alanine has been researched along with methotrexate in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Kensler, CJ; Swiniarski, J; Venditti, JM; Wodinsky, I | 1 |
| Gerron, GG; Howard, CH; Rudman, D; Vogler, WR | 1 |
| Powis, G | 1 |
| Andrews, J; Arnold, JR; Basran, J; Birdsall, B; Feeney, J; Roberts, GC; Thomas, JA | 1 |
| Carrera, CJ; Carson, DA; Hori, H; Hori, Y; Nobori, T; Rosenbach, MD; Tran, P | 1 |
| Fitzpatrick, LR; Le, T; Sakurai, K | 1 |
| Flintoff, WF; Sadlish, H; Williams, FM | 1 |
| Cole, SP; Conseil, G; Deeley, RG; Koike, K; Leslie, EM | 1 |
| Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z | 1 |
| El-Sheikh, AA; Koenderink, JB; Krieger, E; Russel, FG; van den Heuvel, JJ | 1 |
| Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J | 1 |
| Kwon, I; Zheng, S | 1 |
| Huang, BH; Kar, S; Lee, CR; Tai, Y; Wu, KW | 1 |
| Abdel-Wahab, BA; Ali, FEM; Alkahtani, SA; Alshabi, AM; Hassanein, EHM; Mahnashi, MH | 1 |
| Bierwirth, C; Dickmanns, A; Dobbelstein, M; Freund, J; Gerber, S; Görlich, D; Groß, U; Klemke, L; Lugert, R; Manzini, V; Meister, TL; Nikolova, V; Pfaender, S; Salinas, G; Schlösser, D; Sitte, M; Stegmann, KM; Wollnik, B | 1 |
| Alakuş, H; Cellat, M; Etyemez, M; Güvenç, M; İşler, CT; Kutlu, T; Kuzu, M | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
1 review(s) available for alanine and methotrexate
| Article | Year |
|---|---|
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine | 1983 |
16 other study(ies) available for alanine and methotrexate
| Article | Year |
|---|---|
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Mice; Neoplasm Transplantation; Prednisone; Procarbazine; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Transplantation, Homologous; Vinblastine; Vincristine | 1974 |
Observations on the plasma amino acids of patients with acute leukemia.
Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine | 1971 |
Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.
Topics: Alanine; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Mutagenesis, Site-Directed; NADP; Solutions; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Threonine | 1994 |
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Vectors; Humans; Lung Neoplasms; Methionine; Methotrexate; Neoplasm Proteins; Purine-Nucleoside Phosphorylase; Purines; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cricetinae; Gastric Mucosa; Indomethacin; Male; Mesocricetus; Methotrexate; Mice; Neutrophils; Peroxidase; Pyloric Antrum; Quinolones | 1999 |
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins | 2003 |
Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Anions; Biological Transport; Blotting, Northern; Cell Line; Cell Membrane; Cytoplasm; Dose-Response Relationship, Drug; Genetic Vectors; Humans; Kidney; Kinetics; Methotrexate; Microscopy, Confocal; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Nucleotides; Proline; Protein Binding; Protein Transport; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity; Transfection; Vanadates | 2004 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosine; DNA Probes; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Humans; Leucovorin; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Polymorphism, Genetic; Random Allocation; Thymidylate Synthase; Thymine; Transfection; Transplantation, Heterologous; Valine | 2004 |
Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4).
Topics: Alanine; Amino Acid Substitution; Arginine; Baculoviridae; Binding Sites; Biological Transport; Cell Line; Cell Membrane; Cellular Structures; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Guanosine Monophosphate; Humans; Kidney; Kinetics; Methotrexate; Models, Molecular; Multidrug Resistance-Associated Proteins; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary | 2008 |
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides | 1981 |
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan | 2013 |
A simple N,N'-dicyclohexylurea adduct of β-alanine can self-assemble to generate nano-morphological versatility in response to different environmental conditions.
Topics: Alanine; Drug Carriers; Methotrexate; Nanostructures; Urea | 2014 |
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Janus Kinase 1; Liver; Male; Methotrexate; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Quinolones; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Transcription Factor RelA | 2020 |
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Culture Techniques; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Folic Acid Antagonists; Humans; Methotrexate; RNA, Viral; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
Topics: Alanine; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Aspartate Aminotransferases; C-Reactive Protein; Catalase; Creatinine; Cyclohexenes; Cyclooxygenase 2; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Interleukin-6; Malondialdehyde; Methotrexate; NF-kappa B; Rats; Terpenes; Tumor Necrosis Factor-alpha; Urea | 2022 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |