alanine has been researched along with isoxazoles in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.20) | 18.7374 |
| 1990's | 14 (34.15) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Doolabh, K; Mann, GE; Sastre, J; Sweiry, JH; Viña, J | 1 |
| Ikegami, F; Ishikawa, T; Itagaki, S; Kuo, YH; Lambein, F; Murakoshi, I; Ongena, G | 1 |
| Davies, KP; Köhler, P | 1 |
| Cole, LA; Sahai, A; Tannen, RL | 1 |
| Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE | 1 |
| Sastrasinh, M; Sastrasinh, S | 1 |
| Kobayashi, K; Smith, JA | 1 |
| Esposito, AL; Pennington, JE | 1 |
| Bregnedal, P; Brehm, L; Bøgesø, KP; Ebert, B; Frederiksen, K; Hansen, JJ; Krogsgaard-Larsen, P; Lenz, S | 1 |
| Ebert, B; Krogsgaard-Larsen, P; Lenz, SM; Lund, TM; Madsen, U | 1 |
| Ahmed, N; Weidemann, MJ | 1 |
| Allen, CN; Lambein, F; Ludolph, AC; Riepe, M; Spencer, PS | 1 |
| Fujii, J; Ikeda, Y; Meister, A; Smith, TK; Taniguchi, N | 1 |
| Ebert, B; Krogsgaard-Larsen, P; Madsen, U; Søby, KK | 1 |
| Ikegami, F; Kamiya, M; Kuo, YH; Lambein, F; Murakoshi, I | 1 |
| Ebert, B; Falch, E; Johansen, TN; Krogsgaard-Larsen, P | 1 |
| Ikegami, F; Kusama, T; Kusama-Eguchi, K; Lambein, F; Watanabe, K | 1 |
| Bräuner-Osborne, H; Brehm, L; Christensen, IT; Didriksen, M; Ebert, B; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U; Søby, KK | 1 |
| Cui, C; Mayer, ML | 1 |
| Forsythe, MS; Khurana, S; Mousa, SA | 1 |
| Bozarth, JM; Forsythe, MS; Mousa, SA; Slee, A | 1 |
| Hollis, GF; Wynn, R; Zolotarjova, NI | 1 |
| Bräüner-Osborne, H; Frydenvang, K; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U; Nielsen, B; Sløk, FA; Stensbøl, TB; Vogensen, SB | 1 |
| Abulencia, JP; Konstantopoulos, K; McCarty, OJ; Mousa, SA; Turner, NA | 1 |
| Feuerstein, GZ; Wang, X; Zondlo, SC | 1 |
| Hiratake, J; Inoue, M; Sakata, K | 1 |
| Barbera, FA; Dorsam, RT; Feuerstein, GZ; Friedman, SM; Gibbs, S; Lauver, A; Savion, N; Varon, D; Wang, H; Wang, X | 1 |
| Billheimer, JT; He, B; Seiffert, D; Spitz, SM; Stern, AM | 1 |
| Billheimer, JT; He, B; Kieras, CJ; Pedicord, DL; Seiffert, D; Stern, AM | 1 |
| Bräuner-Osborne, H; Brehm, L; Egebjerg, J; Greenwood, JR; Hansen, KB; Krogsgaard-Larsen, P; Kronborg, TT; Nielsen, B; Sløk, FA; Stensbøl, TB | 1 |
| Brehm, L; Gajhede, M; Greenwood, JR; Kastrup, JS; Nielsen, BB; Pickering, DS; Schousboe, A | 1 |
| Berlinck, RG; de Oliveira, MF; König, GM; Molinski, TF; Rogers, EW | 1 |
| Connor, JH; Connor, RF; Hantgan, RR; Mousa, SA; Stahle, MC | 1 |
| Haque, RM; Hussain, M; Kuo, YH; Lambein, F | 1 |
| Duncan, GE; Koller, BH; Moy, SS | 1 |
| Badawy, SI; LaMarche, K; Narang, AS; Subramanian, G; Varia, SA | 1 |
| Ishikura, T; Maruyama, T; Matsuura, T; Ohbuchi, T; Ohkubo, J; Suzuki, H; Ueta, Y; Yoshimura, M | 1 |
| Al-Musaed, A; Clausen, RP; Frydenvang, K; Jensen, AA; Kastrup, JS; Larsen, Y; Navarrete, CV; Nielsen, B; Pickering, DS; Wang, SY | 1 |
| Alt, J; Ator, NA; DeVivo, M; Hin, N; Popiolek, M; Rais, R; Rojas, C; Slusher, BS; Tsukamoto, T; Wilmoth, H | 1 |
| Brindisi, M; Ghosh, AK; Ghosh, K; Huang, X; Kumaragurubaran, N; Lendy, EK; Mesecar, AD; Tang, J; Yen, YC | 1 |
| de Carvalho, LPS; de Chiara, C; Douglas, HL; Garza-Garcia, A; Homšak, M; Kelly, G; Prosser, GA; Purkiss, AG; Tate, EW | 1 |
41 other study(ies) available for alanine and isoxazoles
| Article | Year |
|---|---|
Significance of gamma-glutamyltranspeptidase in exocrine pancreatic amino acid transport.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Epithelium; gamma-Glutamyltransferase; Glutamine; Indicator Dilution Techniques; Isoxazoles; Male; Pancreas; Rats; Rats, Inbred Strains | 1991 |
Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid.
