alanine has been researched along with kainic acid in 52 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (13.46) | 18.7374 |
1990's | 14 (26.92) | 18.2507 |
2000's | 23 (44.23) | 29.6817 |
2010's | 8 (15.38) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Davies, J; Evans, RH; Francis, AA; Watkins, JC | 1 |
Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC | 1 |
Bockaert, J; Do, E; Manzoni, OJ; Poulat, F; Sahuquet, A; Sassetti, I; Sladeczek, FA | 1 |
Bowie, D; Smart, TG | 2 |
Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
Ross, SM; Roy, DN; Spencer, PS | 1 |
Johnson, BG; Schoepp, DD | 1 |
Walker, JB; Woznicki, DT | 1 |
Shinozaki, H | 1 |
Ishida, M; Shinozaki, H | 1 |
Davies, J; Evans, RH; Francis, AA; Jones, AW; Watkins, JC | 1 |
Bregnedal, P; Brehm, L; Bøgesø, KP; Ebert, B; Frederiksen, K; Hansen, JJ; Krogsgaard-Larsen, P; Lenz, S | 1 |
Jane, DE; Mayer, ML; Watkins, JC; Wong, LA | 1 |
Honoré, T; Sheardown, MJ; Suzdak, PD | 1 |
Mayer, ML; Wong, LA | 1 |
Fu, WM; Liou, HC; Yang, RS | 1 |
Butterworth, RF; Michalak, A | 1 |
Fariello, RG; Maj, R; McArthur, RA; Pevarello, P; Salvati, P; Ukmar, G; Varasi, M | 1 |
Banno, T; Kohno, K | 1 |
Cui, C; Mayer, ML | 1 |
Behan, WM; Stone, TW | 1 |
Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
Kimmich, GA; Manglapus, M; Randles, J; Roussie, J | 1 |
Henley, JM; Olivera, S; Rodriguez-Ithurralde, D | 1 |
Clippe, A; Gressens, P; Knoops, B; Plaisant, F; Vander Stricht, D | 1 |
Gouaux, E; Jin, R | 1 |
Callewaert, G; Leyssen, M; Robberecht, W; Van Damme, P; Van Den Bosch, L | 1 |
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
Albo, F; Bernardi, G; Ferrari, F; Longone, P; Mercuri, N; Spalloni, A; Zona, C | 1 |
Alt, AJ; Bleakman, D; Bortolotto, ZA; Buelens, FP; Clarke, VR; Collingridge, GL; Dolman, NP; Jane, DE; Kelland, EE; More, JC; Nistico, R; Ogden, AM; Pilato, F; Troop, HM | 1 |
Hesp, BR; Kerr, DS; Mullaney, I; Wrightson, T | 1 |
Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B | 1 |
Ito, K; Johnson, MS; Pentikäinen, OT; Sakai, R; Sanders, JM; Sasaki, M; Settimo, L; Shoji, M; Swanson, GT | 1 |
Egebjerg, J; Gajhede, M; Geballe, MT; Holm, MM; Kastrup, JS; Naur, P; Traynelis, SF; Vestergaard, B | 1 |
Frerking, M; Partovi, D | 1 |
Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P | 1 |
Bunch, L; Krogsgaard-Larsen, P | 1 |
Green, T; Nayeem, N; Zhang, Y | 1 |
Jane, DE; Mulle, C; Perrais, D; Pinheiro, PS | 1 |
Ahmed, AH; Fenwick, MK; Jane, DE; Maltsev, AS; Oswald, RE | 1 |
Sakai, R; Swanson, GT | 1 |
Champeil, E; Proni, G; Sapse, D | 1 |
Lash-Van Wyhe, LL; Pentikäinen, OT; Postila, PA; Sakai, R; Sasaki, M; Swanson, GT; Tsubone, K | 1 |
Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M | 1 |
Chamberlain, S; Henley, JM; Jaafari, N; Kantamneni, S; Konopacki, FA; Mellor, JR; Rocca, DL; Rubin, P; Wilkinson, KA | 1 |
Ahmed, AH; Holley, SM; Murthy, SE; Nowak, LM; Oswald, RE; Srinivasan, J; Weiland, GA | 1 |
Ebersole, TL; Mirshahi, T; Mirshahi, UL; Moore, BS | 1 |
Ishikura, T; Maruyama, T; Matsuura, T; Ohbuchi, T; Ohkubo, J; Suzuki, H; Ueta, Y; Yoshimura, M | 1 |
Chebli, M; Eibl, C; Plested, A; Salazar, H | 1 |
Tobi, D | 1 |
4 review(s) available for alanine and kainic acid
Article | Year |
---|---|
The pharmacology of the excitatory neuromuscular junction in the crayfish.
