alanine has been researched along with guanosine triphosphate in 48 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (14.58) | 18.7374 |
1990's | 16 (33.33) | 18.2507 |
2000's | 21 (43.75) | 29.6817 |
2010's | 3 (6.25) | 24.3611 |
2020's | 1 (2.08) | 2.80 |
Authors | Studies |
---|---|
Irving, MG; Williams, JF | 2 |
Kawakami, M; Takemura, S; Tanada, S | 1 |
Kyprianou, N; Taylor-Papadimitriou, J | 1 |
Bartfai, T; Iverfeldt, K; Ogren, SO | 1 |
Gupta, SL; Lengyel, P; Sopori, ML; Waterson, J | 1 |
Golini, F; Thach, RE | 1 |
Marcus, A; Seal, SN | 1 |
Meredith, M; Metz, S; Rabaglia, M | 1 |
Bocchini, V; Krab, IM; Parmeggiani, A; Scarano, G | 1 |
Lee, YH; Lin, K; Okar, D; Pilkis, SJ | 1 |
Castle, D; Dent, P; Romero, G; Sturgill, TW; Vincent, LA; Wu, J | 1 |
Boekhoff, I; Breer, H; Restrepo, D | 1 |
Coley, C; Daniell, S; Naylor, LH; Strange, PG; Woodward, R | 1 |
Ahmadian, MR; Blechschmidt, B; Kreutzer, R; Sprinzl, M | 1 |
Cerione, RA; Erickson, JW; Mittal, R | 1 |
Hwang, MC; Hwang, YW; Sung, YJ | 1 |
Cheng, E; Cline, RT; Fraser, CM; Geoghagen, NS; Lee, NH | 1 |
Hoshino, S; Kanaho, Y; Katada, T; Kukimoto, I; Maehama, T; Nimota, K; Nishina, H; Takahashi, K | 1 |
Berghuis, AM; Gilman, AG; Lee, E; Raw, AS; Sprang, SR | 1 |
Dev, KK; Henley, JM; Roberts, PJ | 1 |
Finken-Eigen, M; Köhrer, K; Müller, S | 1 |
Liu, X; Malbon, CC; Wang, HY | 1 |
Das, S; Maitra, U | 1 |
Dagher, PC | 1 |
Brannetti, B; Ferrè, F; Helmer-Citterich, M; Valencia, A; Via, A | 1 |
Buckingham, R; Dinçbas-Renqvist, V; Ehrenberg, M; Engström, A; Heurgué-Hamard, V; Mora, L | 1 |
Bhatt, A; Lin, B; Maddock, JR; Pawloski, L; Pfeffer, SM; Skidmore, JM | 1 |
Pleiss, JA; Uhlenbeck, OC | 1 |
Gudkov, AT; Liljas, A; Martemyanov, KA; Yarunin, AS | 1 |
Barends, S; Karzai, AW; Kraal, B; Sauer, RT; Wower, J | 1 |
Brieba, LG; Padilla, R; Sousa, R | 1 |
Bearne, SL; Iyengar, A | 1 |
Frank, J; Gillet, R; Henne, A; Kaur, S; Ramakrishnan, V; Valle, M | 1 |
Bae, YS; Kim, YS; Lee, JY; Park, W; Son, MY | 1 |
Krishnamurthy, G; Smith, D; Tawa, G; Wang, Y; Young, KH | 1 |
Alves, I; Cowell, S; Davis, P; Hruby, VJ; Lee, YS; Porreca, F; Tang, X | 1 |
Leonard, M; Schmid, SL; Song, BD | 1 |
Fekete, CA; Hinnebusch, AG; Nielsen, KH; Valásek, L; Zhang, F | 1 |
Bar-Sagi, D; Boykevisch, S; Ford, B; Nassar, N; Skowronek, K | 1 |
Buschauer, A; Dove, S; Ghorai, P; Kraus, A; Preuss, H; Seifert, R | 1 |
Marco-Marín, C; Rubio, V | 1 |
Ledoux, S; Olejniczak, M; Uhlenbeck, OC | 1 |
Homma, M; Kojima, S; Kusumoto, A; Nishioka, N | 1 |
Gambaryan, S; Sickmann, A; Subramanian, H; Walter, U; Zahedi, RP | 1 |
Proud, CG; Stead, RL | 1 |
Ho, J; Ikura, M; Ishiyama, N; Marshall, CB; Mazhab-Jafari, MT; Stambolic, V | 1 |
Elfiky, AA | 1 |
48 other study(ies) available for alanine and guanosine triphosphate
Article | Year |
---|---|
Class experiment: Kinetic studies on the regulation of rabbit liver pyruvate kinase.
Topics: Adenosine Diphosphate; Alanine; Allosteric Regulation; Animals; Chromatography, DEAE-Cellulose; Enzyme Activation; Female; Fructosephosphates; Guanosine Triphosphate; Hexosediphosphates; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Liver; Magnesium; Mathematics; Pyruvate Kinase; Rabbits | 1975 |
Properties of alanyl-oligonucleotide, puromycin, and Staphylococcus epidermidis glycyl-tRNA in interaction with elongation factor Tu:GTP complex.
