alanine has been researched along with thiazoles in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (22.45) | 18.7374 |
| 1990's | 8 (8.16) | 18.2507 |
| 2000's | 34 (34.69) | 29.6817 |
| 2010's | 22 (22.45) | 24.3611 |
| 2020's | 12 (12.24) | 2.80 |
| Authors | Studies |
|---|---|
| Bellion, E; Faust, JR; Kirkley, DH | 1 |
| Deutsch, HF; Fett, JW | 1 |
| Burton, K | 1 |
| Schaffer, MH; Stark, GR | 1 |
| Hammarström, S; Strominger, JL | 1 |
| Allen, NE; Hobbs, JN; Preston, DA; Turner, JR; Wu, CY | 1 |
| d'Ischia, M; Havens, M; Napolitano, A; Prota, G; Tramposch, K | 1 |
| Tschiersch, B | 1 |
| Ballesteros, AO; Fernandez, VM; Martin Del Rio, R; Tebar, AR | 1 |
| Soda, K | 1 |
| Komai, T; Shindo, H | 1 |
| Foote, LJ; Keenan, BS; Kredich, NM | 1 |
| Schlee, D | 1 |
| Ellis, S; Fairwell, T; Lovins, RE | 1 |
| McKean, DJ; Peters, EH; Smithies, O; Waldby, JI | 1 |
| Blumenthal, A; Ezekiel, DH | 1 |
| Nakamura, M; Nakata, T; Nose, Y | 1 |
| Feingold, DS; Vance, DE | 1 |
| Dénes, G; Patthy, L | 1 |
| Kuhlman, DP; Tieckelmann, H; Tomlinson, RV; Torrence, PF | 1 |
| Fairwell, T; Lovins, RE | 1 |
| Ebata, M; Miyazaki, K; Otsuka, H | 1 |
| Halpern, B; Westley, JW | 1 |
| Goodwin, TW; Howells, DJ; Johnson, DB | 1 |
| Duan, J; Fernandes, BH; Jaramillo, J; Jung, GL; Mathis, D; McLeod, AL | 1 |
| Antón, V; Asensi, M; García de la Asunción, J; Lloret, A; Pallardó, FV; Sastre, J; Viña, J | 1 |
| Chiarugi, A; Moroni, F; Rapizzi, E | 1 |
| Carpenedo, R; Cozzi, A; Moroni, F | 1 |
| Chiarugi, A; Moroni, F | 1 |
| Conway, KA; Harper, JD; Lansbury, PT | 1 |
| Carpenedo, R; Cozzi, A; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Ambler, J; Baettig, U; Brown, L; Brundish, D; Cockcroft, X; Dell, C; Furzer, A; Garman, S; Janus, D; Kane, PD; Mitchelson, A; Smith, G; Talbot, MD; Tweed, M; Walker, CV; Wills, N | 1 |
| Allen, M; Ambler, J; Butler, K; Cockcroft, X; Dunnet, K; Hayler, J; Kane, PD; LeGrand, D; Lugrin, F; Menear, K; Mitchelson, A; Price, R; Talbot, M; Tweed, M; Wills, N | 1 |
| Bhattacharya, S; Seshadri, TP; Singh, UP; Thomas, M | 1 |
| Egebjerg, J; Frydenvang, K; Jensen, HS; Johansen, TN; Krogsgaard-Larsen, P; Nielsen, B; Stensbøl, TB | 1 |
| Banan, A; Fitzpatrick, L; Keshavarzian, A; Zhang, Y | 1 |
| Arai-Otsuki, S; Fukami, T; Haga, Y; Hirose, M; Ihara, M; Ishihara, A; Iwaasa, H; Iwama, T; Kanatani, A; Kannoa, T; Keen, SL; Morishima, H; Sakuraba, A | 1 |
| Miller, DA; Walsh, CT | 1 |
| Golbik, R; Hübner, G; Jordan, F; Seliger, B; Spinka, M; Tittmann, K; Wang, J | 1 |
| McCarthy, K; Routh, R; Welbourne, T | 1 |
| Hutchinson, I; Jennings, SA; Stevens, MF; Vishnuvajjala, BR; Westwell, AD | 1 |
| Battarbee, H; Coates, G; McCarthy, K; Routh, R; Su, G; Welbourne, T | 1 |
| Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Regueiro-Ren, A; Ueda, Y | 1 |
| Blüher, M; Lübben, G; Paschke, R | 1 |
| Du, HN; Hu, HY; Hu, J; Li, HT; Luo, XY; Tang, L; Zhou, JW | 1 |
| Banerjee, J; Wedegaertner, PB | 1 |
| Cornejo, J; Cox, L; Fernandes, MC; Hermosín, MC; Zsolnay, A | 1 |
| Gipson, JD; Kim, YR; Mennen, SM; Miller, SJ | 1 |
| Sebti, SM; Wang, DA | 1 |
| Dang, Q; Erion, MD; Jiang, T; Kasibhatla, SR; Lipscomb, WN; Potter, SC; Reddy, KR; Reddy, MR; van Poelje, PD | 1 |
| Kim, HJ; Kim, J; Kim, KS; Kim, M; Kim, SH; Koh, SH; Lee, KW; Lee, YB; Lee, YJ | 1 |
| Keasling, JD; Muller, SJ; Wang, K | 1 |
| Egebjerg, J; Holm, MM; Kastrup, JS; Lunn, ML; Traynelis, SF | 1 |
| He, Y; Luo, Y; Tang, H; Zhou, H | 1 |
