aldisine and hydrazine

aldisine has been researched along with hydrazine* in 1 studies

Other Studies

1 other study(ies) available for aldisine and hydrazine

ArticleYear
Design, Synthesis, and Bioactivity of Aldisine Derivatives Containing Oxime and Hydrazine Moieties Based on Hydrogen Bonds.
    Journal of agricultural and food chemistry, 2023, Jul-26, Volume: 71, Issue:29

    Marine natural products have attracted more and more attention in drug research and development due to their unique structure, diverse biological activities, and novel mode of action. Using antiviral alkaloid aldisine as the lead compound and drawing on the hydrogen bond effect widely used in drug design, derivatives containing oxime and hydrazone moieties were designed and synthesized by introducing functional groups with hydrogen-bond receptors or donors into molecules. The configuration of derivatives was systematically studied through nuclear Overhauser effect (NOE) spectroscopy and single crystal analysis. The antiviral activity test result showed that most derivatives had antiviral activity against tobacco mosaic virus (TMV), and some compounds had better activity than the commercial antiviral drug ribavirin, especially compounds

    Topics: Antiviral Agents; Drug Design; Hydrazines; Hydrazones; Hydrogen Bonding; Molecular Docking Simulation; Molecular Structure; Oximes; Structure-Activity Relationship; Tobacco Mosaic Virus

2023