperaldosteronism; Hypertension; Metabolic Clearance Rate; Posture; Renin; Sodium; Spironolactone | 1975 |
Renin, aldosterone and glucagon in the natriuresis of fasting.
Topics: Adrenocorticotropic Hormone; Aldosterone; Dietary Carbohydrates; Dietary Proteins; Fasting; Fludrocortisone; Glucagon; Humans; Kidney Tubules, Distal; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Natriuresis; Obesity; Potassium; Renin; Secretory Rate; Sodium; Spironolactone | 1975 |
Spirolactones: clinical and pharmacologic studies.
Topics: Aldosterone; Animals; Binding, Competitive; Canrenoic Acid; Canrenone; Diuresis; Humans; Hyperaldosteronism; Hypertension; In Vitro Techniques; Kidney; Mineralocorticoid Receptor Antagonists; Pregnadienes; Protein Binding; Rats; Receptors, Cell Surface; Spironolactone | 1977 |
Primary aldosteronism.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Renin; Spironolactone | 1977 |
[Primary aldosteronism--aldosterone-induced sodium storing hypertension--symptoms and differential diagnosis].
Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Alkalosis; Animals; Diagnosis, Differential; Dogs; Female; Humans; Hyperaldosteronism; Hypertension; Kallikreins; Kidney; Kinins; Male; Mineralocorticoids; Potassium; Sodium; Spironolactone | 1979 |
Electrical potential difference of colonic mucosa.
Topics: Aldosterone; Biological Transport, Active; Carbenoxolone; Colitis; Colon; Dinitrophenols; Electrodes; Electrophysiology; Epithelium; Humans; Intestinal Mucosa; Ouabain; Proctitis; Sodium; Spironolactone | 1975 |
Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids.
Topics: Aldosterone; Animals; Biological Transport; Carrier Proteins; Cell Size; Desoxycorticosterone; Dogs; Humans; Hydrocortisone; Hypertension; Kidney Tubules; Leukocytes, Mononuclear; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Muscle, Smooth; Potassium; Rats; Receptors, Mineralocorticoid; Second Messenger Systems; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Spironolactone; Swine; Time Factors | 1992 |
Vascular and cardiac actions of aldosterone and spironolactone.
Topics: Aldosterone; Animals; Electrocardiography; Humans; Hypertension; Muscle, Smooth, Vascular; Myocardial Contraction; Spironolactone | 1991 |
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adult; Aldosterone; Child; Desoxycorticosterone; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Renin; Spironolactone | 1990 |
Potassium-sparing diuretics.
Topics: Aldosterone; Amiloride; Animals; Biological Transport; Diuretics; Humans; Ion Channels; Kidney; Potassium; Sodium; Spironolactone; Triamterene | 1987 |
Mechanism of action of aldosterone blockers.
Topics: Aldosterone; Animals; Antihypertensive Agents; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1988 |
Sodium retention after adrenal enucleation.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Biological Assay; Bufo marinus; Corticosterone; Desoxycorticosterone; Female; Homeostasis; Kidney; Male; Natriuresis; Nephrons; Pro-Opiomelanocortin; Rats; Regeneration; Sodium; Spironolactone; Time Factors; Urinary Bladder | 1986 |
Effect of spironolactone on premenstrual syndrome symptoms.
Topics: Adult; Aldosterone; Body Water; Body Weight; Diuretics; Female; Humans; Premenstrual Syndrome; Renin-Angiotensin System; Spironolactone | 1987 |
Disorders of mineralocorticoid activity.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Glands; Adult; Aldosterone; Angiotensin II; Blood Specimen Collection; Brain Neoplasms; Circadian Rhythm; Dexamethasone; Diagnosis, Differential; Evoked Potentials; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Intestinal Mucosa; Mineralocorticoids; Models, Biological; Posture; Radionuclide Imaging; Renin; Spironolactone; Tomography, X-Ray Computed; Ultrasonography | 1985 |
[Hormonal treatment benign prostatic hyperplasia. A review].
Topics: Adult; Aldosterone; Androgens; Castration; Diethylstilbestrol; Estrogens; Hormones; Humans; Male; Middle Aged; Progestins; Prostatectomy; Prostatic Hyperplasia; Spironolactone; Testosterone | 1972 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldosterone; Androgens; Child; Cushing Syndrome; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Infant; Male; Pituitary-Adrenal Function Tests; Renin; Spironolactone; Virilism | 1971 |
Aldosterone: review of its physiology and diagnostic aspects of primary aldosteronism.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Hypokalemia; Potassium; Radiography; Renin; Sodium; Spironolactone | 1973 |
[Renin-angiotensin-aldosterone system in essential hypertension].
Topics: Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Female; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone | 1973 |
[Hepatogenous (secondary) aldosteronism (author's transl)].
Topics: Aldosterone; Angiotensin II; Chronic Disease; Esophageal and Gastric Varices; Hepatitis; Hepatitis A; Humans; Hyperaldosteronism; Liver Diseases; Liver Function Tests; Portacaval Shunt, Surgical; Renin; Spironolactone; Water; Water-Electrolyte Balance | 1974 |
The stimulation of sodium transport by aldosterone.
Topics: Aldosterone; Animals; Binding Sites; Biological Transport, Active; Bufo marinus; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Dactinomycin; Epithelial Cells; Epithelium; Glucose; Kidney; Mineralocorticoid Receptor Antagonists; Protein Binding; Protein Biosynthesis; Puromycin; Rats; Receptors, Drug; RNA; Sodium; Spironolactone; Stimulation, Chemical; Tritium; Urinary Bladder; Vasopressins | 1971 |
[Diagnosis and therapy of primary hyperaldosteronism].
Topics: Adrenal Gland Neoplasms; Aldosterone; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Renin; Spironolactone | 1972 |
Renin and hypertension: a review article.
Topics: Aldosterone; Humans; Hydrochlorothiazide; Hypertension; Juxtaglomerular Apparatus; Kidney Diseases; Renin; Spironolactone; Sympatholytics | 1973 |
Aldosteronism updated.
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Blood Pressure; Dexamethasone; Diagnosis, Differential; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Iodine Radioisotopes; Phlebography; Radioimmunoassay; Radionuclide Imaging; Renin; Spironolactone | 1973 |
The rational management of ascites.
Topics: Albumins; Aldosterone; Animals; Ascites; Ascitic Fluid; Diet, Sodium-Restricted; Diuretics; Dogs; Drainage; Humans; Hypertension, Portal; Infusions, Parenteral; Kidney; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Portacaval Shunt, Surgical; Spironolactone; Water | 1972 |
[Primary hypertension with low plasma renin level].
Topics: Aldosterone; Blood Pressure; Dexamethasone; Diagnosis, Differential; Female; Germany, West; Humans; Hypertension; Juxtaglomerular Apparatus; Male; Mineralocorticoids; Potassium; Prognosis; Renin; Sex Factors; Spironolactone | 1973 |
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carcinoma; Desoxycorticosterone; Female; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney Failure, Chronic; Mineralocorticoids; Pregnancy; Pregnancy Complications, Cardiovascular; Renal Artery Obstruction; Renin; Spironolactone | 1973 |
[Present trends in the diagnosis of primary hyperaldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Desoxycorticosterone; Humans; Hyperaldosteronism; Potassium; Renin; Sodium; Spironolactone | 1974 |
[Low renin essential hypertension].
Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Potassium; Renin; Spironolactone; Trichlormethiazide | 1973 |
Primary hyperaldosteronism.
Topics: Adrenal Gland Neoplasms; Aldosterone; Corticosterone; Desoxycorticosterone; Electrocardiography; Humans; Hyperaldosteronism; Hypokalemia; Kidney Diseases; Renal Artery Obstruction; Renin; Sodium; Spironolactone; Time Factors; Urea | 1974 |
Juxtaglomerular cell hyperplasia and secondary hyperaldosteronism (Bartter's syndrome): a re-evaluation of the pathophysiology.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aldosterone; Child; Child, Preschool; Female; Humans; Hyperaldosteronism; Hyperplasia; Infant; Juxtaglomerular Apparatus; Kidney; Kidney Diseases; Kidney Function Tests; Male; Nephritis; Potassium; Potassium Chloride; Renin; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1968 |
Commentary on incidence of primary aldosteronism: current estimations based on objective data.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Blood Pressure; Desoxycorticosterone; Electrolytes; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Renin; Sodium; Spironolactone; Thiazines | 1969 |
[Role of aldosterone in the pathogenesis of cardiac insufficiency (review of the literature)].
Topics: Aldosterone; Animals; Cats; Chlorine; Depression, Chemical; Dogs; Edema; Heart Failure; Humans; Hyperaldosteronism; Kidney; Kidney Tubules; Liver; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone; Water-Electrolyte Balance | 1967 |
[Pathophysiology of traumatic brain edema. Findings and hypotheses].
Topics: Acid-Base Equilibrium; Aldosterone; Animals; Brain Edema; Brain Injuries; Humans; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone; Water; Water-Electrolyte Balance | 1970 |
[Aldosterone and aldosterone antagonists in surgery].
Topics: Adult; Aldosterone; Blood Volume; Brain Edema; Cardiac Surgical Procedures; Child; Digitalis Glycosides; Diuresis; Drug Antagonism; Drug Synergism; Ethacrynic Acid; Extracellular Space; Furosemide; Heart Diseases; Humans; Hyperaldosteronism; Kidney; Liver; Mineralocorticoid Receptor Antagonists; Postoperative Complications; Potassium; Pulmonary Edema; Sodium; Spironolactone; Surgical Procedures, Operative; Urination Disorders; Water-Electrolyte Balance | 1971 |
[Pharmacological mechanism of modern diuretics. Aldosterone antagonists].
Topics: Aldosterone; Aminoglutethimide; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Humans; Kidney Tubules, Distal; Metyrapone; Mineralocorticoid Receptor Antagonists; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 1984 |
The metabolism and mechanism of action of aldosterone.
Topics: Aldosterone; Animals; Biological Transport, Active; Bufonidae; Chromatography, High Pressure Liquid; Dogs; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Mitochondria; Natriuresis; Potassium; Protein Biosynthesis; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA; Sex Factors; Sodium; Spironolactone; Tissue Distribution; Urinary Bladder | 1981 |
The kinins and prostaglandins in hypertension.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Water; Dinoprost; Female; Furosemide; Humans; Hyperaldosteronism; Hypertension; Indomethacin; Kallikreins; Kidney; Kinins; Male; Natriuresis; Prostaglandins; Prostaglandins E; Prostaglandins F; Renin; Renin-Angiotensin System; Spironolactone | 1981 |
Aldosterone: a telling case of fruitful interplay between biological and clinical research.
Topics: Aldosterone; Amphotericin B; Animals; Biological Transport; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Natriuresis; Research; Skin; Sodium; Spironolactone; Urinary Bladder | 1982 |
Primary hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Amiloride; Diagnosis, Differential; Female; Glucocorticoids; Hemodynamics; Humans; Hyperaldosteronism; Hyperplasia; Kidney; Pregnancy; Radionuclide Imaging; Renin; Spironolactone | 1980 |
Sodium and hypertension. A review of the role of sodium in pathogenesis and the action of diuretic drugs.
Topics: Age Factors; Aldosterone; Amiloride; Benzothiadiazines; Diuretics; Furosemide; Humans; Hypertension; Kidney Diseases; Kidney Tubules, Distal; Loop of Henle; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1980 |
Primary aldosteronism--a review.
Topics: 18-Hydroxycorticosterone; Adenoma; Adolescent; Adrenal Glands; Adult; Aldosterone; Child; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Paraneoplastic Endocrine Syndromes; Posture; Renin; Spironolactone | 1980 |
Mechanism of the antimineralocorticoid effects of spirolactones.
Topics: Aldosterone; Animals; Anura; Canrenoic Acid; Canrenone; Cattle; Guinea Pigs; Humans; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Steroid; Spironolactone; Veratrum Alkaloids | 1981 |
Evaluation of aldosterone antagonists in healthy man.
Topics: Aldosterone; Animals; Diuretics; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Fludrocortisone; Humans; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone | 1982 |
Pathogenesis of mineralocorticoid hypertension.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Aldosterone; Animals; Blood Volume; Body Fluids; Body Weight; Cardiac Output; Desoxycorticosterone; Disease Models, Animal; Female; Humans; Hyperaldosteronism; Hypertension; Kidney; Male; Mineralocorticoids; Natriuresis; Posture; Potassium; Sodium; Spironolactone; Sympathetic Nervous System; Vascular Resistance | 1981 |
"Escape" of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: implications for therapy.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Drug Evaluation; Heart Failure; Humans; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Prospective Studies; Spironolactone | 1995 |
Aldosterone and antialdosterone therapy in congestive heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Diuretics; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin-Angiotensin System; Spironolactone | 1993 |
Angiotensin-converting enzyme inhibitor and spironolactone combination therapy. New objectives in congestive heart failure treatment.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Captopril; Drug Therapy, Combination; Heart; Heart Failure; Humans; Spironolactone | 1993 |
Role of aldosterone in congestive heart failure.
Topics: Aldosterone; Atrial Natriuretic Factor; Heart Failure; Humans; Renin-Angiotensin System; Spironolactone | 1993 |
Aldosterone escape during ACE inhibitor therapy in chronic heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias, Cardiac; Chronic Disease; Drug Therapy, Combination; Endomyocardial Fibrosis; Heart Failure; Humans; Long-Term Care; Mineralocorticoid Receptor Antagonists; Myocardium; Risk Factors; Spironolactone; Treatment Outcome | 1995 |
[Differential diagnosis and therapy of primary hyperaldosteronism].
Topics: Adrenalectomy; Aldosterone; Diagnosis, Differential; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Spironolactone | 1998 |
Primary aldosteronism.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Diagnosis, Differential; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 1998 |
Why does spironolactone improve mortality over and above an ACE inhibitor in chronic heart failure?
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1999 |
Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Drug Industry; Edema; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Spironolactone | 2000 |
Aldosterone and myocardial fibrosis in heart failure.
Topics: Adult; Aldosterone; Animals; Cardiomyopathies; Dose-Response Relationship, Drug; Fibrosis; Heart Failure; Humans; Myocardium; Rats; Spironolactone | 2000 |
The promise of selective aldosterone receptor antagonists for the treatment of hypertension and congestive heart failure.
Topics: Aldosterone; Animals; Antihypertensive Agents; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Spironolactone | 2000 |
Spironolactone in congestive heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 2000 |
Aldosterone, a new appreciation of its role in heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Survival Analysis; Vasoconstriction | 2000 |
[Effect of aldosterone antagonism in heart failure: pharmacotherapeutic options].
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Drug Therapy, Combination; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Severity of Illness Index; Spironolactone | 2001 |
K(+) depletion and the progression of hypertensive disease or heart failure. The pathogenic role of diuretic-induced aldosterone secretion.
Topics: Aldosterone; Animals; Antihypertensive Agents; Benzothiadiazines; Clinical Trials as Topic; Disease Models, Animal; Diuretics; Heart Failure; Humans; Hypertension; Hypokalemia; Mineralocorticoid Receptor Antagonists; Muscles; Potassium; Sodium Chloride Symporter Inhibitors; Spironolactone; Treatment Outcome | 2001 |
Aldosterone as a mediator of progressive renal disease: pathogenetic and clinical implications.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Eplerenone; Humans; Hypertension; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Spironolactone | 2001 |
The spironolactone renaissance.
Topics: Aldosterone; Androgen Antagonists; Angiogenesis Inhibitors; Animals; Clinical Trials as Topic; Collagen; Heart Failure; Humans; Hyperaldosteronism; Hypertension; Spironolactone | 2001 |
Angiotensin receptor blockers and aldosterone antagonists in chronic heart failure.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Heart Failure; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan | 2001 |
Aldosterone as a determinant of cardiovascular and renal dysfunction.
Topics: Aldosterone; Angiotensin II; Animals; Cardiovascular Diseases; Endothelium, Vascular; Fibrosis; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Potassium; Randomized Controlled Trials as Topic; Sodium; Spironolactone | 2001 |
Hyperaldosteronism: recent concepts, diagnosis, and management.
Topics: Aged; Aldosterone; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone | 2001 |
Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biomarkers; Endomyocardial Fibrosis; Extracellular Matrix; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Peptide Fragments; Procollagen; Prognosis; Spironolactone | 2001 |
Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
Topics: Aldosterone; Animals; Cardiovascular System; Clinical Trials as Topic; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Protective Agents; Receptors, Mineralocorticoid; Renin-Angiotensin System; Spironolactone; Tissue Survival | 2001 |
[Primary hyperaldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Algorithms; Amiloride; Diagnosis, Differential; Diuretics; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Length of Stay; Magnetic Resonance Imaging; Middle Aged; Mineralocorticoid Receptor Antagonists; Patient Selection; Potassium; Renin; Spironolactone; Time Factors; Tomography, X-Ray Computed | 1998 |
Rationale for the use of aldosterone antagonists in congestive heart failure.
Topics: Aldosterone; Animals; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 2002 |
Mineralocorticoid receptors and pathophysiological roles for aldosterone in the cardiovascular system.
Topics: Aldosterone; Animals; Cardiomegaly; Cardiovascular System; Heart Failure; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2002 |
The pathophysiology of aldosterone in the cardiovascular system.
Topics: Aldosterone; Animals; Brain; Cardiovascular Diseases; Eplerenone; Heart; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Myocardium; Randomized Controlled Trials as Topic; Salts; Spironolactone | 2002 |
New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone.
Topics: Aldosterone; Animals; Cardiomegaly; Clinical Trials as Topic; Desoxycorticosterone; Eplerenone; Fibrosis; Heart; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Spironolactone | 2002 |
Clinical implications of aldosterone blockade.
Topics: Aldosterone; Antihypertensive Agents; Black People; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Eplerenone; Humans; Hypertension; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Potassium; Renin-Angiotensin System; Spironolactone | 2002 |
[The significance of aldosterone in chronic heart failure: the RALES study].
Topics: Aldosterone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2002 |
The role of aldosterone receptor blockade in the management of cardiovascular disease.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2002 |
Aldosterone: a risk factor for vascular disease.
Topics: Aldosterone; Animals; Arteries; Fibrosis; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Renin-Angiotensin System; Risk Factors; Spironolactone | 2003 |
Eplerenone.
Topics: Aldosterone; Antihypertensive Agents; Clinical Trials as Topic; Drug Approval; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone; United States; United States Food and Drug Administration | 2003 |
[Aldosterone and its antagonists in heart failure].
Topics: Adrenergic beta-Antagonists; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Diuretics; Eplerenone; Heart Failure; Homeostasis; Humans; Mineralocorticoid Receptor Antagonists; Multicenter Studies as Topic; Placebos; Randomized Controlled Trials as Topic; Receptors, Mineralocorticoid; Spironolactone; Time Factors | 2003 |
Eplerenone, a new selective aldosterone blocker.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiovascular System; Disease Models, Animal; Dogs; Eplerenone; Heart Injuries; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Rats; Renin-Angiotensin System; Spironolactone | 2003 |
Aldosterone as a target in congestive heart failure.
Topics: Aldosterone; Cardiovascular Agents; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Plasminogen Activator Inhibitor 1; Progesterone; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome | 2003 |
Eplerenone: cardiovascular protection.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Cardiovascular System; Disease Models, Animal; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Treatment Outcome | 2003 |
Aldosterone resurgens--letter from EPHESUS.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiovascular Diseases; Eplerenone; Humans; Inflammation; Metaphor; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 2003 |
RAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease.
Topics: Aldosterone; Cardiovascular Diseases; Eplerenone; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone | 2003 |
Aldosterone receptor antagonists for hypertension: what do they offer?
Topics: Aldosterone; Clinical Trials as Topic; Diuretics; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Renin-Angiotensin System; Spironolactone | 2003 |
Aldosterone receptor blockade and the role of eplerenone: evolving perspectives.
Topics: Aldosterone; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Eplerenone; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Prognosis; Receptors, Mineralocorticoid; Renal Insufficiency; Risk Assessment; Spironolactone; Survival Analysis; Treatment Outcome | 2003 |
[DRUGS INHIBITING ALDOSTERONE SECRETION AND ALDOSTERONE ANTAGONISTS].
Topics: Aldosterone; Edema; Heparinoids; Hypertension; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Spironolactone | 1963 |
ALDOSTERONE IN CLINICAL MEDICINE.
Topics: Aldosterone; Blood Volume; Body Weight; Desoxycorticosterone; Dexamethasone; Diuretics; Drug Therapy; Edema; Erythrocyte Count; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Liver Cirrhosis; Natriuresis; Organomercury Compounds; Pressoreceptors; Spironolactone; Water-Electrolyte Balance | 1964 |
Aldosterone blockade in patients with systolic left ventricular dysfunction.
Topics: Aldosterone; Eplerenone; Forecasting; Heart Failure; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Patient Selection; Randomized Controlled Trials as Topic; Spironolactone; Systole; Ventricular Dysfunction, Left | 2003 |
Review of aldosterone- and angiotensin II-induced target organ damage and prevention.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiovascular Diseases; Endothelium, Vascular; Eplerenone; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone | 2004 |
[Significance of aldosterone antagonist therapy].
Topics: Aldosterone; Cardiovascular Diseases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Eplerenone; Heart Failure; Hemodynamics; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Receptors, Mineralocorticoid; Spironolactone; Water-Electrolyte Balance | 2004 |
The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade.
Topics: Aldosterone; Autonomic Nervous System Diseases; Endomyocardial Fibrosis; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Vascular Diseases; Water-Electrolyte Imbalance | 2004 |
Evolving role of aldosterone blockers alone and in combination with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in hypertension management: a review of mechanistic and clinical data.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Drug Therapy, Combination; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone | 2004 |
Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Digoxin; Enzyme Inhibitors; Eplerenone; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Randomized Controlled Trials as Topic; Spironolactone; Systole; Ventricular Dysfunction, Left | 2004 |
Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.
Topics: Aldosterone; Anti-Inflammatory Agents; Crystallography, X-Ray; Epithelium; Eplerenone; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Protein Binding; Protein Structure, Tertiary; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Thyroid Hormone; Signal Transduction; Spironolactone; Structure-Activity Relationship | 2004 |
Aldosterone target organ protection by eplerenone.
Topics: Aldosterone; Blood Vessels; Brain; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Receptors, Mineralocorticoid; Spironolactone; Vasculitis, Central Nervous System; Ventricular Remodeling | 2004 |
Eplerenone in the treatment of chronic heart failure.
Topics: Aldosterone; Chronic Disease; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Spironolactone; Treatment Outcome | 2004 |
[Involvement of Aldosterone and mineralocorticoid receptor in pathogenesis of cardiovascular diseases].
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Angiotensin II; Cardiovascular Diseases; Fibrosis; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Myocardium; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone | 2004 |
The role of aldosterone and aldosterone-receptor antagonists in heart failure.
Topics: Aldosterone; Eplerenone; Fibrosis; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone | 2004 |
Mineralocorticoid receptor antagonists and hypertension: is there a rationale?
Topics: Albuminuria; Aldosterone; Animals; Drug Therapy, Combination; Eplerenone; Humans; Hyperkalemia; Hypertension; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone; Vasodilation | 2004 |
Rapid effects of aldosterone on vascular cells: clinical implications.
Topics: Aldosterone; Cardiovascular Diseases; Cardiovascular System; Clinical Trials as Topic; Cyclic AMP Response Element-Binding Protein; Endothelial Cells; Humans; Mineralocorticoid Receptor Antagonists; Phosphorylation; Receptors, Mineralocorticoid; Spironolactone; Vascular Resistance | 2004 |
The clinical implications of aldosterone escape in congestive heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Death, Sudden, Cardiac; Endothelium, Vascular; Eplerenone; Fibrosis; Heart Failure; Humans; Myocardium; Spironolactone; Ventricular Remodeling | 2004 |
Eplerenone: a new selective aldosterone receptor antagonist.
Topics: Aldosterone; Animals; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2004 |
Nuclear envelope: nanoarray responsive to aldosterone.
Topics: Aldosterone; Amiloride; Animals; Cell Membrane; Cell Nucleus; Humans; Macromolecular Substances; Microarray Analysis; Microscopy, Atomic Force; Nuclear Envelope; Nuclear Pore; Sodium Channels; Spironolactone | 2004 |
[Aldosterone antagonist therapy for chronic heart failure].
Topics: Aldosterone; Chronic Disease; Death, Sudden, Cardiac; Diuretics; Eplerenone; Fibrosis; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Randomized Controlled Trials as Topic; Spironolactone; Sulfonamides; Torsemide; Ventricular Remodeling | 2005 |
Pleiotropic actions of aldosterone and the effects of eplerenone, a selective mineralocorticoid receptor antagonist.
Topics: Aldosterone; Animals; Drug Interactions; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2004 |
Cardiovascular effects of aldosterone.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2005 |
Autonomic effects of spironolactone and MR blockers in heart failure.
Topics: Aldosterone; Autonomic Nervous System; Diuretics; Heart Failure; Heart Rate; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2005 |
[Roll of aldosterone in pathogenesis of kidney disorders].
Topics: Aldosterone; Animals; Body Water; Disease Models, Animal; Eplerenone; Humans; Hypertension; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Potassium; Proteinuria; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2005 |
Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone.
Topics: Aldosterone; Animals; Eplerenone; Heart Failure; Hypertension; Ligands; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone; Transcription, Genetic | 2005 |
[Recent insights into the role of aldosterone in physiology, pathology and therapy].
Topics: Aldosterone; Cardiovascular Diseases; Eplerenone; Humans; Spironolactone | 2005 |
Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade.
Topics: Aldosterone; Animals; Cell Proliferation; Cell Shape; Cells, Cultured; Collagen; Eplerenone; Fibroblasts; Fibrosis; Humans; Kidney; Kidney Diseases; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2006 |
Mineralocorticoid receptor blockade in the protection of target organ damage.
Topics: Aldosterone; Animals; Brain; Brain Diseases; Cardiovascular Diseases; Eplerenone; Heart; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2006 |
The pharmacological treatment of primary aldosteronism.
Topics: Aldosterone; Amiloride; Calcium Channel Blockers; Clinical Trials as Topic; Drug Therapy, Combination; Glucocorticoids; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Practice Guidelines as Topic; Receptors, Mineralocorticoid; Sodium Channel Blockers; Spironolactone | 2006 |
Aldosterone receptor antagonists and cardiovascular disease: do we need a change of the guard?
Topics: Aldosterone; Cardiovascular Diseases; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Spironolactone | 2006 |
[Clinical characteristics of primary and secondary aldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Diagnosis, Differential; Drug Therapy, Combination; Edema; Furosemide; Humans; Hyperaldosteronism; Prognosis; Renin; Renin-Angiotensin System; Spironolactone | 2006 |
[Idiopathic hyperaldosteronism (IHA)].
Topics: Adrenal Cortex; Aldosterone; Diagnosis, Differential; Humans; Hyperaldosteronism; Hyperplasia; Mineralocorticoid Receptor Antagonists; Prognosis; Spironolactone | 2006 |
[Adrenocortical adenoma].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Androgens; Biomarkers; Calcium Channel Blockers; Diagnostic Imaging; Dihydrotestosterone; Enzyme Inhibitors; Humans; Hydrocortisone; Metyrapone; Spironolactone | 2006 |
[Cardiovascular action of aldosterone].
Topics: Aldosterone; Animals; Cardiovascular Diseases; Endothelium, Vascular; Epithelial Sodium Channels; Eplerenone; Fibrosis; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Oxidative Stress; Receptors, Mineralocorticoid; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Spironolactone | 2006 |
[Cardioprotective effect of aldosterone antagonists for ventricular remodeling].
Topics: Aldosterone; Animals; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone; Ventricular Remodeling | 2006 |
Aldosterone blockade: an emerging strategy for abrogating progressive renal disease.
Topics: Aldosterone; Algorithms; Disease Progression; Disease Susceptibility; Drug Labeling; Eplerenone; Fibrosis; Heart Failure; Humans; Hyperkalemia; Kidney; Mineralocorticoid Receptor Antagonists; Renal Agents; Renal Insufficiency; Spironolactone | 2006 |
Aldosterone blockade over and above ACE-inhibitors in patients with coronary artery disease but without heart failure.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Clinical Trials as Topic; Coronary Artery Disease; Diabetes Mellitus, Type 2; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2006 |
[Treatment for symptoms of pseudoaldosteronism].
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Diet, Sodium-Restricted; Glycyrrhiza; Glycyrrhizic Acid; Humans; Hydrocortisone; Hyperaldosteronism; Kidney Tubules, Collecting; Mineralocorticoid Receptor Antagonists; Potassium; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2007 |
[Aldosterone antagonists: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].
Topics: Aldosterone; Chronic Disease; Contraindications; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Prognosis; Randomized Controlled Trials as Topic; Spironolactone; Survival Rate | 2007 |
Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues.
Topics: Aldosterone; Contraindications; Drug Therapy, Combination; Eplerenone; Heart Failure; Humans; Hypertension; Kaplan-Meier Estimate; Mineralocorticoid Receptor Antagonists; Practice Guidelines as Topic; Spironolactone | 2007 |
[Role of aldosterone in oxidative stress and renal injury].
Topics: Aldosterone; Animals; Cardiovascular Diseases; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Rats; Reactive Oxygen Species; Receptors, Mineralocorticoid; Renal Insufficiency; Spironolactone | 2007 |
[Molecular mechanism of cardiovascular damage induced by aldosterone].
Topics: Aldosterone; Animals; Biopterins; Cardiovascular Diseases; Cells, Cultured; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphoprotein Phosphatases; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2007 |
Mineralocorticoid receptor antagonists and endothelial function.
Topics: Aldosterone; Animals; Endocrine System Diseases; Endothelium, Vascular; Eplerenone; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 2008 |
Obesity, sleep apnea, aldosterone, and hypertension.
Topics: Aldosterone; Humans; Hypertension; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Obesity; Risk Factors; Sleep Apnea, Obstructive; Spironolactone; Sympathetic Nervous System | 2008 |
Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury.
Topics: Aldosterone; Animals; Eplerenone; Humans; Kidney; Kidney Diseases; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Receptors, Mineralocorticoid; rho-Associated Kinases; Spironolactone | 2008 |
Effects of eplerenone, a selective mineralocorticoid receptor antagonist, on clinical and experimental salt-sensitive hypertension.
Topics: Aldosterone; Animals; Disease Models, Animal; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Dahl; Sodium Chloride; Spironolactone | 2009 |
Role of aldosterone in the progression of chronic kidney disease and potential use of aldosterone blockade in children.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Child; Disease Progression; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone | 2009 |
Aldosterone-receptor antagonism in hypertension.
Topics: Albuminuria; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Arrhythmias, Cardiac; Drug Therapy, Combination; Electrocardiography; Eplerenone; Fibrosis; Glomerular Filtration Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone | 2009 |
Blocking aldosterone in heart failure.
Topics: Aldosterone; Cardiovascular Agents; Drug Therapy, Combination; Eplerenone; Fibrosis; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Remodeling | 2009 |
Aldosterone in uremia - beyond blood pressure.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Endothelial Cells; Endothelium, Vascular; Humans; Hydrocortisone; Hyperaldosteronism; Hyperkalemia; Hypertension; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin-Angiotensin System; Sodium; Sodium, Dietary; Spironolactone; Uremia; Vascular Resistance | 2010 |
Understanding the risk of hyperkalaemia in heart failure: role of aldosterone antagonism.
Topics: Aldosterone; Diuretics; Evidence-Based Medicine; Heart Failure; Humans; Hyperkalemia; Mineralocorticoid Receptor Antagonists; Spironolactone | 2010 |
[Chronic kidney disease and the aldosterone/mineralocorticoid receptor system].
Topics: Aldosterone; Animals; Chronic Disease; Eplerenone; Humans; Kidney Diseases; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Podocytes; Proteinuria; Receptors, Mineralocorticoid; Risk Factors; Spironolactone | 2010 |
Mineralocorticoid receptor antagonists and the metabolic syndrome.
Topics: Aldosterone; Antihypertensive Agents; Eplerenone; Humans; Hypertension; Inflammation; Insulin Resistance; Lipid Metabolism; Lipids; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Obesity; Signal Transduction; Spironolactone | 2010 |
Aldosterone, hypertension and heart failure: insights from clinical trials.
Topics: Aldosterone; Animals; Anticholesteremic Agents; Atorvastatin; Clinical Trials as Topic; Dihydrotestosterone; Drug Therapy, Combination; Enzyme Inhibitors; Female; Heart Failure; Heptanoic Acids; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Mice; Mineralocorticoid Receptor Antagonists; Ouabain; Pyrroles; Quinolines; Rats; Spironolactone | 2010 |
[Prothrombotic aldosterone action--a new side of the hormone].
Topics: Aldosterone; Animals; Eplerenone; Hemostasis; Platelet Adhesiveness; Rats; Spironolactone; Thrombosis | 2010 |
Aldosterone antagonists in heart failure.
Topics: Aldosterone; Animals; Eplerenone; Heart Failure; Humans; Hyperkalemia; Mineralocorticoid Receptor Antagonists; Patient Selection; Severity of Illness Index; Spironolactone | 2011 |
Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney.
Topics: Aldosterone; Animals; Blood Pressure; Electrolytes; Eplerenone; Homeostasis; Humans; Kidney; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Rats; Receptors, Mineralocorticoid; Renal Circulation; Spironolactone | 2011 |
Aldosterone-induced fibrosis in the kidney: questions and controversies.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Antihypertensive Agents; Blood Pressure; Child, Preschool; Chronic Disease; Female; Fibrosis; Humans; Hyperaldosteronism; Kidney; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Sodium; Spironolactone; Wound Healing | 2011 |
Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1.
Topics: Aldosterone; Animals; Connective Tissue Growth Factor; Eplerenone; Glomerulonephritis; I-kappa B Proteins; Immediate-Early Proteins; Intercellular Adhesion Molecule-1; Kidney; MAP Kinase Kinase 1; Mesangial Cells; Mineralocorticoid Receptor Antagonists; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Rats; Spironolactone | 2012 |
Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling.
Topics: Aldosterone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone; Ventricular Remodeling | 2011 |
Mineralocorticoid receptor antagonists for heart failure.
Topics: Aldosterone; Animals; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome | 2011 |
The role of mineralocorticoid receptor antagonists in patients with American College of Cardiology/American Heart Association stage B heart failure.
Topics: Adrenal Glands; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Endothelium, Vascular; Glomerular Filtration Rate; Heart Failure; Humans; Hydrocortisone; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone | 2012 |
Resistant hypertension and aldosterone: an update.
Topics: Aldosterone; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Hypertension; Male; Prognosis; Risk Assessment; Severity of Illness Index; Sleep Apnea, Obstructive; Spironolactone; Treatment Outcome | 2012 |
Eplerenone for the treatment of cardiovascular disorders.
Topics: Aldosterone; Animals; Cardiovascular Agents; Cardiovascular Diseases; Eplerenone; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2012 |
[Primay hyperaldosteronism--diagnostic and treatment].
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Adenoma; Aldosterone; Antihypertensive Agents; Diagnosis, Differential; Eplerenone; Hyperaldosteronism; Hypertension; Hypokalemia; Magnetic Resonance Imaging; Mass Screening; Renin; Spironolactone; Tomography, X-Ray Computed | 2012 |
[Resistant hypertension].
Topics: Age Factors; Aldosterone; Coronary Vasospasm; Disease Management; Diuretics; Humans; Hyperaldosteronism; Hypertension; Obesity; Prognosis; Sedentary Behavior; Sex Factors; Spironolactone | 2012 |
Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Eplerenone; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 2013 |
Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease.
Topics: Adrenalectomy; Aldosterone; Animals; Bone Density; Bone Diseases; Calcium; Cardiovascular Diseases; Fibrosis; Humans; Hyperaldosteronism; Hyperparathyroidism, Secondary; Hypocalcemia; Magnesium; Mineralocorticoid Receptor Antagonists; Myocardium; Parathyroid Hormone; Parathyroidectomy; Spironolactone | 2014 |
Aldosterone and volume management in hypertensive heart disease.
Topics: Aldosterone; Area Under Curve; Diuretics; Eplerenone; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Renal Insufficiency, Chronic; Spironolactone | 2014 |
[Primary hyperaldosteronism: boundaries of diagnostics and therapy].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adrenocortical Hyperfunction; Aldosterone; Coronary Vasospasm; Cross-Sectional Studies; Diagnosis, Differential; Humans; Hyperaldosteronism; Hypertension; Laparoscopy; Mass Screening; Renin; Spironolactone | 2014 |
Impact of aldosterone on osteoinductive signaling and vascular calcification.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Humans; Hyperphosphatemia; Mice; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Renal Insufficiency, Chronic; Signal Transduction; Sodium-Phosphate Cotransporter Proteins, Type III; Spironolactone; Vascular Calcification | 2014 |
[Hypertension in the course of primary aldosteronism during pregnancy].
Topics: Acid Sensing Ion Channel Blockers; Aldosterone; Amiloride; Antihypertensive Agents; Eplerenone; Female; Humans; Hyperaldosteronism; Hypertension; Poland; Pregnancy; Pregnancy Complications; Progesterone; Spironolactone | 2015 |
Pharmacological treatment of aldosterone excess.
Topics: Aldosterone; Cytochrome P-450 CYP11B2; Dihydropyridines; Drug Interactions; Epithelial Sodium Channel Blockers; Eplerenone; Glucocorticoids; Heart Failure; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2015 |
Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone.
Topics: Aldosterone; Drug Interactions; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 2015 |
Spironolactone for Management of Heart Failure with Preserved Ejection Fraction: Whither to After TOPCAT?
Topics: Aldosterone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome | 2015 |
Mineralocorticoid receptor antagonists and atrial fibrillation: a meta-analysis.
Topics: Aldosterone; Atrial Fibrillation; Cardiac Surgical Procedures; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 2016 |
Mineralocorticoid Receptor Antagonists in End-Stage Renal Disease: Efficacy and Safety.
Topics: Aldosterone; Blood Pressure; Disease Progression; Eplerenone; Heart Failure; Humans; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Patient Safety; Randomized Controlled Trials as Topic; Renal Dialysis; Renal Insufficiency, Chronic; Spironolactone; Stroke Volume; Survival Analysis; Treatment Outcome; Ventricular Remodeling | 2016 |
Resistant Hypertension and the Pivotal Role for Mineralocorticoid Receptor Antagonists: A Clinical Update 2016.
Topics: Age Factors; Aldosterone; Blood Pressure Monitoring, Ambulatory; Comorbidity; Diabetes Mellitus; Humans; Hyperkalemia; Hypertension; Mineralocorticoid Receptor Antagonists; Renal Insufficiency, Chronic; Spironolactone; Vascular Stiffness; Water-Electrolyte Imbalance | 2016 |
Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic differences.
Topics: Aldosterone; Animals; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2016 |
Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives.
Topics: Aldosterone; Androstadienes; Androstenes; Animals; Canrenone; Chloranil; Dehydroepiandrosterone; Eplerenone; Humans; Molecular Structure; Receptors, Mineralocorticoid; Spironolactone | 2017 |
Eplerenone Versus Spironolactone in Resistant Hypertension: an Efficacy and/or Cost or Just a Men's Issue?
Topics: Aldosterone; Antihypertensive Agents; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2019 |
[Antifibrotic renal role of mineralcorticoid receptor antagonists].
Topics: Aldosterone; Body Fluids; Cardiovascular Diseases; Clinical Trials as Topic; Cytokines; Diabetic Nephropathies; Eplerenone; Fibrosis; Heart; Heart Diseases; Homeostasis; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Naphthyridines; Receptors, Mineralocorticoid; Renal Insufficiency, Chronic; Spironolactone | 2019 |
Spontaneous Remission of Primary Aldosteronism with Mineralocorticoid Receptor Antagonist Therapy: A Review.
Topics: Aldosterone; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Remission, Spontaneous; Renin; Spironolactone | 2022 |
Research Progress on the Efficacy and Safety of Spironolactone in Reversing Left Ventricular Hypertrophy in Hemodialysis Patients.
Topics: Aldosterone; Heart Failure; Humans; Hypertrophy, Left Ventricular; Multicenter Studies as Topic; Prospective Studies; Renal Dialysis; Spironolactone; Stroke Volume; Ventricular Function, Left | 2023 |
Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review.
Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2023 |
101 trial(s) available for aldosterone and spironolactone
| Article | Year |
|---|---|
The role of renin in the antihypertensive action of beta-adrenoreceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Depression, Chemical; Humans; Oxprenolol; Pindolol; Propranolol; Rabbits; Renin; Spironolactone | 1976 |
Spironolactone and hydrochlorothiazide in normal-renin and low-renin essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Radioimmunoassay; Renin; Spironolactone | 1977 |
Renin-aldosterone profiling in hypertension.
Topics: Aldosterone; Angiotensin II; Benzothiadiazines; Clinical Trials as Topic; Diagnosis, Differential; Diuretics; Dopamine beta-Hydroxylase; Humans; Hyperaldosteronism; Hypertension; Norepinephrine; Propranolol; Renin; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene | 1977 |
[Search for ways to correct volemic disorders in thyrotoxicosis before surgery].
Topics: Aldosterone; Blood Volume; Circadian Rhythm; Clinical Trials as Topic; Drug Evaluation; Humans; Hyperaldosteronism; Hyperthyroidism; Preoperative Care; Spironolactone; Water-Electrolyte Balance | 1977 |
Response of blood pressure and the renin-angiotensin-aldosterone axis to hypotensive therapy: comparison of propranolol with spironolactone.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Clinical Trials as Topic; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Propranolol; Renin; Spironolactone | 1977 |
[Spironolactone-induced changes of the renin-angiotensin-aldosterone system and blood pressure lowering in essential hypertension].
Topics: Aldosterone; Angiotensin II; Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Humans; Hypertension; Renin; Spironolactone | 1977 |
Relationships of renin and aldosterone to antihypertensive effects of spironolactone and propranolol.
Topics: Adult; Aldosterone; Antihypertensive Agents; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Propranolol; Renin; Sodium; Spironolactone; Time Factors | 1978 |
[Effect of aldactone on the mineralocorticoid function of the adrenal cortex and the sodium and potassium content in the blood of middle-aged and elderly persons].
Topics: Adrenal Cortex; Adult; Aged; Aging; Aldosterone; Clinical Trials as Topic; Drug Evaluation; Erythrocytes; Female; Humans; Male; Middle Aged; Mineralocorticoids; Potassium; Sodium; Spironolactone | 1978 |
Hydrochlorothiazide and spironolactone in hypertension.
Topics: Adult; Aldosterone; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Renin; Spironolactone; Uric Acid | 1979 |
Treatment of premenstrual syndrome by spironolactone.
Topics: Aldosterone; Body Weight; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Menstruation; Premenstrual Syndrome; Progesterone; Random Allocation; Spironolactone | 1979 |
Controlled treatment of primary hypertension with propranolol and spironolactone. A crossover study with special reference to initial plasma renin activity.
Topics: Adult; Aldosterone; Angiotensin II; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Posture; Potassium; Propranolol; Renin; Sodium; Spironolactone | 1976 |
Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.
Topics: Adult; Aldosterone; Body Weight; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Plasma Volume; Potassium; Renin; Sodium; Spironolactone | 1975 |
Influence of spironolactone on endogenous steroid metabolism in man.
Topics: Adrenal Cortex Hormones; Adult; Aldosterone; Humans; Male; Metabolism; Renin; Sodium; Spironolactone; Triamterene | 1976 |
Intrapatient comparison of treatment with chlorthalidone, spironolactone and propranolol in normoreninemic essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Creatinine; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Propranolol; Renin; Sodium; Spironolactone; Water-Electrolyte Balance | 1975 |
Sodium balance and renal tubular sensitivity to aldosterone during total fast and carbohydrate refeeding in the obese.
Topics: Aldosterone; Fasting; Female; Glucose; Humans; Kidney Tubules; Natriuresis; Obesity; Spironolactone; Time Factors | 1976 |
Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-over.
Topics: Aldosterone; Canrenoic Acid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperaldosteronism; Liver Cirrhosis; Liver Function Tests; Male; Pregnadienes; Random Allocation; Spironolactone | 1988 |
A double-blind, placebo-controlled evaluation of spironolactone in the premenstrual syndrome.
Topics: Adult; Aldosterone; Double-Blind Method; Drug Evaluation; Female; Humans; Middle Aged; Patient Dropouts; Premenstrual Syndrome; Random Allocation; Spironolactone | 1987 |
Assessment of the antimineralocorticoid effect of RU 28318 in healthy men with induced exogenous and endogenous hypermineralocorticism.
Topics: Adult; Aldosterone; Clinical Trials as Topic; Double-Blind Method; Fludrocortisone; Furosemide; Humans; Hyperaldosteronism; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Time Factors | 1985 |
[Creatinine elimination rate as reference value for analysis of urine samples. I. Effect of daily urine volume and circadian rhythm on creatinine excretion].
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Chemistry, Clinical; Circadian Rhythm; Clinical Trials as Topic; Creatinine; Female; Humans; Male; Methylprednisolone; Metyrapone; Middle Aged; Spironolactone; Urine | 1970 |
18-Hydroxy-deoxycorticosterone in human hypertension.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Blood Pressure; Catheterization; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Dexamethasone; Humans; Hypertension; Liver Extracts; Mass Spectrometry; Mineralocorticoids; Radioisotope Dilution Technique; Renin; Sodium; Spironolactone; Tritium | 1971 |
Treatment of low-renin essential hypertension. Comparison of spironolactone and a hydrochlorothiazide-triamterene combination.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Drug Therapy, Combination; Extracellular Space; Female; Humans; Hydrochlorothiazide; Hypertension; Informed Consent; Male; Middle Aged; Placebos; Posture; Potassium; Renin; Sodium; Spironolactone; Triamterene | 1974 |
[31 weeks of a regime of diuretics and low-salt diets. Illustration of several unwanted side effects].
Topics: Adult; Aldosterone; Benzothiadiazines; Clinical Trials as Topic; Diet, Sodium-Restricted; Diuretics; Drug Combinations; Humans; Male; Potassium; Renin; Sodium; Spironolactone | 1974 |
Effect of spironolactone on aldosterone regulation in man.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Corticosterone; Humans; Hydrocortisone; Male; Potassium; Renin; Sodium; Spironolactone | 1980 |
Interaction of diuretics and non-steroidal anti-inflammatory drugs in man.
Topics: Adult; Aldosterone; Creatinine; Diuretics; Drug Interactions; Female; Furosemide; Humans; Hydrochlorothiazide; Indomethacin; Male; Potassium; Prostaglandins E; Prostaglandins F; Renin; Sodium; Spironolactone; Triamterene; Vasopressins | 1983 |
[Clinical study of the efficacy of oral potassium canrenoate and spironolactone in essential arterial hypertension].
Topics: Administration, Oral; Adult; Aldosterone; Blood Pressure; Canrenoic Acid; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pregnadienes; Renin; Spironolactone; Time Factors | 1983 |
Spironolactone and triamterene in volume-dependent essential hypertension.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Plasma Volume; Renin; Spironolactone; Triamterene | 1980 |
Spironolactone in thiazide-induced hypokalaemia: variable response between patients.
Topics: Adult; Aldosterone; Benzothiadiazines; Canrenone; Diuretics; Electrolytes; Female; Humans; Hypokalemia; Male; Middle Aged; Potassium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1981 |
[Spironolactone in essential hypertension associated with abnormal aldosterone regulation and in Conn's syndrome (author's transl)].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Spironolactone | 1980 |
Combined therapy of captopril and spironolactone for refractory congestive heart failure.
Topics: Adult; Aged; Aldosterone; Captopril; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Middle Aged; Spironolactone | 1994 |
Spironolactone administration and training-induced hypervolemia.
Topics: Adolescent; Adult; Aldosterone; Blood Proteins; Exercise; Humans; Male; Middle Aged; Plasma Volume; Spironolactone | 1994 |
Treatment of patients with IVCS and gross oedema and ascites with diuretic combination and ACE-inhibitors: relation to baseline PRA and PAC.
Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Ascites; Captopril; Diuretics; Drug Therapy, Combination; Edema; Female; Furosemide; Humans; Male; Middle Aged; Renin; Spironolactone; Vascular Diseases; Vena Cava, Inferior | 1995 |
[Effect of veroshpiron on hormone level in patients with Parkinson's disease].
Topics: Adrenal Cortex Hormones; Adult; Aged; Aldosterone; Humans; Middle Aged; Parkinson Disease; Spironolactone | 1994 |
A comparison of the potassium and magnesium-sparing properties of amiloride and spironolactone in diuretic-treated normal subjects.
Topics: Adult; Aldosterone; Amiloride; Double-Blind Method; Drug Interactions; Erythrocytes; Humans; Hydrochlorothiazide; Intracellular Fluid; Magnesium; Male; Potassium; Spironolactone | 1993 |
ACE inhibitor co-therapy in patients with heart failure: rationale for the Randomized Aldactone Evaluation Study (RALES).
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Survival Rate | 1995 |
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea.
Topics: Adult; Aldosterone; Body Weight; Cathartics; Diarrhea; Electrolytes; Feces; Female; Fludrocortisone; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Phenolphthalein; Phenolphthaleins; Potassium; Renin; Serum Albumin; Sodium; Spironolactone; Water | 1997 |
Diuretic requirements after therapeutic paracentesis in non-azotemic patients with cirrhosis. A randomized double-blind trial of spironolactone versus placebo.
Topics: Aldosterone; Ascites; Combined Modality Therapy; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Liver Cirrhosis; Male; Middle Aged; Paracentesis; Radioimmunoassay; Recurrence; Renin; Sodium; Spironolactone; Treatment Outcome; Uremia | 1997 |
Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Follow-Up Studies; Heart Rate; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Radioimmunoassay; Renin; Spironolactone; Treatment Outcome | 1999 |
Raised aldosterone to renin ratio predicts antihypertensive efficacy of spironolactone: a prospective cohort follow-up study.
Topics: Aldosterone; Anti-Inflammatory Agents; Antihypertensive Agents; Female; Fludrocortisone; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prospective Studies; Renin; Spironolactone | 1999 |
Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure.
Topics: Aged; Aldosterone; Cardiac Volume; Endomyocardial Fibrosis; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Prospective Studies; Spironolactone; Stroke Volume; Ventricular Function, Left; Ventricular Remodeling | 2001 |
Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Diuretics; Double-Blind Method; Fibrinolysis; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Sodium Chloride Symporter Inhibitors; Spironolactone | 2002 |
Spironolactone improves cardiac sympathetic nerve activity and symptoms in patients with congestive heart failure.
Topics: 3-Iodobenzylguanidine; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Digoxin; Diuretics; Drug Therapy, Combination; Female; Heart; Heart Failure; Humans; Iodine Radioisotopes; Male; Radionuclide Imaging; Radiopharmaceuticals; Spironolactone; Stroke Volume; Sympathetic Nervous System | 2002 |
Effect of spironolactone on impaired fibrinolysis of hypertensive patients.
Topics: Adult; Aged; Aldosterone; Female; Fibrinolysis; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Spironolactone; Tissue Plasminogen Activator | 2002 |
Hyperaldosteronism among black and white subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Alabama; Aldosterone; Black People; Blood Pressure; Diuretics; Drug Resistance; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Predictive Value of Tests; Prevalence; Prospective Studies; Renin; Sensitivity and Specificity; Sodium Chloride, Dietary; Spironolactone; White People | 2002 |
Effectiveness of aldosterone blockade in patients with diabetic nephropathy.
Topics: Albuminuria; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Therapy, Combination; Female; Heart Ventricles; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Ultrasonography | 2003 |
Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients.
Topics: Adult; Aldosterone; Analysis of Variance; Angiotensin Receptor Antagonists; Antihypertensive Agents; Black People; Blood Pressure; Double-Blind Method; Eplerenone; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone; Treatment Outcome; White People | 2003 |
Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension.
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Eplerenone; Female; Heart Rate; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Spironolactone | 2003 |
Safety of low-dose spironolactone administration in chronic haemodialysis patients.
Topics: Adult; Aged; Aldosterone; Canrenone; Humans; Hyperkalemia; Kidney Failure, Chronic; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Renal Dialysis; Spironolactone | 2003 |
Is spironolactone safe for dialysis patients?
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Female; Humans; Hyperkalemia; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Renal Dialysis; Renin; Spironolactone | 2003 |
Efficacy of low-dose spironolactone in subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone; Treatment Outcome | 2003 |
Effect of spironolactone on K(+) homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients.
Topics: Adolescent; Adult; Aged; Aldosterone; Dietary Carbohydrates; Epithelial Sodium Channels; Female; Homeostasis; Humans; Kidney Failure, Chronic; Lymphocytes; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium, Dietary; Renal Dialysis; RNA, Messenger; Sodium Channels; Spironolactone | 2004 |
Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension.
Topics: Aldosterone; Arteries; Bendroflumethiazide; Blood Flow Velocity; Blood Pressure; Compliance; Cross-Over Studies; Diuretics; Female; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Single-Blind Method; Spironolactone; Treatment Outcome | 2005 |
RALES, EPHESUS and redox.
Topics: Aldosterone; Animals; Heart Failure; Humans; Inflammation; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2005 |
Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients.
Topics: Adult; Aldosterone; Antihypertensive Agents; Anuria; Blood Pressure; Body Weight; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Oliguria; Potassium; Renal Dialysis; Renin-Angiotensin System; Spironolactone; Weight Gain | 2005 |
Central role for ENaC in development of hypertension.
Topics: Aldosterone; Amiloride; Antihypertensive Agents; Blood Pressure; Epithelial Sodium Channels; Humans; Hypertension; Risk Factors; Sodium; Sodium Channels; Spironolactone; Urothelium | 2005 |
Beneficial impact of spironolactone in diabetic nephropathy.
Topics: Adult; Aldosterone; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Humans; Hypertension, Renal; Linear Models; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Treatment Outcome | 2005 |
The effects of treatment with octreotide, diuretics, or both on portal hemodynamics in nonazotemic cirrhotic patients with ascites.
Topics: Adult; Aged; Aldosterone; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Gastrointestinal Agents; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Octreotide; Portal System; Portal Vein; Renin; Renin-Angiotensin System; Spironolactone; Ultrasonography, Doppler | 2006 |
Effects of spironolactone during an angiotensin II receptor blocker treatment on the left ventricular mass reduction in hypertensive patients with concentric left ventricular hypertrophy.
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Echocardiography; Female; Heart Ventricles; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Natriuretic Peptide, Brain; Spironolactone; Tetrazoles; Ventricular Remodeling | 2006 |
Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism.
Topics: Adult; Aldosterone; Angiotensin II; Cross-Over Studies; Diet, Sodium-Restricted; Double-Blind Method; Female; Humans; Hydroxycorticosteroids; Infusions, Intravenous; Interleukin-6; Male; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Receptors, Mineralocorticoid; Spironolactone | 2006 |
Treatment of polycystic ovary syndrome with spironolactone plus licorice.
