albicidin and 3-cyanoalanine

Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.

Topics: 4-Aminobenzoic Acid; Alanine; Anti-Bacterial Agents; Bacteria; Fermentation; Microbial Sensitivity Tests; Oligopeptides; Organic Chemicals; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xanthomonas

Topics: 4-Aminobenzoic Acid; Alanine; Anti-Bacterial Agents; Organic Chemicals; Topoisomerase II Inhibitors; Xanthomonas