alanine and organophosphonates

alanine has been researched along with organophosphonates in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (19.30)	18.7374
1990's	5 (8.77)	18.2507
2000's	19 (33.33)	29.6817
2010's	18 (31.58)	24.3611
2020's	4 (7.02)	2.80

Authors

Authors	Studies
Horigane, A; Horiguchi, M; Matsumoto, T	1
Allen, JG; Atherton, FR; Hall, MJ; Hassall, CH; Holmes, SW; Lambert, RW; Nisbet, LJ; Ringrose, PS	1
Gilmore, F; Huber, JW; Robertson, LW	1
Jacobsen, JR; Kochersperger, L; Prudent, JR; Schultz, PG; Yonkovich, S	1
Duncan, K; Walsh, CT	1
Atherton, FR; Hassall, CH; Lambert, RW	1
Lacoste, AM; Neuzil, E	1
Roop, BL; Roop, WE; Tan, SA	1
Law, JH; Smith, JD	1
Diller, A; Schirch, LV	1
Bleiweis, AS; Krause, RM; Young, FE	1
Grünberger, D; Holý, A; Smrt, J; Sorm, F	1
Biggs, CS; Fowler, LJ; Maione, S; Whitton, PS	1
Bushell, TJ; Collingridge, GL; Garthwaite, J; Jane, DE; Tse, HW; Watkins, JC	1
Breyne, O; Carillon, S; Marquet, A; Ploux, O	1
Erni, B; Reymond, JL; Schenkels, C	1
Cihlar, T; Ho, ES; Lin, DC; Mendel, DB	1
Bearne, SL; St Maurice, M	1
Ballatore, C; Balzarini, J; De Clercq, E; McGuigan, C	1
Berman, HA; Kovarik, Z; Radić, Z; Reiner, E; Simeon-Rudolf, V; Taylor, P	1
Clark, T; Lanig, H; Schürer, G	1
Cole, PA; Klein, DC; Lebeau, A; Schwarzer, D; Weller, JL; Zheng, W	1
Cihlar, T; Cundy, KC; Eisenberg, E; He, GX; Lee, WA; Mulato, A; Swaminathan, S	1
Dang, Q; Erion, MD; Jiang, T; Kasibhatla, SR; Lipscomb, WN; Potter, SC; Reddy, KR; Reddy, MR; van Poelje, PD	1
Chandramouli, VC; Dang, Q; Erion, MD; Landau, BR; Potter, SC; van Poelje, PD	1
Bischofberger, N; Blackwood, EJ; Colón, R; Kearney, BP; Lawson, JR; Lee, WA; Marthas, ML; Sexton, JJ; Van Rompay, KK	1
Tomlinson, B; Wang, Y	1
Antipin, IS; Danila, DC; Hubble, H; Pinkhassik, E; Wang, X	1
Birkus, G; Cihlar, T; He, GX; Kutty, N; Lee, W; McDermott, M; Mulato, A	1
Holý, A; Otová, B; Votruba, I	1
Hrabálek, A; Janůsová, B; Kovaríková, P; Novotný, J; Novotný, M; Vávrová, K	1
Fujiwara, T; Hagisawa, Y; Izumi, M; Ohsumi, J; Okuno, A; Takahashi, K; Yoshida, T	1
Cole, PA; Szewczuk, LM; Tarrant, MK	1
Fujiwara, T; Hagisawa, Y; Kanda, S; Nakashima, R; Ogawa, J; Okuno, A; Takahashi, K; Tanaka, J; Yoshida, T	1
Chen, TY; Guga, P; Jayaram, M; Kachroo, AH; Ma, CH; Macieszak, A	1
Nishi, T; Okuno, A; Shiiki, T; Takagi, T; Takahashi, M; Tamaki, K; Tanaka, J; Tsukada, T; Yoshida, T	1
Lu, J; Xie, Z; Zhang, H; Zhang, WJ; Zhang, Y; Zhou, G	1
Froeyen, M; Herdewijn, P; Lescrinier, E; Marlière, P; Yang, S	1
Cashion, DK; Dang, Q; DaRe, J; Erion, MD; Fan, Y; Gibson, T; Jacintho, JD; Jiang, T; Kasibhatla, SR; Lemus, R; Li, H; Li, W; Liu, Y; Potter, SC; Sun, Z; Taplin, F; Tian, F; van Poelje, PD	1
Fujiwara, T; Hagisawa, Y; Kanda, S; Ogawa, J; Okuno, A; Takahashi, K; Yoshida, T	1
Carrothers, TJ; Habtemariam, B; Kastrissios, H; Khariton, T; Kshirsagar, S; Mager, DE; Rohatagi, S; Walker, JR	1
Erion, MD; Potter, SC; van Poelje, PD	1
Borysko, K; Breitenbach, J; Drach, JC; Hilfinger, J; Kashemirov, BA; Kijek, P; Kim, JS; McKenna, CE; Mitchell, S; Peterson, LW	1
Attwood, PV; Besant, PG; Byrne, LT; Flematti, GR; Mukai, S; Piggott, MJ	1
Berger, D; Bredeek, UF; Callebaut, C; DeJesus, E; Fordyce, MW; Markowitz, M; Ramanathan, S; Rhee, MS; Ruane, PJ; Yale, K; Zhong, L	1
Callebaut, C; Cao, H; Cheng, A; Crofoot, G; Custodio, J; Das, M; Flamm, JA; Gathe, J; Liu, HC; Martin, H; McCallister, S; McDonald, C; Mills, A; Saag, M; Scribner, A; Shalit, P; Shamblaw, D; Thomas, A; Yan, M	1
Baeten, JM; Wyatt, C	1
