alanine and pyrroles

alanine has been researched along with pyrroles in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (18.31)	18.7374
1990's	3 (4.23)	18.2507
2000's	14 (19.72)	29.6817
2010's	24 (33.80)	24.3611
2020's	17 (23.94)	2.80

Authors

Authors	Studies
Kurelec, B	1
Barton, RL; Fix, DV; Gutowski, MC; Johnson, DA; Scott, WL	1
Bocker, H; Haupt, I	1
Hamuro, Y; Nishikawa, K; Suzuoki, Z; Watari, W	1
Chandra, P; Hausmann, S; Metz, A	1
Lundgren, D; Ogur, M	1
Shemin, D	1
Gott, CL; Qadri, SM; Williams, RP	1
Glöde, J; Gross, H; Lisý, V; Podŭska, K; Rudinger, J; Skoda, J	1
Hanck, A; Schreiner, A	1
Bocchi, V; Gardini, GP; Pinza, M	1
Chambers, P; Hill, DL	1
Brown, AD; Jackson, DS; Powers, JC; Schaeper, RJ	1
Alaiz, M; Hidalgo, FJ; Zamora, R	1
Bair, KW; Boger, DL; Ishii, T; Woods, CR; Wu, B	1
Deore, BA; Kishimoto, M; Kitano, T; Nagaoka, T; Okuno, H; Siigi, H; Yakabe, H	1
Adachi-Akahane, S; Ichijo, H; Nagao, T; Yamaguchi, S; Yoshioka, K; Zhorov, BS	1
ARIMURA, GK; YUNIS, AA	1
HANCK, A; KUTSCHER, W	1
Binz, T; Brose, N; Matti, U; Nagy, G; Neher, E; Reim, K; Rettig, J; Sørensen, JB	1
Lamparter, T; Michael, N	1
Barbosa, S; Barrish, JC; Bhide, RS; Borzilleri, RM; Cai, ZW; Chao, S; D'Arienzo, C; Derbin, G; Fargnoli, J; Fura, A; Hunt, JT; Jeyaseelan, R; Kamath, A; Kim, SH; Kukral, D; Leavitt, K; Leith, L; Lombardo, LJ; Marathe, P; Mathur, A; Mortillo, S; Qian, L; Vyas, V; Wautlet, B; Wei, D; Wu, LI; Zhang, YZ; Zheng, X	1
Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Young, RJ; Zhou, P	1
Awada, M; Bautista, A; Gardner, JL; Hellerstein, MK; Lindwall, G; Turner, SM	1
Bando, T; Fujimoto, J; Kashiwazaki, G; Minoshima, M; Murakami, M; Nakazono, S; Ohtsuki, A; Sasaki, S; Shinohara, K; Sugiyama, H	1
Barbosa, S; Barrish, JC; Bhide, RS; Borzilleri, RM; Cai, ZW; D'Arienzo, C; Derbin, G; Fan, J; Fargnoli, J; Hunt, JT; Jeyaseelan, R; Kamath, A; Kukral, DW; Lombardo, LJ; Marathe, P; Mortillo, S; Qian, L; Robl, JA; Shi, Z; Wautlet, BS; Wei, D; Wu, L; Zhang, Y; Zheng, X	1
Gröhn, F; Klein, K; Rehm, T; Schmuck, C; Stepanenko, V; Würthner, F; Zhang, X	1
Bhide, R; D'Arienzo, C; Fargnoli, J; Kamath, AV; Marathe, PH; Zhang, Y	1
Dörr, AA; Lubell, WD	1
Brandsch, M; Geissler, S; Hellwig, M; Henle, T; Knütter, I; Peto, A	1
Barrish, JC; Bhide, RS; Cai, ZW; Fargnoli, J; Galbraith, S; Henley, BJ; Hunt, JT; Jeyaseelan, R; Krishnan, B; Kukral, D; Lewin, AC; Lombardo, LJ; Malone, H; Mortillo, S; Wautlet, BS	1
Brandsch, M; Geissler, S; Hellwig, M; Henle, T; Markwardt, F; Zwarg, M	1
Fargnoli, J; Jordan, VC; Kim, HR; Klein-Szanto, AJ; Li, T; Oseni, S; Patel, RR; Pyle, JR; Ross, EA; Sengupta, S; Zhu, F	1
de Ávila Miguel, T; Falcão, VC; Hirooka, EY; Ono, EY; Ono, MA; Vizoni, E	1
Colombo, M; Mazzoleni, M; Saliu, F; Tremolada, P; Vighi, M	1
Fischer, BS; Gan, J; Ganapathi, R; Gong, J; Iyer, R; Masson, E; Mekhail, T; Patricia, D; Pursley, J; Williams, D	1
Dempke, WC; Zippel, R	1
Baudelet, C; Finn, RS; Harris, R; Ismail, F; Karwal, M; Kim, JS; Li, RK; Park, JW; Raoul, JL; Thomas, M; Walters, I	1
Diaz-Padilla, I; Siu, LL	1
Acoca, S; Cui, Q; Purisima, EO; Shore, GC	1
Abbas, A; Jones, H; Kingston, GT; Zurek, A	1
Chen, CR; Kodra, JT; Liu, X; Yu, R	1
Chang, AY; Wang, M	1
Bello, E; Berndt, A; Camboni, G; Cavalletti, E; Colella, G; D'Incalci, M; Damia, G; Forestieri, D; Giavazzi, R; Licandro, SA; Richter, P; Taraboletti, G; Zucchetti, M	1
Asamitsu, S; Bando, T; Hashiya, K; Kawamoto, Y; Nagase, H; Sugiyama, H; Takenaka, T; Taylor, RD; Yamamoto, M	1
Bashkin, JK; Dupureur, CM; Harris, GD; He, G; Koeller, KJ; Vasilieva, E	1
Kalyan, A; Kulik, L; Nimeiri, H	1
García-González, MC; Gordillo-Cruz, RE; Hernández-Vázquez, E; Miranda, LD	1
Andrade, CG; Bordini, JG; Hirooka, EY; Miguel, Tde Á; Ono, EY; Ono, MA; Saito, GH; Vizoni, É	1
