Page last updated: 2024-09-03

alanyl-alanyl-phenylalanine chloromethyl ketone and epoxomicin

alanyl-alanyl-phenylalanine chloromethyl ketone has been researched along with epoxomicin in 3 studies

Compound Research Comparison

Studies
(alanyl-alanyl-phenylalanine chloromethyl ketone)
Trials
(alanyl-alanyl-phenylalanine chloromethyl ketone)
Recent Studies (post-2010)
(alanyl-alanyl-phenylalanine chloromethyl ketone)
Studies
(epoxomicin)
Trials
(epoxomicin)
Recent Studies (post-2010) (epoxomicin)
17022510111

Protein Interaction Comparison

ProteinTaxonomyalanyl-alanyl-phenylalanine chloromethyl ketone (IC50)epoxomicin (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.98
Proteasome subunit beta type-1Homo sapiens (human)1.25
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.98
Proteasome subunit beta type-5Homo sapiens (human)0.0256
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.98
Proteasome subunit beta type-2Homo sapiens (human)0.57
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.98
GABA theta subunitRattus norvegicus (Norway rat)0.98
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.98

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bennink, JR; Chen, W; Crews, CM; Myung, J; Princiotta, MF; Schubert, U; Yewdell, JW1
de Castro, JA; Marcilla, M; Villasevil, EM1
Antón, LC; Del Val, M; Guil, S; López-Ferreras, L; Sánchez, C; Villasevil, EM1

Other Studies

3 other study(ies) available for alanyl-alanyl-phenylalanine chloromethyl ketone and epoxomicin

ArticleYear
Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-16, Volume: 98, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Aminopeptidases; Animals; Antigen Presentation; Antigens; Boronic Acids; Bortezomib; CD8-Positive T-Lymphocytes; Cell Survival; Cysteine Endopeptidases; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Resistance; Endopeptidases; Enzyme Activation; H-2 Antigens; Leupeptins; Lymphoma, T-Cell; Mice; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Peptide Fragments; Phenols; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrazines; Selection, Genetic; Serine Endopeptidases; Sulfones; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyramine; Ubiquitins

2001
Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules.
    European journal of immunology, 2008, Volume: 38, Issue:3

    Topics: Acids; Amino Acid Chloromethyl Ketones; Aminopeptidases; Antigen Presentation; Brefeldin A; Cell Line; Cell Line, Tumor; Coumarins; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Stability; Histocompatibility Antigens Class I; HLA-B27 Antigen; Humans; Hydrogen-Ion Concentration; Indoles; Lymphocytes; Oligopeptides; Proteasome Endopeptidase Complex; RNA Interference; RNA, Small Interfering; Serine Endopeptidases; Serine Proteinase Inhibitors

2008
Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of Tripeptidyl peptidase II.
    Biochimica et biophysica acta, 2010, Volume: 1803, Issue:9

    Topics: Amino Acid Chloromethyl Ketones; Aminopeptidases; Cell Line, Tumor; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; HeLa Cells; Humans; Oligopeptides; Polyubiquitin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Multimerization; Protein Processing, Post-Translational; Serine Endopeptidases; Ubiquitinated Proteins; Unfolded Protein Response

2010