Andrade-Villanueva, J; Callebaut, C; Cao, H; Cheng, AK; Crofoot, G; Custodio, JM; DeJesus, E; Fordyce, MW; Koenig, E; Martin, H; McCallister, S; Molina, JM; Oka, S; Plummer, A; Podzamczer, D; Post, F; Pozniak, A; Saag, M; Sax, PE; Thompson, M; Trottier, B; Wohl, D; Yin, MT; Zhong, L	1
Beraud, G; Chagneau-Derrode, C; Garcia, M; Godet, C; Le Moal, G; Roblot, F	1
Ensign, LM; Hoang, T; Hummert, P; Marzinke, MA; Parsons, TL	1
Bensouda, S; Cone, RA; Date, AA; Ensign, LM; Fuchs, EJ; Gumber, S; Hanes, J; Hendrix, C; Hoang, T; Marzinke, M; Ortiz, JO; Rohan, L; Villinger, F; Xiao, P; Young, TW	1
de la Cruz, F; Giner-Robles, L; Lázaro, B; Moncalián, G	1
Hiraoka, A; Izumoto, H; Kitahata, S; Kondoh, K; Michitaka, K; Ninomiya, T; Tsubouchi, E; Ueki, H; Yamago, H	1
Hooi, B; Leungsuwan, S; Myint, KS	1
Ju, KS; Kayrouz, CM; Pham, TM; Zhang, Y	1
Asmuth, DM; Baeten, JM; Brainard, DM; Brunetta, JM; Carter, C; Cox, S; Das, M; Ebrahimi, R; Gilson, R; Henry, K; Kintu, A; Kronborg, G; Ogbuagu, O; Podzamczer, D; Ruane, PJ; Salazar, LC; Shao, Y; Spinner, CD; Whitlock, G; Wohl, D	1
Ahn, SH; Jung, CY; Kim, BS; Kim, HW; Kim, SU; Lee, HW; Lee, JI	1

Reviews

3 review(s) available for alanine and organophosphonates

Article	Year
Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Current opinion in investigational drugs (London, England : 2000), 2007, Volume: 8, Issue:10 Topics: Alanine; Animals; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Organophosphonates; Organophosphorus Compounds; Structure-Activity Relationship	2007
[Acyclic nucleoside phosphonates as potential antineoplastic agents]. Casopis lekaru ceskych, 2008, Volume: 147, Issue:9 Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines	2008
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handbook of experimental pharmacology, 2011, Issue:203 Topics: Alanine; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Humans; Hypoglycemic Agents; Organophosphonates; Organophosphorus Compounds; Signal Transduction	2011

Trials

4 trial(s) available for alanine and organophosphonates

Article	Year
Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4 Topics: Adenine; Adult; Alanine; Anti-Retroviral Agents; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nausea; Organophosphates; Organophosphonates; RNA, Viral; Single-Blind Method; Statistics, Nonparametric; Tenofovir; Viral Load; Young Adult	2013
Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate in the First Protease Inhibitor-Based Single-Tablet Regimen for Initial HIV-1 Therapy: A Randomized Phase 2 Study. Journal of acquired immune deficiency syndromes (1999), 2015, Aug-01, Volume: 69, Issue:4 Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; RNA, Viral; Tenofovir	2015
Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Lancet (London, England), 2015, Jun-27, Volume: 385, Issue:9987 Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Arthralgia; Bone Density; Carbamates; CD4 Lymphocyte Count; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; Headache; HIV Infections; Humans; Kidney; Male; Nausea; Organophosphonates; Quinolones; Respiration Disorders; Sleep Initiation and Maintenance Disorders; Tenofovir; Thiazoles; Treatment Outcome; Viral Load	2015
Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial. The lancet. HIV, 2021, Volume: 8, Issue:7 Topics: Adenine; Adult; Aged; Alanine; Anti-HIV Agents; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir; Treatment Outcome; Young Adult	2021

Other Studies

50 other study(ies) available for alanine and organophosphonates

Article	Year