Topics: Alanine; Amino Acids, Diamino; Fabaceae; Isoxazoles; Neurotoxins; Plants, Medicinal | 1991 |
The role of amino acids in the energy generating pathways of Litomosoides carinii.
Topics: Acetates; Alanine; Ammonia; Animals; Antimetabolites; Carbon Dioxide; Energy Metabolism; Female; Filarioidea; Glucose; Glutamine; Isoxazoles; Lactates; Lactic Acid; Rats | 1990 |
Pathways and regulation of ammoniagenesis by the LLC-PK1 cells in culture.
Topics: Alanine; Aminooxyacetic Acid; Ammonia; Animals; Antimetabolites; Cell Line; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Isoxazoles; Ketoglutaric Acids; Kidney; Kinetics; Mitochondria; Models, Biological | 1989 |
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine | 1988 |
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats | 1988 |
Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction.
Topics: Affinity Labels; Alanine; Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Aminopeptidases; Animals; Diethyl Pyrocarbonate; Hydrogen-Ion Concentration; Isoflurophate; Isoxazoles; Kinetics; Liver; Mathematics; Melanocyte-Stimulating Hormones; Peptide Hydrolases; Rats; Renin; Sodium Chloride; Sodium Cyanide; Substrate Specificity; Zinc | 1987 |
Experimental pneumonia due to Haemophilus influenzae: observations on pathogenesis and treatment.
Topics: Alanine; Ampicillin; Animals; Anti-Bacterial Agents; Cefamandole; Chloramphenicol; Drug Combinations; Drug Evaluation, Preclinical; Erythromycin; Female; Haemophilus Infections; Haemophilus influenzae; Isoxazoles; Lung; Mice; Mice, Inbred C57BL; Pneumonia; Sulfisoxazole | 1984 |
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Crystallography, X-Ray; Dizocilpine Maleate; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Rats; Receptors, AMPA; Stereoisomerism | 1994 |
Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Membrane; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Isoxazoles; Male; Organ Specificity; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Structure-Activity Relationship | 1994 |
Biochemical effect of three different inhibitors of purine/pyrimidine metabolism on differentiation in HL60 cells.
Topics: Alanine; Cell Differentiation; Cell Division; Formates; Hematopoiesis; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine Monophosphate; Isoxazoles; Leukemia, Myeloid; Mycophenolic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Reactive Oxygen Species; Tumor Cells, Cultured | 1995 |
In vitro toxicological investigations of isoxazolinone amino acids of Lathyrus sativus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Aminobutyrates; Animals; Electrophysiology; Hippocampus; Isoxazoles; Lathyrism; Mice; Motor Cortex; Nerve Degeneration; Plants, Toxic | 1995 |
Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidases.
Topics: Alanine; Amino Acid Sequence; Animals; Antimetabolites; Base Sequence; Binding Sites; Cloning, Molecular; DNA Primers; gamma-Glutamyltransferase; Humans; Hydroxylamine; Hydroxylamines; Isoxazoles; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Point Mutation; Rats; Recombinant Proteins; Restriction Mapping; Serine; Swine; Threonine | 1995 |
Functional partial agonism at ionotropic excitatory amino acid receptors.
Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Dinucleoside Phosphates; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Models, Neurological; N-Methylaspartate; Propionates; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate | 1996 |
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
Topics: Alanine; Chemical Phenomena; Chemistry, Physical; Cysteine Synthase; Fabaceae; Hydrogen-Ion Concentration; Isomerism; Isoxazoles; Kinetics; Plants, Medicinal; Spectrophotometry, Ultraviolet | 1996 |
AMPA receptor agonists: resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-isoxazol-4-yl]-propionic acid (2-Py-AMPA).
Topics: Alanine; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Circular Dichroism; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyridines; Radioligand Assay; Rats; Receptors, AMPA; Spectrophotometry, Ultraviolet; Stereoisomerism | 1997 |
Inhibitory activity of a naturally occurring heterocyclic beta-substituted alanine, beta-(isoxazolin-5-on-4-yl)-L-alanine, on the L-glutamate/L-aspartate transporter (GLAST) expressed in Xenopus oocytes.
Topics: Alanine; Amino Acid Transport System X-AG; Animals; Antifungal Agents; ATP-Binding Cassette Transporters; Biological Transport; Isoxazoles; Oocytes; Patch-Clamp Techniques; Xenopus laevis | 1997 |
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Topics: Alanine; Animals; Anticonvulsants; Brain; Calcium Chloride; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Crystallography, X-Ray; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoxazoles; Male; Mice; Molecular Conformation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6, and GluR7.
Topics: Alanine; Alternative Splicing; Cell Line; Excitatory Amino Acid Agonists; Genetic Variation; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Humans; Isoxazoles; Kainic Acid; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Propionates; Pyrimidines; Receptors, Kainic Acid; Recombinant Proteins | 1999 |
Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists.
Topics: Abciximab; Alanine; Amidines; Antibodies, Monoclonal; Blood Coagulation; Blood Platelets; Elasticity; Fibrin; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Nephelometry and Turbidimetry; Oxazoles; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Sulfonamides; Thrombelastography; Thromboplastin; Viscosity | 2000 |
Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: role of plasma calcium levels.
Topics: Abciximab; Alanine; Amidines; Analysis of Variance; Antibodies, Monoclonal; Anticoagulants; Blood Platelets; Calcium; Citric Acid; Eptifibatide; Fibrinogen; Heparin; Humans; Immunoglobulin Fab Fragments; Iodine Radioisotopes; Isoxazoles; Peptides; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Pyrrolidines; Tirofiban; Tyrosine | 2000 |
Unusually stable and long-lived ligand-induced conformations of integrins.
Topics: Alanine; Binding Sites; Blood Platelets; Humans; Isoxazoles; Kinetics; Ligands; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Receptors, Vitronectin; Sodium Dodecyl Sulfate; Time Factors | 2001 |
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
Topics: Alanine; Animals; CHO Cells; Chromatography, High Pressure Liquid; Cloning, Molecular; Cricetinae; Crystallography, X-Ray; Electrophysiology; Excitatory Amino Acid Agonists; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Models, Molecular; Protein Conformation; Rats; Receptors, Glutamate; Second Messenger Systems; Stereoisomerism | 2001 |
Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis.
Topics: Alanine; Amidines; Blood Platelets; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Isoxazoles; Models, Biological; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Thrombosis | 2002 |
Effects of orally active glycoprotein IIb/IIIa antagonists on platelet CD40 ligand (CD154) expression and platelet-heteroaggregate formation.
Topics: Administration, Oral; Alanine; Amidines; CD40 Ligand; Cell Adhesion; Dose-Response Relationship, Drug; Humans; Isoxazoles; Leukocytes; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proteins; Pyrrolidines; Receptors, Thrombin | 2002 |
gamma-Glutamyltranspeptidase and gamma-glutamyl peptide ligases: fluorophosphonate and phosphonodifluoromethyl ketone analogs as probes of tetrahedral transition state and gamma-glutamyl-phosphate intermediate.
Topics: Adenosine Triphosphate; Affinity Labels; Alanine; Aminobutyrates; Animals; Chromatography, High Pressure Liquid; Diazooxonorleucine; Enzyme Inhibitors; Escherichia coli Proteins; Fluorescent Dyes; Fluorides; gamma-Glutamyltransferase; Humans; Isoxazoles; Kidney; Ligases; Molecular Structure; Phosphates; Spectrometry, Mass, Electrospray Ionization | 2002 |
Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion.
