alanine has been researched along with pyrimidinones in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 20 (60.61) | 29.6817 |
| 2010's | 5 (15.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC | 1 |
| Clifford, DB; Thio, LL; Zorumski, CF | 1 |
| Ashworth, TS; Brown, EG; Roberts, FM | 1 |
| Jane, DE; Mayer, ML; Watkins, JC; Wong, LA | 1 |
| Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM | 1 |
| Bowie, D; Smart, TG | 1 |
| Beart, PM; Ganakas, AM; Lawrence, AJ; Lunn, ML; Mercer, LD | 1 |
| Bleakman, D; Deverill, M; Hoo, K; Jane, DE; Kamboj, R; Mandelzys, A | 1 |
| Arai, AC; Kessler, M; Lynch, G; Rogers, G | 1 |
| Eisenstein, M; Hollmann, M; Kizelsztein, P; Strutz, N; Teichberg, VI | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Fukushima, T; Marshall, J; Sakata, K; Shingai, R | 1 |
| Ressler, C; Tatake, JG | 1 |
| Cagnotto, A; Campiani, G; Fattorusso, C; Fumagalli, E; Greenwood, J; Griffiths, R; Kristensen, AS; Liljefors, T; Mennini, T; Morelli, E; Nacci, V; Novellino, E; Pickering, DS; Ramunno, A; Reavy, H; Schousboe, A; Sinclair, C | 1 |
| Jane, DE; More, JC; Troop, HM | 1 |
| Campiani, G; Grieve, A; Griffiths, R; Morelli, E; Novellino, E; Reavy, H; Schousboe, A; Sinclair, C | 1 |
| Dolman, NP; Jane, DE; More, JC; Troop, HM | 1 |
| Gouaux, E; Jin, R | 1 |
| Banke, TG; Gouaux, E; Jin, R; Mayer, ML; Traynelis, SF | 1 |
| Fukushima, T; Ichinose, M; Ogurusu, T; Shingai, R | 1 |
| Alt, A; Bleakman, D; Bortolotto, ZA; Collingridge, GL; Dolman, NP; Jack, S; Jane, DE; Knauss, JL; More, JC; Morley, RM; Nistico, R; Roberts, PJ; Troop, HM | 1 |
| Alt, A; Bleakman, D; Collingridge, GL; Dolman, NP; Jane, DE; Knauss, JL; More, JC; Troop, HM | 1 |
| Allan, RD; Greenwood, JR; Martín, BO; Mewett, KN; Pickering, DS | 1 |
| Carmeliet, P; Fontaine, RH; Gallego, J; Gressens, P; Hicklin, DJ; Laudenbach, V; Leroux, P; Marret, S; Medja, F | 1 |
| Alt, A; Bleakman, D; Collingridge, GL; Dolman, NP; Glasser, CR; Jane, DE; Knauss, JL; Mayer, ML; More, JC; Pentikäinen, OT | 1 |
| Jayaraman, V; Mankiewicz, KA; Rambhadran, A; Wathen, L | 1 |
| Fenwick, MK; Oswald, RE | 1 |
| Brynda, J; Kagan, RM; Konvalinka, J; Kozísek, M; Lepsík, M; Machala, L; Rezácová, P; Sasková, KG; Václavíková, J | 1 |
| Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M | 1 |
| Eagen, KP; Ganem, B; Hess, GP; Lewis, RW; Mabry, J; Polisar, JG | 1 |
| Finn, R; Kovács, AD; Pearce, DA | 1 |
| Seifi, M; Swinny, JD | 1 |
| Anslyn, EV; Dedkova, LM; Ellington, AD; Hecht, SM; Lim, J; Talukder, P; Yakovchuk, P | 1 |
33 other study(ies) available for alanine and pyrimidinones
| Article | Year |
|---|---|
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil | 1992 |
Effects of bromowillardiine and willardiine on non-N-methyl-D-aspartate receptors in postnatal rat hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Membrane Potentials; Neurons; Pyrimidinones; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Uracil | 1991 |
Biosynthesis of willardiine and isowillardiine in germinating pea seeds and seedlings.