Meijide, F; Pérez Coll, C; Svartz, G	1
Budisa, N; Durkin, P; Hoesl, MG; Kuthning, A; Oehm, S; Süssmuth, RD	1
Camargo, C; Giesler, LJ; Hunt, TE; Siegfried, BD	1
Acquaroni, M; Pérez Coll, C; Svartz, G	1
Eto, T; Ichida, T; Kusano, F; Sakai, Y; Ueyama, S	1
Gong, W; Han, P; Hu, B; Jiang, M; Li, B; Liang, G; Zhang, T; Zhang, W	1
Adiga, G; Alicai, T; Balmer, A; Cortes, DFM; de Freitas, JPX; de Oliveira, EJ; de Oliveira, SAS; Klauser, D; Liri, C; Otto, C; Pariyo, A; Robinson, M	1
Alvarez, JC; Annane, D; Etting, I; Larabi, IA; Moine, P	1
Bunel, V; Descamps, D; Jaquet, P; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Bunel, V; Descamps, D; Jaquet, P; Le Beller, C; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH	1
Muller, FL; Yan, VC	1
Cies, JJ; Davis, MR; Pham, CU	1
Arnold, L; Chernobrovkin, A; Friman, T; Martinez Molina, D	1
Chen, YS; Chu, J; German, P; Humeniuk, R; John Ling, KH; Mathias, A; Tarnowski, T; van Ingen, E; Xiao, D	1
Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M	1
Bojkova, D; Buyck, C; Ciesek, S; Cinatl, J; De Jonghe, S; De Meyer, S; Jochmans, D; Leyssen, P; Neyts, J; Van Damme, E; Van Loock, M	1
Babusis, D; Cao, H; German, P; Humeniuk, R; Kirby, BJ; Ling, J; Lutz, JD; Mathias, A; Osinusi, A; Porter, D; Reddy, YS; Wei, X	1
Gandhi, M; Gerona, R; Metcalfe, J; Ong, CM; Reckers, A; Wu, AHB	1
Abe, T; Maekawa, M; Mano, N; Sato, T; Yamaguchi, H	1
Deb, S; Reeves, AA	1
Fenyvesi, É; Hirka, G; Puskás, I; Renkecz, T; Sirok, D; Sohajda, T; Stáhl, J; Szente, L	1
Agrati, C; Ascoli Bartoli, T; Benvenuto, D; Marchioni, L; Nicastri, E; Stazi, GV; Tempestilli, M	1

Reviews

5 review(s) available for alanine and pyrroles

Article	Year
Mechanism and control of pyrrole synthesis. Vitamins and hormones, 1968, Volume: 26 Topics: Alanine; Amino Acids; Autoradiography; Carbon Isotopes; Centrifugation, Density Gradient; Hydro-Lyases; Keto Acids; Levulinic Acids; Metals; Oxidation-Reduction; Potassium; Pyrroles; Rhodopseudomonas	1968
Brivanib, a novel dual VEGF-R2/bFGF-R inhibitor. Anticancer research, 2010, Volume: 30, Issue:11 Topics: Alanine; Clinical Trials as Topic; Humans; Neoplasms; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Triazines; Vascular Endothelial Growth Factor Receptor-2	2010
Brivanib alaninate for cancer. Expert opinion on investigational drugs, 2011, Volume: 20, Issue:4 Topics: Alanine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Triazines; Vascular Endothelial Growth Factor Receptor-2	2011
Systemic therapy of hepatocellular carcinoma: current and promising. Clinics in liver disease, 2015, Volume: 19, Issue:2 Topics: Alanine; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Combined Modality Therapy; Hepatectomy; Humans; Indoles; Liver Neoplasms; Liver Transplantation; Niacinamide; Phenylurea Compounds; Preoperative Care; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases; Triazines	2015
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor. Clinical pharmacokinetics, 2021, Volume: 60, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines	2021

Trials

3 trial(s) available for alanine and pyrroles

Article	Year
Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:11 Topics: Administration, Oral; Aged; Alanine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Feces; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Pyrroles; Triazines	2010
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-01, Volume: 17, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Humans; Liver Neoplasms; Male; Middle Aged; Pyrroles; Treatment Outcome; Triazines; Tumor Burden	2011
