alantrypinone and 1-(4-ethynylphenyl)-4-propyl-2-6-7-trioxabicyclo(2.2.2)octane

alantrypinone has been researched along with 1-(4-ethynylphenyl)-4-propyl-2-6-7-trioxabicyclo(2.2.2)octane* in 1 studies

Other Studies

1 other study(ies) available for alantrypinone and 1-(4-ethynylphenyl)-4-propyl-2-6-7-trioxabicyclo(2.2.2)octane

Article	Year
Receptor assay-guided isolation of anti-GABAergic insecticidal alkaloids from a fungal culture. Journal of agricultural and food chemistry, 2004, Jun-16, Volume: 52, Issue:12 The gamma-aminobutyric acid (GABA) receptor bears sites of action for insecticides. To discover GABA receptor-directed insecticides in natural products, fungal culture extracts were screened for their ability to inhibit specific binding of the radiolabeled noncompetitive antagonist [3H]1-(4-ethynylphenyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane to housefly head membranes. The screening efforts led to the isolation of two alkaloids from Aspergillus terreus: PF1198A (alantrypinone) and PF1198B (serantrypinone), which had IC50 values of 0.34 and 2.1 microM, respectively, in this assay. These compounds were ca. 47-61-fold selective for housefly vs rat GABA receptors. Both compounds showed insecticidal activity against Myzus persicae in the range of 100-500 ppm. Binding assay-guided screening should provide significant opportunities for the identification of novel and selective insecticides. Topics: Alkaloids; Animals; Aspergillus; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; GABA Antagonists; Houseflies; Indoles; Insecticides; Quinazolines; Rats; Receptors, GABA; Tritium	2004

Article

Year

Receptor assay-guided isolation of anti-GABAergic insecticidal alkaloids from a fungal culture.

Journal of agricultural and food chemistry, 2004, Jun-16, Volume: 52, Issue:12

The gamma-aminobutyric acid (GABA) receptor bears sites of action for insecticides. To discover GABA receptor-directed insecticides in natural products, fungal culture extracts were screened for their ability to inhibit specific binding of the radiolabeled noncompetitive antagonist [3H]1-(4-ethynylphenyl)-4-n-propyl-2,6,7-trioxabicyclo[2.2.2]octane to housefly head membranes. The screening efforts led to the isolation of two alkaloids from Aspergillus terreus: PF1198A (alantrypinone) and PF1198B (serantrypinone), which had IC50 values of 0.34 and 2.1 microM, respectively, in this assay. These compounds were ca. 47-61-fold selective for housefly vs rat GABA receptors. Both compounds showed insecticidal activity against Myzus persicae in the range of 100-500 ppm. Binding assay-guided screening should provide significant opportunities for the identification of novel and selective insecticides.

Topics: Alkaloids; Animals; Aspergillus; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; GABA Antagonists; Houseflies; Indoles; Insecticides; Quinazolines; Rats; Receptors, GABA; Tritium

2004