alanine and lanthionine

alanine has been researched along with lanthionine in 187 studies

Research

Studies (187)

TimeframeStudies, this research(%)All Research%
pre-199026 (13.90)18.7374
1990's25 (13.37)18.2507
2000's46 (24.60)29.6817
2010's74 (39.57)24.3611
2020's16 (8.56)2.80

Authors

AuthorsStudies
Klostermeyer, H; Watanabe, K1
Endresen, C; Hofstad, T; Jensen, HB; Vasstrand, EN1
Feeney, RE; Nashef, AS; Walsh, RG1
De Bree, PK; Kamerling, JP; Wadman, SK1
Fiedler, HP; Hörner, T; Jung, G; Kellner, R; Ungermann, V; Utz, R; Zähner, H1
Fredenhagen, A; Hänni, E; Märki, F; van Oostrum, J1
Chang, JY; Knecht, R1
Fredriksen, A; Jensen, HB; Vasstrand, EN1
Fujita, H; Fukase, K; Goodman, M; Kitazawa, M; Mierke, DF; Palmer, DE; Pattaroni, C; Shiba, T; Wakamiya, T1
Cavallini, D; Costa, M; Fontana, M; Pecci, I; Pensa, B1
Entian, KD; Götz, F; Hörner, T; Jung, G; Kellner, R; Schnell, N; Zähner, H1
Bessems, GJ; Hoenders, HJ; Rennen, HJ1
Cavallini, D; Federici, G; Nardini, M; Ricci, G1
Kunert, J1
Brandis, H; Cramer, WA; Grossgarten, M; Sahl, HG; Widger, WR1
Baker, DH; Finley, JW; Robbins, KR1
Hofstad, T; Jensen, HB; Miron, T; Vasstrand, EN1
Achilli, M; Cavallini, D; Federici, G; Lucente, G; Ricci, G1
Jack, RW; Sahl, HG1
Jung, G; Metzger, JW; Zimmermann, N1
Blanot, D; Mengin-Lecreulx, D; van Heijenoort, J1
Carne, A; Jack, RW; Jung, G; Metzger, J; Sahl, HG; Stefanović, S; Tagg, J1
Cohen, GN; Johnson, EJ; Marlière, P; Mengin-Lecreulx, D; Pochet, S; Richaud, C1
Benz, R; Jack, R; Sahl, HG; Tagg, J1
Ronson, CW; Ross, KF; Tagg, JR1
Bierbaum, G; Sahl, HG1
Mollet, B; Pittet, AC; Pridmore, D; Rekhif, N; Suri, B1
Gasson, MJ1
Bierbaum, G; Heidrich, C; Jack, R; Sahl, HG1
Nes, IF; Tagg, JR1
Israil, AM; Jack, RW; Jung, G; Sahl, HG1
Bierbaum, G; Brötz, H; Jack, R; Kluczny, C; Molitor, E; Sahl, HG1
Coy, DH; Goodman, M; Kim, HS; Liapakis, G; Mattern, RH; Medzihradszky, KF; Melacini, G; Osapay, G; Prokai, L; Reisine, T; Wang, SH; Zhu, Q1
Goodman, M; Melacini, G; Osapay, G; Zhu, Q1
Ageta, T; Duprè, S; Fontana, M; Kodama, H; Sugahara, K; Yu, S; Zhang, J1
Casadesús, J; D'Ari, R1
Groeger, S; Jarosinski, MA; Liu, CF; Mayer, JP; Zhang, J1
Friedman, M1
Kärcher, J; Lubini, P; Pohl, E; Schneider, TR; Sheldrick, GM1
Allen, C; Bradley, M; Burrage, S; Cardno, M; Essex, JW; Raynham, T; Swali, V; Williams, G1
Goodman, M; Jiang, X; Li, H1
Hill, C; McAuliffe, O; Ross, RP1
Goodman, M; Rew, Y; Zapf, C1
Cassel, JA; Chung, NN; DeHaven, RN; Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, C; Taulane, JP; Yaksh, TL1
Helin, J; Koponen, O; Qiao, M; Saris, PEJ; Tolonen, M; Wahlström, G1
Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, CI; Taulane, JP; Yaksh, TL1
Goodman, M; Smith, ND1
SCHOBERL, A; WAGNER, A1
MORGAN, JF; MORTON, HJ1
MIJAL, CF; SULLIVAN, MX1
EARLAND, C; RAVEN, DJ1
GOLSCH, E; ZAHN, H1
CREWTHER, WG; DOWLING, LM1
PRESCOTT, JM1
Bregant, S; Bulic-Subanovic, N; Chubb, NA; Driscoll, PC; Elliott, SL; Gaffney, PR; Groussier, MF; Harris, R; Mohd Mustapa, MF; Mould, J; Schultz, D; Tabor, AB1
Chubb, NA; Driscoll, PC; Esposito, D; Harris, R; Mohd Mustapa, MF; Mould, J; Schultz, D; Tabor, AB1
Averin, O; Gieselman, MD; van der Donk, WA; Zhou, H; Zhu, Y1
IRION, W1
FOLK, JE; SULLIVAN, MX1
Carpenter, MR; Cotter, PD; Hill, C; Martin, NI; Ross, RP; Sprules, T; Vederas, JC1
Hill, JM; Hu, F; LeGrand, RD; Linetsky, M1
Cotter, PD; Hill, C; Ross, RP1
Consaul, SA; Crick, DC; Mahapatra, S; Pavelka, MS; Wright, LF1
Bregant, S; Tabor, AB1
de Boef, E; Driessen, AJ; Kuipers, A; Kuipers, OP; Leenhouts, KJ; Moll, GN; Rink, R1
LeGrand, RD; Linetsky, M1
Aso, Y; Harada, Y; Nagao, J; Nakayama, J; Shioya, K; Sonomoto, K; Zendo, T1
Durrant, MC; Kodani, S; Lodato, MA; Picart, F; Willey, JM1
Kodani, S; Nodwell, JR; Willems, A; Willey, JM1
Brock, R; Jung, G; Seyberth, T; Voss, S; Wiesmüller, KH1
Baker, DH1
Breukink, E1
Avenoza, A; Busto, JH; Jiménez-Osés, G; Peregrina, JM1
Fujimoto, Y; Fukase, K; Kawasaki, A; Kusumoto, S; Takada, H; Uehara, A1
Chatterjee, C; Cooper, L; Patton, GC; Paul, M; van der Donk, WA1
Ghalit, N; Hilbers, HW; Kemmink, J; Liskamp, RM; Rijkers, DT; Versluis, C1
He, H; Lipowska, M; Marzilli, LG; Taylor, AT; Xu, X1
Cobb, SL; Vederas, JC1
Höcker, H; Popescu, C1
Liu, H; Pattabiraman, VR; Vederas, JC1
Aso, H; Fujimoto, Y; Fukase, K; Kawasaki, A; Kitazawa, H; Saito, T; Shimazu, T; Takada, H; Tohno, M; Uehara, A1
Bonev, B; Breukink, E; Carey, S; Chan, WC; Narbad, A; Parisot, J1
Chatterjee, C; Cooper, LE; Patton, GC; Paul, M; van der Donk, WA1
Fukao, M; Kohda, D; Nakayama, J; Obita, T; Sonomoto, K; Yoneyama, F; Zendo, T1
CALDWELL, A; HORN, MJ; JONES, DB2
Martin, NI1
Håkansson, K; Kalli, A; Kastrantas, J; Orugunty, RS; Smith, L; Wilson-Stanford, S1
Haugen, HS; Kristiansen, PE; Nissen-Meyer, J; Oppegård, C; Rogne, P1
Balaram, P; Thakur, SS1
Basler, DA; Cagney, JW; Carroll, JA; Chen, ZY; Egodage, K; Lipartito, C; Poruthoor, S; Schlittler, MR; Storrs, SB; Tou, JS; Violand, BN1
Banerjee, R; Chiku, T; Padovani, D; Singh, S; Vitvitsky, V; Zhu, W1
Cooper, LE; Li, B; van der Donk, WA1
Banerjee, R; Chiku, T; Leslie, RA; Padovani, D; Singh, S1
Khusainov, R; Kuipers, OP; Lubelski, J1
Kuipers, A; Moll, GN; Rink, R1
Draelos, ZD1
MIDDLEBROOK, WR; PHILLIPS, H1
Bibb, MJ; Claesen, J; Goto, Y; Li, B; Shi, Y; van der Donk, WA1
Ito, S; Kamo, M; Kato, H; Kezuka, Y; Kunimatsu, K; Tamura, H; Yoshida, Y1
Christov, A; Hensley, K; Venkova, K1
Brijs, K; De Vleeschouwer, K; Delcour, JA; Hendrickx, ME; Lagrain, B; Rombouts, I1
Cotter, PD; Hill, C; O'Connor, PM; Ross, RP; Suda, S; Westerbeek, A1
Callery, PS; Cooper, AJ; Pinto, JT1
Ajandouz, EH; Crost, EH; Fons, M; Geraert, PA; Puigserver, A; Villard, C1
Inoue, T; Ito, A; Kitajima, Y; Shimizu, N; Shinohara, K; Takehara, K1
Appleyard, AN; Mothia, B; Tabor, AB; Wadman, S1
Brijs, K; Delcour, JA; Lagrain, B; Rombouts, I1
Tabor, AB1
Avenoza, A; Aydillo, C; Busto, JH; Jiménez-Osés, G; Peregrina, JM; Zurbano, MM1
Krawczyk, B; Krawczyk, JM; Nachtigall, J; Pesic, A; Süssmuth, RD; Völler, GH1
Tang, W; van der Donk, WA2
van der Donk, WA; Wang, H1
Ensle, P; Krawczyk, B; Süssmuth, RD; Völler, GH; Völler, J1
Khawli, LA; Pastuskovas, CV; Stults, JT; Yin, S1
Hirschberger, LL; Kožich, V; Krijt, J; Roman, HB; Stipanuk, MH; Valli, A1
Castro Faria Neto, HC; Floyd, RA; Hensley, K; Towner, RA; Zimmerman, GA1
van der Donk, WA; Yu, Y; Zhang, Q1
Donadio, S; Gaspari, E; Iorio, M; Maffioli, SI; Monciardini, P; Sosio, M1
Sareen, D; Singh, M1
Sakamaki, R; Shimada, Y; Takahashi, N; Washio, J; Yamada, M1
Mukherjee, S; van der Donk, WA1
Blanot, D; Denoël, T; Gerards, T; Joris, B; Lemaire, C; Luxen, A; Zervosen, A1
Banerjee, R; Chi, YY; DeRatt, BN; Gregory, JF; Kabil, O; Ralat, MA1
Breukink, E; Liskamp, RM; Peters, N; Quarles van Ufford, HL; Rijkers, DT; Slootweg, JC1
Li, JL; Lohans, CT; Vederas, JC1
van der Donk, WA; Wang, H; Yang, X; Zhang, Q1
Chen, J; van der Donk, WA; Zeng, M1
Blanot, D; Denoël, T; Hervé, M; Joris, B; Lemaire, C; Luxen, A; Zaragoza, G; Zervosen, A1
Ha, T; Thibodeaux, CJ; van der Donk, WA1
Denton, TT; Hensley, K1
Altschuh, D; Chekkat, N; Estieu-Gionnet, K; Fournel, S; Gronemeyer, H; Guichard, G; Lechner, MC; Odaert, B; Pavet, V; Pulka-Ziach, K; Rohac, R; Smulski, CR; Zeder-Lutz, G1
Jones, B; Kazlauskas, RJ1
Houk, KN; Jiménez-Osés, G; Tang, W; van der Donk, WA1
Ananias, HJ; Carlucci, G; de Jong, IJ; de Paula Faria, D; Dierckx, RA; Elsinga, PH; Helfrich, W; Kuipers, A; Moll, GN; Rink, R1
Ding, W; Li, Y; Zhang, Q1
Doroghazi, JR; van der Donk, WA; Walker, MC; Zhang, Q; Zhao, X1
Nagao, J; Nakayama, J; Nishie, M; Noguchi, M; Shimafuji, C; Shioya, K; Sonomoto, K; Zendo, T1
Iftime, D; Imhoff, JF; Jasyk, M; Kulik, A; Stegmann, E; Süssmuth, RD; Weber, T; Wohlleben, W1
Brunati, C; Cruz, JC; Donadio, S; Gaspari, E; Iorio, M; Maffioli, SI; Monciardini, P; Simone, M; Sosio, M; Wellington, E1
Carpentier, SC; Delcour, JA; Lambrecht, MA; Rombouts, I1
Ješina, P; Kožich, V; Kraus, JP; Krijt, J; Majtán, T; Melenovská, P; Sokolová, J; Vozdek, R1
Huo, L; van der Donk, WA1
Amoresano, A; Cirillo, G; Di Nunzio, A; Fontanarosa, C; Ingrosso, D; Pane, F; Perna, AF; Pucci, P; Trepiccione, F; Vigorito, C; Zacchia, M1
Chen, T; Garg, N; Goto, Y; van der Donk, WA1
Tang, W; Thibodeaux, GN; van der Donk, WA1
Atkins, WM; Bouldin, SD; Guttman, M; Outten, CE; Scian, M1
Ingrosso, D; Perna, AF; Trepiccione, F; Zacchia, M1
Chen, J; Dutta, D; He, C; Koh, TH; van der Donk, WA; Zeng, M1
Cai, YD; Chen, L; Huang, T; Wang, S; Zhang, N; Zhang, YH1
Becker, JW; Berta-Thompson, JW; Chisholm, SW; Cubillos-Ruiz, A; van der Donk, WA1
Lagedroste, M; Schmitt, L; Smits, SHJ1
Gregory, JF; Kent, J; Kožich, V; Kraus, JP; Krijt, J; Křížková, M; Majtan, T; Ralat, MA; Sokolová, J1
Bhaumik, S; Biswal, HS; Dolle, AB; Gowd, KH; Jagadeesh, N; Prakash, S1
Anishchenko, E; D'Aniello, S; Ingrosso, D; Perna, AF; Trepiccione, F; Vigorito, C; Zacchia, M1
Denoël, T; Lemaire, C; Luxen, A1
Bobeica, SC; van der Donk, WA1
Greco, I; Lametsch, R; Mitra, B; Ruiz-Carrascal, J1
De Luca, S; Digilio, G; Jiménez-Osés, G; Menchise, V; Peregrina, JM; Saviano, M; Tovillas, P; Verdoliva, V1
Franklin, R; Kuipers, A; Moll, GN; Wagner, E1
Deng, J; Held, M; Kuipers, OP; Montalbán-López, M; Panke, S; Peterhoff, D; Schmitt, S; Wagner, R1
Bobeica, SC; Bothwell, IR; Hegemann, JD; van der Donk, WA; Walker, MC1
Anishchenko, E; Capasso, R; Capolongo, G; Ingrosso, D; Lombari, P; Mele, L; Perna, AF; Trepiccione, F; Vigorito, C; Zacchia, M1
Abbate, M; Benigni, A; Cassis, P; Cerullo, D; Corna, D; Locatelli, M; Remuzzi, G; Rottoli, D; Villa, S; Zoja, C1
Mothersole, RG; Wolthers, KR1
Acedo, JZ; An, L; Bothwell, IR; Frazier, C; Trouth, A; van der Donk, WA1
De Luca, S; Digilio, G; Jiménez-Osés, G; Peregrina, JM; Tovillas, P; Verdoliva, V1
Baindara, P; Korpole, S; Nayudu, N1
Alessandri, C; Brandstetter, H; Gadermaier, G; Griessner, I; Huber, CG; Mari, A; Regl, C; Soh, WT; Stemeseder, T; Stock, LG; Stutz, H; Völker, T; Wildner, S1
Chaudhary, S; Sareen, D; Singh, M1
Handfield, M; Hillman, JD; Kirichenko, K; Park, JH1
Bosma, T; Cebrián, R; Fu, Y; Kuipers, OP; Moll, GN; Rink, R; Zhao, X1
Gornbein, JA; Koos, BJ1
Halbert, ME; Kittrell, CG; Limbrick, EM; Scott, DH; Shah, SC1
Bosma, T; de Vries, L; Kuipers, A; Moll, GN; Namsolleck, P; Rink, R1
Mescheder, A; Moll, GN; Namsolleck, P; Richardson, A1
Chen, J; Chooi, KP; Davis, BG; Galan, SRG; Garg, N; He, C; Hutchings, GJ; Jones, LH; Lai, KY; Liu, S; Mohammed, S; Nair, SK; Raj, R; Riedl, J; van der Donk, WA; Zeng, M; Zeng, Y; Zhou, TH1
Aziz, S; Berscheid, A; Brötz-Oesterhelt, H; Gehringer, M; Gross, H; Kramer, M; Saad, H; Straetener, J1
Arias-Orozco, P; Cebrián, R; Inklaar, M; Kuipers, OP; Lanooij, J1
De Luca, S; Digilio, G; Saviano, M; Verdoliva, V1
Fernandez-Lima, FA; Jeanne Dit Fouque, K; Jiménez-Osés, G; Le, T; Navo, CD; Santos-Fernandez, M; Sarksian, R; van der Donk, WA1
Genilloud, O; Liang, H; Lopez, IJ; Sánchez-Hidalgo, M; van der Donk, WA1
Kuipers, OP; Viel, JH1
Nair, SK; Pei, ZF; Sarksian, R; van der Donk, WA; Zhu, L1
Brinker, CJ; Denton, TT; Gonzalez Porras, MA; Gransee, HM; Mantilla, CB; Noureddine, A; Shen, D; Sieck, GC; Webb, KL1

