alanine and hirudin

alanine has been researched along with hirudin in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dodt, J; Köhler, S; Schmitz, T; Wilhelm, B1
Broersma, RJ; Burkhart, JP; Kutcher, LW; Malikayil, JA; Mehdi, S; Neises, B; Peet, NP; Schatzman, GL; Schreuder, HA; Tardif, C1
Bode, W; Brandstetter, H; Chang, J; Hamaguchi, N; Jin, J; Lollar, P; Stafford, DW; Straight, DL1
De Filippis, V; Di Cera, E; Fontana, A; Quarzago, D; Vindigni, A1
Bauman, SJ; Church, FC1
Krishnan, R; Sadler, JE; Tulinsky, A1

Other Studies

6 other study(ies) available for alanine and hirudin

ArticleYear
Distinct binding sites of Ala48-hirudin1-47 and Ala48-hirudin48-65 on alpha-thrombin.
    The Journal of biological chemistry, 1990, Jan-15, Volume: 265, Issue:2

    Topics: Alanine; Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hirudins; Humans; Molecular Sequence Data; Mutation; Proline; Thrombin

1990
Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Biochemistry, 1997, Feb-04, Volume: 36, Issue:5

    Topics: Alanine; Animals; Binding Sites; Crystallography, X-Ray; Drug Design; Hirudins; Models, Molecular; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Protein Conformation; Rats; Serine Proteinase Inhibitors; Software; Thrombin; Trypsin; Trypsin Inhibitors; Tryptophan

1997
Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity.
    The Journal of biological chemistry, 1998, May-15, Volume: 273, Issue:20

    Topics: Alanine; Amino Acid Substitution; Arginine; Catalysis; Electrophoresis, Polyacrylamide Gel; Factor IX; Factor VIIIa; Heparin; Hirudins; Humans; Protein Binding; Recombinant Proteins

1998
Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
    Biochemistry, 1998, Sep-29, Volume: 37, Issue:39

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cattle; Circular Dichroism; Glycine; Hirudins; Humans; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Serine; Spectrometry, Fluorescence; Thrombin; Tyrosine; Valine

1998
Enhancement of heparin cofactor II anticoagulant activity.
    The Journal of biological chemistry, 1999, Dec-03, Volume: 274, Issue:49

    Topics: Alanine; Anticoagulants; Antithrombin III; Antithrombin III Deficiency; Antithrombins; Carboxypeptidases; Carboxypeptidases A; Dermatan Sulfate; Factor Xa Inhibitors; Glycosaminoglycans; Heparin; Heparin Cofactor II; Hirudins; Humans; Kinetics; Lysine; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Recombinant Proteins; Sepharose; Serine Proteinase Inhibitors; Thrombin

1999
Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.
    Acta crystallographica. Section D, Biological crystallography, 2000, Volume: 56, Issue:Pt 4

    Topics: Alanine; Amino Acid Substitution; Binding Sites; Crystallography, X-Ray; Fibrinopeptide A; Hirudins; Humans; Models, Molecular; Peptide Fragments; Point Mutation; Protein Conformation; Serine; Software; Thrombin

2000