Topics: Adult; Aldosterone; Androgens; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Glycyrrhiza; Humans; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Polycystic Ovary Syndrome; Receptors, Mineralocorticoid; Renin; Renin-Angiotensin System; Spironolactone | 2007 |
Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study.
Topics: Aldosterone; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Renin; Spironolactone | 2007 |
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio.
Topics: Aged; Aldosterone; Amiloride; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Renin; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Spironolactone | 2007 |
Spironolactone has antiarrhythmic activity in ischaemic cardiac patients without cardiac failure.
Topics: Aged; Aldosterone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Forearm; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Ischemia; Peptide Fragments; Procollagen; Spironolactone | 2007 |
Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients.
Topics: Aldosterone; Analysis of Variance; Blood Pressure; Chlorthalidone; Cross-Over Studies; Diuretics; Heart Rate; Humans; Hypertension; Insulin; Muscle, Skeletal; Potassium; Renin; Spironolactone; Sympathetic Nervous System | 2009 |
Role of vasopressin and aldosterone in pulmonary arterial hypertension: A pilot study.
Topics: Aldosterone; Health Status Indicators; Humans; Hypertension, Pulmonary; Mineralocorticoid Receptor Antagonists; Pilot Projects; Pulmonary Artery; Research; Spironolactone; Vasoconstrictor Agents; Vasopressins; Ventricular Dysfunction, Right | 2009 |
Aldosterone excess or escape: Treating resistant hypertension.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Drug Resistance; Endothelium, Vascular; Humans; Hypertension; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Renin-Angiotensin System; Sodium; Spironolactone | 2009 |
Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO.
Topics: Aldosterone; Bendroflumethiazide; Blood Pressure; Cross-Over Studies; Diuretics; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Predictive Value of Tests; Renin; Spironolactone; Treatment Outcome | 2010 |
[Does spironolactone use at arterial hypertension therapy protect endothelium also in smoking patients?].
Topics: Aldosterone; Diuretics; Endothelin-1; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Renin; Smoking; Spironolactone | 2009 |
Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system function in geriatric hypertension.
Topics: Aged; Aldosterone; Blood Pressure; Body Composition; Catecholamines; Diuretics; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Norepinephrine; Patient Selection; Spironolactone; Sympathetic Nervous System | 2010 |
Rationale and design of the 'aldosterone receptor blockade in diastolic heart failure' trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in pa
Topics: Aldosterone; Diastole; Disease Progression; Diuretics; Double-Blind Method; Exercise Tolerance; Health Status Indicators; Heart Failure, Diastolic; Humans; Mineralocorticoid Receptor Antagonists; Oxygen Consumption; Placebos; Research Design; Spironolactone; Stroke Volume; Surveys and Questionnaires; Ultrasonography; Ventricular Function, Left | 2010 |
The effect of spironolactone upon corticosteroid hormone metabolism in patients with early stage chronic kidney disease.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Female; Humans; Hydrocortisone; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renal Insufficiency, Chronic; Renin; Spironolactone; Tetrahydrocortisol | 2010 |
Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome.
Topics: Adult; Aldosterone; Androgen Antagonists; Androgens; Androstenedione; Dehydroepiandrosterone Sulfate; Endothelial Cells; Female; Humans; Lipids; Lipoproteins, LDL; Polycystic Ovary Syndrome; Potassium; Renin; Spironolactone; Testosterone; Triglycerides; Young Adult | 2011 |
Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction.
Topics: Aldosterone; Biomarkers; Double-Blind Method; Echocardiography; Electrocardiography; Eplerenone; Female; Follow-Up Studies; Heart Ventricles; Humans; Hydrocortisone; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Prospective Studies; Spironolactone; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Remodeling | 2011 |
The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism.
Topics: Adult; Aldosterone; Animals; Area Under Curve; Biomarkers; Cell Line, Tumor; Eplerenone; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium; Spironolactone; Time Factors; Translational Research, Biomedical; Young Adult | 2011 |
Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease.
Topics: Aldosterone; Confidence Intervals; Double-Blind Method; Eplerenone; Female; Health Status Indicators; Heart Failure; Humans; Kidney Failure, Chronic; Male; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Research Design; Severity of Illness Index; Spironolactone | 2012 |
Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans.
Topics: Adolescent; Adult; Aldosterone; Blood Pressure; Cell Movement; Double-Blind Method; Hormones; Humans; Hydrocortisone; L-Selectin; Lymphocyte Count; Male; Mineralocorticoid Receptor Antagonists; Polysomnography; Receptors, CXCR4; Receptors, Mineralocorticoid; Sleep; Sleep Stages; Spironolactone; T-Lymphocytes, Helper-Inducer; Young Adult | 2012 |
Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: a double-blinded, randomized, placebo-controlled crossover trial.
Topics: Aged; Aldosterone; Amiloride; Angiotensin II; Aquaporin 2; Blood Pressure; Cross-Over Studies; Diuretics; Double-Blind Method; Epithelial Sodium Channels; Female; Furosemide; Humans; Hypertension; Kidney Tubules; Male; Middle Aged; Potassium; Pulse Wave Analysis; Renin; Sodium; Spironolactone | 2013 |
Serum free fatty acid levels in PCOS patients treated with glucophage, magnesium oxide and spironolactone.
Topics: Adolescent; Adult; Aldosterone; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Magnesium Oxide; Metformin; Mineralocorticoid Receptor Antagonists; Polycystic Ovary Syndrome; Spironolactone; Young Adult | 2013 |
Effect of aldosterone breakthrough on albuminuria during treatment with a direct renin inhibitor and combined effect with a mineralocorticoid receptor antagonist.
Topics: Aged; Albuminuria; Aldosterone; Amides; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eplerenone; Female; Fumarates; Humans; Hypertension; Incidence; Longitudinal Studies; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone; Time Factors | 2013 |
Eplerenone in systemic right ventricle: double blind randomized clinical trial. The evedes study.
Topics: Adult; Aldosterone; Cardiac Imaging Techniques; Collagen; Double-Blind Method; Eplerenone; Female; Fibrosis; Follow-Up Studies; Heart Failure; Humans; Magnetic Resonance Imaging; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Transposition of Great Vessels; Treatment Outcome; Ventricular Dysfunction, Right; Young Adult | 2013 |
Low dose spironolactone reduces blood pressure in patients with resistant hypertension and type 2 diabetes mellitus: a double blind randomized clinical trial.
Topics: Adult; Aged; Albumins; Aldosterone; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Diabetes Complications; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Spironolactone | 2013 |
Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects.
Topics: Adolescent; Adult; Aldosterone; Blood Pressure; Body Mass Index; Body Weight; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Female; Humans; Insulin Resistance; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Obesity; Spironolactone; Treatment Outcome; Vasodilation | 2014 |
Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Captopril; Diuretics; Dose-Response Relationship, Drug; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Parathyroid Glands; Parathyroid Hormone; Renin-Angiotensin System; Spironolactone; Vasoconstrictor Agents; Vitamin D | 2014 |
Potassium handling with dual renin-angiotensin system inhibition in diabetic nephropathy.
Topics: Adult; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Female; Humans; Hyperkalemia; Lisinopril; Losartan; Male; Middle Aged; Potassium; Prospective Studies; Renin-Angiotensin System; Risk Factors; Sodium; Spironolactone; Texas; Time Factors; Treatment Outcome | 2014 |
A pilot study of the effects of eplerenone add-on therapy in patients taking renin-angiotensin system blockers.
Topics: Adult; Aged; Albuminuria; Aldosterone; Blood Pressure; Diastole; Eplerenone; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Pilot Projects; Renin-Angiotensin System; Spironolactone; Systole | 2015 |
Greater efficacy of aldosterone blockade and diuretic reinforcement vs. dual renin-angiotensin blockade for left ventricular mass regression in patients with resistant hypertension.
Topics: Adolescent; Adult; Aged; Aldosterone; Amiloride; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Bisoprolol; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hypertension; Hypertrophy, Left Ventricular; Irbesartan; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Ramipril; Renin; Renin-Angiotensin System; Spironolactone; Tetrazoles; Young Adult | 2014 |
Effects of spironolactone on dialysis patients with refractory hypertension: a randomized controlled study.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Spironolactone; Treatment Outcome | 2014 |
Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans.
Topics: Adipose Tissue; Aged; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Nucleus; Cytochrome P-450 CYP11B2; Female; Glomerular Filtration Rate; Glucose Tolerance Test; Homeostasis; Humans; Immediate-Early Proteins; Insulin Resistance; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Nephrectomy; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renal Insufficiency, Chronic; Renin; Signal Transduction; Spironolactone | 2015 |
Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial.
Topics: Adult; Aged; Albuminuria; Aldosterone; Asian People; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prospective Studies; Spironolactone; Treatment Outcome | 2015 |
Spironolactone is secure and reduces left ventricular hypertrophy in hemodialysis patients.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Double-Blind Method; Drug Monitoring; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renal Dialysis; Spironolactone; Treatment Outcome | 2015 |
Effect of Treatment on Body Fluid in Patients with Unilateral Aldosterone Producing Adenoma: Adrenalectomy versus Spironolactone.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Aged; Aged, 80 and over; Aldosterone; Body Fluids; Female; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Odds Ratio; Risk Factors; Spironolactone; Treatment Outcome | 2015 |
Effects of continuous positive airway pressure treatment on aldosterone excretion in patients with obstructive sleep apnoea and resistant hypertension: a randomized controlled trial.
Topics: Aged; Aldosterone; Continuous Positive Airway Pressure; Coronary Vasospasm; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; Intention to Treat Analysis; Male; Middle Aged; Obesity; Oxygen; Sleep Apnea, Obstructive; Spironolactone | 2017 |
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Topics: Adult; Aged; Albuminuria; Aldosterone; Animals; Antihypertensive Agents; Diabetic Nephropathies; Female; Humans; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Middle Aged; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Spironolactone | 2017 |
The relation of the serum aldosterone level and central serous chorioretinopathy - a pilot study.
Topics: Adult; Aldosterone; Central Serous Chorioretinopathy; Choroid; Female; Fluorescein Angiography; Humans; Male; Middle Aged; Mineralocorticoids; Pilot Projects; Spironolactone; Tomography, Optical Coherence; Visual Acuity | 2017 |
Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity. Insight from the EMPHASIS-HF trial.
Topics: Aged; Aldosterone; Drug Monitoring; Eplerenone; Female; Heart Failure, Systolic; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Obesity, Abdominal; Spironolactone; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left | 2017 |
Mineralocorticoid Receptor Blockers and Aldosterone to Renin Ratio: A Randomized Controlled Trial and Observational Data.
Topics: Aged; Aldosterone; Double-Blind Method; Eplerenone; Female; Humans; Hyperaldosteronism; Hyperparathyroidism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone; Time Factors | 2018 |
Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial.
Topics: Adult; Aged; Aldosterone; Cardiovascular Diseases; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Echocardiography, Doppler; Feasibility Studies; Female; Gynecomastia; Humans; Hyperkalemia; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Placebos; Potassium; Renal Dialysis; Spironolactone | 2019 |
Spironolactone and perioperative atrial fibrillation occurrence in cardiac surgery patients: Rationale and design of the ALDOCURE trial.
Topics: Adult; Aldosterone; Aortic Valve; Atrial Fibrillation; Coronary Artery Bypass; Double-Blind Method; Female; Heart Valve Prosthesis Implantation; Humans; Male; Mineralocorticoid Receptor Antagonists; Multicenter Studies as Topic; Postoperative Complications; Randomized Controlled Trials as Topic; Spironolactone; Stroke Volume; Time Factors | 2019 |
Effect of spironolactone and benazepril on furosemide-induced diuresis and renin-angiotensin-aldosterone system activation in normal dogs.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Diuresis; Diuretics; Dogs; Furosemide; Male; Renin-Angiotensin System; Spironolactone | 2021 |
Protective effects of spironolactone on vascular calcification in chronic kidney disease.
Topics: Aldosterone; Alkaline Phosphatase; Animals; Aorta; Biomarkers; Cholecalciferol; Core Binding Factor Alpha 1 Subunit; Female; Gene Expression; Humans; Kidney; Mice; Mice, Inbred DBA; Mineralocorticoid Receptor Antagonists; Myocytes, Smooth Muscle; Nephrectomy; Primary Cell Culture; Prospective Studies; Receptors, Mineralocorticoid; Renal Dialysis; Renal Insufficiency, Chronic; Spironolactone; Transcription Factor Pit-1; Vascular Calcification | 2021 |
Efficacy and safety of a low-sodium diet and spironolactone in patients with stage 1-3a chronic kidney disease: a pilot study.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diet, Sodium-Restricted; Female; Humans; Male; Pilot Projects; Renal Insufficiency, Chronic; Sodium; Spironolactone | 2022 |
Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi.
Topics: Aldosterone; Angiotensin II; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Humans; Randomized Controlled Trials as Topic; SARS-CoV-2; Spironolactone; Treatment Outcome; von Willebrand Factor | 2023 |
1290 other study(ies) available for aldosterone and spironolactone
| Article | Year |
|---|---|
Aldosterone antagonists. 1. Synthesis and biological activities of 11 beta,18-epoxypregnane derivatives.
Topics: Animals; Dose-Response Relationship, Drug; Epoxy Compounds; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnanes; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid | 1985 |
Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives.
Topics: Adrenalectomy; Animals; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Mineralocorticoid; Receptors, Progesterone; Receptors, Steroid; Structure-Activity Relationship | 1987 |
A structure-activity relationship study of spirolactones. Contribution of the cyclopropane ring to antimineralocorticoid activity.
Topics: Chemical Phenomena; Chemistry; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Molecular Conformation; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Structure-Activity Relationship | 1981 |
Synthesis of new 11 beta-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors.
Topics: Adrenalectomy; Aldosterone; Animals; Dexamethasone; Kidney; Rabbits; Receptors, Glucocorticoid; Spironolactone; Structure-Activity Relationship | 1993 |
Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates.
Topics: Anion Transport Proteins; Anions; Carrier Proteins; HeLa Cells; Hormones; Humans; Hydrogen-Ion Concentration; Serum Albumin; Sodium Chloride; Solutions; Steroids; Substrate Specificity; Sucrose; Sulfobromophthalein; Taurocholic Acid; Time Factors | 1996 |
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
Topics: Benzhydryl Compounds; Binding Sites; Diethylstilbestrol; Endocrine System; Hydrocarbons, Chlorinated; Ligands; Models, Molecular; Molecular Conformation; Phenols; Phytoestrogens; Quantitative Structure-Activity Relationship; Receptors, Androgen; Testosterone; Thermodynamics; Xenobiotics | 2005 |
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity | 2009 |
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
Topics: Animals; Chlorocebus aethiops; Female; Humans; Hypocreales; Indoles; Luciferases; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Progestins; Receptors, Progesterone; Sesquiterpenes | 2009 |
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Topics: Amino Acid Sequence; Animals; Benzoxazines; Dihydropyridines; Drug Discovery; Humans; Ligands; Macrolides; Mineralocorticoid Receptor Antagonists; Models, Molecular; Oxazolidinones; Peptides; Pyrazoles; Pyrroles; Receptors, Mineralocorticoid; Structure-Activity Relationship; Sulfonamides | 2017 |
Studies on rat renal cortical cell kallikrein. I. Separation and measurement.
Topics: Aldosterone; Animals; Biological Assay; Hydrogen-Ion Concentration; Immunodiffusion; Kallikreins; Kidney; Kidney Cortex; Kinetics; Male; Organ Specificity; Rats; Spironolactone | 1975 |
Diuretic-induced oedema.
Topics: Adult; Aldosterone; Blood Volume; Body Weight; Chlorthalidone; Diuretics; Edema; Female; Furosemide; Humans; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Water-Electrolyte Balance | 1975 |
Severe arterial hypertension caused by chronical abuse of a topical mineralocorticoid.
Topics: Adult; Aldosterone; Clonidine; Drug Combinations; Drug Therapy, Combination; Female; Fluprednisolone; Humans; Hypertension; Isomerism; Methyldopa; Naphazoline; Nasal Decongestants; Potassium; Renin; Spironolactone; Substance-Related Disorders; Time Factors; Triamterene | 1975 |
Effect of adrenal steroids on vasopressin-stimulated PGE synthesis and water flow.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Arachidonic Acids; Arginine Vasopressin; Body Water; Bufo marinus; Cycloheximide; Dactinomycin; Dexamethasone; In Vitro Techniques; Progesterone; Prostaglandins E; Sodium; Spironolactone; Triamcinolone; Urinary Bladder; Vasopressins | 1978 |
[Cytochrome P-450 and transformation from 18-hydroxycorticosterone to aldosterone].
Topics: 18-Hydroxycorticosterone; Adrenal Glands; Aldosterone; Animals; Corticosterone; Cytochrome P-450 Enzyme System; Ducks; In Vitro Techniques; Male; Metyrapone; Mitochondria; Oxidation-Reduction; Spironolactone | 1979 |
The Distinguished Lecture. Is hypertension essential?
Topics: Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Dehydroepiandrosterone; Humans; Hypertension; Hypertension, Renal; Mineralocorticoids; Natriuresis; Norepinephrine; Patient Compliance; Phenoxybenzamine; Renal Artery Obstruction; Renin; Saralasin; Spironolactone | 1975 |
Hypertension, hypokalemia, hyporeninemia and severe target organ damage.
Topics: Aldosterone; Blood Pressure; Cardiomegaly; Female; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Middle Aged; Potassium; Renal Artery Obstruction; Renin; Retinal Hemorrhage; Spironolactone | 1976 |
Effects of aldosterone and spironolactone on renal ATPase activities [proceedings].
Topics: Adenosine Triphosphatases; Aldosterone; Animals; Enzyme Activation; In Vitro Techniques; Kidney; Rats; Spironolactone | 1978 |
[Plasma-aldosterone and renin activity in Bartter's syndrome (author's transl)].
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Bartter Syndrome; Dexamethasone; Glucocorticoids; Humans; Hyperaldosteronism; Male; Potassium; Renin; Sodium; Spironolactone; Time Factors | 1975 |
Corticoid receptors in rat brain: evidence for an aldosterone receptor.
Topics: Aldosterone; Animals; Binding Sites; Brain; Corticosterone; Cytosol; Dexamethasone; Macromolecular Substances; Male; Rats; Receptors, Cell Surface; Spironolactone | 1976 |
Agonist and antimineralocorticoid activities of spirolactones.
Topics: Aldosterone; Animals; Binding, Competitive; Biological Transport, Active; Bufo marinus; Mineralocorticoid Receptor Antagonists; Receptors, Cell Surface; Sodium; Spironolactone; Urinary Bladder | 1976 |
[Aldosterone and active sodium transport].
Topics: Aldosterone; Binding, Competitive; Biological Transport, Active; Cell Nucleus; Humans; Membrane Transport Proteins; Mineralocorticoid Receptor Antagonists; Models, Biological; Protein Binding; Receptors, Cell Surface; Sodium; Spironolactone | 1977 |
Oxidative response to aldosterone of pyridine nucleotide in rat kidney in situ.
Topics: Adenine Nucleotides; Aldosterone; Animals; Calcitonin; Cycloheximide; Dactinomycin; Desoxycorticosterone; Dexamethasone; Dinitrophenols; Dose-Response Relationship, Drug; Energy Metabolism; Glycyrrhetinic Acid; Hemorrhage; Kidney; Male; Malonates; NAD; Ouabain; Oxidation-Reduction; Pyruvates; Rats; Rotenone; Spironolactone; Water | 1977 |
Spironolactone antagonism of aldosterone action on Na+ transport and RNA metabolism in toad bladder epithelium.
Topics: Aldosterone; Animals; Binding, Competitive; Biological Transport; Epithelium; Mineralocorticoid Receptor Antagonists; Poly A; Receptors, Cell Surface; RNA; Sodium; Spironolactone; Urinary Bladder | 1977 |
The effect of corticosteroids on alveolar macrophage activity.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aerosols; Aldosterone; Animals; Biological Transport; Desoxycorticosterone; Hydrocortisone; Iron; Macrophages; Male; Metyrapone; Pulmonary Alveoli; Rats; Spironolactone; Triamcinolone Acetonide | 1977 |
Plasma concentration of aldosterone, 18-hydroxy-deoxycorticosterone and cortisol in adrenal veins of patients with low-renin hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Renin; Spironolactone; Veins | 1977 |
Control of plasma aldosterone in a patient with Conn's syndrome before and during spironolactone medication.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Female; Humans; Hydrocortisone; Hyperaldosteronism; Middle Aged; Renin; Secretory Rate; Spironolactone | 1975 |
Occupancy of aldosterone binding sites in rat kidney cytosol.
Topics: Adrenalectomy; Aldosterone; Animals; Calcium; Cytosol; Edetic Acid; In Vitro Techniques; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Cell Surface; Spironolactone; Temperature | 1978 |
Glucocorticoid regulation of prolactin receptors in kidneys and adrenals of male rats.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Dexamethasone; Hydrocortisone; Hypophysectomy; Kidney; Kinetics; Male; Prolactin; Rats; Receptors, Cell Surface; Spironolactone | 1978 |
Loci of action of regulators of aldosterone biosynthesis in isolated glomerulosa cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Corticosterone; Desoxycorticosterone; Dogs; In Vitro Techniques; Potassium; Progesterone; Rats; Spironolactone | 1979 |
Comparison of the urinary excretion of free aldosterone and its acid-labile conjugate in rats during experimental hyperaldosteronism.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Hyperaldosteronism; Male; Potassium; Radioimmunoassay; Rats; Sodium; Spironolactone | 1979 |
Reduced response of plasma aldosterone to acute ACTH stimulation during long-term treatment with spironolactone in essential hypertension.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Blood Pressure; Humans; Hydrochlorothiazide; Hydrocortisone; Hypertension; Middle Aged; Potassium; Renin; Sodium; Spironolactone | 1979 |
SC 25152: A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat prostate.
Topics: Aldosterone; Animals; Dihydrotestosterone; Humans; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Prostate; Rats; Receptors, Androgen; Receptors, Steroid; Species Specificity; Spironolactone | 1978 |
Ultrastructural evidence for aldosterone- and corticosterone-secreting cells in the adrenocortical tissue of the American Bullfrog (Rana catesbeiana).
Topics: Adrenal Glands; Aldosterone; Animals; Anura; Corticosterone; Dexamethasone; Hypophysectomy; Rana catesbeiana; Sodium; Spironolactone | 1977 |
Pathophysiological studies on hypertension induced in rats by kidney extract and salt.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Aldosterone; Angiotensin II; Animals; Blood Pressure; Blood Volume; Body Fluids; Hexamethonium Compounds; Hypertension; Kidney; Male; Nephrectomy; Norepinephrine; Rats; Renin; Sodium Chloride; Spironolactone; Tissue Extracts; Water-Electrolyte Balance | 1979 |
The role of renal prostaglandin E and kallikrein in pathogenesis of essential hypertension.
Topics: Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hypertension; Indomethacin; Kallikreins; Kidney; Male; Middle Aged; Posture; Potassium; Prostaglandins E; Renin; Sodium; Spironolactone | 1979 |
Aldosterone antagonism studies in the rhesus monkey.
Topics: Administration, Oral; Aldosterone; Animals; Canrenone; Diuresis; Dose-Response Relationship, Drug; Female; Haplorhini; Hydrochlorothiazide; Injections, Intramuscular; Macaca mulatta; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone | 1977 |
Value of the spironolactone test in the diagnosis of primary hyperaldosteronism.
Topics: Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Sodium; Sodium Chloride; Spironolactone | 1979 |
[Disorder of the mineralocorticoid function of the adrenals in the acute period of myocardial infarct and the ways for its correction].
Topics: Acute Disease; Adrenal Gland Diseases; Adult; Aged; Aldosterone; Chronic Disease; Coronary Disease; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoids; Myocardial Infarction; Spironolactone; Tachycardia, Paroxysmal | 1979 |
Mechanism of action of a new antialdosterone compound, prorenone.
Topics: Aldosterone; Animals; Binding, Competitive; Cell Nucleus; Dexamethasone; Dihydrotestosterone; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Prostate; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Spironolactone | 1979 |
A comparison of some extra-renal effects of spironolactone and canrenone.
Topics: Aldosterone; Canrenone; Humans; Male; Membrane Potentials; Middle Aged; Mineralocorticoid Receptor Antagonists; Pregnadienes; Pressure; Rectum; Spironolactone; Time Factors | 1979 |
The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aldosterone; Corticosterone; Humans; Hyperaldosteronism; Posture; Potassium; Potassium Chloride; Renin; Spironolactone | 1979 |
[Therapy of primary hyperaldosteronism].
Topics: Adrenalectomy; Aldosterone; Androgen Antagonists; Angiotensin II; Estrogen Antagonists; Female; Humans; Hyperaldosteronism; Male; Renin; Spironolactone | 1979 |
Role of renal prostaglandins and relationship to renin, aldosterone, and antidiuretic hormone during salt depletion in man.
Topics: Adult; Aged; Aldosterone; Arginine Vasopressin; Arthritis, Rheumatoid; Diet, Sodium-Restricted; Female; Humans; Indomethacin; Male; Middle Aged; Prostaglandins E; Prostaglandins F; Renin; Spironolactone | 1979 |
Effect of spironolactone treatment on the renin-aldosterone system during pregnancy.
Topics: Aldosterone; Canrenone; Female; Humans; Potassium; Pregnancy; Renin; Sodium; Spironolactone; Time Factors | 1979 |
[Plasma aldosterone and electrolytes in primary and secondard aldosteronism (author's transl)].
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Ascites; Electrolytes; Female; Humans; Hyperaldosteronism; Liver Cirrhosis; Magnesium; Male; Potassium; Sodium; Spironolactone | 1979 |
Comparative effects of canrenoate-K and prorenoate-K upon aldosterone biosynthesis in perifused frog interrenal glands.
Topics: Adrenal Glands; Aldosterone; Animals; Anura; Canrenoic Acid; Interrenal Gland; Mineralocorticoid Receptor Antagonists; Pregnadienes; Radioimmunoassay; Ranidae; Spironolactone; Time Factors | 1979 |
Renal kallikrein-kinin system and prostaglandin in hypertension: their relation to renin-angiotensin-aldosterone system.
Topics: Adolescent; Adult; Aged; Aldosterone; Angiotensins; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hypertension; Indomethacin; Kallikreins; Kidney; Male; Middle Aged; Prostaglandins E; Renin; Spironolactone | 1979 |
Haemodynamic effects of treatment and withdrawal of spironolactone in essential hypertension.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Body Weight; Cardiac Output; Creatinine; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Plasma Volume; Radioisotope Renography; Renin; Spironolactone | 1979 |
Effect of triamterene on urinary excretion of immunoreactive prostaglandin E in essential hypertension.
Topics: Adolescent; Adult; Aldosterone; Angiotensins; Blood Pressure; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium; Prostaglandins E; Radioimmunoassay; Renin; Sodium; Spironolactone; Time Factors; Triamterene | 1979 |
[Low renin hypertension and aldosterone].
Topics: Adolescent; Adult; Aldosterone; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone | 1977 |
Improved method for comparative evaluation of aldosterone antagonists in healthy man.
Topics: Adult; Aldosterone; Canrenoic Acid; Drug Evaluation; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Time Factors | 1977 |
Interaction between aldosterone and renomedullary prostaglandins. Competitive action between aspirin and spironolactone.
Topics: Adrenalectomy; Aldosterone; Animals; Aspirin; Male; Potassium; Prostaglandins A, Synthetic; Prostaglandins E; Rats; Sodium; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Aldosterone; Altitude Sickness; Humans; Hypoxia; Spironolactone | 1977 |
Drug-induced variations of the renin-angiotensin-aldosterone system in rats. I. Diuretics.
Topics: Aldosterone; Angiotensin II; Animals; Diuresis; Diuretics; Male; Potassium; Rats; Renin; Sodium; Spironolactone; Triamterene | 1977 |
[Modern pathophysiological aspects regarding the treatment of brain edema (author's transl)].
Topics: Aldosterone; Brain Abscess; Brain Edema; Brain Injuries; Brain Neoplasms; Cerebral Ventricles; Dexamethasone; Diuretics; Drainage; Encephalitis; Glucocorticoids; Hypertonic Solutions; Plasma Substitutes; Respiration, Artificial; Spironolactone | 1978 |
Aldosterone in the exaggerated natriuresis of spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Body Water; Diet; Extracellular Space; Hypertension; Kidney; Male; Natriuresis; Rats; Sodium Chloride; Spironolactone | 1978 |
[EEG changes following spirolactone treatment (author's transl)].
Topics: Aldosterone; Brain Edema; Canrenoic Acid; Electroencephalography; Encephalitis; Female; Humans; Male; Multiple Sclerosis; Spironolactone | 1978 |
Comparison of the antihypertensive and hormonal effects of a cardioselective beta-blocker, acebutolol, and diuretics in essential hypertension.
Topics: Acebutolol; Adult; Aldosterone; Amiloride; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renin; Spironolactone | 1978 |
Congenital pseudohypoaldosteronism: case report and review. Effect of indomethacin during sodium chloride depletion.
Topics: Adrenal Insufficiency; Aldosterone; Body Weight; Chlorides; Desoxycorticosterone; Diagnosis, Differential; Diet; Humans; Indomethacin; Infant, Newborn; Male; Potassium; Renin; Sodium; Sodium Chloride; Spironolactone | 1978 |
Spironolactone. An aldosterone agonist in the stimulation of H+ secretion by turtle urinary bladder.
Topics: Aldosterone; Animals; Hydrogen; In Vitro Techniques; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Sodium; Spironolactone; Turtles; Urinary Bladder | 1978 |
Effect of aldosterone on incorporation of amino acids into renal medullary proteins.
Topics: Adrenalectomy; Aldosterone; Amino Acids; Animals; Calcium; Cytosol; Dactinomycin; Dexamethasone; Kidney; Kidney Medulla; Leucine; Male; Methionine; Mineralocorticoid Receptor Antagonists; Proteins; Rats; RNA; Sodium; Spironolactone | 1978 |
[Bartter's syndrome. Current prospects of nosographic classification and new therapeutic possibilities].
Topics: Aldosterone; Bartter Syndrome; Child; Electrolytes; Female; Humans; Hyperaldosteronism; Indomethacin; Potassium; Prostaglandins; Renin; Sodium Chloride; Spironolactone | 1978 |
[Measurement of plasma aldosterone by 125I-aldosterone radioimmunoassay kit (author's transl)].
Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Humans; Radioimmunoassay; Rats; Reagent Kits, Diagnostic; Spironolactone | 1978 |
Subpressor angiotensin infusion, renal sodium handling, and salt-induced hypertension in the dog.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Furosemide; Hypertension; Infusions, Parenteral; Natriuresis; Renin; Sodium Chloride; Spironolactone; Time Factors | 1978 |
Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Electrolytes; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Renin; Spironolactone | 1978 |
[Long-term minoxidil therapy: renin, aldosterone, noradrenaline and the need for beta blockers].
Topics: Adult; Aldosterone; Chlorthalidone; Female; Furosemide; Hirsutism; Humans; Hypertension; Male; Middle Aged; Minoxidil; Norepinephrine; Oxprenolol; Propranolol; Pyrimidines; Renin; Spironolactone; Water-Electrolyte Balance | 1978 |
Role of aldosterone in the control of sodium excretion in patients with advanced chronic renal failure.
Topics: Adult; Aldosterone; Body Weight; Creatinine; Diet; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Posture; Potassium; Sodium; Spironolactone | 1978 |
[Study on potassium transport in the intestine compensatory potassium excretion mechanism increasing factors of potassium secretion (author's transl)].
Topics: Aldosterone; Animals; Biological Transport; Humans; Intestinal Mucosa; Kidney Diseases; Male; Postural Balance; Potassium; Rats; Sodium; Spironolactone | 1978 |
[Effect of spironolactones on aldosterone synthesis and adrenal metabolism].
Topics: Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Ducks; Hydroxylation; Mineralocorticoid Receptor Antagonists; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Sheep; Spironolactone; Steroid Hydroxylases | 1978 |
The effect of spironolactone on the hepatic metabolism of aldosterone in male rats.
Topics: Aldosterone; Animals; Bile; Chromatography, Ion Exchange; Liver; Male; Rats; Spironolactone | 1978 |
Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Animals; Canrenone; Dose-Response Relationship, Drug; Male; Pregnadienes; Rats; Renin; Spironolactone; Time Factors; Water-Electrolyte Balance | 1979 |
Effects of aldosterone and potassium-sparing diuretics on electrical potential differences across the distal nephron.
Topics: Adrenalectomy; Aldosterone; Animals; Biological Transport; Female; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Distal; Membrane Potentials; Rabbits; Sodium; Spironolactone; Temperature; Triamterene | 1977 |
Diagnosis, localization, and treatment of primary aldosteronism.
Topics: Aldosterone; Antihypertensive Agents; Catheterization; Diagnosis, Differential; Humans; Hyperaldosteronism; Radionuclide Imaging; Renin; Spironolactone | 1977 |
Physiological activity and receptor binding of 9 alpha fluorohydrocortisone.
Topics: Aldosterone; Animals; Binding, Competitive; Corticosterone; Fludrocortisone; Gluconeogenesis; Hydrocortisone; Kidney; Liver; Male; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Spironolactone; Triamcinolone Acetonide | 1977 |
[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism].
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Adult; Aldosterone; Blood Pressure; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Posture; Potassium; Renin; Sodium; Sodium Chloride; Spironolactone | 1977 |
Aldosterone and postprandial renal excretion of sodium and potassium in sheep.
Topics: Aldosterone; Animals; Feeding Behavior; Female; Kidney; Natriuresis; Potassium; Sheep; Spironolactone | 1977 |
Potassium-sparing diuretics.
Topics: Aldosterone; Amiloride; Animals; Chlorides; Diuretics; Dogs; Dose-Response Relationship, Drug; Humans; Imidazoles; Kidney; Mineralocorticoid Receptor Antagonists; Natriuresis; Potassium; Rats; Spironolactone; Triamterene | 1977 |
The renin-angiotensin system in hypertension.
Topics: Aldosterone; Angiotensins; Diuretics; Humans; Hypertension; Juxtaglomerular Apparatus; Propranolol; Renin; Spironolactone | 1977 |
Spironolactone-induced inhibition of aldosterone biosynthesis in primary aldosteronism: morphological and functional studies.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aldosterone; Humans; Hyperaldosteronism; Spironolactone | 1977 |
[Aldosterone and renin in liver cirrhosis with ascites].
Topics: Aldosterone; Ascites; Furosemide; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Renin; Spironolactone | 1977 |
Factors influencing the choice of antihypertensive agents.
Topics: Age Factors; Aldosterone; Cerebrovascular Disorders; Clonidine; Depression; Diabetes Complications; Female; Gout; Guanethidine; Heart Diseases; Humans; Hypertension; Male; Occupations; Sex Factors; Spironolactone | 1976 |
Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.
Topics: Adult; Aged; Aldosterone; Amiloride; Angiotensin II; Digoxin; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Urea | 1976 |
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Animals; Canrenoic Acid; Canrenone; Cattle; Cytochrome P-450 Enzyme System; Humans; Hyperplasia; Mitochondria; Oxidation-Reduction; Pregnadienes; Spectrum Analysis; Spironolactone; Steroid Hydroxylases | 1976 |
[Effect of aldosterone and aldactone on the cornea].
Topics: Aldosterone; Animals; Cornea; Rabbits; Spironolactone | 1976 |
[Hormonal disturbances and the treatment of refractory forms of congestive circulatory insufficiency].
Topics: Aldosterone; Body Water; Circadian Rhythm; Diuresis; Drug Therapy, Combination; Furosemide; Glucocorticoids; Heart Failure; Humans; Prednisolone; Spironolactone; Water-Electrolyte Balance | 1976 |
[Prospects of medical treatment in communicating congenital hydrocephalus].
Topics: Acetazolamide; Aldosterone; Humans; Hydrocephalus; Infant; Ouabain; Spironolactone; Vasopressins | 1976 |
[Evaluation of the plasma renin activity and urinary aldosterone excretion in patients with essential hypertension treated with spironolactone. Note II].
Topics: Adult; Aldosterone; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone | 1976 |
[Rectal electrical potential difference and plasma aldosterone in hyperaldosteronism and low-, normal- and high-renin hypertension].
Topics: Action Potentials; Adult; Aged; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Rectum; Renin; Spironolactone | 1976 |
[Endogenous steroid balance under treatment with spironolactone].
Topics: Aldosterone; Angiotensin II; Humans; Male; Renin; Spironolactone | 1976 |
Effects of aldosterone and spironolactone on arterial renin in rats.
Topics: Aldosterone; Animals; Aorta; Hypertension; Male; Rats; Renin; Spironolactone; Subcellular Fractions | 1976 |
The effects of aldosterone and spironolactone on renal kallikrein in the rat.
Topics: Aldosterone; Animals; Cell Count; Enzyme Induction; In Vitro Techniques; Kallikreins; Kidney Cortex; Male; Rats; Spironolactone | 1976 |
Stimulation by aldosterone of the sodium efflux in barnacle muscle fibres: effects of RNA inhibitors and spironolactone.
Topics: Aldosterone; Amanitins; Animals; Biological Transport; Dactinomycin; Deoxyadenosines; Dose-Response Relationship, Drug; In Vitro Techniques; Muscles; Sodium; Spironolactone; Thoracica | 1975 |
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencephalography; Epilepsy; Female; Male; Phenytoin; Spironolactone | 1975 |
[Letter: Spironolactone and aldosterone in brain edema].
Topics: Aldosterone; Brain Edema; Humans; Spironolactone | 1975 |
[Edematous hepatitis: a special form of acute virus hepatitis with secondary aldosteronism (author's transl)].
Topics: Adult; Aldosterone; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Edema; Female; Hepatitis A; Hepatitis B Antigens; Humans; Hyperaldosteronism; Liver; Liver Circulation; Liver Diseases; Potassium; Spironolactone; Water-Electrolyte Balance | 1975 |
Proceedings: Acute and chronic effects of the aldosterone antagonist spironolactone and its main metabolite canrenone on plasma aldosterone concentration, plasma renin activity, serum electrolytes and on the excretion of aldosterone, fluid and electrolyte
Topics: Aldosterone; Animals; Canrenone; Electrolytes; Male; Pregnadienes; Rats; Renin; Spironolactone | 1975 |
Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite.
Topics: Aldosterone; Animals; Canrenoic Acid; Cross Reactions; Dogs; Humans; Mass Spectrometry; Pregnadienes; Rabbits; Radioimmunoassay; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spironolactone; Time Factors | 1975 |
[Use of aldactone-saltucine in patients with heart failure].
Topics: Adult; Aged; Aldosterone; Body Weight; Butanes; Chlorides; Diuretics; Drug Combinations; Drug Evaluation; Heart Failure; Humans; Hydrochlorothiazide; Middle Aged; Natriuresis; Potassium; Sodium; Spironolactone | 1975 |
Bartter's syndrome. New insights into pathogenesis and treatment.
Topics: Adult; Aldosterone; Angiotensin II; Bartter Syndrome; Blood Volume; Female; Humans; Hyperaldosteronism; Kidney; Kidney Concentrating Ability; Potassium Chloride; Pressoreceptors; Propranolol; Renin; Sodium; Spironolactone | 1975 |
[Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)].
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Body Weight; Butanes; Female; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Natriuresis; Placebos; Potassium; Pregnancy; Renin; Sodium; Spironolactone; Time Factors | 1975 |
Renal function and diuretic therapy in infants and children. Part II.
Topics: Acetazolamide; Aldosterone; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Child; Diuretics; Diuretics, Osmotic; Ethacrynic Acid; Female; Fetus; Furosemide; Humans; Infant; Kidney; Kidney Glomerulus; Kidney Tubules; Organomercury Compounds; Pediatrics; Potassium; Pregnancy; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene; Water-Electrolyte Balance | 1975 |
[Role of aldosterone in the initial stage of 2 forms of experimental vasorenal hypertension].
Topics: Aldosterone; Animals; Blood Pressure; Hypertension, Renal; Ischemia; Kidney; Ligation; Male; Mineralocorticoid Receptor Antagonists; Rats; Renal Artery; Sodium; Spironolactone; Time Factors | 1975 |
Low renin essential hypertension in a child.
Topics: Aldosterone; Child; Circadian Rhythm; Dexamethasone; Humans; Hydrochlorothiazide; Hydrocortisone; Hypertension; Male; Renin; Spironolactone | 1976 |
Mode of stimulation by aldosterone of the sodium efflux in barnacle muscle fibres: effects of ouabain, ethacrynic acid, diphenylhydantoin, (ATPMg)(2-), adenine translocase inhibitors, pyruvate and oxythiamine.
Topics: Adenosine Triphosphate; Aldosterone; Animals; Atractyloside; Biological Transport, Active; Bongkrekic Acid; Dactinomycin; Ethacrynic Acid; In Vitro Techniques; Muscles; Ouabain; Oxythiamine; Phenytoin; Phosphatidylserines; Pyruvates; Sodium; Spironolactone; Stimulation, Chemical | 1976 |
Determinants of deranged sodium and water homeostasis in decompensated cirrhosis.
Topics: Adult; Aldosterone; Body Weight; Creatinine; Desoxycorticosterone; Diet; Homeostasis; Humans; Immersion; Liver Cirrhosis; Middle Aged; Natriuresis; Osmolar Concentration; Potassium; Sodium; Spironolactone; Water-Electrolyte Imbalance | 1976 |
[Diagnosis and treatment of primary aldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hyperkalemia; Male; Middle Aged; Renin; Spironolactone | 1992 |
Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Aldosterone; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypokalemia; Magnetic Resonance Imaging; Renin; Spironolactone | 1992 |
Aldosterone antagonists destabilize the mineralocorticosteroid receptor.
Topics: Aldosterone; Animals; Binding Sites; Chickens; Heat-Shock Proteins; In Vitro Techniques; Kinetics; Mineralocorticoid Receptor Antagonists; Progesterone; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1992 |
Aldosterone does not alter apical cell-surface expression of epithelial Na+ channels in the amphibian cell line A6.
Topics: Aldosterone; Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Epithelium; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Membrane Proteins; Methionine; Molecular Weight; Sodium Channels; Spironolactone; Sulfur Radioisotopes; Xenopus laevis | 1992 |
The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27.
Topics: 18-Hydroxycorticosterone; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Animals, Genetically Modified; Corticosterone; Desoxycorticosterone; Enzyme Precursors; Gene Expression; Hypertension; Rats; Rats, Inbred Strains; Renin; Spironolactone | 1992 |
Mineralocorticoid hormone action in plant cells.
Topics: Aldosterone; Animals; Chlamydomonas reinhardtii; Chromatography, Ion Exchange; Cytosol; DNA-Binding Proteins; Immunoglobulin G; Molecular Weight; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1992 |
Efficacy of low-dose captopril in addition to furosemide and spironolactone in patients with decompensated liver disease during blunted diuresis.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Captopril; Creatinine; Cyclic GMP; Diuresis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Humans; Kidney; Liver; Liver Cirrhosis; Male; Middle Aged; Renal Dialysis; Renin; Sodium; Spironolactone | 1992 |
Central tachykinin injection potently suppresses the need-free salt intake of the female rat.
Topics: Aldosterone; Angiotensin II; Animals; Captopril; Down-Regulation; Drinking; Eating; Eledoisin; Female; Injections, Intraperitoneal; Injections, Intraventricular; Kassinin; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium, Dietary; Spironolactone; Sucrose; Tachykinins | 1992 |
Glucocorticoids inhibit colonic aldosterone-induced conductive Na+ absorption in adrenalectomized rat.
Topics: Absorption; Adrenalectomy; Aldosterone; Androstanols; Animals; Biological Transport; Carrier Proteins; Colon; Dexamethasone; Male; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Sodium-Hydrogen Exchangers; Spironolactone | 1992 |
[The age-related characteristics of the hormonal regulation of Na+, K(+)-ATPase activity in the kidney cortex of rats].
Topics: Adrenalectomy; Aging; Aldosterone; Animals; Kidney Cortex; Kidney Tubules, Collecting; Kidney Tubules, Distal; Male; Mifepristone; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1992 |
Reactive and reparative myocardial fibrosis in arterial hypertension in the rat.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomegaly; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Renovascular; Male; Myocardium; Rats; Rats, Sprague-Dawley; Sodium, Dietary; Spironolactone | 1992 |
Dexamethasone and aldosterone modulate corticotropin-releasing factor-41 release from cultured rat fetal hypothalamic cells through type II and type I corticosteroid receptors respectively.
Topics: Aldosterone; Animals; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Fetus; Hypothalamus; Mifepristone; Mineralocorticoid Receptor Antagonists; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Spironolactone | 1992 |
Aldosterone reduces baroreceptor discharge in the dog.
Topics: Aldosterone; Animals; Blood Pressure; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; Heart Failure; Male; Ouabain; Pressoreceptors; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 1992 |
Dietary restriction sensitizes the rat distal colon to aldosterone.
Topics: Adrenalectomy; Aldosterone; Amiloride; Animals; Biological Transport; Colon; Corticosterone; Food Deprivation; Intestinal Absorption; Rats; Sodium; Spironolactone; Starvation | 1992 |
Transformation and nuclear translocation of brain type L corticosteroid receptors complexed with the mineralocorticoid antagonist ZK 91587, aldosterone or dexamethasone.
Topics: Aldosterone; Amygdala; Animals; Cell Nucleus; Cellulose; Culture Techniques; Dexamethasone; DNA; Hippocampus; Male; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Spironolactone | 1992 |
Renal action of progesterone and 18-substituted derivatives.
Topics: Aldosterone; Animals; Kidney; Kidney Tubules, Collecting; Male; Progesterone; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1991 |
The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type I) antagonist RU28318.
Topics: Adrenalectomy; Aldosterone; Animals; Carbenoxolone; Corticosterone; Creatinine; Desoxycorticosterone; Male; Mineralocorticoids; Natriuresis; Potassium; Rats; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1991 |
[The hormonal regulation of mRNA Na,K-ATPase expression in rat kidneys in postnatal ontogeny].
Topics: Adrenalectomy; Aging; Aldosterone; Animals; Dexamethasone; Enzyme Induction; Gene Expression Regulation, Enzymologic; Kidney Cortex; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1991 |
Renin gene expression in the adrenal and kidney of patients with primary aldosteronism.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Carcinoma, Renal Cell; Gene Expression; Humans; Hyperaldosteronism; Kidney; Kidney Neoplasms; Reference Values; Renin; RNA, Messenger; Spironolactone | 1992 |
A neonate with idiopathic hyperaldosteronism.
Topics: Aldosterone; Calcium; Gastrointestinal Diseases; Humans; Hyperaldosteronism; Hypokalemia; Infant, Newborn; Magnesium Hydroxide; Male; Nifedipine; Renin-Angiotensin System; Spironolactone | 1991 |
Effect of chronic treatment with clonidine and spironolactone on cold-induced elevation of blood pressure.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Body Weight; Clonidine; Cold Temperature; Drinking; Drug Therapy, Combination; Eating; Epinephrine; Hypertension; Kidney; Male; Norepinephrine; Organ Size; Rats; Rats, Inbred Strains; Renin; Spironolactone; Time Factors; Urination | 1991 |
Inhibitory effects of the novel anti-aldosterone compound mespirenone on adrenocortical steroidogenesis in vitro.
Topics: Adrenal Cortex; Aldosterone; Androgens; Animals; Cross Reactions; Depression, Chemical; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Radioimmunoassay; Rats; Rats, Inbred Strains; Spironolactone | 1991 |
Interference of C17-spirosteroids with late steps of aldosterone biosynthesis. Structure-activity studies.
Topics: 17-alpha-Hydroxyprogesterone; 18-Hydroxycorticosterone; Aldosterone; Animals; Corticosterone; Depression, Chemical; Hydroxyprogesterones; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Spironolactone; Structure-Activity Relationship | 1991 |
Aldosterone in congestive heart failure: analysis of determinants and role in sodium retention.
Topics: Aldosterone; Atrial Natriuretic Factor; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Potassium; Renin-Angiotensin System; Sodium; Sodium, Dietary; Spironolactone | 1991 |
A pathophysiological interpretation of unresponsiveness to spironolactone in a stepped-care approach to the diuretic treatment of ascites in nonazotemic cirrhotic patients.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Ascites; Diuretics; Drug Resistance; Electrolytes; Female; Humans; Lithium; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Renin; Spironolactone | 1991 |
Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactones.
Topics: Adrenalectomy; Aldosterone; Animals; Chemical Phenomena; Chemistry; Endometrium; Female; Male; Mineralocorticoid Receptor Antagonists; Molecular Structure; Potassium; Pregnancy; Pregnancy Maintenance; Rabbits; Rats; Rats, Inbred Strains; Receptors, Progesterone; Sodium; Spironolactone | 1991 |
[In vitro functional differentiation of hippocampal corticosterone receptors by mineralo- and glucocorticoids].
Topics: Aldosterone; Animals; Corticosterone; Evoked Potentials; Hippocampus; Mice; Mice, Inbred BALB C; Receptors, Steroid; Spironolactone | 1991 |
[Abnormal production of adrenal gland hormones--special reference to mineralocorticoids].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Calcium Channel Blockers; Dexamethasone; Female; Humans; Hyperaldosteronism; Hyperkalemia; Hypoaldosteronism; Japan; Male; Middle Aged; Reference Standards; Spironolactone | 1991 |
Potentiation by aldosterone of vasopressin-induced calcium kinetics in vascular smooth muscle cells.
Topics: Aldosterone; Animals; Aorta, Thoracic; Arginine Vasopressin; Calcium; Cells, Cultured; Cytosol; Drug Synergism; Fura-2; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Spironolactone | 1991 |
Autoradiographic evidence of nuclear binding of spironolactone in rabbit cortical collecting tubule.
Topics: Aldosterone; Animals; Autoradiography; Cell Nucleus; Cytoplasm; Female; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Rabbits; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Tritium | 1991 |
Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Reference Values; Spironolactone | 1991 |
Jejunal permeability to water and electrolytes in patients with chronic intrahepatic hypertension: evidence for a role of aldosterone.
Topics: Adult; Aged; Aldosterone; Chlorides; Electrolytes; Female; Humans; Hypertension, Portal; Intestinal Absorption; Jejunum; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Potassium; Sodium; Spironolactone; Water | 1991 |
The influence of endogenous mineralocorticoids on the composition of fetal urine.
Topics: Aldosterone; Amiloride; Animals; Chlorides; Female; Fetus; Glomerular Filtration Rate; Mineralocorticoids; Potassium; Pregnancy; Sheep; Sodium; Spironolactone; Urine | 1990 |
Pseudohyperaldosteronism from liquorice-containing laxatives.
Topics: Adult; Aged; Aldosterone; Cathartics; Drug Combinations; Female; Glycyrrhiza; Humans; Hyperaldosteronism; Male; Middle Aged; Plant Extracts; Plant Oils; Plants, Medicinal; Potassium; Renin; Senna Extract; Spironolactone | 1990 |
Purification and characterization of the activated mineralocorticoid receptor from rat myocardium.
Topics: Aldosterone; Animals; Cellulose; Chromatography; Cytosol; DNA; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Magnesium Chloride; Male; Molecular Weight; Myocardium; Potassium Chloride; Promegestone; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1990 |
Properties and distribution of binding sites for the mineralocorticoid receptor antagonist [3H]ZK 91587 in brain.
Topics: Adrenalectomy; Aldosterone; Amygdala; Animals; Binding, Competitive; Brain; Corticosterone; Hippocampus; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Septum Pellucidum; Spironolactone; Tissue Distribution | 1990 |
Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Androstanols; Animals; Bicarbonates; Carbenoxolone; Child; Electrolytes; Female; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Male; Mifepristone; Mineralocorticoids; Natriuresis; Pseudohypoaldosteronism; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1990 |
Role of aldosterone in the sodium retention of patients with nephrotic syndrome.
Topics: Adult; Aldosterone; Blood Pressure; Glomerular Filtration Rate; Humans; Male; Middle Aged; Nephrotic Syndrome; Potassium; Renin; Sodium; Sodium, Dietary; Spironolactone | 1990 |
Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism.
Topics: Adenoma; Administration, Oral; Adrenal Gland Neoplasms; Adult; Aldosterone; Corticosterone; Desoxycorticosterone; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoids; Monitoring, Physiologic; Potassium; Renin; Sodium; Spironolactone; Time Factors | 1990 |
Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure.
Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Pressure; Brain; Corticosterone; Glucocorticoids; Injections, Intraventricular; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Spironolactone | 1990 |
Intracerebroventricular infusion of RU28318 blocks aldosterone-salt hypertension.
Topics: Aldosterone; Animals; Blood Pressure; Cerebral Ventricles; Hypertension; Infusions, Parenteral; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Reference Values; Sodium, Dietary; Spironolactone | 1990 |
Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats.
Topics: Aldosterone; Animals; Blood Pressure; Hypertension; Male; Nephrectomy; Rats; Rats, Inbred Strains; Reference Values; Spironolactone; Urine | 1990 |
Differentiation of frog skin active Na+ transport during metamorphosis is induced by thyroid hormone.
Topics: Aldosterone; Animals; Biological Transport, Active; Corticosterone; Electrodes; Hydrocortisone; Metamorphosis, Biological; Metyrapone; Nystatin; Rana catesbeiana; Skin; Sodium; Spironolactone; Triiodothyronine | 1990 |
Aldosterone and spironolactone revisited.
Topics: Aldosterone; Humans; Spironolactone | 1990 |
Short- and long-term mechanisms of sudden cardiac death in congestive heart failure.
Topics: Aldosterone; Arrhythmias, Cardiac; Death, Sudden; Diuretics; Heart Failure; Humans; Magnesium; Potassium; Spironolactone | 1990 |
Binding of natural spirolactone derivatives to mineralo- and glucocorticoid receptors of the rat kidney.
Topics: Aldosterone; Animals; Binding, Competitive; Cytoplasm; Dexamethasone; Kidney; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1987 |
Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon.
Topics: Aldosterone; Animals; Circadian Rhythm; Colon; Electrophysiology; In Vitro Techniques; Intestinal Mucosa; Ion Channels; Microvilli; Rabbits; Sodium; Spironolactone | 1988 |
Further chemical differentiation of type I and type II adrenocorticosteroid receptors in mouse brain cytosol: evidence for a new class of glucocorticoid receptors.
Topics: Aldosterone; Androstanols; Animals; Brain Chemistry; Cytosol; Dextrans; Dithionitrobenzoic Acid; Female; Mice; Potassium Chloride; Receptors, Glucocorticoid; Spironolactone; Subcellular Fractions | 1988 |
Response of exocrine pancreas to corticosterone and aldosterone after adrenalectomy.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Amylases; Animals; Body Weight; Corticosterone; Female; Pancreas; Rats; Rats, Inbred Strains; Spironolactone | 1989 |
The cellular pool of Na+ channels in the amphibian cell line A6 is not altered by mineralocorticoids. Analysis using a new photoactive amiloride analog in combination with anti-amiloride antibodies.