Randomized Controlled Trial Comparing the Effects of Vonoprazan Plus Rebamipide and Esomeprazole Plus Rebamipide on Gastric Ulcer Healing Induced by Endoscopic Submucosal Dissection. Internal medicine (Tokyo, Japan), 2019, Jan-15, Volume: 58, Issue:2 Topics: Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopic Mucosal Resection; Esomeprazole; Female; Humans; Male; Middle Aged; Proton Pump Inhibitors; Pyrroles; Quinolones; Severity of Illness Index; Stomach Neoplasms; Stomach Ulcer; Sulfonamides; Wound Healing	2019

Other Studies

63 other study(ies) available for alanine and pyrroles

Article	Year
Catabolic path of arginine and NAD regeneration in the parasite Fasciola hepatica. Comparative biochemistry and physiology. B, Comparative biochemistry, 1975, Jun-15, Volume: 51, Issue:2 Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Radioisotopes; Carboxylic Acids; Cytosol; Dogs; Fasciola hepatica; Glutamates; Ketoglutaric Acids; Mitochondria; NAD; Ornithine-Oxo-Acid Transaminase; Oxidoreductases Acting on CH-NH Group Donors; Proline; Pyrroles; Pyruvates; Urea	1975
Induction of immunogenicity of monoclonal antibodies by conjugation with drugs. Cancer research, 1991, Oct-15, Volume: 51, Issue:20 Topics: Alanine; Animals; Antibodies, Monoclonal; ErbB Receptors; Ether; Immunotoxins; Pyrroles; Vinblastine	1991
[A selective strain of Streptomyces albus var. metamycinus JA 3626 (Bradler a. Thrum) producing DL-alanine and a prodigiosin-like pigment]. Zeitschrift fur allgemeine Mikrobiologie, 1969, Volume: 9, Issue:1 Topics: Alanine; Anti-Bacterial Agents; Chromatography, Paper; Culture Media; Dactinomycin; Fermentation; Genetics, Microbial; Microscopy, Electron; Mutation; Paromomycin; Pigments, Biological; Prodigiosin; Pyrroles; Spores; Streptomyces	1969
Effect of 1-(2-carboxy-3-chlorophenyl)pyrrole on carbohydrate metabolism in rat and mouse. Biochemical pharmacology, 1974, Nov-15, Volume: 23, Issue:22 Topics: Alanine; Animals; Benzoates; Blood Glucose; Carbon Radioisotopes; Deoxyglucose; Diaphragm; Gluconeogenesis; Glucose; Hypoglycemic Agents; Kidney; Lactates; Liver; Male; Mice; Mice, Inbred ICR; Nephrectomy; Oxidation-Reduction; Perfusion; Pyrroles; Pyruvates; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors	1974
Inhibition of DNA and RNA polymerases of oncornaviruses and of bacteria by N-formyl-glycyl and N-formyl-alanyl derivatives of distamycin A. Pharmacological research communications, 1974, Volume: 6, Issue:4 Topics: Alanine; Amidines; Anti-Bacterial Agents; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; DNA Nucleotidyltransferases; DNA-Directed RNA Polymerases; Escherichia coli; Formates; Friend murine leukemia virus; Glycine; Oligopeptides; Proteins; Pyrroles; Splenic Neoplasms; Sucrose; Templates, Genetic; Tritium	1974
Amino acid inhibition of a 1 -pyrroline-5-carboxylate dehydrogenase preparation from beef kidney mitochondria. Biochemical and biophysical research communications, 1972, Oct-06, Volume: 49, Issue:1 Topics: Alanine; Amino Acid Oxidoreductases; Amino Acids; Animals; Cattle; Glutamates; Glycine; Kidney; Leucine; Mitochondria; Pyrroles; Serine; Valine	1972
Induction of pigmentation in nonproliferating cells of Serratia marcescens by addition of single amino acids. Journal of bacteriology, 1971, Volume: 106, Issue:2 Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Aspartic Acid; Bacteriological Techniques; Caseins; Culture Media; Filtration; Glutamates; Ornithine; Pigments, Biological; Prodigiosin; Proline; Protein Hydrolysates; Pyrroles; Serine; Serratia marcescens; Stereoisomerism; Temperature	1971
Beta-pyrrolo-L-alanine, a new antimetabolite of phenylalanine and tyrosine in Escherichia coli. Experientia, 1966, Dec-15, Volume: 22, Issue:12 Topics: Alanine; Antimetabolites; Chemistry, Organic; Escherichia coli; Organic Chemistry Phenomena; Phenylalanine; Pyrroles; Tryptophan; Tyrosine	1966