Topics: Alanine; Carbon Isotopes; Chromatography, Ion Exchange; Light; Orotic Acid; Pyrimidinones; Seeds; Structure-Activity Relationship; Thiouracil; Uracil | 1972 |
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil | 1994 |
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil | 1995 |
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis | 1993 |
Localisation and properties of AMPA-insensitive kainate sites: receptor autoradiography and gene expression in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Base Sequence; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Vitro Techniques; Male; Molecular Sequence Data; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Uracil | 1996 |
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Topics: Alanine; Cell Line; Excitatory Amino Acid Agonists; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Triazines; Uracil | 1997 |
Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466.
Topics: Alanine; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cells, Cultured; Diuretics; Drug Interactions; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Male; Oxazines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Proteins; Sodium Chloride Symporter Inhibitors; Tritium; Uracil | 2000 |
Mutant cycle analysis of the active and desensitized states of an AMPA receptor induced by willardiines.
Topics: Alanine; Animals; Anura; Benzothiadiazines; Binding Sites; Dose-Response Relationship, Drug; Ion Channel Gating; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Pyrimidinones; Receptors, AMPA; Uracil | 2000 |
Interference of S-nitrosoglutathione with the binding of ligands to ionotropic glutamate receptors in pig cerebral cortical synaptic membranes.
Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Kainic Acid; Kinetics; Ligands; Neuroprotective Agents; Nitroso Compounds; Piperazines; Pyrimidinones; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Swine; Synaptic Membranes; Uracil | 2000 |
Calcium inhibits willardiine-induced responses in kainate receptor GluR6(Q)/KA-2.
Topics: Alanine; Calcium Chloride; Cells, Cultured; GluK2 Kainate Receptor; Humans; Kidney; Membrane Potentials; Pyrimidinones; Receptors, Kainic Acid; Uracil | 2001 |
Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat.
Topics: Alanine; Animals; Diet; Fabaceae; Glucosides; Male; Nitriles; Pyrimidinones; Rats; Rats, Sprague-Dawley; Seeds; Thiocyanates; Toxins, Biological; Weaning | 2001 |
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Topics: Alanine; Animals; Brain; Cell Death; Cell Line; Electrophysiology; Excitatory Amino Acid Agonists; In Vitro Techniques; Ligands; Mice; Models, Molecular; Neurons; Oocytes; Pyrimidines; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Recombinant Proteins; Stereoisomerism; Xenopus laevis | 2001 |
The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
Topics: Alanine; Animals; Animals, Newborn; Benzodiazepines; Benzyl Compounds; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Motor Neurons; Nerve Fibers; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Nerve Roots; Time Factors; Uracil | 2002 |
Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells.
Topics: Alanine; Animals; Calcium; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Excitatory Amino Acid Agonists; L-Lactate Dehydrogenase; Mice; Pyrimidinones; Receptors, AMPA | 2003 |
Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.
Topics: Alanine; Animals; Animals, Newborn; Drug Antagonism; Evoked Potentials; Molecular Conformation; Molecular Structure; Nerve Fibers, Unmyelinated; Pyrimidinones; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Cord; Spinal Nerve Roots; Structure-Activity Relationship; Uracil | 2003 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
Structural basis for partial agonist action at ionotropic glutamate receptors.
Topics: Alanine; Animals; Cell Line; Crystallography, X-Ray; Electric Conductivity; Electrophysiology; Humans; Ion Channels; Ligands; Models, Biological; Molecular Conformation; Oocytes; Pyrimidinones; Receptors, AMPA; Uracil; Xenopus laevis | 2003 |
Inhibition of willardiine-induced currents through rat GluR6/KA-2 kainate receptor channels by Zinc and other divalent cations.
