alanine and kainic acid

alanine has been researched along with kainic acid in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (13.46)	18.7374
1990's	14 (26.92)	18.2507
2000's	23 (44.23)	29.6817
2010's	8 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Davies, J; Evans, RH; Francis, AA; Watkins, JC	1
Jane, DE; Mayer, ML; Patneau, DK; Watkins, JC	1
Bockaert, J; Do, E; Manzoni, OJ; Poulat, F; Sahuquet, A; Sassetti, I; Sladeczek, FA	1
Bowie, D; Smart, TG	2
Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC	1
Ross, SM; Roy, DN; Spencer, PS	1
Johnson, BG; Schoepp, DD	1
Walker, JB; Woznicki, DT	1
Shinozaki, H	1
Ishida, M; Shinozaki, H	1
Davies, J; Evans, RH; Francis, AA; Jones, AW; Watkins, JC	1
Bregnedal, P; Brehm, L; Bøgesø, KP; Ebert, B; Frederiksen, K; Hansen, JJ; Krogsgaard-Larsen, P; Lenz, S	1
Jane, DE; Mayer, ML; Watkins, JC; Wong, LA	1
Honoré, T; Sheardown, MJ; Suzdak, PD	1
Mayer, ML; Wong, LA	1
Fu, WM; Liou, HC; Yang, RS	1
Butterworth, RF; Michalak, A	1
Fariello, RG; Maj, R; McArthur, RA; Pevarello, P; Salvati, P; Ukmar, G; Varasi, M	1
Banno, T; Kohno, K	1
Cui, C; Mayer, ML	1
Behan, WM; Stone, TW	1
Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F	1
Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V	1
Kimmich, GA; Manglapus, M; Randles, J; Roussie, J	1
Henley, JM; Olivera, S; Rodriguez-Ithurralde, D	1
Clippe, A; Gressens, P; Knoops, B; Plaisant, F; Vander Stricht, D	1
Gouaux, E; Jin, R	1
Callewaert, G; Leyssen, M; Robberecht, W; Van Damme, P; Van Den Bosch, L	1
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA	1
Albo, F; Bernardi, G; Ferrari, F; Longone, P; Mercuri, N; Spalloni, A; Zona, C	1
Alt, AJ; Bleakman, D; Bortolotto, ZA; Buelens, FP; Clarke, VR; Collingridge, GL; Dolman, NP; Jane, DE; Kelland, EE; More, JC; Nistico, R; Ogden, AM; Pilato, F; Troop, HM	1
Hesp, BR; Kerr, DS; Mullaney, I; Wrightson, T	1
Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B	1
Ito, K; Johnson, MS; Pentikäinen, OT; Sakai, R; Sanders, JM; Sasaki, M; Settimo, L; Shoji, M; Swanson, GT	1
Egebjerg, J; Gajhede, M; Geballe, MT; Holm, MM; Kastrup, JS; Naur, P; Traynelis, SF; Vestergaard, B	1
Frerking, M; Partovi, D	1
Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P	1
Bunch, L; Krogsgaard-Larsen, P	1
Green, T; Nayeem, N; Zhang, Y	1
Jane, DE; Mulle, C; Perrais, D; Pinheiro, PS	1
Ahmed, AH; Fenwick, MK; Jane, DE; Maltsev, AS; Oswald, RE	1
Sakai, R; Swanson, GT	1
Champeil, E; Proni, G; Sapse, D	1
Lash-Van Wyhe, LL; Pentikäinen, OT; Postila, PA; Sakai, R; Sasaki, M; Swanson, GT; Tsubone, K	1
Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M	1
Chamberlain, S; Henley, JM; Jaafari, N; Kantamneni, S; Konopacki, FA; Mellor, JR; Rocca, DL; Rubin, P; Wilkinson, KA	1
Ahmed, AH; Holley, SM; Murthy, SE; Nowak, LM; Oswald, RE; Srinivasan, J; Weiland, GA	1
Ebersole, TL; Mirshahi, T; Mirshahi, UL; Moore, BS	1
Ishikura, T; Maruyama, T; Matsuura, T; Ohbuchi, T; Ohkubo, J; Suzuki, H; Ueta, Y; Yoshimura, M	1
Chebli, M; Eibl, C; Plested, A; Salazar, H	1
Tobi, D	1

