alchivemycin-a and equisetin

Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a (1)H NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.

Topics: Drug Screening Assays, Antitumor; Fatty Alcohols; Macrolides; Microbial Sensitivity Tests; Micrococcus luteus; Molecular Structure; Neoplasm Invasiveness; Pyrrolidinones; Streptomyces; Tetrahydronaphthalenes