Topics: Affinity Labels; Aldosterone; Amiloride; Animals; Blotting, Western; Cattle; Cell Line; Kidney; Microsomes; Mineralocorticoids; Photochemistry; Sodium Channels; Spectrophotometry, Ultraviolet; Spironolactone; Xenopus laevis | 1989 |
Aldosterone-stimulated down-regulation of both type I and type II adrenocorticosteroid receptors in mouse brain is mediated via type I receptors.
Topics: Aldosterone; Androstanols; Animals; Brain; Corticosterone; Dexamethasone; Female; Mice; Mice, Inbred Strains; Receptors, Corticotropin; Receptors, Pituitary Hormone; Spironolactone; Time Factors | 1989 |
Mineralocorticoid-induced increase in beta-adrenergic receptors of cultured rat arterial smooth muscle cells.
Topics: Aldosterone; Animals; Cells, Cultured; Cyclic AMP; Cycloheximide; Dihydroalprenolol; Mifepristone; Muscle, Smooth, Vascular; Rats; Receptors, Adrenergic, beta; Spironolactone | 1989 |
Differential effects of corticosteroids on Na+ transport in rat distal colon in vitro.
Topics: Aldosterone; Amiloride; Animals; Biological Transport, Active; Colon; Dexamethasone; Electrophysiology; Ion Channels; Male; Rats; Rats, Inbred Strains; Sodium; Spironolactone; Stimulation, Chemical | 1985 |
Comparative dose-effect studies with four C-17-spirosteroidal mineralocorticoid synthesis inhibitors.
Topics: Aldosterone; Analysis of Variance; Animals; Canrenone; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Oxazoles; Pregnadienes; Rats; Rats, Inbred Strains; Spiro Compounds; Spironolactone; Zona Glomerulosa | 1989 |
Plasma aldosterone level in a female case of pseudohyperaldosteronism (Liddle's syndrome).
Topics: Adult; Aldosterone; Blood Pressure; Dexamethasone; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Menstrual Cycle; Potassium; Renin; Sodium; Spironolactone; Triamterene | 1989 |
Direct vascular effects of 19-hydroxyandrostenedione.
Topics: Aldosterone; Androstenedione; Animals; Desipramine; Dose-Response Relationship, Drug; Ear; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rabbits; Regional Blood Flow; Spironolactone; Vasoconstriction | 1989 |
High affinity binding and regulatory actions of dexamethasone-type I receptor complexes in mouse brain.
Topics: Aldosterone; Animals; Brain; Cytosol; Dexamethasone; DNA-Binding Proteins; Estrenes; Female; Glucocorticoids; Kinetics; Mice; Mifepristone; Organ Specificity; Receptors, Glucocorticoid; Spironolactone | 1989 |
Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport.
Topics: Aldosterone; Amiloride; Androstanols; Animals; Biological Transport, Active; Colon; Dexamethasone; Male; Membrane Potentials; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone; Tetraethylammonium; Tetraethylammonium Compounds | 1989 |
New findings in apparent mineralocorticoid excess.
Topics: Adrenocorticotropic Hormone; Aldosterone; Child; Child, Preschool; Cortisone; Female; Humans; Hydrocortisone; Hypertension; Hypoaldosteronism; Hypokalemia; Male; Mineralocorticoids; Renin; Sodium; Sodium, Dietary; Spironolactone; Syndrome | 1987 |
Paradoxical differences in the receptor binding of two new antimineralocorticoids.
Topics: Adrenalectomy; Aldosterone; Animals; Cytosol; Hot Temperature; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Thermodynamics | 1988 |
Mineralocorticoid regulation of transcription of transfected mouse mammary tumor virus DNA in cultured kidney cells.
Topics: Aldosterone; Animals; Cats; Cell Line; DNA, Viral; Gene Expression Regulation; Kidney; Mammary Tumor Virus, Mouse; Receptors, Mineralocorticoid; Receptors, Steroid; Regulatory Sequences, Nucleic Acid; Spironolactone; Structure-Activity Relationship; Transcription, Genetic | 1988 |
Central interactions between aldosterone and vasopressin on cardiovascular system.
Topics: Aldosterone; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Carbachol; Cardiovascular System; Drug Interactions; Heart Rate; Male; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Vasopressins | 1988 |
Extrarenal effects of aldosterone and antimineralocorticoid compounds.
Topics: Aldosterone; Animals; Biological Transport, Active; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred Strains; Sodium Channels; Spironolactone; Vasopressins | 1988 |
Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids.
Topics: Aldosterone; Angiotensin II; Animals; Astrocytes; Brain Stem; Cells, Cultured; Corticosterone; Cycloheximide; Desoxycorticosterone; Dexamethasone; Dose-Response Relationship, Drug; Estradiol; Hypothalamus; Mineralocorticoids; Neurons; Progesterone; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Spironolactone; Testosterone | 1989 |
Role of atrial natriuretic peptide in mineralocorticoid escape phenomenon in patients with primary aldosteronism.
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Middle Aged; Mineralocorticoids; Natriuresis; Potassium; Renin; Spironolactone | 1987 |
Plasma atrial natriuretic peptide (ANP) in primary aldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aldosterone; Atrial Natriuretic Factor; Female; Furosemide; Humans; Hyperaldosteronism; Hyperplasia; Isotonic Solutions; Male; Middle Aged; Radioimmunoassay; Sodium Chloride; Spironolactone | 1988 |
Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnenes; Ranidae; Spironolactone; Structure-Activity Relationship; Veratrum Alkaloids | 1985 |
Glucocorticoid-suppressible hyperaldosteronism. Ultrastructural observation of a case.
Topics: Adrenal Cortex; Aldosterone; Dexamethasone; Endoplasmic Reticulum; Female; Humans; Hyperaldosteronism; Hypertrophy; Middle Aged; Receptors, Cell Surface; Receptors, Corticotropin; Renin-Angiotensin System; Spironolactone | 1985 |
Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists.
Topics: Aldosterone; Animals; Binding, Competitive; Chromatography, Ion Exchange; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1986 |
Regulation of renal Na+-K+-ATPase in the rat: role of increased potassium transport.
Topics: Adrenalectomy; Aldosterone; Animals; Biological Transport; Diet; Kidney Tubules; Kidney Tubules, Collecting; Male; Potassium; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1986 |
Spironolactone-reversible rickets associated with 11 beta-hydroxysteroid dehydrogenase deficiency syndrome.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Aldosterone; Alkalosis; Bone and Bones; Child; Female; Humans; Hydroxysteroid Dehydrogenases; Hypertension; Hypokalemia; Minerals; Parathyroid Glands; Posture; Renin; Rickets; Sodium; Spironolactone; Steroids; Syndrome; Triamterene | 1986 |
Studies on mechanisms of antinephritic action of SA-446 an angiotensin I converting enzyme inhibitor (1). A comparison with actions of spironolactone, kallidinogenase and saralasin.
Topics: 3-Mercaptopropionic Acid; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Urea Nitrogen; Kallikreins; Kidney Glomerulus; Male; Nephritis; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Renin; Saralasin; Spironolactone; Sulfhydryl Compounds; Thiazolidines | 1986 |
Activation of mineralocorticoid agonist and antagonist specific receptors from rat kidney.
Topics: Aldosterone; Animals; Cytosol; Kidney; Kinetics; Male; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1987 |
Activation of luminal Na+/H+ exchange in distal nephron of frog kidney. An early response to aldosterone.
Topics: Aldosterone; Amiloride; Animals; Carrier Proteins; Electrochemistry; Hydrogen-Ion Concentration; Kidney; Nephrons; Rana pipiens; Sodium-Hydrogen Exchangers; Spironolactone | 1987 |
Successful treatment of hyperkalemic quadriplegia associated with spironolactone.
Topics: Acid-Base Equilibrium; Aged; Aldosterone; Blood Glucose; Electrocardiography; Electrolytes; Female; Humans; Hyperkalemia; Insulin; Quadriplegia; Renin; Renin-Angiotensin System; Spironolactone | 1988 |
Effect of spironolactone on the renin-aldosterone system in rats.
Topics: Aldosterone; Animals; Male; Potassium; Rats; Rats, Inbred Strains; Renin; Renin-Angiotensin System; Sodium; Spironolactone | 1988 |
Effect of aldosterone antagonists on aldosterone-induced activation of Mg2+ -HCO3- -ATPase and carbonic anhydrase in rat intestinal mucosa.
Topics: Adenosine Triphosphatases; Adrenalectomy; Aldosterone; Animals; Ca(2+) Mg(2+)-ATPase; Canrenoic Acid; Carbonic Anhydrases; Dactinomycin; Duodenum; Enzyme Activation; Intestinal Mucosa; Jejunum; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone | 1985 |
The role of aldosterone in potassium tolerance: studies in anephric humans.
Topics: Adult; Aldosterone; Desoxycorticosterone; Female; Humans; Kidney; Male; Middle Aged; Nephrectomy; Potassium; Potassium Chloride; Renal Dialysis; Spironolactone | 1988 |
Mineralocorticoid activity and the excretion of an oral potassium load in normal man.
Topics: Adult; Aldosterone; Fludrocortisone; Humans; Kidney; Male; Natriuresis; Potassium; Sodium, Dietary; Spironolactone | 1988 |
Effect of spironolactone on glucocorticoid-induced colonic cation transport.
Topics: Adrenalectomy; Aldosterone; Animals; Biological Transport; Cations; Colon; Dexamethasone; Male; Potassium; Rats; Rats, Inbred Strains; Reference Values; Spironolactone | 1988 |
Solubilization of rat kidney plasma membrane proteins associated with 3H-aldosterone.
Topics: Adrenalectomy; Aldosterone; Animals; Binding, Competitive; Chromatography, Gel; Kidney; Kinetics; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Sodium Dodecyl Sulfate; Solubility; Spironolactone; Tritium | 1988 |
Corticosteroid regulation of Na+ and K+ transport in the rat distal colon during postnatal development.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aging; Aldosterone; Amiloride; Animals; Animals, Suckling; Colon; Corticosterone; Dexamethasone; Estrenes; Mifepristone; Potassium; Rats; Sodium; Spironolactone | 1988 |
Aldosterone is a physiologically significant kaliuretic hormone.
Topics: Adrenalectomy; Aldosterone; Animals; Electrolytes; Female; Homeostasis; Potassium; Rats; Rats, Inbred Strains; Renin; Sodium; Spironolactone | 1987 |
Efficacy and safety of lasilactone, a new combination diuretic, in essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Drug Combinations; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Potassium; Pulse; Renin; Spironolactone | 1987 |
[Urinary excretion of kallikrein and prostaglandins before and after sodium deprivation and their relationships to plasma vasopressive substances].
Topics: Adult; Aldosterone; Diet, Sodium-Restricted; Humans; Kallikreins; Male; Norepinephrine; Prostaglandins; Renin; Spironolactone | 1987 |
Glucocorticoids have a different action than aldosterone on target tissue.
Topics: Adrenalectomy; Aldosterone; Amiloride; Androstanols; Animals; Colon; Electrophysiology; Glucocorticoids; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1988 |
The reoxidation of cytochrome P-450 by paraquat inhibits aldosterone biosynthesis from 18-hydroxycorticosterone.
Topics: 18-Hydroxycorticosterone; Adrenal Glands; Aldosterone; Animals; Corticosterone; Cytochrome P-450 Enzyme System; Ducks; Kinetics; Male; Metyrapone; Mineralocorticoid Receptor Antagonists; Mitochondria; Oxidation-Reduction; Paraquat; Reference Values; Spironolactone | 1988 |
Apparent mineralocorticoid excess causing hypertension and hypokalemia in children.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Child; Child, Preschool; Female; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hypertension; Hypokalemia; Male; Metyrapone; Mineralocorticoids; Spironolactone; Syndrome | 1986 |
Adaptation to chronic potassium loading in normal man.
Topics: Acetazolamide; Adaptation, Biological; Administration, Oral; Adult; Aldosterone; Body Weight; Canrenoic Acid; Humans; Infusions, Parenteral; Injections, Intravenous; Kidney Tubules; Male; Potassium; Renin; Spironolactone; Time Factors | 1986 |
Salt appetite is suppressed by interference with angiotensin II and aldosterone.
Topics: Aldosterone; Angiotensin II; Animals; Appetite; Captopril; Cerebral Ventricles; Insulin; Male; Natriuresis; Rats; Rats, Inbred Strains; Sodium Chloride; Spironolactone | 1986 |
Liddle's syndrome, an uncommon form of hyporeninemic hypoaldosteronism: functional and histopathological studies.
Topics: Aged; Aldosterone; Humans; Kidney; Male; Renin; Spironolactone; Syndrome; Triamterene | 1987 |
Effects of adrenal steroids on Na transport in the lower intestine (coprodeum) of the hen.
Topics: Aldosterone; Animals; Biological Transport; Chickens; Dexamethasone; Diet, Sodium-Restricted; Female; Intestinal Mucosa; Intestines; Membrane Potentials; Sodium; Spironolactone | 1987 |
Amiloride-sensitive sodium transport of the rat distal colon during early postnatal development.
Topics: Adrenalectomy; Aldosterone; Amiloride; Animals; Biological Transport; Colon; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Sodium; Spironolactone; Weaning | 1987 |
Aldosterone-induced, amiloride-inhibitable short-circuit current in the avian ileum.
Topics: Aldosterone; Amiloride; Animals; Chickens; Corticosterone; Diet, Sodium-Restricted; Electrophysiology; Ileum; Intestinal Mucosa; Mineralocorticoid Receptor Antagonists; Serous Membrane; Sodium; Spironolactone | 1987 |
Binding and action of glucocorticoids and mineralocorticoids in rabbit mammary gland. Exclusive participation of glucocorticoid type II receptors for stimulation of casein synthesis.
Topics: Aldosterone; Androstanols; Animals; Caseins; Culture Techniques; Female; Glucocorticoids; Mammary Glands, Animal; Mineralocorticoids; Rabbits; Receptors, Glucocorticoid; Spironolactone | 1987 |
Aldosterone effects on salt appetite in adrenalectomized rats.
Topics: Adrenalectomy; Aldosterone; Animals; Appetite; Brain Chemistry; Corticosterone; Drinking Behavior; Drug Interactions; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Sodium Chloride; Spironolactone | 1986 |
Adrenocorticoid-dependent alpha-lactalbumin synthesis in rat mammary gland explants: antagonist studies.
Topics: Aldosterone; Androstanols; Animals; Culture Techniques; Dexamethasone; Female; Glucocorticoids; Lactalbumin; Mammary Glands, Animal; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Spironolactone | 1986 |
Effect of aldosterone on dome formation by MDCK mono-layer.
Topics: Aldosterone; Animals; Biological Transport; Cell Line; Dogs; Epithelium; Kidney; Spironolactone | 1986 |
Corticosteroids decrease glomerular angiotensin receptors.
Topics: Adrenal Cortex Hormones; Aldosterone; Angiotensin II; Animals; Hemodynamics; Kidney Glomerulus; Male; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Sodium; Spironolactone | 1987 |
Captopril before and after spironolactone therapy in primary aldosteronism. Pathogenetic and therapeutical aspects.
Topics: Aldosterone; Blood Pressure; Captopril; Drug Therapy, Combination; Humans; Hypertension; Potassium; Proline; Renin; Spironolactone | 1985 |
Essential hypertension: a metabolic cause? A hypothesis.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Calcium; Captopril; Female; Humans; Hydrochlorothiazide; Hypertension; Lactates; Lactic Acid; Male; Middle Aged; Potassium; Potassium Chloride; Propranolol; Renin; Spironolactone | 1985 |
Intracerebroventricular infusion of aldosterone induces hypertension in rats.
Topics: Aldosterone; Animals; Brain; Cerebral Ventricles; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone | 1986 |
Importance of plasma aldosterone concentration on the natriuretic effect of spironolactone in patients with liver cirrhosis and ascites.
Topics: Aldosterone; Diuretics; Dose-Response Relationship, Drug; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Natriuresis; Spironolactone | 1985 |
Effect of spironolactone on the renal clearance of digoxin in dogs.
Topics: Aldosterone; Animals; Digoxin; Dogs; Inulin; Kidney; Metabolic Clearance Rate; Potassium; Quinidine; Sodium; Spironolactone | 1985 |
Aldosterone metabolism and transepithelial potential difference in normal and cystic fibrosis subjects.
Topics: Adult; Aldosterone; Canrenone; Cystic Fibrosis; Electrophysiology; Epithelium; Female; Humans; Male; Nose; Rectum; Reference Values; Spironolactone | 1985 |
Progestogens with antimineralocorticoid activity.
Topics: Adrenalectomy; Aldosterone; Androstadienes; Androstenes; Animals; Canrenoic Acid; Canrenone; Cyproterone; Dose-Response Relationship, Drug; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Norethindrone; Norgestrel; Norpregnenes; Potassium; Progesterone; Progesterone Congeners; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1985 |
Rat C6 glioma cells contain type I as well as type II corticosteroid receptors.
Topics: Adrenal Cortex Hormones; Aldosterone; Androstanols; Animals; Cell Line; Corticosterone; Desoxycorticosterone; Dexamethasone; Glioma; Progesterone; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Spironolactone; Triamcinolone | 1985 |
Hypertension with aldosterone excess and low plasma-renin: preoperative distinction between patients with and without adrenocortical tumour.
Topics: Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Age Factors; Aged; Aldosterone; Blood Pressure; Carbon Dioxide; Computers; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Renin; Retrospective Studies; Sex Factors; Sodium; Spironolactone; Statistics as Topic | 1970 |
Idiopathic oedema.
Topics: Adrenal Glands; Aldosterone; Diuretics; Edema; Female; Gonadal Steroid Hormones; Humans; Plasma Volume; Serum Albumin; Spironolactone; Thiazines; Vascular Diseases | 1972 |
Apparently isolated excess deoxycorticosterone in hypertension. A variant of the mineralocorticoid-excess syndrome.
Topics: 17-Ketosteroids; Adult; Aged; Aldosterone; Chromatography, Gas; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydroxycorticosteroids; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Radioimmunoassay; Renin; Spironolactone; Syndrome | 1972 |
[Pilot study on the efficacy of high doses of aldosterone and spirolactone derivatives in the treatment of multiple sclerosis].
Topics: Adult; Aldosterone; Blood Pressure Determination; Body Weight; Chronic Disease; Electrocardiography; Electroencephalography; Electrolytes; Female; Humans; Injections, Intravenous; Lectins; Lymphocyte Activation; Male; Middle Aged; Multiple Sclerosis; Pilot Projects; Spironolactone; Vomiting | 1972 |
Disturbances of electrical activity of the brain induced by the spirolactone derivative potassium canrenoate.
Topics: Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Animals; Brain; Brain Edema; Cortical Synchronization; Dogs; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Spironolactone | 1973 |
The role of adrenal corticosteroids in the regulation of kidney function in the desert lizard Dipsosaurus dorsalis.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Corticosterone; Dexamethasone; Ethanol; Glomerular Filtration Rate; Inulin; Kidney; Lizards; Natriuresis; Photometry; Sodium; Sodium Chloride; Spironolactone; Time Factors; Tritium | 1972 |
Clinical investigation of the effects of adrenal corticosteroid excess on the colon.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adult; Aldosterone; Colon; Corticosterone; Desoxycorticosterone; Dialysis; Feces; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Magnesium; Magnesium Sulfate; Male; Middle Aged; Potassium; Sodium; Spironolactone; Urea | 1969 |
Colonic effects of adrenal corticosteroid excess.
Topics: Aldosterone; Animals; Colon; Dogs; Humans; Intestinal Absorption; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone | 1969 |
Aldosterone-induced protein in toad urinary bladder.
Topics: Aldosterone; Animals; Biological Transport, Active; Bufo marinus; Dactinomycin; In Vitro Techniques; Insulin; Kinetics; Membrane Potentials; Methionine; Mineralocorticoid Receptor Antagonists; Molecular Weight; Peptide Biosynthesis; Protein Biosynthesis; Sodium; Spironolactone; Stimulation, Chemical; Sulfur Radioisotopes; Urinary Bladder | 1974 |
Kinetics of RNA labeling in toad bladder epithelium: effects of aldosterone and related steroids.
Topics: Aldosterone; Animals; Anura; Biological Transport, Active; Bufo marinus; Carbon Radioisotopes; Epithelium; Female; Hydrocortisone; Kinetics; Methionine; Mineralocorticoid Receptor Antagonists; RNA; RNA, Messenger; Sodium; Spironolactone; Stimulation, Chemical; Tritium; Uridine; Urinary Bladder | 1974 |
The influence of a heparin-like compound on hypertension, electrolytes and aldosterone in man.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aldosterone; Blood Pressure; Female; Glycosaminoglycans; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Spironolactone; Urine; Water-Electrolyte Balance | 1966 |
[Further observations on the inhibition of aldosterone, on the acclimitation to heat, in white rats].
Topics: Adaptation, Physiological; Aldosterone; Animals; Female; Hot Temperature; Male; Rats; Spironolactone | 1966 |
[Experimental study on the prevention of steroid-induced gastric ulcer].
Topics: Aldosterone; Animals; Antacids; Cellulose; Desoxycorticosterone; Female; Gastric Juice; Gastrointestinal Hormones; Glycosaminoglycans; Mucins; Peptic Ulcer; Prednisolone; Rats; Spironolactone; Stomach | 1971 |
On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro.
Topics: Adrenal Glands; Aldosterone; Androstanes; Animals; Cardanolides; Corticosterone; Diet; Dose-Response Relationship, Drug; Ketosteroids; Male; Mass Spectrometry; Mineralocorticoid Receptor Antagonists; Rats; Sodium; Spironolactone | 1973 |
Extrarenal effects of aldosterone antagonists in guinea pigs. I. Enhanced transport of potassium into the cells.
Topics: Aldosterone; Animals; Extracellular Space; Female; Guinea Pigs; Heart; In Vitro Techniques; Magnesium; Male; Mineralocorticoid Receptor Antagonists; Muscles; Myocardium; Potassium; Sodium; Spironolactone | 1973 |
Proceedings: On the role of diuretic-and spironolactone-induced hyperaldosteronism on electrolyte excretion in man.
Topics: Aldosterone; Diuretics; Furosemide; Humans; Hyperaldosteronism; Potassium; Sodium; Spironolactone; Time Factors | 1974 |
Separate effects of aldosterone, DOCA, and methylprednisolone on renal Na-K-ATPase,.
Topics: Adenosine Triphosphatases; Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Diet, Sodium-Restricted; Kidney; Kidney Cortex; Kidney Medulla; Male; Methylprednisolone; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Sodium Chloride; Spironolactone | 1974 |
Inhibition of aldosterone production in diuretic-induced hyperaldosteronism by aldosterone antagonist canrenone in man.
Topics: Aldosterone; Butanes; Depression, Chemical; Diuresis; Hematocrit; Humans; Hydrochlorothiazide; Hyperaldosteronism; Ketosteroids; Lactones; Male; Mineralocorticoid Receptor Antagonists; Natriuresis; Potassium; Pregnadienes; Sodium; Spironolactone; Time Factors | 1974 |
The effect of saluretics and spironolactone on aldosterone production and electrolyte excretion in man.
Topics: Adult; Aldosterone; Butanes; Diuresis; Female; Furosemide; Humans; Hydrochlorothiazide; Hyperaldosteronism; Male; Natriuresis; Potassium; Sodium; Spironolactone | 1974 |
Adrenocortical nuclear volume and adrenocortical function.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Desoxycorticosterone; Heparin; Hydrocortisone; Injections, Intramuscular; Injections, Intraperitoneal; Pituitary-Adrenal Function Tests; Rats; Spironolactone | 1965 |
Normotensive secondary hyperaldosteronism.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Child, Preschool; Diet Therapy; Dwarfism; Female; Humans; Hyperaldosteronism; Hypokalemia; Juxtaglomerular Apparatus; Kidney Function Tests; Male; Norepinephrine; Potassium; Renin; Sodium; Spironolactone | 1966 |
Hypoglycemia in Meniere's disease.
Topics: Adrenocorticotropic Hormone; Aldosterone; Desoxycorticosterone; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Glucocorticoids; Glucose; Glucose Tolerance Test; Humans; Hydrocortisone; Hypoglycemia; Insulin; Meniere Disease; Potassium; Spironolactone | 1968 |
[The influence of aldosterone and aldosterone antagonists on the pressor effect of synthetic Angiotensin II in primary chronic adrenal cortex insufficiency (M. Addison)].
Topics: Addison Disease; Adult; Aldosterone; Angiotensin II; Blood Pressure; Glucocorticoids; Humans; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Progesterone; Spironolactone; Vasomotor System | 1966 |
[On the effect of heparin and corticoid therapy on the number of circulating eosinophils].
Topics: Adrenocorticotropic Hormone; Aldosterone; Cortisone; Depression, Chemical; Desoxycorticosterone; Eosinophils; Fractures, Bone; Heparin; Hernia; Humans; Injections, Intramuscular; Injections, Intravenous; Spironolactone; Stimulation, Chemical | 1966 |
Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter's syndrome).
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Ammonium Chloride; Angiotensin II; Bicarbonates; Body Height; Body Weight; Catecholamines; Child; Chlorides; Diet; Female; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hyperplasia; Juxtaglomerular Apparatus; Kidney Diseases; Kidney Function Tests; Metyrapone; Microscopy, Electron; Muscles; Norepinephrine; Pituitary-Adrenal Function Tests; Potassium; Renin; Serum Albumin; Sodium; Spironolactone; Triamterene; Water-Electrolyte Balance | 1968 |
Primary periodic paralysis associated with hyperkalemic and hypokalemic attacks and with hemolytic bilirubinemia.
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Adult; Aldosterone; Bilirubin; Dexamethasone; Diet, Sodium-Restricted; Electrocardiography; Electromyography; Furosemide; Humans; Hyperbilirubinemia; Hyperkalemia; Hypokalemia; Leg; Male; Metyrapone; Paralyses, Familial Periodic; Pelvis; Potassium; Sodium; Spironolactone | 1968 |
[Karyometric studies of the clarification of the osmo-or volume regulatgry role of the subcommissural organ and its functional connection with the adrenal cortex].
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Animals; Dehydration; Desoxycorticosterone; Diencephalon; Hydrocortisone; Injections, Intraperitoneal; Karyometry; Male; Rats; Spironolactone; Thalamus; Water-Electrolyte Balance | 1968 |
Activation of aldosterone secretion in primary aldosteronism.
Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Glucocorticoids; Humans; Hyperaldosteronism; Pituitary-Adrenal Function Tests; Renin; Spironolactone | 1969 |
[Differential diagnosis of the Bartter syndrome].
Topics: Adult; Aldosterone; Alkalosis; Angiotensin II; Biopsy; Chymosin; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hypokalemia; Kidney; Sodium; Spironolactone | 1968 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Angiotensin II; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Spironolactone | 1969 |
Effect of aldosterone on angiotensin-induced glycosuria.
Topics: Aldosterone; Angiotensin II; Animals; Glycosuria; Hyperglycemia; Injections, Intravenous; Rabbits; Renin; Spironolactone; Time Factors; Urine | 1969 |
Mechanism of angiotensin-induce glycosuria.
Topics: Aldosterone; Angiotensin II; Animals; Blood Glucose; Epinephrine; Glycosuria; Hyperglycemia; Injections, Intravenous; Mouth; Rabbits; Spironolactone; Time Factors; Urine | 1969 |
Pathogenesis of Bartter's syndrome.
Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Albumins; Aldosterone; Alkalosis; Angiotensin II; Aniline Compounds; Anticonvulsants; Child; Dexamethasone; Female; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Juxtaglomerular Apparatus; Kidney; Norepinephrine; Potassium; Potassium Chloride; Pyridones; Renin; Secretory Rate; Sodium; Spironolactone | 1969 |
Suppressed plasma renin activity in essential hypertension. Roles of plasma volume, blood pressure, and sympathetic nervous system.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Blood Volume; Catecholamines; Diet; Epinephrine; Extracellular Space; Female; Guanethidine; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Posture; Potassium; Renin; Sodium; Spironolactone; Sympathetic Nervous System | 1970 |
[Chronic idiopathic hypokalemia with hyperkaliuria in a very young infant. (Bioclinical and histological study)].
Topics: Aldosterone; Alkalosis; Angiotensin II; Calcium; Chlorides; Diet, Sodium-Restricted; Growth Disorders; Humans; Hypokalemia; Infant; Kidney; Kidney Function Tests; Lipids; Male; Potassium; Potassium Chloride; Sodium; Spironolactone | 1969 |
Interrelationships of renin and aldosterone in a patient with hypoaldosteronism.
Topics: Adrenal Insufficiency; Aged; Aldosterone; Angiotensin II; Diet; Diet, Sodium-Restricted; Female; Humans; Renin; Sodium Chloride; Spironolactone | 1970 |
An unusual type of hypokalaemic alkalosis with a disturbance of renin and aldosterone.
Topics: Adolescent; Adrenal Cortex Hormones; Albumins; Aldosterone; Alkalosis; Angiotensin II; Creatinine; Diet, Sodium-Restricted; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Kidney Diseases; Male; Potassium; Renin; Spironolactone; Triamterene | 1970 |
Case studies of siblings with juxtaglomerular hyperplasia and secondary aldosteronism associated with severe azotemia and renal rickets--Bartter's syndrome or disease?
Topics: Aldosterone; Alkalosis; Angiotensin II; Bone Diseases; Child; Child, Preschool; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Juxtaglomerular Apparatus; Kidney Diseases; Kidney Glomerulus; Male; Spironolactone; Triamterene; Valine | 1970 |
Neurodegenerative disorders and hyperaldosteronism.
Topics: Adolescent; Aldosterone; Angiotensin II; Birth Weight; Blood Pressure; Body Weight; Bundle-Branch Block; Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Child; Electrocardiography; Electroencephalography; Electromyography; Eye Diseases; Female; Humans; Hyperaldosteronism; Intelligence; Leukoencephalitis, Acute Hemorrhagic; Magnesium; Male; Nerve Degeneration; Potassium; Retinal Diseases; Retinal Pigments; Sodium; Spironolactone | 1971 |
[The renin-angiotensin-aldosterone system. Disorders and methods of clinical research].
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Aldosterone; Angiotensin II; Dexamethasone; Electrolytes; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Methods; Mineralocorticoids; Pituitary-Adrenal Function Tests; Radioimmunoassay; Renin; Spironolactone | 1970 |
[Urinary excretion of aldosterone in experimental saturnism].
Topics: Aldosterone; Angiotensin II; Animals; Lead Poisoning; Rabbits; Renin; Spironolactone | 1971 |
Drug modification of digital vascular reactivity to vasoactive substances.
Topics: Aldosterone; Angiotensin II; Benzothiadiazines; Blood Pressure; Dihydroxyphenylalanine; Fingers; Guanethidine; Humans; Hypertension; Hypertension, Renal; Norepinephrine; Prednisone; Raynaud Disease; Regional Blood Flow; Sodium Chloride; Spironolactone; Tyramine; Vasoconstrictor Agents; Vasodilator Agents | 1969 |
Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess, and low plasma renin.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Blood Volume; Body Weight; Extracellular Space; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Postoperative Care; Potassium; Renin; Sodium; Spironolactone; Urea | 1972 |
Low renin hypertension and the adrenal cortex.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Blood Pressure; Corticosterone; Desoxycorticosterone; Diuresis; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypertension; Hypokalemia; Indoles; Male; Pyridines; Renin; Secretory Rate; Spironolactone; Sulfonic Acids | 1972 |
Stimulation of aldosterone production in vitro and its inhibition by spironolactone.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Butyrates; Chromatography, Gas; Chromatography, Thin Layer; Cyclic AMP; Esters; In Vitro Techniques; Lactones; Male; Mineralocorticoid Receptor Antagonists; Oxidation-Reduction; Potassium; Rats; Rats, Inbred Strains; Spironolactone | 1972 |
A kindred with familial glucocorticoid suppressible aldosteronism.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Binding, Competitive; Child; Dexamethasone; Female; Fluorometry; Humans; Hydralazine; Hydrocortisone; Hyperaldosteronism; Male; Methyldopa; Pregnanetriol; Radioimmunoassay; Renin; Spironolactone; Tetrahydrocortisone | 1973 |
Subacute necrotizing encephalomyelopathy with vacuolated cells in the bone marrow.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Amino Acids; Arginine; Bone Marrow; Bone Marrow Cells; Child, Preschool; Corticosterone; Demyelinating Diseases; Encephalomyelitis; Female; Growth Hormone; Humans; Hydrocortisone; Magnesium; Metyrapone; Spinal Cord; Spironolactone; Vitamin B Complex | 1972 |
Effect of mineralocorticoid agonists and antagonists on binding of 3 H-aldosterone to adrenalectomized rat kidney plasma membranes.
Topics: Adrenalectomy; Aldosterone; Animals; Binding, Competitive; Cell Membrane; Desoxycorticosterone; Estradiol; Fludrocortisone; In Vitro Techniques; Kidney; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Progesterone; Protein Binding; Rats; Receptors, Cell Surface; Spironolactone; Subcellular Fractions; Testosterone; Tritium | 1972 |
[Plasma aldosterone levels in primary aldosteronism. 1. Renin-angiotensin system and aldosterone].
Topics: Aldosterone; Angiotensin II; Enzyme Activation; Furosemide; Humans; Hydrochlorothiazide; Hyperaldosteronism; Posture; Renin; Spironolactone | 1973 |
Six year follow-up of a child with Bartter syndrome.
Topics: Aldosterone; Alkalosis; Angiotensin II; Biopsy; Blood Pressure; Child, Preschool; Diet Therapy; Female; Follow-Up Studies; Growth Disorders; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Juxtaglomerular Apparatus; Kidney Concentrating Ability; Kidney Diseases; Norepinephrine; Potassium; Renin; Secretory Rate; Sodium Chloride; Spironolactone; Syndrome; Vasopressins | 1973 |
Some observations on the pathogenesis of Bartter's syndrome.
Topics: Adult; Aldosterone; Alkalosis; Angiotensin II; Blood Volume; Drug Therapy, Combination; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Juxtaglomerular Apparatus; Kidney; Kidney Diseases; Male; Potassium; Propranolol; Renin; Spironolactone | 1973 |
Editorial: New knowledge of benign essential hypertension.
Topics: Age Factors; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Pressure; Ethnicity; Humans; Hypertension; Propranolol; Renin; Spironolactone | 1973 |
Control of plasma aldosterone in primary aldosteronism: distinction between adenoma and hyperplasia.
Topics: Adenoma; Adrenocorticotropic Hormone; Aldosterone; Circadian Rhythm; Dexamethasone; Diet; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hyperplasia; Male; Posture; Renin; Sodium; Spironolactone | 1973 |
Renal aldosterone receptors: studies with (3H)aldosterone and the anti-mineralocorticoid (3H)spirolactone (SC-26304).
Topics: Adrenalectomy; Aldosterone; Animals; Binding Sites; Binding, Competitive; Cell Fractionation; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; In Vitro Techniques; Kidney; Kidney Function Tests; Lactones; Mineralocorticoid Receptor Antagonists; Protein Binding; Rats; Receptors, Cell Surface; Spiro Compounds; Spironolactone; Tritium | 1974 |
Regulation of aldosterone in the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Hormones, Ectopic; Humans; Hydrocortisone; Male; Middle Aged; Natriuresis; Potassium; Radioimmunoassay; Renin; Sodium; Spironolactone; Syndrome; Vasopressins; Water Deprivation | 1974 |
Molecular modifications of anti-aldosterone compounds: effects on affinity of spirolactones for renal aldosterone receptors.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Binding, Competitive; Cytoplasm; Dexamethasone; Kidney; Lactones; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Potassium; Rats; Receptors, Cell Surface; Spironolactone; Structure-Activity Relationship; Tritium | 1974 |
An in vitro study of mineralocorticoid binding proteins from rat kidney.
Topics: Aldosterone; Animals; Binding Sites; Binding, Competitive; Cell Nucleus; Chromatin; Chromatography, Gel; Cytosol; Desoxycorticosterone; Estradiol; Fludrocortisone; In Vitro Techniques; Kidney; Male; Nucleoproteins; Protein Binding; Proteins; Rats; Receptors, Cell Surface; Solubility; Spironolactone; Tritium; Ultracentrifugation | 1974 |
Renin-angiotensin-aldosterone system of a woman with Bartter's syndrome: Juxtaglomerular cell hyperplasia without hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Female; Humans; Hyperaldosteronism; Hypokalemia; Juxtaglomerular Apparatus; Kidney Diseases; Potassium; Potassium Chloride; Radioisotope Renography; Renin; Sodium; Sodium Chloride; Spironolactone; Syndrome | 1974 |
Reduced aldosterone secretion during spironolactone treatment in primary aldosteronism: report of a case.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Blood Pressure; Cholesterol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Iodine Radioisotopes; Middle Aged; Potassium; Renin; Spironolactone; Tritium | 1974 |
The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.
Topics: Adult; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hypokalemia; Male; Metyrapone; Mineralocorticoids; Paralysis; Periodicity; Sodium; Spironolactone | 1974 |
Pseudohypoaldosteronism: persistence of hyperaldosteronism and evidence for renal tubular and intestinal responsiveness to endogenous aldosterone.
Topics: Aldosterone; Angiotensin II; Child; Colon; Creatinine; Feces; Humans; Hydrocortisone; Hyperaldosteronism; Intestinal Mucosa; Kidney Function Tests; Kidney Tubules; Male; Potassium; Radioimmunoassay; Renin; Sodium; Spironolactone; Tritium | 1974 |
Aldosterone-induced increase in protein phosphatase activity of toad bladder.
Topics: Adenosine Triphosphate; Aldosterone; Animals; Autoradiography; Bufo marinus; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Activation; In Vitro Techniques; Microsomes; Mineralocorticoid Receptor Antagonists; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Proteins; Puromycin; Spironolactone; Urinary Bladder | 1974 |
Redox state of pyridine nucleotides in renal response to aldosterone.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Citrates; Cytoplasm; Female; Hydrocortisone; Kidney; Lyases; Mitochondria; NAD; NADP; Oxidation-Reduction; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1972 |
Adaptation to the natriuretic actions of hydrochlorothiazide, frusemide and amiloride, by rats.
Topics: Adaptation, Physiological; Adrenal Glands; Adrenalectomy; Aldosterone; Amiloride; Animals; Corticosterone; Diuresis; Diuretics; Female; Furosemide; Hydrochlorothiazide; Juxtaglomerular Apparatus; Natriuresis; Potassium; Pyrazines; Rats; Renin; Sodium; Sodium Chloride; Spironolactone; Time Factors | 1972 |
Idiopathic edema.
Topics: Adult; Age Factors; Aldosterone; Edema; Female; Heart Failure; Humans; Hydrochlorothiazide; Hydrostatic Pressure; Hyperaldosteronism; Liver Cirrhosis; Male; Nephrosis; Osmotic Pressure; Posture; Renin; Sex Factors; Sodium; Spironolactone; Water-Electrolyte Balance | 1974 |
Urinary kallikrein excretion in normal man. Relationships to sodium intake and sodium-retaining steroids.
Topics: Adolescent; Adult; Aldosterone; Amylases; Biological Assay; Diet; Diet, Sodium-Restricted; Drinking; Female; Fludrocortisone; Humans; Kallikreins; Male; Middle Aged; Molecular Weight; Potassium; Renin; Sodium; Sodium Chloride; Spironolactone; Water | 1974 |
Urinary kallikrein excretion in hypertensive man. Relationships to sodium intake and sodium-retaining steroids.
Topics: Adult; Aldosterone; Blood Pressure; Diet; Diet, Sodium-Restricted; Fludrocortisone; Humans; Hyperaldosteronism; Hypertension; Kallikreins; Male; Middle Aged; Natriuresis; Renin; Sodium; Spironolactone; Time Factors | 1974 |
Plasma aldosterone in essential hypertension with low renin activity.
Topics: Aldosterone; Body Weight; Corticosterone; Cushing Syndrome; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Kidney Failure, Chronic; Metabolism, Inborn Errors; Mixed Function Oxygenases; Posture; Potassium; Radioimmunoassay; Renin; Spironolactone | 1974 |
[Variations in renin and aldosterone activity in a typical case of Barter syndrome. Influence of anti-aldosterones and sodium intake].
Topics: Adult; Aldosterone; Bartter Syndrome; Biological Transport, Active; Biopsy; Humans; Hyperaldosteronism; Kidney; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Posture; Potassium; Renin; Sodium; Sodium Chloride; Spironolactone | 1974 |
Management of potassium problems during long-term diuretic therapy.
Topics: Aldosterone; Diet; Diuretics; Extracellular Space; Homeostasis; Humans; Hydrogen-Ion Concentration; Hyperaldosteronism; Hyperkalemia; Hypertension; Kidney; Loop of Henle; Methods; Plasma Volume; Potassium; Potassium Chloride; Spironolactone; Time Factors | 1974 |
Antihypertensive effect of spironolactone in essential, renal and mineralocorticoid hypertension.
Topics: Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney Diseases; Male; Mineralocorticoids; Mixed Function Oxygenases; Potassium; Renin; Spironolactone | 1973 |
[Mechanism of action of diuretics of the anti-aldosterone type].
Topics: Aldosterone; Amiloride; Diuresis; Diuretics; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Spironolactone; Triamterene | 1973 |
[Aldosterone, a possible substitute for glucocorticoids during immune therapy].
Topics: Aldosterone; Animals; Antilymphocyte Serum; Drug Synergism; Glucocorticoids; Immunosuppressive Agents; Male; Prednisolone; Rats; Rats, Inbred Strains; Skin Transplantation; Spironolactone; Transplantation Immunology; Transplantation, Autologous; Transplantation, Homologous | 1972 |
The aetiology of hypertension after renal transplantation in man.
Topics: Adrenalectomy; Aldosterone; Animals; Biological Assay; Carbon Radioisotopes; Cortisone; Humans; Hypertension, Renal; Kidney Transplantation; Methylprednisolone; Postoperative Complications; Posture; Prednisone; Radioimmunoassay; Rats; Renin; Secretory Rate; Spironolactone; Transplantation, Homologous | 1973 |
[Is essential hypertension still a disease entity? Definition of hyporeninemic hypertension].
Topics: Aldosterone; Amiloride; Chlorthalidone; Diagnosis, Differential; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Mineralocorticoids; Prognosis; Renin; Sodium Chloride; Spironolactone; Sympathetic Nervous System | 1974 |
Pitfalls in the surgery of aldosterone-producing tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Female; Humans; Male; Middle Aged; Spironolactone | 1972 |
Experience with the use of an aldosterone antagonist in selected hypertensive patients.
Topics: Adult; Aldosterone; Carbon Dioxide; Creatinine; Female; Humans; Hypertension; Kidney Function Tests; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone | 1972 |
[The effect of aldactone on aldosterone excretion and mineral metabolism in chronic cor pulmonale].
Topics: Aldosterone; Humans; Natriuresis; Pulmonary Heart Disease; Spironolactone | 1972 |
[Treatment of essential arterial hypertension with spironolactone: its value in the detection of primary hyperaldosteronism and prediction of its efficacy].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Age Factors; Aldosterone; Diet Therapy; Humans; Hyperaldosteronism; Hypertension; Potassium; Sodium; Spironolactone; Time Factors | 1972 |
Influence of aldosterone on sodium, water and potassium metabolism in chronic renal disease.
Topics: Aldosterone; Blood; Blood Urea Nitrogen; Body Water; Creatinine; Desoxycorticosterone; Diet, Sodium-Restricted; Extracellular Space; Feces; Glomerular Filtration Rate; Humans; Hydrocortisone; Kidney Concentrating Ability; Kidney Failure, Chronic; Mannitol; Osmolar Concentration; Plasma Volume; Potassium; Sodium; Spironolactone; Urea; Urine; Vasopressins | 1972 |
Studies on essential hypertension with suppressed plasma renin activity: sodium excretion pattern on salt restriction and effects of spironolactone on blood pressure and plasma renin activity.
Topics: Adult; Aldosterone; Blood Pressure; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone | 1972 |
The diagnostic and therapeutic value of spironolactone in patients with systemic hypertension.
Topics: Acid-Base Equilibrium; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Pressure; Body Weight; Creatinine; Female; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Male; Middle Aged; Potassium; Renal Artery Obstruction; Renin; Sodium; Spironolactone; Urea; Water-Electrolyte Balance | 1973 |
Renal potassium-wasting of unknown cause in a clinical setting of chronic potassium depletion: report of a case.
Topics: Aldosterone; Biopsy; Humans; Kidney; Kidney Tubules, Proximal; Magnesium; Male; Middle Aged; Muscular Diseases; Potassium; Potassium Deficiency; Renal Tubular Transport, Inborn Errors; Renin; Spironolactone | 1973 |
Complex formation by 3 H-aldosterone in rat kidney and liver.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Cell Nucleus; Cytosol; Glucuronidase; Kidney; Liver; Male; Natriuresis; Potassium; Protein Binding; Rats; Spectrophotometry, Ultraviolet; Spironolactone; Subcellular Fractions; Tritium | 1973 |
Volume-dependent essential and steroid hypertension.
Topics: Adult; Aged; Aldosterone; Diet, Sodium-Restricted; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypertension; Male; Middle Aged; Natriuresis; Plasma Volume; Renin; Sodium; Spironolactone; Water-Electrolyte Balance | 1973 |
[PHA-stimulation of blood lymphocytes in patients with multiple sclerosis during combined therapy with aldosterone and spirolactone derivatives].
Topics: Aldosterone; DNA; Humans; Lectins; Lymphocyte Activation; Multiple Sclerosis; Radioisotopes; Spironolactone; Thymine Nucleotides | 1973 |
Effect of aldosterone blockade during fasting and refeeding.
Topics: Adrenal Glands; Adult; Aldosterone; Dietary Carbohydrates; Fasting; Female; Humans; Kidney Tubules, Distal; Male; Natriuresis; Nutritional Physiological Phenomena; Obesity; Potassium; Secretory Rate; Sodium; Spironolactone; Time Factors; Water-Electrolyte Balance | 1973 |
Experience with primary aldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Renin; Spironolactone | 1973 |
Spironolactone as a nonspecific treatment for primary aldosteronism.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Creatinine; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hydrochlorothiazide; Hyperaldosteronism; Male; Middle Aged; Plasma Volume; Potassium; Renin; Sodium; Spironolactone | 1973 |
Volume factor in low and normal renin essential hypertension. Treatment with either spironolactone or chlorthalidone.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Chlorthalidone; Creatinine; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone | 1973 |
[Treatment of essential arterial hypertension with spironolactone: its value for the screening of primary hyperaldosteronism and prediction of its efficacy].
Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Probability; Spironolactone | 1973 |
[The role of anti-aldosterones in the treatment of arterial hypertension].
Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone | 1973 |
Effect of adrenal cortical steroids on liver regeneration.
Topics: Adrenalectomy; Aldosterone; Animals; Cortisone; Dexamethasone; Diet; Female; Fludrocortisone; Glucocorticoids; Hepatectomy; Hydrocortisone; Liver Regeneration; Male; Mineralocorticoids; Prednisolone; Progesterone; Rats; Sex Factors; Spironolactone; Testosterone | 1973 |
Salivary electrolytes in digitalis-treated patients with and without raised aldosterone excretion.
Topics: Adult; Aged; Aldosterone; Calcium; Digoxin; Female; Heart Failure; Humans; Male; Middle Aged; Potassium; Radioimmunoassay; Saliva; Sodium; Spironolactone | 1973 |
Clinical use of potassium supplements and potassium sparing diuretics.
Topics: Aldosterone; Amiloride; Diuretics; Drug Therapy, Combination; Humans; Hyperkalemia; Hypokalemia; Kidney; Potassium; Spironolactone; Thiazines; Triamterene | 1973 |
The effect of D-aldosterone and spironolactone on the concentration of sodium and potassium in the milk of rats.
Topics: Aldosterone; Animals; Female; Humans; Lactation; Milk; Potassium; Pregnancy; Rats; Sodium; Spironolactone | 1973 |
[Effect of aldosterone and spirolactone on urinary sodium and potassium excretion in newborns and infants (author's transl)].
Topics: Aldosterone; Glomerular Filtration Rate; Humans; Infant; Infant, Newborn; Injections, Intravenous; Natriuresis; Potassium; Spironolactone | 1974 |
Formation and treatment of cerebral edema.
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Acid; Furosemide; Humans; Hyperbaric Oxygenation; Hypotension, Controlled; Injections, Intravenous; Mannitol; Sorbitol; Spironolactone; Time Factors | 1974 |
[Aldosteronism in liver diseases].
Topics: Acute Disease; Aldosterone; Chronic Disease; Humans; Hyperaldosteronism; Liver Diseases; Spironolactone | 1974 |
[Aldosteronism in cardiopulmonary diseases].
Topics: Aldosterone; Edema; Humans; Hyperaldosteronism; Metabolic Clearance Rate; Pulmonary Heart Disease; Spironolactone | 1974 |
Localization of physiological receptor sites for aldosteone in the bladder of the toad, Bufo marinus.
Topics: Aldosterone; Animals; Anura; Binding Sites; Cell Nucleus; Citrates; Desoxycorticosterone; DNA; Glucocorticoids; Hydrocortisone; In Vitro Techniques; Microscopy, Phase-Contrast; Mucous Membrane; Receptors, Drug; Spironolactone; Sucrose; Surface-Active Agents; Urinary Bladder | 1968 |
[Distribution of fluid between the cells and the extracellular media and mineralocorticoid function of the adrenal glands in cardiac insufficiency].
Topics: Adrenal Glands; Adult; Aldosterone; Antipyrine; Body Fluids; Chromatography, Paper; Coronary Disease; Extracellular Space; Female; Heart Failure; Humans; Indicator Dilution Techniques; Male; Methods; Middle Aged; Rheumatic Heart Disease; Spironolactone; Thiosulfates; Water-Electrolyte Balance | 1969 |
[Antikaliuretic agents].
Topics: Adult; Aged; Aldosterone; Chemistry; Diuretics; Female; History, 20th Century; Humans; Hyperaldosteronism; Male; Mineralocorticoid Receptor Antagonists; Potassium; Pyrazines; Spironolactone; Triamterene | 1971 |
Immunosuppressive properties of corticosteroids. I. Aldosterone as immunosuppressant in skin allograts in rats.
Topics: Aldosterone; Animals; Antilymphocyte Serum; Graft Rejection; Immunosuppressive Agents; Mineralocorticoid Receptor Antagonists; Prednisolone; Rabbits; Rats; Rats, Inbred Strains; Skin Transplantation; Spironolactone; Transplantation Immunology; Transplantation, Homologous | 1971 |
Immunosuppressive properties of corticosteroids. II. Interactions of antilymphocyte serum with corticosteroids in adrenalectomized rats.
Topics: Adrenalectomy; Aldosterone; Animals; Antilymphocyte Serum; Graft Rejection; Immunosuppressive Agents; Mineralocorticoid Receptor Antagonists; Prednisolone; Rabbits; Rats; Rats, Inbred Strains; Skin Transplantation; Spironolactone; Transplantation Immunology; Transplantation, Homologous | 1971 |
Hyperkalemic intermittent paralysis associated with spironolactone in a patient with cardiac cirrhosis.
Topics: Acetazolamide; Adult; Aldosterone; Ascites; Female; Furosemide; Heart Failure; Heart Valve Diseases; Humans; Hyperkalemia; Liver Cirrhosis; Paralysis; Rheumatic Diseases; Spironolactone | 1968 |
Experimental studies on the carbonic anhydrase activity. IX. The mode of action of adrenocortical steroids, especially aldosterone, on the carbonic anhydrase in mice and rats.
Topics: Acetazolamide; Adrenal Cortex Hormones; Adrenal Glands; Aldosterone; Animals; Carbonic Anhydrases; Corticosterone; Hydrocortisone; Kidney; Liver; Male; Mice; Pancreas; Rats; Spironolactone | 1967 |
Interactions of spironolactone and hydrochlorothiazide with aspirin in the rat and dog.
Topics: Aldosterone; Animals; Aspirin; Corticosterone; Diuresis; Diuretics; Dogs; Drug Interactions; Female; Hydrochlorothiazide; Kidney; Male; Mineralocorticoids; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone | 1972 |
Aldosterone excess and adrenal carcinoma.
Topics: Adrenal Gland Neoplasms; Aged; Aldosterone; Carcinoma; Humans; Hyperaldosteronism; Spironolactone | 1972 |
Idiopathic edema. II. Pathogenesis of edema in patients with hypoalbuminemia.
Topics: Adrenal Glands; Adult; Aldosterone; Blood Protein Disorders; Body Weight; Creatinine; Edema; Female; Fludrocortisone; Humans; Kidney; Norepinephrine; Plasma Volume; Posture; Renin; Serum Albumin; Sodium; Spironolactone; Sympathetic Nervous System; Water-Electrolyte Balance | 1972 |
Hyporeninemic hypertension.
Topics: Adolescent; Adrenal Glands; Adult; Aged; Aldosterone; Blood Urea Nitrogen; Catecholamines; Diet, Sodium-Restricted; Female; Humans; Hyperaldosteronism; Hypertension; Hypocalcemia; Male; Middle Aged; Posture; Potassium; Renin; Saliva; Sodium; Spironolactone; Time Factors; Vanilmandelic Acid | 1972 |
[Renin and aldosterone regulation in idiopathic edemas].
Topics: Adult; Aldosterone; Edema; Female; Humans; Hyperaldosteronism; Middle Aged; Renin; Spironolactone; Stress, Psychological; Water-Electrolyte Balance | 1972 |
Effect of spironolactone on stool electrolyte losses during human cholera.
Topics: Adult; Aldosterone; Chlorides; Cholera; Diarrhea; Feces; Humans; Male; Potassium; Sodium; Spironolactone; Water-Electrolyte Balance | 1972 |
Primary aldosteronism. Review of diagnostic tests and 15 cases.
Topics: Academic Dissertations as Topic; Adult; Aged; Aldosterone; Diagnosis, Differential; Electrolytes; Evaluation Studies as Topic; Female; Humans; Hyperaldosteronism; Hypertension; Male; Methods; Middle Aged; Potassium; Radioimmunoassay; Renin; Spironolactone | 1972 |
Age dependant determinations of lysosomal enzymes in the liver of spironolactone and aldosterone pretreated rats.
Topics: Age Factors; Aldosterone; Animals; Enzyme Induction; Glucuronidase; Glycoside Hydrolases; Hexosaminidases; Liver; Male; Microscopy, Electron; Rats; Spironolactone | 1972 |
[Mineralocorticoid reaction of hypertensive patients to spirolactone].