Reviews

23 review(s) available for alanine and lanthionine

ArticleYear
Unique peptide modifications involved in the biosynthesis of lantibiotics.
    Trends in biotechnology, 1995, Volume: 13, Issue:7

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Forecasting; Gene Expression Regulation, Bacterial; Genes, Bacterial; Models, Chemical; Molecular Sequence Data; Peptides; Protein Precursors; Protein Processing, Post-Translational; Sulfides

1995
Lantibiotics--unusually modified bacteriocin-like peptides from gram-positive bacteria.
    Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1993, Volume: 278, Issue:1

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Gram-Positive Bacteria; Molecular Sequence Data; Peptides; Sulfides

1993
Lantibiotics.
    Biotechnology (Reading, Mass.), 1995, Volume: 28

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Infections; Genes, Bacterial; Gram-Positive Bacteria; Humans; Molecular Sequence Data; Peptides, Cyclic; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Structure, Secondary; Sulfides

1995
The genetics of lantibiotic biosynthesis.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1995, Volume: 17, Issue:9

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Biological Transport; Chromosome Mapping; Chromosomes, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Gram-Positive Bacteria; Molecular Sequence Data; Multigene Family; Operon; Peptides, Cyclic; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals; Sulfides

1995
Novel lantibiotics and their pre-peptides.
    Antonie van Leeuwenhoek, 1996, Volume: 69, Issue:2

    Topics: Alanine; Anti-Bacterial Agents; Bacteriocins; Gram-Positive Bacteria; Protein Sorting Signals; Sulfides

1996
Chemistry, biochemistry, nutrition, and microbiology of lysinoalanine, lanthionine, and histidinoalanine in food and other proteins.
    Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:4

    Topics: Alanine; Animal Nutritional Physiological Phenomena; Animals; Dietary Proteins; Digestion; Dipeptides; Food Analysis; Humans; Lysinoalanine; Mice; Nutritional Physiological Phenomena; Proteins; Rats; Sulfides

1999
Lantibiotics: structure, biosynthesis and mode of action.
    FEMS microbiology reviews, 2001, Volume: 25, Issue:3

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Molecular Sequence Data; Peptides; Sulfides

2001
New reagents, reactions, and peptidomimetics for drug design.
    Biopolymers, 2001, Volume: 60, Issue:3

    Topics: Alanine; Amines; Amino Acids; Drug Design; Enkephalins; Guanidine; Indicators and Reagents; Models, Chemical; Organophosphates; Peptides; Sulfides; Triazines

