albiflorin and benzoylpaeoniflorin

albiflorin has been researched along with benzoylpaeoniflorin* in 6 studies

Other Studies

6 other study(ies) available for albiflorin and benzoylpaeoniflorin

ArticleYear
[Preparation and Synchronized Release Behavior on Porosity Osmotic Pump Tablets of Total Glucosides of Paeony].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:2

    To prepare porosity osmotic pump tablets of total glucosides of paeony( TGP),and to study the behavior on synchronous release of its main components.. Taking the accumulative release of TGP as indexes, through single-factor test and orthogonal design to investigate the optimal formulation porosity osmotic pump tablets of TGP. The main components, paeoniflorin, albiflorin and benzoylpaeoniflorin were employed to study synchronous release of the optimal formulation.. The membrane weight, and the content of PEG 400,and diethyl phthalate( DEP) were the main factors influencing the behavior of TGP release. The accumulated release of the prepared osmotic pump release tablets achieved about 90%. Three main components achieved the desired zero-order release profile and had a synchronized release behavior.. The prepared porosity osmotic pump tablets of TGP can achieve the behavior of synchronized release of multi-components with good reproducibility.

    Topics: Bridged-Ring Compounds; Delayed-Action Preparations; Glucosides; Monoterpenes; Osmosis; Paeonia; Polyethylene Glycols; Porosity; Reproducibility of Results; Solubility; Tablets

2016
Characterization and quantification of monoterpenoids in different types of peony root and the related Paeonia species by liquid chromatography coupled with ion trap and time-of-flight mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2016, Sep-10, Volume: 129

    Monoterpenoids with "cage-like" pinane skeleton are the unique and main bioactive constituents in peony root, the root of Paeonia lactiflora. A liquid chromatography coupled with ion trap and time-of-flight mass spectrometry (LC-IT-TOF-MS) method was developed for characterization and quantification of monoterpenoids in different types of peony root and the roots of related Paeonia species. MS/MS fragmentation patterns of monoterpenoids with paeoniflorin-, albiflorin- and sulfonated paeoniflorin-type of skeletons were elucidated, which provided basic clues enabling subsequent identification of 35 monoterpenoids in LC-MS profiles of Paeonia species. The profiling analysis and further quantification of 15 main monoterpenoids in 56 samples belonged to red peony root (RPR), white peony root (WPR), peony root in Japanese market (PR) and the roots of related Paeonia species revealed that paeoniflorin, benzoylpaeoniflorin, galloylpaeoniflorin, oxypaoniflorin and albiflorin were predominant constituents in all the samples; mudanpioside C was the characteristic component of P. lactiflora, and 4-O-methyl-paeoniflorin was only detected in P. veitchii and P. anomala. Total contents of the 15 monoterpenoids were obviously higher in the roots of P. lactiflora and P. veitchii than in those of P. anomala and P. japonica. Principal component analysis based on the quantitative results showed that the samples derived from P. lactiflora were clearly classified into RPR, WPR/PR, and sulfur-fumigated WPR groups, besides the respective group of P. veitchii and P. anomala. This study clarified the chemical characteristics of the respective type of peony root and the related Paeonia species, as well as the marker constituents for their discrimination.

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Glucosides; Monoterpenes; Paeonia; Plant Roots; Tandem Mass Spectrometry

2016
Elution-extrusion counter-current chromatography for the separation of two pairs of isomeric monoterpenes from Paeoniae Alba Radix.
    Journal of separation science, 2015, Volume: 38, Issue:17

    In this work, a simple and efficient protocol for the rapid separation of two pairs of isomeric monoterpenes from Paeoniae Alba Radix was developed by combining macroporous resin and elution-extrusion counter-current chromatography. The crude extract was firstly subjected to a D101 macroporous resin column eluted with water and a series of different concentrations of ethanol. Then, effluents of 30 and 95% ethanol were collected as sample 1 and sample 2 for further counter-current chromatography purification. Finally, a pair of isomers, 96 mg of compound 1 and 48 mg of compound 2 with purities of 91.1 and 96.2%, respectively, was isolated from 200 mg of sample 1. The other pair of isomers, 14 mg of compound 3 and 8 mg of compound 4 with purities of 93.6 and 88.9%, respectively, was isolated from 48 mg of sample 2. Their purities were analyzed by high-performance liquid chromatography, and their chemical structures were identified by mass spectrometry and (1) H NMR spectroscopy. Compared to a normal counter-current chromatography separation, the separation time and solvent consumption of elution-extrusion counter-current chromatography were reduced while the resolutions were still good. The established protocol is promising for the separation of natural products with great disparity of content in herbal medicines.