Metabolism of 2-amino-3-phosphono[3-14C]propionic acid in cell-free preparations of rat liver. Biochimica et biophysica acta, 1979, May-01, Volume: 584, Issue:2 Topics: Alanine; Amino Acids; Animals; Cell-Free System; Liver; Organophosphonates; Organophosphorus Compounds; Phosphoenolpyruvate; Pyruvates; Rats	1979
Phosphonopeptides, a new class of synthetic antibacterial agents. Nature, 1978, Mar-02, Volume: 272, Issue:5648 Topics: Alanine; Alanine Racemase; Animals; Anti-Bacterial Agents; Bacteria; Cell Wall; Dipeptides; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Structure-Activity Relationship	1978
Synthesis and antimicrobial evaluation of N-D-alanyl-1-aminoethylphosphonic acid. Journal of medicinal chemistry, 1975, Volume: 18, Issue:1 Topics: Alanine; Anti-Bacterial Agents; Anti-Infective Agents; Aspergillus; Bacillus subtilis; Candida albicans; Escherichia coli; Ethylamines; Microbial Sensitivity Tests; Mycobacterium; Organophosphonates; Organophosphorus Compounds; Proteus vulgaris; Pseudomonas aeruginosa; Saccharomyces cerevisiae; Staphylococcus; Trichophyton	1975
An efficient antibody-catalyzed aminoacylation reaction. Science (New York, N.Y.), 1992, Apr-17, Volume: 256, Issue:5055 Topics: Acylation; Alanine; Amino Acyl-tRNA Synthetases; Antibodies, Monoclonal; Catalysis; Chromatography, High Pressure Liquid; Esterification; Haptens; Hemocyanins; Kinetics; Organophosphonates; Serum Albumin, Bovine; Thymidine	1992
ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine:D-alanine ligase (ADP) by (aminoalkyl)phosphinate and aminophosphonate analogues of D-alanine. Biochemistry, 1988, May-17, Volume: 27, Issue:10 Topics: Alanine; Binding, Competitive; Kinetics; Mathematics; Organophosphonates; Peptide Synthases; Phosphinic Acids; Protein Binding; Salmonella typhimurium; Structure-Activity Relationship	1988
Synthesis and structure-activity relationships of antibacterial phosphonopeptides incorporating (1-aminoethyl)phosphonic acid and (aminomethyl)phosphonic acid. Journal of medicinal chemistry, 1986, Volume: 29, Issue:1 Topics: Alanine; Aminoethylphosphonic Acid; Animals; Anti-Bacterial Agents; Bacteria; Biological Transport, Active; Chemical Phenomena; Chemistry; Escherichia coli; Escherichia coli Infections; Haemophilus influenzae; Mice; Organophosphonates; Organophosphorus Compounds; Peptides; Streptococcus; Structure-Activity Relationship	1986
[Transamination of 2-aminoethylphosphonic acid by Pseudomonas aeruginosa]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Jul-16, Volume: 269, Issue:2 Topics: Alanine; Amino Acids; Chromatography, Paper; Organophosphonates; Pseudomonas aeruginosa	1969
Detection of aminoalkylphosphonates with a ninhydrin-molybdate chromogenic system. Analytical biochemistry, 1971, Volume: 44, Issue:1 Topics: Alanine; Aniline Compounds; Chemical Phenomena; Chemistry; Chlorine; Colorimetry; Densitometry; Indenes; Indicators and Reagents; Ketones; Methods; Molybdenum; Organophosphonates; Phenols; Sulfites	1971
Phosphonic acid metabolism in Tetrahymena. Biochemistry, 1970, May-12, Volume: 9, Issue:10 Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Chloroform; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Ethers; Fatty Acids; Glycerides; Hydrogen-Ion Concentration; Methanol; Organophosphonates; Phospholipids; Solubility; Tetrahymena	1970
Serine transhydroxymethylase. Affinity of the active site for substrates, substrate analogues, and anions. The Journal of biological chemistry, 1971, Jun-25, Volume: 246, Issue:12 Topics: Alanine; Aldehydes; Aminoisobutyric Acids; Animals; Benzoates; Binding Sites; Chlorides; Cysteamine; Cysteine; Electrophoresis; Folic Acid; Glycine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Models, Biological; Organophosphonates; Phosphates; Potassium; Propionates; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Stereoisomerism; Sulfates; Sulfhydryl Compounds; Sulfonic Acids; Thermodynamics; Threonine; Transferases; Ultracentrifugation	1971