| Dartt, DA; Ríos, JD; Shatos, M; Tran, H; Urashima, H | 1 |
| Cornejo, J; Cox, L; Fernandes, MC; Hermosín, MC | 1 |
| Dikov, D; Otzen, DE; Pedersen, JS | 1 |
| Cheng, YQ; Shen, B; Tang, GL | 1 |
| Bertram, A; Maulucci, N; Mohd Nor, SM; New, OM; Pattenden, G | 1 |
| Farthing, AK; Liu, K; Meinke, PT; Shi, YJ; Xu, L | 1 |
| Gupta, R; Marek, P; Raleigh, DP | 1 |
| Ludwig, C; Mootz, HD; Schwarzer, D | 1 |
| Chung, RS; Howells, C; Karafin, A; Palumaa, P; Tõugu, V; West, AK; Zovo, K | 1 |
| Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M | 1 |
| Brodmann, T; Bülow, L; Carlomagno, T; Eggert, U; Frank, R; Girbig, AK; Kalesse, M; Malek, NP; Nickeleit, I; Rentsch, A; Sasse, F; Steinmetz, H | 1 |
| Nishi, T; Okuno, A; Shiiki, T; Takagi, T; Takahashi, M; Tamaki, K; Tanaka, J; Tsukada, T; Yoshida, T | 1 |
| Colombo, M; Mazzoleni, M; Saliu, F; Tremolada, P; Vighi, M | 1 |
| Lu, J; Xie, Z; Zhang, H; Zhang, WJ; Zhang, Y; Zhou, G | 1 |
| Cashion, DK; Dang, Q; DaRe, J; Erion, MD; Fan, Y; Gibson, T; Jacintho, JD; Jiang, T; Kasibhatla, SR; Lemus, R; Li, H; Li, W; Liu, Y; Potter, SC; Sun, Z; Taplin, F; Tian, F; van Poelje, PD | 1 |
| Ahemad, M; Khan, MS | 1 |
| Carrothers, TJ; Habtemariam, B; Kastrissios, H; Khariton, T; Kshirsagar, S; Mager, DE; Rohatagi, S; Walker, JR | 1 |
| Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J | 1 |
| Lepist, EI; Maclennan, K; Murray, B; Phan, TK; Ray, AS; Roy, A; Tong, L | 1 |
| Chang, AY; Wang, M | 1 |
| Aucoin, D; Hoos, MD; Kotarba, AE; Smith, SO; Van Nostrand, WE | 1 |
| Eguchi, F; Hamamoto, H; Hayashi, K; Matsugi, M; Miyazaki, A; Shioiri, T; Sugiyama, Y; Takahashi, H | 1 |
| Cho, CS; Kang, YM; Kim, JH; Kim, SK; Lee, DH; Lee, SK; Lee, ST; Lee, YC; Park, SH; Park, W; Park, YW; Rew, JS; Yoo, WH | 1 |
| Baeten, JM; Wyatt, C | 1 |
| Andrade-Villanueva, J; Callebaut, C; Cao, H; Cheng, AK; Crofoot, G; Custodio, JM; DeJesus, E; Fordyce, MW; Koenig, E; Martin, H; McCallister, S; Molina, JM; Oka, S; Plummer, A; Podzamczer, D; Post, F; Pozniak, A; Saag, M; Sax, PE; Thompson, M; Trottier, B; Wohl, D; Yin, MT; Zhong, L | 1 |
| Bottomley, SP; Ellisdon, AM; Hughes, VA; Lupton, CJ; Steer, DL; Wintrode, PL | 1 |
| Asano, A; Doi, M; Minoura, K; Yamada, T | 1 |
| Boys, SK; Carragher, NO; Hulme, AN; Johnston, HJ; Makda, A | 1 |
| Camargo, C; Giesler, LJ; Hunt, TE; Siegfried, BD | 1 |
| Kantminienė, K; Matulis, D; Mickevičius, V; Paketurytė, V; Vaškevičienė, I; Zubrienė, A | 1 |
| Basançelebi, O; Başlar, M; Cengiz, MF; Kılıçlı, M | 1 |
| Gong, W; Han, P; Hu, B; Jiang, M; Li, B; Liang, G; Zhang, T; Zhang, W | 1 |
| Barlow, A; Barlow, B; Claassen, CW; Heavner, JJ; Heavner, MS; Landolf, KM; Yeung, SYA | 1 |
| Şimşek Yavuz, S; Ünal, S | 1 |
| Anastasiou, IA; Eleftheriadou, I; Tentolouris, A; Tentolouris, N; Tsilingiris, D | 1 |
| Chen, W; McGee, R; Paulitz, T; Porter, L; Schroeder, K; Van Vleet, S; Vandemark, G; Wang, M | 1 |
| Nerli, E; Norden, C; Rocha-Martins, M | 1 |
| de Vries, RH; Kuipers, OP; Roelfes, G; Viel, JH | 1 |
| Kumar, D; Trivedi, N; Verma, A | 1 |
| Chen, H; Fan, Y; Mu, N; Ruan, Z; Wang, S; Wang, W; Zhu, K | 1 |
| Wen, S; Xu, X; Yadav, AK; Yu, L | 1 |
| Cicka, D; Sukhatme, VP | 1 |
| Assis, LC; da Cunha, EFF; de Almeida La Porta, F; de Castro Ramalho, T; de Castro, AA; de Jesus, JPA; Kuca, K; Nepovimova, E | 1 |
6 review(s) available for alanine and thiazoles
| Article | Year |
|---|---|
[Hydrocyanic acid and hydrocyanic acid glycoside. A review].