Topics: Alanine; Binding Sites; Candida; Chromatography, Gel; Glycine; Guanosine Triphosphate; Peptide Elongation Factors; Protein Binding; Puromycin; RNA, Bacterial; RNA, Transfer; Staphylococcus | 1975 |
Isolation of azatyrosine-induced revertants from ras-transformed human mammary epithelial cells.
Topics: Alanine; Animals; Blotting, Northern; Breast; Cell Division; Cell Transformation, Viral; Cells, Cultured; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Mice; Mice, Nude; Oncogene Protein p21(ras); RNA, Messenger | 1992 |
Substance P receptors in the rat spinal cord: the effect of GTP and of chronic antidepressant treatment.
Topics: Alanine; Animals; Antidepressive Agents; Guanosine Triphosphate; Imipramine; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Zimeldine | 1988 |
Apparent changes in ribosome conformation during protein synthesis. Centrifugation at high speed distorts initiation, pretranslocaton, and posttranslocation complexes to a different extent.
Topics: Alanine; Bacillus; Bacterial Proteins; Bacteriophages; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography, Gel; Escherichia coli; Formates; Fusidic Acid; Guanosine Triphosphate; Methionine; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Puromycin; Ribosomes; RNA, Transfer; RNA, Viral; Thyrotropin; Tritium | 1972 |
An investigation of the decoding of triplets adjacent to AUG during initiation.
Topics: Alanine; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Escherichia coli; Formaldehyde; Formates; Genetic Code; Guanine Nucleotides; Guanosine Triphosphate; Methionine; Peptide Biosynthesis; Peptide Chain Initiation, Translational; Ribosomes; RNA, Bacterial; RNA, Transfer; RNA, Viral; Serine; Tritium | 1972 |
Kinetic studies on the regulation of rabbit liver pyruvate kinase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Allosteric Regulation; Animals; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Fructosephosphates; Guanosine Triphosphate; Hexosediphosphates; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Liver; Magnesium; Phosphoenolpyruvate; Potassium; Pyruvate Kinase; Rabbits; Spectrophotometry, Ultraviolet | 1973 |
Translation of the initial codons of satellite tobacco necrosis virus ribonucleic acid in a cell-free system from wheat embryo.
Topics: Adenosine Triphosphate; Alanine; Carbon Radioisotopes; Cell-Free System; Centrifugation, Density Gradient; Chlortetracycline; Chromatography, Paper; Dipeptides; Guanosine Triphosphate; Lysine; Magnesium; Methionine; Peptide Chain Initiation, Translational; Peptide Elongation Factors; Peptide Initiation Factors; Plant Cells; Plants; Protein Biosynthesis; Ribosomes; RNA, Messenger; RNA, Transfer; RNA, Viral; Satellite Viruses; Transfer RNA Aminoacylation; Triticum | 1973 |
Cytosolic biosynthesis of GTP and ATP in normal rat pancreatic islets.
Topics: Adenosine Triphosphate; Alanine; Animals; Cytosol; Guanosine Triphosphate; Insulin; Islets of Langerhans; Male; Mercaptopurine; Mycophenolic Acid; Rats; Rats, Sprague-Dawley | 1995 |
Relevance of histidine-84 in the elongation factor Tu GTPase activity and in poly(Phe) synthesis: its substitution by glutamine and alanine.
Topics: Alanine; Amino Acid Sequence; Cloning, Molecular; Escherichia coli; Glutamine; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Histidine; Kinetics; Mutagenesis, Site-Directed; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Point Mutation; Recombinant Proteins | 1995 |
Mechanism of modulation of rat liver fructose-2,6-bisphosphatase by nucleoside triphosphates.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Animals; Arginine; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Kinetics; Liver; Lysine; Molecular Weight; Mutagenesis, Site-Directed; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Point Mutation; Rats; Recombinant Proteins; Sequence Deletion | 1994 |
Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells.
Topics: 3T3 Cells; Alanine; Animals; Cell Line, Transformed; Cell Membrane; Cell-Free System; Enzyme Activation; Guanosine Triphosphate; Insulin; Mice; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Octoxynol; Platelet-Derived Growth Factor; Polyethylene Glycols; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction | 1993 |
Rapid kinetic measurements of second messenger formation in olfactory cilia from channel catfish.
Topics: Alanine; Amino Acids; Animals; Cilia; Cyclic AMP; Cyclic GMP; Cysteine; Epithelium; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Ictaluridae; Inositol 1,4,5-Trisphosphate; Kinetics; Olfactory Mucosa; Second Messenger Systems; Thionucleotides | 1993 |
Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis.
