alanine has been researched along with phosphonoacetic acid in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cleland, WW; O'Leary, MH; Parmentier, LE; Schachman, HK; Turnbull, JL; Waldrop, GL | 1 |
| Kantrowitz, ER; Newton, CJ | 1 |
| Kantrowitz, ER; Xu, W | 1 |
| Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH | 1 |
| Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ | 1 |
| Creagan, ET; Kovach, JS; O'Connell, MJ | 1 |
| Koch, MR; Lea, MA | 1 |
| Kantrowitz, ER; Keiser, RT; Tauc, P; Vachette, P | 1 |
| Haigh, JR; Houben, K; Howard, BD; Ramachandran, B; Rozenberg, YY; Varpetian, A | 1 |
| Kafarski, P; Krzyśko-Lupicka, T; Kubś, K; Lejczak, B; Skorupa, M; Strof, W; Wieczorek, P | 1 |
| Chan, RS; Kantrowitz, ER; Macol, CP; Sakash, JB; Tsuruta, H; West, JM | 1 |
2 trial(s) available for alanine and phosphonoacetic acid
| Article | Year |
|---|---|
Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma.
Topics: Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cimetidine; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Melanoma; Middle Aged; Phosphonoacetic Acid; Pleural Neoplasms; Soft Tissue Neoplasms | 1987 |
Clinical trial of PALA and L-Alanosine in advanced colorectal carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Nausea; Phosphonoacetic Acid; Rectal Neoplasms; Stomatitis | 1983 |
9 other study(ies) available for alanine and phosphonoacetic acid
| Article | Year |
|---|---|
Steady-state kinetics and isotope effects on the mutant catalytic trimer of aspartate transcarbamoylase containing the replacement of histidine 134 by alanine.
Topics: Alanine; Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Carbon Isotopes; Catalysis; Histidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Macromolecular Substances; Models, Molecular; Mutation; Phosphonoacetic Acid; Recombinant Proteins; Structure-Activity Relationship; Succinates | 1992 |
Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.
Topics: Adenosine Triphosphate; Alanine; Allosteric Regulation; Aspartate Carbamoyltransferase; Aspartic Acid; Cytidine Triphosphate; Enzyme Activation; Escherichia coli; Kinetics; Mutation; Phosphonoacetic Acid; Succinates | 1990 |
Function of threonine-55 in the carbamoyl phosphate binding site of Escherichia coli aspartate transcarbamoylase.
Topics: Alanine; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Carbamyl Phosphate; Escherichia coli; Kinetics; Molecular Structure; Mutation; Phosphonoacetic Acid; Protein Conformation; Threonine | 1989 |
A Phase I study of the combination N-(phosphonacetyl)-L-aspartate (PALA, NSC-224131) and L-alanosine (NSC-153353) in patients with advanced cancer.
Topics: Alanine; Aspartic Acid; Diarrhea; Digestive System Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; Injections, Intravenous; Organophosphorus Compounds; Phosphonoacetic Acid; Stomatitis | 1983 |
Uptake of 14C-labeled dicarboxylic amino acids in hepatocytes and hepatoma cells.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Amino Acids, Dicarboxylic; Aminoisobutyric Acids; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Phosphonoacetic Acid; Rats; Sodium | 1981 |
Glu-50 in the catalytic chain of Escherichia coli aspartate transcarbamoylase plays a crucial role in the stability of the R quaternary structure.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Aspartate Carbamoyltransferase; Aspartic Acid; Enzyme Activation; Enzyme Stability; Escherichia coli; Glutamic Acid; Kinetics; Nucleotides; Phosphonoacetic Acid; Point Mutation; Protein Conformation; Scattering, Radiation; Succinates; Succinic Acid; X-Rays | 1994 |
Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; DNA, Complementary; Gene Expression; Glycine; Glycoproteins; Molecular Sequence Data; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oncogene Proteins; PC12 Cells; Phosphonoacetic Acid; RNA, Messenger; Symporters | 1993 |
The ability of soil-borne fungi to degrade organophosphonate carbon-to-phosphorus bonds.
Topics: Alanine; Aminoethylphosphonic Acid; Aspergillus niger; Bacteria, Aerobic; Bacteria, Anaerobic; Biodegradation, Environmental; Carbon; Environmental Pollutants; Fungi; Glycine; Glyphosate; Organophosphorus Compounds; Phosphonoacetic Acid; Phosphorus; Soil Microbiology; Species Specificity; Trichoderma | 1997 |
The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase.
Topics: Adenosine Triphosphate; Alanine; Allosteric Site; Aspartate Carbamoyltransferase; Aspartic Acid; Catalytic Domain; Chromatography, Ion Exchange; Cytidine Triphosphate; Enzyme Inhibitors; Escherichia coli; Ligands; Lysine; Models, Molecular; Mutation; Phosphonoacetic Acid; Protein Binding; Protein Structure, Tertiary; Scattering, Radiation; X-Rays | 2002 |