Topics: Alanine; Arthropods; Bacteria; Cyanides; Fungi; Glycosides; Hydrogen Cyanide; Lipotropic Agents; Plants; Thiazoles; Thiocyanates | 1967 |
[Thiamine: biosynthesis and its regulation].
Topics: Adenine Nucleotides; Alanine; Antimetabolites; Bacillus subtilis; Carboxy-Lyases; Coenzymes; Escherichia coli; Glyoxylates; Methionine; Mutation; Purines; Pyrimidines; Saccharomyces cerevisiae; Salmonella typhimurium; Thiamine; Thiamine Pyrophosphate; Thiazoles | 1972 |
Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Immunomodulation; Interferon-alpha; Lopinavir; Nelfinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; Purines; Pyrazoles; Ribavirin; Ritonavir; SARS-CoV-2; Sulfonamides; Thiazoles | 2020 |
Antiviral treatment of COVID-19
Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; Pyrazines; Ritonavir; SARS-CoV-2; Thiazoles | 2020 |
Possible treatment and strategies for COVID-19: review and assessment.
Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiparasitic Agents; Antiviral Agents; Cannabinoids; Chloroquine; Complement Inactivating Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 Vaccines; Dexamethasone; Drug Combinations; Enzyme Inhibitors; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Pyrazines; Ritonavir; SARS-CoV-2; Teicoplanin; Tetracyclines; Thiazoles | 2020 |
Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Topics: Adenosine Monophosphate; Alanine; Amides; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Chloroquine; COVID-19; COVID-19 Serotherapy; Drug Combinations; Humans; Hydroxychloroquine; Immunization, Passive; Indoles; Interferons; Ivermectin; Lopinavir; Nitro Compounds; Oseltamivir; Purines; Pyrazines; Pyrazoles; Ribavirin; Ritonavir; Sulfonamides; Thiazoles | 2021 |
3 trial(s) available for alanine and thiazoles
| Article | Year |
|---|---|
Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes.
Topics: Aged; Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genotype; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Proline; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Treatment Outcome | 2003 |
Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Butanones; Diclofenac; Double-Blind Method; Drug Administration Schedule; Gastric Mucosa; Humans; Meloxicam; Middle Aged; Misoprostol; Nabumetone; Quinolones; Stomach Ulcer; Thiazines; Thiazoles; Treatment Outcome | 2014 |
Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials.
Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Arthralgia; Bone Density; Carbamates; CD4 Lymphocyte Count; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; Headache; HIV Infections; Humans; Kidney; Male; Nausea; Organophosphonates; Quinolones; Respiration Disorders; Sleep Initiation and Maintenance Disorders; Tenofovir; Thiazoles; Treatment Outcome; Viral Load | 2015 |
89 other study(ies) available for alanine and thiazoles
| Article | Year |
|---|---|
The biosynthesis of the thiazole moiety of thiamine in Salmonella Typhimurium.
Topics: Alanine; Glycine; Methionine; Salmonella typhimurium; Thiamine; Thiazoles; Tyrosine | 1976 |
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine | 1976 |
Analysis of RNA turnover in bacteria using histidine as a radioactivity trap for (2-H)adenine nucleotides.
Topics: Adenine; Adenine Nucleotides; Alanine; Bacillus subtilis; Deoxyribonucleases; DNA Replication; Escherichia coli; Histidine; Kinetics; Mathematics; Protein Biosynthesis; RNA, Bacterial; Salmonella typhimurium; Species Specificity; Thiazoles | 1976 |
Ring cleavage of 2-iminothiazolidine-4-carboxylates by catalytic reduction. A potential method for unblocking peptides formed by specific chemical cleavage at half-cystine residues.
Topics: Alanine; Binding Sites; Carboxylic Acids; Carboxypeptidases; Cystine; Imines; Kinetics; Macromolecular Substances; Methods; Molecular Weight; Peptides; Protein Binding; Temperature; Thiazoles | 1976 |
Formation of 5,5-dimethyl-delta2-thiazoline-4-carboxylic acid during cleavage of penicillin G by D-alanine carboxypeptidase from Bacillus stearothermophilus.