Cell walls of group D streptococci. II. Chemical studies on the type 1 antigen purified from the autolytic digest of cell walls. Journal of bacteriology, 1967, Volume: 94, Issue:5 Topics: Alanine; Ammonia; Antigens; Bacteriolysis; Cell Wall; Chromatography, Gas; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Glucosamine; Glucose; Glutamates; Hexosamines; Lysine; Organophosphonates; Phosphorus; Precipitin Tests; Rhamnose; Ribose; Streptococcus; Ultracentrifugation	1967
Synthesis of a GpUpU analogue containing 5'-deoxyuridine 5'-phosphonic acid and its effect upon the binding of [14C]valyl- and [14C]alanyl-tRNA to ribosomes. Biochimica et biophysica acta, 1967, Mar-29, Volume: 138, Issue:1 Topics: Alanine; Animals; Carbon Isotopes; Genetic Code; Organophosphonates; Ribosomes; RNA, Transfer; Snakes; Uracil Nucleotides; Valine; Venoms	1967
N-methyl-d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo. Brain research, 1994, Jan-28, Volume: 635, Issue:1-2 Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine; Animals; Corpus Striatum; Dopamine; Hippocampus; Homovanillic Acid; Male; Microdialysis; N-Methylaspartate; Organophosphonates; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1994
Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. British journal of pharmacology, 1996, Volume: 117, Issue:7 Topics: 2-Chloroadenosine; Alanine; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Depression, Chemical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Organophosphonates; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrazoles	1996
Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies. European journal of biochemistry, 1999, Volume: 259, Issue:1-2 Topics: Acyl Coenzyme A; Acyltransferases; Alanine; Aldehydes; Aminoethylphosphonic Acid; Biotin; Catalytic Domain; Dose-Response Relationship, Drug; Imines; Kinetics; Models, Chemical; Organophosphonates; Protein Conformation; Pyridoxal Phosphate; Stereoisomerism	1999
Phosphofurylalanine, a stable analog of phosphohistidine. Bioorganic & medicinal chemistry letters, 1999, May-17, Volume: 9, Issue:10 Topics: Alanine; Histidine; Models, Molecular; Organophosphonates; Stereoisomerism	1999
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:3 Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid	2000
Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the alpha-hydroxyl of the substrate promotes catalysis. Biochemistry, 2000, Nov-07, Volume: 39, Issue:44 Topics: Alanine; Amino Acid Sequence; Asparagine; Binding Sites; Carboxylic Acids; Catalysis; Kinetics; Mandelic Acids; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphonates; Protons; Pseudomonas putida; Racemases and Epimerases; Static Electricity; Stereoisomerism; Substrate Specificity	2000
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA. Bioorganic & medicinal chemistry letters, 2001, Apr-23, Volume: 11, Issue:8 Topics: Adenine; Alanine; Amides; Antiviral Agents; Drug Stability; Esterases; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphoric Acids; Prodrugs; Retroviridae; Structure-Activity Relationship; Tenofovir	2001
Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry, 2004, Mar-23, Volume: 43, Issue:11 Topics: Acetylcholinesterase; Alanine; Amino Acid Substitution; Animals; Butyrylcholinesterase; Cholinesterase Reactivators; Computer Simulation; Kinetics; Mice; Models, Molecular; Mutation; Organophosphonates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Structure-Activity Relationship; Tyrosine	2004