Topics: Aldosterone; Blood Pressure; Humans; Hypertension; Metabolic Clearance Rate; Sodium; Spironolactone | 1972 |
[Renal effects of aldosterone and spironolactone in rats f different age].
Topics: Age Factors; Aldosterone; Animals; Diuresis; Female; Hydrogen-Ion Concentration; Kidney Tubules; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone; Time Factors | 1972 |
The effects of aldosterone on renin release in the isolated bloodless perfused canine kidney.
Topics: Aldosterone; Animals; Dogs; Feedback; Glomerular Filtration Rate; Kidney; Methods; Perfusion; Potassium; Regional Blood Flow; Renin; Sodium; Spironolactone; Time Factors | 1972 |
[Electrocardiographic observations in secondary aldosteronism].
Topics: Aged; Aldosterone; Body Weight; Digitalis Glycosides; Diuresis; Electrocardiography; Female; Heart Failure; Humans; Hyperaldosteronism; Hypokalemia; Mineralocorticoid Receptor Antagonists; Myocardium; Potassium; Spironolactone | 1972 |
Fluid uptake from intestine of the euryhaline frog, Rana cancrivora, as affected by the salinity of the environment.
Topics: Aldosterone; Animals; Anura; Fresh Water; In Vitro Techniques; Intestinal Absorption; Osmolar Concentration; Pituitary Hormones, Posterior; Ranidae; Sodium Chloride; Spironolactone; Water | 1972 |
The action of aldosterone on transepithelial sodium transport in isolated ventral toad skin.
Topics: Aldosterone; Animals; Anura; Biological Transport, Active; Cycloheximide; Dactinomycin; Depression, Chemical; Electrophysiology; Glucose; Hexoses; In Vitro Techniques; Ouabain; Skin Physiological Phenomena; Sodium; Spironolactone; Stimulation, Chemical | 1971 |
Erythrocyte function and aldosterone.
Topics: Adrenalectomy; Aldosterone; Animals; Elasticity; Erythrocytes; Hematocrit; Heparin; Humans; Hyperaldosteronism; In Vitro Techniques; Oxygen; Oxygen Consumption; Sheep; Spironolactone | 1971 |
[Digoxin incorporation into the cell].
Topics: Aldosterone; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Digitoxin; Digoxin; In Vitro Techniques; Mice; Prednisolone; Spironolactone; Thyroid Hormones; Tritium | 1971 |
Hypertension and low plasma renin activity: presumptive evidence for mineralocorticoid excess.
Topics: Adrenal Glands; Aldosterone; Blood Pressure; Body Weight; Carbon Dioxide; Chlorides; Female; Humans; Hypertension; Male; Mineralocorticoids; Posture; Potassium; Pregnancy; Renin; Sodium; Spironolactone | 1971 |
Effects of an aldosterone antagonist, spironolactone, on pinealectomized rats.
Topics: Adrenal Glands; Aldosterone; Animals; Arteries; Blood Pressure; Epinephrine; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Norepinephrine; Pineal Gland; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1971 |
The influence of aldosterone on renin release in the isolated canine kidney perfused with ascitic fluid.
Topics: Aldosterone; Animals; Ascitic Fluid; Dogs; Feedback; In Vitro Techniques; Kidney; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 1971 |
[Sodium balance during fasting and realimentation with special reference to a form of therapy for obesity].
Topics: Aldosterone; Diet, Sodium-Restricted; Fasting; Food; Glucose Tolerance Test; Humans; Insulin; Ketones; Natriuresis; Obesity; Osmolar Concentration; Sodium; Spironolactone; Water-Electrolyte Balance | 1971 |
Edema and increased plasma renin activity in lithium treated patients.
Topics: Adult; Affective Symptoms; Aldosterone; Anxiety; Bipolar Disorder; Carbonates; Chlorpromazine; Diet; Edema; Female; Humans; Lithium; Male; Middle Aged; Renin; Sodium; Sodium Chloride; Spironolactone | 1971 |
[Primary hyperaldosteronism: differentiation between adenoma and primary hyperplasia of the adrenal glands and operative indications].
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Dexamethasone; Diagnosis, Differential; Humans; Hyperaldosteronism; Hyperplasia; Phlebography; Potassium; Saliva; Spironolactone | 1971 |
Studies of the antidiuresis induced by natrichloriuretic drugs in rats with diabetes insipidus.
Topics: Aldosterone; Animals; Bendroflumethiazide; Desoxycorticosterone; Diabetes Insipidus; Diuresis; Female; Hypothalamus; Ketones; Natriuresis; Pyrimidines; Rats; Spironolactone; Triamterene; Water-Electrolyte Balance | 1966 |
Aldosterone antagonists and triamterene.
Topics: Aldosterone; Humans; Hyperaldosteronism; Natriuresis; Potassium; Spironolactone; Triamterene | 1966 |
The use of glucocorticoids for diuresis in patients with fluid retention not resulting from renal disease.
Topics: Aldosterone; Chlorothiazide; Diuresis; Edema; Glomerular Filtration Rate; Glucocorticoids; Heart Diseases; Humans; Liver Cirrhosis; Mannitol; Methylprednisolone; Natriuresis; Organomercury Compounds; Potassium; Sodium; Spironolactone | 1966 |
Role of aldosterone in myocardial infarction.
Topics: Adult; Aldosterone; Animals; Chromatography; Diet, Sodium-Restricted; Dogs; Humans; Male; Myocardial Infarction; Posture; Potassium; Sodium; Spironolactone | 1965 |
The effects of aldosterone and spirolactone on renal sodium and potassium excretion during mannitol diuresis.
Topics: Aldosterone; Alkalies; Animals; Chronic Disease; Diuresis; Dogs; Female; Humans; Injections, Intravenous; Mannitol; Nephritis; Potassium; Sodium; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1968 |
[Aldosterone and sodium excretion in pregnancy].
Topics: Aldosterone; Aminohippuric Acids; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney Tubules; Potassium; Pregnancy; Sodium; Spironolactone | 1971 |
[Influence of spironolactone on the excretion of C21-, C19-, and C18 steroids in pregnant and nonpregnant women].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aldosterone; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Pregnancy; Pregnanediol; Spironolactone | 1971 |
Effects of ouabain on the tissue distribution and metabolism of 3H-1,2-d-aldosterone.
Topics: Adipose Tissue; Aldosterone; Animals; Bile; Brain Chemistry; Diet; Intestine, Small; Liver; Lung; Male; Muscles; Myocardium; Ouabain; Rats; Sodium; Spironolactone; Spleen; Time Factors; Tritium | 1969 |
Effect of spironolactone on the zona. Light and electron microscopy.
Topics: Adolescent; Adrenal Glands; Adult; Aged; Aldosterone; Autopsy; Child; Child, Preschool; Cytoplasm; Endoplasmic Reticulum; Female; Histocytochemistry; Humans; Infant; Infant, Newborn; Lipoproteins; Male; Microscopy; Microscopy, Electron; Middle Aged; Mitochondria; Phospholipids; Spironolactone | 1969 |
Diuretic responses to electrolyte loads in four strains of mice.
Topics: Adrenal Glands; Aldosterone; Animals; Diuresis; Male; Mice; Natriuresis; Potassium Chloride; Sodium Chloride; Species Specificity; Spironolactone; Time Factors; Vasopressins; Water-Electrolyte Balance | 1969 |
[Treatment of secondary hyperaldosteronism].
Topics: Adrenalectomy; Aldosterone; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Diuretics; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Pyridones; Spironolactone; Triamterene | 1969 |
Hypertension and hyperaldosteronism with low plasma renin concentration: analysis of a series of eighty-two patients.
Topics: Adrenal Glands; Aldosterone; Body Weight; Humans; Hyperaldosteronism; Hypertension; Plasma Volume; Potassium; Renin; Secretory Rate; Sodium; Spironolactone | 1969 |
Macromolecular binding of aldosterone in the toad bladder.
Topics: Alcohols; Aldosterone; Animals; Anura; Binding Sites; Cell Nucleus; Chromatography, Gel; Cytoplasm; Deoxyribonucleases; Depression, Chemical; Desoxycorticosterone; DNA; Glycerol; Hydrocortisone; In Vitro Techniques; Macromolecular Substances; Methods; Mineralocorticoid Receptor Antagonists; Molecular Weight; Mucous Membrane; Polysaccharides; Protein Binding; Proteins; Ribonucleases; Solubility; Spironolactone; Stimulation, Chemical; Sulfur; Temperature; Testosterone; Tritium; Urinary Bladder; Vibration | 1969 |
Suppressed plasma renin activity in in hypertensive patients--its evaluation for the diagnosis of primary aldosteronism.
Topics: Aldosterone; Cushing Syndrome; Diet, Sodium-Restricted; Glomerulonephritis; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney Neoplasms; Metabolic Diseases; Mixed Function Oxygenases; Pyelonephritis; Renin; Spironolactone; Stimulation, Chemical; Time Factors | 1969 |
[Induced aldosteronism in hydropic heart insufficiency].
Topics: Acid-Base Equilibrium; Adult; Aged; Aldosterone; Body Weight; Carbon Isotopes; Cardiac Glycosides; Electrolytes; Female; Heart Failure; Heart Valve Diseases; Humans; Hyperaldosteronism; Male; Middle Aged; Sodium; Spironolactone; Tritium | 1969 |
[Effect of hormones on physical and chemical properties of connective- and supporting tissue. 1].
Topics: Acetates; Adrenalectomy; Age Factors; Aldosterone; Animals; Body Weight; Connective Tissue; Corticosterone; Depression, Chemical; Desoxycorticosterone; Dihydrotachysterol; Epiphyses; Estradiol; Female; Femur; Guinea Pigs; Hormones; Hydrocortisone; Male; Mice; Prednisolone; Progesterone; Rabbits; Rats; Sex Factors; Spironolactone; Stimulation, Chemical; Stress, Physiological; Succinates; Tail; Tendons; Testosterone | 1969 |
[Primary aldosteronism and its surgical treatment].
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Child; Female; Humans; Hyperaldosteronism; Hyperplasia; Male; Middle Aged; Renin; Spironolactone | 1970 |
The syndrome of primary aldosteronism.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorides; Chromium; Corticosterone; Diet; Female; Humans; Hydrogen-Ion Concentration; Hyperaldosteronism; Hyperplasia; Male; Middle Aged; Potassium; Sodium; Spironolactone; Triamterene; Urine | 1970 |
Drug-induced secondary hyperaldosteronism in patients with pulmonary tuberculosis.
Topics: Adult; Aldosterone; Female; Gentamicins; Humans; Hyperaldosteronism; Hypokalemia; Magnesium; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Tuberculosis, Pulmonary | 1970 |
[Treatment of an autoimmune disease of the eye with antilymphocyte serum combined with prednisolone, azathioprine, aldosterone and spironolactone].
Topics: Aldosterone; Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Child; Humans; Immunosuppressive Agents; Leukocyte Count; Lymphocyte Activation; Male; Ophthalmia, Sympathetic; Prednisolone; Spironolactone | 1970 |
Stereospecific binding of aldosterone to renal chromatin.
Topics: Aldosterone; Animals; Binding Sites; Centrifugation, Density Gradient; Chymotrypsin; Dactinomycin; Deoxyribonucleases; Drug Stability; Estradiol; Fludrocortisone; Glycerol; Hydrocortisone; Kidney; Male; Metabolism; Mineralocorticoids; Nucleoproteins; Progesterone; Protein Binding; Rats; Ribonucleases; Spironolactone; Tritium; Trypsin | 1970 |
[1st results of the use of Soludactone in the treatment of certain forms of cerebral edema].
Topics: Adolescent; Adult; Aged; Aldosterone; Brain Edema; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Spironolactone | 1970 |
Spironolactone diuresis in patients with cirrhosis and ascites.
Topics: Alcoholism; Aldosterone; Ascites; Humans; Liver Cirrhosis; Potassium; Sodium; Spironolactone | 1970 |
Mineralocorticoids and sweat gland function.
Topics: Adrenal Glands; Adult; Aldosterone; Desoxycorticosterone; Diuresis; Fasting; Hot Temperature; Humans; Kidney; Male; Mineralocorticoids; Potassium; Sodium; Spironolactone; Sweat; Sweat Glands; Sweating; Water-Electrolyte Balance | 1970 |
Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction.
Topics: Aldosterone; Ammonia; Bicarbonates; Blood Urea Nitrogen; Child; Chlorides; Creatinine; Diet, Sodium-Restricted; Female; Humans; Hydrogen-Ion Concentration; Hyperkalemia; Hypertension; Natriuresis; Potassium; Renin; Sodium; Spironolactone | 1970 |
The effect of the spirolactone SC 14266 on the sodium transport across isolated frogskin.
Topics: Aldosterone; Animals; Anura; Biological Transport; In Vitro Techniques; Skin; Sodium; Spironolactone | 1970 |
The effect of spironolactone on sodium transport in the absence of aldosterone.
Topics: Aldosterone; Animals; Ascites; Biological Transport; Carcinoma; Depression, Chemical; Erythrocytes; Humans; In Vitro Techniques; Laryngeal Neoplasms; Mice; Neoplasms, Experimental; Potassium; Sodium; Spironolactone | 1970 |
Pretibial edema and sodium retention during lithium carbonate treatment.
Topics: Adult; Age Factors; Aldosterone; Bipolar Disorder; Body Weight; Carbonates; Diet; Edema; Female; Humans; Kidney Tubules; Lithium; Male; Middle Aged; Sodium; Spironolactone; Tibia | 1970 |
Effects of aldosterone and cortisol on human erythrocyte Na efflux.
Topics: Aldosterone; Biological Transport, Active; Cushing Syndrome; Erythrocytes; Humans; Hydrocortisone; Hyperaldosteronism; In Vitro Techniques; Potassium; Renin; Secretory Rate; Sodium; Sodium Isotopes; Spironolactone; Stimulation, Chemical | 1971 |
Erythrocyte Na flux in a patient with Bartter's syndrome.
Topics: Aldosterone; Alkalosis; Ammonium Chloride; Biological Transport; Biological Transport, Active; Cell Membrane; Child; Chlorides; Erythrocytes; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Juxtaglomerular Apparatus; Kidney Diseases; Male; Potassium; Renin; Secretory Rate; Sodium; Sodium Isotopes; Spironolactone | 1971 |
[Treatment of late pregnancy toxemias with aldactone].
Topics: Adolescent; Adult; Aldosterone; Colorimetry; Female; Humans; Potassium; Pre-Eclampsia; Pregnancy; Sodium; Spectrophotometry; Spironolactone | 1971 |
Relationship of cardiorenal function to renin-aldosterone system in patients with valvular heart disease.
Topics: Aldosterone; Blood Pressure; Cardiac Volume; Diuretics; Heart; Heart Valve Diseases; Kidney; Natriuresis; Potassium; Renin; Sodium; Spironolactone | 1971 |
[Endocrinologic and circulatory findings in a case of primary aldosteronism].
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Female; Hemodynamics; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Middle Aged; Renin; Spironolactone | 1971 |
Experimental production of so-called spironolactone bodies.
Topics: Adrenal Glands; Aldosterone; Animals; Cytoplasmic Granules; Female; Lipids; Male; Microscopy, Electron; Microtubules; Mitochondria; Organoids; Rats; Spironolactone | 1971 |
Low-renin essential hypertension--another form of childhood hypertension.
Topics: Aldosterone; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypertension; Infant; Infant, Newborn; Mineralocorticoids; Potassium; Renin; Saliva; Sodium; Spironolactone | 1971 |
Urinary citrate excretion in primary aldosteronism.
Topics: Addison Disease; Adult; Aldosterone; Carbon Dioxide; Citrates; Desoxycorticosterone; Dexamethasone; Female; Humans; Hyperaldosteronism; Hypokalemia; Male; Middle Aged; Potassium; Potassium Chloride; Spironolactone | 1967 |
[Clinical studies on the urinary excretion of aldosterone in myasthenia gravis].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aldosterone; Ambenonium Chloride; Catecholamines; Chromatography; Chromatography, Paper; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Norethindrone; Potassium; Sodium; Spectrum Analysis; Spironolactone; Triamterene | 1967 |
Amiloride. A potassium-sparing natriuretic agent.
Topics: Acetazolamide; Aldosterone; Ammonia; Ascites; Bicarbonates; Blood Pressure; Chlorides; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; Hydrogen-Ion Concentration; Liver Cirrhosis; Male; Natriuresis; Organomercury Compounds; Potassium; Renin; Sodium; Spironolactone | 1968 |
Unilateral adrenalectomy for aldosteronomas localized preoperatively by differential adrenal vein catheterization.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Angiography; Aortography; Blood Pressure; Catheterization; Female; Humans; Hyperaldosteronism; Hypertension; Male; Methods; Phlebography; Potassium; Renin; Spironolactone | 1968 |
Primary aldosteronism.
Topics: Aldosterone; Blood Pressure; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 1968 |
In vitro inhibition of aldosterone-stimulated sodium transport by steroidal spirolactones.
Topics: Aldosterone; Animals; Anura; Biological Transport; Electrophysiology; Glucose; In Vitro Techniques; Kinetics; Mineralocorticoid Receptor Antagonists; Receptors, Drug; Sodium; Spironolactone; Urinary Bladder; Vasopressins | 1968 |
Aldosteronism in hypertension. The spironolactone response test.
Topics: Adrenalectomy; Aldosterone; Blood Pressure; Body Weight; Diagnosis, Differential; Electrolytes; Humans; Hyperaldosteronism; Hypertension; Renin; Spironolactone | 1968 |
Mode of spirolactone action: competitive inhibition of aldosterone binding to kidney mineralocorticoid receptors.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Cell Nucleus; Depression, Chemical; Kidney; Microsomes; Mitochondria; Rats; Receptors, Drug; Spironolactone; Tritium | 1968 |
Metabolic studies on hypertensive patients with suppressed plasma renin activity not due to hyperaldosternosm.
Topics: Adult; Aldosterone; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Blood Volume; Body Weight; Electrolytes; Female; Glucose Tolerance Test; Humans; Hypertension; Hypertension, Renal; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone | 1968 |
[A case of juvenile arterial hypertension associated with hypokalemia and low aldosterone secretion (Liddle syndrome)].
Topics: Adolescent; Aldosterone; Female; Humans; Hypertension; Hypokalemia; Spironolactone; Triamterene | 1968 |
[Renin studies in idiopathic edemas with secondary hyperaldosteronism].
Topics: Adolescent; Adult; Aldosterone; Dextrans; Edema; Female; Humans; Hyperaldosteronism; Infusions, Parenteral; Natriuresis; Plasma Volume; Renin; Spironolactone | 1968 |
[Diuretic action of prednisolone and aldactone].
Topics: Adolescent; Aldosterone; Child; Child, Preschool; Diuresis; Humans; Hyaluronoglucosaminidase; Infant; Kidney Function Tests; Prednisolone; Spironolactone | 1968 |
[Kidney artery stenosis, renal hypertension and secondary hyperaldosteronism in an 8-year-old boy. (Stunted growth through potassium deficiency)].
Topics: Adrenal Glands; Aldosterone; Child; Dwarfism; Humans; Hyperaldosteronism; Hypertension, Renal; Hypokalemia; Ischemia; Kidney; Kidney Diseases; Male; Microscopy, Electron; Mitochondria; Nephrectomy; Potassium; Potassium Deficiency; Proteinuria; Renal Artery Obstruction; Spironolactone | 1968 |
Site of action of aldactone A in the nephron during dietary sodium restriction in men.
Topics: Absorption; Adult; Aldosterone; Diet, Sodium-Restricted; Diuresis; Female; Humans; Hydrogen-Ion Concentration; Kidney Tubules; Male; Middle Aged; Potassium; Sodium; Spironolactone; Urine; Water; Water-Electrolyte Balance | 1968 |
[Effect of corticoids on the survival of animals irradiated with supralethal doses].
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Cortisone; Glucocorticoids; Male; Mineralocorticoids; Radiation Injuries, Experimental; Rats; Spironolactone | 1968 |
[Hyperaldosteronism and the use of aldactone in cardiac insufficiency].
Topics: Adult; Aldosterone; Blood Flow Velocity; Blood Volume; Cardiac Output; Diuresis; Female; Heart Failure; Humans; Hyperaldosteronism; Male; Methods; Middle Aged; Potassium; Sodium; Spironolactone; Water-Electrolyte Balance | 1968 |
Periodic paralysis associated with hyperthyroidism. Study of the precipitating factors.
Topics: Adult; Aldosterone; Familial Mediterranean Fever; Glucose Tolerance Test; Humans; Hyperthyroidism; Insulin; Male; Middle Aged; Paralysis; Potassium; Sodium Chloride; Spironolactone | 1968 |
Test for pathologic secretion of aldosterone.
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Diet; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Methods; Postoperative Complications; Potassium; Renal Artery Obstruction; Spironolactone | 1968 |
Estimation of plasma potassium, renin and aldosterone in the diagnosis of primary hyperaldosteronism; the role of spironolactone in the treatment of this syndrome.
Topics: Aldosterone; Humans; Hyperaldosteronism; Potassium; Renin; Serologic Tests; Spironolactone | 1969 |
Aldosteronism and spironolactone.
Topics: Aldosterone; Humans; Hyperaldosteronism; Renin; Spironolactone | 1969 |
Aldosterone and spironolactone.
Topics: Aldosterone; Humans; Hyperaldosteronism; Renin; Spironolactone | 1969 |
Effect of adrenal steroid hormones on the response of the toad's urinary bladder to vasopressin.
Topics: Aldosterone; Animals; Anura; Biological Transport; Carbon Isotopes; Chlorides; Corticosterone; Desoxycorticosterone; Dexamethasone; Glucose; Potassium; Sodium; Spironolactone; Urinary Bladder; Vasopressins; Water | 1969 |
[On the pathogenesis of the changes in water, sodium, and potassium metabolism caused by fasting in obese women].
Topics: Aldosterone; Diet; Fasting; Female; Humans; Obesity; Potassium; Sodium; Spironolactone; Water-Electrolyte Balance | 1969 |
[Influence of aldosterone on the exchange and outflow in the human organism of minerals and trace elements relevant to occupational medicine].
Topics: Adolescent; Adult; Aldosterone; Calcium; Humans; Lead; Magnesium; Male; Occupational Medicine; Spectrophotometry; Spironolactone; Trace Elements; Zinc | 1969 |
Non-tumorous "primary" aldosteronism: II. Type not relieved by glucocorticoid.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Blood Pressure; Corticosterone; Desoxycorticosterone; Dexamethasone; Diet; Glucocorticoids; Humans; Hyperaldosteronism; Kidney Function Tests; Male; Middle Aged; Potassium; Secretory Rate; Spironolactone; Water-Electrolyte Balance | 1969 |
Non-tumorous "primary" aldosteronism. I. Type relieved by glucocorticoid (glucocorticoid-remediable aldosteronism).
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenalectomy; Adult; Aldosterone; Androgens; Child; Desoxycorticosterone; Dexamethasone; Diet; Estrogens; Female; Follow-Up Studies; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Prednisone; Renin; Secretory Rate; Sodium; Spironolactone | 1969 |
The effect of aldosterone on the electrical activity of rat colon.
Topics: Adrenalectomy; Aldosterone; Anesthesia, Intravenous; Animals; Colon; Cortisone; Electrophysiology; Injections, Intravenous; Mucous Membrane; Ouabain; Pentobarbital; Rats; Sodium; Spironolactone | 1969 |
Plasma renin activity in the diagnosis of primary aldosteronism: failure to distinguish primary aldosteronism from essential hypertension.
Topics: Adrenal Gland Neoplasms; Adult; Aldosterone; Animals; Biological Assay; Blood Urea Nitrogen; Chlorothiazide; Creatinine; Diagnosis, Differential; Diet; Extracellular Space; Female; Furosemide; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Juxtaglomerular Apparatus; Male; Middle Aged; Plasma Volume; Posture; Potassium; Rats; Renin; Sodium; Spironolactone; Vanilmandelic Acid | 1969 |
Clinical studies on the acid-base balance disturbance in congestive heart failure.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Adult; Aldosterone; Alkalosis; Arteries; Benzothiadiazines; Carbon Dioxide; Carbonates; Chlorides; Digitalis Glycosides; Diuretics; Female; Furosemide; Heart Failure; Heart Valve Diseases; Humans; Hydrogen-Ion Concentration; Hypokalemia; Male; Middle Aged; Oxygen; Potassium; Sodium; Spironolactone; Trichlormethiazide | 1969 |
[Therapeutically induced aldosteronism in hydropic cardiac insufficiency].
Topics: Aldosterone; Carbon Isotopes; Cardiac Glycosides; Diuretics; Heart Failure; Humans; Hyperaldosteronism; Metabolic Clearance Rate; Methods; Secretory Rate; Spironolactone; Tritium | 1969 |
The effect of adrenal steroids on stool composition, as revealed by in vivo dialysis of faeces.
Topics: Adult; Aldosterone; Depression, Chemical; Dialysis; Feces; Female; Fludrocortisone; Humans; Hydrocortisone; Hyperaldosteronism; Male; Methods; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone; Stimulation, Chemical | 1969 |
Effect of spironolactone on experimental renovascular hypertension.
Topics: Aldosterone; Animals; Hypertension, Renal; Rats; Spironolactone | 1965 |
A study of feedback in aldosterone secretion.
Topics: Adrenal Glands; Aldosterone; Animals; Blood; Feedback; Parotid Gland; Sheep; Sodium; Spironolactone | 1965 |
N-amidino-3-amino-6-chloropyrazinecarboxamide: a new diuretic which antagonizes the renal actions of aldosterone.
Topics: Aldosterone; Animals; Desoxycorticosterone; Diuretics; Hydrocortisone; Kidney; Natriuresis; Potassium; Rats; Spironolactone; Triamterene; Urine | 1965 |
[Effects of spirolactone in some cases of obesity (study of 53 cases)].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Aldosterone; Female; Humans; Middle Aged; Obesity; Spironolactone | 1965 |
[On the effect of aldosterone and aldactone A on various segments of kidney tubules in Cushing's syndrome with polyuria].
Topics: Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Kidney Tubules; Polyuria; Potassium; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1965 |
[Secondary aldosteronism following surgery using the heart-lung machine and its regulation with Aldactone].
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aldosterone; Alkalosis; Cardiac Surgical Procedures; Child; Extracorporeal Circulation; Humans; Hyperaldosteronism; Spironolactone; Water-Electrolyte Balance | 1965 |
[On the type and importance of corticosteroid-cardenolide antagonism for electrolyte transport in the rat kidney].
Topics: Adrenalectomy; Aldosterone; Animals; Glycosides; Kidney; Natriuresis; Plants, Medicinal; Potassium; Rats; Sodium; Spironolactone | 1965 |
The role of aldosterone and vasopressin in the postural changes in renal excretion in normal subjects and patients with idiopathic edema.
Topics: Addison Disease; Adolescent; Adrenalectomy; Adult; Aldosterone; Creatine; Dextroamphetamine; Diabetes Insipidus; Edema; Ethanol; Female; Humans; Kidney Tubules; Middle Aged; Natriuresis; Posture; Spironolactone; Vasopressins | 1966 |
Studies on the binding of aldosterone in the toad bladder.
Topics: Aldosterone; Animals; Anura; Biological Transport, Active; Cholesterol; Desoxycorticosterone; Hydrocortisone; In Vitro Techniques; Progesterone; Radiometry; Sodium; Spironolactone; Tritium; Urinary Bladder | 1966 |
The action of exogenous aldosterone on the secretion and composition of drug-induced sweat.
Topics: Aldosterone; Humans; Male; Methacholine Compounds; Potassium; Sodium; Spironolactone; Sweat; Sweat Glands; Urine | 1966 |
Blocking by spironolactone (SC 9420) of the action of aldosterone upon the intestinal transport of potassium, sodium, and water.
Topics: Aldosterone; Animals; Biological Transport; Dogs; Intestinal Mucosa; Potassium; Sodium; Spironolactone; Water-Electrolyte Balance | 1966 |
N-Amidino-3,5-diamino-6-chloropyrazine-carboxamide: an active diuretic in the carboxamide series.
Topics: Adrenalectomy; Aldosterone; Amides; Amidines; Animals; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Hydrocortisone; Male; Potassium; Pyrazines; Rats; Sodium; Spironolactone; Sulfhydryl Compounds | 1966 |
Studies in familial hypokalaemic periodic paralysis.
Topics: Adult; Aldosterone; Blood Chemical Analysis; Chlorides; Diet, Sodium-Restricted; Diuresis; Electrolytes; Humans; Hydrogen-Ion Concentration; Hypokalemia; Male; Muscles; Paralyses, Familial Periodic; Potassium; Secretory Rate; Sodium; Spironolactone; Triamterene; Urine; Water; Water-Electrolyte Balance | 1966 |
[On the management of postoperative motility of the intestines by aldosterone antagonists].
Topics: Aldosterone; Gastrointestinal Motility; Humans; Postoperative Complications; Potassium Deficiency; Preoperative Care; Spironolactone | 1966 |
The effects of exogenous aldosterone on sweat electrolytes. I. Normal subjects.
Topics: Adolescent; Adult; Aldosterone; Body Weight; Child; Female; Humans; Iontophoresis; Kidney; Male; Pilocarpine; Potassium; Sodium; Spironolactone; Sweat; Sweat Glands | 1967 |
Bilateral adrenal hyperplasia as a cause of primary aldosteronism with hypertension, hypokalemia and suppressed renin activity.
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Glands; Aldosterone; Blood Urea Nitrogen; Carbon Dioxide; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Middle Aged; Natriuresis; Phenethylamines; Potassium; Renin; Sodium; Spironolactone | 1967 |
An azido pyrimidine diuretic (SC-16102): reversal of the Na retention induced by aldosterone.
Topics: Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Male; Natriuresis; Potassium; Pyrimidines; Rats; Spironolactone | 1967 |
Diuretics.
Topics: Aldosterone; Ascites; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans; Organomercury Compounds; Pteridines; Spironolactone | 1967 |
The proper use of newer diuretics.
Topics: Aldosterone; Carbonic Anhydrase Inhibitors; Chlorothiazide; Diuresis; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans; Natriuresis; Spironolactone; Triamterene; Water-Electrolyte Balance | 1967 |
Excretion of different substances in the sweat of children with cystic fibrosis and controls.
Topics: Aldosterone; Calcium; Child; Chlorides; Creatinine; Cystic Fibrosis; Humans; Lactates; Male; Sodium; Spironolactone; Sweat; Sweating; Urea | 1967 |
Isolated analdosteronism. 3. The ability of aldosterone antagonists to alter electrolyte balance in the absence of a potent mineralocorticoid.
Topics: Aldosterone; Chlorides; Humans; Hydroxyprogesterones; Mineralocorticoid Receptor Antagonists; Potassium; Progesterone; Sodium; Spironolactone; Water-Electrolyte Balance | 1967 |
The effect of aldosterone and adrenalectomy on the electrical potential difference of rat colon and on the transport of sodium, potassium, chloride and bicarbonate.
Topics: Adrenalectomy; Aldosterone; Animals; Bicarbonates; Biological Transport; Chlorides; Colon; Electrophysiology; Feces; Hydrocortisone; Male; Photometry; Potassium; Rats; Sodium; Spironolactone; Water | 1967 |
Impaired conservation of sodium and potassium in renal tubular acidosis and its correction by buffer anions.
Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adolescent; Adult; Aldosterone; Bicarbonates; Body Weight; Buffers; Child; Female; Humans; Hydrogen-Ion Concentration; Male; Phosphates; Potassium; Sodium; Spironolactone | 1967 |
In vitro responses of aldosterone-producing adenomas to angiotensin II and ACTH after treatment with spironolactone before adrenalectomy.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Combined Modality Therapy; Humans; Hyperaldosteronism; In Vitro Techniques; Potassium; Spironolactone; Time Factors | 1984 |
Effect of spironolactone on electrolytes, renin, ACTH and corticosteroids in the rat.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Diet; Diet, Sodium-Restricted; Feces; Male; Potassium; Rats; Rats, Inbred Strains; Renin; Sodium; Spironolactone | 1984 |
The effect of long-term treatment with spironolactone on sodium pump abnormalities in the red blood cells of patients with Bartter's syndrome.
Topics: Adult; Aldosterone; Bartter Syndrome; Erythrocytes; Humans; Hyperaldosteronism; Ion Channels; Potassium; Radioisotopes; Renin; Rubidium; Sodium; Spironolactone; Time Factors | 1984 |
Corticosteroids and the active ion transport of the isolated human lens.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Electrophysiology; Humans; In Vitro Techniques; Ion Channels; Lens, Crystalline; Methylprednisolone; Ouabain; Rabbits; Spironolactone | 1984 |
[Prevention of brain edema. After acute hypertonic dehydration by dexamethasone, aldosterone and spirolactone during rehydration].
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Chemistry; Brain Edema; Desiccation; Dexamethasone; Potassium; Rabbits; Sodium; Spironolactone; Water | 1981 |
Short-term effects of aldosterone and dexamethasone on Na-K-ATPase along the rabbit nephron.
Topics: Adenosine Triphosphatases; Adrenalectomy; Aldosterone; Animals; Ca(2+) Mg(2+)-ATPase; Dexamethasone; Male; Nephrons; Rabbits; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1983 |
Pharmacology of the steroid regulation of transmitter choice in cultured rat sympathetic ganglia.
Topics: Aldosterone; Androstanols; Animals; Choline O-Acetyltransferase; Corticosterone; Cortodoxone; Ganglia, Sympathetic; Progesterone; Rats; Rats, Inbred Strains; Spironolactone; Tyrosine 3-Monooxygenase | 1984 |
Binding and antimineralocorticoid activities of spirolactones in toad bladder.
Topics: Aldosterone; Animals; Binding, Competitive; Biological Transport; Bufo marinus; Female; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Sodium; Spironolactone; Urinary Bladder | 1983 |
Structure-activity relationship of new steroidal aldosterone antagonists. Comparison of the affinity for mineralocorticoid receptors in vitro and the antialdosterone activity in vivo.
Topics: Aldosterone; Animals; Binding, Competitive; Cytosol; Kidney; Male; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Receptors, Steroid; Spironolactone | 1983 |
Characterization of spironolactone binding sites distinct from aldosterone receptors in rat kidney homogenates.
Topics: Aldosterone; Animals; Binding, Competitive; In Vitro Techniques; Kidney; Male; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Temperature | 1984 |
Aldosterone and dopamine receptors in the kidney: sites for pharmacologic manipulation of renal function.
Topics: Aldosterone; Animals; Dopamine; Fludrocortisone; Fluprednisolone; Glycyrrhiza; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Plant Extracts; Plants, Medicinal; Receptors, Cell Surface; Receptors, Dopamine; Spironolactone | 1980 |
Effect of spironolactone administration on plasma and urinary aldosterone in man and the rat.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Corticosterone; Humans; Hydrocortisone; Male; Rats; Renin; Species Specificity; Spironolactone | 1980 |
Plasma corticosteroid concentrations during spironolactone administration: evidence for adrenal biosynthetic blockade in man.
Topics: 18-Hydroxycorticosterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldosterone; Desoxycorticosterone; Female; Humans; Kinetics; Male; Potassium; Progesterone; Renin; Sodium; Spironolactone | 1981 |
Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aldosterone; Aminoglutethimide; Child, Preschool; Dexamethasone; Female; Humans; Hyperaldosteronism; Hypertension; Kinetics; Pregnancy; Renin; Spironolactone | 1981 |
Secondary effect of aldosterone on Na-KATPase activity in the rabbit cortical collecting tubule.
Topics: Adrenalectomy; Aldosterone; Amiloride; Animals; Biological Transport; Dexamethasone; Female; Kidney Cortex; Kidney Tubules; Kidney Tubules, Collecting; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Time Factors | 1981 |
Effect of aldosterone antagonists on mineralocorticoid synthesis in vitro. Inhibition of aldosterone production by prorenoate-K.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; In Vitro Techniques; Mineralocorticoid Receptor Antagonists; Pituitary-Adrenal Function Tests; Rana ridibunda; Spironolactone | 1982 |
The mechanism of mineralocorticoid action of carbenoxolone.
Topics: Adrenalectomy; Aldosterone; Animals; Carbenoxolone; Drug Interactions; Female; Glycyrrhetinic Acid; Kidney; Mineralocorticoids; Potassium; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Sodium; Spironolactone | 1982 |
Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Benzothiadiazines; Dexamethasone; Diuretics; Humans; Hydrocortisone; Hyperaldosteronism; Potassium Chloride; Renin; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene | 1982 |
Metabolic and blood pressure responses to hydrocortisone in the syndrome of apparent mineralocorticoid excess.
Topics: Adrenocorticotropic Hormone; Aldosterone; Blood Pressure; Child; Female; Humans; Hydrocortisone; Hydroxysteroids; Hypertension; Metyrapone; Mineralocorticoids; Potassium; Renin; Spironolactone; Syndrome | 1983 |
Aldosterone: a telling case of fruitful interplay between biological and clinical research.
Topics: Adult; Aldosterone; Amphibians; Animals; Biological Transport; Humans; Ion Channels; Male; Nephrons; Sodium; Spironolactone | 1982 |
[Direct action of mineralocorticoid antagonists on biosynthesis of aldosterone: comparative activities of several new compounds].
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnenes; Ranidae; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Veratrum Alkaloids | 1983 |
Aldosterone escape to chronic ACTH administration in man.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Diet, Sodium-Restricted; Humans; Hydrocortisone; Male; Renin; Renin-Angiotensin System; Sodium; Spironolactone; Triamterene | 1983 |
Metabolic regulation of apical sodium permeability in toad urinary bladder in the presence and absence of aldosterone.
Topics: Aldosterone; Animals; Biological Transport; Bufo marinus; Calcium; Cell Membrane Permeability; Cycloheximide; Deoxyglucose; Energy Metabolism; Ion Channels; Male; Oxythiamine; Pyruvates; Pyruvic Acid; Sodium; Spironolactone; Urinary Bladder | 1983 |
[Drug treatment of brain edema].
Topics: Adrenocorticotropic Hormone; Aldosterone; Barbiturates; Blood-Brain Barrier; Brain Edema; Cerebrovascular Circulation; Diuretics; Glucocorticoids; Humans; Hypertonic Solutions; Intracranial Pressure; Molecular Weight; Spironolactone; Tromethamine; Water-Electrolyte Balance | 1983 |
Inhibition of corticotropin release in vitro by dexamethasone, aldosterone and spironolactone.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Cells, Cultured; Dexamethasone; Drug Interactions; Male; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Inbred F344; Spironolactone | 1983 |
Mineralocorticoid receptors in the epithelial cells of human colon and ileum.
Topics: Aldosterone; Binding, Competitive; Cold Temperature; Colon; Dexamethasone; Dihydrotestosterone; Epithelium; Estradiol; Female; Humans; Ileum; Kinetics; Male; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1984 |
The effect of the antimineralocorticoid RU 28318 on aldosterone biosynthesis in vitro.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Kinetics; Rana ridibunda; Spironolactone; Time Factors | 1984 |
Effect of steroids on ACTH release from cultured pituitary cells of the rat.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Cells, Cultured; Dexamethasone; Male; Melanocyte-Stimulating Hormones; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Inbred F344; Spironolactone; Vasopressins | 1984 |
19-Hydroxyandrostenedione: evidence for a new class of sodium-retaining and hypertensinogenic steroids.
Topics: Aldosterone; Androstenedione; Animals; Blood Pressure; Corticosterone; Desoxycorticosterone; Drug Interactions; Potassium; Rats; Renin; Sodium; Spironolactone | 1983 |
Hyperkalaemia in diabetes mellitus--potential hazards of coexisting hyporeninaemic hypoaldosteronism.
Topics: Adult; Aldosterone; Diabetes Mellitus, Type 1; Female; Humans; Hyperkalemia; Male; Middle Aged; Renin; Sepsis; Spironolactone; Staphylococcal Infections | 1984 |
[Study on renin-angiotensin-aldosterone system. I. Changes of plasma renin activity, plasma aldosterone concentration and urinary sodium excretion in normotensive subjects].
Topics: Adolescent; Adult; Aldosterone; Blood Pressure; Diet, Sodium-Restricted; Female; Humans; Male; Middle Aged; Renin; Sodium; Spironolactone | 1984 |
[Study on renin-angiotensin-aldosterone system. II. Changes of plasma renin activity, plasma aldosterone concentration and urinary sodium excretion in the hypertensives].
Topics: Adult; Aldosterone; Diet, Sodium-Restricted; Female; Humans; Hypertension; Male; Middle Aged; Renin; Sodium; Spironolactone | 1984 |
Metabolic effects of high dose amiloride and spironolactone: a comparative study in normal subjects.
Topics: Adult; Aldosterone; Amiloride; Angiotensin II; Dose-Response Relationship, Drug; Endocrine Glands; Humans; Male; Metabolism; Mineralocorticoids; Potassium; Pyrazines; Renin; Sodium; Spironolactone; Time Factors | 1984 |
Mineralocorticoid-specificity of aldosterone-induced protein synthesis in giant-toad (Bufo marinus) urinary bladders.
Topics: Aldosterone; Animals; Biological Transport; Bufo marinus; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; In Vitro Techniques; Protein Biosynthesis; Sodium; Spironolactone; Stimulation, Chemical; Urinary Bladder | 1983 |
Steroid-induced protein synthesis in giant-toad (Bufo marinus) urinary bladders. Correlation with natriferic activity.
Topics: Aldosterone; Animals; Biological Transport; Bufo marinus; Corticosterone; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Female; In Vitro Techniques; Protein Biosynthesis; Sodium; Spironolactone; Urinary Bladder | 1984 |
Diuretic treatment and renin-aldosterone axis in liver cirrhosis.
Topics: Aldosterone; Glomerular Filtration Rate; Humans; Liver Cirrhosis; Natriuresis; Renin-Angiotensin System; Spironolactone | 1984 |
Relation of rates of excretion of urinary prostaglandin E metabolites to administration of angiotensin, aldosterone, and spironolactone in vivo.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Animals; Hypertension; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Spironolactone | 1984 |
Inhibition of furosemide-induced kaliuresis in the rat by trilostane, an inhibitor of adrenal steroidogenesis.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Animals; Dihydrotestosterone; Diuresis; Furosemide; Male; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone | 1984 |
Mineralo- and glucocorticoid effects on renal excretion of electrolytes.
Topics: Adrenalectomy; Aldosterone; Animals; Creatinine; Desoxycorticosterone; Dexamethasone; Fludrocortisone; Glomerular Filtration Rate; Glucocorticoids; Kidney; Mineralocorticoids; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone; Sulfates | 1983 |
Bile secretion and liver microsomal enzyme modifications after chronic treatment with aldosterone, spironolactone, or furosemide.
Topics: Aldosterone; Animals; Bile; Cytochrome P-450 Enzyme System; Furosemide; Glycodeoxycholic Acid; Liver; Male; Microscopy, Electron; Microsomes, Liver; Rabbits; Sodium; Spironolactone | 1983 |
Recurrence of hypertension in primary aldosteronism after discontinuation of spironolactone. Time course of changes in cardiac output and body fluid volumes.
Topics: Aldosterone; Blood Pressure; Cardiac Output; Humans; Hyperaldosteronism; Hypertension; Potassium; Renin; Sodium; Spironolactone; Water-Electrolyte Balance | 1982 |
Characterization of a group of essential hypertensives with impaired regulation of aldosterone.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Angiotensin II; Female; Humans; Hypertension; Kinetics; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone | 1982 |
Plasma active and inactive renin and urinary kallikrein in normal subjects in response to hydrochlorothiazide, spironolactone or aldosterone administration.
Topics: Adult; Aldosterone; Blood Pressure; Enzyme Precursors; Female; Heart Rate; Humans; Hydrochlorothiazide; Kallikreins; Kinetics; Male; Renin; Sodium; Spironolactone | 1982 |
Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in toad bladder.
Topics: Aldosterone; Animals; Biological Transport, Active; Bufo marinus; Desoxycorticosterone; Kinetics; Sodium; Spironolactone; Urinary Bladder | 1981 |
The metabolism of aldosterone in kidney.
Topics: Adrenalectomy; Aldosterone; Animals; Cell Membrane; Cell Nucleus; Chromatography, High Pressure Liquid; Corticosterone; Kidney; Male; Progesterone; Rats; Rats, Inbred Strains; Spironolactone | 1983 |
Identification of mineralocorticoid target sites in the isolated rabbit cortical nephron.
Topics: Adrenalectomy; Aldosterone; Animals; Citrate (si)-Synthase; Female; Kinetics; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Mitochondria; Nephrons; Oxo-Acid-Lyases; Rabbits; Receptors, Drug; Spironolactone | 1980 |
[Role of tissue depots and the kaliuretic effect of aldosterone in potassium homeostasis].
Topics: Aldosterone; Animals; Desoxycorticosterone; Olivomycins; Potassium; Potassium Chloride; Puromycin; Rana temporaria; Rats; Spironolactone; Tissue Distribution; Water-Electrolyte Balance | 1981 |
The occurrence of hyperaldosteronism in infants with congestive heart failure.
Topics: Aldosterone; Body Weight; Epidemiologic Methods; Furosemide; Heart Failure; Humans; Hyperaldosteronism; Infant; Infant, Newborn; Male; Osmolar Concentration; Potassium; Renin; Sodium; Spironolactone | 1980 |
Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism.
Topics: Adult; Aldosterone; Child; Circadian Rhythm; Dexamethasone; Humans; Hydroxycorticosteroids; Hyperaldosteronism; Male; Potassium; Renin; Spironolactone | 1980 |
Hypertension in a four-year-old child: gas chromatographic and mass spectrometric evidence for deficient hepatic metabolism of steroids.
Topics: Aldosterone; Alkalosis; Child, Preschool; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Liver; Male; Renin; Spironolactone; Steroids; Triamterene | 1980 |
Inhibition of prostaglandins biosynthesis lowers antidiuretic hormone excretion in man.
Topics: Aldosterone; Blood; Diet, Sodium-Restricted; Humans; Indomethacin; Male; Osmolar Concentration; Prostaglandins E; Prostaglandins F; Renin; Spironolactone; Urine; Vasopressins | 1980 |
Evidence for a subgroup of essential hypertensives with non-suppressible excretion of aldosterone during sodium loading.
Topics: Aldosterone; Humans; Hypertension; Potassium; Renin; Sodium; Spironolactone | 1980 |
Influence of spironolactone on aldosterone metabolism in hyperaldosteronism.
Topics: Aldosterone; Corticosterone; Humans; Hyperaldosteronism; Kinetics; Progesterone; Renin; Spironolactone | 1980 |
Influence of unilateral adrenalectomy on renin-angiotensin-aldosterone system in primary aldosteronism.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Angiotensins; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Posture; Renin; Sodium; Spironolactone | 1980 |
Spironolactone bodies. An immunoperoxidase study with biochemical correlation.
Topics: Adrenal Glands; Aldosterone; Endoplasmic Reticulum; Histocytochemistry; Humans; Hydrocortisone; Immunoenzyme Techniques; Spironolactone | 1981 |
Bartter's syndrome: effect of indomethacin on prostaglandins, urinary kallikrein, renin-angiotensin-aldosterone system, and the response to angiotensin II antagonist.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adult; Aldosterone; Aminoglutethimide; Angiotensin II; Aspirin; Bartter Syndrome; Blood Pressure; Diet, Sodium-Restricted; Female; Humans; Hyperaldosteronism; Indomethacin; Kallikreins; Male; Middle Aged; Prostaglandins E; Renin; Spironolactone | 1980 |
Changes in urinary electrolytes versus serum electrolytes during treatment of primary hypertension with chlorthalidone alone and in combination with spironolactone.
Topics: Adult; Aldosterone; Chlorthalidone; Drug Therapy, Combination; Electrolytes; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone | 1981 |
Renal kallikrein excretion in alcoholic cirrhosis. Relationship to other vasoactive systems.
Topics: Adult; Aldosterone; Creatinine; Humans; Kallikreins; Kidney; Liver Cirrhosis, Alcoholic; Middle Aged; Potassium; Prostaglandin Antagonists; Prostaglandins E; Renin; Spironolactone | 1981 |
Renal kallikrein-kinin: its relation to renal prostaglandins and renin-angiotensin-aldosterone in man.
Topics: Adult; Aldosterone; Circadian Rhythm; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hypertension; Indomethacin; Kallikreins; Kidney; Kinins; Male; Middle Aged; Posture; Prostaglandins; Prostaglandins E; Prostaglandins F; Renin; Spironolactone | 1981 |
Primary aldosteronism -- screening, diagnosis and therapy.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Posture; Renin; Spironolactone | 1981 |
Bartter's syndrome.
Topics: Aldosterone; Bartter Syndrome; Brain Diseases, Metabolic; Child, Preschool; Electrolytes; Humans; Hyperaldosteronism; Infant; Male; Phenobarbital; Potassium; Renin; Spironolactone | 1981 |
Control of malignant ascites with spironolactone.
Topics: Abdominal Neoplasms; Aldosterone; Ascites; Breast Neoplasms; Female; Humans; Male; Renin; Sodium; Spironolactone | 1982 |
Plasma aldosterone levels in the female tortoise Testudo hermanni Gmelin in different experimental conditions.
Topics: Aldosterone; Animals; Corticosterone; Diet; Female; Furosemide; Potassium; Sodium; Spironolactone; Turtles | 1982 |
Acromegaly and hypertension: role of the renin-angiotensin-aldosterone system.
Topics: Acromegaly; Adult; Aged; Aldosterone; Blood Pressure; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Posture; Renin-Angiotensin System; Retrospective Studies; Spironolactone | 1982 |
[Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical studies].
Topics: Adult; Aldosterone; Animals; Canrenoic Acid; Female; Humans; Lymphocytes; Microscopy, Electron; Pregnadienes; Rats; Rats, Inbred Strains; Spironolactone | 1982 |
Comparative bioavailability of Verospiron and Aldactone tablets in humans.
Topics: Adult; Aldosterone; Biological Availability; Female; Humans; Male; Spironolactone; Tablets | 1982 |
[Physiopathology and therapy of the ascites in liver cirrhosis].
Topics: Aldosterone; Ascites; Diet, Sodium-Restricted; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Sodium; Spironolactone | 1982 |
Spironolactone bodies in aldosteronomas and in the attached adrenals. Enzyme histochemical study of 19 cases of primary aldosteronism and a case of aldosteronism due to bilateral diffuse hyperplasia of the zona glomerulosa.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Animals; Female; Histocytochemistry; Humans; Hyperaldosteronism; Hyperplasia; Interrenal Gland; Male; Middle Aged; Spironolactone | 1981 |
Modifications of bile secretion and liver microsomal enzymes by aldosterone and spironolactone.
Topics: Aldosterone; Animals; Bile; Bile Acids and Salts; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Erythrocytes; Liver; Male; Microsomes, Liver; Rabbits; Secretory Rate; Sodium; Spironolactone | 1980 |
Role of aldosterone in sodium retention of pregnancy in the rat.
Topics: Adrenal Glands; Aldosterone; Animals; Female; Kidney; Pregnancy; Pregnancy, Animal; Rats; Sodium; Spironolactone | 1981 |
Long term spironolactone and the adrenal cortex in essential hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adrenal Cortex; Adult; Aged; Aldosterone; Cosyntropin; Female; Humans; Hydrocortisone; Hypertension; Male; Middle Aged; Spironolactone | 1980 |
[Participation of aldosterone in pathogenesis of primary glaucoma (author's transl)].
Topics: Aldosterone; Glaucoma; Humans; Intraocular Pressure; Spironolactone | 1981 |
Hyperaldosteronism after heart surgery in children. Part I: Treatment with aldosterone antagonists.
Topics: Adolescent; Aldosterone; Canrenoic Acid; Child; Child, Preschool; Heart Defects, Congenital; Hematocrit; Humans; Hyperaldosteronism; Infant; Mineralocorticoid Receptor Antagonists; Postoperative Complications; Potassium; Sodium; Spironolactone | 1981 |
[Preoperative management of 461 hypertensive women].
Topics: Adult; Aged; Aldosterone; Blood Pressure; Diet, Sodium-Restricted; Female; Genital Diseases, Female; Humans; Hypertension; Middle Aged; Preoperative Care; Renin-Angiotensin System; Spironolactone | 1981 |
Spironolactone inhibits vascular reactivity by a prostaglandin related mechanism unconnected with aldosterone.
Topics: Aldosterone; Animals; Blood Pressure; Dose-Response Relationship, Drug; Indomethacin; Male; Norepinephrine; Ouabain; Potassium; Prostaglandins; Rats; Rats, Inbred Strains; Spironolactone; Splanchnic Circulation | 1981 |
Activity of sulfur-containing intermediate metabolites of spironolactone.
Topics: Adult; Aldosterone; Diuresis; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Structure-Activity Relationship | 1980 |
Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients.
Topics: Adult; Aldosterone; Amiloride; Angiotensin II; Bendroflumethiazide; Bicarbonates; Blood Pressure; Diuretics; Female; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Placebos; Potassium; Potassium Chloride; Pyrazines; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1980 |
[Adrenal aldosterone-producing adenoma: a diagnostic approach].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Angiography; Circadian Rhythm; Diagnosis, Differential; Female; Humans; Hyperplasia; Male; Middle Aged; Phlebography; Spironolactone | 1980 |
Induction of amiloride-sensitive sodium transport in the rat colon by mineralocorticoids.
Topics: Action Potentials; Aldosterone; Amiloride; Animals; Colon; Desoxycorticosterone; Drug Therapy, Combination; Furosemide; Male; Membrane Potentials; Rats; Sodium; Spironolactone | 1980 |
Toward more specific aldosterone antagonists. A radioreceptor assay approach.
Topics: Aldosterone; Animals; Dexamethasone; Dihydrotestosterone; Estradiol; Progesterone; Rats; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Spironolactone | 1980 |
Hyperaldosteronism associated with liver metastases.
Topics: Aldosterone; Alkaline Phosphatase; Ascites; Bilirubin; Edema; Female; Humans; Hyperaldosteronism; Liver Neoplasms; Male; Mineralocorticoid Receptor Antagonists; Serum Albumin; Spironolactone | 1980 |
The effect of the antimineralocorticoid, spironolactone on the hepatic synthesis of polar metabolites of aldosterone in male rats.
Topics: Aldosterone; Animals; Cytosol; Hydrogen-Ion Concentration; Kidney; Liver; Male; Organ Specificity; Rats; Spironolactone; Subcellular Fractions | 1980 |
Effect of aldosterone on ribonucleic acid polymerase activity in rat kidney cortical and medullary mitochondria.
Topics: Adrenalectomy; Aldosterone; Animals; DNA-Directed RNA Polymerases; Hydrocortisone; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Male; Mitochondria; Rats; Spironolactone | 1980 |
Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension.