2001
Bacterial lantibiotics: strategies to improve therapeutic potential.
    Current protein & peptide science, 2005, Volume: 6, Issue:1

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Bacteria; Molecular Conformation; Molecular Sequence Data; Mutation; Peptides; Sequence Homology, Amino Acid; Sulfhydryl Compounds; Sulfides

2005
Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor.
    Molecular microbiology, 2006, Volume: 59, Issue:3

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Hyphae; Molecular Sequence Data; Protein Conformation; Streptomyces coelicolor; Sulfides; Surface-Active Agents

2006
A lesson in efficient killing from two-component lantibiotics.
    Molecular microbiology, 2006, Volume: 61, Issue:2

    Topics: Alanine; Anti-Bacterial Agents; Bacteriocins; Nisin; Sulfides; Uridine Diphosphate N-Acetylmuramic Acid

2006
Structure-function relationships of the non-lanthionine-containing peptide (class II) bacteriocins produced by gram-positive bacteria.
    Current pharmaceutical biotechnology, 2009, Volume: 10, Issue:1

    Topics: Alanine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Bacteriocins; Gram-Positive Bacteria; Humans; Molecular Sequence Data; Peptides; Structure-Activity Relationship; Sulfides

2009
Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides.
    Antonie van Leeuwenhoek, 2010, Volume: 97, Issue:4

    Topics: Alanine; Amino Acids; Bacteria; Biosynthetic Pathways; Genetic Engineering; Protein Biosynthesis; Sulfides

2010
Emerging biological importance of central nervous system lanthionines.
    Molecules (Basel, Switzerland), 2010, Aug-13, Volume: 15, Issue:8

    Topics: Alanine; Amination; Animals; Central Nervous System; Cystathionine beta-Synthase; Humans; Neuroprotective Agents; Substrate Specificity; Sulfides

2010
Reversible and irreversible protein glutathionylation: biological and clinical aspects.
    Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:7

    Topics: Alanine; Aldehydes; Alzheimer Disease; Apoptosis; Busulfan; Cataract; Cell Cycle; Cystic Fibrosis; Diabetes Mellitus, Type 2; Glutathione; Glutathione Disulfide; Glutathione Transferase; Neoplasms; Oxidation-Reduction; Oxidative Stress; Protein Folding; Proteins; Signal Transduction; Sulfides

2011
The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides.
    Organic & biomolecular chemistry, 2011, Oct-26, Volume: 9, Issue:22

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Biomimetics; Biotransformation; Chemistry, Pharmaceutical; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Polycyclic Compounds; Protein Engineering; Solid-Phase Synthesis Techniques; Sulfides

2011
Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.
    Free radical biology & medicine, 2013, Volume: 62

    Topics: Alanine; Antineoplastic Agents; Benzenesulfonates; Cyclic N-Oxides; Drug Combinations; Free Radicals; Humans; Imines; Neoplasms; Neurodegenerative Diseases; Sulfides

2013
Insights into the evolution of lanthipeptide biosynthesis.
    Protein science : a publication of the Protein Society, 2013, Volume: 22, Issue:11

    Topics: Alanine; Amino Acids; Bacterial Proteins; Cyclization; Cysteine; Evolution, Molecular; Hydro-Lyases; Multienzyme Complexes; Peptides, Cyclic; Protein Processing, Post-Translational; Serine; Sulfides; Threonine

2013
Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.
    Free radical biology & medicine, 2015, Volume: 78

    Topics: Alanine; Animals; Brain; Brain Diseases; Cystathionine beta-Synthase; Humans; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Sulfides; Sulfur

2015
Substrate-Controlled Stereochemistry in Natural Product Biosynthesis.
    ACS chemical biology, 2015, Jul-17, Volume: 10, Issue:7

    Topics: Acyl Carrier Protein; Alanine; Amino Acid Sequence; Animals; Biological Products; Biosynthetic Pathways; Humans; Models, Molecular; Molecular Sequence Data; Peptides; Peptides, Cyclic; Polyketides; Stereoisomerism; Substrate Specificity; Sulfides

2015
The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin.
    Toxins, 2017, 01-10, Volume: 9, Issue:1

    Topics: Alanine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Renal Dialysis; Sulfides; Uremia

2017
Progress in Lanthionine and Protected Lanthionine Synthesis.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Oct-17, Volume: 24, Issue:58

    Topics: Alanine; Chemistry Techniques, Analytical; Molecular Structure; Stereoisomerism; Sulfides

2018
Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors.
    Biochemical Society transactions, 2020, 10-30, Volume: 48, Issue:5

    Topics: Alanine; Animals; Anti-Bacterial Agents; Bacterial Proteins; Disulfides; Drug Discovery; Gram-Negative Bacteria; Gram-Positive Bacteria; GTP-Binding Proteins; Humans; Lanthanoid Series Elements; Membrane Transport Proteins; Mice; Peptide Hydrolases; Peptides; Protein Domains; Protein Processing, Post-Translational; Protein Sorting Signals; Rats; Receptors, G-Protein-Coupled; Substrate Specificity; Sulfides

2020

Trials

1 trial(s) available for alanine and lanthionine

ArticleYear
Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.
    Biochimie, 2016, Volume: 126

    Topics: Adult; Aged; Alanine; Female; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Male; Middle Aged; Renal Dialysis; Sulfides; Uremia

2016

Other Studies

163 other study(ies) available for alanine and lanthionine

ArticleYear
[Formation of dehydroalanine, lanthionine and lysinoalanine during heat treatment of beta-lactoglobuline A (author's transl)].
    Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 1977, Jun-30, Volume: 164, Issue:2

    Topics: Alanine; Amino Acids; Animals; Cattle; Chemical Phenomena; Chemistry; Dipeptides; Female; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Lactoglobulins; Lysine; Sulfides

1977
Demonstration of lanthionine as a natural constituent of the peptidoglycan of Fusobacterium nucleatum.
    Infection and immunity, 1979, Volume: 25, Issue:3

    Topics: Alanine; Amino Acids; Amino Acids, Diamino; Amino Sugars; Fusobacterium; Peptidoglycan; Sulfides

1979
Intramolecular cross-linking of proteins by formation of lysinoalanine or lanthionine. Modification of disulfides in ovomucoids.
    International journal of peptide and protein research, 1979, Volume: 14, Issue:4

    Topics: Alanine; Alkalies; Amino Acids; Animals; Chemical Phenomena; Chemistry; Cross-Linking Reagents; Egg Proteins; Electrophoresis, Disc; Hexosamines; Hexoses; Lysine; Lysinoalanine; Ovomucin; Poultry; Proteins; Sodium Cyanide; Subtilisins; Sulfhydryl Compounds; Sulfides; Thiocyanates; Trypsin Inhibitors

1979
Lanthionine detected in human urine.
    Clinica chimica acta; international journal of clinical chemistry, 1978, Jan-16, Volume: 82, Issue:3

    Topics: Alanine; Amino Acids, Sulfur; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Humans; Mass Spectrometry; Methods; Sulfides

1978
Comparative studies on the fermentative production of lantibiotics by staphylococci.
    Applied microbiology and biotechnology, 1990, Volume: 32, Issue:5

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Chromatography, Gel; Culture Media; Fermentation; Microbial Sensitivity Tests; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Peptides, Cyclic; Staphylococcus; Staphylococcus epidermidis; Sulfides

1990
Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2.
    Biochemical pharmacology, 1991, Oct-24, Volume: 42, Issue:10

    Topics: Alanine; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacteriocins; Binding, Competitive; Circular Dichroism; Humans; Neutrophils; Peptides; Peptides, Cyclic; Phospholipases A; Phospholipases A2; Phospholipids; Substrate Specificity; Sulfides

1991
Direct analysis of the disulfide content of proteins: methods for monitoring the stability and refolding process of cystine-containing proteins.
    Analytical biochemistry, 1991, Aug-15, Volume: 197, Issue:1

    Topics: Alanine; Amino Acids; Animals; Chromatography, High Pressure Liquid; Cysteine; Cystine; Diazonium Compounds; Drug Stability; Humans; Lysinoalanine; Protein Conformation; Proteins; Reproducibility of Results; Sensitivity and Specificity; Sulfanilic Acids; Sulfides

1991
Peptidoglycan precursor from Fusobacterium nucleatum contains lanthionine.
    Journal of bacteriology, 1991, Volume: 173, Issue:2

    Topics: Alanine; Carbon Radioisotopes; Chromatography, Gel; Chromatography, High Pressure Liquid; Fusobacterium; Peptidoglycan; Sulfides; Uridine Diphosphate

1991
Interactive NMR and computer simulation studies of lanthionine-ring structures.
    Biopolymers, 1989, Volume: 28, Issue:1

    Topics: Alanine; Amino Acid Sequence; Computer Simulation; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nisin; Peptides, Cyclic; Protein Conformation; Sulfides

1989
High-performance liquid chromatography of cystathionine, lanthionine and aminoethylcysteine using o-phthaldialdehyde precolumn derivatization.
    Journal of chromatography, 1989, May-30, Volume: 490, Issue:2

    Topics: Alanine; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Indicators and Reagents; o-Phthalaldehyde; Sulfides

1989
Gallidermin: a new lanthionine-containing polypeptide antibiotic.
    European journal of biochemistry, 1988, Oct-15, Volume: 177, Issue:1

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Gas Chromatography-Mass Spectrometry; Microbial Sensitivity Tests; Molecular Sequence Data; Peptides; Peptides, Cyclic; Staphylococcus; Sulfides

1988
Lanthionine, a protein cross-link in cataractous human lenses.
    Experimental eye research, 1987, Volume: 44, Issue:5

    Topics: Alanine; Amino Acids; Cataract; Crystallins; Cystine; Humans; Sulfides

1987
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
    European journal of biochemistry, 1986, May-15, Volume: 157, Issue:1

    Topics: Alanine; Amino Acids; Animals; Cattle; Cystathionine; Cysteine; Cystine; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Hydrogen-Ion Concentration; Kidney; Kinetics; Molecular Weight; Rats; Species Specificity; Structure-Activity Relationship; Substrate Specificity; Sulfides; Transaminases