Topics: Alanine; Carboxypeptidases; Electrophoresis, Paper; Geobacillus stearothermophilus; Penicillin G; Thiazoles | 1976 |
Antibacterial properties of the bicyclic pyrazolidinones.
Topics: Alanine; Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carrier Proteins; Cell Wall; DNA, Bacterial; Enterobacter; Hexosyltransferases; Molecular Structure; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; Providencia; Pyrazoles; RNA, Bacterial; Thiazoles | 1990 |
2-Aryl-1,3-thiazolidines as masked sulfhydryl agents for inhibition of melanogenesis.
Topics: Alanine; Carboxylic Acids; Chromatography, Gel; Dihydroxyphenylalanine; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Melanins; Molecular Structure; Monophenol Monooxygenase; Spectrophotometry; Thiazines; Thiazoles; Tyrosine | 1991 |
Studies on the quaternary structure of the first enzyme for histidine biosynthesis.
Topics: Adenosine Triphosphate; Alanine; Allosteric Regulation; Chromatography, Gel; Escherichia coli; Feedback; Histidine; Molecular Weight; Organophosphorus Compounds; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Structure-Activity Relationship; Thiazoles | 1973 |
Microdetermination of D-amino acids and D-amino acid oxidase activity with 3,methyl-2-benzothiazolone hydrazone hydrochloride.
Topics: Alanine; Amino Acids; Catalase; D-Amino-Acid Oxidase; Hydrazines; Keto Acids; Methionine; Methods; Microchemistry; Perchlorates; Spectrophotometry; Spectrum Analysis; Stereoisomerism; Thiazoles; Trichloroacetic Acid | 1968 |
Structural specificities for the active transport system of thiamine in rat small intestine.
Topics: Alanine; Animals; Binding Sites; Biological Transport, Active; Electrophoresis, Paper; Fructose; Galactose; Glucose; Hydrogen-Ion Concentration; Intestine, Small; Leucine; Male; Models, Chemical; Pyrimidines; Rats; Structure-Activity Relationship; Sulfur; Sulfur Radioisotopes; Thiamine; Thiamine Pyrophosphate; Thiazoles | 1974 |
The stoichiometry and kinetics of the inducible cysteine desulfhydrase from Salmonella typhimurium.
Topics: Acrylates; Alanine; Amino Acids; Ammonium Sulfate; Bacterial Proteins; Binding, Competitive; Borohydrides; Carboxylic Acids; Cysteine; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Lyases; Mathematics; Models, Chemical; Optical Rotatory Dispersion; Pyruvates; Salmonella typhimurium; Streptomycin; Sulfides; Thiazoles | 1973 |
Quantitative protein sequencing using mass spectrometry: N-terminal sequence analysis of small quantities of peptides from the mass spectral analysis of the N-methylthiourea derivatives.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chemical Phenomena; Chemistry; Cyclization; Evaluation Studies as Topic; Fluoroacetates; Glutamates; Glycine; Hot Temperature; Hydantoins; Mass Spectrometry; Methods; Methylamines; Oligopeptides; Peptides; Phenylalanine; Proteins; Thiazoles; Thiocyanates; Thiourea; Volatilization | 1972 |
Amino acid sequence determination with radioactive proteins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Bence Jones Protein; Carbon Dioxide; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Colorimetry; Evaluation Studies as Topic; Humans; Indicators and Reagents; Isotope Labeling; Methods; Plant Viruses; Ribonucleases; Thiazoles; Tritium; Viral Proteins | 1974 |
A comparison of the rates of RNA and protein synthesis in Escherichia coli cells partially starved for different amino acids.
Topics: Alanine; Amino Acids; Bacterial Proteins; Butyrates; Depression, Chemical; Escherichia coli; Feedback; Histidine; Keto Acids; Ribosomes; RNA, Bacterial; Thiazoles; Time Factors; Tryptophan | 1968 |
Effect of aliphatic amino acids and citric acid cycle compounds on early thiamine production by thiazoleless mutant of Escherichia coli.
Topics: Alanine; Amino Acids; Ammonium Chloride; Aspartic Acid; Carbon Isotopes; Culture Media; Dicarboxylic Acids; Escherichia coli; Formates; Fumarates; Glucose; Glutamates; Lysine; Malates; Mutation; Pyruvates; Serine; Succinates; Thiamine; Thiazoles; Valine | 1968 |
Additive Edman degradation to sequence small peptides.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Chromatography, Gas; Hydantoins; Methods; Peptides; Phenylalanine; Serine; Silicones; Thiazoles; Valine | 1971 |
Altered repression behaviour in a feedback insensitive mutant of Escherichia coli K12.
Topics: Alanine; Alcohol Oxidoreductases; Amino Alcohols; Cold Temperature; Drug Resistance, Microbial; Enzyme Repression; Escherichia coli; Feedback; Histidine; Imidazoles; Mutation; Operon; Thiazoles | 1970 |
Precursors of the pyrimidine and thiazole rings of thiamine.
