alanine and tenofovir diphosphate

alanine has been researched along with tenofovir diphosphate in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (64.29)24.3611
2020's5 (35.71)2.80

Authors

AuthorsStudies
Berger, D; Bredeek, UF; Callebaut, C; DeJesus, E; Fordyce, MW; Markowitz, M; Ramanathan, S; Rhee, MS; Ruane, PJ; Yale, K; Zhong, L1
Babusis, D; Hao, J; Lepist, EI; Murakami, E; Park, Y; Ray, AS; Wang, T1
Cottrell, ML; Emerson, CW; Garrett, KL; Gay, C; Kashuba, ADM; McCallister, S; Peery, A; Prince, HMA; Rooney, JF; Schauer, A; Sykes, C1
Chen, Q; Jin, X; Ouyang, B; Peng, Y; Sun, J; Wang, G; Zhang, J; Zhen, L; Zhou, F1
Bodwell, J; Kashuba, ADM; Patel, MV; Rodriguez-Garcia, M; Shen, Z; Wira, CR1
Barth, A; Lai, MT; Ma, B; McHale, CM1
Bensouda, S; Cone, RA; Date, AA; Ensign, LM; Fuchs, EJ; Gumber, S; Hanes, J; Hendrix, C; Hoang, T; Marzinke, M; Ortiz, JO; Rohan, L; Villinger, F; Xiao, P; Young, TW1
Bodwell, J; Patel, MV; Rodriguez-Garcia, M; Shen, Z; Wira, CR1
Kearney, B; Kolaris, C; Ling, KHJ; Majeed, SR; Tarnowski, T; Xiao, D; Zondlo, S1
Anderson, PL; Brooks, KM; Bushman, LR; Castillo-Mancilla, J; Ibrahim, ME; Kiser, JJ; MaWhinney, S; McCallister, S; McHugh, C; Morrow, M; Yager, J1
Alessi, T; Feldman, PL; Felx, M; Jain, R; Roller, S; Shelton, J; Singh, R; Wang, Y; Yang, B; Zane, D1
Alnouti, Y; Bade, AN; Cobb, DA; Cohen, SM; Deodhar, S; Edagwa, B; Gautam, N; Gendelman, HE; McMillan, J; Shetty, BLD; Smith, N1
Dobard, C; García-Lerma, JG; Gary, J; Gatto, G; Heneine, W; Holder, A; Johnson, L; Khalil, G; Krovi, A; Li, L; Luecke, E; Massud, I; Mills, P; Mitchell, J; Nishiura, K; Pan, Y; Ruone, S; van der Straten, A1
Liu, W; Yan, B; Yu, S1

Trials

3 trial(s) available for alanine and tenofovir diphosphate

ArticleYear
Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4

    Topics: Adenine; Adult; Alanine; Anti-Retroviral Agents; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nausea; Organophosphates; Organophosphonates; RNA, Viral; Single-Blind Method; Statistics, Nonparametric; Tenofovir; Viral Load; Young Adult

2013
Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues.
    The Journal of antimicrobial chemotherapy, 2017, 06-01, Volume: 72, Issue:6

    Topics: Adenine; Adult; Alanine; Cervix Uteri; Drug Administration Schedule; Epithelial Cells; Female; Gastrointestinal Tract; Humans; Intestinal Mucosa; Leukocytes, Mononuclear; Middle Aged; Mucous Membrane; Organophosphates; Pre-Exposure Prophylaxis; Rectum; Tenofovir; Tissue Distribution; Vagina; Young Adult

2017
Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study.
    Journal of acquired immune deficiency syndromes (1999), 2020, 07-01, Volume: 84, Issue:3

    Topics: Adenine; Adolescent; Adult; Alanine; Anti-HIV Agents; Cross-Over Studies; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Male; Medication Adherence; Middle Aged; Organophosphates; Polyphosphates; Pre-Exposure Prophylaxis; Prospective Studies; Tenofovir; Young Adult

2020

Other Studies

11 other study(ies) available for alanine and tenofovir diphosphate

ArticleYear
Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:6

    Topics: Adenine; Alanine; Animals; Cells, Cultured; Dogs; Hepatitis B virus; Hepatocytes; Humans; Liver; Male; Organophosphates; Tenofovir

