alaproclate and zimeldine

alaproclate has been researched along with zimeldine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199025 (89.29)18.7374
1990's1 (3.57)18.2507
2000's0 (0.00)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Högberg, T; Renyi, AL; Ross, SB; Ulff, B1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Eneroth, P; Ross, SB; Syvälahti, E1
Sommerfelt, L; Ursin, R2
Brodin, E; Ogren, SO; Theodorsson-Norheim, E1
Bjorvatn, B; Sommerfelt, L; Underland, G; Ursin, R1
Horn, AM; Watts, AG1
Aberg-Wistedt, A; Alvariza, M; Bertilsson, L; Malmgren, R; Wachtmeister, H1
Aberg-Wistedt, A; Asberg, M; Bertilsson, L; Mårtensson, B; Montero, D; Wägner, A1
Bartfai, T; Iverfeldt, K; Ogren, SO1
Fuller, RW1
Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A1
Smith, DF1
Rényi, L1
Hauge, ER; Sommerfelt, L; Ursin, R1
Archer, T; Danysz, W; Hiltunen, AJ; Järbe, TU; Kostowski, W; Malatynska, E; Plaznik, A1
Eide, PK; Hole, K1
Ask, AL; Fowler, CJ; Hall, H; Kelder, D; Ross, SB; Sääf, J1
Fink, G; Horn, AM1
Hole, DR; Hunter, AJ; Wilson, CA1
Hall, H; Ross, SB1
Archer, T; Minor, BG; Ross, SB1
Archer, T; Johansson, G; Ogren, SO; Ross, SB1
Altman, HJ; Nordy, DA; Ogren, SO1
Hall, H; Ross, SB; Sällemark, M1
Holm, AC; Ogren, SO1

Reviews

3 review(s) available for alaproclate and zimeldine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Biochemical pharmacology of the serotonin system.
    Advances in neurology, 1986, Volume: 43

    Topics: Alanine; Brain; Citalopram; Clomipramine; Fenfluramine; Fluoxetine; Fluvoxamine; Humans; Monoamine Oxidase Inhibitors; Neurons; Oximes; p-Chloroamphetamine; Paroxetine; Piperidines; Propylamines; Receptors, Serotonin; Reserpine; Serotonin; Serotonin Antagonists; Synapses; Tetrabenazine; Zimeldine

1986
Therapeutic effects of serotonin uptake inhibitors in depression.
    The Journal of clinical psychiatry, 1986, Volume: 47 Suppl

    Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine

1986

Trials

2 trial(s) available for alaproclate and zimeldine

ArticleYear
Alaproclate a novel antidepressant? A biochemical and clinical comparison with zimeldine.
    Acta psychiatrica Scandinavica, 1985, Volume: 71, Issue:3

    Topics: Adult; Aged; Alanine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Serotonin; Serotonin Antagonists; Zimeldine

1985
Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder.
    Archives of general psychiatry, 1987, Volume: 44, Issue:10

    Topics: Adult; Aged; Alanine; Antidepressive Agents; Blood Platelets; Carrier Proteins; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Outcome and Process Assessment, Health Care; Psychiatric Status Rating Scales; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Zimeldine

1987

Other Studies

23 other study(ies) available for alaproclate and zimeldine

ArticleYear
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Animals; Biogenic Amines; Brain; Brompheniramine; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Mice; Molecular Conformation; Neurons; Norepinephrine; Pyridines; Serotonin; Structure-Activity Relationship; Zimeldine

1981
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Acute effects of zimelidine and alaproclate, two inhibitors of serotonin uptake, on neuroendocrine function.
    Psychiatry research, 1979, Volume: 1, Issue:2

    Topics: Adult; Alanine; Blood Platelets; Brompheniramine; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; In Vitro Techniques; Luteinizing Hormone; Male; Pituitary Hormones, Anterior; Prolactin; Pyridines; Serotonin; Serotonin Antagonists; Thyrotropin; Zimeldine

1979
Behavioral, sleep-waking and EEG power spectral effects following the two specific 5-HT uptake inhibitors zimeldine and alaproclate in cats.
    Behavioural brain research, 1991, Nov-26, Volume: 45, Issue:2

    Topics: Alanine; Animals; Behavior, Animal; Cats; Electroencephalography; Female; Hallucinations; Interpersonal Relations; Male; Motor Activity; Serotonin Antagonists; Sleep; Sleep Stages; Sleep, REM; Wakefulness; Zimeldine

1991
Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P- and neurokinin A/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat.
    Neuropharmacology, 1987, Volume: 26, Issue:6

    Topics: Alanine; Animals; Antidepressive Agents; Brain Chemistry; Central Nervous System; Imipramine; Immune Sera; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Zimeldine

1987
Increased waking as well as increased synchronization following administration of selective 5-HT uptake inhibitors to rats.
    Behavioural brain research, 1989, Aug-01, Volume: 34, Issue:1-2

    Topics: Alanine; Animals; Antidepressive Agents; Arousal; Brain; Cortical Synchronization; Dose-Response Relationship, Drug; Drinking; Eating; Electroencephalography; Evoked Potentials; Fenclonine; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Serotonin; Sleep Stages; Wakefulness; Zimeldine

1989
Effects of 5-hydroxytryptamine uptake blockers on the concentration in brain of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male rats, pro-oestrous rats and ovariectomized rats treated with oestrogen and progesterone.
    The Journal of endocrinology, 1985, Volume: 104, Issue:3

    Topics: Alanine; Animals; Brain; Castration; Estradiol; Female; Hydroxyindoleacetic Acid; Hypothalamus; Male; Pregnancy; Proestrus; Progesterone; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine

1985
Substance P receptors in the rat spinal cord: the effect of GTP and of chronic antidepressant treatment.
    Acta physiologica Scandinavica, 1988, Volume: 132, Issue:2