1986
Metabolism of sulfur-containing amino acids in the dermatophyte Microsporum gypseum. I. Neutral amino acids.
    Journal of basic microbiology, 1985, Volume: 25, Issue:1

    Topics: Alanine; Amino Acids, Sulfur; Arginine; Chromatography, Thin Layer; Cysteine; Cystine; Homocystine; Hydrogen-Ion Concentration; Methionine; Microsporum; Sulfates; Sulfides; Sulfites

1985
Structural similarities of the staphylococcin-like peptide Pep-5 to the peptide antibiotic nisin.
    Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:5

    Topics: Alanine; Amino Acids; Bacteriocins; Carboxypeptidases; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Nisin; Staphylococcus epidermidis; Sulfides

1985
Studies on the utilization of lysinoalanine and lanthionine.
    The Journal of nutrition, 1980, Volume: 110, Issue:5

    Topics: Alanine; Amino Acids; Animals; Chickens; Cysteine; Dietary Proteins; Female; Hydrogen-Ion Concentration; Kidney; Lysine; Lysinoalanine; Male; Nutritive Value; Rats; Species Specificity; Structure-Activity Relationship; Sulfides

1980
Composition of peptidoglycans in Bacteroidaceae: determination and distribution of lanthionine.
    Infection and immunity, 1982, Volume: 36, Issue:1

    Topics: Alanine; Amino Acids; Bacteroidaceae; Bacteroides; Fusobacterium; Galactosamine; Glucosamine; Peptidoglycan; Stereoisomerism; Sulfides

1982
L-lanthionine oxidation by snake venom L-amino acid oxidase.
    Physiological chemistry and physics, 1982, Volume: 14, Issue:3

    Topics: Alanine; Amino Acid Oxidoreductases; Animals; Crotalid Venoms; L-Amino Acid Oxidase; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Snakes; Sulfides

1982
The tetracyclic lantibiotic actagardine. 1H-NMR and 13C-NMR assignments and revised primary structure.
    European journal of biochemistry, 1995, Mar-15, Volume: 228, Issue:3

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Carbon Isotopes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Peptides; Protons; Sulfides

1995
Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli.
    Journal of bacteriology, 1994, Volume: 176, Issue:14

    Topics: Alanine; Amino Acid Sequence; Cystathionine; Diaminopimelic Acid; Escherichia coli; Molecular Sequence Data; Mutation; Oligopeptides; Peptide Synthases; Peptidoglycan; Substrate Specificity; Sulfides

1994
Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.
    European journal of biochemistry, 1994, Mar-01, Volume: 220, Issue:2

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Bacteriocins; Circular Dichroism; Endopeptidases; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Structure, Secondary; Streptococcus pyogenes; Sulfides

1994
Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli.
    The Journal of biological chemistry, 1993, Dec-25, Volume: 268, Issue:36

    Topics: Alanine; Amino Acid Isomerases; Biological Evolution; Carbon-Oxygen Lyases; Cell Wall; Cystathionine; Diaminopimelic Acid; Escherichia coli; Lyases; Peptidoglycan; Racemases and Epimerases; Sulfides

1993
The mode of action of SA-FF22, a lantibiotic isolated from Streptococcus pyogenes strain FF22.
    European journal of biochemistry, 1994, Jan-15, Volume: 219, Issue:1-2

    Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Bacillus subtilis; Bacteriocins; Biological Transport; Cell Membrane; Kinetics; Membrane Potentials; Peptides; Phospholipids; Spectrometry, Fluorescence; Streptococcus; Streptococcus pyogenes; Sulfides

1994
Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3.
    Applied and environmental microbiology, 1993, Volume: 59, Issue:7

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA, Bacterial; Molecular Sequence Data; Plasmids; Streptococcus; Sulfides

1993
Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis.
    Applied and environmental microbiology, 1996, Volume: 62, Issue:5

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Bacteriocins; Base Sequence; Lactococcus lactis; Micrococcus; Molecular Sequence Data; Sequence Alignment; Sulfides

1996
Isolation of a new epidermin variant from two strains of Staphylococcus epidermidis--frequency of lantibiotic production in coagulase-negative staphylococci.
    Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1996, Volume: 284, Issue:2-3

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Coagulase; Genetic Variation; Mass Spectrometry; Molecular Sequence Data; Peptides; Staphylococcus epidermidis; Sulfides

1996
Effects of the lantibiotic mersacidin on the morphology of staphylococci.
    Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1996, Volume: 284, Issue:2-3

    Topics: Alanine; Anti-Bacterial Agents; Bacteriocins; Penicillins; Peptides; Staphylococcus; Sulfides; Tunicamycin; Vancomycin

1996
Proceedings of the 2nd International Workshop on Lantibiotics. Arnhem, The Netherlands, 20-23 November 1994.
    Antonie van Leeuwenhoek, 1996, Volume: 69, Issue:2

    Topics: Alanine; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Humans; Peptides; Sulfides

1996
Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.
    Journal of medicinal chemistry, 1997, Jul-04, Volume: 40, Issue:14

    Topics: Alanine; Animals; Biotransformation; Cells, Cultured; Drug Design; Growth Hormone; Male; Octreotide; Peptides, Cyclic; Pituitary Gland, Anterior; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Recombinant Proteins; Somatostatin; Spectrometry, Mass, Secondary Ion; Structure-Activity Relationship; Sulfides

1997
A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs.
    Journal of medicinal chemistry, 1997, Jul-04, Volume: 40, Issue:14

    Topics: Alanine; Amino Acid Sequence; Animals; Calorimetry; Humans; Isomerism; Magnetic Resonance Spectroscopy; Models, Molecular; Octreotide; Peptides, Cyclic; Protein Structure, Secondary; Receptors, Somatostatin; Structure-Activity Relationship; Sulfides; Threonine

1997
Simultaneous determination of urinary cystathionine, lanthionine, S-(2-aminoethyl)-L-cysteine and their cyclic compounds using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Sep-26, Volume: 698, Issue:1-2

    Topics: Alanine; Atmospheric Pressure; Chromatography, Ion Exchange; Cystathionine; Cysteine; Humans; Ions; Mass Spectrometry; Reference Values; Sulfides

1997
Underground metabolism.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1998, Volume: 20, Issue:2

    Topics: Alanine; Biological Evolution; Energy Metabolism; Enzymes; Genetic Diseases, Inborn; Glutamic Acid; Phenotype; Substrate Specificity; Sulfides

1998
Lanthionine macrocyclization by in situ activation of serine.
    The journal of peptide research : official journal of the American Peptide Society, 1998, Volume: 51, Issue:6

    Topics: Alanine; Amino Acids, Cyclic; Chromatography, High Pressure Liquid; Molecular Structure; Sequence Analysis; Serine; Sulfides

1998
Ab initio structure determination of the lantibiotic mersacidin.
    Acta crystallographica. Section D, Biological crystallography, 2000, Volume: 56, Issue:Pt 6

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Computer Simulation; Crystallization; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Peptides; Protein Conformation; Solutions; Static Electricity; Sulfides

2000
Biomimetic synthesis of lantibiotics.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2000, Apr-14, Volume: 6, Issue:8

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Peptides; Sulfides

2000
Synthesis, conformational analysis and biological activities of lanthionine analogs of a cell adhesion modulator.
    Journal of peptide science : an official publication of the European Peptide Society, 2001, Volume: 7, Issue:2

    Topics: Alanine; Cell Adhesion; Cell Adhesion Molecules; Computer Simulation; Humans; Inhibitory Concentration 50; Integrin alpha4beta1; Integrins; Magnetic Resonance Spectroscopy; Models, Chemical; Peptides; Platelet Aggregation; Protein Conformation; Receptors, Lymphocyte Homing; Sulfides

2001
Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.
    Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17

    Topics: Alanine; Analgesics; Animals; CHO Cells; Cricetinae; Enkephalins; Escape Reaction; Humans; Ileum; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfides; Swine; Vas Deferens

2002
NisB is required for the dehydration and NisC for the lanthionine formation in the post-translational modification of nisin.
    Microbiology (Reading, England), 2002, Volume: 148, Issue:Pt 11

    Topics: Alanine; Bacterial Proteins; Dehydration; Histidine; Lactococcus lactis; Membrane Proteins; Mutation; Nisin; Protein Processing, Post-Translational; Sulfides

2002
Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:2

    Topics: Alanine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord; Sulfides

2003
Enantioselective synthesis of alpha-methyl-D-cysteine and lanthionine building blocks via alpha-methyl-D-serine-beta-lactone.
    Organic letters, 2003, Apr-03, Volume: 5, Issue:7

    Topics: Alanine; Cysteine; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Serine; Sulfides

2003
[Studies on lanthionine formation from wool and cystine].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1956, May-28, Volume: 304, Issue:2-4

    Topics: Alanine; Amino Acids; Animals; Cystine; Sulfides; Wool

1956
Studies on the sulfur metabolism of tissues cultivated in vitro. IV. Ergothioneine, oxidized glutathione, and lanthionine.
    The Journal of biological chemistry, 1958, Volume: 231, Issue:1

    Topics: Alanine; Amino Acids; Cystine; Ergothioneine; Glutathione; Glutathione Disulfide; In Vitro Techniques; Myocardium; Sulfides; Sulfur

1958
An improved method for the determination of lanthionine.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1959, Volume: 48, Issue:6

    Topics: Alanine; Amino Acids; Sulfides

1959
Lanthionine formation in keratin.
    Nature, 1961, Jul-22, Volume: 191

    Topics: Alanine; Amino Acids; Biochemical Phenomena; Keratins; Sulfides

1961
[Decomposition of cystine, cysteine, cystine-dihydantoin, lanthionine and lanthionine-dihydantoin in aqueous solutions].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1962, Dec-15, Volume: 330

    Topics: Alanine; Amino Acids; Cysteine; Cystine; Hydantoins; Sulfides

1962
DETERMINATION OF LANTHIONINE IN PROTEIN HYDROLYZATES.
    Analytical biochemistry, 1964, Volume: 8

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chromatography; Cystine; Edetic Acid; Glutamates; Protein Hydrolysates; Research; Sulfides; Sulfonic Acids; Wool

