Page last updated: 2024-08-17

aldosterone and sirolimus

aldosterone has been researched along with sirolimus in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (25.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80

Authors

Authors	Studies
Djurhuus, JC; Golbaekdal, K; Nielsen, CB; Pedersen, EB	1
Johnson, JP; Palevsky, PM; Rokaw, MD; West, ME	1
Boldyreff, B; Braun, S; Lösel, R; Wehling, M	1
Mansley, MK; Wilson, SM	1
Gu, Y; Huang, B; Jin, X; Li, F; Ning, G; Su, H; Sun, F; Wang, Q	1
Ding, W; Gu, Y; Li, H; Wang, B; Zhang, M	1
Betz, MJ; Beuschlein, F; Burkard, T; Cavelti-Weder, C; Donath, MY; Hall, MN; Hepprich, M; Kratschmar, DV; Meienberg, F; Odermatt, A; Reincke, M; Seelig, E; Swierczynska, MM; Trinh, B	1
Ali, Y; Gomez-Sanchez, CE; Gomez-Sanchez, EP	1

Trials

1 trial(s) available for aldosterone and sirolimus

Article	Year
Treatment of Primary Aldosteronism With mTORC1 Inhibitors. The Journal of clinical endocrinology and metabolism, 2019, 10-01, Volume: 104, Issue:10 Topics: Adult; Aldosterone; Angiotensin II; Animals; Blood Pressure; Everolimus; Female; Hemodynamics; Humans; Hyperaldosteronism; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Pilot Projects; Proof of Concept Study; Renin; Sirolimus	2019

Article

Year

Treatment of Primary Aldosteronism With mTORC1 Inhibitors.

The Journal of clinical endocrinology and metabolism, 2019, 10-01, Volume: 104, Issue:10

Topics: Adult; Aldosterone; Angiotensin II; Animals; Blood Pressure; Everolimus; Female; Hemodynamics; Humans; Hyperaldosteronism; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Pilot Projects; Proof of Concept Study; Renin; Sirolimus

2019

Other Studies

7 other study(ies) available for aldosterone and sirolimus

Article	Year
Effects of rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin in pigs. Transplantation, 1994, Dec-15, Volume: 58, Issue:11 Topics: Aldosterone; Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Diuresis; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Immunosuppressive Agents; Kidney; Lithium; Natriuresis; Polyenes; Renal Circulation; Sirolimus; Swine; Vasopressins	1994
FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 1 Topics: Aldosterone; Biological Transport; Cell Line; Cyclosporine; Electric Conductivity; Immunosuppressive Agents; Mineralocorticoid Receptor Antagonists; Nystatin; Polyenes; Sirolimus; Sodium; Tacrolimus; Time Factors	1996
Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84. FEBS letters, 2004, Jul-16, Volume: 570, Issue:1-3 Topics: Aldosterone; Animals; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Kidney; Mice; Phosphorylation; Precipitin Tests; Receptors, Mineralocorticoid; Sirolimus; Spironolactone; src-Family Kinases; Time Factors; Tyrosine	2004
Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2. British journal of pharmacology, 2010, Volume: 161, Issue:8 Topics: Absorption; Aldosterone; Animals; Arginine Vasopressin; Cells, Cultured; Dexamethasone; Epithelial Cells; Immediate-Early Proteins; Insulin; Kidney Tubules, Collecting; Membrane Potentials; Mice; Naphthyridines; Phosphorylation; Protein Serine-Threonine Kinases; Sirolimus; Sodium; TOR Serine-Threonine Kinases	2010
The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism. PloS one, 2013, Volume: 8, Issue:4 Topics: Adrenal Glands; Adult; Aldosterone; Cell Line; Cell Proliferation; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2013
Rapamycin attenuates aldosterone-induced tubulointerstitial inflammation and fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:1 Topics: Aldosterone; Animals; Antibiotics, Antineoplastic; Cell Line; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibrosis; Humans; Male; Nephritis, Interstitial; Phosphorylation; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Up-Regulation	2015
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells. Endocrinology, 2022, 11-14, Volume: 164, Issue:1 Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aldosterone; Angiotensin II; Humans; Hydrocortisone; RNA, Guide, Kinetoplastida; Sirolimus; TOR Serine-Threonine Kinases	2022