Topics: Alanine; Alkaloids; Animals; Astacoidea; Concanavalin A; Diltiazem; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Histamine H1 Antagonists; Kainic Acid; Neuromuscular Blocking Agents; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Ribonucleotides; Structure-Activity Relationship | 1980 |
Safinamide: from molecular targets to a new anti-Parkinson drug.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbillinae; Humans; Kainic Acid; Levodopa; Mice; MPTP Poisoning; Neurons; Rats; Veratridine | 2006 |
Subtype selective kainic acid receptor agonists: discovery and approaches to rational design.
Topics: Alanine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Kainic Acid; Ligands; Quisqualic Acid; Receptors, Kainic Acid; Rhodophyta; Structure-Activity Relationship | 2009 |
Ligands for ionotropic glutamate receptors.
Topics: Alanine; Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; GluK2 Kainate Receptor; Kainic Acid; Ligands; Mammals; Mollusk Venoms; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 2009 |
48 other study(ies) available for alanine and kainic acid
Article | Year |
---|---|
Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Spinal Nerve Roots | 1979 |
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil | 1992 |
Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons.
Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Aminobutyrates; Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Fura-2; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Phorbol 12,13-Dibutyrate; Phosphoserine; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Type C Phospholipases | 1991 |
Interaction of 5-bromowillardiine with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chickens; Female; Ibotenic Acid; Injections; Kainic Acid; Membrane Potentials; Neuromuscular Depolarizing Agents; Oocytes; Quisqualic Acid; Receptors, Dopamine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1991 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Beta-N-oxalylamino-L-alanine action on glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates | 1989 |
Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Carbachol; Chlorides; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Inositol; Kainic Acid; Kinetics; Lithium; Lithium Chloride; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Electrophysiological studies of kainate, quisqualate, and ibotenate action on the crayfish neuromuscular junction.
Topics: Alanine; Animals; Astacoidea; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neuromuscular Junction; Oxadiazoles; Oxazoles; Picrotoxin; Pyrrolidines; Quisqualic Acid | 1981 |
Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rana temporaria; Rats; Spinal Cord; Synapses | 1981 |
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Crystallography, X-Ray; Dizocilpine Maleate; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Rats; Receptors, AMPA; Stereoisomerism | 1994 |
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil | 1994 |
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis | 1993 |
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Ganglia, Spinal; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neurons; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure.
Topics: Alanine; Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Hepatic Encephalopathy; Hippocampus; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley | 1997 |
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamotrigine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Triazines | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7.
Topics: Alanine; Alternative Splicing; Cell Line; Excitatory Amino Acid Agonists; Genetic Variation; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Humans; Isoxazoles; Kainic Acid; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Propionates; Pyrimidines; Receptors, Kainic Acid; Recombinant Proteins | 1999 |
Role of kynurenines in the neurotoxic actions of kainic acid.
Topics: Alanine; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Interference of S-nitrosoglutathione with the binding of ligands to ionotropic glutamate receptors in pig cerebral cortical synaptic membranes.
Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Kainic Acid; Kinetics; Ligands; Neuroprotective Agents; Nitroso Compounds; Piperazines; Pyrimidinones; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Swine; Synaptic Membranes; Uracil | 2000 |
Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.
Topics: Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Carrier Proteins; Cell Line; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Ganglionic Stimulants; Genistein; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ionophores; Kainic Acid; Protein Isoforms; Protein-Tyrosine Kinases; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Symporters; Telencephalon; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain.
Topics: Acetylcholinesterase; Aging; Alanine; Animals; Autoradiography; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Binding, Competitive; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Solubility; Tritium | 2001 |
Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice.