[N-(3,5-dicarboxy-4-methyl-2-pyrrolylcarbonyl) amino acids as possible substrates of prolinase]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1970, Volume: 351, Issue:1 Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry; Dipeptidases; Dipeptides; Esters; Glutamates; Glycine; Phenylalanine; Pyrroles; Tryptophan	1970
[Synthesis and activity of substituted 5-aryl-2-pyrrolidinones(DL)]. Il Farmaco; edizione scientifica, 1971, Volume: 26, Issue:5 Topics: Alanine; Anticonvulsants; Furans; Phenols; Pyrroles; Pyrrolidinones	1971
The biosynthesis of proline by Tetrahymena pyriformis. Biochimica et biophysica acta, 1967, Nov-28, Volume: 148, Issue:2 Topics: Acids; Alanine; Arginine; Carbon Isotopes; Citrulline; Glutamates; Hot Temperature; Hydrogen-Ion Concentration; Hydrolases; Ketoglutaric Acids; Kinetics; Metals; Ornithine; Oxidoreductases; Proline; Protein Denaturation; Pyrroles; Tetrahymena; Transaminases; Ureohydrolases; Valine	1967
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase. Archives of biochemistry and biophysics, 1995, Oct-20, Volume: 323, Issue:1 Topics: Alanine; Humans; Hydrolysis; Kinetics; Leukocyte Elastase; Leukocytes; Pancreatic Elastase; Pyrroles; Substrate Specificity	1995
Feed-back inhibition of oxidative stress by oxidized lipid/amino acid reaction products. Biochemistry, 1997, Dec-16, Volume: 36, Issue:50 Topics: Alanine; Aldehydes; Amino Acids; Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxytoluene; Copper; Dihydropyridines; Feedback; Ferric Compounds; Free Radical Scavengers; Hydrogen Peroxide; Microsomes; Molecular Structure; Muscles; Oncorhynchus mykiss; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances	1997
Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide. Journal of the American Chemical Society, 2002, Mar-13, Volume: 124, Issue:10 Topics: Alanine; Cross-Linking Reagents; DNA; Intercalating Agents; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles	2002
Characterization of overoxidized polypyrrole colloids imprinted with L-lactate and their application to enantioseparation of amino acids. Analytical chemistry, 2002, Aug-15, Volume: 74, Issue:16 Topics: Alanine; Amino Acids; Biosensing Techniques; Colloids; Electrochemistry; Lactic Acid; Oxidation-Reduction; Polymers; Pyrroles; Stereoisomerism	2002
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists. Molecular pharmacology, 2003, Volume: 64, Issue:2 Topics: Alanine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Isradipine; Phenylalanine; Point Mutation; Protein Subunits; Pyrroles; Rats; Repetitive Sequences, Nucleic Acid; Serine	2003
AMINO ACID TRANSPORT IN BLOOD CELLS. II. PATTERNS OF TRANSPORT OF SOME AMINO ACIDS IN MAMMALIAN RETICULOCYTES AND MATURE RED BLOOD CELLS. The Journal of laboratory and clinical medicine, 1965, Volume: 66 Topics: Adenosine Triphosphatases; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Benzoates; Biological Transport; Blood Cells; Erythrocytes; Ethylmaleimide; Glycine; Histidine; Ion Transport; Lysine; Pharmacology; Potassium; Puromycin; Pyrroles; Rats; Research; Reticulocytes; Sodium	1965
[ON THE SYNTHESIS OF 3-(PYRROLYL-(2))-ALANINE]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1964, Volume: 338 Topics: Alanine; Chemistry, Pharmaceutical; Pharmacy; Pyrroles; Research	1964
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron, 2004, Feb-05, Volume: 41, Issue:3 Topics: Alanine; Animals; Blotting, Western; Calcineurin; Calcium; Carbazoles; Carrier Proteins; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Exocytosis; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Kidney; Membrane Potentials; Membrane Proteins; Models, Biological; Mutation; Nerve Tissue Proteins; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Photolysis; Pyrethrins; Pyrroles; Secretory Vesicles; Synaptosomal-Associated Protein 25; Threonine; Time Factors; Transfection	2004