1964
Utilization of sulfur compounds by Streptococcus bovis.
    Journal of bacteriology, 1961, Volume: 82

    Topics: Alanine; Amino Acids; Arginine; Cysteine; Methionine; Nitrogen; Streptococcus; Streptococcus bovis; Sulfates; Sulfides; Sulfites; Sulfur; Thiosulfates

1961
Synthesis of orthogonally protected lanthionines.
    The Journal of organic chemistry, 2003, Oct-17, Volume: 68, Issue:21

    Topics: Alanine; Anti-Bacterial Agents; Molecular Structure; Peptides; Stereoisomerism; Sulfides

2003
Synthesis of a cyclic peptide containing norlanthionine: effect of the thioether bridge on peptide conformation.
    The Journal of organic chemistry, 2003, Oct-17, Volume: 68, Issue:21

    Topics: Alanine; Bridged-Ring Compounds; Molecular Structure; Nisin; Peptides, Cyclic; Protein Conformation; Stereoisomerism; Sulfides

2003
Biomimetic studies on the mechanism of stereoselective lanthionine formation.
    Organic & biomolecular chemistry, 2003, Oct-07, Volume: 1, Issue:19

    Topics: Alanine; Amino Acid Sequence; Biomimetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Peptides; Selenocysteine; Stereoisomerism; Sulfides

2003
[On lanthionine formation; a contribution in explanation of priority in the isolation of a diaminothiopropionic acid from keratin].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1951, Volume: 286, Issue:3-6

    Topics: Alanine; Keratins; Sulfides

1951
A new procedure for the quantitative splitting of lanthionine to cysteine.
    Archives of biochemistry and biophysics, 1952, Volume: 35, Issue:2

    Topics: Alanine; Amino Acids; Cysteine; Sulfides

1952
Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.
    Biochemistry, 2004, Mar-23, Volume: 43, Issue:11

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Bacterial Proteins; Bacteriocins; Boranes; Deuterium; Drug Synergism; Lactococcus lactis; Molecular Sequence Data; Nickel; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peptide Fragments; Protein Conformation; Solutions; Structure-Activity Relationship; Sulfides; Sulfur; Thermodynamics

2004
Dehydroalanine crosslinks in human lens.
    Experimental eye research, 2004, Volume: 79, Issue:4

    Topics: Adult; Aged; Aging; Alanine; Cataract; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Crystallins; Dipeptides; Humans; Lens, Crystalline; Lysinoalanine; Middle Aged; Solubility; Sulfides

2004
An unusual mutation results in the replacement of diaminopimelate with lanthionine in the peptidoglycan of a mutant strain of Mycobacterium smegmatis.
    Journal of bacteriology, 2005, Volume: 187, Issue:5

    Topics: Alanine; Alleles; Amino Acid Sequence; Base Sequence; Cystathionine beta-Synthase; Diaminopimelic Acid; Molecular Sequence Data; Mutation; Mycobacterium smegmatis; Peptidoglycan; Sulfides

2005
Orthogonally protected lanthionines: synthesis and use for the solid-phase synthesis of an analogue of nisin ring C.
    The Journal of organic chemistry, 2005, Apr-01, Volume: 70, Issue:7

    Topics: Alanine; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Sulfides

2005
Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.
    Biochemistry, 2005, Jun-21, Volume: 44, Issue:24

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; DNA Primers; Drug Design; Lactococcus lactis; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Recombinant Proteins; Sulfides

2005
Glutathionylation of lens proteins through the formation of thioether bond.
    Molecular and cellular biochemistry, 2005, Volume: 272, Issue:1-2

    Topics: Aging; Alanine; Animals; Cattle; Crystallins; Glutathione; Glutathione Disulfide; Humans; Lens, Crystalline; Solutions; Sulfides

2005
Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli.
    Biochemical and biophysical research communications, 2005, Oct-21, Volume: 336, Issue:2

    Topics: Alanine; Amino Acid Sequence; Bacteriocins; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Hydro-Lyases; Molecular Sequence Data; Molecular Weight; Peptides; Protein Engineering; Recombinant Proteins; Sulfides

2005
SapT, a lanthionine-containing peptide involved in aerial hyphae formation in the streptomycetes.
    Molecular microbiology, 2005, Volume: 58, Issue:5

    Topics: Alanine; Bacterial Proteins; Culture Media; Gene Expression Regulation, Bacterial; Hyphae; Magnetic Resonance Spectroscopy; Models, Molecular; Morphogenesis; Mutation; Peptides; Streptomyces; Streptomyces coelicolor; Sulfides

2005
Lipolanthionine peptides act as inhibitors of TLR2-mediated IL-8 secretion. Synthesis and structure-activity relationships.
    Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5

    Topics: Adjuvants, Immunologic; Alanine; Cell Line; Fatty Acids; Gas Chromatography-Mass Spectrometry; Humans; Interleukin-8; Magnetic Resonance Spectroscopy; Oligopeptides; Stereoisomerism; Structure-Activity Relationship; Sulfides; Toll-Like Receptor 2

2006
Comparative species utilization and toxicity of sulfur amino acids.
    The Journal of nutrition, 2006, Volume: 136, Issue:6 Suppl

    Topics: Alanine; Amino Acids, Sulfur; Animals; Biological Availability; Cysteine; Cystine; Dietary Supplements; Glutathione; Homocysteine; Humans; Hydroxylation; Isomerism; Methionine; Species Specificity; Sulfides; Taurine; Vitamin U

2006
Stereoselective synthesis of orthogonally protected alpha-methylnorlanthionine.
    Organic letters, 2006, Jun-22, Volume: 8, Issue:13

    Topics: Alanine; Amino Acids; Catalysis; Cysteine; Molecular Structure; Nisin; Peptides, Cyclic; Stereoisomerism; Sulfides

2006
Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Aug-01, Volume: 177, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Alanine; Bacillus; beta-Defensins; Cell Line; Cell Line, Tumor; Corynebacterium; Cytokines; Diaminopimelic Acid; Epithelial Cells; HeLa Cells; Humans; Inflammation Mediators; Interferon-gamma; Intestinal Mucosa; Monocytes; Mouth Mucosa; Mycobacterium; Nod1 Signaling Adaptor Protein; Peptidoglycan; RNA, Messenger; RNA, Small Interfering; Stereoisomerism; Sulfides; Up-Regulation

2006
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.
    Chemistry & biology, 2006, Volume: 13, Issue:10

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Bacteriocins; Cyclization; Dehydration; Enzyme Activation; Enzymes; Molecular Conformation; Molecular Sequence Data; Mutation; Peptides; Protein Engineering; Sensitivity and Specificity; Sulfides

2006
Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.
    Organic & biomolecular chemistry, 2007, Mar-21, Volume: 5, Issue:6

    Topics: Alanine; Alkenes; Amino Acid Sequence; Catalysis; Chemistry, Organic; Mass Spectrometry; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Nisin; Peptides; Sulfides

2007
Rhenium analogues of promising renal imaging agents with a [99mTc(CO)3]+ core bound to cysteine-derived dipeptides, including lanthionine.
    Inorganic chemistry, 2007, Apr-16, Volume: 46, Issue:8

    Topics: Alanine; Crystallography, X-Ray; Cysteine; Dipeptides; Kidney; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Organometallic Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Rhenium; Sensitivity and Specificity; Sulfides

2007
A concise stereoselective synthesis of orthogonally protected lanthionine and beta-methyllanthionine.
    Organic & biomolecular chemistry, 2007, Apr-07, Volume: 5, Issue:7

    Topics: Alanine; Bacteriocins; Molecular Structure; Stereoisomerism; Sulfides

2007
Hair is the news.
    Molecular bioSystems, 2007, Volume: 3, Issue:7

    Topics: Alanine; Amino Acids; Ammonia; Animals; Cysteine; Hair; Hair Follicle; Humans; Sulfides

2007
Stereoselective syntheses of 4-oxa diaminopimelic acid and its protected derivatives via aziridine ring opening.
    Organic letters, 2007, Oct-11, Volume: 9, Issue:21

    Topics: Alanine; Amino Acids; Aziridines; Catalysis; Diaminopimelic Acid; Haemophilus influenzae; Molecular Structure; Racemases and Epimerases; Serine; Stereoisomerism; Sulfides; Threonine

2007
Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.
    Molecular immunology, 2008, Volume: 45, Issue:6

    Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Animals, Newborn; Cell Line; Cloning, Molecular; Diaminopimelic Acid; Humans; Molecular Sequence Data; Nod1 Signaling Adaptor Protein; Peyer's Patches; Stereoisomerism; Sulfides; Swine

2008
Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Alanine; Anti-Bacterial Agents; Bacteriocins; Cell Membrane; Coated Vesicles; Diphosphates; Fluoresceins; Lactococcus lactis; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Peptides; Phosphatidylcholines; Phosphatidylglycerols; Succinic Acid; Sulfides; Tryptophan; Uridine Diphosphate N-Acetylmuramic Acid

2008
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
    Biochemistry, 2008, Jul-15, Volume: 47, Issue:28

    Topics: 5' Untranslated Regions; Alanine; Amino Acid Sequence; Aminobutyrates; Bacteriocins; Conserved Sequence; DNA Primers; Enzymes; Gene Expression; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Sequence Alignment; Sulfides

2008
Complete covalent structure of nisin Q, new natural nisin variant, containing post-translationally modified amino acids.
    Bioscience, biotechnology, and biochemistry, 2008, Volume: 72, Issue:7

    Topics: Alanine; Amino Acid Substitution; Anti-Bacterial Agents; Bacteriocins; Magnetic Resonance Spectroscopy; Molecular Structure; Nisin; Protein Processing, Post-Translational; Sulfides

2008
The availability of dl-lanthionine for the promotion of growth in young rats when added to a cystine- and methionine-deficient diet.
    The Journal of biological chemistry, 1948, Volume: 176, Issue:1

    Topics: Alanine; Animals; Cystine; Diet; Methionine; Rats; Sulfides

1948
Availability of dl-lanthionine for the promotion of growth when added to a cystine-deficient diet.
    Federation proceedings, 1948, Volume: 7, Issue:1 Pt 1