Aeromonas proteolytica aminopeptidase: an investigation of the mode of action using a quantum mechanical/molecular mechanical approach. Biochemistry, 2004, May-11, Volume: 43, Issue:18 Topics: Aeromonas; Alanine; Aminopeptidases; Animals; Bacterial Proteins; Binding Sites; Catalysis; Cations, Divalent; Cattle; Computers, Molecular; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Hydrogen Bonding; Hydrolysis; Hydroxides; Leucine; Models, Chemical; Models, Molecular; Organophosphonates; Static Electricity; Substrate Specificity; Zinc	2004
Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: 14-3-3 Proteins; Alanine; Amino Acids; Animals; Arylalkylamine N-Acetyltransferase; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Hydrocarbons; Immunohistochemistry; Kinetics; Mass Spectrometry; Melatonin; Methane; Models, Biological; Models, Chemical; Organophosphonates; Peptides; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteins; Serine; Sheep	2005
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:5 Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Area Under Curve; CD4-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Dogs; HIV-1; Humans; In Vitro Techniques; Lymphatic System; Male; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Spectrophotometry, Ultraviolet; Tenofovir; Tissue Distribution	2005
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 2005, May-31, Volume: 102, Issue:22 Topics: Adenosine Monophosphate; Alanine; Analysis of Variance; Animals; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Fructose-Bisphosphatase; Gluconeogenesis; Humans; Liver; Male; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Rats, Zucker; Spectrophotometry; Thiazoles	2005
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes, 2006, Volume: 55, Issue:6 Topics: Alanine; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Hyperglycemia; Insulin; Ketone Bodies; Lactic Acid; Male; Molecular Structure; Organophosphonates; Organophosphorus Compounds; Pancreas; Rats; Rats, Zucker; Triglycerides	2006
Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. Journal of acquired immune deficiency syndromes (1999), 2006, Volume: 43, Issue:1 Topics: Adenine; Administration, Oral; Administration, Topical; Alanine; Animals; Anti-HIV Agents; Genetic Predisposition to Disease; Macaca mulatta; Organophosphonates; Prodrugs; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Virulence	2006
Increasing permeability of phospholipid bilayer membranes to alanine with synthetic alpha-aminophosphonate carriers. Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7 Topics: Alanine; Biological Transport; Cell Membrane Permeability; Delayed-Action Preparations; Drug Carriers; Lipid Bilayers; Organophosphonates; Phospholipids	2008
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases. Molecular pharmacology, 2008, Volume: 74, Issue:1 Topics: Adenine; Alanine; Anti-HIV Agents; beta-N-Acetylhexosaminidases; Biomarkers; Cathepsin A; Cells, Cultured; Enzyme Activation; Humans; Hydrolysis; Kinetics; Leukocytes, Mononuclear; Lysosomes; Molecular Structure; Organophosphonates; Peptide Hydrolases; Prodrugs; Reverse Transcriptase Inhibitors; Serine Endopeptidases; Subcellular Fractions; Substrate Specificity; Tenofovir	2008
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharmaceutical research, 2009, Volume: 26, Issue:4 Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors	2009
CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats. European journal of pharmacology, 2008, Dec-28, Volume: 601, Issue:1-3 Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Fructose-Bisphosphatase; Fructosediphosphates; Fructosephosphates; Gluconeogenesis; Hyperglycemia; Liver; Male; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Wistar	2008
Protein phosphorylation by semisynthesis: from paper to practice. Methods in enzymology, 2009, Volume: 462 Topics: Alanine; Animals; Humans; Inteins; Organophosphonates; Phenylalanine; Phosphoamino Acids; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Recombinant Fusion Proteins	2009
Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats. European journal of pharmacology, 2009, Nov-25, Volume: 623, Issue:1-3 Topics: Alanine; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Hepatocytes; Hypoglycemic Agents; Inhibitory Concentration 50; Insulin; Lactic Acid; Male; Metformin; Organophosphonates; Organophosphorus Compounds; Radioisotope Dilution Technique; Rats; Rats, Mutant Strains; Rats, Wistar	2009
Reactions of Cre with methylphosphonate DNA: similarities and contrasts with Flp and vaccinia topoisomerase. PloS one, 2009, Sep-30, Volume: 4, Issue:9 Topics: Alanine; Arginine; Catalytic Domain; DNA; DNA Nucleotidyltransferases; DNA Topoisomerases; Escherichia coli; Genetic Variation; Hydrolysis; Integrases; Models, Biological; Organophosphonates; Static Electricity; Tyrosine; Vaccinia virus	2009
A prodrug approach towards the development of tricyclic-based FBPase inhibitors. Bioorganic & medicinal chemistry letters, 2010, May-01, Volume: 20, Issue:9 Topics: Alanine; Animals; Cells, Cultured; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Design; Enzyme Inhibitors; Haplorhini; Molecular Conformation; Organophosphonates; Prodrugs; Pyridines; Structure-Activity Relationship; Thiazoles	2010
Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology, 2010, Volume: 151, Issue:10 Topics: Alanine; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Gene Knockdown Techniques; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; RNA, Small Interfering; Thiazoles; Transfection; Up-Regulation	2010
3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase. Organic & biomolecular chemistry, 2011, Jan-07, Volume: 9, Issue:1 Topics: Alanine; Biomimetic Materials; DNA; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Structure; Organophosphonates; Phosphoric Acids	2011
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 Topics: Administration, Oral; Alanine; Amides; Animals; Biological Availability; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Male; Mice; Organophosphonates; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles	2011
Contributions of hepatic gluconeogenesis suppression and compensative glycogenolysis on the glucose-lowering effect of CS-917, a fructose 1,6-bisphosphatase inhibitor, in non-obese type 2 diabetes Goto-Kakizaki rats. Journal of pharmacological sciences, 2011, Volume: 115, Issue:3 Topics: Alanine; Amides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Fasting; Gluconeogenesis; Glucose; Glycogenolysis; Hypoglycemic Agents; Indoles; Lactic Acid; Male; Organophosphonates; Organophosphorus Compounds; Peptide Hydrolases; Rats	2011
Population pharmacokinetic model for a novel oral hypoglycemic formed in vivo: comparing the use of active metabolite data alone versus using data of upstream and downstream metabolites. Journal of clinical pharmacology, 2012, Volume: 52, Issue:3 Topics: Aged; Alanine; Computer Simulation; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Models, Biological; Molecular Structure; Organophosphonates; Prodrugs; Thiazoles	2012
