albonoursin and phenylahistin

albonoursin has been researched along with phenylahistin* in 1 studies

Other Studies

1 other study(ies) available for albonoursin and phenylahistin

Article	Year
A novel potent cell cycle inhibitor dehydrophenylahistin--enzymatic synthesis and inhibitory activity toward sea urchin embryo. The Journal of antibiotics, 2002, Volume: 55, Issue:12 A novel dehydrogenated cyclic dipeptide named as dehydrophenylahistin (deltaPLH) was effectively prepared from a fungal metabolite (-)-phenylahistin by the enzymatic conversion catalyzed by the cell-free extract of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. deltaPLH exhibited more than 1,000 times as high potent inhibitory activity toward the first cleavage of sea urchin embryos as (-)-phenylahisitn which has been reported to be a cell cycle inhibitor and more than 10,000 as high as albonoursin, indicating that deltaPLH is a promising leading compound for anticancer drugs. Topics: Animals; Cell Cycle; Chromatography, High Pressure Liquid; Diketopiperazines; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Enzymes; Inhibitory Concentration 50; Isomerism; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides, Cyclic; Piperazines; Sea Urchins; Streptomyces	2002

Article

Year

A novel potent cell cycle inhibitor dehydrophenylahistin--enzymatic synthesis and inhibitory activity toward sea urchin embryo.

The Journal of antibiotics, 2002, Volume: 55, Issue:12

A novel dehydrogenated cyclic dipeptide named as dehydrophenylahistin (deltaPLH) was effectively prepared from a fungal metabolite (-)-phenylahistin by the enzymatic conversion catalyzed by the cell-free extract of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. deltaPLH exhibited more than 1,000 times as high potent inhibitory activity toward the first cleavage of sea urchin embryos as (-)-phenylahisitn which has been reported to be a cell cycle inhibitor and more than 10,000 as high as albonoursin, indicating that deltaPLH is a promising leading compound for anticancer drugs.

Topics: Animals; Cell Cycle; Chromatography, High Pressure Liquid; Diketopiperazines; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Enzymes; Inhibitory Concentration 50; Isomerism; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides, Cyclic; Piperazines; Sea Urchins; Streptomyces

2002