Agrobacterium phytochrome as an enzyme for the production of ZZE bilins. Biochemistry, 2005, Jun-14, Volume: 44, Issue:23 Topics: Agrobacterium tumefaciens; Alanine; Amino Acid Substitution; Bacterial Proteins; Bile Pigments; Biliverdine; Chromatography, High Pressure Liquid; Cysteine; Isomerism; Light; Methanol; Photochemistry; Photoreceptors, Microbial; Phycobilins; Phycocyanin; Phytochrome; Protein Kinases; Protein Processing, Post-Translational; Pyrroles; Spectrophotometry, Ultraviolet; Tetrapyrroles	2005
Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Alanine; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Triazines; Vascular Endothelial Growth Factor Receptor-2	2006
Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs. Bioorganic & medicinal chemistry letters, 2006, Dec-01, Volume: 16, Issue:23 Topics: Alanine; Amides; Anticoagulants; Antithrombin III; Binding Sites; Crystallography, X-Ray; Drug Design; Factor Xa; Models, Molecular; Molecular Structure; Pyrroles; Structure-Activity Relationship	2006
Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions. American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6 Topics: Administration, Oral; Alanine; Animals; Atorvastatin; Carbon Tetrachloride; Collagen; Deuterium Oxide; Drug Evaluation, Preclinical; Enalapril; Gas Chromatography-Mass Spectrometry; Griseofulvin; Heptanoic Acids; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rosiglitazone; Species Specificity; Thiazolidinediones; Time Factors	2007
Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition. Bioorganic & medicinal chemistry, 2008, Mar-01, Volume: 16, Issue:5 Topics: Alanine; Alkylation; Base Pairing; Base Sequence; DNA; Imidazoles; Pyrroles; Temperature	2008
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth fa Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6 Topics: Administration, Oral; Alanine; Animals; Biological Availability; Carcinoma; Cell Proliferation; Clinical Trials, Phase II as Topic; Drug Design; Drug Evaluation, Preclinical; Humans; Intestines; Liver; Lung Neoplasms; Mice; Microsomes; Molecular Structure; Prodrugs; Protein Kinase Inhibitors; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Solubility; Stereoisomerism; Triazines; Vascular Endothelial Growth Factor Receptor-2; Water; Xenograft Model Antitumor Assays	2008
A new type of soft vesicle-forming molecule: an amino acid derived guanidiniocarbonyl pyrrole carboxylate zwitterion. Organic letters, 2008, Apr-03, Volume: 10, Issue:7 Topics: Alanine; Carboxylic Acids; Guanidine; Models, Molecular; Molecular Structure; Pyrroles; Stereoisomerism	2008
Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate. Cancer chemotherapy and pharmacology, 2009, Volume: 65, Issue:1 Topics: Administration, Oral; Alanine; Animals; Antineoplastic Agents; Biological Availability; Brain; Caco-2 Cells; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Injections, Intravenous; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prodrugs; Pyrroles; Rats; Solubility; Tissue Distribution; Triazines; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2009
Synthesis and peptide coupling of protected pyrrolylalanine. Advances in experimental medicine and biology, 2009, Volume: 611 Topics: Alanine; Peptides; Pyrroles	2009
