alanine has been researched along with hirudin in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dodt, J; Köhler, S; Schmitz, T; Wilhelm, B | 1 |
| Broersma, RJ; Burkhart, JP; Kutcher, LW; Malikayil, JA; Mehdi, S; Neises, B; Peet, NP; Schatzman, GL; Schreuder, HA; Tardif, C | 1 |
| Bode, W; Brandstetter, H; Chang, J; Hamaguchi, N; Jin, J; Lollar, P; Stafford, DW; Straight, DL | 1 |
| De Filippis, V; Di Cera, E; Fontana, A; Quarzago, D; Vindigni, A | 1 |
| Bauman, SJ; Church, FC | 1 |
| Krishnan, R; Sadler, JE; Tulinsky, A | 1 |
6 other study(ies) available for alanine and hirudin
| Article | Year |
|---|---|
Distinct binding sites of Ala48-hirudin1-47 and Ala48-hirudin48-65 on alpha-thrombin.
Topics: Alanine; Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hirudins; Humans; Molecular Sequence Data; Mutation; Proline; Thrombin | 1990 |
Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Topics: Alanine; Animals; Binding Sites; Crystallography, X-Ray; Drug Design; Hirudins; Models, Molecular; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Protein Conformation; Rats; Serine Proteinase Inhibitors; Software; Thrombin; Trypsin; Trypsin Inhibitors; Tryptophan | 1997 |
Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity.
Topics: Alanine; Amino Acid Substitution; Arginine; Catalysis; Electrophoresis, Polyacrylamide Gel; Factor IX; Factor VIIIa; Heparin; Hirudins; Humans; Protein Binding; Recombinant Proteins | 1998 |
Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cattle; Circular Dichroism; Glycine; Hirudins; Humans; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Serine; Spectrometry, Fluorescence; Thrombin; Tyrosine; Valine | 1998 |
Enhancement of heparin cofactor II anticoagulant activity.
Topics: Alanine; Anticoagulants; Antithrombin III; Antithrombin III Deficiency; Antithrombins; Carboxypeptidases; Carboxypeptidases A; Dermatan Sulfate; Factor Xa Inhibitors; Glycosaminoglycans; Heparin; Heparin Cofactor II; Hirudins; Humans; Kinetics; Lysine; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Recombinant Proteins; Sepharose; Serine Proteinase Inhibitors; Thrombin | 1999 |
Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Crystallography, X-Ray; Fibrinopeptide A; Hirudins; Humans; Models, Molecular; Peptide Fragments; Point Mutation; Protein Conformation; Serine; Software; Thrombin | 2000 |