    Topics: Alanine; Cystine; Diet; Growth; Humans; Sulfides

1948
Concise preparation of tetra-orthogonally protected (2S,6R)-lanthionines.
    The Journal of organic chemistry, 2009, Jan-16, Volume: 74, Issue:2

    Topics: Alanine; Bacteriocins; Stereoisomerism; Sulfides

2009
Oxidation of lanthionines renders the lantibiotic nisin inactive.
    Applied and environmental microbiology, 2009, Volume: 75, Issue:5

    Topics: Alanine; Anti-Bacterial Agents; Macromolecular Substances; Mass Spectrometry; Microbial Sensitivity Tests; Micrococcus luteus; Microscopy, Electron; Models, Molecular; Nisin; Oxidation-Reduction; Staphylococcus aureus; Streptococcus pneumoniae; Sulfides; Uridine Diphosphate N-Acetylmuramic Acid

2009
Characterization of alkali induced formation of lanthionine, trisulfides, and tetrasulfides from peptide disulfides using negative ion mass spectrometry.
    Journal of the American Society for Mass Spectrometry, 2009, Volume: 20, Issue:5

    Topics: Alanine; Glutathione Disulfide; Peptides, Cyclic; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds; Sulfides

2009
Two novel bovine somatotropin species generated from a common dehydroalanine intermediate.
    The protein journal, 2009, Volume: 28, Issue:2

    Topics: Alanine; Amino Acid Sequence; Animals; Cattle; Chromatography, Ion Exchange; Growth Hormone; Hydrogen-Ion Concentration; Lysinoalanine; Molecular Sequence Data; Peptide Mapping; Protein Conformation; Protein Multimerization; Sequence Analysis, Protein; Sulfides; Tandem Mass Spectrometry

2009
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.
    The Journal of biological chemistry, 2009, Apr-24, Volume: 284, Issue:17

    Topics: Alanine; Catalysis; Cystathionine gamma-Lyase; Cysteine; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Hyperhomocysteinemia; Kinetics; Mass Spectrometry; Models, Chemical; Recombinant Proteins; Sulfides; Sulfur; Temperature

2009
Chapter 21. In vitro studies of lantibiotic biosynthesis.
    Methods in enzymology, 2009, Volume: 458

    Topics: Alanine; Aminobutyrates; Bacteriocins; Molecular Structure; Sulfides

2009
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.
    The Journal of biological chemistry, 2009, Aug-14, Volume: 284, Issue:33

    Topics: Alanine; Chromatography, High Pressure Liquid; Computer Simulation; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Humans; Hydrogen Sulfide; Kinetics; Mass Spectrometry; Models, Biological; Models, Chemical; Molecular Conformation; Serine; Sulfides; Sulfur

2009
Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin.
    The Journal of biological chemistry, 2009, Sep-18, Volume: 284, Issue:38

    Topics: Alanine; Anti-Bacterial Agents; Bacterial Proteins; Lactococcus lactis; Membrane Proteins; Multienzyme Complexes; Nisin; Peptide Biosynthesis, Nucleic Acid-Independent; Sulfides

2009
Commentary: healthy hair and protein loss.
    Journal of the American Academy of Dermatology, 2010, Volume: 62, Issue:3

    Topics: Alanine; Carbonates; Cystine; Guanidine; Hair; Hair Diseases; Hair Preparations; Lye; Proteins; Scalp Dermatoses; Sulfides

2010
The action of formaldehyde on the cystine disulphide linkage of wool; the conversion of subfraction A of the combined cystine into combined lanthionine and djenkolic acid and subfraction B into combined thiazolidine-4-carboxylic acid.
    The Biochemical journal, 1947, Volume: 41, Issue:2

    Topics: Alanine; Animals; Cysteine; Cystine; Formaldehyde; Humans; Sulfides; Thiazolidines; Wool

1947
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights.
    PLoS biology, 2010, Mar-23, Volume: 8, Issue:3

    Topics: Alanine; Amino Acid Sequence; Bacteria; Bacterial Proteins; Bacteriocins; Evolution, Molecular; Isoenzymes; Ligases; Molecular Sequence Data; Molecular Structure; Multigene Family; Phylogeny; Protein Conformation; Protein Processing, Post-Translational; RNA, Ribosomal, 16S; Sequence Alignment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptomyces; Sulfides

2010
Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586.
    Microbiology (Reading, England), 2010, Volume: 156, Issue:Pt 7

    Topics: Alanine; Ammonia; Aspartate Aminotransferases; Bacterial Proteins; Cysteine Synthase; Fusobacterium nucleatum; Homocysteine; Hydrogen Sulfide; Kinetics; Pyruvic Acid; Substrate Specificity; Sulfides

2010
The kinetics of β-elimination of cystine and the formation of lanthionine in gliadin.
    Journal of agricultural and food chemistry, 2010, Oct-13, Volume: 58, Issue:19

    Topics: Alanine; Cystine; Disulfides; Gliadin; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Sulfides

2010
Effect of bioengineering lacticin 3147 lanthionine bridges on specific activity and resistance to heat and proteases.
    Chemistry & biology, 2010, Oct-29, Volume: 17, Issue:10

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Bacteriocins; Bioengineering; Hot Temperature; Peptide Hydrolases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides

2010
Ruminococcin C, a new anti-Clostridium perfringens bacteriocin produced in the gut by the commensal bacterium Ruminococcus gnavus E1.
    Biochimie, 2011, Volume: 93, Issue:9

    Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Bacteriocins; Cecum; Clostridium perfringens; Genes, Bacterial; Hot Temperature; Hydrogen-Ion Concentration; Intestines; Microbial Sensitivity Tests; Molecular Sequence Data; Rats; Ruminococcus; Sulfides

2011
Application of XANES profiles to X-ray spectromicroscopy for biomedical specimens: Part I. Discrimination of macromolecules with sulfur atoms.
    Journal of X-ray science and technology, 2011, Volume: 19, Issue:2

    Topics: Alanine; Animals; Cattle; Cysteine; Cystine; Glutathione; Hemoglobins; Histones; Macromolecular Substances; Methionine; Molecular Conformation; Serum Albumin, Bovine; Spectrometry, X-Ray Emission; Sulfides; Sulfur Compounds

2011
Synthesis of peptides containing overlapping lanthionine bridges on the solid phase: an analogue of rings D and E of the lantibiotic nisin.
    Organic letters, 2011, Aug-19, Volume: 13, Issue:16

    Topics: Alanine; Amino Acid Sequence; Nisin; Peptides; Sulfides

2011
Cross-linking of wheat gluten proteins during production of hard pretzels.
    Amino acids, 2012, Volume: 42, Issue:6

    Topics: Alanine; Chromatography, Ion Exchange; Cross-Linking Reagents; Cysteine; Cystine; Food Handling; Food Technology; Glutens; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Lysinoalanine; Maillard Reaction; Reducing Agents; Sodium Dodecyl Sulfate; Sodium Hydroxide; Sulfides; Triticum

2012
A biomimetic approach to lanthionines.
    Organic letters, 2012, Jan-06, Volume: 14, Issue:1

    Topics: Alanine; Amino Acids; Biomimetic Materials; Molecular Structure; Stereoisomerism; Sulfides

2012
Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing.
    Chembiochem : a European journal of chemical biology, 2012, May-29, Volume: 13, Issue:8

    Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Genes, Bacterial; Mass Spectrometry; Molecular Sequence Data; Saccharopolyspora; Streptomyces; Streptomyces griseus; Sulfides

2012
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria.
    Biochemistry, 2012, May-29, Volume: 51, Issue:21

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Gas Chromatography-Mass Spectrometry; Genes, Bacterial; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Prochlorococcus; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Stereoisomerism; Sulfides

2012
Biosynthesis of the class III lantipeptide catenulipeptin.
    ACS chemical biology, 2012, Sep-21, Volume: 7, Issue:9

    Topics: Actinobacteria; Alanine; Amino Acid Sequence; Genes, Bacterial; Molecular Sequence Data; Multigene Family; Peptides; Protein Sorting Signals; Streptomyces coelicolor; Sulfides

2012
Curvopeptin: a new lanthionine-containing class III lantibiotic and its co-substrate promiscuous synthetase.
    Chembiochem : a European journal of chemical biology, 2012, Sep-24, Volume: 13, Issue:14

    Topics: Actinomycetales; Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Biological Products; Chromatography, High Pressure Liquid; Ligases; Mass Spectrometry; Molecular Sequence Data; Multigene Family; Peptides, Cyclic; Protein Precursors; Substrate Specificity; Sulfides

2012
Characterization of therapeutic monoclonal antibodies reveals differences between in vitro and in vivo time-course studies.
    Pharmaceutical research, 2013, Volume: 30, Issue:1

    Topics: Alanine; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Chromatography, Liquid; Humans; Immunoglobulin G; Lysine; Pyrrolidonecarboxylic Acid; Rats; Sulfides; Tandem Mass Spectrometry

2013
The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry.
    Nature chemical biology, 2013, Volume: 9, Issue:3

    Topics: Alanine; Enterococcus; Molecular Conformation; Perforin; Stereoisomerism; Sulfides

2013
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
    Antioxidants & redox signaling, 2013, Oct-20, Volume: 19, Issue:12

    Topics: Alanine; Animals; Cystathionine; Cysteine; Cysteine Dioxygenase; Diet; Electron Transport Complex IV; Enzyme Stability; Female; Glutathione; Hydrogen Sulfide; Kidney; Liver; Lung; Male; Mice; Mice, Knockout; Organ Specificity; Pancreas; Sulfides; Taurine

2013
Characterization of the congeners in the lantibiotic NAI-107 complex.
    Journal of natural products, 2014, Jan-24, Volume: 77, Issue:1

    Topics: Actinomycetales; Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Drug Resistance, Bacterial; Molecular Structure; Multigene Family; Sulfides

2014
Novel LanT associated lantibiotic clusters identified by genome database mining.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Actinobacteria; Alanine; Anti-Bacterial Agents; Bacterial Proteins; Biological Transport; Data Mining; Databases, Genetic; Genes, Bacterial; Genomics; Multigene Family; Quorum Sensing; Sulfides