Topics: Adenoma; Adult; Aldosterone; Blood Pressure; Female; Humans; Hyperaldosteronism; Hyperparathyroidism; Hypertension; Kidney Medulla; Medullary Sponge Kidney; Parathyroid Neoplasms; Spironolactone | 1980 |
[Hypotensive effect of spironolactone in patients with essential hypertension and aldosterone regulation disorders].
Topics: Adult; Aldosterone; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Spironolactone | 1980 |
Hormonal control of osmoregulation in the Chelonia. I. The effects of prolactin and interrenal steroids in freshwater chelonians.
Topics: Aldosterone; Animals; Corticosterone; Female; Glomerular Filtration Rate; Hypophysectomy; Magnesium; Male; Potassium; Prolactin; Sodium; Spironolactone; Turtles; Water-Electrolyte Balance | 1980 |
Use of piretanide, a new loop diuretic, in cirrhosis with ascites: relationship between the diuretic response and the plasma aldosterone level.
Topics: Adult; Aged; Aldosterone; Ascites; Diuretics; Drug Therapy, Combination; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Potassium; Spironolactone; Sulfonamides | 1980 |
Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Animals; Corticosterone; Dentate Gyrus; Electric Stimulation; Hippocampus; Hormone Antagonists; Long-Term Potentiation; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Spironolactone | 1995 |
Determinants of cardiac fibrosis in experimental hypermineralocorticoid states.
Topics: Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Drug Combinations; Fibrosis; Fludrocortisone; Heart; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Potassium; Rats; Rats, Sprague-Dawley; Spironolactone | 1995 |
Current-noise analysis of Na absorption in the embryonic coprodeum: stimulation by aldosterone and thyroxine.
Topics: Absorption; Aldosterone; Amiloride; Animals; Chick Embryo; Cloaca; Electric Conductivity; Electrophysiology; Epithelium; Intestinal Absorption; Ion Channel Gating; Ion Channels; Mathematics; Models, Biological; Ouabain; Sodium; Spironolactone; Thyroxine | 1993 |
Cardiovascular effects of microinjection of corticoids and antagonists into the rostral ventrolateral medulla in rats.
Topics: Aldosterone; Animals; Blood Pressure; Cardiovascular System; Corticosterone; Female; Glucocorticoids; Heart Rate; Male; Medulla Oblongata; Microinjections; Mifepristone; Mineralocorticoids; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spironolactone | 1995 |
Administration time-dependent change in the effect of spironolactone in rats.
Topics: Administration, Oral; Adrenalectomy; Aldosterone; Analysis of Variance; Animals; Circadian Rhythm; Desoxycorticosterone; Injections, Intraperitoneal; Male; Natriuresis; Potassium; Random Allocation; Rats; Rats, Wistar; Sodium; Specific Pathogen-Free Organisms; Spironolactone | 1994 |
Mineralocorticoid antagonist inhibits stress-induced blood pressure response after repeated daily warming.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Blood Pressure; Corticosterone; Heart Rate; Hot Temperature; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Spironolactone; Stress, Physiological | 1994 |
Hypertension and the mineralocorticoid receptor in the brain.
Topics: Adrenalectomy; Aldosterone; Amiloride; Animals; Blood Pressure; Brain; Cerebral Ventricles; Hippocampus; Hypertension; Infusions, Parenteral; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Mineralocorticoid; Spironolactone | 1994 |
Role of glucocorticoid in the development of glycyrrhizin-induced hypertension.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Blood Pressure; Corticosterone; Desoxycorticosterone; Dexamethasone; Glucocorticoids; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hydroxysteroid Dehydrogenases; Hypertension; Male; Mineralocorticoids; Potassium; Rats; Rats, Wistar; Renin; Spironolactone | 1994 |
Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist.
Topics: Aldosterone; Angioplasty, Balloon; Animals; Aorta; Blood Pressure; Coronary Disease; Iliac Artery; Rabbits; Random Allocation; Recurrence; Renin; Spironolactone; Tunica Intima | 1995 |
Aldosterone regulation in primary aldosteronism.
Topics: Adenoma; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Humans; Hyperaldosteronism; Spironolactone | 1994 |
Aldosterone response to adrenocorticotrophin and furosemide in primary aldosteronism after prolonged spironolactone treatment.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Female; Furosemide; Humans; Hyperaldosteronism; Male; Middle Aged; Posture; Renin; Spironolactone; Time Factors | 1994 |
Chronic administration of aldosterone depresses baroreceptor reflex function in the dog.
Topics: Aldosterone; Animals; Baroreflex; Blood Pressure; Catheters, Indwelling; Dogs; Female; Heart Rate; Infusions, Parenteral; Male; Nitroglycerin; Ouabain; Phenylephrine; Pressoreceptors; Reference Values; Regression Analysis; Spironolactone; Time Factors | 1994 |
Hypertension induced by a nonpressor dose of angiotensin II in kininogen-deficient rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Heart Rate; Hypertension; Kininogens; Kinins; Male; Molecular Weight; Rats; Sodium; Spironolactone | 1994 |
Opioid peptides, adrenocorticotrophic hormone, and idiopathic (orthostatic) edema.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; beta-Endorphin; Blood Urea Nitrogen; Body Weight; Dextroamphetamine; Dopamine; Edema; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Hypotension, Orthostatic; Middle Aged; Renin; Sodium; Spironolactone; Syndrome; Vasopressins | 1994 |
Unilateral adrenal hypersecretion of both aldosterone and cortisol in two first cousins with a syndrome of mineralocorticoid excess but without signs of hypercortisolism.
Topics: Adrenal Glands; Adult; Aldosterone; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hyperplasia; Hypertension; Male; Potassium; Renin; Spironolactone | 1994 |
Differential intracellular localization of human mineralocorticosteroid receptor on binding of agonists and antagonists.
Topics: Aldosterone; Animals; Cell Line; Cloning, Molecular; Humans; Immunohistochemistry; Ligands; Mice; Mice, Inbred BALB C; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Moths; Nucleopolyhedroviruses; Progesterone; Receptors, Mineralocorticoid; Spironolactone | 1994 |
Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome.
Topics: Adult; Aldosterone; Amiloride; Bartter Syndrome; Blood Gas Analysis; Blood Pressure; Creatinine; Drug Therapy, Combination; Female; Humans; Hydrogen-Ion Concentration; Hypokalemia; Kidney Diseases; Kidney Tubules; Magnesium; Magnesium Deficiency; Male; Metabolic Clearance Rate; Middle Aged; Potassium; Renin; Spironolactone; Syndrome | 1994 |
Immunochemical detection of the mineralocorticoid receptor in rat brain.
Topics: Adrenalectomy; Aldosterone; Animals; Blotting, Western; Brain Chemistry; Cell Aggregation; Cytosol; Electrophoresis, Polyacrylamide Gel; Immunoenzyme Techniques; Immunohistochemistry; Male; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone | 1993 |
Binding of spironolactone metabolites in vivo to renal mineralocorticoid receptors in guinea pigs.
Topics: Aldosterone; Animals; Binding, Competitive; Canrenone; Guinea Pigs; Kidney; Male; Receptors, Mineralocorticoid; Spironolactone | 1994 |
Aldosterone modulates glucocorticoid receptor binding in hippocampal cell cultures via the mineralocorticoid receptor.
Topics: Aldosterone; Androstanols; Animals; Binding, Competitive; Cells, Cultured; Dexamethasone; Down-Regulation; Hippocampus; Kinetics; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 1994 |
Dexamethasone enhances active cation transport in cultured aortic smooth muscle cells.
Topics: Aldosterone; Animals; Biological Transport, Active; Cations; Cell Membrane; Cells, Cultured; Dexamethasone; Membrane Potentials; Monensin; Muscle, Smooth, Vascular; Ouabain; Rats; Rats, Wistar; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Spironolactone; Stimulation, Chemical | 1994 |
Effects of low-sodium, high-potassium dietary intake on cochlear lateral wall Na+,K(+)-ATPase.
Topics: Aldosterone; Animals; Cochlea; Cochlear Duct; Diet, Sodium-Restricted; Enzyme-Linked Immunosorbent Assay; Male; Potassium; Potassium, Dietary; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Spironolactone; Stria Vascularis | 1994 |
Type II corticosteroid receptor stimulation increases NPY gene expression in basomedial hypothalamus of rats.
Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Glucose; Drug Interactions; Gene Expression Regulation; Hypothalamus, Middle; Infusions, Parenteral; Insulin; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Steroid; RNA, Messenger; Spironolactone | 1994 |
[The effect of aldosterone on the water-salt metabolism of the brown fatty tissue].
Topics: Adaptation, Physiological; Adipose Tissue, Brown; Aldosterone; Animals; Cold Temperature; Hot Temperature; Male; Rats; Rats, Wistar; Spironolactone; Water-Electrolyte Balance | 1993 |
[The prediction of blood pressure after adrenalectomy in primary aldosteronism].
Topics: Adrenalectomy; Adult; Aldosterone; Blood Pressure; Female; Furosemide; Humans; Hyperaldosteronism; Male; Middle Aged; Prognosis; Renin; Spironolactone | 1993 |
Fluid production by in vitro lungs from near-term fetal guinea pigs: effects of cortisol and aldosterone.
Topics: Aldosterone; Animals; Body Fluids; Gestational Age; Guinea Pigs; Hydrocortisone; Lung; Spironolactone | 1993 |
Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomyopathies; Fibrosis; Hyperaldosteronism; Hypertension; Hypertension, Renovascular; Male; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Spironolactone | 1993 |
Captopril and spironolactone therapy for refractory congestive heart failure.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Captopril; Drug Therapy, Combination; Female; Heart Failure; Humans; Kidney; Male; Middle Aged; Potassium; Sodium; Spironolactone | 1993 |
Independence of salt intake induced by calcium deprivation from the renin-angiotensin-aldosterone system.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Calcium; Diet; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin; Sodium; Sodium Chloride; Sodium, Dietary; Spironolactone | 1993 |
Plasma volume contraction in portal hypertension.
Topics: Aged; Aldosterone; Blood Pressure; Dose-Response Relationship, Drug; Female; Furosemide; Hemodynamics; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Middle Aged; Plasma Volume; Regional Blood Flow; Spironolactone; Time Factors | 1993 |
K infusion corrects thick ascending limb Cl reabsorption in K-depleted rats by an aldosterone-independent mechanism.
Topics: Absorption; Aldosterone; Animals; Chlorides; Infusions, Intravenous; Loop of Henle; Male; Potassium; Potassium Deficiency; Rats; Rats, Sprague-Dawley; Reference Values; Spironolactone | 1993 |
Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes.
Topics: 3T3 Cells; Adipose Tissue; Aldosterone; Androstanols; Animals; Binding, Competitive; Cell Differentiation; Glycerolphosphate Dehydrogenase; Hydrocortisone; Mice; Receptors, Glucocorticoid; Spironolactone; Triglycerides | 1993 |
Alterations of calcium metabolism and of parathyroid function in primary aldosteronism, and their reversal by spironolactone or by surgical removal of aldosterone-producing adenomas.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Aged; Aldosterone; Analysis of Variance; Blood Pressure; Body Mass Index; Calcium; Creatinine; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Parathyroid Glands; Parathyroid Hormone; Spironolactone | 1995 |
Differential regulation of Na+-K+-ATPase gene expression by corticosteriods in vascular smooth muscle cells.
Topics: Adrenal Cortex Hormones; Aldosterone; Amiloride; Analysis of Variance; Animals; Aorta, Thoracic; Cells, Cultured; Dexamethasone; Gene Expression Regulation, Enzymologic; Kinetics; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1996 |
Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor.
Topics: Aldosterone; Cell-Free System; Cysteine; Humans; Kinetics; Methyl Methanesulfonate; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Protein Binding; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Sulfhydryl Reagents | 1996 |
The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not.
Topics: 2-Amino-5-phosphonovalerate; Aldosterone; Aminoglutethimide; Animals; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mineralocorticoid Receptor Antagonists; Spironolactone | 1996 |
Role of aldosterone in the remnant kidney model in the rat.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Spironolactone; Tetrazoles | 1996 |
Effects of aldosterone and spironolactone on the isolated perfused rat heart.
Topics: Aldosterone; Analysis of Variance; Animals; Cardiac Output; Coronary Circulation; Dose-Response Relationship, Drug; Drug Interactions; Heart; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Perfusion; Rats; Rats, Sprague-Dawley; Spironolactone | 1996 |
Effects of corticosteroids on parameters related to Na+ transport by amphibian renal distal cells (A6) in culture.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biological Transport; Cell Line; Corticosterone; Dexamethasone; Electrophysiology; Epithelium; Glucocorticoids; Hormone Antagonists; Kidney Tubules, Distal; Mifepristone; Mineralocorticoid Receptor Antagonists; Ouabain; Receptors, Glucocorticoid; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Xenopus laevis | 1996 |
Role of de novo protein synthesis and calmodulin in rapid activation of Na(+)-H+ exchange of aldosterone in frog diluting segment.
Topics: Aldosterone; Animals; Biotransformation; Calmodulin; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Distal; Male; Mineralocorticoid Receptor Antagonists; Protein Biosynthesis; Protein Synthesis Inhibitors; Rana temporaria; Receptors, Mineralocorticoid; Sodium-Hydrogen Exchangers; Spironolactone | 1996 |
Characterization of adrenal hormone binding sites in the prairie vole.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Androstanols; Animals; Arginine Vasopressin; Arvicolinae; Binding Sites; Brain; Cytosol; Dexamethasone; Hypertrophy; Kinetics; Mineralocorticoids; Rats; Receptors, Glucocorticoid; Spironolactone; Thymus Gland | 1997 |
Adrenal independence of fluid and electrolyte reabsorption in the ductuli efferentes testis of the rat.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Body Fluids; Ejaculatory Ducts; Electrolytes; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Osmolar Concentration; Rats; Rats, Wistar; Spironolactone; Testis | 1997 |
Mineralocorticoid (type I) receptors in the olfactory mucosa of the mammal: studies with [3H]aldosterone and the anti-mineralocorticoid spironolactone.
Topics: Aldosterone; Animals; Binding, Competitive; Carbon Radioisotopes; Dose-Response Relationship, Drug; Guinea Pigs; Isotope Labeling; Male; Mineralocorticoid Receptor Antagonists; Olfactory Mucosa; Receptors, Mineralocorticoid; Spironolactone; Tritium | 1997 |
Cell-specific, promoter-dependent mineralocorticoid agonist activity of spironolactone.
Topics: Aldosterone; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Humans; Mifepristone; Promoter Regions, Genetic; Spironolactone; Tumor Cells, Cultured | 1997 |
Aldosterone rapidly represses protein kinase C activity in neonatal rat cardiomyocytes in vitro.
Topics: Aldosterone; Analysis of Variance; Animals; Animals, Newborn; Calcium; Cells, Cultured; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Fibroblasts; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spironolactone; Tetradecanoylphorbol Acetate; Tritium | 1997 |
[Implication of type II glucocorticoid receptors in aldosterone induced apoptosis of rat thymocytes].
Topics: Aldosterone; Animals; Apoptosis; Dexamethasone; Glucocorticoids; Rats; Rats, Wistar; Receptors, Glucocorticoid; Spironolactone; Thymus Gland | 1997 |
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
Topics: Aldosterone; Animals; Anti-Bacterial Agents; Cell Line; Dogs; Enzyme Inhibitors; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Macrolides; Meglumine; Membrane Potentials; Naphthalenes; Pertussis Toxin; Protein Kinase C; Protein Serine-Threonine Kinases; Proton Pump Inhibitors; Proton-Translocating ATPases; Sodium-Hydrogen Exchangers; Spironolactone; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zinc | 1997 |
21-Hydroxy-6,19-oxidoprogesterone: a novel synthetic steroid with specific antiglucocorticoid properties in the rat.
Topics: Aldosterone; Androstanols; Animals; Kidney; Male; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Structure-Activity Relationship; Thymus Gland; Transcortin; Tritium | 1997 |
Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists.
Topics: Aldosterone; Animals; Biological Transport; Cell Compartmentation; Cells, Cultured; Genes, Reporter; Green Fluorescent Proteins; Luminescent Proteins; Mineralocorticoid Receptor Antagonists; Nuclear Matrix; Protein Binding; Receptors, Mineralocorticoid; Recombinant Fusion Proteins; Spironolactone; Transcription, Genetic | 1998 |
Mineralocorticoid receptor-mediated enhancement of neuronal excitability and synaptic plasticity in the dentate gyrus in vivo is dependent on the beta-adrenergic activity.
Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aldosterone; Animals; Dentate Gyrus; Dibenzylchlorethamine; Epinephrine; Evoked Potentials; Male; Mineralocorticoid Receptor Antagonists; Neuronal Plasticity; Neurons; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Mineralocorticoid; Spironolactone; Stimulation, Chemical | 1998 |
Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.
Topics: Aldosterone; Animals; Apoptosis; Corticosterone; Glucocorticoids; Hormone Antagonists; Lymphocyte Activation; Lymphocytes; Metamorphosis, Biological; Mifepristone; Spironolactone; Spleen; Thymus Gland; Xenopus laevis | 1997 |
Localization of Na,K-ATPase activity in developing rat distal colon: role of corticosteroids.
Topics: 4-Nitrophenylphosphatase; Adrenal Cortex Hormones; Adrenalectomy; Aging; Aldosterone; Animals; Colon; Desoxycorticosterone; Dexamethasone; Glucocorticoids; Hormone Antagonists; Intestinal Mucosa; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Ouabain; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sodium-Potassium-Exchanging ATPase; Spironolactone | 1998 |
[Hypertension treatable with glucocorticoids: report of a case].
Topics: Aldosterone; Dexamethasone; Female; Glucocorticoids; Humans; Hypertension; Middle Aged; Potassium; Sodium; Spironolactone | 1997 |
Inhibition of tissue repair by spironolactone: role of mineralocorticoids in fibrous tissue formation.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Animals; Diet; Gene Expression; Granulation Tissue; Hydroxyproline; Hydroxysteroid Dehydrogenases; Male; Mineralocorticoids; Models, Biological; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone; Wound Healing | 1998 |
Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids.
Topics: Aldosterone; Androstanols; Animals; Biological Transport; Colon; Drug Combinations; Electric Conductivity; Glucocorticoids; Male; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Rats; Rats, Wistar; Sodium; Spironolactone | 1999 |
Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aldosterone; Animals; Calcium Signaling; Coronary Vessels; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Estradiol; Gene Expression Regulation; Hydrocortisone; Isoproterenol; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Spironolactone; Swine; Sympathomimetics; Transcription, Genetic | 1999 |
Aldosterone directly induces Na, K-ATPase alpha 1-subunit mRNA in the renal cortex of rat.
Topics: Aldosterone; Amiloride; Animals; Blood Pressure; Gene Expression Regulation, Enzymologic; Hypertension; Kidney; Rats; Rats, Inbred Strains; RNA, Messenger; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Spironolactone; Time Factors | 1999 |
Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts.
Topics: Aldosterone; Amiloride; Animals; Arachidonic Acid; Bicarbonates; Colon; Diuretics; Extracellular Space; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Ion Exchange; Ion Transport; Leukotriene Antagonists; Male; Mineralocorticoid Receptor Antagonists; Phospholipases; Prostaglandin Antagonists; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers; Spironolactone; Transcription, Genetic | 1999 |
Medical management of aldosterone-producing adenomas.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Retrospective Studies; Spironolactone | 1999 |
Aldosterone and spironolactone in heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Drug Therapy, Combination; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1999 |
Aldosterone antagonism in heart failure.
Topics: Adrenergic beta-Antagonists; Aldosterone; Algorithms; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone | 1999 |
Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms.
Topics: Aldosterone; Animals; Aorta, Thoracic; Cells, Cultured; Cycloheximide; Cytoskeleton; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Hormone Antagonists; Hydrogen-Ion Concentration; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sodium-Hydrogen Exchangers; Spironolactone; Transcription, Genetic | 1999 |
Effects of glucocorticoids and mineralocorticoids on proliferation and maturation of human peripheral blood stem cells.
Topics: Adult; Aldosterone; Cells, Cultured; Colony-Forming Units Assay; Desoxycorticosterone; Erythropoietin; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Interleukin-3; Mifepristone; Mineralocorticoids; Recombinant Proteins; Spironolactone; Triamcinolone Acetonide | 1999 |
Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats.
Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Captopril; Cerebral Hemorrhage; Dexamethasone; Drug Interactions; Hydralazine; Hypertension; Male; Rats; Rats, Inbred SHR; Spironolactone; Stroke; Survival Rate; Time Factors | 1999 |
[Factors for postoperative persistent hypertension in patients with aldosterone-producing adenoma].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Age Factors; Aldosterone; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension, Renal; Male; Middle Aged; Postoperative Period; Spironolactone | 1997 |
Medical management of aldosterone-producing adenomas.
Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2000 |
The amygdala: site of genomic and nongenomic arousal of aldosterone-induced sodium intake.
Topics: Aldosterone; Amygdala; Animals; Appetite; Arousal; Corticosterone; Desoxycorticosterone; Genome; Hormone Antagonists; Injections; Injections, Intraventricular; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2000 |
Nongenomic effects of aldosterone on Ca2+ in M-1 cortical collecting duct cells.
Topics: Aldosterone; Animals; Biological Transport; Calcium; Cell Line; Dactinomycin; Enzyme Inhibitors; Genome; Intracellular Membranes; Kidney Cortex; Kidney Tubules, Collecting; Mice; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Nucleic Acid Synthesis Inhibitors; Osmolar Concentration; Ouabain; Protein Kinase C; Sodium; Spironolactone | 2000 |
Micromolar concentrations of steroids and of aldosterone antagonists inhibit the outwardly rectifying chloride channel with different kinetics.
Topics: Aldosterone; Anti-Inflammatory Agents; Canrenone; Chloride Channels; Corticosterone; Cytosol; Dose-Response Relationship, Drug; Estradiol; HT29 Cells; Humans; Hydrocortisone; Ion Channel Gating; Kinetics; Lipids; Mineralocorticoid Receptor Antagonists; Patch-Clamp Techniques; Progesterone; Spironolactone; Testosterone | 2000 |
Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hypertension; Insulin; Insulin Resistance; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Spironolactone | 2000 |
Paradoxical effects of mineralocorticoids on the ion gated sodium channel in embryologically diverse cells.
Topics: Aldosterone; Animals; Cattle; Cell Division; Cells, Cultured; Cornea; Embryo, Mammalian; Epithelial Sodium Channels; Fibroblasts; Humans; Ion Channel Gating; Leukemia, Erythroblastic, Acute; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Pigment Epithelium of Eye; Receptors, Mineralocorticoid; Sodium Channels; Spironolactone; Tumor Cells, Cultured | 2000 |
Effects of spironolactone on systolic blood pressure in experimental diabetic rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Animals; Corticosterone; Diabetes Mellitus, Experimental; Hydroxysteroid Dehydrogenases; Male; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Streptozocin; Systole | 2000 |
[Decrease in mortality on spironolactone being added to the conventional treatment of heart failure].
Topics: Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Follow-Up Studies; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Time Factors | 2000 |
Aldosterone mediates angiotensin II-stimulated rat vascular smooth muscle cell proliferation.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Cell Division; Cells, Cultured; Cytochrome P-450 CYP11B2; Drug Synergism; Losartan; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Stimulation, Chemical | 2000 |
Bilateral adrenal cortical hyperplasia.
Topics: Adult; Aldosterone; Diagnosis, Differential; Diuretics; Female; Humans; Hydrocortisone; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 2000 |
Different regulation of cardiac and renal corticosteroid receptors in aldosterone-salt treated rats: effect of hypertension and glucocorticoids.
Topics: Adrenalectomy; Age Factors; Aldosterone; Angiotensin II; Animals; Atrial Natriuretic Factor; Blotting, Western; Collagen; Glucocorticoids; Heart; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Steroid; RNA, Complementary; Sodium Chloride; Spironolactone; Time Factors | 2000 |
Mechanism of action of the potent sodium-retaining steroid 11, 19-oxidoprogesterone.
Topics: Aldosterone; Animals; Antifungal Agents; Binding, Competitive; Biological Transport; Cell Nucleus; Drug Antagonism; HSP90 Heat-Shock Proteins; Kidney; Lysine; Male; Metabolic Clearance Rate; Mineralocorticoid Receptor Antagonists; Molecular Conformation; Progesterone; Pyrans; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Receptors, Steroid; Sodium; Spiro Compounds; Spironolactone | 2000 |
The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes.
Topics: Adipose Tissue, Brown; Aldosterone; Animals; Carrier Proteins; Cell Differentiation; Dose-Response Relationship, Drug; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Hormone Antagonists; Lipoma; Lipoprotein Lipase; Mice; Mifepristone; Mineralocorticoid Receptor Antagonists; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Transcription Factors; Transcription, Genetic; Triglycerides; Tumor Cells, Cultured | 2000 |
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blotting, Northern; Creatinine; Disease Progression; Fibrosis; Gene Expression; Glomerulosclerosis, Focal Segmental; In Situ Hybridization; Kidney Glomerulus; Male; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2000 |
Epidemiology and pathophysiology of heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Disease Progression; Heart Failure; Humans; Incidence; Pulse; Ramipril; Spironolactone; Survival Analysis; Ventricular Function, Left | 2000 |
Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure.
Topics: Adolescent; Adult; Aged; Aldosterone; Aorta; Coronary Vessels; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardium; Peptide Fragments; Procollagen; Reference Values; Spironolactone; Stroke Volume; Ventricular Function, Left | 2000 |
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibitors; Eplerenone; Hormone Antagonists; Kidney; Male; Myocardium; Necrosis; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Renal Artery; Renin; Sodium Chloride; Spironolactone; Vascular Diseases | 2000 |
Cardiac aldosterone production in genetically hypertensive rats.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Corticosterone; Cytochrome P-450 CYP11B2; Heart Ventricles; Hypertension; In Vitro Techniques; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; RNA, Messenger; Spironolactone | 2000 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic Disease; Electrolytes; Female; Humans; Hydrocortisone; Losartan; Male; Nitrogen; Spironolactone | 2000 |
Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton.
Topics: Actins; Aldosterone; Cell Line; Cytochalasin D; Cytoskeleton; Endothelium, Vascular; Epithelial Sodium Channels; Ethanol; Humans; Immunohistochemistry; Microscopy, Confocal; Receptors, Mineralocorticoid; RNA, Messenger; Signal Transduction; Sodium Channels; Spironolactone; Tubulin | 2001 |
Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats.
Topics: Age Factors; Aldosterone; Animals; Aorta; Carotid Arteries; Endomyocardial Fibrosis; Fibrosis; Hemodynamics; Rats; Rats, Sprague-Dawley; Spironolactone; Vascular Resistance | 2001 |
Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Blood Pressure; Body Weight; Cardiovascular Diseases; Fibroblast Growth Factor 2; Heart; Immunohistochemistry; Mineralocorticoid Receptor Antagonists; NF-kappa B; Organ Size; Platelet-Derived Growth Factor; Rats; Receptors, Mineralocorticoid; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Tetrazoles; Transcription Factor AP-1; Transforming Growth Factor beta; Valine; Valsartan | 2001 |
[Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5].
Topics: Aldosterone; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Lung; Male; Mineralocorticoid Receptor Antagonists; Pulmonary Fibrosis; Rats; Rats, Wistar; Spironolactone | 1998 |
[Biological factors influencing response to diuretics in patients with cirrhosis and ascites].
Topics: Aldosterone; Ascites; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyperkalemia; Hyponatremia; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Norepinephrine; Renin; Renin-Angiotensin System; Spironolactone; Sympathetic Nervous System; Treatment Outcome | 2001 |
Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone.
Topics: Aldosterone; Animals; Carrier Proteins; Diuretics; Drug Synergism; Furosemide; Male; Metabolism; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sodium Chloride Symporters; Solute Carrier Family 12, Member 3; Spironolactone; Symporters | 2001 |
Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Calibration; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Heart Ventricles; Lung; Mineralocorticoid Receptor Antagonists; Myocardium; Peptidyl-Dipeptidase A; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Up-Regulation | 2001 |
Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries.
Topics: Aldosterone; Angioplasty, Balloon; Animals; Collagen; Constriction, Pathologic; Coronary Disease; Coronary Vessels; Elastin; Eplerenone; Iliac Artery; Male; Mineralocorticoid Receptor Antagonists; Spironolactone; Swine; Swine, Miniature; Tunica Intima | 2001 |
A family with liddle's syndrome caused by a mutation in the beta subunit of the epithelial sodium channel.
Topics: Aldosterone; Alkalosis; Base Sequence; Blood Gas Analysis; Calcium Channel Blockers; Diagnosis, Differential; Diuretics; DNA Mutational Analysis; Epithelium; Family Health; Female; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Molecular Sequence Data; Mutagenesis; Point Mutation; Potassium; Renin; Sodium Channels; Spironolactone; Syndrome; Triamterene | 2001 |
New treasures from old? EPHESUS. Eplerenome Post-AHI Heart Failure Efficacy and Survival Study.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Renin-Angiotensin System; Spironolactone | 2001 |
The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival Study.
Topics: Aldosterone; Double-Blind Method; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Multicenter Studies as Topic; Myocardial Infarction; Randomized Controlled Trials as Topic; Research Design; Sample Size; Spironolactone; Survival Analysis; Systole | 2001 |
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
Topics: Aldosterone; Animals; Aorta; Basal Ganglia; Blood Pressure; Body Weight; Cerebral Cortex; Cerebral Infarction; Epidermal Growth Factor; ErbB Receptors; Genetic Predisposition to Disease; In Vitro Techniques; Infarction, Middle Cerebral Artery; Male; Mineralocorticoid Receptor Antagonists; Ophthalmic Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Spironolactone; Stroke | 2001 |
Trans-tubular potassium gradient in patients with drug-induced hyperkalemia.
Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Captopril; Creatinine; Female; Humans; Hyperkalemia; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Potassium; Renal Insufficiency; Spironolactone; Uremia | 2001 |
Nongenomic regulation of ENaC by aldosterone.
Topics: Aldosterone; Amiloride; Animals; Cyclic AMP; Diuretics; Dogs; Enzyme Inhibitors; Epithelial Cells; Epithelial Sodium Channels; Humans; Ion Channel Gating; Kidney Tubules, Collecting; Lymphocytes; Mice; Patch-Clamp Techniques; Rabbits; Rats; Rats, Sprague-Dawley; Renal Agents; Sodium; Sodium Channels; Spironolactone; Thionucleotides; Vasopressins | 2001 |
Aldosterone 2001.
Topics: Aldosterone; Alternative Splicing; Body Composition; Calcium Channels; Epithelial Sodium Channels; Eplerenone; Glycyrrhiza; Humans; Phosphatidylinositol 3-Kinases; Plasminogen Activator Inhibitor 1; Receptors, Cytoplasmic and Nuclear; Receptors, Mineralocorticoid; Sodium Channels; Spironolactone; Transcription Factors; Vasopressins | 2001 |
Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Capsaicin; Denervation; Female; Hypertension; Mineralocorticoid Receptor Antagonists; Neurons, Afferent; Pregnancy; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Sodium, Dietary; Spironolactone | 2001 |
Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.
Topics: Adenylyl Cyclases; Aldosterone; Bronchi; Calcium; Cell Line, Transformed; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Inhibitors; Epithelial Cells; Glucocorticoids; GTP-Binding Proteins; Humans; Intracellular Membranes; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Protein Synthesis Inhibitors; Sodium; Spironolactone; Thapsigargin; Time Factors; Uridine Triphosphate; Vanadates | 2001 |
Insulin and mineralocorticoids influence on extrarenal potassium metabolism in chronic hemodialysis patients.
Topics: Aged; Aged, 80 and over; Aldosterone; Female; Fludrocortisone; Glucose; Humans; Insulin; Insulin Secretion; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoids; Potassium; Renal Dialysis; Spironolactone | 2001 |
Normokalemic hyperaldosteronism in patients with resistant hypertension.
Topics: Adult; Aged; Aldosterone; Analysis of Variance; Antihypertensive Agents; Creatinine; Female; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Retrospective Studies; Sensitivity and Specificity; Spironolactone | 2002 |
Primary aldosteronism: the most frequent form of secondary hypertension?
Topics: Aldosterone; Antihypertensive Agents; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Mineralocorticoid Receptor Antagonists; Potassium; Renin; Spironolactone | 2002 |
The endothelin-aldosterone axis and cardiovascular diseases.
Topics: Adrenal Cortex; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Clinical Trials as Topic; Collagen; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Morbidity; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Receptor, Endothelin B; Renin-Angiotensin System; Spironolactone | 2001 |
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Inclusion Bodies; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Nifedipine; Spironolactone; Tomography, X-Ray Computed; Vasodilator Agents; Zona Glomerulosa | 2001 |
Cardiac damage prevention by eplerenone: comparison with low sodium diet or potassium loading.
Topics: Aldosterone; Angiotensin II; Animals; Diet, Sodium-Restricted; Disease Models, Animal; Eplerenone; Heart Diseases; Male; Mineralocorticoid Receptor Antagonists; NG-Nitroarginine Methyl Ester; Potassium; Rats; Rats, Wistar; Spironolactone | 2002 |
Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice.
Topics: Aldosterone; Animals; Audiometry, Pure-Tone; Auditory Threshold; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Loss, Sensorineural; Male; Mice; Mice, Inbred Strains; Prednisolone; Probability; Random Allocation; Reference Values; Sensitivity and Specificity; Spironolactone | 2002 |
Aldosterone signaling pathway across the nuclear envelope.
Topics: Aldosterone; Animals; Electrophysiology; Female; Microscopy, Atomic Force; Mineralocorticoid Receptor Antagonists; Nuclear Envelope; Oocytes; Signal Transduction; Spironolactone; Xenopus laevis | 2002 |
The role of spironolactone in the treatment of patients with refractory hypertension.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Renin; Spironolactone | 2002 |
Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells.
Topics: Adrenomedullin; Aldosterone; Aorta; Cells, Cultured; Gene Expression; Humans; Muscle, Smooth, Vascular; Peptide Fragments; Peptides; Protein Precursors; Proteins; Spironolactone | 2002 |
[Aldosterone blockade in heart failure. So much for so little].
Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Clinical Trials as Topic; Coronary Circulation; Diuretics; Heart Failure; Hemodynamics; Humans; Microcirculation; Mineralocorticoid Receptor Antagonists; Placebos; Rats; Rats, Inbred WKY; Spironolactone | 2002 |
Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Corticosterone; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypertension; Imidazoles; Male; Natriuretic Peptide, Brain; Prodrugs; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Spironolactone; Stroke; Tetrazoles; Time Factors | 2002 |
Interconversion pharmacokinetics of eplerenone, a selective aldosterone blocker, and its lactone-ring open form.
Topics: Aldosterone; Animals; Dogs; Eplerenone; Female; Injections, Intravenous; Lactones; Models, Animal; Spironolactone | 2002 |
Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor.
Topics: Aldosterone; Biological Transport; Dose-Response Relationship, Drug; Down-Regulation; Glucose; Humans; Insulin; Kinetics; Protein Binding; Receptor, Insulin; Receptors, Mineralocorticoid; RNA; RNA, Messenger; Spironolactone; Thymidine; Time Factors; U937 Cells | 2002 |
Mineralocorticoid and angiotensin receptor antagonism during hyperaldosteronemia.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Eplerenone; Heart Ventricles; Hyperaldosteronism; Losartan; Magnesium; Male; Membrane Potentials; Mineralocorticoid Receptor Antagonists; Patch-Clamp Techniques; Potassium; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Ventricular Function | 2002 |
Rapid effects of aldosterone and spironolactone in the isolated working rat heart.
Topics: Aldosterone; Animals; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Myocardial Contraction; Perfusion; Rats; Rats, Inbred WKY; Spironolactone | 2002 |
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
Topics: Aldosterone; Analysis of Variance; Animals; Dansyl Compounds; DNA; Electrophoretic Mobility Shift Assay; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Kidney; Macrophages; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Transcription Factor AP-1 | 2002 |
Spironolactone increases integrin beta3 gene expression in kidney and heart muscle cells.
Topics: Aldosterone; Animals; Animals, Newborn; Binding, Competitive; Cell Line; Dexamethasone; Gene Expression Profiling; Gene Expression Regulation; Integrin beta3; Kidney; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Rats; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Xenopus | 2002 |
Spironolactone improves angiotensin-induced vascular changes and oxidative stress.
Topics: Aldosterone; Angiotensin II; Animals; Arteries; Blood Pressure; Culture Techniques; Endothelium, Vascular; Heart; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renin; Spironolactone; Superoxides; Thiobarbituric Acid Reactive Substances; Vascular Resistance | 2002 |
Sodium transporter abundance profiling in kidney: effect of spironolactone.
Topics: Adrenalectomy; Aldosterone; Animals; Diet, Sodium-Restricted; Epithelial Sodium Channels; Immunoenzyme Techniques; Kidney Tubules, Collecting; Kidney Tubules, Distal; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Sodium Chloride Symporters; Sodium Chloride, Dietary; Spironolactone; Symporters | 2002 |
New treatments for myocardial fibrosis.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Canrenone; Clinical Trials as Topic; Endomyocardial Fibrosis; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Rats; Spironolactone | 2002 |
Aldosterone induces a vascular inflammatory phenotype in the rat heart.
Topics: Aldosterone; Animals; Blood Pressure; Chemokine CCL2; Coronary Vessels; Cyclooxygenase 2; Endomyocardial Fibrosis; Eplerenone; Gene Expression; Hypertension; Immunohistochemistry; In Situ Hybridization; Intercellular Adhesion Molecule-1; Isoenzymes; Male; Myocardium; Osteopontin; Phenotype; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Spironolactone; Vascular Cell Adhesion Molecule-1; Vasculitis | 2002 |
Aldosterone-induced inflammation in the rat heart : role of oxidative stress.
Topics: Aldosterone; Animals; Antioxidants; Cardiomyopathies; Cell Division; Cell Movement; Fibrosis; Heart; Immunologic Factors; Inflammation; Lymphocytes; Macrophages; Male; Mineralocorticoid Receptor Antagonists; Monocytes; Myocardium; NADPH Oxidases; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Tyrosine | 2002 |
[Selective aldosterone blocker for hypertension and heart failure. Better tolerance than previous drugs].
Topics: Aldosterone; Clinical Trials as Topic; Eplerenone; Heart Failure; Humans; Hypertension; Spironolactone | 2002 |
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels; Corticosterone; Cyclooxygenase 2; Diuresis; Drinking; Eating; Eplerenone; Heart; Hypertension; Isoenzymes; Macrophages; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Necrosis; Organ Size; Osteopontin; Potassium; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Renin; Sialoglycoproteins; Sodium; Sodium Chloride; Spironolactone; Vasculitis | 2002 |
Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone.
Topics: Aldosterone; Animals; Blood Pressure; Blotting, Northern; Carotid Arteries; Collagen; Collagen Type I; Collagen Type III; Disease Models, Animal; Dose-Response Relationship, Drug; Elasticity; Elastin; Eplerenone; Fibronectins; Hyperaldosteronism; Immunohistochemistry; Injections, Subcutaneous; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Spironolactone; Ultrasonography; Vascular Patency | 2002 |
Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity.
Topics: Aldosterone; Animals; Chronic Disease; Collagen Type I; Collagen Type IV; Cyclosporine; Fibronectins; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; RNA, Messenger; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats.
Topics: Aldosterone; Animals; Coronary Vessels; Heart Failure; Ligation; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone; Tumor Necrosis Factor-alpha; Ventricular Function, Left | 2003 |
Route of steroid-activated macromolecules through nuclear pores imaged with atomic force microscopy.
Topics: Aldosterone; Animals; Calcium; Cell Nucleus; Chelating Agents; Dactinomycin; Electrophysiology; Microscopy, Atomic Force; Mineralocorticoid Receptor Antagonists; Models, Biological; Nuclear Pore; Nucleic Acid Synthesis Inhibitors; Receptors, Mineralocorticoid; Ribonuclease, Pancreatic; Spironolactone; Steroids; Time Factors; Xenopus | 2003 |
Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels.
Topics: Aldosterone; Animals; Canrenoic Acid; Cation Transport Proteins; CHO Cells; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electric Stimulation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Spironolactone; Trans-Activators; Transcriptional Regulator ERG; Transfection | 2003 |
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels.
Topics: Aldosterone; Animals; Aorta, Thoracic; Catalytic Domain; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Eplerenone; Indoles; Ionophores; Male; Maleimides; Mineralocorticoid Receptor Antagonists; Monensin; Protein Biosynthesis; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Transcription, Genetic | 2003 |
Interdomain interactions in the mineralocorticoid receptor.
Topics: Aldosterone; Animals; COS Cells; Dimerization; Humans; Hydrocortisone; Point Mutation; Protein Structure, Tertiary; Receptors, Mineralocorticoid; Recombinant Fusion Proteins; Spironolactone; Transcriptional Activation; Two-Hybrid System Techniques | 2003 |
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.
Topics: Aldosterone; Blotting, Northern; Cell Line; Ciliary Body; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Epithelial Sodium Channels; Gene Expression Regulation; Glucocorticoids; Hormone Antagonists; Humans; Immediate-Early Proteins; In Situ Hybridization; Isoenzymes; Mifepristone; Mineralocorticoid Receptor Antagonists; Nuclear Proteins; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channels; Spironolactone | 2003 |
[Conn syndrome as cause of stubborn hypertension. Which hypertensives should you screen?].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic beta-Antagonists; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diagnosis, Differential; Diuretics; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; Renin; Sensitivity and Specificity; Spironolactone; Tomography, X-Ray Computed | 2003 |
Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle.
Topics: Adrenalectomy; Aldosterone; Animals; Aorta; Bumetanide; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Spironolactone; Time Factors; Vasoconstrictor Agents | 2003 |
Aldosterone blockade and heart failure.
Topics: Aldosterone; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Spironolactone; Ventricular Dysfunction, Left | 2003 |
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats.
Topics: Aldosterone; Animals; Blood Pressure; Cytokines; Eplerenone; Fibrosis; Hypertension, Renal; Immunohistochemistry; In Situ Hybridization; Kidney; Macrophages; Male; Nephritis; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone | 2003 |
Hypertension, angiotensin II, aldosterone, and race.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Antihypertensive Agents; Black People; Eplerenone; Humans; Hypertension; Losartan; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone; Treatment Outcome; White People | 2003 |
Transcardiac gradient of aldosterone before and after spironolactone in patients with congestive heart failure.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Female; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Patients; Spironolactone | 2003 |
Aldosterone inhibits inducible nitric oxide synthase in neonatal rat cardiomyocytes.
Topics: Aldosterone; Animals; Animals, Newborn; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucocorticoids; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Aldosterone antagonism and hypertension.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Physiological Phenomena; Cardiovascular System; Drug Therapy, Combination; Eplerenone; Humans; Hypertension; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Spironolactone; Treatment Outcome | 2003 |
Combined effects of low-dose oral spironolactone and captopril therapy in a rat model of spontaneous hypertension and heart failure.
Topics: Administration, Oral; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Diuresis; Drug Therapy, Combination; Fibrosis; Heart Failure; Heart Ventricles; Hypertension; Hypertrophy; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Rats; Rats, Inbred SHR; Spironolactone; Time Factors; Ultrasonography | 2003 |
Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice.
Topics: Aldosterone; Animals; Apolipoproteins E; Arteriosclerosis; Aryldialkylphosphatase; Blood Pressure; Eplerenone; Free Radical Scavengers; Lipid Peroxidation; Lipids; Macrophages, Peritoneal; Mice; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Spironolactone; Superoxides; Time Factors | 2003 |
Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling.
Topics: Aldosterone; Animals; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Matrix; Heart; Hydralazine; Intercellular Adhesion Molecule-1; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Thiobarbituric Acid Reactive Substances; Vasodilator Agents | 2003 |
Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Eplerenone; Female; Fibrosis; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Heart Failure; Hydroxysteroid Dehydrogenases; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Myocardium; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Up-Regulation; Ventricular Dysfunction, Left | 2003 |
Nongenomic vascular action of aldosterone in the glomerular microcirculation.
Topics: Aldosterone; Animals; Arterioles; Calcium Channel Blockers; Capillaries; Cycloheximide; Dactinomycin; Endothelium, Vascular; In Vitro Techniques; Kidney Glomerulus; Male; Mineralocorticoid Receptor Antagonists; Neomycin; Protein Synthesis Inhibitors; Rabbits; Spironolactone; Vascular Resistance; Vasoconstriction | 2003 |
Efficacy of screening for primary aldosteronism by adrenocortical scintigraphy without discontinuing antihypertensive medication.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Biomarkers; Female; Humans; Hyperaldosteronism; Japan; Male; Mass Screening; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Radionuclide Imaging; Renin; Retrospective Studies; Spironolactone; Statistics as Topic; Treatment Outcome | 2003 |
Early aldosterone up-regulated genes: new pathways for renal disease?
Topics: Aldosterone; Blotting, Northern; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; GADD45 Proteins; Gene Expression Profiling; Hormone Antagonists; Humans; Immediate-Early Proteins; Intracellular Signaling Peptides and Proteins; Kidney Diseases; Mifepristone; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Transcription Factor CHOP; Transcription Factors; Up-Regulation | 2003 |
The use of a steroidal spirolactone in the treatment of ascites in hepatic cirrhosis.
Topics: Aldosterone; Ascites; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1958 |
Progestational activity of certain steroid-17-spirolactones.
Topics: Aldosterone; Mineralocorticoid Receptor Antagonists; Pregnanes; Progesterone; Spironolactone | 1958 |
Studies on new diuretic compounds: spirolactone and chlorothiazide.
Topics: Acetazolamide; Aldosterone; Chlorothiazide; Diuretics; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 1958 |
Effect of spirolactone SC 8109 on renal function in normal human subjects.
Topics: Aldosterone; Diuretics; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone; Urinary Tract Physiological Phenomena | 1959 |
Acute effects of corticosteroid mixtures and the 17-spirolactone SC-8109 on sodium, potassium, and water excretion in adrenalectomized, water-loaded rats.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biological Transport; Body Fluids; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone; Water | 1960 |
[Conn's syndrome treated with spirolactone].
Topics: Adrenal Cortex; Adrenal Cortex Diseases; Aldosterone; Diuretics; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[The effect of spirolactone SC-9420 in a case of secondary aldosteronism].
Topics: Aldosterone; Diuretics; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Pure nephrotic syndrome treated with spirolactone in the course of a Besnier-Boeck-Schaumann disease with pulmonary, hepatic and osseous involvement].
Topics: Aldosterone; Bone and Bones; Diuretics; Liver; Mineralocorticoid Receptor Antagonists; Nephrotic Syndrome; Sarcoidosis; Spironolactone | 1961 |
[Treatment of edema in liver cirrhosis with a spirolactone, aldactone].
Topics: Aldosterone; Diuretics; Edema; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
[Study of the action of spirolactone in edematous alcoholic cirrhosis].
Topics: Aldosterone; Diuretics; Edema; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
Spironolactone in hypertensive patients. Oligemic and antihypertensive effects.
Topics: Aldosterone; Antihypertensive Agents; Blood Volume; Diuretics; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[First trials of treatment of the edematous syndrome in liver cirrhoses with spirolactones. (Apropos of 11 cases)].
Topics: Aldosterone; Diuretics; Edema; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone; Syndrome | 1961 |
Spironolactone in the treatment of myasthenia gravis.
Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Spironolactone | 1961 |
[Aldosterone-antagonistic spirolactones. II. Clinical aspects].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Hormone Antagonists; Lactones; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Studies on the metabolic effects of spironolactone in man.
Topics: Aldosterone; Diuretics; Humans; Male; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
Studies on cation transport in cold-stored human erythrocytes. II. Effect of a steroidal antagonist of aldosterone (SC 9420) on sodium and potassium transfer.
Topics: Aldosterone; Cations; Cold Temperature; Cryopreservation; Erythrocytes; Humans; Ion Transport; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Sodium, Dietary; Spironolactone | 1961 |
[On the pharmacotherapy with spirolactones].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Initial results in the spirolactone treatment of 2 cases of the edematous syndrome with secondary aldosteronism].
Topics: Aldosterone; Diuretics; Edema; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone; Syndrome | 1960 |
[First results in the use of aldactone in 15 cases of ascitic cirrhosis].
Topics: Aldosterone; Diuretics; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
Effect of a steroid spirolactone on the cardiovascular changes produced by renal ischemia.
Topics: Aldosterone; Cardiovascular System; Diuretics; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Spironolactone used with mercaptomerin in the treatment of congestive cardiac failure.
Topics: Aldosterone; Diuretics; Heart Failure; Mineralocorticoid Receptor Antagonists; Organomercury Compounds; Spironolactone | 1961 |
Primary aldosteronism. The value of spironolactone in diagnosis.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Aldosterone; Humans; Hyperaldosteronism; Lactones; Spironolactone | 1961 |
A comparison of the properties of chlorothiazide, spironolactone and a combination of both as diuretic agents.
Topics: Aldosterone; Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
[Spirolactones: a new diuretic principle. The author's preliminary experience].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
Periodic paralysis with response to spironolactone.
Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Paralysis; Potassium; Spironolactone | 1961 |
[Idiopathic edema and its treatment by aldosterone inhibitors. Effects of the spirolactone SC-9420].
Topics: Aldosterone; Edema; Lactones; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Diuretic properties of a spirolactone].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Steroidal spirolactones and renal function.
Topics: Aldosterone; Diuretics; Electrolytes; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Pregnanes; Spironolactone; Urinary Tract Physiological Phenomena | 1960 |
[The aldosterone-antagonistic spirolactone. I. Pharmacology].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Hormone Antagonists; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
[Aldosterone and spirolactone].
Topics: Aldosterone; Diuretics; Edema; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Trials of treatment of cirrhotic ascites with a spirolactone. Apropos of 7 cases].
Topics: Aldosterone; Ascites; Diuretics; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
Spironolactone (Aldactone) therapy for ascites due to cirrhosis of the liver.
Topics: Aldosterone; Ascites; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Use of spironolactone in renal edema. Effectiveness and association with hyperkalemia.
Topics: Aldosterone; Diuretics; Edema; Humans; Hyperkalemia; Kidney; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone | 1961 |
[On the therapeutic use of spirolactones].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Antiarrhythmic activity of various steroidal spirolactones in dogs.
Topics: Aldosterone; Animals; Anti-Arrhythmia Agents; Dogs; Humans; Mineralocorticoid Receptor Antagonists; Pregnanes; Spironolactone | 1960 |
[Use of spironolactone in 2 cases of ascitic alcoholic cirrhosis refractory to the usual treatment].
Topics: Aldosterone; Humans; Liver Cirrhosis, Alcoholic; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Introduction; spirolactones].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Treatment of edema with an orally administered spirolactone.
Topics: Aldosterone; Edema; Lactones; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
[Spirolactones in the treatment of ascitic cirrhoses (26 cases)].
Topics: Aldosterone; Diuretics; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1961 |
[Aldosterone and spirolactones].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Use of the combination of saluretics and aldosterone inhibitors (SC 9420 and SU 4885) in the treatment of refractory edema].
Topics: Aldosterone; Diuretics; Edema; Metyrapone; Mineralocorticoid Receptor Antagonists; Pyridines; Spironolactone | 1960 |
[Apparently irreducible cardiac edema. Remarkable effect of a spirolactone].
Topics: Aldosterone; Diuretics; Edema, Cardiac; Heart Failure; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
Spirolactone diuretics.
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Apropos of a pure lipoid nephrosis in a child treated with spirolactone].
Topics: Aldosterone; Child; Diuretics; Infant; Mineralocorticoid Receptor Antagonists; Nephrosis, Lipoid; Nephrotic Syndrome; Spironolactone | 1961 |
[Spirolactone. Its use in the treatment of cardiac and cirrhotic edema. Apropos of 6 case reports].
Topics: Aldosterone; Diuretics; Edema; Heart Failure; Liver Cirrhosis; Spironolactone | 1961 |
[Spirolactones. Their use in the treatment of cardiac and cirrhotic edemas (apropos of 6 case reports)].
Topics: Aldosterone; Diuretics; Edema; Heart Failure; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
The diuretic effect of spirolactone SC-9420 in a case of secondary aldosteronism.
Topics: Aldosterone; Diuretics; Hyperaldosteronism; Spironolactone | 1960 |
Effect of heparinoid and spirolactone on the renal excretion of sodium and aldosterone.
Topics: Aldosterone; Diuretics; Heparin; Heparinoids; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Renal Elimination; Sodium; Sodium, Dietary; Spironolactone | 1960 |
[Spirolactone, an aldosterone-antagonistic steroid. Illustration of its effects on a patient with liver cirrhosis].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone; Steroids | 1960 |
Use of spironolactone and hydrochlorothiazide in treatment of oedema.
Topics: Aldosterone; Chlorothiazide; Diuretics; Edema; Hydrochlorothiazide; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
Stop flow analysis of aldosterone and steroidal antagonist SC-8109 on renal tubular sodium transport kinetics.
Topics: Aldosterone; Diuretics; Humans; Ion Transport; Kidney; Kinetics; Mineralocorticoid Receptor Antagonists; Sodium; Sodium, Dietary; Spironolactone | 1960 |
[Effect of SC 9420, mercurial diuretic and hydrochlorothiazide on electrolyte excretion in liver cirrhosis].
Topics: Aldosterone; Chlorothiazide; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organomercury Compounds; Spironolactone | 1959 |
[A study of the natriuretic action of an antagonist of aldosterone: spirolactone SC 9420 (aldactone)].
Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Musculoskeletal Physiological Phenomena; Spironolactone | 1960 |
The SPIROLACTONES.
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
[Cirrhotic edemas and spironolactone].
Topics: Aldosterone; Diuretics; Edema; Edetic Acid; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
Effect of aldactone, an antiminera-locorticoid steroid spironolactone, on inflammation.
Topics: Aldosterone; Diuretics; Hydrocortisone; Inflammation; Mineralocorticoid Receptor Antagonists; Spironolactone; Steroids | 1961 |
[Effect of particle sizes and detergents on the absorption of spironolactone from the gastrointestinal tract].
Topics: Aldosterone; Detergents; Diuretics; Gastrointestinal Tract; Humans; Mineralocorticoid Receptor Antagonists; Particle Size; Spironolactone | 1962 |
[Spirolactones in the treatment of ascitogenic hepatic cirrhosis. Clinical and biological effects].
Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Combined treatment with a spirolactone derivative and a saluretic, a contribution to edema therapy].
Topics: Aldosterone; Combined Modality Therapy; Diuretics; Edema; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Therapeutic acquisitions. Spironolactone (aldactone)].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Pediatrics; Spironolactone | 1962 |
The effects of spironolactone and chlorthalidone on arterial pressure.
Topics: Aldosterone; Arterial Pressure; Blood Pressure; Chlorthalidone; Diuretics; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Treatment of the edematigenous syndrome with spirolactone inhibitors of aldosterone].