Topics: Acetates; Alanine; Aspartic Acid; Bacillus subtilis; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Formates; Methionine; Models, Biological; Pyrimidines; Spectrophotometry; Thiamine; Thiazoles; Tritium | 1967 |
Quantitative protein sequencing using mass spectrometry: mass spectral analysis of 2-anilino-5-thiazolinone derivatives of amino acids without prior conversion to the phenyl thiohydantoins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aniline Compounds; Animals; Arginine; Autoanalysis; Cattle; Chemical Phenomena; Chemistry; Drug Stability; Glutamates; Hydantoins; Lysine; Mass Spectrometry; Methods; Phenylalanine; Ribonucleases; Serine; Sulfides; Thiazoles; Thiocyanates; Threonine; Tyrosine | 1971 |
Studi on siomycin. II. The composition and degradation products of siomycin A.
Topics: Acetaldehyde; Alanine; Amino Acids; Anti-Bacterial Agents; Butyrates; Carbon; Chemical Phenomena; Chemistry; Cysteine; Optical Rotatory Dispersion; Oxidation-Reduction; Propionates; Pyruvates; Quinazolines; Thiazoles; Threonine; Valine | 1969 |
Optical resolution of D,L amino acids by gas chromatography and mass spectrometry.
Topics: Alanine; Amino Acids; Aminobutyrates; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Glycine; Leucine; Proline; Spectrum Analysis; Thiazoles | 1965 |
Observations on the biosynthesis of thiamine in yeast.
Topics: Acetates; Alanine; Chromatography, Gas; Formates; In Vitro Techniques; Methionine; Orotic Acid; Pyrimidines; Saccharomyces; Thiamine; Thiazoles | 1966 |
Comparative studies on differential inhibition of the renin - angiotensin system in the anesthetized guinea pig.
Topics: Alanine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Captopril; Guinea Pigs; Imidazoles; Losartan; Male; Nephrectomy; Pyridines; Renin; Renin-Angiotensin System; Tetrazoles; Thiazoles | 1995 |
Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Aging; Alanine; Animals; Antioxidants; Brain; Deoxyguanosine; DNA Damage; DNA, Mitochondrial; Drug Administration Schedule; Glutathione; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxidation-Reduction; Postural Balance; Sulfur; Thiazoles | 1998 |
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound.
Topics: Alanine; Animals; Cataract; Ciliary Body; Eye; Hydrolases; Iris; Kynurenine; Kynurenine 3-Monooxygenase; Lens, Crystalline; Lyases; Male; Mixed Function Oxygenases; Rabbits; Sulfonamides; Thiazoles; Tissue Distribution; Transaminases; Tryptophan Oxygenase | 1999 |
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Enzyme Inhibitors; Gerbillinae; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 1999 |
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.
Topics: Alanine; Animals; Brain; Enzyme Inhibitors; Hydroxylation; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Mixed Function Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Spleen; Sulfonamides; Thiazoles | 1999 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Sulfonamides; Thiazoles | 1999 |
The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position.
Topics: Alanine; Antithrombins; Arginine; Chymotrypsin; Drug Design; Factor Xa Inhibitors; Fibrinolysin; Kallikreins; Models, Molecular; Molecular Structure; Pipecolic Acids; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Thiazoles; Thrombin; Trypsin | 2000 |
The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors.
Topics: Administration, Oral; Alanine; Animals; Antithrombins; Biological Availability; Chymotrypsin; Drug Design; Fibrinolysin; Kinetics; Molecular Conformation; Molecular Structure; Partial Thromboplastin Time; Structure-Activity Relationship; Sulfonamides; Thiazoles; Thrombosis; Trypsin | 2000 |
Ethyl 2-[N-(tert-butyloxycarbonyl)-L-alanylamino]-4-methyl-1, 3-thiazole-5-carboxylate reveals a trans orientation of the preceding amide N--H with respect to the thiazole-ring sulfur.
Topics: Alanine; Crystallography, X-Ray; DNA; Hydrogen Bonding; Molecular Structure; Thiazoles | 2000 |
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.
Topics: Alanine; Animals; Chromatography, High Pressure Liquid; Cloning, Molecular; Excitatory Amino Acid Agonists; In Vitro Techniques; Kinetics; Membrane Potentials; Molecular Conformation; Oocytes; Patch-Clamp Techniques; Rats; Receptors, AMPA; Stereoisomerism; Thiazoles; Transcription, Genetic; Xenopus laevis | 2001 |
OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability.
Topics: Actins; Alanine; Antioxidants; Blotting, Western; Caco-2 Cells; Cytoskeleton; Fluorescent Dyes; Humans; Immunoblotting; Intestinal Mucosa; Microscopy, Fluorescence; Oxidants; Oxidation-Reduction; Permeability; Quinolones; Reactive Oxygen Species; Thiazoles | 2001 |
Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors.
Topics: Alanine; Amino Acid Sequence; Animals; Appetite Depressants; Binding Sites; Binding, Competitive; Carbamates; Humans; Ligands; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides, Cyclic; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Neuropeptide Y; Sequence Homology, Amino Acid; Thiazoles | 2001 |
Yersiniabactin synthetase: probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit.