2014
Effects of pH and lactate on hydrogen sulfide production by oral Veillonella spp.
    Applied and environmental microbiology, 2014, Volume: 80, Issue:14

    Topics: Alanine; Ammonia; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Lactic Acid; Serine; Sulfides; Veillonella

2014
Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM.
    Journal of the American Chemical Society, 2014, Jul-23, Volume: 136, Issue:29

    Topics: Alanine; Amino Acid Sequence; Bacteriocins; Biocatalysis; Cyclization; Ligases; Molecular Sequence Data; Peptides, Cyclic; Prochlorococcus; Protein Processing, Post-Translational; Solid-Phase Synthesis Techniques; Substrate Specificity; Sulfides

2014
Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli.
    Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17

    Topics: Alanine; Escherichia coli; Molecular Structure; Peptidoglycan; Solutions; Stereoisomerism; Sulfides; Water

2014
Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells.
    The Journal of nutrition, 2014, Volume: 144, Issue:10

    Topics: Alanine; Biomarkers; Carcinoma, Hepatocellular; Cysteine; Hep G2 Cells; Homocysteine; Humans; Hydrogen Sulfide; Linear Models; Liver Neoplasms; Pyridoxal Phosphate; Sulfides; Vitamin B 6; Vitamin B 6 Deficiency

2014
Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.
    Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19

    Topics: Alanine; Anti-Bacterial Agents; Bacillus subtilis; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Conformation; Nisin; Structure-Activity Relationship; Sulfides

2014
Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids.
    Journal of the American Chemical Society, 2014, Sep-24, Volume: 136, Issue:38

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacteriocins; Carnobacteriaceae; Enterococcus; Methylation; Molecular Sequence Data; Perforin; Sulfides

2014
High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis.
    ACS chemical biology, 2014, Nov-21, Volume: 9, Issue:11

    Topics: Alanine; Amino Acid Sequence; Combinatorial Chemistry Techniques; Molecular Sequence Data; Peptides; Sequence Homology, Amino Acid; Sulfides

2014
Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.
    Molecular biology of the cell, 2014, Dec-01, Volume: 25, Issue:24

    Topics: Alanine; Apoptosis; Blotting, Western; Cell Line, Transformed; Cell Survival; HEK293 Cells; Hep G2 Cells; Humans; Mechanistic Target of Rapamycin Complex 2; Membrane Proteins; Microscopy, Fluorescence; Multiprotein Complexes; Nuclear Proteins; Phosphate-Binding Proteins; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; RNA Interference; Sulfides; TOR Serine-Threonine Kinases

2014
Enantioselective synthesis of α-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan.
    Organic & biomolecular chemistry, 2014, Dec-28, Volume: 12, Issue:48

    Topics: Alanine; Escherichia coli; Molecular Structure; Oligopeptides; Peptidoglycan; Stereoisomerism; Sulfides

2014
A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.
    Journal of the American Chemical Society, 2014, Dec-17, Volume: 136, Issue:50

    Topics: Alanine; Biological Assay; Kinetics; Ligases; Models, Molecular; Molecular Structure; Peptides; Protein Processing, Post-Translational; Substrate Specificity; Sulfides

2014
Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.
    Chembiochem : a European journal of chemical biology, 2015, Jan-19, Volume: 16, Issue:2

    Topics: Alanine; Antineoplastic Agents; Apoptosis; Chemistry Techniques, Synthetic; Dimerization; Disulfides; Humans; Lymphoma; Magnetic Resonance Spectroscopy; Molecular Targeted Therapy; Peptides, Cyclic; Protein Conformation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sulfides; Surface Plasmon Resonance

2015
Natural product biosynthesis: the road to L.
    Nature chemistry, 2015, Volume: 7, Issue:1

    Topics: Alanine; Sulfides

2015
Substrate control in stereoselective lanthionine biosynthesis.
    Nature chemistry, 2015, Volume: 7, Issue:1

    Topics: Alanine; Amino Acid Sequence; Cyclization; Gas Chromatography-Mass Spectrometry; Molecular Sequence Data; Protein Structure, Secondary; Quantum Theory; Stereoisomerism; Substrate Specificity; Sulfides; Thermodynamics

2015
GRPR-selective PET imaging of prostate cancer using [(18)F]-lanthionine-bombesin analogs.
    Peptides, 2015, Volume: 67

    Topics: Alanine; Animals; Bombesin; Cell Line, Tumor; Fluorine Radioisotopes; Humans; Male; Mice, Nude; Neoplasm Transplantation; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Bombesin; Sulfides; Tissue Distribution; X-Ray Microtomography

2015
Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria.
    Applied and environmental microbiology, 2015, Volume: 81, Issue:13

    Topics: Actinobacteria; Alanine; Biological Products; Biosynthetic Pathways; Multigene Family; Sulfides

2015
In vitro catalytic activity of N-terminal and C-terminal domains in NukM, the post-translational modification enzyme of nukacin ISK-1.
    Journal of bioscience and bioengineering, 2015, Volume: 120, Issue:6

    Topics: Alanine; Bacteriocins; Biocatalysis; Cyclization; Enzymes; Nisin; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Staphylococcus; Substrate Specificity; Sulfides

2015
Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365.
    Chembiochem : a European journal of chemical biology, 2015, Volume: 16, Issue:18

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; Molecular Sequence Data; Multigene Family; Peptides; Promoter Regions, Genetic; Protein Structure, Secondary; Sequence Alignment; Streptomyces; Sulfides; Tandem Mass Spectrometry

2015
Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency.
    Journal of natural products, 2015, Nov-25, Volume: 78, Issue:11

    Topics: Actinobacteria; Actinomycetales; Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Gram-Positive Bacteria; Hydrocarbons, Brominated; Microbial Sensitivity Tests; Microsporidia; Molecular Structure; Peptides; Sulfides

2015
Identification of lanthionine and lysinoalanine in heat-treated wheat gliadin and bovine serum albumin using tandem mass spectrometry with higher-energy collisional dissociation.
    Amino acids, 2016, Volume: 48, Issue:4

    Topics: Alanine; Animals; Cattle; Chymotrypsin; Cysteine; Cystine; Gliadin; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Lysinoalanine; Proteolysis; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides; Threonine; Triticum; Trypsin

2016
Thioethers as markers of hydrogen sulfide production in homocystinurias.
    Biochimie, 2016, Volume: 126

    Topics: Alanine; Cells, Cultured; Cystathionine; Cystathionine beta-Synthase; Female; Fibroblasts; Homocystinuria; Humans; Hydrogen Sulfide; Male; Sulfides

2016
Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic.
    Journal of the American Chemical Society, 2016, 04-27, Volume: 138, Issue:16

    Topics: Alanine; Animals; Anti-Bacterial Agents; Bacillus cereus; Bacteriocins; Cysteine; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxidoreductases; Peptides; Protein Sorting Signals; Rabbits; Recombinant Proteins; Sulfides; Vancomycin-Resistant Enterococci

2016
Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM.
    Biopolymers, 2016, Volume: 106, Issue:6

    Topics: Alanine; Bacteriocins; Escherichia coli; Peptide Synthases; Sulfides

2016
The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis.
    ACS chemical biology, 2016, 09-16, Volume: 11, Issue:9

    Topics: Alanine; Enterococcus; Ligases; Perforin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Substrate Specificity; Sulfides

2016
The Myeloablative Drug Busulfan Converts Cysteine to Dehydroalanine and Lanthionine in Redoxins.
    Biochemistry, 2016, 08-23, Volume: 55, Issue:33

    Topics: Alanine; Busulfan; Cysteine; Humans; Myeloablative Agonists; Sulfides; Tandem Mass Spectrometry

2016
LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.
    Scientific reports, 2017, 01-20, Volume: 7

    Topics: Alanine; Animals; Brain Chemistry; Mass Spectrometry; Membrane Proteins; Mice; Mice, Knockout; Phosphate-Binding Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfides

2017
Recognizing and Predicting Thioether Bridges Formed by Lanthionine and β-Methyllanthionine in Lantibiotics Using a Random Forest Approach with Feature Selection.
    Combinatorial chemistry & high throughput screening, 2017, Volume: 20, Issue:7

    Topics: Alanine; Bacteriocins; Databases, Protein; Machine Learning; Sulfides

2017
Evolutionary radiation of lanthipeptides in marine cyanobacteria.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 07-03, Volume: 114, Issue:27

    Topics: Alanine; Bayes Theorem; Biological Products; Cluster Analysis; Computational Biology; Cyanobacteria; Evolution, Molecular; Genetic Variation; Genome; Monte Carlo Method; Peptides; Peptides, Cyclic; Photosynthesis; Phylogeny; Polymerase Chain Reaction; Prochlorococcus; Sulfides; Synechococcus

2017
Substrate Specificity of the Secreted Nisin Leader Peptidase NisP.
    Biochemistry, 2017, 08-01, Volume: 56, Issue:30

    Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Anti-Bacterial Agents; Bacterial Proteins; Biocatalysis; Enzyme Activation; Lactococcus lactis; Membrane Proteins; Methylation; Molecular Weight; Mutagenesis, Site-Directed; Mutation; Nisin; Peptide Fragments; Protein Processing, Post-Translational; Protein Sorting Signals; Proteolysis; Recombinant Proteins; Substrate Specificity; Subtilisins; Sulfides

2017
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase.
    Antioxidants & redox signaling, 2018, 02-01, Volume: 28, Issue:4

    Topics: Alanine; Animals; Biomarkers; Catalysis; Cystathionine beta-Synthase; Cysteine; Haplorhini; Homocysteine; Hydrogen Sulfide; Kinetics; Mice; Mice, Knockout; Serine; Sulfides; Sulfur

2018
Electron transfer dissociation of synthetic and natural peptides containing lanthionine/methyllanthionine bridges.
    Rapid communications in mass spectrometry : RCM, 2018, Jun-15, Volume: 32, Issue:11

    Topics: Alanine; Cyanogen Bromide; Disulfides; Electron Transport; Nisin; Peptides; Sulfides; Tandem Mass Spectrometry

2018
Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine.
    International journal of molecular sciences, 2018, Apr-29, Volume: 19, Issue:5