Reviews

4 review(s) available for alanine and kainic acid

Article	Year
The pharmacology of the excitatory neuromuscular junction in the crayfish. Progress in neurobiology, 1980, Volume: 14, Issue:2-3 Topics: Alanine; Alkaloids; Animals; Astacoidea; Concanavalin A; Diltiazem; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Histamine H1 Antagonists; Kainic Acid; Neuromuscular Blocking Agents; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Ribonucleotides; Structure-Activity Relationship	1980
Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology, 2006, Oct-10, Volume: 67, Issue:7 Suppl 2 Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbillinae; Humans; Kainic Acid; Levodopa; Mice; MPTP Poisoning; Neurons; Rats; Veratridine	2006
Subtype selective kainic acid receptor agonists: discovery and approaches to rational design. Medicinal research reviews, 2009, Volume: 29, Issue:1 Topics: Alanine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Kainic Acid; Ligands; Quisqualic Acid; Receptors, Kainic Acid; Rhodophyta; Structure-Activity Relationship	2009
Ligands for ionotropic glutamate receptors. Progress in molecular and subcellular biology, 2009, Volume: 46 Topics: Alanine; Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; GluK2 Kainate Receptor; Kainic Acid; Ligands; Mammals; Mollusk Venoms; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta	2009

Other Studies

48 other study(ies) available for alanine and kainic acid

Article	Year
Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system. Journal de physiologie, 1979, Volume: 75, Issue:6 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Spinal Nerve Roots	1979
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:2 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Isomerism; Kainic Acid; Kinetics; Mathematics; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Pyrimidinones; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship; Uracil	1992
Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons. European journal of pharmacology, 1991, Jul-12, Volume: 207, Issue:3 Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Aminobutyrates; Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Fura-2; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Phorbol 12,13-Dibutyrate; Phosphoserine; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Type C Phospholipases	1991
Interaction of 5-bromowillardiine with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA. Neuroscience letters, 1991, Jan-02, Volume: 121, Issue:1-2 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chickens; Female; Ibotenic Acid; Injections; Kainic Acid; Membrane Potentials; Neuromuscular Depolarizing Agents; Oocytes; Quisqualic Acid; Receptors, Dopamine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis	1991
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Molecular pharmacology, 1990, Volume: 38, Issue:2 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism	1990
Beta-N-oxalylamino-L-alanine action on glutamate receptors. Journal of neurochemistry, 1989, Volume: 53, Issue:3 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates	1989
Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate. Journal of neurochemistry, 1989, Volume: 53, Issue:6 Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Carbachol; Chlorides; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Inositol; Kainic Acid; Kinetics; Lithium; Lithium Chloride; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains	1989
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids. Journal of neurochemistry, 1988, Volume: 50, Issue:5 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine	1988
Electrophysiological studies of kainate, quisqualate, and ibotenate action on the crayfish neuromuscular junction. Advances in biochemical psychopharmacology, 1981, Volume: 27 Topics: Alanine; Animals; Astacoidea; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neuromuscular Junction; Oxadiazoles; Oxazoles; Picrotoxin; Pyrrolidines; Quisqualic Acid	1981
Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate. Journal of neurochemistry, 1981, Volume: 36, Issue:3 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rana temporaria; Rats; Spinal Cord; Synapses	1981
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA]. Journal of medicinal chemistry, 1994, Apr-01, Volume: 37, Issue:7 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Crystallography, X-Ray; Dizocilpine Maleate; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Rats; Receptors, AMPA; Stereoisomerism	1994
Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:6 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Ganglia, Spinal; Hippocampus; Kainic Acid; Kinetics; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Uracil	1994
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX). European journal of pharmacology, 1993, May-15, Volume: 245, Issue:3 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella	1993
Thiocyanate ions selectively antagonize AMPA-evoked responses in Xenopus laevis oocytes microinjected with rat brain mRNA. British journal of pharmacology, 1993, Volume: 109, Issue:3 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Cell Membrane; Cerebellum; Electrophysiology; Female; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Microinjections; Neurons; Oocytes; Pregnancy; Pyrimidinones; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thiocyanates; Uracil; Xenopus laevis	1993