Topics: Acyl Carrier Protein; Alanine; Amino Acid Isomerases; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Bacterial Proteins; Catalytic Domain; Coenzyme A Ligases; Enzyme Activation; Iron-Binding Proteins; Molecular Weight; Peptide Chain Initiation, Translational; Peptide Synthases; Periplasmic Binding Proteins; Phenols; Protein Structure, Tertiary; Serine; Siderophores; Substrate Specificity; Thiazoles; Yersinia pestis | 2001 |
Consequences of a modified putative substrate-activation site on catalysis by yeast pyruvate decarboxylase.
Topics: Alanine; Catalysis; Cysteine; Deuterium Oxide; Enzyme Activation; Hydrogen; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Solvents; Substrate Specificity; Thiamine Pyrophosphate; Thiazoles | 2001 |
Troglitazone inhibits glutamine metabolism in rat mesangial cells.
Topics: Alanine; Alanine Transaminase; Animals; Cells, Cultured; Chromans; Collagen; Deamination; Dose-Response Relationship, Drug; Glomerular Mesangium; Glutamic Acid; Glutamine; Glycosaminoglycans; Male; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs.
Topics: Alanine; Antineoplastic Agents; Drug Stability; Hydrogen-Ion Concentration; Lysine; Prodrugs; Solubility; Structure-Activity Relationship; Thiazoles | 2002 |
Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells.
Topics: Acid-Base Equilibrium; Acids; Alanine; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Glomerular Mesangium; Hydrogen-Ion Concentration; Hypoglycemic Agents; Intracellular Fluid; Lactic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2002 |
Mild method for cleavage of dehydroalanine units: highly efficient conversion of nocathiacin I to nocathiacin IV.
Topics: Alanine; Anti-Bacterial Agents; Combinatorial Chemistry Techniques; Intercellular Signaling Peptides and Proteins; Molecular Structure; Peptides; Peptides, Cyclic; Thiazoles | 2002 |
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amino Acid Motifs; Benzothiazoles; Circular Dichroism; Escherichia coli; Glycine; Humans; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Synucleins; Thiazoles; Time Factors; Valine | 2003 |
Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.
Topics: Actins; Alanine; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; COS Cells; Cytoskeleton; Dose-Response Relationship, Drug; Gene Deletion; Guanine Nucleotide Exchange Factors; Humans; Immunoblotting; Luciferases; Models, Genetic; Molecular Sequence Data; Mutation; Neurons; Precipitin Tests; Protein Structure, Tertiary; Receptors, Glutamate; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Thiazoles; Thiazolidines; Transfection | 2004 |
Changes in dissolved organic carbon of soil amendments with aging: effect on pesticide adsorption behavior.
Topics: Adsorption; Alanine; Carbon; Environmental Pollution; Fungicides, Industrial; Pesticides; Soil; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
Thiazolylalanine-derived catalysts for enantioselective intermolecular aldehyde-imine cross-couplings.
Topics: Alanine; Aldehydes; Catalysis; Imines; Ketones; Stereoisomerism; Thiazoles | 2005 |
Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cysteine; DNA Primers; Genes, Tumor Suppressor; Glycine; Humans; In Situ Nick-End Labeling; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Promoter Regions, Genetic; Protein Biosynthesis; Protein Prenylation; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Sequence Homology, Amino Acid; Serine; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2005 |
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Topics: Adenosine Monophosphate; Alanine; Analysis of Variance; Animals; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Fructose-Bisphosphatase; Gluconeogenesis; Humans; Liver; Male; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Rats, Zucker; Spectrophotometry; Thiazoles | 2005 |
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; Collagen Type XI; Cytochromes c; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; Humans; Hybrid Cells; Indoles; Motor Neurons; Mutagenesis; Neuroblastoma; Phosphatidylinositol 3-Kinases; Point Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Trypan Blue; Valine | 2005 |
Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.
Topics: Alanine; Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Gene Library; Glycine; Hydrogel, Polyethylene Glycol Dimethacrylate; Isoleucine; Leucine; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles; Ultraviolet Rays; Valine; X-Ray Diffraction | 2005 |
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.
Topics: Alanine; Alternative Splicing; Animals; Brain; Crystallization; Dose-Response Relationship, Drug; Ibotenic Acid; Kinetics; Models, Molecular; Mutagenesis; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Structure, Tertiary; Receptors, AMPA; Synaptic Transmission; Thiazoles; Xenopus laevis | 2005 |
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.
Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; Endostatins; Escherichia coli; Fibril-Associated Collagens; Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Neovascularization, Pathologic; PC12 Cells; Protein Conformation; Protein Structure, Tertiary; Rats; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
OPC-12759 increases proliferation of cultured rat conjunctival goblet cells.
Topics: Alanine; Animals; Anti-Ulcer Agents; Antioxidants; Cell Proliferation; Cells, Cultured; Coloring Agents; Conjunctiva; Goblet Cells; Histocytochemistry; Keratin-7; Keratins; Ki-67 Antigen; Male; Mucin 5AC; Mucins; Quinolones; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 2006 |
Organic amendments affecting sorption, leaching and dissipation of fungicides in soils.