Topics: Abciximab; Alanine; Amidines; Analysis of Variance; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cell Aggregation; Dose-Response Relationship, Drug; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Peptides; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Rheology; Shear Strength; Temperature; Tirofiban; Tyrosine | 2002 |
Effects of glycoprotein IIb/IIIa antagonists on platelet activation: development of a transfer method to mimic peak to trough receptor occupancy.
Topics: Alanine; Amidines; Benzodiazepines; Blood Platelets; Humans; In Vitro Techniques; Isoxazoles; Oximes; P-Selectin; Piperidines; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Thrombosis | 2002 |
Regulation of clot retraction by glycoprotein IIb/IIIa antagonists.
Topics: Abciximab; Alanine; Amidines; Antibodies, Monoclonal; Blood Platelets; Clot Retraction; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Isoxazoles; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Sulfonamides; Tyrosine | 2002 |
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.
Topics: Alanine; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Monte Carlo Method; Oocytes; Patch-Clamp Techniques; Propionates; Radioligand Assay; Receptors, Kainic Acid; Sequence Homology, Amino Acid; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2003 |
Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.
Topics: Alanine; Animals; Cells, Cultured; Female; Isoxazoles; Ligands; Receptors, AMPA; Spodoptera; Xenopus laevis | 2005 |
Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis.
Topics: Alanine; Animals; Australia; Brazil; Dinitrobenzenes; Florida; Isoxazoles; Mixed Function Oxygenases; Molecular Structure; Porifera; Stereoisomerism; Tyrosine | 2005 |
AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists.
Topics: Administration, Oral; Alanine; Amidines; Binding, Competitive; Blood Platelets; Dimerization; Dose-Response Relationship, Drug; Eptifibatide; Female; Fibrinogen; Humans; In Vitro Techniques; Injections, Intravenous; Intercellular Signaling Peptides and Proteins; Isoxazoles; Kinetics; Male; Models, Molecular; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Pyrrolidines; Reference Values; Structure-Activity Relationship; Tirofiban; Tyrosine | 2007 |
Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid β-ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid) in callus tissue of Lathyrus sativus.
Topics: Alanine; Amino Acids, Diamino; Excitatory Amino Acids; Isoxazoles; Lathyrism; Lathyrus; Micronutrients; Neurotoxins; Salinity; Tissue Culture Techniques | 2011 |
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.
Topics: Alanine; Animals; Antipsychotic Agents; Carrier Proteins; Disease Models, Animal; Gene Knockdown Techniques; Isoxazoles; Mice; Nerve Tissue Proteins; Propionates; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Uracil | 2012 |
Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation.
Topics: Alanine; Drug Compounding; Isoxazoles; Particle Size; Porosity; Powders; Pyrazoles; Quality Control; Solubility; Tablets; Technology, Pharmaceutical; Triazines; Water | 2012 |
Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Arginine Vasopressin; Cell Separation; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Isoxazoles; Kainic Acid; Luminescent Proteins; Neurons; Oxytocin; Patch-Clamp Techniques; Primary Cell Culture; Propionates; Rats; Rats, Transgenic; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Red Fluorescent Protein; Supraoptic Nucleus; Thymine | 2014 |
Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues.
Topics: Alanine; Animals; Brain; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Rats; Receptors, AMPA; Structure-Activity Relationship | 2016 |
Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect.
Topics: Administration, Oral; Alanine; Animals; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoxazoles; Male; Papio; Receptors, N-Methyl-D-Aspartate; Species Specificity | 2016 |
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Topics: Alanine; Amides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Bridged Bicyclo Compounds; Carboxylic Acids; Catalytic Domain; Crystallography, X-Ray; Cysteine; Humans; Isoxazoles; Molecular Structure; Protease Inhibitors | 2018 |
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
Topics: Alanine; Alanine Racemase; Amino Acid Sequence; Antibiotics, Antitubercular; Bacterial Proteins; Binding Sites; Cycloserine; Escherichia coli; Isoxazoles; Ligases; Mycobacterium tuberculosis; Oximes; Protein Binding; Protein Conformation; Recombinant Proteins | 2020 |