    Topics: Alanine; Animals; Antidepressive Agents; Guanosine Triphosphate; Imipramine; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Zimeldine

1988
The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.
    Neuroscience and biobehavioral reviews, 1986,Spring, Volume: 10, Issue:1

    Topics: Alanine; Amphetamine; Aniline Compounds; Animals; Antidepressive Agents; Blood Platelets; Brain; Fluoxetine; Humans; Male; Methadone; Mianserin; Mirtazapine; Morpholines; Naphthalenes; Nefopam; Nomifensine; Paroxetine; Piperidines; Rabbits; Serotonin; Stereoisomerism; Tranylcypromine; Viloxazine; Zimeldine

1986
The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat.
    British journal of pharmacology, 1986, Volume: 87, Issue:4

    Topics: Alanine; Animals; Behavior, Animal; Citalopram; Ejaculation; Fluoxetine; Male; Metergoline; Methoxydimethyltryptamines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Zimeldine

1986
Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats.
    Journal of neural transmission, 1987, Volume: 68, Issue:1-2

    Topics: Alanine; Animals; Brain; Cats; Electroencephalography; Female; Male; Neurotransmitter Uptake Inhibitors; Rats; Serotonin; Sleep Stages; Species Specificity; Zimeldine

1987
The effects of zimeldine and alaproclate combined with a small dose of 5-HTP on waking and sleep stages in cats.
    Behavioural brain research, 1987, Volume: 24, Issue:1

    Topics: 5-Hydroxytryptophan; Alanine; Animals; Cats; Drug Synergism; Electroencephalography; Female; Male; Sleep Stages; Sleep, REM; Wakefulness; Zimeldine

1987
Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs.
    Pharmacology & toxicology, 1988, Volume: 62, Issue:1

    Topics: Alanine; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Male; Rats; Rats, Inbred Strains; Time Factors; Zimeldine

1988
Acute and chronic treatment with selective serotonin uptake inhibitors in mice: effects on nociceptive sensitivity and response to 5-methoxy-N,N-dimethyltryptamine.
    Pain, 1988, Volume: 32, Issue:3

    Topics: Alanine; Animals; Biological Transport, Active; Clomipramine; Male; Methoxydimethyltryptamines; Mice; Nociceptors; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Zimeldine

1988
Cortical beta- and alpha 2- adrenoceptor binding, hypothalamic noradrenaline and pineal melatonin concentrations measured at different times of the day after repeated treatment of rats with imipramine, zimeldine, alaproclate and amiflamine.
    Acta pharmacologica et toxicologica, 1986, Volume: 58, Issue:1

    Topics: Alanine; Animals; Antidepressive Agents; Body Weight; Cerebral Cortex; Circadian Rhythm; Dihydroalprenolol; Hypothalamus; Imipramine; Kinetics; Male; Melatonin; Norepinephrine; Phenethylamines; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Zimeldine

1986
Effects of 5-hydroxytryptamine uptake blockers on the release of LH and prolactin in several different experimental steroid models in the rat.
    The Journal of endocrinology, 1985, Volume: 104, Issue:3

    Topics: Alanine; Animals; Castration; Estradiol; Female; Luteinizing Hormone; Pituitary Gland, Anterior; Pregnancy; Proestrus; Progesterone; Prolactin; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine

1985
Studies into the dual effects of serotonergic pharmacological agents on female sexual behaviour in the rat: preliminary evidence that endogenous 5HT is stimulatory.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:1

    Topics: 5-Hydroxytryptophan; Adrenalectomy; Alanine; Animals; Castration; Cinanserin; Female; Ketanserin; Metergoline; Methysergide; Mianserin; Piperidines; Progesterone; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Sexual Behavior, Animal; Zimeldine

1985
Maximal turnover number of the membranal serotonin carrier in rat brain synaptosomes in vitro.
    Acta physiologica Scandinavica, 1983, Volume: 118, Issue:2

    Topics: Alanine; Animals; Brain; Hydroxyindoleacetic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Synaptic Membranes; Zimeldine

1983
Attenuation of the post-decapitation convulsions after repeated treatment of rats with desipramine, imipramine and maprotiline.
    Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:5

    Topics: Alanine; Animals; Anticonvulsants; Antidepressive Agents; Desipramine; Imipramine; Male; Maprotiline; Rats; Rats, Inbred Strains; Time Factors; Zimeldine

1984
The effect of acute zimeldine and alaproclate administration on the acquisition of two-way active avoidance: comparison with other antidepressant agents, test of selectivity and sub-chronic studies.
    Psychopharmacology, 1984, Volume: 84, Issue:2

    Topics: Alanine; Animals; Antidepressive Agents; Avoidance Learning; Clomipramine; Fenclonine; Male; Mianserin; Rats; Rats, Inbred Strains; Serotonin Antagonists; Zimeldine

1984
Role of serotonin in memory: facilitation by alaproclate and zimeldine.
    Psychopharmacology, 1984, Volume: 84, Issue:4

    Topics: Alanine; Animals; Avoidance Learning; Cyproheptadine; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Male; Memory; Mice; Quipazine; Serotonin; Time Factors; Zimeldine

1984
Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants on beta-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortex.
    Journal of neural transmission, 1984, Volume: 59, Issue:1

    Topics: Alanine; Amines; Animals; Antidepressive Agents; Benzylamines; Binding Sites; Cerebral Cortex; Clenbuterol; Desipramine; Dihydroalprenolol; Male; Mianserin; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Spiperone; Zimeldine

1984
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
    Journal of neural transmission, 1980, Volume: 47, Issue:4

    Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; p-Chloroamphetamine; Pain; Pyridines; Rats; Serotonin; Zimeldine

1980