Transport of free and peptide-bound pyrraline at intestinal and renal epithelial cells. Journal of agricultural and food chemistry, 2009, Jul-22, Volume: 57, Issue:14 Topics: Alanine; Amino Acid Transport Systems; Animals; Biological Transport; Caco-2 Cells; Cell Line; Dipeptides; Epithelial Cells; Humans; Intestinal Mucosa; Kidney; Kidney Tubules, Proximal; Lysine; Norleucine; Opossums; Peptides; Pyrroles; Rats	2009
The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases. Molecular cancer therapeutics, 2010, Volume: 9, Issue:2 Topics: Alanine; Animals; Antigens, CD34; Cell Line, Tumor; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Laminin; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Proteoglycans; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Time Factors; Triazines; Vascular Endothelial Growth Factor Receptor-2	2010
Transport of the advanced glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1. Journal of agricultural and food chemistry, 2010, Feb-24, Volume: 58, Issue:4 Topics: Alanine; Animals; Biological Transport; Dipeptides; DNA, Complementary; Genetic Vectors; Glycation End Products, Advanced; HeLa Cells; Humans; Intestinal Mucosa; Magnetic Resonance Spectroscopy; Maillard Reaction; Norleucine; Oocytes; Peptide Transporter 1; Pyrroles; Restriction Mapping; Symporters; Transfection; Xenopus laevis	2010
Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors. European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:9 Topics: Alanine; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Random Allocation; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Transplantation, Heterologous; Triazines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Fusarium verticillioides: evaluation of fumonisin production and effect of fungicides on in vitro inhibition of mycelial growth. Mycopathologia, 2011, Volume: 171, Issue:1 Topics: Alanine; Culture Media; Dioxoles; Fumonisins; Fungicides, Industrial; Fusarium; Mycelium; Nitrobenzenes; Pyrroles; Zea mays	2011
Field trial for evaluating the effects on honeybees of corn sown using Cruiser and Celest xl treated seeds. Bulletin of environmental contamination and toxicology, 2010, Volume: 85, Issue:3 Topics: Agriculture; Alanine; Animals; Bees; Dioxoles; Environmental Exposure; Insecticides; Lethal Dose 50; Neonicotinoids; Nitro Compounds; Oxazines; Pyrroles; Seeds; Thiamethoxam; Thiazoles; Zea mays	2010
Molecular dynamics study of small molecule inhibitors of the Bcl-2 family. Proteins, 2011, Volume: 79, Issue:9 Topics: Alanine; Amino Acid Sequence; Biphenyl Compounds; Humans; Indoles; Molecular Conformation; Molecular Dynamics Simulation; Molecular Sequence Data; Nitrophenols; Piperazines; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sequence Alignment; Sulfonamides; Thermodynamics	2011
Malignant peripheral nerve sheath tumour presenting as a pneumothorax. The British journal of radiology, 2011, Volume: 84, Issue:1006 Topics: Adult; Alanine; Antineoplastic Agents; Fatal Outcome; Humans; Male; Nerve Sheath Neoplasms; Peripheral Nervous System Neoplasms; Pneumothorax; Pyrroles; Radiography, Thoracic; Triazines	2011
Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones. Journal of molecular endocrinology, 2012, Volume: 49, Issue:2 Topics: Alanine; Asparagine; Cell Membrane; Curcumin; Cyclic AMP; Drug Design; Glucagon; Green Fluorescent Proteins; HEK293 Cells; Humans; Molecular Chaperones; Mutation; Pancreatic Neoplasms; Protein Transport; Pyridines; Pyrroles; Receptors, Glucagon; Serine; Thapsigargin	2012
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma. Anti-cancer drugs, 2013, Volume: 24, Issue:3 Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines	2013