Topics: Adsorption; Alanine; Fungicides, Industrial; Porosity; Soil; Thiazoles | 2006 |
N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.
Topics: Acids; Alanine; Alkalies; Benzothiazoles; Glucagon; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutation; Spectrometry, Fluorescence; Thiazoles | 2006 |
Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
Topics: Alanine; Bacterial Proteins; Carrier Proteins; Genes, Bacterial; Lactams; Macrolides; Multigene Family; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases; Polyketide Synthases; Protein Structure, Tertiary; Streptomyces; Thiazoles; Thiones | 2007 |
Synthesis of libraries of thiazole, oxazole and imidazole-based cyclic peptides from azole-based amino acids. A new synthetic approach to bistratamides and didmolamides.
Topics: Alanine; Amino Acids; Animals; Chemistry, Organic; Chemistry, Pharmaceutical; Imidazoles; Models, Chemical; Oxazoles; Peptides, Cyclic; Thiazoles; Urochordata; Valine | 2007 |
Conversion of nocathiacin I to nocathiacin acid by a mild and selective cleavage of dehydroalanine.
Topics: Alanine; Carboxylic Acids; Intercellular Signaling Peptides and Proteins; Peptides; Peptides, Cyclic; Thiazoles | 2007 |
The fluorescent amino acid p-cyanophenylalanine provides an intrinsic probe of amyloid formation.
Topics: Alanine; Amino Acid Sequence; Amyloid; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescence; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Kinetics; Molecular Sequence Data; Nitriles; Phenylalanine; Point Mutation; Protein Binding; Thiazoles; Time Factors | 2008 |
Interaction studies and alanine scanning analysis of a semi-synthetic split intein reveal thiazoline ring formation from an intermediate of the protein splicing reaction.
Topics: Alanine; Alternative Splicing; Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Inteins; Kinetics; Molecular Sequence Data; Peptides; Plasmids; Protein Structure, Tertiary; Proteins; Spectrometry, Fluorescence; Thiazoles; Thiazolidines | 2008 |
Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.
Topics: Alanine; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cerebral Cortex; Chelating Agents; Copper; Dose-Response Relationship, Drug; Histidine; Metallothionein 3; Microscopy, Electron, Transmission; Mutation; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Thiazoles; Time Factors; Zinc | 2009 |
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2010 |
Synthesis and biological characterization of argyrin F.
Topics: Alanine; Antineoplastic Agents; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Humans; Kinetics; Peptide Hydrolases; Peptides, Cyclic; Protease Inhibitors; Proteasome Inhibitors; RNA Interference; RNA, Small Interfering; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Tryptophan | 2010 |
A prodrug approach towards the development of tricyclic-based FBPase inhibitors.
Topics: Alanine; Animals; Cells, Cultured; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Design; Enzyme Inhibitors; Haplorhini; Molecular Conformation; Organophosphonates; Prodrugs; Pyridines; Structure-Activity Relationship; Thiazoles | 2010 |
Field trial for evaluating the effects on honeybees of corn sown using Cruiser and Celest xl treated seeds.
Topics: Agriculture; Alanine; Animals; Bees; Dioxoles; Environmental Exposure; Insecticides; Lethal Dose 50; Neonicotinoids; Nitro Compounds; Oxazines; Pyrroles; Seeds; Thiamethoxam; Thiazoles; Zea mays | 2010 |
Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.
Topics: Alanine; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Gene Knockdown Techniques; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; RNA, Small Interfering; Thiazoles; Transfection; Up-Regulation | 2010 |
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Topics: Administration, Oral; Alanine; Amides; Animals; Biological Availability; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Male; Mice; Organophosphonates; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 2011 |
Effect of pesticides on plant growth promoting traits of greengram-symbiont, Bradyrhizobium sp. strain MRM6.
Topics: Alanine; Bradyrhizobium; Dose-Response Relationship, Drug; Fabaceae; Fungicides, Industrial; Glycine; Glyphosate; Herbicides; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Organothiophosphorus Compounds; Oxazines; Symbiosis; Thiamethoxam; Thiazoles; Triazines; Triazoles | 2011 |
Population pharmacokinetic model for a novel oral hypoglycemic formed in vivo: comparing the use of active metabolite data alone versus using data of upstream and downstream metabolites.
Topics: Aged; Alanine; Computer Simulation; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Models, Biological; Molecular Structure; Organophosphonates; Prodrugs; Thiazoles | 2012 |
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation | 2012 |
Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.
Topics: Adenine; Alanine; Caco-2 Cells; Carbamates; Cobicistat; HIV Protease Inhibitors; Humans; Intestinal Absorption; Tenofovir; Thiazoles | 2012 |
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma.
Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines | 2013 |
Fine mapping of the amyloid β-protein binding site on myelin basic protein.