Topics: Alanine; Animals; Barium; Binding, Competitive; Calcium; Cations, Divalent; Cell Line, Transformed; Dose-Response Relationship, Drug; GluK2 Kainate Receptor; Humans; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Pyrimidinones; Rats; Receptors, Kainic Acid; Uracil; Zinc | 2003 |
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Topics: Alanine; Animals; Animals, Newborn; Calcium; Cell Line; Humans; In Vitro Techniques; Long-Term Potentiation; Mossy Fibers, Hippocampal; Nerve Fibers, Unmyelinated; Protein Subunits; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Structure-Activity Relationship; Uracil | 2005 |
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Line; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Molecular Structure; Pyrimidinones; Rats; Receptors, Kainic Acid; Recombinant Proteins; Structure-Activity Relationship; Time Factors; Uracil | 2006 |
3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists.
Topics: Alanine; Animals; Carboxylic Acids; Cerebral Cortex; Cloning, Molecular; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Models, Molecular; Molecular Mimicry; Oocytes; Pyridazines; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Glutamate; Recombinant Proteins; RNA, Complementary; Structure-Activity Relationship; Uracil; Xenopus laevis | 2006 |
Neonatal hypoxic preconditioning involves vascular endothelial growth factor.
Topics: Aging; Alanine; Animals; Animals, Newborn; Antibodies, Blocking; Brain; Excitatory Amino Acid Agonists; Hypoxia, Brain; Ibotenic Acid; Injections, Intraperitoneal; Mice; Mice, Transgenic; Mutation; Promoter Regions, Genetic; Pyrimidinones; Recombinant Proteins; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Weight Loss | 2007 |
Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.
Topics: Alanine; Animals; Animals, Newborn; Binding Sites; Calcium; Cell Line; Crystallography, X-Ray; Humans; In Vitro Techniques; Ligands; Models, Molecular; Motor Neurons; Nerve Fibers, Unmyelinated; Protein Conformation; Pyrimidinones; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Nerve Roots; Stereoisomerism; Structure-Activity Relationship; Uracil | 2007 |
Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Protein Conformation; Protein Structure, Secondary; Pyrimidinones; Receptors, AMPA; Spectroscopy, Fourier Transform Infrared; Uracil | 2008 |
NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists.
Topics: Alanine; Binding Sites; Crystallography, X-Ray; Ligands; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Pyrimidinones; Receptors, AMPA; Uracil | 2008 |
Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.
Topics: Alanine; Amino Acid Substitution; Catalysis; Computational Biology; Disease Susceptibility; Drug Resistance, Viral; Escherichia coli; HIV Protease; HIV Protease Inhibitors; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Lopinavir; Models, Molecular; Protein Structure, Secondary; Pyrimidinones; Recombinant Proteins | 2008 |
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2010 |
Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.
Topics: Alanine; Allosteric Regulation; Cell Line; Drug Synergism; Epilepsy; Genetic Variation; Glutamic Acid; Humans; Mutagenesis, Site-Directed; Protein Binding; Protein Isoforms; Protein Subunits; Pyrimidines; Pyrimidinones; Receptors, GABA-A; Thiones | 2010 |
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Agonists; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Pyrimidinones; Receptors, Glutamate; Species Specificity | 2010 |
Immunolocalization of AMPA receptor subunits within the enteric nervous system of the mouse colon and the effect of their activation on spontaneous colonic contractions.
Topics: Alanine; Animals; Colon; Enteric Nervous System; Gastrointestinal Motility; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Protein Subunits; Pyrimidinones; Receptors, AMPA | 2016 |
Synthesis of alanyl nucleobase amino acids and their incorporation into proteins.
Topics: Alanine; Codon; DNA Polymerase I; Escherichia coli; Purines; Pyrimidinones; RNA, Messenger; RNA, Transfer; Tetrahydrofolate Dehydrogenase; Transfer RNA Aminoacylation | 2016 |