The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Molecular cancer therapeutics, 2013, Volume: 12, Issue:2 Topics: Alanine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Synergism; Female; Humans; Indoles; Mice; Mice, Nude; Paclitaxel; Protein Kinase Inhibitors; Pyrroles; Rabeprazole; Random Allocation; Sunitinib; Triazines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2013
Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates. Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Jan-27, Volume: 20, Issue:5 Topics: Alanine; Alkylation; Base Pairing; Base Sequence; Codon; DNA; Humans; Imidazoles; Models, Molecular; Mutation; Nylons; Pyrroles; ras Proteins	2014
Binding studies of a large antiviral polyamide to a natural HPV sequence. Biochimie, 2014, Volume: 102 Topics: Alanine; Antiviral Agents; Binding Sites; DNA; Human papillomavirus 16; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles	2014
Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles. Chemical communications (Cambridge, England), 2015, Jul-25, Volume: 51, Issue:58 Topics: Alanine; Benzylamines; Catalysis; Indoles; Isoquinolines; Palladium; Pyrroles	2015
Effect of fungicide on Fusarium verticillioides mycelial morphology and fumonisin B₁ production. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2015, Volume: 46, Issue:1 Topics: Alanine; Dioxoles; Fumonisins; Fungicides, Industrial; Fusarium; Hyphae; Microscopy, Electron, Scanning; Pyrroles; Spores, Fungal	2015
Effects of a fungicide formulation on embryo-larval development, metamorphosis, and gonadogenesis of the South American toad Rhinella arenarum. Environmental toxicology and pharmacology, 2016, Volume: 45 Topics: Alanine; Animals; Bufonidae; Dioxoles; Embryo, Nonmammalian; Embryonic Development; Female; Fungicides, Industrial; Gonads; Larva; Male; Metamorphosis, Biological; Pyrroles; Water Pollutants, Chemical	2016
Towards Biocontained Cell Factories: An Evolutionarily Adapted Escherichia coli Strain Produces a New-to-nature Bioactive Lantibiotic Containing Thienopyrrole-Alanine. Scientific reports, 2016, 09-16, Volume: 6 Topics: Adaptation, Physiological; Alanine; Amino Acid Sequence; Anti-Infective Agents; Bacteriocins; Biological Evolution; Escherichia coli; Microbial Sensitivity Tests; Peptides; Pyrroles; Ribosomes; Spectrometry, Mass, Electrospray Ionization	2016
Thiamethoxam Toxicity and Effects on Consumption Behavior in Orius insidiosus (Hemiptera: Anthocoridae) on Soybean. Environmental entomology, 2017, 06-01, Volume: 46, Issue:3 Topics: Alanine; Anilides; Animals; Aphids; Dioxoles; Fungicides, Industrial; Glycine max; Heteroptera; Insecticides; Neonicotinoids; Nitro Compounds; Oxazines; Predatory Behavior; Pyrazoles; Pyrroles; Thiamethoxam; Thiazoles	2017
Differential sensitivity of developmental stages of the South American toad to a fungicide based on fludioxonil and metalaxyl-M. Environmental science and pollution research international, 2018, Volume: 25, Issue:24 Topics: Alanine; Animals; Blastula; Bufo arenarum; Dioxoles; Dose-Response Relationship, Drug; Ecotoxicology; Embryo, Nonmammalian; Female; Fungicides, Industrial; Larva; Mortality; Pyrroles; Toxicity Tests, Chronic	2018
Uptake and dissipation of metalaxyl-M, fludioxonil, cyantraniliprole and thiamethoxam in greenhouse chrysanthemum. Environmental pollution (Barking, Essex : 1987), 2020, Volume: 257 Topics: Alanine; Chrysanthemum; Dioxoles; Fungicides, Industrial; Guanidines; Humans; Insecticides; Neonicotinoids; ortho-Aminobenzoates; Pesticide Residues; Pesticides; Pyrazoles; Pyrroles; Soil; Soil Pollutants; Thiamethoxam; Thiazoles	2020
A novel seed treatment-based multiplication approach for cassava planting material. PloS one, 2020, Volume: 15, Issue:3 Topics: Alanine; Dioxoles; Latex; Manihot; Plant Breeding; Plant Stems; Pyrroles; Seeds; Thiabendazole; Thiamethoxam	2020
Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient. Clinical chemistry and laboratory medicine, 2020, 08-27, Volume: 58, Issue:9 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chromatography, Liquid; Coronavirus Infections; COVID-19; Drug Monitoring; Drug Stability; Female; Furans; Humans; Limit of Detection; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrroles; Reproducibility of Results; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2020
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19. Antimicrobial agents and chemotherapy, 2020, 10-20, Volume: 64, Issue:11 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Furans; Humans; Intensive Care Units; Lung Transplantation; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity". Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung Transplantation; Neuroglia; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrobial agents and chemotherapy, 2020, 11-17, Volume: 64, Issue:12 Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines	2020
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis. The Journal of antimicrobial chemotherapy, 2021, 02-11, Volume: 76, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Furans; Humans; Kidney Failure, Chronic; Pyrroles; Renal Dialysis; Triazines	2021
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target. SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; ATPases Associated with Diverse Cellular Activities; Cell Cycle Proteins; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Furans; Hep G2 Cells; Humans; Mass Spectrometry; Proteomics; Pyrroles; Triazines; United States; United States Food and Drug Administration	2021
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies. Analytical biochemistry, 2021, 03-15, Volume: 617 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Furans; Humans; Limit of Detection; Pyrroles; Tandem Mass Spectrometry; Triazines	2021
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum Journal of pharmaceutical and biomedical analysis, 2021, Mar-20, Volume: 196 Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
In vitro activity of itraconazole against SARS-CoV-2. Journal of medical virology, 2021, Volume: 93, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Repositioning; Furans; Humans; Itraconazole; Pyrroles; SARS-CoV-2; Triazines; Vero Cells; Virus Replication	2021
A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum. The Journal of antimicrobial chemotherapy, 2021, 06-18, Volume: 76, Issue:7 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Dexamethasone; Furans; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Triazines	2021
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Dogs; Dose-Response Relationship, Drug; Drug Approval; Furans; Humans; Kidney; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Pyrroles; Triazines	2021
Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2021, Volume: 24 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Computer Simulation; COVID-19; COVID-19 Drug Treatment; Databases, Chemical; Drug Interactions; Furans; Humans; Prodrugs; Pyrroles; Risk Assessment; Risk Factors; SARS-CoV-2; Triazines	2021
Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits. International journal of pharmaceutics, 2022, May-25, Volume: 620 Topics: Adenosine Monophosphate; Administration, Buccal; Administration, Intravenous; Alanine; Animals; Antiviral Agents; Biological Availability; COVID-19 Drug Treatment; Furans; Humans; Pyrroles; Rabbits; SARS-CoV-2; Triazines	2022
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects. The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Transaminases; Triazines	2022