Topics: Alanine; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Mutagenesis, Site-Directed; Myelin Basic Protein; Peptide Fragments; Thiazoles | 2013 |
A synthesis of all stereoisomers of tenuecyclamide A employing a fluorous-Fmoc strategy.
Topics: Alanine; Peptides; Peptides, Cyclic; Stereoisomerism; Thiazoles | 2013 |
Tenofovir alafenamide for HIV infection: is less more?
Topics: Adenine; Alanine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Quinolones; Tenofovir; Thiazoles | 2015 |
Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.
Topics: Alanine; Allosteric Site; Amyloidogenic Proteins; Ataxin-3; Benzothiazoles; Catalytic Domain; Chromatography, High Pressure Liquid; Disease Progression; Escherichia coli; Genetic Variation; Humans; Machado-Joseph Disease; Microscopy, Electron, Transmission; Mutagenesis; Peptide Mapping; Peptides; Protein Binding; Protein Folding; Protein Structure, Secondary; Tandem Mass Spectrometry; Thiazoles | 2015 |
Conformational transformation of ascidiacyclamide analogues induced by incorporating enantiomers of phenylalanine, 1-naphthylalanine or 2-naphthylalanine.
Topics: Alanine; Cell Survival; Crystallography, X-Ray; Cytotoxins; HL-60 Cells; Humans; Models, Molecular; Naphthalenes; Oxazoles; Peptides, Cyclic; Phenylalanine; Protein Conformation; Protein Folding; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2016 |
Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide.
Topics: Actins; Alanine; Cell Survival; Cyanobacteria; Cytoskeleton; Dose-Response Relationship, Drug; HCT116 Cells; Humans; Molecular Structure; Oligopeptides; Peptides; Structure-Activity Relationship; Thiazoles | 2016 |
Thiamethoxam Toxicity and Effects on Consumption Behavior in Orius insidiosus (Hemiptera: Anthocoridae) on Soybean.
Topics: Alanine; Anilides; Animals; Aphids; Dioxoles; Fungicides, Industrial; Glycine max; Heteroptera; Insecticides; Neonicotinoids; Nitro Compounds; Oxazines; Predatory Behavior; Pyrazoles; Pyrroles; Thiamethoxam; Thiazoles | 2017 |
N-Sulfamoylphenyl- and N-sulfamoylphenyl-N-thiazolyl-β-alanines and their derivatives as inhibitors of human carbonic anhydrases.
Topics: Alanine; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Hydrazones; Isoenzymes; Kinetics; Mitochondria; Protein Binding; Recombinant Proteins; Thiazoles | 2017 |
Reduction of pesticide residues from tomatoes by low intensity electrical current and ultrasound applications.
Topics: Alanine; Captan; Chromatography, Gas; Electricity; Food Contamination; Fruit; Limit of Detection; Neonicotinoids; Nitro Compounds; Oxazines; Pesticide Residues; Solanum lycopersicum; Sonication; Thiamethoxam; Thiazoles | 2018 |
Uptake and dissipation of metalaxyl-M, fludioxonil, cyantraniliprole and thiamethoxam in greenhouse chrysanthemum.
Topics: Alanine; Chrysanthemum; Dioxoles; Fungicides, Industrial; Guanidines; Humans; Insecticides; Neonicotinoids; ortho-Aminobenzoates; Pesticide Residues; Pesticides; Pyrazoles; Pyrroles; Soil; Soil Pollutants; Thiamethoxam; Thiazoles | 2020 |
In Vitro Data of Current Therapies for SARS-CoV-2.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; China; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Emetine; Homoharringtonine; Humans; Hydroxychloroquine; Ivermectin; Lopinavir; Nitro Compounds; Pandemics; Pneumonia, Viral; SARS-CoV-2; Teicoplanin; Thiazoles | 2020 |
Chickpea Seed Rot and Damping-Off Caused by Metalaxyl-Resistant
Topics: Alanine; Cicer; Plant Diseases; Pythium; Seeds; Thiazoles; Thiophenes | 2021 |
Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway.
Topics: Alanine; Animals; Animals, Genetically Modified; Azepines; Cell Proliferation; Diamines; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Microscopy, Confocal; Neural Stem Cells; Neurogenesis; Receptors, Notch; Retinal Neurons; Thiazoles; Zebrafish; Zebrafish Proteins | 2020 |
Rapid and Selective Chemical Editing of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) via Cu
Topics: Alanine; Anti-Bacterial Agents; Boronic Acids; Catalysis; Copper; Enterococcus faecalis; Microbial Sensitivity Tests; Nisin; Protein Processing, Post-Translational; Ribosomes; Solubility; Staphylococcus aureus; Thiazoles; Thiostrepton | 2021 |
Nosiheptide analogues as potential antibacterial agents via dehydroalanine region modifications: Semi-synthesis, antimicrobial activity and molecular docking study.
Topics: Alanine; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2021 |
Available drugs and supplements for rapid deployment for treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Repositioning; Flavonoids; Humans; Mice; Nitro Compounds; Pharmaceutical Preparations; SARS-CoV-2; Small Molecule Libraries; Teicoplanin; Thiazoles | 2021 |
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles | 2021 |