Topics: Acetylcysteine; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain; Catalase; Cell Death; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Electrons; Excitatory Amino Acid Agonists; Female; Humans; Kainic Acid; Male; Mice; Neurons; Peroxidases; Peroxiredoxins; Polyethylene Glycols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors | 2003 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal; Calcium; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Forelimb; Glycine; Hand Strength; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Psychomotor Performance; Quinoxalines; Receptors, AMPA | 2003 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Drug Resistance; Fetus; Genetic Predisposition to Disease; Glycine; Kainic Acid; Membrane Potentials; Mice; Mice, Transgenic; Motor Neurons; Mutation; Neurotoxins; Protein Subunits; Receptors, AMPA; RNA, Messenger; Superoxide Dismutase; Synaptic Transmission | 2004 |
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Line; Female; Humans; Kainic Acid; Kinetics; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Fibers; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Spinal Nerve Roots | 2004 |
Kainate receptor agonists and antagonists mediate tolerance to kainic acid and reduce high-affinity GTPase activity in young, but not aged, rat hippocampus.
Topics: Action Potentials; Age Factors; Alanine; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GTP Phosphohydrolases; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors.
Topics: Alanine; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Excitatory Amino Acids; Humans; Kainic Acid; Models, Molecular; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate | 2005 |
A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study.
Topics: Alanine; Animals; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Ions; Kainic Acid; Kinetics; Ligands; Models, Biological; Models, Chemical; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, AMPA; RNA, Complementary; Tryptophan; Tyrosine; Xenopus laevis | 2005 |
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Alanine; Animals; Baclofen; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Naphthalenes; Neuromuscular Depolarizing Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Kainic Acid; Receptors, Presynaptic; Thymine | 2006 |
Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding.
Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; GluK2 Kainate Receptor; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Kainic Acid; Kidney; Kinetics; Models, Molecular; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Transfection | 2008 |
Antagonism of recombinant and native GluK3-containing kainate receptors.
Topics: Alanine; Animals; Animals, Newborn; Benzodiazepines; Biophysics; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Protein Subunits; Pyramidal Cells; Receptors, Kainic Acid; Recombinant Proteins; Synaptic Transmission; Thymine; Transfection | 2009 |
Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.
Topics: Alanine; Animals; Crystallography, X-Ray; Glutamic Acid; Kainic Acid; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, AMPA; Solutions; Uracil | 2008 |
Ab initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2 alpha, 3 beta, 4 beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Behavior; Brain; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Molecular Sequence Data; Mutation; Proline; Quantum Theory; Receptors, AMPA; Thermodynamics; Tyrosine | 2009 |
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Humans; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Receptors, Kainic Acid; Structure-Activity Relationship; Time Factors; Transfection; Tritium | 2010 |
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2010 |
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis.
Topics: Alanine; Amino Acid Substitution; Animals; Blotting, Western; Cells, Cultured; Chlorocebus aethiops; COS Cells; Endocytosis; GluK2 Kainate Receptor; HEK293 Cells; Humans; Kainic Acid; Luminescent Proteins; Microscopy, Confocal; Mutation; Neurons; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, Kainic Acid; Serine; SUMO-1 Protein; Sumoylation | 2011 |
The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Amino Acid Substitution; Binding Sites; Cell Line; Crystallography, X-Ray; Glutamic Acid; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kainic Acid; Protein Binding; Protein Conformation; Protein Stability; Protein Structure, Tertiary; Quisqualic Acid; Receptors, AMPA; Static Electricity | 2012 |
A conserved mechanism for gating in an ionotropic glutamate receptor.
Topics: Alanine; Animals; Cell Membrane; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kainic Acid; Ligands; Neurons; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Binding; Protein Structure, Tertiary; Receptors, AMPA; Receptors, Glutamate; Recombinant Proteins; Xenopus laevis | 2013 |
Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Arginine Vasopressin; Cell Separation; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Isoxazoles; Kainic Acid; Luminescent Proteins; Neurons; Oxytocin; Patch-Clamp Techniques; Primary Cell Culture; Propionates; Rats; Rats, Transgenic; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Red Fluorescent Protein; Supraoptic Nucleus; Thymine | 2014 |
Mechanism of partial agonism in AMPA-type glutamate receptors.
Topics: Alanine; Animals; Cross-Linking Reagents; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Kainic Acid; Models, Molecular; Protein Conformation; Protein Domains; Protein Multimerization; Pyrimidines; Rats; Receptors, AMPA; Receptors, Glutamate | 2017 |
Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states revealed by a new dynamics alignment method.
Topics: 2,3-Diphosphoglycerate; Alanine; Algorithms; Allosteric Site; Animals; Binding Sites; Excitatory Amino Acid Agonists; Halogenation; Hemoglobins; Humans; Kainic Acid; Ligands; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Rats; Receptors, AMPA; Sequence Alignment; Sequence Homology, Amino Acid; Thermodynamics; Uracil | 2017 |