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir. Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13 Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Molecular Structure; Organophosphonates; Peptides; Prodrugs; Rats; Serine; Valine	2011
Stable triazolylphosphonate analogues of phosphohistidine. Amino acids, 2012, Volume: 43, Issue:2 Topics: Alanine; Amino Acids; Catalysis; Chromatography, High Pressure Liquid; Click Chemistry; Copper; Fluorenes; Haptens; Histidine; Organophosphonates; Stereoisomerism; Triazoles	2012
Tenofovir alafenamide for HIV infection: is less more? Lancet (London, England), 2015, Jun-27, Volume: 385, Issue:9987 Topics: Adenine; Alanine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Quinolones; Tenofovir; Thiazoles	2015
First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome. AIDS (London, England), 2016, 06-01, Volume: 30, Issue:9 Topics: Absorptiometry, Photon; Adenine; Alanine; Coinfection; Dose-Response Relationship, Drug; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome	2016
Validation and implementation of liquid chromatographic-mass spectrometric (LC-MS) methods for the quantification of tenofovir prodrugs. Journal of pharmaceutical and biomedical analysis, 2018, Apr-15, Volume: 152 Topics: Adenine; Alanine; Anti-HIV Agents; Chromatography, Liquid; Humans; Organophosphonates; Prodrugs; Tandem Mass Spectrometry; Tenofovir	2018
Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2019, Volume: 138 Topics: Adenine; Administration, Rectal; Alanine; Animals; Anti-HIV Agents; Anti-Infective Agents; Enema; HIV Infections; HIV-1; Homosexuality, Male; Male; Mice; Organophosphates; Organophosphonates; Pre-Exposure Prophylaxis; Prodrugs; Rectum; Sexual and Gender Minorities; Tenofovir	2019
fabH deletion increases DHA production in Escherichia coli expressing Pfa genes. Microbial cell factories, 2018, Jun-08, Volume: 17, Issue:1 Topics: Alanine; Amino Acids; Boronic Acids; Cerulenin; Docosahexaenoic Acids; Escherichia coli; Fatty Acids; Gene Expression; Organophosphonates	2018
[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2019, Volume: 116, Issue:4 Topics: Adenine; Alanine; Alkaline Phosphatase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Fanconi Syndrome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Tenofovir; Tomography, X-Ray Computed; Treatment Outcome	2019
Hypophosphatemic Osteomalacia Due to Adefovir-Induced Fanconi Syndrome. The American journal of medicine, 2020, Volume: 133, Issue:12 Topics: Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Female; Hepatitis C, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia; Tenofovir	2020
Genome Mining Reveals the Phosphonoalamide Natural Products and a New Route in Phosphonic Acid Biosynthesis. ACS chemical biology, 2020, 07-17, Volume: 15, Issue:7 Topics: Alanine; Anti-Bacterial Agents; Bacteria; Genome, Bacterial; Genomics; Microbial Sensitivity Tests; Multigene Family; Organophosphonates; Peptides; Pyruvates	2020
Similar risk of kidney function decline between tenofovir alafenamide and besifovir dipivoxil maleate in chronic hepatitis B. Liver international : official journal of the International Association for the Study of the Liver, 2022, Volume: 42, Issue:11 Topics: Adenine; Alanine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Kidney; Longitudinal Studies; Maleates; Organophosphonates; Renal Insufficiency, Chronic; Retrospective Studies; Tenofovir; Treatment Outcome	2022