Topics: Aldosterone; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spironolactone; Syndrome | 1962 |
Effects of steroid-17-spirolactones on aldosterone secretion, excretion, and metabolism in man.
Topics: Aldosterone; Biological Transport; Body Fluids; Cell Communication; Humans; Lipid Metabolism; Spironolactone | 1961 |
[Spirolactone (Aldactone) in ascites caused by liver cirrhosis].
Topics: Aldosterone; Ascites; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
The aldosterone blocking effects of spirolactones.
Topics: Aldosterone; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Spirolactones].
Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Conn's syndrome with adrenocortical adenoma. Action of spirolactone, SC-9420].
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Aldosterone; Diuretics; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
Observations on the mechanism of action of steroidal spirolactones.
Topics: Aldosterone; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[The behavior of the water-mineral balance and urinary aldosterone in diabetes insipidus after administration of aldosterone and spironolactone].
Topics: Aldosterone; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diabetes Mellitus; Diuretics; Humans; Mineral Waters; Minerals; Spironolactone; Water; Water-Electrolyte Balance | 1961 |
[Synergistic therapy of edema with spirolactone and chlorothiazide].
Topics: Aldosterone; Chlorothiazide; Edema; Edetic Acid; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Observations on the use of an aldosterone antagonist (aldactone) in the therapy of water retention].
Topics: Aldosterone; Diuretics; Edema; Edetic Acid; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma.
Topics: Aldosterone; Fluorescence; Fluorometry; Humans; Lactones; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[On the use of spirolactone-polysorbate 80].
Topics: Aldosterone; Diuretics; Edetic Acid; Humans; Mineralocorticoid Receptor Antagonists; Polysorbates; Spironolactone | 1962 |
[The antiphlogistic effect and mechanism of action of spironolactone].
Topics: Aldosterone; Diuretics; Inflammation; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Our experiences with the aldosterone blocking agent, aldactone in obstetrics].
Topics: Aldosterone; Body Fluids; Diuretics; Female; Humans; Mineralocorticoid Receptor Antagonists; Obstetrics; Potassium; Pre-Eclampsia; Pregnancy; Sodium; Spironolactone; Urinalysis | 1962 |
[Diuretic and saluretic action of an aldosterone antagonist (spirolactone, SC-9420) associated with an iso-indoline derivative (Hygroton) in refractory cardiac edema].
Topics: Aldosterone; Antihypertensive Agents; Chlorthalidone; Diuretics; Edema, Cardiac; Heart Failure; Indoles; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
Studies on the inotropic action of aldosterone on isolated cardiac tissue preparations; including the effects of pH, ouabain and SC-8109.
Topics: Aldosterone; Diuretics; Heart; Hydrogen-Ion Concentration; Mineralocorticoid Receptor Antagonists; Ouabain; Spironolactone; Strophanthins | 1962 |
Effect of cortisone and spirolactone on potassium excreting action of aldosterone and desoxycorticosterone.
Topics: Aldosterone; Animals; Cortisone; Desoxycorticosterone; Diuretics; Humans; Potassium; Poultry; Spironolactone | 1962 |
[Treatment of the hydrosaline retention in hepatic cirrhosis with spironolactone].
Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone; Water-Electrolyte Balance | 1961 |
[Treatment of the nephrotic syndrome with a spirolactone].
Topics: Aldosterone; Mineralocorticoid Receptor Antagonists; Nephrotic Syndrome; Spironolactone | 1961 |
[Methods of treatment of edema. Classification of diuretics. Salidiuretics, corticoids, spirolactones].
Topics: Adrenal Cortex Hormones; Aldosterone; Diuretics; Edema; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Spirolactones in medical practice].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
The actions of a spirolactone and two related compounds in hypophysectomized rats.
Topics: Aldosterone; Animals; Hypophysectomy; Ions; Potassium; Rats; Sodium; Sodium, Dietary; Spironolactone; Steroids | 1963 |
Actions of two aldosterone antagonists on cat perfused kidneys.
Topics: Aldosterone; Animals; Cats; Glomerular Filtration Rate; Kidney; Lactones; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone | 1963 |
Dynamic changes in sweat electrolyte composition induced by heat stress as an indication of acclimatization and aldosterone activity.
Topics: Acclimatization; Aldosterone; Electrolytes; Heat Stress Disorders; Hot Temperature; Humans; Ions; Potassium; Sodium; Sodium, Dietary; Spironolactone; Sweat | 1963 |
Significance of aldosterone antagonism in the treatment of edema and ascites.
Topics: Aldosterone; Antihypertensive Agents; Ascites; Chlorothiazide; Diuretics; Edema; Humans; Hydrochlorothiazide; Lactones; Mineralocorticoid Receptor Antagonists; Spiro Compounds; Spironolactone | 1962 |
[Aldosterone and the water-electrolyte balance].
Topics: Aldosterone; Humans; Kidney; Spironolactone; Sweat Glands; Water-Electrolyte Balance | 1963 |
[On aldosterone inhibitors: comparison of the actions of progesterone and spironolactone].
Topics: Aldosterone; Diuresis; Humans; Ions; Mineralocorticoid Receptor Antagonists; Potassium; Progesterone; Sodium; Sodium, Dietary; Spironolactone | 1963 |
Effect of aldosterone on the metabolism of magnesium.
Topics: Adrenalectomy; Aldosterone; Humans; Hyperaldosteronism; Magnesium; Potassium; Spironolactone | 1962 |
Human assay of electrolyte-active steroids and their antagonists.
Topics: Aldosterone; Electrolytes; Fludrocortisone; Humans; Potassium; Pterins; Sodium; Sodium, Dietary; Spironolactone; Steroids | 1962 |
Mechanism of action and use of aldosterone-blocking steroids in edema.
Topics: Addison Disease; Adrenal Insufficiency; Aldosterone; Edema; Humans; Hypoadrenocorticism, Familial; Spironolactone; Steroids | 1962 |
[Influence of an aldosterone inhibitor and antagonist on the sodium concentration of sweat. Extra-renal effect of spirolactones].
Topics: Aldosterone; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Sodium; Sodium, Dietary; Spironolactone; Sweat | 1962 |
Aldosterone and aqueous humor dynamics.
Topics: Aldosterone; Aqueous Humor; Diet; Sodium; Sodium, Dietary; Spironolactone | 1963 |
[On the use of spironolactone for increased diuresis].
Topics: Aldosterone; Diuresis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[The clinical importance of spironolactones, peripheral antagonists of aldosterone].
Topics: Aldosterone; Edema; Humans; Hyperaldosteronism; Spironolactone; Water-Electrolyte Balance | 1961 |
[Treatment of 12 cases of so-called irreversible cardiac edemas by the antagonistic aldosterone medication].
Topics: Aldosterone; Edema, Cardiac; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1963 |
[Pressure of the tissues in various post-infarct complications and under the influence of aldosterone, spirolactone and saline administration].
Topics: Aldosterone; Heart Failure; Humans; Myocardial Infarction; Sodium Chloride; Spironolactone | 1962 |
Interaction of aldosterone with liver and kidney cell membranes and subcellular fractions of kidney.
Topics: Aldosterone; Cell Membrane; Humans; Kidney; Liver; Spironolactone; Subcellular Fractions | 1963 |
Steroidportein interactions. IX. Interaction of aldosterone with human serum proteins in competition with spirolactones and other steroids.
Topics: Adrenal Cortex Hormones; Aldosterone; Blood Proteins; Dexamethasone; Humans; Progesterone; Spironolactone | 1962 |
[Preliminary observation on the clinical use of aldosterone antagonistic drugs (spironolactone) in edemigenic syndromes].
Topics: Aldosterone; Diuretics; Edema; Heart Failure; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone; Syndrome | 1962 |
[Diuretic effect of spironolactone (Sc-9420) in patients with cirrhosis of the liver with ascites].
Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[PATHOGENETIC ASPECTS AND THERAPEUTIC PROBLEMS IN CONGESTIVE INSUFFICIENCY OF THE GREATER CIRCULATION].
Topics: Aldosterone; Animals; Blood Pressure; Blood Pressure Determination; Blood Proteins; Capillary Permeability; Diet; Diet Therapy; Digitalis Glycosides; Diuretics; Heart Failure; Heart Function Tests; Hematopoiesis; Humans; Iron; Leeches; Liver Function Tests; Metabolism; Pathology; Sparteine; Spironolactone; Strophanthins; Water-Electrolyte Balance | 1963 |
MALIGNANT HYPERTENSION AND ALDOSTERONE SECRETION. INFLUENCE OF REVERSAL AND PROGRESSION OF THE SYNDROME IN TWO CASES.
Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Hypertension, Malignant; Spironolactone; Uremia; Water-Electrolyte Balance | 1963 |
THE EFFECTS OF HEMORRHAGE AND HORMONES ON THE PARTITION OF BODY WATER. III. THE EFFECTS OF HEMORRHAGE AND CORTICOSTEROIDS ON FLUID PARTITION IN THE ADRENALECTOMIZED DOG.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Blood Pressure; Blood Volume; Body Fluids; Body Water; Bromine; Capillary Permeability; Desoxycorticosterone; Dogs; Glucocorticoids; Hemorrhage; Hydrocortisone; Radioisotopes; Research; Spironolactone; Splenectomy; Ureteral Obstruction | 1963 |
CONTENT AND UPTAKE OF SODIUM AND POTASSIUM IN BONE. INFLUENCE OF ADRENALECTOMY, ALDOSTERONE, DESOXYCORTICOSTERONE AND SPIRONOLACTONE.
Topics: Adrenalectomy; Aldosterone; Blood Chemical Analysis; Bone and Bones; Desoxycorticosterone; Metabolism; Pharmacology; Potassium; Potassium Isotopes; Rats; Research; Sodium; Sodium Isotopes; Sodium, Dietary; Spironolactone | 1963 |
[ON USE OF THE BLOCKING AGENT ALDOSTERONE].
Topics: Aldosterone; Aortic Valve; Diuretics; Heart Failure; Humans; Hyperaldosteronism; Mitral Valve Insufficiency; Potassium; Pulmonary Valve Stenosis; Sodium; Spironolactone | 1963 |
EXPERIMENTAL STUDIES ON THE RELATIONSHIP BETWEEN ENDOCRINE ORGANS AND HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS. II. EFFECTS OF VARIOUS HORMONES ON BLOOD PRESSURE.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Arginine Vasopressin; Blood Pressure; Body Weight; Cortisone; Desoxycorticosterone; Hormones; Hypertension; Norepinephrine; Progesterone; Rats; Rats, Inbred SHR; Research; Sodium Chloride; Spironolactone; Stilbenes; Testosterone; Thyroid Hormones; Vasopressins | 1963 |
EFFECT OF AN ALDOSTERONE ANTAGONIST (SPIRONOLACTONE) ON PATIENTS WITH SEVERE CONGESTIVE HEART FAILURE.
Topics: Aldosterone; Antihypertensive Agents; Body Fluids; Diuresis; Diuretics; Female; Geriatrics; Heart Failure; Humans; Hyperkalemia; Hyponatremia; Male; Mineralocorticoid Receptor Antagonists; Natriuresis; Potassium; Spironolactone; Urine; Water-Electrolyte Balance | 1963 |
ALDOSTERONE AND THE EDEMA OF CONGESTIVE HEART FAILURE.
Topics: Aldosterone; Chromatography; Diuretics; Edema; Geriatrics; Heart Diseases; Heart Failure; Hypertension; Myocarditis; Organomercury Compounds; Pterins; Pulmonary Heart Disease; Rheumatic Heart Disease; Spironolactone; Syphilis; Syphilis, Cardiovascular; Triamterene; Urine | 1964 |
[OUR EXPERIENCE IN THE TREATMENT OF PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS WITH ALDOSTERONE INHIBITORS].
Topics: Aldosterone; Humans; Liver Cirrhosis; Metyrapone; Mineralocorticoid Receptor Antagonists; Prednisone; Spironolactone | 1963 |
ALDOSTERONE AND SWEAT GLAND FUNCTION.
Topics: Acclimatization; Aldosterone; Dehydration; Hot Temperature; Humans; Hyperaldosteronism; Physiology; Potassium; Sodium Chloride; Spironolactone; Sweat; Sweat Glands; Sweating | 1963 |
VARIATIONS IN PLASMA RENIN CONCENTRATION IN SEVERAL PHYSIOLOGICAL AND PATHOLOGICAL STATES.
Topics: Addison Disease; Aldosterone; Angiotensins; Blood Chemical Analysis; Hypertension; Hypokalemia; Liver Cirrhosis; Pathology; Physiology; Pregnancy; Renal Artery Obstruction; Renin; Sodium Chloride; Spironolactone | 1964 |
HYPERTENSION DUE TO RENAL ARTERY OCCLUSION SIMULATING PRIMARY ALDOSTERONISM.
Topics: Aldosterone; Angiotensins; Blood Chemical Analysis; Blood Pressure; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney; Potassium; Progesterone; Renal Artery; Renal Artery Obstruction; Renin; Sodium; Spironolactone | 1964 |
[CONTRIBUTION TO THE PROBLEM OF IDIOPATHIC EDEMA].
Topics: Aldosterone; Diuretics; Edema; Metyrapone; Mineralocorticoid Receptor Antagonists; Sodium Chloride; Spironolactone; Water-Electrolyte Balance | 1963 |
[CHANGES OF THE ALDOSTERONE EFFECT INDUCED BY SPIRONOLACTONE AND TRIAMTERENE. STUDY OF THE POSSIBLE MECHANISM OF ACTION].
Topics: Aldosterone; Diuretics; Electrolytes; Erythrocytes; Pharmacology; Pterins; Rats; Research; Spironolactone; Triamterene | 1963 |
[EFFECTS OF HYDROCHLOROTHIAZIDE ASSOCIATED WITH ALDOSTERONE IN THE THERAPY OF NEPHROTIC EDEMA. I. CLINICAL RESULTS AND STUDY OF WATER AND SALT METABOLISM IN 3 CASES].
Topics: Adrenocorticotropic Hormone; Aldosterone; Child; Edema; Glomerulonephritis; Humans; Hydrochlorothiazide; Metabolism; Mineralocorticoid Receptor Antagonists; Nephrosis; Nephrotic Syndrome; Prednisolone; Sodium Chloride; Spironolactone; Water; Water-Electrolyte Balance | 1963 |
[NATRIURETIC DRUGS].
Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Diuretics; Heart Failure; Hydrochlorothiazide; Hydroflumethiazide; Hypertension; Kidney Tubules; Metyrapone; Mineralocorticoid Receptor Antagonists; Natriuresis; Pharmacology; Physiology; Spironolactone; Sulfanilamide; Sulfanilamides; Thiazines | 1963 |
[CHRONIC IDIOPATHIC HYPOKALEMIA WITH HYPERKALIURIA IN CHILDREN].
Topics: Adrenal Glands; Aldosterone; Blood Platelet Disorders; Blood Platelets; Child; Corticosterone; Dwarfism; Fatigue; Genetics, Medical; Humans; Hyperlipidemias; Hypocalcemia; Hypokalemia; Hyponatremia; Kidney; Pathology; Polyuria; Potassium; Spironolactone; Thirst; Urine | 1964 |
ADRENAL CORTICOSTEROIDS AND INTRAOCULAR PRESSURE.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Intraocular Pressure; Pharmacology; Rabbits; Research; Spironolactone; Tonometry, Ocular | 1964 |
THE DIAGNOSTIC IMPLICATION OF RESTRICTION OF SALT INTAKE AND ADMINISTRATION OF VARIOUS DRUGS IN PRIMARY ALDOSTERONISM.
Topics: Aldosterone; Biomedical Research; Cushing Syndrome; Desoxycorticosterone; Diagnosis, Differential; Diet, Sodium-Restricted; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Kidney; Pharmaceutical Preparations; Potassium; Spironolactone; Urine | 1964 |
[PLACE OF ALDACTONE IN THE THERAPY OF EDEMA].
Topics: Aldosterone; Edema; Heart Failure; Humans; Hyperaldosteronism; Liver Cirrhosis; Spironolactone | 1964 |
[ON A FEW EXPERIMENTAL ARGUMENTS IN FAVOR OF THE EXISTENCE OF A SODIUM RETENTION FACTOR OTHER THAN ALDOSTERONE IN THE RAT].
Topics: Aldosterone; Metabolism; Pharmacology; Rats; Research; Sodium; Spironolactone | 1964 |
[ALDOSTERONE AND SPIROLACTONES IN THE CLINICAL TREATMENT OF INTERNAL DISEASES (REVIEW OF THE LITERATURE AND ANALYSIS OF PERSONAL CASES)].
Topics: Albuminuria; Aldosterone; Blood; Cardiovascular Diseases; Drug Therapy; Humans; Hyperaldosteronism; Hypercholesterolemia; Hypertension; Mineralocorticoid Receptor Antagonists; Natriuresis; Nephrosis; Nephrosis, Lipoid; Nephrotic Syndrome; Potassium; Spironolactone; Urine; Water-Electrolyte Balance | 1963 |
[PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF SECONDARY ALDOSTERONISM AND ITS TREATMENT].
Topics: Adrenocorticotropic Hormone; Aldosterone; Ascites; Body Fluids; Classification; Dexamethasone; Extracellular Space; Hyperaldosteronism; Hypertension; Hypertension, Malignant; Kidney Tubules; Liver Cirrhosis; Metyrapone; Mineralocorticoid Receptor Antagonists; Natriuresis; Nephrotic Syndrome; Pathology; Pharmacology; Physiology; Potassium; Sodium; Spironolactone; Toxicology; Triparanol | 1964 |
CHANGES IN THE URINARY EXCRETION OF CALCIUM AFTER INTRAVENOUS INJECTION OF ALDOSTERONE.
Topics: Aldosterone; Body Fluids; Calcium; Calcium, Dietary; Creatine; Creatinine; Heart Defects, Congenital; Humans; Injections; Injections, Intravenous; Natriuresis; Pharmacology; Potassium; Spironolactone; Urine | 1964 |
MINERALOCORTICOID-BLOCKING PROPERTIES OF A PROGESTERONE-LIKE DERIVATIVE (SC-11835).
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Dogs; Hydrochlorothiazide; Kidney; Metabolism; Mineralocorticoids; Pharmacology; Potassium; Progesterone; Progestins; Rats; Research; Sodium; Spironolactone; Urine | 1964 |
PRIMARY ALDOSTERONISM: OBSERVATIONS IN SIX CASES AND REVIEW OF DIAGNOSTIC PROCEDURES.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Diabetes Mellitus; Diagnosis, Differential; Humans; Hyperaldosteronism; Hypertension; Kidney Function Tests; Metabolism; Neurologic Manifestations; Potassium Deficiency; Prognosis; Sodium; Spironolactone; Urine; Water-Electrolyte Balance | 1964 |
AN OESTROGENIC EFFECT AS A COMPONENT OF THE STRESS SYNDROME.
Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Castration; Epinephrine; Estrogens; Female; Humans; Hydrocortisone; Hypophysectomy; Hypothalamus; Ovary; Pharmacology; Phentolamine; Physiology; Progesterone; Rats; Research; Spironolactone; Stress, Physiological; Sympathetic Nervous System; Testosterone | 1964 |
BIOLOGICAL ACTION OF ALDOSTERONE IN VITRO.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Biological Transport; Bufonidae; Cell Membrane Permeability; Corticosterone; Desoxycorticosterone; Hydrocortisone; In Vitro Techniques; Mucous Membrane; Pharmacology; Research; Sodium; Sodium Isotopes; Spironolactone; Urinary Bladder | 1964 |
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME.
Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Angiography; Blood; Catheterization; Chlorides; Contrast Media; Humans; Hydrocortisone; Hyperaldosteronism; Kidney Function Tests; Phlebography; Potassium; Spironolactone; Surgical Procedures, Operative; Veins | 1964 |
STEROIDAL ALDOSTERONE BLOCKERS. 8. HYDROXYLATED STEROIDAL 17-SPIROLACTONES.
Topics: Aldosterone; Chemistry, Pharmaceutical; Fungi; Hydroxylation; Mineralocorticoid Receptor Antagonists; Pregnanes; Research; Spironolactone; Steroids | 1964 |
ENDOCRINE ASPECTS OF THE METABOLIC RESPONSE TO SURGICAL OPERATION.
Topics: Adrenal Glands; Adrenal Medulla; Aldosterone; Blood Chemical Analysis; Diuresis; Humans; Hydrocortisone; Natriuresis; Nitrogen; Pancreas; Pharmacology; Pituitary Gland; Pituitary Gland, Posterior; Potassium; Spironolactone; Surgical Procedures, Operative; Thyroid Gland; Urine | 1964 |
DECREASED EFFECTIVENESS OF ALDOSTERONE ON ACTIVE SODIUM TRANSPORT BY THE ISOLATED TOAD BLADDER IN THE PRESENCE OF OTHER STEROIDS.
Topics: Aldosterone; Animals; Anura; Biological Transport; Biological Transport, Active; Bufonidae; Corticosterone; Estradiol; Hydrocortisone; Permeability; Pharmacology; Progesterone; Research; Sodium; Spironolactone; Urinary Bladder | 1964 |
[EFFECT OF A SPIRONOLACTONE ALDOSTERONE INHIBITOR AND CHLOROTHIAZIDE ON WATER AND ELECTROLYTE EXCRETION IN LIVER DISEASES].
Topics: Aldosterone; Biomedical Research; Body Fluids; Chlorothiazide; Electrolytes; Liver Diseases; Mineralocorticoid Receptor Antagonists; Pharmacology; Spironolactone; Urine; Water; Water-Electrolyte Balance | 1964 |
[CHARACTERIZATION OF THE DIURETIC EFFECT OF COUMARIN-3-GLYOXYLIC ALDEHYDE].
Topics: Aldehydes; Aldosterone; Body Fluids; Carbon Tetrachloride; Chlorothiazide; Coumarins; Diuretics; Electrolytes; Pharmacology; Rats; Research; Spironolactone; Urine | 1963 |
[EXTRARENAL EFFECT OF ALDOSTERONE AND ITS INHIBITION BY SPIROLACTONE].
Topics: Aldosterone; Pharmacology; Spironolactone; Water-Electrolyte Balance | 1964 |
ALDOSTERONE AND THE EDEMA OF CONGESTIVE HEART FAILURE.
Topics: Aldosterone; Drug Therapy; Edema; Heart Failure; Humans; Metabolism; Spironolactone | 1965 |
[EXTRARENAL EFFECTS OF ALDOSTERONE AND SPIROLACTONE].
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Liver; Muscles; Myocardium; Pharmacology; Rats; Research; Spironolactone; Water-Electrolyte Balance | 1964 |
IDIOPATHIC EDEMA ND HYPERALDOSTERONURIA: POSTURAL VENOUS PLASMA POOLING.
Topics: Adolescent; Aldosterone; Angiotensins; Blood Pressure; Body Weight; Drug Therapy; Edema; Ephedrine; Humans; Hyperaldosteronism; Iodine Isotopes; Mephentermine; Metyrapone; Mineralocorticoid Receptor Antagonists; Natriuresis; Norepinephrine; Posture; Potassium; Sodium; Spironolactone; Toxicology; Urine | 1965 |
[APPLICATION OF ANTI-ALDOSTERONE DIURETICS TO THE TREATMENT OF LOCALIZED EDEMA OF THE EXTREMITIES IN CANCER PATIENTS].
Topics: Aldosterone; Breast Neoplasms; Diuretics; Edema; Extremities; Female; Humans; Mastectomy; Mineralocorticoid Receptor Antagonists; Neoplasms; Postoperative Complications; Spironolactone; Toxicology; Uterine Neoplasms | 1965 |
ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS.
Topics: Adrenalectomy; Aldosterone; Anuria; Chlorothiazide; Desoxycorticosterone; Diabetes Insipidus; Diazoxide; Diuresis; Diuretics; Dogs; Kidney Function Tests; Organomercury Compounds; Pharmacology; Research; Sodium Chloride; Spironolactone | 1965 |
[RENAL CLEARANCE OF FREE ALDOSTERONE BEFORE AND AFTER APPLICATION OF AN ALDOSTERONE ANTAGONIST].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Humans; Kidney Function Tests; Mineralocorticoid Receptor Antagonists; Spironolactone | 1964 |
[ISOTOPIC STUDY OF THE MECHANISM OF ACTION OF ALDOSTERONE ANTAGONISTS].
Topics: Aldosterone; Body Fluids; Fluids and Secretions; Metabolism; Mineralocorticoid Receptor Antagonists; Pharmacology; Research; Spironolactone; Tritium; Urine | 1964 |
A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Cardiac Glycosides; Desoxycorticosterone; Digitoxin; Dogs; Heart; Pentobarbital; Pharmacology; Research; Spironolactone; Structure-Activity Relationship | 1965 |
Hyperaldo-steronism in liver disease. The treatment of refractory ascites by adrenalectomy and by the administration of spirolactones.
Topics: Adrenalectomy; Aldosterone; Ascites; Humans; Lactones; Liver Diseases; Spironolactone | 1960 |
Effects of a spirolactone (SC-8109) in primary mineralocorticoid excess.
Topics: Adrenal Cortex Hormones; Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Spironolactone | 1960 |
Experience with spirolactone and prednisone in the combined-drug treatment of resistant edema.
Topics: Aldosterone; Combined Modality Therapy; Diuretics; Edema; Manipulation, Osteopathic; Mineralocorticoid Receptor Antagonists; Prednisone; Spironolactone | 1960 |
Effects of antialdosterone compounds (spirolactones) on the antinatruresis of the upright position in pregnancy.
Topics: Aldosterone; Body Fluids; Female; Humans; Mineralocorticoid Receptor Antagonists; Pregnancy; Sodium; Spironolactone; Urinalysis | 1960 |
[Study with spirolactone, peripheral inhibitor of aldosterone].
Topics: Aldosterone; Humans; Lactones; Spironolactone | 1960 |
Protection by a steroid-spirolactone against certain types of cardiac necroses.
Topics: Aldosterone; Heart; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Necrosis; Spironolactone | 1960 |
Resistant ascites treated by combined diuretic therapy (spironolactone, mannitol, and chlorothiazide).
Topics: Aldosterone; Ascites; Chlorothiazide; Diuretics; Mannitol; Mineralocorticoid Receptor Antagonists; Spironolactone | 1960 |
Effect of aldosterone-antagonist, SC 8109, on the secretion of aldosterone in normal rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Mineralocorticoid Receptor Antagonists; Rats; Spironolactone | 1959 |
[Preliminary note on the use of a spirolactone in the treatment of myasthenia].
Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Muscle Weakness; Myasthenia Gravis; Spironolactone | 1962 |
Influence of spironolactone in modifying the renal electrolyte effects of hydrochlorothiazide in laboratory animals.
Topics: Aldosterone; Animals; Animals, Laboratory; Chlorothiazide; Electrolytes; Hydrochlorothiazide; Kidney; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone | 1962 |
[Influence of spirolactones on manifestations of experimental renal hypertension].
Topics: Aldosterone; Diuretics; Hypertension; Hypertension, Renal; Kidney; Leadership; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Aldosterone-antagonistic spirolactones. Principles for their indication and use].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Clinical use of spirolactone SC-9420 "Aldactone"].
Topics: Aldosterone; Diuretics; Heart Failure; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Spirolactones].
Topics: Aldosterone; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Aldostegone-antagonistic steroids as diuretics. Spironolactone in the treatment of hepatic and cardiac edemas].
Topics: Aldosterone; Diuretics; Edema, Cardiac; Edetic Acid; Heart Failure; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Prednisone; Spironolactone; Steroids | 1961 |
Effects of an aldosterone-antagonist (SC-8109) on radio-sodium (Na22) metabolism in rats with hypothalamic lesions.
Topics: Aldosterone; Animals; Antihypertensive Agents; Disease; Diuretics; Hormone Antagonists; Hypothalamus; Mineralocorticoid Receptor Antagonists; Rats; Sodium; Sodium, Dietary; Spironolactone | 1961 |
Administration of aldactone as a source of error in determination of fractionated 17-ketosteroids in urine. Preliminary report.
Topics: 17-Ketosteroids; Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Treatment of various nephrotic edemas with the combination of chlorothiazide and spirolactone].
Topics: Aldosterone; Chlorothiazide; Diuretics; Edema; Mineralocorticoid Receptor Antagonists; Nephrotic Syndrome; Spironolactone | 1961 |
The blocking by spirolactones of the actions of aldosterone and cortisol upon the human kidney.
Topics: Aldosterone; Diuretics; Humans; Hydrocortisone; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Treatment of the ascites and edema of cirrhotics by spironolactone].
Topics: Aldosterone; Ascites; Diuretics; Edema; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[The place of spirolactones in the treatment of ascitogenic cirrhosis].
Topics: Aldosterone; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1962 |
Primary aldosteronism. Preoperative preparation with spironolactone.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Aldosterone; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[On the influence of an aldosterone antagonist (SC-8109) on the absorption of sodium from the gastrointestinal tract of rats].
Topics: Aldosterone; Animals; Antihypertensive Agents; Diuretics; Gastrointestinal Tract; Mineralocorticoid Receptor Antagonists; Rats; Sodium; Sodium, Dietary; Spironolactone | 1962 |
[Tissular aldactone saliuretic inhibitor of aldosterone. Its significance in the treatment of edemas associated with secondary hyperaldosteronism].
Topics: Aldosterone; Diuretics; Edema; Edetic Acid; Hyperaldosteronism; Spironolactone | 1961 |
[Spirolactone treatment of liver cirrhosis with edema and ascites].
Topics: Aldosterone; Ascites; Edema; Edetic Acid; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Chemicals; Spironolactone | 1962 |
Effect of aldosterone antagonist (SC 9420) on periodic paralysis.
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Paralysis; Periodicity; Spironolactone | 1962 |
[Hypokalemis, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. III. Effects of spirolactone].
Topics: Aldosterone; Alkalosis; Chlorothiazide; Diuretics; Edema; Heart Failure; Mineralocorticoid Receptor Antagonists; Potassium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1962 |
[Aldactone (aldosterone antagonist SC-9, 420) in the treatment of the edemas of heart patients and cirrhotic patients. Bioclinical study].
Topics: Aldosterone; Diuretics; Edema; Heart Failure; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone; Sulfonamides | 1962 |
[Spirolactones (Aldactone)].
Topics: Aldosterone; Diuretics; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Myasthenia gravis and spironolactone].
Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Progesterone; Spironolactone | 1962 |
[Apropos of a case of myasthenia gravis improved by spirolactones].
Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Spironolactone | 1962 |
[Research on the absorption of spironolactone: determination by a spectrophotofluorimetric method and comparison of 2 different preparations in normal subjects].
Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Research; Spironolactone | 1962 |
[Observations on the effect of the aldosterone antagonist spironolactone (aldactone) in normal and toxemic pregnancy (preliminary report)].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Female; Hormone Antagonists; Humans; Mineralocorticoid Receptor Antagonists; Pre-Eclampsia; Pregnancy; Spironolactone | 1961 |
[The use of spirolactones in therapy].
Topics: Aldosterone; Diuretics; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spironolactone | 1961 |
[Study of the renal effects of the spirolactone, SC 9420, in man].
Topics: Aldosterone; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone | 1962 |
[Contribution to the treatment of essential hypertension.(Control of blood pressure, active blood volume, venous pressure, circulation time and mineral metabolism after Repicin and spirolactone medication)].
Topics: Aldosterone; Blood Circulation Time; Blood Pressure; Blood Pressure Determination; Blood Volume; Chlorothiazide; Essential Hypertension; Hypertension; Lactones; Mineralocorticoid Receptor Antagonists; Minerals; Potassium; Reserpine; Spironolactone; Venous Pressure | 1962 |
Primary aldosteronism, diagnosed by the aldosterone to renin ratio, is a common cause of hypertension.
Topics: Aldosterone; Antihypertensive Agents; Diagnostic Tests, Routine; Humans; Hyperaldosteronism; Hypertension; Mutation; Renin; Spironolactone | 2003 |
Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface.
Topics: Aldosterone; Animals; Calcium; Cell Separation; Coronary Vessels; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; Hydrogen Peroxide; Hyperaldosteronism; Leukocytes, Mononuclear; Lymphocyte Activation; Magnesium; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Tyrosine | 2003 |
Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury.
Topics: Aldosterone; Angiotensin II; Animals; Cardiovascular Diseases; Coronary Artery Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Myocardium; NG-Nitroarginine Methyl Ester; Plasminogen Activator Inhibitor 1; Proteinuria; Sodium, Dietary; Spironolactone | 2003 |
High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Aldosterone; Female; Fludrocortisone; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Male; Mass Screening; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone; Veins | 2003 |
Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Aorta; Arterioles; Benzoquinones; Calcium; Cells, Cultured; Chromones; Dactinomycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Heart Ventricles; Humans; In Vitro Techniques; Kidney; Lactams, Macrocyclic; Male; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Vasoconstriction | 2003 |
[Effects of aldosterone and spironolactone on the proliferation and collagen synthesis of hepatic stellate cells in rats].
Topics: Aldosterone; Animals; Cell Division; Collagen; Liver; Liver Cirrhosis; Rats; Spironolactone | 2003 |
Determinants of spironolactone binding specificity in the mineralocorticoid receptor.
Topics: Aldosterone; Binding, Competitive; Cloning, Molecular; Dexamethasone; Protein Conformation; Protein Structure, Tertiary; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Recombinant Fusion Proteins; Spironolactone | 2003 |
Corticosteroid effect on Caco-2 cell lipids depends on cell differentiation.
Topics: Aldosterone; Arachidonic Acid; Caco-2 Cells; Cell Differentiation; Cholesterol; Dexamethasone; Enterocytes; Fatty Acids; Humans; Lipid Metabolism; Phospholipids; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Triglycerides; Tritium | 2003 |
Endothelial cell swelling by aldosterone.
Topics: Adaptation, Physiological; Aldosterone; Cell Membrane Permeability; Cell Size; Cells, Cultured; Endothelial Cells; Humans; Nuclear Envelope; Receptors, Mineralocorticoid; Spironolactone; Umbilical Veins; Water-Electrolyte Balance | 2003 |
[Aldosterone receptor antagonists in heart failure. Rightly brought back from retirement].
Topics: Aldosterone; Clinical Trials as Topic; Eplerenone; Germany; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Survival Rate; Treatment Outcome; Ventricular Dysfunction, Left | 2003 |
Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats.
Topics: Aldosterone; Animals; Cyclic N-Oxides; Eplerenone; Hypertension; JNK Mitogen-Activated Protein Kinases; Kidney Cortex; Male; MAP Kinase Signaling System; Membrane Transport Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; NADPH Dehydrogenase; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Phosphoproteins; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium Chloride; Spin Labels; Spironolactone | 2004 |
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Topics: Aldosterone; Animals; Bicarbonates; Colchicine; Cycloheximide; Hydrogen-Ion Concentration; Immunohistochemistry; Kidney Tubules; Kinetics; Mice; Mice, Inbred C57BL; Spironolactone; Vacuolar Proton-Translocating ATPases | 2004 |
Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy.
Topics: Aged; Aldosterone; Animals; beta Catenin; Biomarkers; Cadherins; Cardiomyopathy, Hypertrophic; Cells, Cultured; Collagen; Cyclic AMP; Cytochrome P-450 CYP11B2; Cytoskeletal Proteins; Female; Fibrosis; Gene Expression Profiling; Humans; Hypertrophy; Male; Mice; Mice, Transgenic; Middle Aged; Myocytes, Cardiac; Phenotype; Phosphatidylinositol 3-Kinases; Rats; RNA, Messenger; Signal Transduction; Spironolactone; Trans-Activators; Troponin T | 2004 |
Human endothelium: target for aldosterone.
Topics: Aldosterone; Amiloride; Biological Transport; Body Water; Cell Size; Cells, Cultured; Diuretics; Endothelial Cells; Endothelium, Vascular; Humans; Microscopy, Atomic Force; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Sodium; Sodium Channels; Sodium-Hydrogen Exchangers; Spironolactone; Umbilical Veins | 2004 |
The many targets of aldosterone.
Topics: Aldosterone; Amiloride; Body Water; Cell Size; Endothelial Cells; Endothelium, Vascular; Guanidines; Humans; Hypertension; Ion Transport; Membrane Potentials; Potassium; Receptors, Mineralocorticoid; Sodium; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones | 2004 |
Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells.
Topics: Aldosterone; Canrenoic Acid; Cells, Cultured; Cyproterone Acetate; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Leukocytes, Mononuclear; Lipopolysaccharides; Phytohemagglutinins; Pregnadienes; RNA, Messenger; Spironolactone; Transcription, Genetic | 2004 |
Rats exhibit aldosterone-dependent sodium appetite during 24 h hindlimb unloading.
Topics: Aldosterone; Animals; Appetite; Behavior, Animal; Drinking; Evans Blue; Hindlimb Suspension; Male; Mineralocorticoid Receptor Antagonists; Plasma Volume; Potassium Chloride; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride; Sodium, Dietary; Spironolactone; Time Factors | 2004 |
Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Body Weight; Cardiomegaly; Cardiotonic Agents; Collagen Type I; Collagen Type III; Drug Synergism; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; RNA, Messenger; Spironolactone; Tetrazoles | 2004 |
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.
Topics: Aldosterone; Animals; Biological Transport; Cell Line; Kidney Tubules, Collecting; Mineralocorticoid Receptor Antagonists; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptor Cross-Talk; Receptors, Mineralocorticoid; Serum Albumin, Bovine; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Transcription, Genetic | 2004 |
Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Collagen; Dose-Response Relationship, Drug; Endothelium, Vascular; Eplerenone; Fibrosis; Heart; Hydralazine; Hypertension; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Myocardium; Natriuresis; Organ Size; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Thiobarbituric Acid Reactive Substances; Tunica Media; Vasodilation | 2004 |
Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade.
Topics: Aldosterone; Animals; Blood Glucose; Carboxy-Lyases; Cells, Cultured; Female; Fructose-Bisphosphatase; Gene Expression; Gene Expression Regulation; Gluconeogenesis; Glucose-6-Phosphatase; Hepatocytes; Humans; Insulin; Liver; Mice; Mice, Inbred ICR; Mifepristone; Mineralocorticoid Receptor Antagonists; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Glucocorticoid; Signal Transduction; Spironolactone | 2004 |
Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Cell Line; Enzyme Induction; Eplerenone; Hormone Antagonists; Humans; Lipid Peroxidation; Lipoproteins, LDL; Losartan; Macrophages, Peritoneal; Membrane Proteins; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; Phosphoproteins; Protein Transport; Ramipril; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Superoxides | 2004 |
Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.
Topics: Aldosterone; Angiotensin II; Animals; Apoptosis; Blood Pressure; Cardiomegaly; Cell Size; Eplerenone; Fibrosis; Heart Rate; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Osteopontin; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Spironolactone; Ultrasonography; Ventricular Remodeling | 2004 |
The discovery, isolation and identification of aldosterone: reflections on emerging regulation and function.
Topics: Aldosterone; Angiotensins; Biological Assay; Clinical Trials as Topic; Eplerenone; History, 20th Century; Humans; Proteins; Spironolactone; Technology, Pharmaceutical | 2004 |
The evolution of aldosterone antagonists.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Clinical Trials as Topic; Eplerenone; Gynecomastia; History, 20th Century; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2004 |
Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Cells, Cultured; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Spironolactone | 2004 |
Aldosterone modulates neural vasomotor response in hypertension: role of calcitonin gene-related peptide.
Topics: Adenine; Adenosine Triphosphate; Aldosterone; Animals; Anti-Arrhythmia Agents; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Glyburide; Hypertension; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glucocorticoid; Spironolactone; Vasoconstriction; Vasomotor System | 2004 |
Aldosterone enhances renal calcium reabsorption by two types of channels.
Topics: Absorption; Aldosterone; Animals; Biological Transport; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Canrenone; Cycloheximide; Kidney; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Membranes; Mineralocorticoid Receptor Antagonists; Protein Synthesis Inhibitors; Rabbits; Second Messenger Systems; Sodium; Spironolactone; Time Factors | 2004 |
Co-secretion of aldosterone and cortisol by an adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aldosterone; Diuretics; Female; Histocytochemistry; Humans; Hydrocortisone; Hyperaldosteronism; Hypokalemia; Spironolactone | 2004 |
Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84.
Topics: Aldosterone; Animals; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Kidney; Mice; Phosphorylation; Precipitin Tests; Receptors, Mineralocorticoid; Sirolimus; Spironolactone; src-Family Kinases; Time Factors; Tyrosine | 2004 |
Treatment of heart failure with spironolactone--trial and tribulations.
Topics: Adrenergic beta-Antagonists; Aging; Aldosterone; Drug Therapy, Combination; Glomerular Filtration Rate; Heart Failure; Humans; Hyperkalemia; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone | 2004 |
Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Central Venous Pressure; Chromatography, High Pressure Liquid; Collagen; Heart; Hydroxyproline; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Spironolactone; Tetrazoles; Valine; Valsartan | 2004 |
Mechanisms for aldosterone and spironolactone-induced positive inotropic actions in the rat heart.
Topics: Adenosine Triphosphatases; Aldosterone; Animals; Calcium; Cells, Cultured; Heart; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Myocardial Contraction; Myocytes, Cardiac; Potassium; Rats; Rats, Inbred WKY; Spironolactone; Stimulation, Chemical | 2004 |
The neuroendocrine-immune interface gone awry in aldosteronism.
Topics: Aldosterone; Animals; Central Nervous System; Heart Failure; Humans; Hyperaldosteronism; Kidney; Mineralocorticoid Receptor Antagonists; Myocardial Ischemia; Rats; Spironolactone | 2004 |
Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats.
Topics: Administration, Oral; Aldosterone; Animals; Central Nervous System; Collagen; Epinephrine; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Norepinephrine; Random Allocation; Rats; Rats, Wistar; Spironolactone; Ventricular Function, Left; Ventricular Remodeling | 2004 |
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.
Topics: Aldosterone; Androstadienes; Animals; Blotting, Western; Calcium; Chromones; Enzyme Inhibitors; Eplerenone; Flavonoids; Hydrogen-Ion Concentration; Indoles; Male; Maleimides; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Time Factors; Vasoconstriction; Wortmannin | 2005 |
Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor.
Topics: Aldosterone; Animals; Chlorocebus aethiops; COS Cells; Crystallization; Eplerenone; Kinetics; Ligands; Mineralocorticoid Receptor Antagonists; Models, Molecular; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone | 2004 |
Aldosterone directly stimulates cardiac myocyte hypertrophy.
Topics: Aldosterone; Animals; Animals, Newborn; Cells, Cultured; Culture Media, Serum-Free; Dexamethasone; Extracellular Signal-Regulated MAP Kinases; Glucocorticoids; Hormone Antagonists; Hypertrophy; JNK Mitogen-Activated Protein Kinases; Microscopy, Confocal; Mifepristone; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Protein Kinase C; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone | 2004 |
Aldosterone upregulates connective tissue growth factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes.
Topics: Aldosterone; Animals; Cells, Cultured; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Gene Expression Regulation; Heart Ventricles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Up-Regulation | 2004 |
Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Topics: Aldosterone; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Blood Pressure; Body Weight; Cholesterol; Diuretics; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Organ Size; Spironolactone | 2005 |
ACE inhibitors and mineralocorticoid receptor blockade in patients with congestive heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Models, Cardiovascular; Spironolactone | 2005 |
Hyperparathyroidism and the calcium paradox of aldosteronism.
Topics: Aldosterone; Animals; Bone Density; Bone Resorption; Calcium; Hyperaldosteronism; Hyperparathyroidism; Inflammation; Leukocytes, Mononuclear; Magnesium; Mineralocorticoid Receptor Antagonists; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone | 2005 |
Enhancement of beta-adrenergic cAMP-signaling by the mineralocorticoid receptor.
Topics: Adrenergic beta-Agonists; Aldosterone; Animals; Cell Line; Cyclic AMP; G-Protein-Coupled Receptor Kinase 3; Gene Expression Regulation; GTP-Binding Protein alpha Subunits; Humans; Isoproterenol; Kidney; Peptide Fragments; Protein Serine-Threonine Kinases; Rabbits; Receptor Cross-Talk; Receptors, Adrenergic, beta-2; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transfection | 2005 |
Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adenoviridae; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Aorta; Cell Line, Transformed; Coronary Vessels; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Humans; Hydrocortisone; Losartan; Mammary Tumor Virus, Mouse; Models, Biological; Muscle, Smooth, Vascular; Myocardial Ischemia; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spironolactone; Transcription, Genetic; Transduction, Genetic | 2005 |
The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.
Topics: Aldosterone; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Eplerenone; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Glucocorticoids; Humans; Hydrocortisone; Ligands; Models, Biological; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, Mineralocorticoid; Sequence Homology, Amino Acid; Spironolactone; Transcription, Genetic; Transfection | 2005 |
[Aldosterone and aldosterone antagonists. Eplerenone in cardiac insufficiency after myocardial infarction].
Topics: Aldosterone; Cardiac Output, Low; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Spironolactone | 2005 |
Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective?
Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Blood Pressure; Cardiotonic Agents; Cells, Cultured; Collagen; Coronary Circulation; DNA; Fibroblasts; Heart; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone; Thymidine; Vasoconstrictor Agents; Ventricular Function, Left | 2005 |
Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction.
Topics: Aldosterone; Animals; Cytochrome P-450 CYP11B2; Gene Expression Regulation; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardium; Receptor, Angiotensin, Type 1; Spironolactone; Ventricular Remodeling | 2005 |
Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells.
Topics: Aldosterone; Animals; Binding, Competitive; Cell Death; Cell Hypoxia; Cell Survival; Cytoprotection; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Mineralocorticoid Receptor Antagonists; PC12 Cells; Rats; Receptors, Mineralocorticoid; Spironolactone; Staurosporine; Transfection; Tritium | 2005 |
Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system.
Topics: Aldosterone; Animals; Antihypertensive Agents; Drug Therapy, Combination; Eplerenone; Hypertension; I-kappa B Proteins; Interleukin-1; Interleukin-6; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Spironolactone; Tumor Necrosis Factor-alpha; Vasculitis | 2005 |
Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo.
Topics: Aldosterone; Animals; Apoptosis; Mineralocorticoid Receptor Antagonists; Muscle Cells; Muscle, Skeletal; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Spironolactone | 2005 |
Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes.
Topics: Aldosterone; Animals; Animals, Newborn; Calcium Channels, L-Type; Calcium Channels, T-Type; Corticosterone; Glucocorticoids; Heart Ventricles; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone; Stimulation, Chemical | 2005 |
Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes.
Topics: Aldosterone; Animals; Cell Line; Gene Expression Regulation; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Plasminogen Activator Inhibitor 1; Rats; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Prevention of cardiac remodeling after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Topics: Aldosterone; Angiotensinogen; Animals; Animals, Genetically Modified; Brain; Cell Size; Fibronectins; Fibrosis; Heart Ventricles; Immunohistochemistry; Laminin; Male; Myocardial Infarction; Myocytes, Cardiac; Organ Size; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spironolactone; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2005 |
A role for mineralocorticoid receptor blockade in the prevention of apoptosis.
Topics: Aldosterone; Animals; Apoptosis; Muscle, Skeletal; Rats; Receptors, Mineralocorticoid; Spironolactone | 2005 |
Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity.
Topics: Aldosterone; Animals; Cyclosporine; Immunosuppressive Agents; Kidney Cortex; Male; Mineralocorticoid Receptor Antagonists; Organ Transplantation; Rats; Rats, Wistar; Receptors, Endothelin; Renin-Angiotensin System; RNA, Messenger; Spironolactone | 2005 |
Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aldosterone; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Cells, Cultured; Cycloheximide; Enzyme Activation; Eplerenone; Flavonoids; Genes, Dominant; MAP Kinase Kinase 5; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Synthesis Inhibitors; Rats; Receptors, Mineralocorticoid; Spironolactone; Transfection | 2005 |
Aldosterone increases osteopontin gene expression in rat endothelial cells.
Topics: Aldosterone; Animals; Base Sequence; Cells, Cultured; Cycloheximide; DNA Primers; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Mifepristone; Mineralocorticoid Receptor Antagonists; Osteopontin; Protein Synthesis Inhibitors; Rats; Receptors, Glucocorticoid; RNA, Messenger; Sialoglycoproteins; Spironolactone | 2005 |
Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus.
Topics: Aldosterone; Animals; Aquaporin 2; Cell Membrane; Diabetes Insipidus; Kidney; Kidney Tubules; Lithium; Male; Protein Transport; Rats; Rats, Inbred BB; Rats, Wistar; Spironolactone; Time Factors; Urination; Vasopressins | 2006 |
Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans.
Topics: Adult; Aged; Aldosterone; Biomarkers; Blotting, Western; Case-Control Studies; Diuretics; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Female; Fludrocortisone; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Renin; Serine Endopeptidases; Sodium; Sodium Channels; Sodium Chloride; Sodium, Dietary; Spironolactone | 2005 |
Role of aldosterone in diabetic nephropathy.
Topics: Albuminuria; Aldosterone; Animals; Cells, Cultured; Chemokine CCL2; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Ectodysplasins; Glomerular Mesangium; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Macrophage Migration-Inhibitory Factors; Membrane Proteins; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Inbred OLETF; RNA, Messenger; Spironolactone; Tumor Necrosis Factor Inhibitors | 2005 |
Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.
Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Eplerenone; Heart Failure; Humans; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Spironolactone | 2005 |
Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Binding Sites; Carbenoxolone; Corticosterone; Drug Synergism; In Vitro Techniques; Leydig Cells; Male; Mineralocorticoid Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Testosterone | 2005 |
Eplerenone antagonizes atherosclerosis, but what is the agonist?
Topics: Aldosterone; Animals; Atherosclerosis; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2005 |
N-acetylcysteine attenuates the progression of chronic renal failure.
Topics: Acetylcysteine; Aldosterone; Animals; Antioxidants; Drug Therapy, Combination; Glomerular Filtration Rate; Kidney Failure, Chronic; Lipid Peroxidation; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Rats; Rats, Wistar; Spironolactone | 2005 |
High prevalence of microalbuminuria in chronic heart failure patients.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Albuminuria; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Biomarkers; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Heart Failure; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Natriuretic Peptide, Brain; Netherlands; Peptide Fragments; Prevalence; Renin; Research Design; Spironolactone; Treatment Outcome | 2005 |
Life-threatening hypokalaemia on a low-carbohydrate diet associated with previously undiagnosed primary hyperaldosteronism [corrected].
Topics: Aldosterone; Diabetes Mellitus, Type 2; Diet, Reducing; Dietary Carbohydrates; Humans; Hypoaldosteronism; Hypokalemia; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone; Treatment Outcome | 2005 |
Mechanisms for nongenomic and genomic effects of aldosterone on Na+/H+ exchange in vascular smooth muscle cells.
Topics: Aldosterone; Amiloride; Animals; Cells, Cultured; Eplerenone; Fluorescent Dyes; Genome; Hydrogen-Ion Concentration; Ion Transport; Kinetics; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Sodium-Hydrogen Exchangers; Spironolactone | 2005 |
Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone.
Topics: Aldosterone; Animals; Body Weight; Collagen Type I; Glycoproteins; Heart; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Organ Size; Random Allocation; Rats; Rats, Wistar; Spironolactone; Ventricular Remodeling | 2006 |
Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear.
Topics: Aldosterone; Animals; Antigen-Antibody Complex; Auditory Threshold; Autoimmune Diseases; Body Weight; Cochlea; Disease Models, Animal; Drug Therapy, Combination; Evoked Potentials, Auditory, Brain Stem; Glucocorticoids; Hearing Loss, Sensorineural; Hematocrit; Mice; Mineralocorticoid Receptor Antagonists; Prednisolone; Random Allocation; Receptors, Mineralocorticoid; Spironolactone | 2006 |
Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD.
Topics: Aldosterone; Animals; Antimanic Agents; Diabetes Insipidus, Nephrogenic; Epithelial Sodium Channels; Immunohistochemistry; Kidney Cortex; Kidney Tubules, Collecting; Lithium; Lithium Carbonate; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Sodium; Sodium Channels; Spironolactone | 2006 |
Does aldosterone-to-renin ratio predict the antihypertensive effect of the aldosterone antagonist spironolactone?
Topics: Aldosterone; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Renin-Angiotensin System; Spironolactone | 2005 |
Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium.
Topics: Aldosterone; Amides; Animals; Benzofurans; Cells, Cultured; Eplerenone; Hemodynamics; Hypertrophy; Indoles; Leucine; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Phthalic Acids; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Sodium-Hydrogen Exchangers; Spironolactone; Time Factors | 2006 |
Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Collagen; Ectodysplasins; Fibrosis; Heart; Hypertension; Hypertrophy; Macrophages; Male; Membrane Proteins; Mineralocorticoid Receptor Antagonists; Myocarditis; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Spironolactone; Transcription Factor AP-1; Tumor Necrosis Factors; Vascular Cell Adhesion Molecule-1 | 2005 |
Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.
Topics: Aldosterone; Animals; Aorta; Atherosclerosis; Blood Pressure; Cells, Cultured; Chemokine CCL2; Cholesterol, Dietary; Diet, Atherogenic; Enzyme Activation; Eplerenone; Inflammation; Male; Mice; Muscle, Smooth, Vascular; NADPH Oxidases; Oxidative Stress; Spironolactone; Superoxides; Tetrazoles; Tumor Necrosis Factor-alpha; Valine; Valsartan | 2006 |
Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats.
Topics: Aldosterone; Animals; Body Weight; Echocardiography; Endothelin-1; Heart; Heart Ventricles; Hemodynamics; Male; Mineralocorticoid Receptor Antagonists; Models, Statistical; Myocardium; Neurons; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Size; Perfusion; Rats; Rats, Inbred Dahl; Rats, Wistar; Salts; Sodium Chloride; Spironolactone | 2006 |
Is it time for spironolactone therapy in dialysis patients?
Topics: Aldosterone; Humans; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Renal Dialysis; Spironolactone | 2006 |
Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?
Topics: Aldosterone; Animals; Cardiotonic Agents; Drug Interactions; Eplerenone; Heart; Hemodynamics; In Vitro Techniques; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar; Spironolactone | 2006 |
Protective effect of spironolactone on endothelial cell apoptosis.
Topics: Aldosterone; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cell Survival; Cells, Cultured; Cytochromes c; Cytosol; Dexamethasone; Dihydrotestosterone; Endothelial Cells; Enzyme Activation; Eplerenone; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerases; Receptors, Progesterone; Spironolactone; Time Factors; Umbilical Veins | 2006 |
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiomegaly; Cardiotonic Agents; Coronary Vessels; Corticosterone; Echocardiography; Eplerenone; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Osmolar Concentration; Oxidative Stress; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Renin; RNA, Messenger; Spironolactone; Vasculitis; Ventricular Function; Ventricular Remodeling | 2006 |
Mineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiomegaly; Cardiotonic Agents; Corticosterone; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin; Spironolactone; Ultrasonography | 2006 |
Effects of spironolactone on human blood mononuclear cells: mineralocorticoid receptor independent effects on gene expression and late apoptosis induction.
