Page last updated: 2024-08-17

aldosterone and osilodrostat

aldosterone has been researched along with osilodrostat in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	8 (88.89)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Amar, L; Azizi, M; Menard, J; Peyrard, S; Plouin, PF; Watson, C	1
Andersen, K; Hartman, D; Hermann, D; Lefkowitz, M; Peppard, T; Trapani, A; Van Ess, P	1
Amar, L; Azizi, M; Menard, J	1
Brown, NJ	1
Brunner, HR; Schumacher, CD; Steele, RE	1
Adams, CM; Amaral, A; Beil, ME; Carvalho, J; Fu, F; Gangl, E; Hu, CW; Hu, QY; Jeng, AY; Ksander, GM; LaSala, D; Liang, G; Logman, M; Lou, C; Maniara, WM; Papillon, JP; Rajan, S; Rigel, DF; Singh, AK; Smith, SA; Zhang, C	1
Bernhardt, R	1
Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM	1
Auchus, RJ; Liu, J; Oommen, J; Peng, HM; Valentín-Goyco, J	1

Reviews

3 review(s) available for aldosterone and osilodrostat

Article	Year
Aldosterone synthase inhibition in humans. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:1 Topics: Aldosterone; Antihypertensive Agents; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Humans; Hypertension; Imidazoles; Pyridines; Steroid 11-beta-Hydroxylase	2013
Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nature reviews. Nephrology, 2013, Volume: 9, Issue:8 Topics: Aldosterone; Animals; Aromatase Inhibitors; Cardiovascular System; Cytochrome P-450 CYP11B2; Endothelial Cells; Fadrozole; Fibrosis; Humans; Imidazoles; Inflammation; Kidney; Macrophages; Mineralocorticoid Receptor Antagonists; Myocardium; Myocytes, Cardiac; Pyridines; Reactive Oxygen Species; Receptors, Mineralocorticoid; Sodium, Dietary	2013
The potential of targeting CYP11B. Expert opinion on therapeutic targets, 2016, Volume: 20, Issue:8 Topics: Aldosterone; Animals; Cardiomegaly; Cytochrome P-450 CYP11B2; Drug Design; Humans; Hypertension; Imidazoles; Isoenzymes; Kidney Diseases; Molecular Targeted Therapy; Pyridines; Steroid 11-beta-Hydroxylase	2016

Trials

3 trial(s) available for aldosterone and osilodrostat

Article	Year
Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:5 Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Blood Pressure; Cytochrome P-450 CYP11B2; Female; Humans; Hydrocortisone; Hyperaldosteronism; Imidazoles; Intention to Treat Analysis; Male; Middle Aged; Potassium; Pyridines; Renin	2010
The effects of aldosterone synthase inhibition on aldosterone and cortisol in patients with hypertension: a phase II, randomized, double-blind, placebo-controlled, multicenter study. Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:9 Topics: Adolescent; Adult; Aged; Aldosterone; Arterial Pressure; Cytochrome P-450 CYP11B2; Double-Blind Method; Female; Humans; Hydrocortisone; Hypertension; Imidazoles; Male; Middle Aged; Prospective Studies; Pyridines; Renin-Angiotensin System; Young Adult	2012
Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy. Journal of hypertension, 2013, Volume: 31, Issue:10 Topics: Adolescent; Adrenal Glands; Adult; Aged; Aldosterone; Antihypertensive Agents; Biomarkers; Blood Pressure; Cytochrome P-450 CYP11B2; Desoxycorticosterone; Double-Blind Method; Essential Hypertension; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypothalamus; Imidazoles; Male; Middle Aged; Prospective Studies; Pyridines; Renin-Angiotensin System; Steroid 11-beta-Hydroxylase; Treatment Outcome; Young Adult	2013

Other Studies

3 other study(ies) available for aldosterone and osilodrostat

Article	Year
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors. Journal of medicinal chemistry, 2015, Jun-11, Volume: 58, Issue:11 Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Corticosterone; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Imidazoles; Male; Microsomes, Liver; Models, Molecular; Molecular Structure; Pyridines; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship; Tissue Distribution	2015
Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study. The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8 Topics: Aldosterone; Cell Culture Techniques; Cortodoxone; Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Metyrapone; Pyridines; Steroid 11-beta-Hydroxylase	2019
Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450. The Journal of steroid biochemistry and molecular biology, 2023, Volume: 231 Topics: Aldosterone; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 CYP11B2; HEK293 Cells; Humans; Pituitary ACTH Hypersecretion; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase	2023