    Topics: Bridged-Ring Compounds; Chromatography; Chromatography, High Pressure Liquid; Countercurrent Distribution; Ethanol; Glucosides; Glycosides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Monoterpenes; Paeonia; Plant Preparations; Solvents; Ultrasonography

2015
Three new monoterpene glycosides from the roots of Paeonia lactiflora.
    Journal of Asian natural products research, 2013, Volume: 15, Issue:7

    Three new monoterpene glycosides, 2'-O-benzoylpaeoniflorin, albiflorin R2, and albiflorin R3 (1-3) were isolated from the roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic means including one- and two-dimensional NMR experiments.

    Topics: Bridged-Ring Compounds; Drugs, Chinese Herbal; Glucosides; Glycosides; Molecular Structure; Monoterpenes; Nuclear Magnetic Resonance, Biomolecular; Paeonia; Plant Roots

2013
Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix.
    Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2

    A complex formula composed of Paeonia lactiflora PALL. and Glycyrrhiza uralensis Fisch., which is called as Jakyak-Gamcho Decoction (JGD), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. In this study, the anti-inflammatory activity of JGD was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. Our results suggest that the three parameters are all crucial factors. The optimized conditions for extraction were therefore established [solvent (water); pH value (4); extraction number (4)]. We also optimized the extraction conditions related to anti-inflammatory activity [solvent (70% EtOH); pH value (6); extraction number (4)]. So, we found that the bioactivity was responsible for mixed components but not individual one. It was proportionally associated with the amounts of some components in the extracts of herbal medicines. When the proportion of the active components was similar to each other, they had the similar functions. Furthermore, the results could establish a model system for the quality assurance of herbal preparations, and provided a new paradigm of active components-pharmacodynamics, which is used for illustrating the connections between the bioactivities and the proportion of active constituents in the extracts of herbal medicines.

    Topics: Alkaline Phosphatase; Animals; Benzoates; Bridged-Ring Compounds; Cell Line; Cell Survival; Chalcone; Chemical Fractionation; Chromatography, High Pressure Liquid; Ethanol; Flavanones; Glucosides; Glycyrrhiza; Glycyrrhizic Acid; Herbal Medicine; Lipopolysaccharides; Macrophages; Monoterpenes; NF-kappa B; Nitric Oxide; Paeonia; Plant Extracts; Research Design; Solubility; Technology, Pharmaceutical; Water

2007
A new monoterpene glycoside from the roots of Paeonia lactiflora increases the differentiation of osteoblastic MC3T3-E1 cells.
    Archives of pharmacal research, 2007, Volume: 30, Issue:10

    A new monoterpene glycoside, 6'-O-beta-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6'-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia lactiflora Pall.. Their chemical structures were completely elucidated using a combination of 2D NMR techniques (COSY, HMQC and HMBC) and HRESI-MS analyses. To investigate the bioactivities of these compounds, their effects on the differentiation of osteoblastic MC3T3-E1 cells were tested. Compound 1 (0.01-10 microM) significantly increased the alkaline phosphatase activity and nodules mineralization of MC3T3-E1 cells compared to those of the control (P<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis.

    Topics: Alkaline Phosphatase; Animals; Benzoates; Bone Density Conservation Agents; Bridged-Ring Compounds; Calcification, Physiologic; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Glucosides; Glycosides; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Monoterpenes; Osteoblasts; Paeonia; Plant Extracts; Plant Roots; Spectrometry, Mass, Electrospray Ionization; Vietnam

2007