    Topics: Alanine; Animals; Disease Models, Animal; Organogenesis; Sulfides; Toxins, Biological; Uremia; Xenobiotics; Zebrafish

2018
The Enzymology of Prochlorosin Biosynthesis.
    Methods in enzymology, 2018, Volume: 604

    Topics: Alanine; Alkynes; Aquatic Organisms; Cyanobacteria; Cyclization; Cysteine; Kinetics; Peptides; Prochlorococcus; Protein Engineering; Recombinant Proteins; Substrate Specificity; Sulfides; Zinc

2018
Advanced glycation end products, protein crosslinks and post translational modifications in pork subjected to different heat treatments.
    Meat science, 2018, Volume: 145

    Topics: Alanine; Animals; Cooking; Dietary Proteins; Glycation End Products, Advanced; Hot Temperature; Humans; Lysine; Maillard Reaction; Muscle Proteins; Nutritive Value; Peptides; Protein Processing, Post-Translational; Protein Stability; Red Meat; Sulfides; Swine; Taste

2018
A Late-Stage Synthetic Approach to Lanthionine-Containing Peptides via S-Alkylation on Cyclic Sulfamidates Promoted by Molecular Sieves.
    Organic letters, 2018, 12-07, Volume: 20, Issue:23

    Topics: Alanine; Alkylation; Molecular Conformation; Peptides; Sulfides; Sulfonic Acids

2018
Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models.
    Peptides, 2019, Volume: 112

    Topics: Alanine; Angiotensin I; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Insulin; Mice; Mice, Inbred C57BL; Peptide Fragments; Streptozocin; Sulfides; Treatment Outcome

2019
Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale.
    Nature chemical biology, 2019, Volume: 15, Issue:5

    Topics: Alanine; Anti-Bacterial Agents; Bacteria; Drug Design; Microbial Sensitivity Tests; Peptides; Protein Engineering; Sulfides

2019
Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications.
    ACS synthetic biology, 2019, 05-17, Volume: 8, Issue:5

    Topics: Alanine; Amino Acid Sequence; Cyclization; Mutagenesis, Site-Directed; Oligopeptides; Peptides, Cyclic; Protein Engineering; Protein Processing, Post-Translational; Sulfides

2019
Uremic Toxin Lanthionine Interferes with the Transsulfuration Pathway, Angiogenetic Signaling and Increases Intracellular Calcium.
    International journal of molecular sciences, 2019, May-08, Volume: 20, Issue:9

    Topics: Alanine; Amino Acids, Sulfur; Calcium; Cell Line; Cystathionine beta-Synthase; Endothelial Cells; Flow Cytometry; Gene Expression Regulation; Glutathione; Humans; Hydrogen Sulfide; MicroRNAs; Neovascularization, Physiologic; Oxidation-Reduction; Renal Insufficiency, Chronic; Sulfides; Uremia; Vascular Endothelial Growth Factor A

2019
Addition of cyclic angiotensin-(1-7) to angiotensin-converting enzyme inhibitor therapy has a positive add-on effect in experimental diabetic nephropathy.
    Kidney international, 2019, Volume: 96, Issue:4

    Topics: Alanine; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Drug Therapy, Combination; Half-Life; Humans; Kidney Glomerulus; Lisinopril; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Peptide Fragments; Peptides, Cyclic; Proteinuria; Sulfides

2019
Structural and Kinetic Insight into the Biosynthesis of H
    Biochemistry, 2019, 08-27, Volume: 58, Issue:34

    Topics: Alanine; Bacterial Proteins; Cystathionine beta-Synthase; Cysteine; Cysteine Synthase; Fusobacterium nucleatum; Humans; Hydro-Lyases; Hydrogen Sulfide; Kinetics; Multienzyme Complexes; Protein Conformation; Pyridoxal Phosphate; Structure-Activity Relationship; Sulfides; Yeasts

2019
    Journal of the American Chemical Society, 2019, 10-23, Volume: 141, Issue:42

    Topics: Alanine; Amino Acid Sequence; Biocatalysis; Imides; Methyltransferases; Models, Molecular; Peptides; Protein Conformation; Streptomyces; Sulfides

2019
Lanthionine Peptides by
    The Journal of organic chemistry, 2019, 11-15, Volume: 84, Issue:22

    Topics: Alanine; Alkylation; Molecular Structure; Peptides; Sulfides; Sulfonic Acids

2019
Whole genome mining reveals a diverse repertoire of lanthionine synthetases and lanthipeptides among the genus Paenibacillus.
    Journal of applied microbiology, 2020, Volume: 128, Issue:2

    Topics: Alanine; Bacterial Proteins; Genome, Bacterial; Ligases; Multigene Family; Paenibacillus; Peptides; Sulfides

2020
Boiling down the cysteine-stabilized LTP fold - loss of structural and immunological integrity of allergenic Art v 3 and Pru p 3 as a consequence of irreversible lanthionine formation.
    Molecular immunology, 2019, Volume: 116

    Topics: Alanine; Amino Acid Sequence; Animals; Antigens, Plant; Artemisia; Carrier Proteins; Cross Reactions; Cysteine; Epitopes; Escherichia coli; Food Hypersensitivity; Humans; Immunoglobulin E; Immunoglobulin G; Mice; Plant Proteins; Pollen; Prunus; Sulfides

2019
Roseocin, a novel two-component lantibiotic from an actinomycete.
    Molecular microbiology, 2020, Volume: 113, Issue:2

    Topics: Actinobacteria; Alanine; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Escherichia coli; Genome, Bacterial; Multigene Family; Recombinant Proteins; Streptomyces; Sulfides

2020
Complete synthesis of the bicyclic ring of a mutacin analog with orthogonally protected lanthionine via solid-phase intracyclization.
    Journal of peptide science : an official publication of the European Peptide Society, 2019, Volume: 25, Issue:11

    Topics: Alanine; Bacteriocins; Molecular Conformation; Solid-Phase Synthesis Techniques; Sulfides

2019
High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB.
    ACS synthetic biology, 2020, 06-19, Volume: 9, Issue:6

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; High-Throughput Screening Assays; Lactococcus lactis; Ligands; Membrane Proteins; Mutagenesis, Site-Directed; Peptides; Protein Binding; Streptavidin; Substrate Specificity; Sulfides

2020
Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Adult; Alanine; Arginine; Carnitine; Case-Control Studies; Diabetes, Gestational; Diet Therapy; Dopamine; Early Diagnosis; Epigenesis, Genetic; Female; Fetal Development; Gestational Age; Glucose Tolerance Test; Glucuronides; Humans; Hypoglycemic Agents; Lactones; Lysine; Meglutol; Metabolomics; Neopterin; Orotic Acid; Phenols; Pregnancy; Ribonucleosides; Sulfides

2021
Genomic analysis suggests Salinispora is a rich source of novel lanthipeptides.
    Molecular genetics and genomics : MGG, 2020, Volume: 295, Issue:6

    Topics: Alanine; Bacterial Proteins; Genome, Bacterial; Genomics; Micromonosporaceae; Peptide Fragments; Sulfides

2020
LP2, the first lanthipeptide GPCR agonist in a human pharmacokinetics and safety study.
    Peptides, 2021, Volume: 136

    Topics: Alanine; Angiotensin I; Animals; Arthropod Proteins; Dogs; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Oligopeptides; Peptide Fragments; Peptides; Proteolysis; Rats; Receptors, G-Protein-Coupled; Sulfides

2021
LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome.
    Cell, 2021, 05-13, Volume: 184, Issue:10

    Topics: Alanine; Aminobutyrates; Animals; Antimicrobial Cationic Peptides; Female; Glutathione; HEK293 Cells; Humans; Male; MAP Kinase Kinase 1; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Phosphate-Binding Proteins; Phosphorylation; Protein Domains; Proteome; Receptors, G-Protein-Coupled; Sulfides

2021
Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides.
    Angewandte Chemie (International ed. in English), 2021, 07-19, Volume: 60, Issue:30

    Topics: Alanine; Computational Biology; Data Mining; Genome, Bacterial; Isotopes; Magnetic Resonance Spectroscopy; Multigene Family; Nocardia; Peptides; Protein Conformation; Protein Processing, Post-Translational; Ribosomes; Sulfides; Tandem Mass Spectrometry; Thioamides

2021
Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies.
    ACS synthetic biology, 2021, 10-15, Volume: 10, Issue:10

    Topics: Alanine; Amino Acids; Cloning, Molecular; Cyclization; Lactococcus lactis; Ligases; Peptides; Protein Conformation; Substrate Specificity; Sulfides

2021
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides.
    Molecules (Basel, Switzerland), 2021, Oct-11, Volume: 26, Issue:20

    Topics: Alanine; Alkylation; Aziridines; Catalysis; Chromatography, Gel; Chromatography, Liquid; Cysteine; Heating; Microwaves; Molecular Structure; Peptides; Sulfides

2021
Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM.
    Journal of the American Chemical Society, 2021, 11-10, Volume: 143, Issue:44

    Topics: Alanine; Amino Acid Sequence; Models, Molecular; Peptides; Protein Conformation; Sulfides

2021
Mechanistic Studies on Dehydration in Class V Lanthipeptides.
    ACS chemical biology, 2022, 09-16, Volume: 17, Issue:9

    Topics: Alanine; Bacteriocins; Dehydration; Kanamycin Kinase; Ligases; Lyases; Peptides; Phosphates; Protein Sorting Signals; Sulfides

2022
Modular Use of the Uniquely Small Ring A of Mersacidin Generates the Smallest Ribosomally Produced Lanthipeptide.
    ACS synthetic biology, 2022, 09-16, Volume: 11, Issue:9

    Topics: Alanine; Bacteriocins; Peptides; Sulfides

2022
Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product.
    Journal of the American Chemical Society, 2022, 09-28, Volume: 144, Issue:38

    Topics: Alanine; Bacteriocins; Biological Products; Peptides; Peptides, Cyclic; Sulfides

2022
CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells.
    Scientific reports, 2023, 02-13, Volume: 13, Issue:1

    Topics: Alanine; Animals; Artificial Cells; Autophagy; Mammals; Microtubule-Associated Proteins; Motor Neurons

2023