2015
Simultaneous determination of tenofovir alafenamide and its active metabolites tenofovir and tenofovir diphosphate in HBV-infected hepatocyte with a sensitive LC-MS/MS method.
    Journal of pharmaceutical and biomedical analysis, 2017, Nov-30, Volume: 146

    Topics: Adenine; Alanine; Anti-HIV Agents; Cell Line, Tumor; Chromatography, Liquid; DNA Replication; Half-Life; Hep G2 Cells; Hepatocytes; HIV Infections; HIV-1; Humans; Organophosphates; Prodrugs; Tandem Mass Spectrometry; Tenofovir; Virus Replication

2017
Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells.
    Scientific reports, 2017, 12-18, Volume: 7, Issue:1

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Contraceptive Agents; Contraceptives, Oral, Hormonal; Female; Genitalia, Female; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphates; Progestins; Tenofovir

2017
Establishment of intracellular tenofovir-diphosphate as the key determinant for in vitro-in vivo translation of antiviral efficacy.
    Antiviral research, 2018, Volume: 151

    Topics: Adenine; Alanine; Anti-HIV Agents; Cytoplasm; Databases, Factual; Dose-Response Relationship, Drug; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Meta-Analysis as Topic; Organophosphates; Prodrugs; Tenofovir; Viral Load; Virus Replication

2018
Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2019, Volume: 138

    Topics: Adenine; Administration, Rectal; Alanine; Animals; Anti-HIV Agents; Anti-Infective Agents; Enema; HIV Infections; HIV-1; Homosexuality, Male; Male; Mice; Organophosphates; Organophosphonates; Pre-Exposure Prophylaxis; Prodrugs; Rectum; Sexual and Gender Minorities; Tenofovir

2019
Epithelial Cells and Fibroblasts from the Human Female Reproductive Tract Accumulate and Release TFV and TAF to Sustain Inhibition of HIV Infection of CD4+ T cells.
    Scientific reports, 2019, 02-12, Volume: 9, Issue:1

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cervix Uteri; Drug Resistance, Multiple; Endometrium; Epithelial Cells; Female; Fibroblasts; Genitalia, Female; HIV Infections; Humans; Middle Aged; Organophosphates; Tenofovir; Vagina

2019
The determination of human peripheral blood mononuclear cell counts using a genomic DNA standard and application in tenofovir diphosphate quantitation.
    Analytical biochemistry, 2019, 11-15, Volume: 585

    Topics: Adenine; Alanine; Cell Count; Chromatography, High Pressure Liquid; DNA; Fluorescent Dyes; Genomics; Humans; Image Cytometry; Intercalating Agents; Leukocytes, Mononuclear; Organophosphates; Prodrugs; Tandem Mass Spectrometry; Tenofovir

2019
A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs.
    Microbiology spectrum, 2021, 09-03, Volume: 9, Issue:1

    Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Dogs; Edema; HIV Infections; HIV-1; Infusions, Subcutaneous; Male; Organophosphates; Pre-Exposure Prophylaxis; Rats; Tenofovir

2021
Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles.
    Nature communications, 2021, 09-16, Volume: 12, Issue:1

    Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Drug Stability; Female; HIV Infections; HIV-1; Humans; Male; Nanoparticles; Organophosphates; Prodrugs; Rats, Sprague-Dawley; Tenofovir; Therapeutic Equivalency

2021
Safety and efficacy of a biodegradable implant releasing tenofovir alafenamide for vaginal protection in a macaque model.
    The Journal of antimicrobial chemotherapy, 2022, 10-28, Volume: 77, Issue:11

    Topics: Absorbable Implants; Alanine; Animals; Anti-HIV Agents; Emtricitabine; Female; HIV; HIV Infections; Macaca; Necrosis; Simian Immunodeficiency Virus; Tenofovir

2022
Effect of alcohol exposure on the efficacy and safety of tenofovir alafenamide fumarate, a major medicine against human immunodeficiency virus.
    Biochemical pharmacology, 2022, Volume: 204

    Topics: Adenine; Alanine; Alcohol Drinking; Anti-HIV Agents; Carboxylic Ester Hydrolases; Chromatography, Liquid; Ethanol; Fumarates; HIV; HIV Infections; Humans; Lipids; Organophosphates; Tandem Mass Spectrometry; Tenofovir

2022