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. Molecular pharmacology, 1993, Volume: 44, Issue:3 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Ganglia, Spinal; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neurons; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid	1993
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles. Neuroscience, 1996, Volume: 75, Issue:1 Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis	1996
Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure. Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:3 Topics: Alanine; Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Hepatic Encephalopathy; Hippocampus; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley	1997
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat. European journal of pharmacology, 1998, Oct-16, Volume: 359, Issue:1 Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamotrigine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Triazines	1998
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells. The Journal of comparative neurology, 1998, Dec-14, Volume: 402, Issue:2 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration	1998
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Oct-01, Volume: 19, Issue:19 Topics: Alanine; Alternative Splicing; Cell Line; Excitatory Amino Acid Agonists; Genetic Variation; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Humans; Isoxazoles; Kainic Acid; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Propionates; Pyrimidines; Receptors, Kainic Acid; Recombinant Proteins	1999
Role of kynurenines in the neurotoxic actions of kainic acid. British journal of pharmacology, 2000, Volume: 129, Issue:8 Topics: Alanine; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2000
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain. Neurochemistry international, 2001, Volume: 38, Issue:1 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles	2001
Interference of S-nitrosoglutathione with the binding of ligands to ionotropic glutamate receptors in pig cerebral cortical synaptic membranes. Neurochemical research, 2000, Volume: 25, Issue:8 Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Kainic Acid; Kinetics; Ligands; Neuroprotective Agents; Nitroso Compounds; Piperazines; Pyrimidinones; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Swine; Synaptic Membranes; Uracil	2000
Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1. The Journal of membrane biology, 2001, Jul-01, Volume: 182, Issue:1 Topics: Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Carrier Proteins; Cell Line; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Ganglionic Stimulants; Genistein; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ionophores; Kainic Acid; Protein Isoforms; Protein-Tyrosine Kinases; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Symporters; Telencephalon; Tetradecanoylphorbol Acetate; Time Factors	2001
Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology, 2001, Volume: 133, Issue:7 Topics: Acetylcholinesterase; Aging; Alanine; Animals; Autoradiography; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Binding, Competitive; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Solubility; Tritium	2001
Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice. Free radical biology & medicine, 2003, Apr-01, Volume: 34, Issue:7 Topics: Acetylcysteine; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain; Catalase; Cell Death; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Electrons; Excitatory Amino Acid Agonists; Female; Humans; Kainic Acid; Male; Mice; Neurons; Peroxidases; Peroxiredoxins; Polyethylene Glycols; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors	2003
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry, 2003, May-13, Volume: 42, Issue:18 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil	2003
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. Neuroscience letters, 2003, Jun-05, Volume: 343, Issue:2 Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal; Calcium; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Forelimb; Glycine; Hand Strength; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Psychomotor Performance; Quinoxalines; Receptors, AMPA	2003
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6 Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil	2003
Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture. Neurobiology of disease, 2004, Volume: 15, Issue:2 Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Drug Resistance; Fetus; Genetic Predisposition to Disease; Glycine; Kainic Acid; Membrane Potentials; Mice; Mice, Transgenic; Motor Neurons; Mutation; Neurotoxins; Protein Subunits; Receptors, AMPA; RNA, Messenger; Superoxide Dismutase; Synaptic Transmission	2004
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology, 2004, Volume: 47, Issue:1 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Line; Female; Humans; Kainic Acid; Kinetics; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Fibers; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Spinal Nerve Roots	2004
Kainate receptor agonists and antagonists mediate tolerance to kainic acid and reduce high-affinity GTPase activity in young, but not aged, rat hippocampus. Journal of neurochemistry, 2004, Volume: 90, Issue:1 Topics: Action Potentials; Age Factors; Alanine; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GTP Phosphohydrolases; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid	2004
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium	2004
Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3 Topics: Alanine; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Excitatory Amino Acids; Humans; Kainic Acid; Models, Molecular; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate	2005
A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study. The Journal of biological chemistry, 2005, Oct-21, Volume: 280, Issue:42 Topics: Alanine; Animals; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Ions; Kainic Acid; Kinetics; Ligands; Models, Biological; Models, Chemical; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, AMPA; RNA, Complementary; Tryptophan; Tyrosine; Xenopus laevis	2005
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors. Neuropharmacology, 2006, Volume: 51, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Alanine; Animals; Baclofen; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Naphthalenes; Neuromuscular Depolarizing Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Kainic Acid; Receptors, Presynaptic; Thymine	2006
Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding. Molecular pharmacology, 2008, Volume: 74, Issue:4 Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; GluK2 Kainate Receptor; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Kainic Acid; Kidney; Kinetics; Models, Molecular; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Transfection	2008
Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology, 2009, Volume: 56, Issue:1 Topics: Alanine; Animals; Animals, Newborn; Benzodiazepines; Biophysics; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Protein Subunits; Pyramidal Cells; Receptors, Kainic Acid; Recombinant Proteins; Synaptic Transmission; Thymine; Transfection	2009
Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution. Biochemistry, 2008, Oct-07, Volume: 47, Issue:40 Topics: Alanine; Animals; Crystallography, X-Ray; Glutamic Acid; Kainic Acid; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, AMPA; Solutions; Uracil	2008
Ab initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2 alpha, 3 beta, 4 beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Journal of molecular modeling, 2009, Volume: 15, Issue:9 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Behavior; Brain; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Molecular Sequence Data; Mutation; Proline; Quantum Theory; Receptors, AMPA; Thermodynamics; Tyrosine	2009
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine. Neuropharmacology, 2010, Volume: 58, Issue:3 Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Humans; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Receptors, Kainic Acid; Structure-Activity Relationship; Time Factors; Transfection; Tritium	2010
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells. Neurochemistry international, 2010, Volume: 56, Issue:5 Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles	2010
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49 Topics: Alanine; Amino Acid Substitution; Animals; Blotting, Western; Cells, Cultured; Chlorocebus aethiops; COS Cells; Endocytosis; GluK2 Kainate Receptor; HEK293 Cells; Humans; Kainic Acid; Luminescent Proteins; Microscopy, Confocal; Mutation; Neurons; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, Kainic Acid; Serine; SUMO-1 Protein; Sumoylation	2011
The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 2012, May-15, Volume: 51, Issue:19 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Amino Acid Substitution; Binding Sites; Cell Line; Crystallography, X-Ray; Glutamic Acid; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kainic Acid; Protein Binding; Protein Conformation; Protein Stability; Protein Structure, Tertiary; Quisqualic Acid; Receptors, AMPA; Static Electricity	2012
A conserved mechanism for gating in an ionotropic glutamate receptor. The Journal of biological chemistry, 2013, Jun-28, Volume: 288, Issue:26 Topics: Alanine; Animals; Cell Membrane; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kainic Acid; Ligands; Neurons; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Binding; Protein Structure, Tertiary; Receptors, AMPA; Receptors, Glutamate; Recombinant Proteins; Xenopus laevis	2013
Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats. Journal of neuroendocrinology, 2014, Volume: 26, Issue:1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Arginine Vasopressin; Cell Separation; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Isoxazoles; Kainic Acid; Luminescent Proteins; Neurons; Oxytocin; Patch-Clamp Techniques; Primary Cell Culture; Propionates; Rats; Rats, Transgenic; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Red Fluorescent Protein; Supraoptic Nucleus; Thymine	2014
Mechanism of partial agonism in AMPA-type glutamate receptors. Nature communications, 2017, 02-17, Volume: 8 Topics: Alanine; Animals; Cross-Linking Reagents; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Kainic Acid; Models, Molecular; Protein Conformation; Protein Domains; Protein Multimerization; Pyrimidines; Rats; Receptors, AMPA; Receptors, Glutamate	2017
Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states revealed by a new dynamics alignment method. Proteins, 2017, Volume: 85, Issue:8 Topics: 2,3-Diphosphoglycerate; Alanine; Algorithms; Allosteric Site; Animals; Binding Sites; Excitatory Amino Acid Agonists; Halogenation; Hemoglobins; Humans; Kainic Acid; Ligands; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Rats; Receptors, AMPA; Sequence Alignment; Sequence Homology, Amino Acid; Thermodynamics; Uracil	2017