alanine and methotrexate

alanine has been researched along with methotrexate in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19904 (23.53)18.7374
1990's3 (17.65)18.2507
2000's5 (29.41)29.6817
2010's2 (11.76)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Kensler, CJ; Swiniarski, J; Venditti, JM; Wodinsky, I1
Gerron, GG; Howard, CH; Rudman, D; Vogler, WR1
Powis, G1
Andrews, J; Arnold, JR; Basran, J; Birdsall, B; Feeney, J; Roberts, GC; Thomas, JA1
Carrera, CJ; Carson, DA; Hori, H; Hori, Y; Nobori, T; Rosenbach, MD; Tran, P1
Fitzpatrick, LR; Le, T; Sakurai, K1
Flintoff, WF; Sadlish, H; Williams, FM1
Cole, SP; Conseil, G; Deeley, RG; Koike, K; Leslie, EM1
Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z1
El-Sheikh, AA; Koenderink, JB; Krieger, E; Russel, FG; van den Heuvel, JJ1
Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J1
Kwon, I; Zheng, S1
Huang, BH; Kar, S; Lee, CR; Tai, Y; Wu, KW1
Abdel-Wahab, BA; Ali, FEM; Alkahtani, SA; Alshabi, AM; Hassanein, EHM; Mahnashi, MH1
Bierwirth, C; Dickmanns, A; Dobbelstein, M; Freund, J; Gerber, S; Görlich, D; Groß, U; Klemke, L; Lugert, R; Manzini, V; Meister, TL; Nikolova, V; Pfaender, S; Salinas, G; Schlösser, D; Sitte, M; Stegmann, KM; Wollnik, B1
Alakuş, H; Cellat, M; Etyemez, M; Güvenç, M; İşler, CT; Kutlu, T; Kuzu, M1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1

Reviews

1 review(s) available for alanine and methotrexate

ArticleYear
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
    Drug metabolism reviews, 1983, Volume: 14, Issue:6

    Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine

1983

Other Studies

16 other study(ies) available for alanine and methotrexate

ArticleYear
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
    Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1

    Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Mice; Neoplasm Transplantation; Prednisone; Procarbazine; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Transplantation, Homologous; Vinblastine; Vincristine

1974
Observations on the plasma amino acids of patients with acute leukemia.
    Cancer research, 1971, Volume: 31, Issue:8

    Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine

1971
Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.
    Protein engineering, 1994, Volume: 7, Issue:6

    Topics: Alanine; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Mutagenesis, Site-Directed; NADP; Solutions; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Threonine

1994
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
    Cancer research, 1996, Dec-15, Volume: 56, Issue:24

    Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Vectors; Humans; Lung Neoplasms; Methionine; Methotrexate; Neoplasm Proteins; Purine-Nucleoside Phosphorylase; Purines; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1996
Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?
    Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:2

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cricetinae; Gastric Mucosa; Indomethacin; Male; Mesocricetus; Methotrexate; Mice; Neutrophils; Peroxidase; Pyloric Antrum; Quinolones

1999
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
    The Journal of biological chemistry, 2003, Oct-17, Volume: 278, Issue:42

    Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins

2003
Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Anions; Biological Transport; Blotting, Northern; Cell Line; Cell Membrane; Cytoplasm; Dose-Response Relationship, Drug; Genetic Vectors; Humans; Kidney; Kinetics; Methotrexate; Microscopy, Confocal; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Nucleotides; Proline; Protein Binding; Protein Transport; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity; Transfection; Vanadates

2004
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
    Journal of the National Cancer Institute, 2004, Jan-21, Volume: 96, Issue:2

    Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosine; DNA Probes; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Humans; Leucovorin; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Polymorphism, Genetic; Random Allocation; Thymidylate Synthase; Thymine; Transfection; Transplantation, Heterologous; Valine

2004
Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4).
    Molecular pharmacology, 2008, Volume: 74, Issue:4

    Topics: Alanine; Amino Acid Substitution; Arginine; Baculoviridae; Binding Sites; Biological Transport; Cell Line; Cell Membrane; Cellular Structures; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Guanosine Monophosphate; Humans; Kidney; Kinetics; Methotrexate; Models, Molecular; Multidrug Resistance-Associated Proteins; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary

2008
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
    Biochemical pharmacology, 1981, Sep-01, Volume: 30, Issue:17

    Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides

1981
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
    Biotechnology and bioengineering, 2013, Volume: 110, Issue:9

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan

2013
A simple N,N'-dicyclohexylurea adduct of β-alanine can self-assemble to generate nano-morphological versatility in response to different environmental conditions.
    Soft matter, 2014, Oct-28, Volume: 10, Issue:40

    Topics: Alanine; Drug Carriers; Methotrexate; Nanostructures; Urea

2014
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
    Immunopharmacology and immunotoxicology, 2020, Volume: 42, Issue:5

    Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Janus Kinase 1; Liver; Male; Methotrexate; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Quinolones; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Transcription Factor RelA

2020
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
    Virus research, 2021, Volume: 302

    Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Culture Techniques; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Folic Acid Antagonists; Humans; Methotrexate; RNA, Viral; SARS-CoV-2; Vero Cells; Virus Replication

2021
Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:9

    Topics: Alanine; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Aspartate Aminotransferases; C-Reactive Protein; Catalase; Creatinine; Cyclohexenes; Cyclooxygenase 2; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Interleukin-6; Malondialdehyde; Methotrexate; NF-kappa B; Rats; Terpenes; Tumor Necrosis Factor-alpha; Urea

2022
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009