Topics: Adult; Aldosterone; Apoptosis; Cells, Cultured; Cytokines; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Oligonucleotide Array Sequence Analysis; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone | 2006 |
Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Autoantibodies; Captopril; Diuretics; Drugs, Chinese Herbal; Edema; Furosemide; Humans; Japan; Male; Mice; Nephritis; Oleanolic Acid; Potassium; Random Allocation; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Saponins; Sodium; Spironolactone | 2006 |
Effects of enalapril, tempol, and eplerenone on salt-induced hypertension in dahl salt-sensitive rats.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enalapril; Eplerenone; Epoprostenol; Hypertension; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Inbred Dahl; Sodium Chloride; Spin Labels; Spironolactone; Treatment Outcome | 2006 |
Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinas
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Chemokine CCL2; Coronary Vessels; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibrillar Collagens; Gene Expression; Heart Ventricles; Hypertension; Imidazolidines; Intracellular Signaling Peptides and Proteins; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Peptidyl-Dipeptidase A; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Scavenger Receptors, Class E; Signal Transduction; Sodium Chloride; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
[Use of spironolactone and indapamide in the treatment of low-renin arterial hypertension].
Topics: Adult; Aldosterone; Biomarkers; Blood Pressure; Creatinine; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; Indapamide; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Treatment Outcome | 2006 |
Differential action of steroid hormones on human endothelium.
Topics: Aldosterone; Cell Line; Cell Membrane; Cell Polarity; Dexamethasone; Elasticity; Electric Impedance; Endothelial Cells; Glucocorticoids; Hormone Antagonists; Humans; Microscopy, Atomic Force; Mifepristone; Mineralocorticoid Receptor Antagonists; Spironolactone | 2006 |
Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Animals; Collagen Type IV; Connective Tissue Growth Factor; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Male; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Proteinuria; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone | 2006 |
The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.
Topics: Actins; Aldosterone; Animals; Blotting, Western; Cytochrome P-450 CYP11B2; Drug Therapy, Combination; Eplerenone; Fibrosis; Heart Failure; Heart Ventricles; Hypertension; Immunohistochemistry; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Proliferating Cell Nuclear Antigen; Protein Precursors; Random Allocation; Rats; Rats, Inbred WKY; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension.
Topics: Acute Disease; Aldosterone; Angiotensin II; Animals; Aquaporin 2; Blood Pressure; Drinking; Hypertension, Renal; Male; Membrane Transport Proteins; Mineralocorticoid Receptor Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Spironolactone; Thirst; Urea; Urea Transporters; Vasoconstrictor Agents; Water | 2006 |
Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.
Topics: Aldosterone; Animals; Drinking; Epithelial Sodium Channels; Hormone Antagonists; Immunoblotting; Immunohistochemistry; Infusions, Intravenous; Kidney Tubules, Collecting; Male; Microscopy, Confocal; Mifepristone; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Spironolactone | 2007 |
Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Eplerenone; Heart; Hypertrophy; Male; Mice; Mice, Knockout; Myocardium; Spironolactone; Ventricular Remodeling | 2006 |
Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Cell Proliferation; Disease Models, Animal; Diuretics; Fibrosis; Glomerulonephritis, Membranoproliferative; Ki-67 Antigen; Kidney; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Spironolactone; Tetrazoles; Transforming Growth Factor beta; Valine; Valsartan | 2006 |
Mineralocorticoid-receptor blockade, hypertension and heart failure.
Topics: Aldosterone; Clinical Trials as Topic; Eplerenone; Heart Failure; Hormone Antagonists; Humans; Hyperkalemia; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone | 2005 |
Adding spironolactone to conventional antihypertensives reduces albuminuria in patients with diabetic nephropathy.
Topics: Adult; Aldosterone; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Humans; Hypertension, Renal; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Treatment Outcome | 2006 |
Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats.
Topics: Actins; Aldosterone; Animals; Cytochrome P-450 CYP11B2; Hydroxyproline; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium-Hydrogen Exchangers; Spironolactone; Swine | 2006 |
Rapid effects of aldosterone on clonal human vascular smooth muscle cells.
Topics: Aldosterone; Aorta, Thoracic; Cell Line; Clone Cells; Eplerenone; Estradiol; Humans; Hydrocortisone; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Spironolactone; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Eplerenone relieves spironolactone-induced painful gynaecomastia in a patient with primary aldosteronism.
Topics: Administration, Oral; Aldosterone; Clinical Trials as Topic; Eplerenone; Gynecomastia; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Sex Factors; Spironolactone | 2007 |
Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure: Beneficial effects of mineralocorticoid receptor blocker.
Topics: Aldosterone; Angiotensin II; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP11B2; Diastole; Eplerenone; Heart Failure; Heart Ventricles; Male; Mass Spectrometry; Mineralocorticoid Receptor Antagonists; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Steroids; Stroke Volume; Ventricular Function, Left | 2007 |
The effect of aldosterone blockade in patients with Alport syndrome.
Topics: Adolescent; Adult; Aldosterone; Child; Female; Glomerular Filtration Rate; Humans; Male; Mineralocorticoid Receptor Antagonists; Nephritis, Hereditary; Proteinuria; Spironolactone | 2006 |
Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors.
Topics: Adipocytes; Adrenal Glands; Aldosterone; Animals; Cyclic N-Oxides; Disease Models, Animal; Eplerenone; Immediate-Early Proteins; Kidney Failure, Chronic; Male; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Obesity; Podocytes; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proteinuria; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; RNA, Messenger; Spin Labels; Spironolactone | 2006 |
Aldosterone antagonism in an inflammatory state: evidence for myocardial protection.
Topics: Aldosterone; Animals; Cardiotonic Agents; Chagas Cardiomyopathy; Collagen; Cricetinae; Disease Models, Animal; Echocardiography, Doppler, Color; Female; Mesocricetus; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Trypanosoma cruzi; Ventricular Remodeling | 2006 |
Primary hyperaldosteronism in a patient with end-stage renal disease.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Follow-Up Studies; Fosinopril; Humans; Hyperaldosteronism; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renal Dialysis; Renin; Spironolactone | 2007 |
Effects of eplerenone and salt intake on left ventricular remodeling after myocardial infarction in rats.
Topics: Aldosterone; Animals; Cardiomegaly; Diet, Sodium-Restricted; Echocardiography; Eplerenone; Fibrosis; Food-Drug Interactions; Heart; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Rats; Rats, Wistar; Sodium Chloride; Spironolactone; Ventricular Remodeling | 2006 |
[MEN type I presenting hypokalemia and hypertension, complicated with acromegaly, adrenal cortical tumor and rectal carcinoid tumor].
Topics: Acromegaly; Adrenalectomy; Adrenocortical Adenoma; Aged; Aldosterone; Carcinoid Tumor; Female; Growth Hormone-Secreting Pituitary Adenoma; Humans; Hypertension; Hypokalemia; Mineralocorticoid Receptor Antagonists; Multiple Endocrine Neoplasia Type 1; Rectal Neoplasms; Spironolactone | 2006 |
Transactivation of the IGF-1R by aldosterone.
Topics: Aldosterone; Animals; Cell Line; Dactinomycin; Epithelial Cells; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Kidney; Mifepristone; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptor, Insulin; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transcriptional Activation; Xenopus laevis; Xenopus Proteins | 2007 |
Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.
Topics: Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Cells, Cultured; Cyclic N-Oxides; Enzyme Activation; Eplerenone; Hydralazine; Immediate-Early Proteins; Infusion Pumps; Kidney; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Nephrectomy; Oxidative Stress; Podocytes; Protein Serine-Threonine Kinases; Proteinuria; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spin Labels; Spironolactone; Time Factors; Up-Regulation | 2007 |
Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Echocardiography; Injections, Subcutaneous; Myocardium; Organ Size; Random Allocation; Rats; Rats, Inbred Strains; Spironolactone; Ventricular Function, Left; Weight Loss | 2006 |
Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Vessels; Cyclic N-Oxides; Eplerenone; Gene Expression Regulation; Hypertension; Inflammation Mediators; Male; Models, Biological; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Spin Labels; Spironolactone; Tetrazoles | 2007 |
Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.
Topics: Aldosterone; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cell Line; Cell Proliferation; Enzyme Activation; Eplerenone; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Mesangial Cells; Mice; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinases; Mitosis; Phosphorylation; Signal Transduction; Smad6 Protein; Spironolactone; Transforming Growth Factor beta | 2007 |
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.
Topics: Aldosterone; Analysis of Variance; Blotting, Northern; Cells, Cultured; Chromatin Immunoprecipitation; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; Glucosephosphate Dehydrogenase; Humans; Immunoblotting; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Spironolactone | 2007 |
A German family with glucocorticoid-remediable aldosteronism.
Topics: Adolescent; Aldosterone; Algorithms; Blood Pressure; Dexamethasone; Eplerenone; Female; Germany; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Molecular Sequence Data; Pedigree; Sodium; Spironolactone; Steroid 11-beta-Hydroxylase | 2007 |
Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Aorta; Blood Pressure; Blood Pressure Determination; Cells, Cultured; Connective Tissue Growth Factor; Eplerenone; Hypertension; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spironolactone; Up-Regulation | 2007 |
Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone.
Topics: Aldosterone; Cell Enlargement; Cell Line; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Elasticity; Endothelial Cells; Eplerenone; Humans; In Vitro Techniques; Microscopy, Atomic Force; Mineralocorticoid Receptor Antagonists; Spironolactone | 2007 |
[Effects of aldosterone on synthesis of fibronectin and expression of transforming growth factor-beta1 mRNA in cultured rat mesangial cells].
Topics: Aldosterone; Animals; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fibronectins; Gene Expression Regulation; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Transforming Growth Factor beta1 | 2007 |
Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; Drug Synergism; Eplerenone; Hypertension; Indoles; Kidney; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Spironolactone; Superoxide Dismutase; Transforming Growth Factor beta | 2007 |
Complementary and incremental mortality risk prediction by cortisol and aldosterone in chronic heart failure.
Topics: Aged; Aged, 80 and over; Aldosterone; C-Reactive Protein; Cause of Death; Cohort Studies; Comorbidity; Discriminant Analysis; Female; Follow-Up Studies; Heart Failure; Humans; Hydrocortisone; Kaplan-Meier Estimate; Male; Middle Aged; Mortality; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Proportional Hazards Models; Prospective Studies; Receptors, Mineralocorticoid; Risk; Spironolactone | 2007 |
Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.
Topics: Aldosterone; Animals; Blotting, Western; Catalase; Glutathione Peroxidase; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Reperfusion Injury; RNA; Spironolactone; Superoxide Dismutase; Vasoconstriction | 2007 |
Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis.
Topics: Adipocytes, White; Adipogenesis; Adipose Tissue, White; Aldosterone; Animals; Cell Differentiation; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Insulin; Male; Metabolic Syndrome; Mice; Obesity; Phenotype; PPAR gamma; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; RNA, Small Interfering; Spironolactone; Swiss 3T3 Cells; Transcription, Genetic | 2007 |
Aldosterone up-regulates production of plasminogen activator inhibitor-1 by renal mesangial cells.
Topics: Acetylcysteine; Aldosterone; Angiotensin II; Animals; Antibodies; Cells, Cultured; Dose-Response Relationship, Drug; Mesangial Cells; Neutralization Tests; Plasminogen Activator Inhibitor 1; Rats; Reactive Oxygen Species; RNA, Messenger; Spironolactone; Time Factors; Transforming Growth Factor beta1; Up-Regulation | 2007 |
Aldosterone antagonism fails to attenuate age-associated left ventricular fibrosis.
Topics: Aging; Aldosterone; Animals; Atrial Natriuretic Factor; Collagen; Collagen Type III; Female; Fibrosis; Gene Expression; Heart Ventricles; Mineralocorticoid Receptor Antagonists; Myocardium; Myosin Heavy Chains; Rats; Rats, Inbred F344; RNA, Messenger; Spironolactone; Tissue Distribution; Ventricular Myosins | 2007 |
Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation.
Topics: Aldosterone; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Body Weight; Cytokines; Disease Models, Animal; Eplerenone; Female; Fibroblasts; Fibrosis; Hypertension; Immunohistochemistry; In Situ Hybridization; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Macrophages; Mice; Mice, Inbred BALB C; Mineralocorticoid Receptor Antagonists; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone; Tenascin; Up-Regulation; Vasoconstrictor Agents | 2007 |
Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatment.
Topics: Adrenalectomy; Aldosterone; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Italy; Kidney Diseases, Cystic; Mineralocorticoid Receptor Antagonists; Prevalence; Prospective Studies; Spironolactone | 2007 |
Polycystic ovary syndrome: implications of corticotropin in the regulation of blood pressure, aldosterone, and androgen secretion.
Topics: Adrenocorticotropic Hormone; Aldosterone; Biomarkers; Blood Pressure; Female; Humans; Hypertension; Polycystic Ovary Syndrome; Risk Factors; Spironolactone | 2007 |
Curriculum in cardiology: Integrated diagnosis and management of diastolic heart failure (Am Heart J 2007;153:189-200).
Topics: Adult; Aldosterone; Diastole; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2007 |
Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor.
Topics: Aldosterone; Animals; Cell Culture Techniques; Connective Tissue Growth Factor; Dexamethasone; Glomerular Mesangium; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kinetics; Protein Transport; Rats; Receptors, Glucocorticoid; RNA, Messenger; Spironolactone | 2007 |
Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone.
Topics: Aldosterone; Animals; Coronary Vessels; Disease Models, Animal; Feces; Fibrosis; Homeostasis; Hyperaldosteronism; Liver; Male; Metabolic Diseases; Metallothionein; Mineralocorticoid Receptor Antagonists; Muscle, Skeletal; Myocardium; Nephrectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Superoxide Dismutase; Time Factors; Zinc | 2007 |
Tailored hormonal therapy in secretory adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Antifungal Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Captopril; Cisplatin; Diarrhea; Doxorubicin; Etoposide; Female; Heart Failure; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypokalemia; Ketoconazole; Mineralocorticoid Receptor Antagonists; Mitotane; Neoplasm Recurrence, Local; Potassium; Rhabdomyolysis; Spironolactone; Tachycardia | 2007 |
Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence.
Topics: Aldosterone; Angiotensin II; Animals; Aorta, Thoracic; beta-Galactosidase; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Male; Muscle, Smooth, Vascular; Oxidative Stress; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Renin-Angiotensin System; RNA, Small Interfering; Spironolactone; Tetrazoles; Tumor Suppressor Protein p53; Valine; Valsartan | 2007 |
Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Blood Pressure; Cytochrome P-450 CYP1A1; Hematocrit; Hypertension, Malignant; Kidney; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Proteinuria; Rats; Renin; Sodium; Spironolactone | 2007 |
Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner.
Topics: Aldosterone; Animals; Cells, Cultured; Collagen Type I; Elastin; Fibroblasts; Gene Expression Regulation; Hormone Antagonists; Humans; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardium; Phosphorylation; Receptor, IGF Type 1; Receptors, Mineralocorticoid; Spironolactone; Tropoelastin; Tyrosine | 2007 |
Unexpected therapeutic response to spironolactone: a prospective debate on aldosterone and potassium ion in hypertension.
Topics: Aldosterone; Dose-Response Relationship, Drug; Humans; Hypertension; Potassium; Renin-Angiotensin System; Sodium, Dietary; Spironolactone | 2007 |
Acute aldosterone infusion enhances thrombosis development in normotensive rats.
Topics: Aldosterone; Animals; Blood Coagulation; Blood Pressure; Carboxypeptidase B2; Disease Models, Animal; Eplerenone; Infusions, Intravenous; Male; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone; Thromboplastin; Thrombosis; Tissue Plasminogen Activator | 2007 |
Avoiding vicious circles: mineralocorticoid receptor antagonism prevents vascular oxidative stress early after myocardial infarction.
Topics: Aldosterone; Angiotensin II; Animals; Endothelium, Vascular; Eplerenone; Humans; Mice; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Oxidative Stress; Rats; Signal Transduction; Spironolactone | 2007 |
Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress.
Topics: Aldosterone; Animals; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Eplerenone; Hypertension; Kidney Diseases; Male; Metabolic Syndrome; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Mutant Strains; Receptors, Cell Surface; Receptors, Leptin; Receptors, Mineralocorticoid; Renin; Sodium Chloride, Dietary; Spin Labels; Spironolactone | 2007 |
A possible association between primary aldosteronism and a lower beta-cell function.
Topics: Aged; Aldosterone; Blood Glucose; C-Peptide; Case-Control Studies; Cholesterol; Female; Humans; Hyperaldosteronism; Hypertension; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone; Triglycerides | 2007 |
Aldosterone and amiloride alter ENaC abundance in vascular endothelium.
Topics: Aldosterone; Amiloride; Blotting, Western; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Diuretics; Endothelial Cells; Epithelial Sodium Channels; Fluorescent Antibody Technique; Humans; Microscopy, Atomic Force; Spironolactone; Umbilical Veins | 2008 |
Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Antihypertensive Agents; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Prospective Studies; Renin; Spironolactone; Time | 2007 |
Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Endothelium, Vascular; Eplerenone; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Spironolactone; Tetrazoles | 2007 |
Is aldosterone a pro-arrhythmic hormone?
Topics: Aldosterone; Arrhythmias, Cardiac; Coronary Artery Disease; Humans; Peptide Fragments; Procollagen; Spironolactone | 2007 |
Lessons in the diagnosis and management of Conn's syndrome.
Topics: Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Amiloride; Amlodipine; Calcium Channel Blockers; Humans; Hydrocortisone; Male; Middle Aged; Spironolactone | 2007 |
[Effect of aldosterone on the expression of plasminogen activator inhibitor-1 in renal mesangial cells: experiment with rat renal mesangial cells].
Topics: Aldosterone; Animals; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression; Mesangial Cells; Microscopy, Confocal; Plasminogen Activator Inhibitor 1; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Time Factors; Transforming Growth Factor beta1 | 2007 |
Aldosterone induces superoxide generation via Rac1 activation in endothelial cells.
Topics: Acetophenones; Aldosterone; Animals; Aorta, Thoracic; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Eplerenone; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone; Superoxides | 2008 |
Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.
Topics: Aldosterone; Amiloride; Animals; Cell Line; Cytochalasin B; Dactinomycin; Gene Expression Regulation; Genome; Guanidines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Immunoblotting; Kidney Tubules, Proximal; Methacrylates; Mifepristone; Oxidative Stress; Protein Isoforms; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; RNA, Messenger; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones | 2008 |
Cardiovascular outcomes in patients with primary aldosteronism after treatment.
Topics: Adrenalectomy; Adult; Aged; Aldosterone; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prospective Studies; Spironolactone; Time Factors | 2008 |
Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation.
Topics: Acetophenones; Aldosterone; Animals; Benzophenanthridines; Benzopyrans; Biological Transport; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epithelial Sodium Channels; Immunoprecipitation; Kidney Cortex; Kidney Tubules, Collecting; Mice; Microscopy, Confocal; Protein Kinase C; RNA Interference; Spironolactone | 2008 |
Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability.
Topics: Acetylcholine; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Atherosclerosis; Biological Availability; Blood Pressure; Cholesterol; Enalapril; Eplerenone; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Rabbits; Reactive Oxygen Species; Spironolactone | 2008 |
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".
Topics: Aldosterone; Amiloride; Antihypertensive Agents; Bendroflumethiazide; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Losartan; Sodium Chloride Symporter Inhibitors; Spironolactone | 2008 |
Effect of aldosterone on isolated human penile corpus cavernosum tissue.
Topics: Adult; Aged; Aldosterone; Humans; In Vitro Techniques; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Penile Erection; Penis; Phentolamine; Spironolactone | 2008 |
Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.
Topics: Aldosterone; Animals; Clodronic Acid; Collagen; Cytokines; Eplerenone; Factor XIIIa; Heart Failure; Humans; Male; Mineralocorticoid Receptor Antagonists; Monocytes; Myocardial Infarction; Myocarditis; Myocardium; Neovascularization, Physiologic; Rats; Rats, Wistar; RNA, Messenger; Spironolactone; Ventricular Function, Left; Wound Healing | 2008 |
Translational research goes both ways: lessons from clinical studies.
Topics: Aldosterone; Amino Acid Sequence; Antihypertensive Agents; Biomedical Research; Clinical Trials as Topic; Corticosterone; Dose-Response Relationship, Drug; Eplerenone; Genetic Predisposition to Disease; Heart Failure; Humans; Hypertension; Receptors, Mineralocorticoid; Spironolactone | 2008 |
Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Dimerization; Eplerenone; Male; Mesentery; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Receptor, Angiotensin, Type 1; Spironolactone; Tetrazoles; Transglutaminases; Valine; Valsartan; Vasoconstriction; Vasodilation | 2008 |
Genomic regulation of intestinal amino acid transporters by aldosterone.
Topics: Aldosterone; Amino Acid Transport Systems; Animals; Body Weight; Epithelial Cells; Gene Expression Regulation; Genome; Intestinal Mucosa; Intestines; Jejunum; Kidney; Male; Osmolar Concentration; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sodium Chloride, Dietary; Spironolactone | 2008 |
Sub-chronic stimulation of glucocorticoid receptor impairs and mineralocorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic beta-cells.
Topics: Aldosterone; Animals; Calcium; Corticosterone; Cytosol; Dose-Response Relationship, Drug; Female; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mifepristone; Pertussis Toxin; Pregnancy; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 2008 |
Aldosterone induces mesangial cell apoptosis both in vivo and in vitro.
Topics: Aldosterone; Animals; Antioxidants; Apoptosis; bcl-Associated Death Protein; Blood Pressure; Creatinine; Cytochromes c; Eplerenone; Free Radical Scavengers; Humans; In Situ Nick-End Labeling; Kidney Glomerulus; Male; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Spironolactone | 2008 |
Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.
Topics: Aldosterone; Aorta; Cell Adhesion; Cell Line; Coronary Vessels; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; RNA, Messenger; RNA, Small Interfering; Spironolactone; Transcription, Genetic | 2008 |
Proteins interact with the cytosolic mineralocorticoid receptor depending on the ligand.
Topics: 14-3-3 Proteins; Aldosterone; Cell Line; Chromatography, Affinity; Cytosol; Electrophoresis; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Methylmalonyl-CoA Decarboxylase; Mineralocorticoid Receptor Antagonists; Molecular Chaperones; Protein Binding; Proteomics; Receptors, Mineralocorticoid; Recombinant Fusion Proteins; Spironolactone; Transfection | 2008 |
Aldosterone-induced changes in the cardiac L-type Ca(2+) current can be prevented by antioxidants in vitro and are absent in rats on low salt diet.
Topics: Acetylcysteine; Action Potentials; Aldosterone; Animals; Antioxidants; Calcium Channels, L-Type; Corticosterone; Diet, Sodium-Restricted; Electrocardiography; Heart Rate; Heart Ventricles; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Oxidation-Reduction; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone; Time Factors | 2008 |
Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Signaling; Cardiomyopathies; Cricetinae; Eplerenone; Heart Failure; Mineralocorticoid Receptor Antagonists; Models, Cardiovascular; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Renin-Angiotensin System; Spironolactone | 2008 |
Cardiac benefits of mineralocorticoid receptor inhibition in renal failure.
Topics: Aldosterone; Animals; Cohort Studies; Disease Models, Animal; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Mice; Mineralocorticoid Receptor Antagonists; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Spironolactone; Treatment Outcome | 2008 |
Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder.
Topics: Aldosterone; Animals; Blood Pressure Determination; Disease Models, Animal; Echocardiography, Doppler; Eplerenone; Heart Failure, Diastolic; Heart Function Tests; Male; Metabolic Syndrome; Random Allocation; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Reference Values; Sensitivity and Specificity; Sodium Chloride; Spironolactone; Urinalysis; Ventricular Dysfunction, Left | 2008 |
Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion.
Topics: Aldosterone; Animals; Barium; Colon; Female; Gene Deletion; Gene Expression Regulation; Immunohistochemistry; Ionomycin; Ionophores; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; Mice; Mineralocorticoid Receptor Antagonists; Peptides; Polymerase Chain Reaction; Potassium; Spironolactone; Up-Regulation | 2008 |
Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Cells, Cultured; Down-Regulation; Eplerenone; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Time Factors | 2008 |
Genomic and nongenomic dose-dependent biphasic effect of aldosterone on Na+/H+ exchanger in proximal S3 segment: role of cytosolic calcium.
Topics: Aldosterone; Ammonium Chloride; Animals; Calcium; Calcium Signaling; Cycloheximide; Cytosol; Dactinomycin; Gene Expression; Guanidines; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Male; Methacrylates; Mifepristone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones | 2008 |
[Role of antialdosteronics in the treatment of refractory hypertension].
Topics: Aldosterone; Clinical Trials as Topic; Diuretics; Drug Resistance; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spain; Spironolactone; Time Factors | 2008 |
Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells.
Topics: Aldosterone; Amides; Animals; Cell Transdifferentiation; Collagen; Eplerenone; Gene Expression Regulation; Hypertrophy; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Muscle Development; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; rho-Associated Kinases; Signal Transduction; Spironolactone | 2008 |
Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Collagen Type I; Fibrosis; Gene Expression Regulation; Hydroxyproline; Hypertension; Kidney; Male; Organ Size; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Spironolactone; Systole | 2008 |
Effects of drospirenone on cardiovascular markers in human aortic endothelial cells.
Topics: Adolescent; Aldosterone; Androstenes; Aorta; Biomarkers; Cardiotonic Agents; Cardiovascular System; Cells, Cultured; Chemokine CCL2; Coronary Vessels; E-Selectin; Endothelial Cells; Female; Humans; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Progesterone; Progesterone Congeners; Promegestone; Spironolactone | 2009 |
Effect of single treatment with the antihypertensive drug eplerenone on hormone levels and anxiety-like behaviour in rats.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Corticosterone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eplerenone; Hormones; Male; Maze Learning; Rats; Rats, Wistar; Renin; Spironolactone | 2008 |
Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology.
Topics: Aldosterone; Angiogenesis Inhibitors; Angiotensin II Type 1 Receptor Blockers; Animals; Cattle; Cells, Cultured; Cytokines; Endothelial Cells; Eye Proteins; Glucosephosphate Dehydrogenase; Leukostasis; Mineralocorticoid Receptor Antagonists; NADPH Oxidase 4; NADPH Oxidases; Neovascularization, Pathologic; Oxidative Stress; Oxygen; Pericytes; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Retinal Vasculitis; Sodium Chloride; Spironolactone; Tetrazoles; Valine; Valsartan; Vascular Endothelial Growth Factor A | 2009 |
Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats.
Topics: Aldosterone; Amiloride; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cerebrospinal Fluid; Diuretics; Dose-Response Relationship, Drug; Eplerenone; Heart Rate; Hypertension; Injections, Intraventricular; Losartan; Ouabain; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Sodium; Spironolactone | 2009 |
Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia.
Topics: Aldosterone; Animals; Creatinine; Electrolytes; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Spironolactone; Urea; Uremia | 2008 |
Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation.
Topics: Aldosterone; Animals; Aorta, Thoracic; Apoptosis; bcl-Associated Death Protein; Blood Pressure; Cytochromes c; Disease Models, Animal; Hypertension; Lipid Metabolism; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin; Renin-Angiotensin System; Spironolactone | 2009 |
The Janus effect: two faces of aldosterone.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Humans; Kidney Diseases; NG-Nitroarginine Methyl Ester; Rats; Sodium; Spironolactone | 2009 |
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Topics: Aldosterone; Animals; Blood Pressure; Corticosterone; Cytochrome P-450 CYP11B2; Disease Models, Animal; Enzyme Inhibitors; Heart Rate; Hippocampus; Hypertension; Hypothalamus; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Sodium; Sodium Chloride, Dietary; Spironolactone; Steroid Hydroxylases; Time Factors | 2009 |
Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.
Topics: Acetophenones; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Blood Pressure; Hypertension; Kidney; Losartan; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Protein Subunits; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Spironolactone; Superoxides | 2008 |
Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules.
Topics: Actins; Aldosterone; Butadienes; Cadherins; Cell Transdifferentiation; Cells, Cultured; Collagen; Enzyme Activation; Epithelial Cells; Fibrosis; Humans; Kidney Tubules, Proximal; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Time Factors | 2008 |
Aldosterone regulates cellular turnover and mitogen-activated protein kinase family expression in the neonatal rat kidney.
Topics: Aldosterone; Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Kidney; MAP Kinase Signaling System; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Spironolactone | 2009 |
Direct action of aldosterone on bicarbonate reabsorption in in vivo cortical proximal tubule.
Topics: Aldosterone; Animals; Bicarbonates; Cycloheximide; Dactinomycin; Hydrogen-Ion Concentration; Kidney Cortex; Kidney Tubules, Proximal; Male; Microelectrodes; Mineralocorticoid Receptor Antagonists; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Spironolactone | 2009 |
Aldosterone blockade by Spironolactone improves the hypertensive vascular hypertrophy and remodeling in angiotensin II overproducing transgenic mice.
Topics: Aldosterone; Angiotensin II; Animals; Female; Hyperplasia; Hypertension; Hypertrophy; Male; Mice; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Osteopontin; Renin-Angiotensin System; Spironolactone; Tunica Intima | 2009 |
Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism.
Topics: Aldehydes; Aldosterone; Amlodipine; Animals; Calcium; Calcium Channel Blockers; Chronic Disease; Disease Models, Animal; Glutathione Peroxidase; Homeostasis; Hydrogen Peroxide; Hyperaldosteronism; Male; Metallothionein; Mineralocorticoid Receptor Antagonists; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Superoxide Dismutase; Tyrosine; Zinc | 2009 |
Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.
Topics: Aldosterone; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cells, Cultured; Drug Interactions; Eplerenone; Fenofibrate; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Mineralocorticoid Receptor Antagonists; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; PPAR alpha; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Spironolactone | 2009 |
Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Base Sequence; Cell Line; DNA Primers; Doxorubicin; Gene Expression Regulation, Enzymologic; Glucuronidase; Kidney Diseases; Kidney Glomerulus; Male; Podocytes; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Spironolactone | 2009 |
The regulatory role of glucocorticoid and mineralocorticoid receptors in pulsatile urea excretion of the gulf toadfish, Opsanus beta.
Topics: Aldosterone; Animals; Batrachoidiformes; Biological Transport; Hydrocortisone; Nitrogen; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Stress, Physiological; Urea | 2009 |
Aldosterone in clinical nephrology--old hormone, new questions.
Topics: Aldosterone; Eplerenone; Humans; Hypertension; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Nephrology; Spironolactone | 2009 |
Electrophysiological responses of sympathetic preganglionic neurons to ANG II and aldosterone.
Topics: Aldosterone; Anesthetics, Local; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Fibers, Preganglionic; Benzimidazoles; Biphenyl Compounds; Eplerenone; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Spironolactone; Synaptic Transmission; Tetrazoles; Tetrodotoxin; Time Factors | 2009 |
Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.
Topics: Aldosterone; Androstadienes; Animals; Apoptosis; Cell Line; Cell Survival; Cells, Cultured; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Podocytes; Pyridines; Rats; Spironolactone; Wortmannin | 2009 |
Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha.
Topics: Adult; Aldosterone; Cross-Sectional Studies; Female; Humans; Hyperaldosteronism; Hypertension; Interleukin-10; Male; Middle Aged; Renin; Renin-Angiotensin System; Spironolactone; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cerebral Arteries; Chemokine CCL2; Eplerenone; Female; Gene Expression; Hypertension, Renal; Immunohistochemistry; Intracranial Aneurysm; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Ovariectomy; Oxidative Stress; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Tyrosine | 2009 |
Adrenalectomy prevents renal ischemia-reperfusion injury.
Topics: Adrenalectomy; Aldosterone; Animals; Kidney; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Receptor, Endothelin A; Reperfusion Injury; rho-Associated Kinases; Spironolactone | 2009 |
Update in primary aldosteronism.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Amiloride; Antihypertensive Agents; Chromosomes, Human, Pair 7; Cytochrome P-450 CYP11B2; Diagnosis, Differential; Drug Administration Schedule; Eplerenone; Genetic Linkage; Glucocorticoids; Humans; Hyperaldosteronism; Hypertension; Lod Score; Mineralocorticoid Receptor Antagonists; Spironolactone | 2009 |
Dietary salt restriction activates mineralocorticoid receptor signaling in volume-overloaded heart failure.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Body Weight; Cell Size; Contraindications; Diet, Sodium-Restricted; Endomyocardial Fibrosis; Heart; Heart Failure; Hemodynamics; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transforming Growth Factor beta; Tyrosine; Ventricular Remodeling | 2009 |
Nitric oxide-mediated dilation of arterioles to intraluminal administration of aldosterone.
Topics: Acetophenones; Acetylcholine; Aldosterone; Animals; Arterioles; Cerebrum; Cyclic N-Oxides; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Male; Mesentery; Muscle, Smooth, Vascular; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Spin Labels; Spironolactone; Superoxides; Vasoconstriction; Vasodilation | 2009 |
Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.
Topics: Acetophenones; Active Transport, Cell Nucleus; Aldosterone; Animals; Benzopyrans; Cell Line; Cell Proliferation; Cytoplasm; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney Cortex; Kidney Tubules, Collecting; Mice; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Protein Binding; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; TRPP Cation Channels; Tyrphostins | 2010 |
The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.
Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hypertension; Infusion Pumps, Implantable; Infusions, Subcutaneous; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Spironolactone; Time Factors | 2009 |
Eplerenone, a selective mineralocorticoid receptor blocker, exerts anxiolytic effects accompanied by changes in stress hormone release.
Topics: Adrenal Cortex; Aldosterone; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Eplerenone; Exploratory Behavior; Hippocampus; Male; Mineralocorticoid Receptor Antagonists; Neuronal Plasticity; Oxytocin; Pituitary Gland, Posterior; Random Allocation; Rats; Rats, Wistar; Spironolactone; Stress, Psychological; Vasopressins | 2010 |
Differential effects of 17beta-estradiol and of synthetic progestins on aldosterone-salt-induced kidney disease.
Topics: Aldosterone; Androstenes; Animals; Blood Pressure; Epithelial Sodium Channels; Estradiol; Female; Hypertrophy; Kidney; Kidney Diseases; Medroxyprogesterone Acetate; Oxidative Stress; Progesterone Congeners; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Cytoplasmic and Nuclear; Sodium Chloride; Spironolactone | 2009 |
Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction.
Topics: Aldosterone; Angina, Unstable; Animals; Apoptosis; Dexamethasone; Glucocorticoids; Hormone Antagonists; Hydrocortisone; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone | 2009 |
Clinical effects of eplerenone, a selective aldosterone blocker, in Japanese patients with essential hypertension.
Topics: Aged; Albuminuria; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asian People; Calcium Channel Blockers; Drug Therapy, Combination; Eplerenone; Female; Humans; Hypertension; Japan; Male; Metabolic Syndrome; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone; Treatment Outcome; Triglycerides | 2010 |
Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: the impact of oxidative stress.
Topics: Adrenocorticotropic Hormone; Aldosterone; Biomarkers; Chronic Disease; Diuretics; Follow-Up Studies; Heart Failure; Hospitalization; Humans; Hydrocortisone; Kaplan-Meier Estimate; Linear Models; Lipoproteins, LDL; Mineralocorticoid Receptor Antagonists; Natriuretic Peptide, Brain; Oxidative Stress; Predictive Value of Tests; Proportional Hazards Models; Risk Assessment; Risk Factors; Spironolactone; Time Factors; Treatment Outcome | 2009 |
[Effects of perindopril and spirolactone on plasma aldosterone and left atrial remodeling in a canine model of atrial fibrillation].
Topics: Aldosterone; Animals; Atrial Fibrillation; Atrial Function; Disease Models, Animal; Dogs; Male; Mineralocorticoid Receptor Antagonists; Perindopril; Spironolactone | 2009 |
Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Chlorocebus aethiops; COS Cells; Disease Models, Animal; E1A-Associated p300 Protein; GATA4 Transcription Factor; Hypertrophy; Mice; Myocytes, Cardiac; NIH 3T3 Cells; Phenylephrine; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transfection | 2010 |
Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Blood Pressure; Eplerenone; Fibrosis; Heart; Immunohistochemistry; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Myocardium; Oxidative Stress; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Sodium Chloride; Spironolactone | 2010 |
Spironolactone for all hypertensive patients?
Topics: Aldosterone; Diuretics; Drug Therapy, Combination; Humans; Hyperaldosteronism; Hypertension; Practice Patterns, Physicians'; Spironolactone | 2010 |
Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.
Topics: Adult; Aged; Aldosterone; Angiotensinogen; Black or African American; Cohort Studies; Diuretics; Female; Genotype; Heart Failure; Humans; Hyperkalemia; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Receptors, Mineralocorticoid; Spironolactone; Statistics as Topic; White People | 2010 |
Aldosterone stimulates the proliferation of uterine leiomyoma cells.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Division; Cell Line, Tumor; Female; Gene Expression; Leiomyoma; Rats; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Spironolactone; Up-Regulation; Uterine Neoplasms | 2010 |
Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats.
Topics: Aldosterone; Animals; Eplerenone; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Nephrectomy; Prorenin Receptor; Rats; Rats, Transgenic; Receptors, Cell Surface; Sodium Chloride, Dietary; Spironolactone | 2010 |
Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists.
Topics: Aldosterone; Animals; Cells, Cultured; Chromones; Chromosomes; Comet Assay; Cytoprotection; Dihydropyridines; DNA Breaks; DNA Damage; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hormone Antagonists; Kidney; Micronucleus Tests; Mifepristone; Mineralocorticoid Receptor Antagonists; Spironolactone; Swine | 2010 |
An unusual case of an aldosterone-producing adrenocortical adenoma presenting with rhabdomyolysis.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Combined Modality Therapy; Female; Humans; Hypokalemia; Mineralocorticoid Receptor Antagonists; Rhabdomyolysis; Spironolactone; Tomography, X-Ray Computed; Treatment Outcome | 2009 |
Aldosterone and cortisol acutely stimulate Na+/H+ exchanger activity in the syncytiotrophoblast of the human placenta: effect of fetal sex.
Topics: Aldosterone; Female; Humans; Hydrocortisone; Infant, Newborn; Male; Mifepristone; Placenta; Pregnancy; Sex Factors; Sodium-Hydrogen Exchangers; Spironolactone; Trophoblasts | 2010 |
Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction.
Topics: Aldosterone; Binding, Competitive; Canrenoic Acid; Canrenone; Drug Interactions; Glucuronosyltransferase; Humans; Hymecromone; In Vitro Techniques; Kidney; Microsomes; Microsomes, Liver; Spironolactone | 2010 |
The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Topics: Aldosterone; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, T-Type; Cell Line; Dihydropyridines; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Models, Molecular; Molecular Conformation; Mutation; Pyridines; Receptors, Mineralocorticoid; Spironolactone; Stereoisomerism | 2010 |
[Effect of aldosterone and its antagonist spironolactone on epithelial-mesenchymal transition of normal rat kidney epithelial cells in high glucose].
Topics: Aldosterone; Animals; Cell Differentiation; Cell Line; Cells, Cultured; Diabetic Nephropathies; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Kidney Tubules; Mesoderm; Rats; Spironolactone | 2010 |
Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice.
Topics: Acetylcholine; Aldosterone; Animals; Caveolin 1; Eplerenone; Male; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Models, Animal; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Receptors, Mineralocorticoid; Signal Transduction; Sodium Chloride, Dietary; Spironolactone; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite.
Topics: Aldosterone; Animals; Appetite; Captopril; Desoxycorticosterone; Drug Interactions; Furosemide; Hyponatremia; Hypothalamic Area, Lateral; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Potassium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin; Renin-Angiotensin System; Reward; Self Stimulation; Sodium; Spironolactone | 2010 |
Aldosterone receptor inhibition alters the viscoelastic biomechanical behavior of the aortic wall.
Topics: Aldosterone; Animals; Aorta; Biomechanical Phenomena; Blood Pressure; Disease Progression; Elasticity; Eplerenone; Hyperlipidemias; Male; Mineralocorticoid Receptor Antagonists; Rabbits; Spironolactone; Viscosity | 2010 |
Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brain; Cardenolides; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fadrozole; Heart Rate; Hypothalamus; Imidazoles; Immunoglobulin Fab Fragments; Immunohistochemistry; Infusion Pumps, Implantable; Infusions, Parenteral; Infusions, Subcutaneous; Male; Mineralocorticoid Receptor Antagonists; Neural Pathways; Neurons; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Wistar; Renin-Angiotensin System; Saponins; Spironolactone; Subfornical Organ; Telemetry; Time Factors | 2010 |
Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin.
Topics: Adult; Aldosterone; Biopsy; Cells, Cultured; Cicatrix; Collagen Type I; Elasticity; Elastin; Eplerenone; Extracellular Matrix; Female; Fibroblasts; Gene Expression; Humans; Keloid; Mineralocorticoid Receptor Antagonists; Organ Culture Techniques; Receptor, IGF Type 1; RNA, Messenger; Skin; Spironolactone; Up-Regulation | 2010 |
Aldosterone inhibition and cardiovascular protection: more important than it once appeared.
Topics: Aldosterone; Atherosclerosis; Blood Vessels; Cardiomegaly; Cardiotonic Agents; Endothelium; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Multicenter Studies as Topic; Myocardial Infarction; Myocardium; Receptors, Mineralocorticoid; Sleep Apnea Syndromes; Spironolactone; Ventricular Remodeling | 2010 |
Inhibition of the renal renin-angiotensin system and renoprotection by pitavastatin in type1 diabetes.
Topics: Aldosterone; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Kidney; Male; Peptidyl-Dipeptidase A; Quinolines; Rats; Rats, Wistar; Renin-Angiotensin System; Spironolactone | 2010 |
Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone.
Topics: Aldosterone; Angiotensin II; Animals; Cell Size; Cells, Cultured; Cricetinae; Flow Cytometry; Membrane Transport Proteins; Myocytes, Cardiac; Spironolactone | 2010 |
Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats.
Topics: Albuminuria; Aldosterone; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Benzimidazoles; Benzoates; Blotting, Western; Calcium Channel Blockers; Eplerenone; Immunoenzyme Techniques; Kidney Glomerulus; Male; Membrane Proteins; Mineralocorticoid Receptor Antagonists; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Telmisartan | 2011 |
Aldosterone and angiogenesis.
Topics: Aldosterone; Animals; Dogs; Eplerenone; Mineralocorticoid Receptor Antagonists; Neovascularization, Physiologic; Rats; Rats, Wistar; Spironolactone | 2010 |
Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Topics: Acid-Base Equilibrium; Acidosis; Administration, Oral; Aldosterone; Animals; Bicarbonates; Calcium Gluconate; Dietary Supplements; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Eplerenone; Female; Glomerular Filtration Rate; Kidney; Male; Microdialysis; Mineralocorticoid Receptor Antagonists; Nephrectomy; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Renal Insufficiency; Spironolactone; Time Factors | 2010 |
Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.
Topics: Aldosterone; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Endothelium, Vascular; Eplerenone; Female; Humans; Hyperaldosteronism; Male; Mice; Middle Aged; Mineralocorticoid Receptor Antagonists; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone; Stem Cells; Vasodilation | 2011 |
Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor.
Topics: Aldosterone; Amino Acid Sequence; Animals; Antihypertensive Agents; Cell Line; Desoxycorticosterone; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Molecular Sequence Data; Nimodipine; Receptors, Mineralocorticoid; Sequence Alignment; Sequence Analysis, DNA; Spironolactone; Transcriptional Activation; Zebrafish | 2011 |
Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression.
Topics: Aldosterone; Animals; Blood Pressure; Fibrosis; Heart; Immediate-Early Proteins; Interleukin-1; Male; Matrix Metalloproteinase 2; NADPH Oxidases; Nitric Oxide Synthase Type III; Organ Size; Phosphotransferases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium Chloride; Spironolactone; Systole; Time Factors; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha | 2011 |
Overnight rostral fluid shift and obstructive sleep apnea in treatment resistant hypertension: connecting the dots clarifies the picture.
Topics: Aldosterone; Blood Volume; Drug Resistance; Fluid Shifts; Humans; Hypertension; Insulin Resistance; Renin; Sleep Apnea, Obstructive; Spironolactone | 2010 |
Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney.
Topics: Acetylglucosaminidase; Aldosterone; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Eplerenone; Humans; Hydralazine; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sirtuin 1; Spironolactone; Tumor Suppressor Protein p53 | 2011 |
[Aldosterone exacerbates chronic renal insufficiency].
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renal Insufficiency, Chronic; Risk Factors; Spironolactone | 2011 |
Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4.
Topics: Acetophenones; Aldosterone; Animals; Blood Pressure; Blotting, Western; Body Weight; Dinoprost; Eplerenone; Male; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide; Protein Subunits; Proteinuria; Rats; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary; Spironolactone; Systole; Urinalysis | 2011 |
Eplerenone in mild heart failure.
Topics: Aldosterone; Cardiovascular Diseases; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Sodium, Dietary; Spironolactone; Stroke Volume | 2011 |
Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism.
Topics: Aldosterone; Angiotensin II; Animals; Astrocytes; Cells, Cultured; DNA Damage; Eplerenone; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone; Tetrazoles; Valine; Valsartan | 2011 |
Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats.
Topics: Aldosterone; Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Carotid Arteries; Drug Therapy, Combination; Endothelium, Vascular; Eplerenone; Heart; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Spironolactone; Superoxides; Treatment Outcome | 2011 |
Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats.
Topics: Acute Kidney Injury; Aldosterone; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Eplerenone; Hypertension; Imidazoles; Immunohistochemistry; Kidney; Male; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride; Spironolactone; Tetrazoles | 2011 |
Aldosterone induction of hepatic stellate cell contraction through activation of RhoA/ROCK-2 signaling pathway.
Topics: Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cell Size; Cells, Cultured; Hepatic Stellate Cells; Irbesartan; Male; Mineralocorticoid Receptor Antagonists; Myosin Light Chains; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spironolactone; Stress Fibers; Tetrazoles | 2011 |
Prognostic value of plasma renin activity in heart failure.
Topics: Aged; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Death, Sudden; Defibrillators, Implantable; Diuretics; Electric Countershock; Female; Follow-Up Studies; Heart Failure; Humans; Male; Multivariate Analysis; Myocardial Infarction; Natriuretic Peptide, Brain; Norepinephrine; Peptide Fragments; Potassium; Prognosis; Proportional Hazards Models; Prospective Studies; Renin; ROC Curve; Sensitivity and Specificity; Sodium; Spironolactone; Stroke Volume | 2011 |
[The EMPHASIS-HF study].
Topics: Aldosterone; Biomarkers; Canrenone; Cause of Death; Double-Blind Method; Early Termination of Clinical Trials; Eplerenone; Female; Heart Failure; Hospitalization; Humans; Hyperkalemia; Male; Mineralocorticoid Receptor Antagonists; Models, Cardiovascular; Molecular Structure; Multicenter Studies as Topic; Myocardial Infarction; Patient Selection; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Research Design; Risk; Spironolactone | 2011 |
Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways.
Topics: Aldosterone; Animals; Aorta; Atherosclerosis; Cells, Cultured; Dactinomycin; Endothelium, Vascular; Gene Expression Profiling; Gene Expression Regulation; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Myocytes, Smooth Muscle; Oxidative Stress; RNA, Messenger; Spironolactone | 2011 |
Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells.
Topics: Aldosterone; Animals; Aorta, Thoracic; Cells, Cultured; Eplerenone; Lipopolysaccharides; Male; Mifepristone; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Spironolactone; Steroids | 2011 |
Transcriptome analysis of aldosterone-regulated genes in human vascular endothelial cell lines stably expressing mineralocorticoid receptor.
Topics: Aldosterone; Animals; Aorta; Cell Line; Endothelial Cells; Endothelium, Vascular; Gene Expression; Genes; Genes, Reporter; Humans; Hypertension; Luciferases, Firefly; Mineralocorticoid Receptor Antagonists; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone; Transcriptome | 2011 |
Glucocorticoid and mineralocorticoid receptors regulate paracellular permeability in a primary cultured gill epithelium.
Topics: Aldosterone; Animals; Cell Membrane Permeability; Cells, Cultured; Desoxycorticosterone; Dexamethasone; Electric Impedance; Epithelial Cells; Epithelium; Eplerenone; Fish Proteins; Gene Expression Regulation; Gills; Hydrocortisone; Mifepristone; Mineralocorticoid Receptor Antagonists; Oncorhynchus mykiss; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Tight Junctions | 2011 |
Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney.
Topics: Albuminuria; Aldosterone; Animals; Blood Pressure; Eplerenone; Fibrosis; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Osteopontin; Oxidative Stress; Sodium Chloride, Dietary; Spironolactone | 2011 |
Spironolactone prevents the inducibility of ventricular tachyarrhythmia in rats with aldosteronism.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Collagen; Electric Stimulation; Electrocardiography; Endomyocardial Fibrosis; Epicardial Mapping; Heart Rate; Hyperaldosteronism; Male; Rats; Rats, Sprague-Dawley; Spironolactone; Tachycardia, Ventricular | 2011 |
Quality of life in patients with bilateral primary aldosteronism before and during treatment with spironolactone and/or amiloride, including a comparison with our previously published results in those with unilateral disease treated surgically.
Topics: Adrenalectomy; Adult; Aged; Aldosterone; Amiloride; Australia; Diuretics; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Male; Mental Health; Middle Aged; Mineralocorticoid Receptor Antagonists; Quality of Life; Renin; Social Support; Spironolactone; Surveys and Questionnaires; Treatment Outcome | 2011 |
Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors.
Topics: 3T3-L1 Cells; Adipocytes; Aldosterone; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Corticosterone; Culture Media, Conditioned; Eplerenone; Fadrozole; Fibronectins; Hormone Antagonists; Mice; Mice, Inbred C57BL; Mifepristone; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Receptor, Angiotensin, Type 1; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 2011 |
Delineating the receptor mechanisms underlying the rapid vascular contractile effects of aldosterone and estradiol.
Topics: Aldosterone; Animals; Cells, Cultured; Eplerenone; Estradiol; Estrogen Receptor alpha; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Phosphorylation; Rats; Rats, Inbred WKY; Receptors, G-Protein-Coupled; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Tamoxifen; Vasoconstriction | 2011 |
The effect of treatment on monocyte and lymphocyte cytokine release in patients with aldosteronoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Aldosterone; Blood Pressure; Cytokines; Eplerenone; Female; Humans; Lymphocytes; Mineralocorticoid Receptor Antagonists; Monocytes; Spironolactone | 2012 |
Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.
Topics: Aldosterone; Animals; Blood Pressure; Blotting, Western; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Female; Hyperglycemia; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Spironolactone; Time Factors; Transforming Growth Factor beta1 | 2012 |
A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone.
Topics: Aldosterone; Animals; Blood Pressure; Blotting, Western; Collagen; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Rate; Hyperaldosteronism; Hypertension; Hypertrophy, Left Ventricular; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sodium Chloride, Dietary; Spironolactone; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2011 |
Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Topics: Aldosterone; Animals; Blood Pressure; Chronic Disease; Creatinine; Disease Models, Animal; Disease Progression; Electrolytes; Eplerenone; Heart Rate; Hypertension, Renal; Kidney; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Rats; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone | 2011 |
What is the role of aldosterone excess in resistant hypertension and how should it be investigated and treated?
Topics: Aldosterone; Eplerenone; Female; Humans; Hyperaldosteronism; Hyperkalemia; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Practice Guidelines as Topic; Spironolactone | 2011 |
Blockade of mineralocorticoid and glucocorticoid receptors reverses stress-induced motor impairments.
Topics: Aldosterone; Animals; Blood Glucose; Corticosterone; Dexamethasone; Female; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Motor Activity; Motor Skills; Rats; Receptors, Glucocorticoid; Restraint, Physical; Spironolactone; Stress, Physiological | 2011 |
Mineralocorticoid receptor antagonists for heart failure.
Topics: Aldosterone; Animals; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone | 2011 |
Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines.
Topics: Aldosterone; Amiloride; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hydrocortisone; Hydrogen-Ion Concentration; Liver Neoplasms; Mineralocorticoid Receptor Antagonists; Neuroprotective Agents; Oncolytic Virotherapy; Rabbits; Spironolactone; Vaccinia virus; Virus Replication | 2011 |
Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice.
Topics: Actins; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Eplerenone; Genes, p16; Genes, p53; Hydralazine; Hypertension; Imidazoles; Kidney; Mice; Mice, Inbred C57BL; p21-Activated Kinases; Sirtuin 1; Sodium Chloride; Spironolactone; Tetrazoles | 2012 |
Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure.
Topics: Aldosterone; Animals; Cell Proliferation; Echocardiography; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Myofibroblasts; Rats; Rats, Wistar; Spironolactone; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Action of ANP on the nongenomic dose-dependent biphasic effect of aldosterone on NHE1 in proximal S3 segment.
Topics: Acid-Base Equilibrium; Aldosterone; Ammonium Chloride; Animals; Atrial Natriuretic Factor; Calcium Signaling; Chelating Agents; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Male; Microdissection; Mifepristone; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Spironolactone | 2012 |
Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor.
Topics: Aldosterone; Animals; Aorta, Thoracic; Blood Pressure; Cells, Cultured; Chimera; Eplerenone; Glucose; Hypertrophy; Insulin; Insulin Resistance; Male; Models, Animal; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Spironolactone; Up-Regulation | 2012 |
Endogenous aldosterone is involved in vascular calcification in rat.
Topics: Aldosterone; Alkaline Phosphatase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Calcium; Captopril; Cholecalciferol; Collagen; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Nicotine; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Vascular Calcification | 2012 |
Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cell Survival; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Reperfusion Injury; Retinal Diseases; Spironolactone; Tetrazoles | 2012 |
Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma.
Topics: Aldosterone; Angiogenesis Inhibitors; Animals; Collagen; Down-Regulation; Drug Combinations; Endothelium; Eplerenone; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Morphogenesis; Neovascularization, Physiologic; PPAR gamma; Proteoglycans; Spironolactone; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampus.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biophysics; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Inhibition; Patch-Clamp Techniques; Rats; Rats, Wistar; Reaction Time; Seizures; Spironolactone; Stress, Psychological; Synapses; Time Factors | 2012 |
Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Blood Pressure; Eplerenone; Hypertension; Male; Medulla Oblongata; Microinjections; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Mineralocorticoid; Spironolactone; Stroke; Sympathetic Nervous System | 2012 |
Antiapolipoprotein A-1 IgG chronotropic effects require nongenomic action of aldosterone on L-type calcium channels.
Topics: Aldosterone; Animals; Animals, Newborn; Apolipoprotein A-I; Calcium Channels, L-Type; Cells, Cultured; Dactinomycin; Electrophysiology; Eplerenone; Immunoglobulin G; Myocytes, Cardiac; Oxidation-Reduction; Oxygen; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone; Time Factors | 2012 |
Sex-specific effects of spironolactone on blood pressure in gonadectomized male and female Wistar rats.
Topics: Aldosterone; Animals; Blood Pressure; Female; Gonads; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sex Factors; Spironolactone | 2012 |
Antihypertensive and cardiorenal protective effects of SM-368229, a novel mineralocorticoid receptor antagonist, in aldosterone/salt-treated rats.
Topics: Acetylglucosaminidase; Aldosterone; Animals; Antihypertensive Agents; Benzoxazines; Biomarkers; Blood Pressure; Disease Models, Animal; Gene Expression; Heart; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Organ Size; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone; Sulfonamides | 2012 |
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus.
Topics: Aldosterone; Animals; Corticosterone; Hippocampus; Mice; Mineralocorticoid Receptor Antagonists; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Trimethyltin Compounds | 2012 |
Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1.
Topics: Aldosterone; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart; Immediate-Early Proteins; Inflammation; Isoproterenol; Male; Mineralocorticoid Receptor Antagonists; Oxidation-Reduction; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone | 2012 |
Unilateral primary aldosteronism with spontaneous remission after long-term spironolactone therapy.
Topics: Adrenal Gland Neoplasms; Adult; Aldosterone; Antihypertensive Agents; Cardiomegaly; Enalapril; Humans; Hyperaldosteronism; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Remission Induction; Spironolactone; Tumor Burden | 2012 |
Predictive factors of left ventricular mass changes after treatment of primary aldosteronism.
Topics: Adrenalectomy; Adult; Aldosterone; Blood Pressure; Female; Heart Ventricles; Humans; Hyperaldosteronism; Hypertrophy, Left Ventricular; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Spironolactone | 2012 |
Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients.
Topics: Adipocytes; Adiponectin; Adult; Aged; Aldosterone; Carrier Proteins; Cells, Cultured; Down-Regulation; Eplerenone; Female; Gene Expression; Humans; Hyperaldosteronism; Insulin Resistance; Intra-Abdominal Fat; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Perilipin-1; Phosphoenolpyruvate Carboxykinase (GTP); Phosphoproteins; Potassium; PPAR gamma; Spironolactone | 2012 |
Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation.
Topics: Acute Kidney Injury; Adrenalectomy; Aldosterone; Analysis of Variance; Angiotensin II; Animals; Blotting, Western; Disease Models, Animal; Eplerenone; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; rac1 GTP-Binding Protein; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Mineralocorticoid; Signal Transduction; Sodium Chloride, Dietary; Spironolactone; Statistics, Nonparametric | 2012 |
Update on aldosterone antagonists use in heart failure with reduced left ventricular ejection fraction. Heart Failure Society of America Guidelines Committee.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Eplerenone; Heart; Heart Failure; Hospitalization; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Randomized Controlled Trials as Topic; Spironolactone; Stroke Volume; Ventricular Dysfunction, Left | 2012 |
Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat.
Topics: Actins; Aldosterone; Animals; Cyclic GMP-Dependent Protein Kinases; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth; Nitric Oxide; Polymerase Chain Reaction; Portal Pressure; Rats; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Spironolactone | 2012 |
Recovery from ischemic acute kidney injury by spironolactone administration.
Topics: Acute Kidney Injury; Aldosterone; Animals; Drug Administration Schedule; HSP72 Heat-Shock Proteins; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renal Circulation; Reperfusion Injury; Spironolactone; Up-Regulation | 2012 |
Aldosterone inhibits antifibrotic factors in mouse hypertensive heart.
Topics: Aldosterone; Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Pressure; Blotting, Western; Bone Morphogenetic Protein 4; Cells, Cultured; Cytochrome P-450 CYP11B2; Eplerenone; Female; Fibrosis; Galectin 3; Gene Expression; Hyperaldosteronism; Hypertension; Male; Mice; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Myocardium; Natriuretic Peptide, Brain; Organ Size; Renin; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone | 2012 |
Additive amelioration of oxidative stress and cardiac function by combined mineralocorticoid and angiotensin receptor blockers in postinfarct failing hearts.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Drug Therapy, Combination; Heart Failure; Hemodynamics; Imidazoles; Lipid Peroxidation; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone; Tetrazoles; Ventricular Function, Left | 2012 |
Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase.
Topics: Acetophenones; Aldosterone; Animals; Blood Pressure; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Eplerenone; Epoprostenol; Heart Rate; Immunohistochemistry; Kidney; Male; Membrane Proteins; Rats; Rats, Inbred Dahl; Spironolactone; Systole; Vasoconstrictor Agents | 2012 |
Spironolactone prevents aldosterone induced increased duration of atrial fibrillation in rat.
Topics: Action Potentials; Aldosterone; Animals; Atrial Fibrillation; Blood Pressure; Blotting, Western; Male; Rats; Rats, Wistar; Spironolactone | 2012 |
Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Biomarkers; Blood Pressure; Cytochrome P-450 CYP11B2; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Diseases; Inflammation; Kidney Diseases; Kidney Glomerulus; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Myocardium; Receptors, Mineralocorticoid; Renin-Angiotensin System; Sodium Chloride, Dietary; Spironolactone; Time Factors; Vascular Diseases | 2012 |
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.
Topics: Adult; Aldosterone; Animals; Central Serous Chorioretinopathy; Choroid; Corticosterone; Eplerenone; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Mineralocorticoid; Retina; Signal Transduction; Small-Conductance Calcium-Activated Potassium Channels; Spironolactone; Treatment Outcome; Vasodilation; Vasodilator Agents; Visual Acuity | 2012 |
Rapid, dynamic changes in glomerular permeability to macromolecules during systemic angiotensin II (ANG II) infusion in rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Ficoll; Glomerular Filtration Rate; Infusions, Intravenous; Kidney Glomerulus; Male; Mineralocorticoid Receptor Antagonists; Nimodipine; Permeability; Rats; Rats, Wistar; Spironolactone; Tetrazoles; Vasodilator Agents | 2012 |
Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.
Topics: Aldosterone; Animals; Cells, Cultured; Cysteine; Disease Models, Animal; Endothelial Cells; Endothelin-1; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Male; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pulmonary Artery; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Spironolactone; Sulfhydryl Compounds | 2012 |
Increased microparticle production and impaired microvascular endothelial function in aldosterone-salt-treated rats: protective effects of polyphenols.
Topics: Aldosterone; Animals; Antioxidants; Aorta; Arterial Pressure; Cell-Derived Microparticles; Endothelium, Vascular; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Polyphenols; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium Chloride; Spironolactone; Superoxides; Vascular Stiffness; Vasodilation | 2012 |
Targeting activated mineralocorticoid receptor: Occam's razor revisited.
Topics: Aldosterone; Angiotensin II; Animals; Heart Diseases; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone; Vascular Diseases | 2012 |
Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.
Topics: Aldosterone; Analysis of Variance; Animals; Aorta; Disease Models, Animal; Gene Expression; Graft Rejection; Humans; Immunoblotting; Immunohistochemistry; Mice; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Up-Regulation; Vascular Patency; Vena Cava, Inferior | 2013 |
Quality of life in patients with primary aldosteronism: gender differences in untreated and long-term treated patients and associations with treatment and aldosterone.
Topics: Adrenalectomy; Aged; Aldosterone; Female; Germany; Humans; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Quality of Life; Registries; Renin; Spironolactone; Surveys and Questionnaires; Time Factors | 2012 |
Aldosterone is not involved in the ventricular remodeling process induced by tobacco smoke exposure.
Topics: Aldosterone; Animals; Cardiovascular Diseases; Dietary Supplements; Echocardiography; Male; Rats; Rats, Wistar; Smoking; Spironolactone; Tobacco Smoke Pollution; Ventricular Remodeling | 2012 |
Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.
Topics: Acute Kidney Injury; Aldosterone; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Endothelin-1; Histone-Lysine N-Methyltransferase; Humans; Methyltransferases; Mice; Nuclear Proteins; Promoter Regions, Genetic; Rats; Spironolactone; Streptozocin; Up-Regulation | 2012 |
Changes in microRNAs associated with podocytic adhesion damage under mechanical stress.
Topics: 3' Untranslated Regions; Aldosterone; Base Sequence; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Computational Biology; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation; Humans; Integrin alpha3beta1; MicroRNAs; Oligonucleotide Array Sequence Analysis; Podocytes; Protein Serine-Threonine Kinases; Receptors, Mineralocorticoid; Spironolactone; Stress, Mechanical; Up-Regulation | 2013 |
Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo.
Topics: Aldosterone; Animals; Apoptosis; Blood Pressure; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic N-Oxides; DNA Damage; Hydralazine; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spin Labels; Spironolactone | 2013 |
The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Animals; Anti-Inflammatory Agents; Aqueous Humor; Chemokines; Ciliary Body; Down-Regulation; Endotoxins; Female; Humans; Inflammation Mediators; Intravitreal Injections; Iris; Lipopolysaccharides; Microglia; Rats; Rats, Inbred Lew; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Uveitis | 2012 |
Idiopathic intracranial hypertension associated with either primary or secondary aldosteronism.
Topics: Adolescent; Adult; Aldosterone; Child; Electrolytes; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Pseudotumor Cerebri; Renin; Spironolactone | 2013 |
Mineralocorticoid receptor blockade inhibits accelerated atherosclerosis induced by a low sodium diet in apolipoprotein E-deficient mice.
Topics: Aldosterone; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Biomarkers; Diet, Sodium-Restricted; Eplerenone; Humans; Inflammation; Macrophages, Peritoneal; Mice; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin; Renin-Angiotensin System; Spironolactone | 2014 |
Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes.
Topics: Aldosterone; Animals; Annexin A5; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase 3; Cell Survival; Cells, Cultured; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Mitochondria; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Signal Transduction; Spironolactone; Up-Regulation | 2013 |
Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in vivo.
Topics: Aldosterone; Animals; Connective Tissue Growth Factor; Eplerenone; Mice; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Receptors, Mineralocorticoid; Spironolactone; Transcriptome | 2013 |
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
Topics: Aldosterone; Animals; Cell Differentiation; Cells, Cultured; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glucuronidase; Humans; Klotho Proteins; Mice; Mice, Knockout; Osteoblasts; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Spironolactone; Transcription Factor Pit-1; Vascular Calcification | 2013 |
Aldosterone is synthesized in and activates bulbospinal neurons through mineralocorticoid receptors and ENaCs in the RVLM.
Topics: Aldosterone; Amiloride; Animals; Aromatase Inhibitors; Calcium; Diuretics; Epithelial Sodium Channels; Eplerenone; Excitatory Postsynaptic Potentials; Fadrozole; Magnesium; Medulla Oblongata; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spinal Cord; Spironolactone; Tissue Fixation | 2013 |
Rho kinase pathway is likely responsible for the profibrotic actions of aldosterone in renal epithelial cells via inducing epithelial-mesenchymal transition and extracellular matrix excretion.
Topics: Actins; Aldosterone; Amides; Cadherins; Cell Line; Collagen Type I; Collagen Type III; Epithelial Cells; Epithelial-Mesenchymal Transition; Eplerenone; Extracellular Matrix; Gene Expression Regulation; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Protein Kinase Inhibitors; Pyridines; Receptors, Mineralocorticoid; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Spironolactone | 2013 |
Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension.
Topics: Aldosterone; Animals; Arterial Pressure; Body Weight; Cardiac Output; Cell Proliferation; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Mice; Mineralocorticoid Receptor Antagonists; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Receptors, Mineralocorticoid; Spironolactone; Vascular Resistance; Ventricular Remodeling | 2013 |
Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats.
Topics: Active Transport, Cell Nucleus; Aldosterone; Animals; Blood Pressure; Cardiomegaly; Cell Nucleus; Eplerenone; Humans; Hydrocortisone; Hypertension; Macrophages; Mineralocorticoid Receptor Antagonists; Muscle Proteins; Myocarditis; Myocardium; p21-Activated Kinases; Phosphorylation; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Spironolactone; Ventricular Remodeling | 2013 |
Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.
Topics: Aldosterone; Amiloride; Angiotensin II; Animals; Blood Pressure; DNA Primers; Gene Expression Regulation; Glomerular Filtration Rate; Hyperaldosteronism; Mice; Mice, Inbred C57BL; Natriuresis; Polymerase Chain Reaction; Renin; Sodium-Potassium-Exchanging ATPase; Spironolactone; Transforming Growth Factor beta1; Urinalysis | 2013 |
The effects of aldosterone on diet-induced fatty liver formation in male C57BL/6 mice: comparison of adrenalectomy and mineralocorticoid receptor blocker.
Topics: Adrenalectomy; Aldosterone; Animals; Blood Glucose; Blood Pressure; Cells, Cultured; Cholesterol; Diet, High-Fat; Disease Models, Animal; Eplerenone; Fatty Liver; Hepatocytes; Insulin; Insulin Resistance; Lipoproteins, VLDL; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Oleic Acid; Spironolactone; Triglycerides; Weight Gain | 2013 |
Eplerenone promotes alternative activation in human monocyte-derived macrophages.
Topics: Adolescent; Adult; Aldosterone; Arginase; Cells, Cultured; Eplerenone; Female; Gene Expression Regulation; Humans; Lectins, C-Type; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Receptors, Cell Surface; Spironolactone; Young Adult | 2013 |
Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity.
Topics: Adipose Tissue; Aldosterone; Animals; Antioxidants; Aorta; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Diet, High-Fat; Endothelium, Vascular; Eplerenone; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperglycemia; Inflammation; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Obesity; Oxidative Stress; Receptors, Mineralocorticoid; Spironolactone; Superoxide Dismutase; Superoxide Dismutase-1; Up-Regulation | 2013 |
Renin angiotensin antagonists normalize aberrant activation of epithelial sodium channels in sodium-sensitive hypertension.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Down-Regulation; Epithelial Sodium Channels; Eplerenone; Hypertension; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Perindopril; Renin; Sodium; Sodium Chloride, Dietary; Spironolactone; Tetrazoles | 2012 |
Spironolactone prevents dietary-induced metabolic syndrome by inhibiting PI3-K/Akt and p38MAPK signaling pathways.
Topics: Aldosterone; Animals; Apoptosis; Diet, High-Fat; Dyslipidemias; Hypertension; Insulin-Secreting Cells; Male; MAP Kinase Signaling System; Metabolic Syndrome; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone | 2013 |
Spironolactone inhibits apoptosis in rat mesangial cells under hyperglycaemic conditions via the Wnt signalling pathway.
Topics: Aldosterone; Animals; Apoptosis; beta Catenin; Blotting, Western; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lithium Chloride; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Rats; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone; Wnt Proteins; Wnt Signaling Pathway; Wnt-5a Protein; Wnt4 Protein | 2013 |
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Apoptosis; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Elastin; Enalapril; Eplerenone; Losartan; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Oxidative Stress; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Time Factors | 2013 |
Echocardiographic effects of eplerenone and aldosterone in hypertensive rats.
Topics: Aldosterone; Animals; Echocardiography; Eplerenone; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spironolactone | 2013 |
Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-β1.
Topics: Adolescent; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Child; Creatinine; Enalapril; Female; Humans; Kidney Function Tests; Male; Mineralocorticoid Receptor Antagonists; Mutation; Nephritis, Hereditary; Proteinuria; Spironolactone; Transforming Growth Factor beta1; Treatment Outcome; Young Adult | 2013 |
Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma.
Topics: Aldosterone; Animals; Apoptosis; Cell Survival; Glaucoma; Intraocular Pressure; Male; Mineralocorticoid Receptor Antagonists; Nerve Degeneration; Optic Nerve; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Spironolactone | 2013 |
Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain.
Topics: Adenosine Triphosphate; Aldosterone; Annexin A1; Binding Sites; Boron Compounds; Calpain; Eplerenone; Gene Expression Regulation; HEK293 Cells; Humans; Ion Transport; Magnesium; NADPH Oxidases; Phosphorylation; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Reactive Oxygen Species; Signal Transduction; Spectrin; Spironolactone; TRPM Cation Channels | 2013 |
Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Brain; Corticosterone; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Eplerenone; Fadrozole; Heart Rate; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone | 2013 |
The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes.
Topics: Active Transport, Cell Nucleus; Aldosterone; Animals; Cell Nucleus; Chlorocebus aethiops; COS Cells; Diuretics; Green Fluorescent Proteins; Humans; Immediate-Early Proteins; Luciferases; Mice; Microscopy, Confocal; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Orosomucoid; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Rats; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; Serpins; Spironolactone; Sulfonamides; Tenascin; Torsemide; Transcriptional Activation | 2013 |
Predictors of malignancy in primary aldosteronism.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Aldosterone; Cell Transformation, Neoplastic; Female; Germany; Humans; Hyperaldosteronism; Male; Middle Aged; Potassium; Preoperative Care; Renin; Retrospective Studies; Risk Factors; Spironolactone; Tumor Burden | 2014 |
[Effect of angiotensin II and aldosterone on the proliferation of cardiac fibroblasts in rats].
Topics: Aldosterone; Angiotensin II; Animals; Cell Proliferation; Collagen; Fibroblasts; Losartan; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2013 |
Aldosterone aggravates glucose intolerance induced by high fructose.
Topics: Aldosterone; Animals; Blood Glucose; Fructose; Glucose Intolerance; Glucose Tolerance Test; Immediate-Early Proteins; Insulin; Insulin Resistance; Male; Mineralocorticoid Receptor Antagonists; Muscle, Skeletal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2013 |
Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone.
Topics: Aldosterone; Animals; Eplerenone; Estradiol; Estrus; Female; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Kidney Tubules, Distal; Loop of Henle; Low Density Lipoprotein Receptor-Related Protein-2; Mice; Mineralocorticoid Receptor Antagonists; Protein Binding; Receptors, Estrogen; Receptors, G-Protein-Coupled; Receptors, Mineralocorticoid; Reproduction; Spironolactone | 2014 |
Aldosterone blockade reduces mortality without changing cardiac remodeling in spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Electrocardiography; Gene Expression Regulation; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Papillary Muscles; Rats; Rats, Inbred SHR; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spironolactone; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Modulation of aldosterone levels by -344 C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension.
Topics: Aged; Aldosterone; Alleles; Blood Pressure; Cytochrome P-450 CYP11B2; DNA; Female; Genotype; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Polymorphism, Genetic; Spironolactone | 2014 |
Eplerenone mimics features of the alternative activation in macrophages obtained from patients with heart failure and healthy volunteers.
Topics: Aged; Aldosterone; Arginase; Cell Survival; Drug Interactions; Eplerenone; Female; Gene Expression Regulation; Healthy Volunteers; Heart Failure; Humans; Interleukin-4; Lectins, C-Type; Macrophage Activation; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Middle Aged; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase Type II; Phenotype; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, Mineralocorticoid; Spironolactone; Superoxide Dismutase | 2014 |
Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling.
Topics: Aldosterone; Alkaloids; Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; BH3 Interacting Domain Death Agonist Protein; Calpain; Caspase 3; Gene Expression Regulation; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Myocytes, Cardiac; Primary Cell Culture; Quinolizines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spironolactone | 2014 |
Aldosterone receptor blockers spironolactone and canrenone: two multivalent drugs.
Topics: Albuminuria; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Canrenone; Humans; Hypertension; Inflammation; Insulin Resistance; Mineralocorticoid Receptor Antagonists; Spironolactone | 2014 |
The velocity of home blood pressure reduction in response to low-dose eplerenone combined with other antihypertensive drugs determined by exponential decay function analysis.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Drug Therapy, Combination; Eplerenone; Female; Humans; Hypertension; Male; Middle Aged; Spironolactone; Treatment Outcome | 2014 |
Evidence for aldosterone-dependent growth of renal cell carcinoma.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; In Vitro Techniques; Kidney Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); raf Kinases; ras Proteins; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Tissue Array Analysis | 2014 |
Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice.
Topics: Adipocytes; Adipogenesis; Adipose Tissue, Brown; Adipose Tissue, White; Aldosterone; Androstenes; Animals; Autophagy; Body Composition; Cell Transdifferentiation; Cells, Cultured; Diet, High-Fat; Female; Gene Expression Profiling; Glucose Intolerance; Inguinal Canal; Intra-Abdominal Fat; Ion Channels; Macrolides; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Mitochondrial Proteins; Obesity; Receptors, Mineralocorticoid; Spironolactone; Uncoupling Protein 1; Up-Regulation; Weight Gain | 2014 |
Spironolactone inhibits production of proinflammatory mediators in response to lipopolysaccharide via inactivation of nuclear factor-κB.
Topics: Aldosterone; Animals; Cells, Cultured; Dinoprostone; I-kappa B Kinase; Inflammation Mediators; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide; Phosphorylation; Spironolactone; Tumor Necrosis Factor-alpha | 2014 |
The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Cilazapril; Dialysis Solutions; Disease Models, Animal; Drug Therapy, Combination; Lymphocytes; Macrophages; Male; Mineralocorticoid Receptor Antagonists; Peritoneal Dialysis, Continuous Ambulatory; Peritoneal Fibrosis; Peritoneum; Peritonitis; Random Allocation; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone; Transforming Growth Factor beta1 | 2014 |
Preconditioning actions of aldosterone through p38 signaling modulation in isolated rat hearts.
Topics: Aldosterone; Animals; Eplerenone; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Perfusion; Rats; Rats, Wistar; Signal Transduction; Spironolactone | 2014 |
Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30.
Topics: Aldosterone; Amiloride; Animals; Arterioles; Cycloheximide; Dactinomycin; Epithelial Sodium Channels; Eplerenone; Feedback; Kidney Tubules; Male; Rabbits; Receptors, G-Protein-Coupled; Receptors, Mineralocorticoid; Spironolactone | 2014 |
Interplay of parathyroid hormone and aldosterone antagonist in prevention of heart failure hospitalizations in chronic kidney disease.
Topics: Aged; Aldosterone; Case-Control Studies; Female; Heart Failure; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Mineralocorticoid Receptor Antagonists; Parathyroid Hormone; Renal Insufficiency, Chronic; Spironolactone | 2014 |
Cardiac macrophages and apoptosis after myocardial infarction: effects of central MR blockade.
Topics: Aldosterone; Animals; Apoptosis; Caspase 3; Disease Models, Animal; Eplerenone; Macrophages; Male; Myocardial Infarction; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone; Ventricular Remodeling | 2014 |
Aldosterone induces fibrosis, oxidative stress and DNA damage in livers of male rats independent of blood pressure changes.
Topics: Aldosterone; Animals; Blood Pressure; Blotting, Western; Cyclic N-Oxides; Histocytochemistry; Liver Cirrhosis; Male; Mineralocorticoid Receptor Antagonists; NF-E2-Related Factor 2; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA; Spin Labels; Spironolactone; Statistics, Nonparametric; Transforming Growth Factor beta | 2014 |
Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in rat heart through mineralocorticoid receptor blockade.
Topics: Aldosterone; Animals; Cell Line; Chlorocebus aethiops; Heart; Hypertension; Immediate-Early Proteins; Male; Mineralocorticoid Receptor Antagonists; Plant Extracts; Proanthocyanidins; Protein Serine-Threonine Kinases; Prunus; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone | 2014 |
The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.
Topics: Acute Kidney Injury; Aldosterone; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Galectin 3; Heart Failure; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Spironolactone | 2015 |
Non-genomic effects of spironolactone and eplerenone in cardiomyocytes of neonatal Wistar rats: do they evoke cardioprotective pathways?
Topics: Aldosterone; Animals; Calcium; Cell Proliferation; Cyclic AMP; Cyclic GMP; Eplerenone; Female; Male; MAP Kinase Signaling System; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Spironolactone | 2015 |
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Blood Pressure; Carotid Intima-Media Thickness; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prospective Studies; Spironolactone | 2015 |
Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity.
Topics: Adrenalectomy; Aldosterone; Animals; Chronic Disease; Cyclosporine; Cytochrome P-450 CYP11B2; Disease Models, Animal; Electrolytes; Eplerenone; Fibrosis; Kidney; Kidney Diseases; Male; Potassium; Rats, Sprague-Dawley; RNA, Messenger; Sodium; Spironolactone | 2015 |
Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; DNA Damage; DNA Repair; Enzyme Activation; Eplerenone; Guanosine; Heart; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Spin Labels; Spironolactone; Tetrazoles | 2014 |
Aldosterone Contributes to Sympathoexcitation in Renovascular Hypertension.
Topics: Actins; Aldosterone; Animals; Antihypertensive Agents; Arterial Pressure; Baroreflex; Disease Models, Animal; Heart Rate; Hypertension, Renovascular; Kidney; Male; Medulla Oblongata; Mineralocorticoid Receptor Antagonists; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Spironolactone; Sympathetic Nervous System | 2015 |
Unadjusted Plasma Renin Activity as a "First-Look" Test to Decide Upon Further Investigations for Primary Aldosteronism.
Topics: Adult; Aldosterone; Antihypertensive Agents; Body Mass Index; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Renin; Retrospective Studies; Spironolactone; Tomography, X-Ray Computed | 2015 |
Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase.
Topics: 3T3-L1 Cells; Adipocytes, White; Aldosterone; Animals; Cell Line, Tumor; Dibenzocycloheptenes; Enzyme Induction; Humans; Insulin Resistance; Intra-Abdominal Fat; Intramolecular Oxidoreductases; Lipocalins; Male; Metabolic Syndrome; Mice; Mice, Obese; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; Obesity; Piperidines; Receptors, Leptin; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Subcutaneous Fat; Up-Regulation | 2015 |
Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus.
Topics: Aldosterone; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ethidium; Glucocorticoids; Insulin; Male; Mice; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Potassium; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2015 |
Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension.
Topics: Adult; Aldosterone; Black or African American; Blood Pressure; Endothelium, Vascular; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Spironolactone; Vasodilation | 2015 |
Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
Topics: Administration, Oral; Adrenalectomy; Aldosterone; Animals; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Dose-Response Relationship, Drug; Eplerenone; Female; HEK293 Cells; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Potassium; Protein Binding; Pyrroles; Rabbits; Radioligand Assay; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium; Spironolactone; Sulfones; Transcriptional Activation; Transfection; Urological Agents; Water-Electrolyte Balance | 2015 |
Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury.
Topics: Aldosterone; Amines; Animals; Calmodulin-Binding Proteins; Male; Membrane Proteins; Mineralocorticoid Receptor Antagonists; Myocardial Reperfusion Injury; Nerve Tissue Proteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Mineralocorticoid; Reperfusion Injury; Signal Transduction; Spironolactone; Superoxides; Transcriptional Activation | 2015 |
Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways.
Topics: Aldosterone; Animals; Benzofurans; Calcium; Cell Communication; Cell Line; Cell Proliferation; Chromones; Connexin 43; Flavonoids; Fluorescent Dyes; Gap Junctions; Gene Expression Regulation; Indoles; Isoquinolines; Maleimides; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone | 2015 |
Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.
Topics: Aldosterone; Animals; Cell Line; Humans; Lisinopril; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Diseases; Receptors, Melanocortin; Spironolactone | 2015 |
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.
Topics: Active Transport, Cell Nucleus; Aldosterone; Blotting, Western; Cell Line; Cell Nucleus; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Sodium Channels; HEK293 Cells; Humans; Kinetics; Microscopy, Fluorescence; Mutation; Naphthyridines; Nuclear Receptor Coactivator 1; Promoter Regions, Genetic; Protein Binding; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transcriptional Activation | 2015 |
Mineralocorticoid Receptor Antagonism for Cardiovascular Protection in End-Stage Renal Disease: New Data But the Controversy Continues.
Topics: Aldosterone; Humans; Hypertension; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2016 |
Device therapy and aldosterone antagonists in the prognosis of heart failure.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Prognosis; Spironolactone | 2016 |
Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats.
Topics: Aldosterone; Animals; Arterial Pressure; Corticosterone; Cytochrome P-450 CYP11B2; Drinking Behavior; Eplerenone; Fadrozole; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptors, Mineralocorticoid; RNA, Messenger; Sodium Chloride; Spironolactone; Subfornical Organ; Supraoptic Nucleus | 2016 |
Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism.
Topics: Adrenalectomy; Adult; Aged; Aldosterone; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Drug Monitoring; Eplerenone; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Japan; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Reproducibility of Results; Risk; Spironolactone | 2016 |
Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.
Topics: Aldosterone; Animals; Fibrosis; Inflammation; Kidney; Kidney Diseases; Macrophages; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Sodium Chloride; Spironolactone | 2016 |
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages.
Topics: Aldosterone; Ceramides; Eplerenone; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Lysophospholipids; Membrane Proteins; Signal Transduction; Sphingosine; Sphingosine N-Acyltransferase; Spironolactone | 2016 |
Urinary sodium excretion predicts blood pressure response to spironolactone in patients with resistant hypertension independent of aldosterone status.
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Retrospective Studies; Sodium; Spironolactone; Treatment Outcome | 2016 |
Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER).
Topics: Aldosterone; Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Mineralocorticoid Receptor Antagonists; Neoplasm Metastasis; Neoplasms, Experimental; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering; Spironolactone | 2016 |
The story of spironolactones from 1957 to now: from sodium balance to inflammation.
Topics: Aldosterone; History, 20th Century; History, 21st Century; Hypertension; Inflammation; Mineralocorticoid Receptor Antagonists; Sodium; Spironolactone | 2016 |
Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor.
Topics: Aldosterone; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Cytokines; Endothelial Cells; Endothelium, Vascular; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Receptors, Mineralocorticoid; Spironolactone; Superoxides | 2016 |
Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice.
Topics: Aldosterone; Animals; Blood Pressure; Epithelial Sodium Channels; Eplerenone; Female; Hyperaldosteronism; Kidney; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Male; Mice, Inbred C57BL; Mice, Knockout; Polyuria; Potassium; Sodium, Dietary; Solute Carrier Family 12, Member 3; Spironolactone | 2016 |
Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.
Topics: Adrenal Glands; Aldosterone; Animals; Atrial Fibrillation; Electrophysiological Phenomena; Gene Expression Regulation; GTPase-Activating Proteins; Hyperaldosteronism; Kv1.5 Potassium Channel; Membrane Proteins; Mice; Mice, Knockout; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Proto-Oncogene Proteins c-akt; rab GTP-Binding Proteins; Spironolactone | 2016 |
Kaempferol inhibits the production of ROS to modulate OPN-αvβ3 integrin pathway in HUVECs.
Topics: Aldosterone; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antioxidants; Ascorbic Acid; Cells, Cultured; Down-Regulation; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Integrin alphaV; Integrin alphaVbeta3; Integrin beta3; Kaempferols; Mineralocorticoid Receptor Antagonists; NF-kappa B; Osteopontin; Reactive Oxygen Species; Signal Transduction; Spironolactone | 2016 |
Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?
Topics: A Kinase Anchor Proteins; Aldosterone; Animals; Atrial Natriuretic Factor; Cyclic AMP; Egtazic Acid; Heart Failure; Humans; Hypertrophy; Mitogen-Activated Protein Kinase 7; Myocytes, Cardiac; Phosphorylation; Primary Cell Culture; Protein Kinase C; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone | 2016 |
SFE/SFHTA/AFCE primary aldosteronism consensus: Introduction and handbook.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Calcium Channel Blockers; France; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 2016 |
Histone deacetylase inhibition, but not a mineralocorticoid receptor antagonist spironolactone, attenuates atypical transcription by an activating mutant MR (MRS 810L ).
Topics: Aldosterone; Amino Acid Sequence; Dose-Response Relationship, Drug; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Mineralocorticoid Receptor Antagonists; Mutation; Progesterone; Receptors, Mineralocorticoid; Spironolactone; Transcription, Genetic | 2016 |
Parathyroid hormone, aldosterone-to-renin ratio and fibroblast growth factor-23 as determinants of nocturnal blood pressure in primary hyperparathyroidism: the eplerenone in primary hyperparathyroidism trial.
Topics: Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium; Circadian Rhythm; Cross-Sectional Studies; Diastole; Eplerenone; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Hyperparathyroidism, Primary; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Parathyroid Hormone; Randomized Controlled Trials as Topic; Renin; Risk Factors; Sex Factors; Spironolactone; Systole | 2016 |
ARAs to the RESCUE.
Topics: Aldosterone; Eplerenone; Gynecomastia; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Meta-Analysis as Topic; Mineralocorticoid Receptor Antagonists; Spironolactone | 2016 |
Interleukin-18 deficiency protects against renal interstitial fibrosis in aldosterone/salt-treated mice.
Topics: Aldosterone; Animals; Blood Pressure; Fibrosis; Humans; Interleukin-18; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteopontin; Potassium; Sodium; Spironolactone | 2016 |
(Pro)Renin receptor regulates potassium homeostasis through a local mechanism.
Topics: Adrenalectomy; Aldosterone; Animals; Cytochrome P-450 CYP11B2; Disease Models, Animal; Epithelial Sodium Channels; Homeostasis; Hyperkalemia; Kidney; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; Mineralocorticoid Receptor Antagonists; Peptide Fragments; Potassium Channels, Inwardly Rectifying; Potassium, Dietary; Proton-Translocating ATPases; Rats, Sprague-Dawley; Receptors, Cell Surface; Renin; Renin-Angiotensin System; Signal Transduction; Solute Carrier Family 12, Member 3; Spironolactone; Vacuolar Proton-Translocating ATPases | 2017 |
Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7).
Topics: Aldosterone; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Eplerenone; HEK293 Cells; Humans; Immediate-Early Proteins; Protein Domains; Protein Serine-Threonine Kinases; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; TRPM Cation Channels; Up-Regulation | 2016 |
Mineralocorticoid Receptor Blockade Improves Insulin Sensitivity in the Rat Heart and a Possible Molecular Mechanism.
Topics: Adiponectin; Aldosterone; Animals; Animals, Newborn; Biological Transport; Eplerenone; Gene Expression Regulation; Glucose; Glucose Clamp Technique; Insulin; Insulin Resistance; Male; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; PPAR alpha; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger; Signal Transduction; Spironolactone | 2016 |
Effects of early aldosterone antagonism on cardiac remodeling in rats with aortic stenosis-induced pressure overload.
Topics: Aldosterone; Animals; Aortic Valve Stenosis; Cardiomegaly; Electrocardiography; Male; Mineralocorticoid Receptor Antagonists; Random Allocation; Rats; Rats, Wistar; Spironolactone; Treatment Outcome; Ventricular Remodeling | 2016 |
Corticosteroid and progesterone transactivation of mineralocorticoid receptors from Amur sturgeon and tropical gar.
Topics: Aldosterone; Animals; Corticosterone; Cortodoxone; Desoxycorticosterone; Fish Proteins; Fishes; Humans; Hydrocortisone; Phylogeny; Progesterone; Receptors, Mineralocorticoid; Spironolactone; Transcriptional Activation | 2016 |
Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.
Topics: Adrenal Glands; Aldosterone; Animals; Blood Glucose; Body Weight; Cytochrome P-450 CYP11B2; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Evaluation, Preclinical; Eating; Eplerenone; Fadrozole; Glucose Tolerance Test; Glycated Hemoglobin; Insulin; Insulin Resistance; Insulin Secretion; Liver; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Potassium; Random Allocation; Rats, Zucker; Sodium; Spironolactone; Triglycerides | 2016 |
The Clinical Value of Salivary Aldosterone in Diagnosis and Follow-Up of Primary Aldosteronism.
Topics: Adrenalectomy; Aged; Aldosterone; Case-Control Studies; Circadian Rhythm; Eplerenone; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Prognosis; Prospective Studies; Retrospective Studies; Saliva; Spironolactone | 2016 |
Effects of Treating Primary Aldosteronism on Renal Function.
Topics: Adrenalectomy; Adult; Aldosterone; Female; Glomerular Filtration Rate; Humans; Hyperaldosteronism; Male; Middle Aged; Renal Insufficiency, Chronic; Renin; Retrospective Studies; Spironolactone | 2017 |
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.
Topics: Adipose Tissue; Adolescent; Adult; Aged; Aldehyde Reductase; Aldosterone; Animals; Blood Glucose; Caveolin 1; Cholesterol; Dyslipidemias; Eplerenone; Female; Gene Frequency; Glucose; Homeostasis; Humans; Hypertriglyceridemia; Insulin; Insulin Resistance; Lipid Metabolism; Lipoproteins, HDL; Liver; Male; Mice; Mice, Knockout; Middle Aged; Mineralocorticoid Receptor Antagonists; NADPH Oxidase 4; Polymorphism, Single Nucleotide; Receptors, Mineralocorticoid; Resistin; Retinol-Binding Proteins, Plasma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spironolactone; Triglycerides; Young Adult | 2016 |
Pathophysiological aldosterone levels modify the secretory activity of cardiac progenitor cells.
Topics: Aldosterone; Animals; Cell Movement; Cell Proliferation; Cytokines; Eplerenone; Mice; Mineralocorticoid Receptor Antagonists; Myocardium; Proteome; Reproducibility of Results; Spironolactone; Stem Cells | 2017 |
Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism?
Topics: Aldosterone; Cytochrome P-450 CYP11B2; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2017 |
Aldosterone induces rapid sodium intake by a nongenomic mechanism in the nucleus tractus solitarius.
Topics: Aldosterone; Animals; Dose-Response Relationship, Drug; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, G-Protein-Coupled; Receptors, Mineralocorticoid; Sodium; Sodium Chloride; Solitary Nucleus; Spironolactone | 2016 |
The role of spironolactone on myocardial oxidative stress in rat model of streptozotocin-induced diabetes.
Topics: Aldosterone; Animals; Blood Pressure; Catalase; Cytochrome P-450 CYP11B2; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nitrites; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Spironolactone; Streptozocin; Superoxide Dismutase; Time Factors; Tyrosine; Vitamin E | 2017 |
Mineralocorticoid Receptor Blockade for Prevention of Acute Kidney Injury: An Elusive Target.
Topics: Acute Kidney Injury; Aldosterone; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2017 |
Monitoring renal safety in mineralocorticoid receptor antagonist trials.
Topics: Aldosterone; Heart Failure; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone | 2017 |
The Inhibitory Effect of Eplerenone on Cell Proliferation in the Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction.
Topics: Actins; Aldosterone; Animals; Cell Proliferation; Collagen; Eplerenone; Fibrosis; Immediate-Early Proteins; Kidney; Male; MAP Kinase Signaling System; Mineralocorticoid Receptor Antagonists; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spironolactone; Tumor Necrosis Factor-alpha; Up-Regulation; Ureteral Obstruction | 2017 |
Gene expression effects of glucocorticoid and mineralocorticoid receptor agonists and antagonists on normal human skeletal muscle.
Topics: Adolescent; Adult; Aldosterone; Blotting, Western; Cells, Cultured; Eplerenone; Humans; Male; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Prednisolone; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Young Adult | 2017 |
Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats.
Topics: Aldosterone; Animals; Claudin-4; Claudins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Hyperglycemia; Immediate-Early Proteins; Kidney Glomerulus; Kidney Tubules; Models, Biological; Natriuresis; Nephrons; Oxidative Stress; Phosphorylation; Potassium; Protein Serine-Threonine Kinases; Proteinuria; Rats, Wistar; Signal Transduction; Spironolactone; Tight Junctions; Weight Loss | 2017 |
Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells.
Topics: Adrenalectomy; Aldosterone; Aorta; Coronary Vessels; Cytochrome P-450 CYP11B2; Gene Expression Regulation; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteogenesis; Phosphates; Receptors, Mineralocorticoid; Spironolactone; Vascular Calcification | 2017 |
Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Biomarkers; Blood Pressure; Cardiovascular Diseases; Chronic Kidney Disease-Mineral and Bone Disorder; Echocardiography; Female; Fibrosis; Humans; Inflammation; Interleukin-6; Male; Matrix Metalloproteinase 2; Middle Aged; Mineralocorticoid Receptor Antagonists; Osteopontin; P-Selectin; Parathyroid Hormone; Peritoneal Dialysis; Pulse Wave Analysis; Renal Insufficiency, Chronic; Spironolactone; Thrombosis; Transforming Growth Factor beta; Vascular Stiffness | 2017 |
Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload.
Topics: Aldosterone; Animals; Biomarkers; Blood Pressure; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibrosis; Gene Expression Regulation; Gene Knockout Techniques; Glucuronidase; Klotho Proteins; Mice; Mice, Knockout; Signal Transduction; Spironolactone | 2017 |
Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma.
Topics: ACTH-Secreting Pituitary Adenoma; Aldosterone; Animals; Antihypertensive Agents; Aorta; Cell Proliferation; Collagen; Disease Models, Animal; Eplerenone; Hydralazine; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-mdm2; Random Allocation; Rats, Sprague-Dawley; Spironolactone; Transforming Growth Factor beta; Vascular Remodeling; Vasodilator Agents | 2018 |
Double hit! A unique case of resistant hypertension.
Topics: Adrenal Glands; Aldosterone; Diuretics; Female; Humans; Hyperaldosteronism; Hyperparathyroidism, Primary; Hypertension; Middle Aged; Spironolactone; Thyroidectomy; Tomography, X-Ray Computed | 2017 |
Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes.
Topics: Aldosterone; Animals; beta Catenin; Disease Models, Animal; Down-Regulation; Eplerenone; Glomerulonephritis; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Kidney Cortex; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Obesity; Podocytes; Sialoglycoproteins; Spironolactone; Wnt Proteins; Wnt Signaling Pathway | 2018 |
Subclinical target organ damage in primary aldosteronism: resistant to spironolactone therapy?
Topics: Aldosterone; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 2018 |
Pannexin Channel Inhibition: An Evolving Target to Lower Blood Pressure?
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Mineralocorticoid Receptor Antagonists; Spironolactone | 2018 |
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
Topics: Administration, Oral; Aldosterone; Animals; Benzoates; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eplerenone; Humans; Kidney; Male; Mice, Mutant Strains; Mineralocorticoid Receptor Antagonists; Molecular Structure; Oxazines; Potassium; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renal Insufficiency, Chronic; Sodium; Sodium, Dietary; Spironolactone | 2018 |
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
Topics: Aldosterone; Amiloride; Antihypertensive Agents; Bisoprolol; Blood Pressure; Doxazosin; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Spironolactone | 2018 |
Fluid retention, aldosterone excess, and treatment of resistant hypertension.
Topics: Aldosterone; Amiloride; Blood Pressure; Hemodynamics; Humans; Hypertension; Spironolactone | 2018 |
Licorice-induced apparent mineralocorticoid excess compounded by excessive use of terbutaline and high water intake.
Topics: Aldosterone; Asthma; Bronchodilator Agents; Diagnosis, Differential; Glycyrrhiza; Humans; Hypertension; Hypokalemia; Male; Medical History Taking; Middle Aged; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Potassium; Renin; Spironolactone; Terbutaline; Treatment Outcome | 2018 |
Maximizing benefits and mitigating risks with mineralocorticoid receptor antagonist therapy.
Topics: Aldosterone; Heart Failure; Humans; Hyperkalemia; Incidence; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2018 |
Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Antigens, Tumor-Associated, Carbohydrate; Aorta; Bleeding Time; Blood Pressure; Carboxypeptidase B2; Collagen; Drug Therapy, Combination; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Platelet Adhesiveness; Quinapril; Rats, Wistar; Renin; Spironolactone; Tetrahydroisoquinolines; Tissue Plasminogen Activator; Venous Thrombosis | 2018 |
An uncommon cause of leg oedema.
Topics: Aged; Aldosterone; Edema; Female; Humans; Hyperaldosteronism; Hypokalemia; Leg; Magnetic Resonance Imaging; Mineralocorticoid Receptor Antagonists; Renin; Spironolactone | 2019 |
Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes.
Topics: Albuminuria; Aldosterone; Angiotensin-Converting Enzyme 2; Animals; Autophagy; Beclin-1; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microtubule-Associated Proteins; Mineralocorticoid Receptor Antagonists; Peptidyl-Dipeptidase A; Podocytes; Renin-Angiotensin System; Spironolactone; WT1 Proteins | 2019 |
Aldosterone stimulation mediates cardiac metabolism remodeling via Sirt1/AMPK signaling in canine model.
Topics: Aldosterone; AMP-Activated Protein Kinases; Animals; Apoptosis; Dogs; Electrocardiography; Heart Ventricles; Male; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Signal Transduction; Sirtuin 1; Spironolactone; Ventricular Remodeling | 2019 |
Adrenocortical hypofunction with simultaneous primary aldosteronism: A case report.
Topics: Adrenal Insufficiency; Aged; Aldosterone; Cushing Syndrome; Female; Humans; Hydrocortisone; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone | 2019 |
Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1-7)/MAS receptor axes in human mesangial cells.
Topics: Aldosterone; Angiotensin I; Angiotensin-Converting Enzyme 2; Cells, Cultured; Glycosylation; Humans; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Spironolactone; Vesicular Transport Proteins | 2019 |
Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist.
Topics: Aldosterone; Amino Acid Substitution; Animals; Evolution, Molecular; Homeostasis; Humans; Leucine; Ligands; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Progesterone; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Receptors, Mineralocorticoid; Rodentia; Serine; Spironolactone; Structure-Activity Relationship; Threonine; Zebrafish | 2019 |
Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo.
Topics: Adult; Aged; Aldosterone; Eplerenone; Female; Hair; Humans; Middle Aged; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2019 |
A rare cause of hypertension in childhood: Answers.
Topics: Aldosterone; Alkalosis; Bartter Syndrome; Child; Child, Preschool; Consanguinity; Cortisone; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Hydrocortisone; Hypertension; Hypokalemia; Infant; Male; Mineralocorticoid Excess Syndrome, Apparent; Potassium; Renin; Spironolactone | 2020 |
Spironolactone suppresses aldosterone-induced Kv1.5 expression by attenuating mineralocorticoid receptor-Nox1/2/4-mediated ROS generation in neonatal rat atrial myocytes.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Heart Atria; Kv1.5 Potassium Channel; Myocytes, Cardiac; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidase 4; Pyrazoles; Pyrazolones; Pyridines; Pyridones; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spironolactone | 2019 |
Aldosterone: The Missing Cardiorenal Link.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Heart Diseases; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Renin-Angiotensin System; Risk Factors; Spironolactone; Water-Electrolyte Balance | 2019 |
The Impact of Spironolactone on Markers of Myocardial Oxidative Status, Inflammation and Remodeling in Hyperthyroid Rats.
Topics: Aldosterone; Animals; Antioxidants; Biomarkers; Blood Pressure; Body Weight; Cardiovascular Diseases; Endothelin-1; Heart; Heart Rate; Hyperthyroidism; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nitrites; Organ Size; Oxidative Stress; Random Allocation; Rats; Spironolactone; Thyroid Hormones; Thyroxine; Transforming Growth Factor beta | 2020 |
[Aldosterone promotes migration of rat hepatic stellate cells via activation of RhoA/ROCK signaling pathway].
Topics: Aldosterone; Amides; Animals; Cell Movement; Cells, Cultured; Hepatic Stellate Cells; Pyridines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Spironolactone | 2019 |
Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.
Topics: Aldosterone; Angiotensins; Animals; Blood Pressure; Gene Knockout Techniques; Kidney Tubules, Distal; Kir5.1 Channel; Mineralocorticoid Receptor Antagonists; Potassium Channels, Inwardly Rectifying; Potassium, Dietary; Rats, Inbred Dahl; Renin-Angiotensin System; Sodium, Dietary; Spironolactone | 2019 |
Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation.
Topics: Aldosterone; Animals; Aquaporin 1; beta Catenin; Cell Proliferation; Disease Models, Animal; Female; Mineralocorticoid Receptor Antagonists; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spironolactone | 2020 |
Striatin heterozygous mice are more sensitive to aldosterone-induced injury.
Topics: Aldosterone; Animals; Blood Pressure; Calmodulin-Binding Proteins; Eplerenone; Kidney; Male; Membrane Proteins; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Pyrroles; Spironolactone; Sulfones | 2020 |
Mineralocorticoid Receptor Antagonists in ESKD.
Topics: Aldosterone; Cardiovascular Diseases; Eplerenone; Humans; Kidney Failure, Chronic; Mineralocorticoid Receptor Antagonists; Spironolactone | 2020 |
Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat.
Topics: Aldosterone; Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Hypertension; Kidney Diseases; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Transgenic; Spironolactone | 2020 |
Elevated Renin and Aldosterone Levels in a Young Woman With Hypertension.
Topics: Adult; Aldosterone; Androstenes; Antihypertensive Agents; Computed Tomography Angiography; Contraceptives, Oral, Hormonal; Diagnosis, Differential; Drug Combinations; Estradiol; Female; Humans; Hypertension; Patient Selection; Polycystic Ovary Syndrome; Renin; Renin-Angiotensin System; Spironolactone | 2020 |
Aldosterone Antagonism in Atrial Fibrillation: Implications for AF-Predominant HFpEF.
Topics: Aldosterone; Atrial Fibrillation; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Stroke Volume | 2020 |
Changes in Glucose Metabolism after Adrenalectomy or Treatment with a Mineralocorticoid Receptor Antagonist for Primary Aldosteronism.
Topics: Adrenalectomy; Adult; Aged; Aldosterone; Blood Glucose; Fasting; Female; Humans; Hyperaldosteronism; Insulin; Insulin Resistance; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Regression Analysis; Risk Factors; Spironolactone; Taiwan | 2020 |
Aldosterone: Behind the Scenes of Depression and Heart Failure?
Topics: Aldosterone; Depression; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Stroke Volume | 2020 |
Factors affecting the urinary aldosterone-to-creatinine ratio in healthy dogs and dogs with naturally occurring myxomatous mitral valve disease.
Topics: Aldosterone; Animals; Creatinine; Dog Diseases; Dogs; Female; Furosemide; Heart Valve Diseases; Male; Mitral Valve; Renin-Angiotensin System; Spironolactone | 2021 |
Antagonistic effects of finerenone and spironolactone on the aldosterone-regulated transcriptome of human kidney cells.
Topics: Aldosterone; Chromatin Immunoprecipitation; Humans; Kidney; Naphthyridines; Real-Time Polymerase Chain Reaction; RNA-Seq; Sequence Analysis, RNA; Spironolactone; Transcriptome | 2021 |
Endothelial mineralocorticoid receptor ablation confers protection towards endothelial dysfunction in experimental diabetes in mice.
Topics: Aldosterone; Animals; Diabetes Mellitus, Experimental; Mice; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2022 |
Novel Insights into the Role of the Mineralocorticoid Receptor in Human Glioblastoma.
Topics: Aldosterone; Cell Line, Tumor; Glioblastoma; Humans; Neoplastic Stem Cells; Receptors, Mineralocorticoid; Spironolactone | 2021 |
Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain.
Topics: Aldosterone; Animals; Corticosterone; Cortodoxone; Desoxycorticosterone; Dexamethasone; Eplerenone; Fish Proteins; Fishes; Gene Expression; Hydrocortisone; Kinetics; Progesterone; Protein Domains; Protein Engineering; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Triamcinolone | 2022 |
Aldosterone is a possible new stimulating factor for promoting vascular calcification.
Topics: Aldosterone; Animals; Aorta; Rats; Renin-Angiotensin System; Spironolactone; Vascular Calcification | 2021 |
Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
Topics: Aldosterone; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mineralocorticoid Receptor Antagonists; Neoplasm Proteins; Rats; Rats, Inbred WKY; Receptors, Mineralocorticoid; Spironolactone; Water-Electrolyte Balance; Weight Loss | 2022 |
Apparent mineralocorticoid excess: A diagnosis beyond classical causes of severe hypertension in a child.
Topics: Aldosterone; Amiloride; Blood Pressure; Child, Preschool; Female; Humans; Hypertension; Hypokalemia; Mineralocorticoid Excess Syndrome, Apparent; Renin; Spironolactone | 2022 |
Non-steroidal aldosterone receptor antagonism: a 'fine' treatment for heart failure patients?
Topics: Aldosterone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Spironolactone | 2022 |
A quantitative systems pharmacology model of plasma potassium regulation by the kidney and aldosterone.
Topics: Aldosterone; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Network Pharmacology; Potassium; Spironolactone | 2022 |
[Three ages of spironolactone. Evolution of views on spironolactone capabilities in the treatment of patients with heart failure.]
Topics: Aldosterone; Female; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Water | 2022 |
Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance.
Topics: Aldosterone; Animals; CD36 Antigens; Diet, High-Fat; Dietary Fats; Dietary Sugars; Fatty Acids, Nonesterified; Glucose Transport Proteins, Facilitative; Insulin; Insulin Resistance; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Skeletal; Palmitic Acid; Receptors, Mineralocorticoid; Spironolactone | 2022 |
[New clinical opportunities for mineralocorticoid receptor antagonists: focus on antifibrotic effects].
Topics: Aldosterone; COVID-19 Drug Treatment; Eplerenone; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; SARS-CoV-2; Spironolactone | 2021 |
Effect of Metabolic Adaptation by Voluntary Running Wheel Activity and Aldosterone Inhibition on Renal Function in Female Spontaneously Hypertensive Rats.
Topics: Aldosterone; Animals; Body Weight; Female; Hypertension; Kidney; Motor Activity; Proprotein Convertase 9; Rats; Rats, Inbred SHR; Rats, Wistar; RNA, Messenger; Spironolactone | 2022 |
Unique Case of Cardiomyopathy Secondary to Adrenal Adenoma (Primary-Aldosteronism).
Topics: Adenoma; Adrenocortical Adenoma; Aldosterone; Cardiomyopathies; Female; Humans; Hyperaldosteronism; Hypertension; Hypertrophy, Left Ventricular; Spironolactone | 2023 |
Mineralocorticoid receptor blockade protects the kidneys but does not affect inverted blood pressure rhythm in hypertensive transgenic (mRen-2)27 rats.
Topics: Albuminuria; Aldosterone; Animals; Animals, Genetically Modified; Blood Pressure; Hypertension; Kidney; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Mineralocorticoid; Spironolactone; Water | 2023 |
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.
Topics: Aldosterone; Animals; Colon; Epithelial Sodium Channels; Gene Expression; Hypovolemia; Kidney; Liver Cirrhosis; Rats; Renal Insufficiency; Sodium; Spironolactone | 2023 |
Aldosterone Antagonism Is More Effective at Reducing Blood Pressure and Excessive Renal ENaC Activity in AngII-Infused Female Rats Than in Males.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Diuretics; Female; Hypertension; Hypotension; Male; Mice; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sodium; Spironolactone | 2023 |
Primary Aldosteronism.
Topics: Aldosterone; Humans; Hyperaldosteronism; Hypertension; Renin; Spironolactone | 2023 |
Who and How Should We Screen for Primary Aldosteronism?
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Humans; Hyperaldosteronism; Hypertension; Renin; Spironolactone | 2023 |
Increasing rates of referrals for investigation of primary aldosteronism at a tertiary centre.
Topics: Adrenalectomy; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists; New Zealand; Referral and Consultation; Renin; Retrospective Studies; Spironolactone | 2023 |