Topics: Alanine; Allosteric Regulation; Animals; Cell Line, Transformed; Chlorocebus aethiops; Dopamine Agonists; Dopamine Antagonists; GTP-Binding Proteins; Guanosine Triphosphate; Hydrogen Bonding; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Dopamine D2; Serine; Spiperone; Structure-Activity Relationship; Transfection | 1996 |
Site-directed mutagenesis of Thermus thermophilus EF-Tu: the substitution of threonine-62 by serine or alanine.
Topics: Alanine; Base Sequence; Binding Sites; DNA Primers; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Elongation Factor Tu; RNA, Transfer, Amino Acyl; Serine; Thermus thermophilus; Threonine | 1995 |
Uncoupling of GTP binding from target stimulation by a single mutation in the transducin alpha subunit.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Diphosphate Ribose; Alanine; Animals; Base Sequence; Cattle; Enzyme Activation; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Molecular Sequence Data; Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Rhodopsin; Transducin | 1996 |
The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Glycine; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Macromolecular Substances; Mice; Molecular Sequence Data; Neurofibromin 1; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Signal Transduction; Structure-Activity Relationship | 1996 |
Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-X-X-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Carbachol; Cell Membrane; CHO Cells; Conserved Sequence; Cricetinae; DNA Primers; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Oxotremorine; Protein Structure, Secondary; Quinuclidinyl Benzilate; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Second Messenger Systems; Transfection | 1996 |
Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Escherichia coli; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanosine Triphosphate; Hydrolysis; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotides; Peptide Fragments; Proto-Oncogene Proteins; Rats; Recombinant Proteins; Threonine | 1995 |
Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Topics: Alanine; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Glycine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Mutation; Phosphates; Protein Conformation; Protein Structure, Secondary | 1996 |
Characterisation of the interaction between guanyl nucleotides and AMPA receptors in rat brain.
Topics: Alanine; Animals; Autoradiography; Brain Chemistry; Excitatory Amino Acid Agonists; Female; Guanine Nucleotides; Guanosine Triphosphate; In Vitro Techniques; Membranes; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Thiocyanates | 1996 |
Cloning and characterization of a dominant-negative vps1 allele of the yeast Saccharomyces cerevisiae.
Topics: Alanine; Alleles; Amino Acid Sequence; Animals; Asparagine; Binding Sites; Carrier Proteins; Cloning, Molecular; Gene Expression Regulation, Fungal; Genes, Fungal; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Mice; Molecular Sequence Data; Rats; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Vesicular Transport Proteins | 1997 |
Identification of amino acid residues of Gsalpha critical to repression of adipogenesis.
Topics: 3T3 Cells; Adipocytes; Alanine; Amino Acid Sequence; Animals; Cell Differentiation; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gs; Guanosine Triphosphate; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship | 1998 |
Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.
Topics: Alanine; Amino Acid Substitution; Animals; Artemia; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-3; Eukaryotic Initiation Factor-5; Fungal Proteins; Guanosine Triphosphate; Hydrolysis; Mammals; Mutagenesis; Nuclear Proteins; Peptide Initiation Factors; Protein Biosynthesis; Rabbits; Rats; Recombinant Fusion Proteins; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2000 |
Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools.
Topics: Adenosine Triphosphate; Alanine; Animals; Antibiotics, Antineoplastic; Antimycin A; Apoptosis; Cell Hypoxia; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Guanosine; Guanosine Triphosphate; Ischemia; Kidney Cortex; Kidney Tubules, Proximal; LLC-PK1 Cells; Male; Models, Biological; Mycophenolic Acid; Necrosis; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Swine | 2000 |
Three-dimensional view of the surface motif associated with the P-loop structure: cis and trans cases of convergent evolution.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Asparagine; Binding Sites; Conserved Sequence; Evolution, Molecular; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Models, Molecular; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Protein Structure, Tertiary; Ribonucleases; Sequence Alignment; Static Electricity; Substrate Specificity | 2000 |
A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Peptide Chain Termination, Translational; Peptide Fragments; Peptide Termination Factors; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine | 2000 |
Alanine scan mutagenesis of the switch I domain of the Caulobacter crescentus CgtA protein reveals critical amino acids required for in vivo function.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Caulobacter crescentus; Guanine; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Mutagenesis, Site-Directed; Phosphorylation; Promoter Regions, Genetic; Xylose | 2001 |
Identification of thermodynamically relevant interactions between EF-Tu and backbone elements of tRNA.
Topics: Alanine; Base Sequence; Binding Sites; Guanosine Triphosphate; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Nuclease Protection Assays; Nucleic Acid Conformation; Peptide Elongation Factor Tu; Phenylalanine; Protein Binding; Protein Conformation; Protons; RNA, Bacterial; RNA, Transfer; RNA, Transfer, Ala; RNA, Transfer, Phe; Thermodynamics; Thermus; Thermus thermophilus | 2001 |
Mutations in the G-domain of elongation factor G from Thermus thermophilus affect both its interaction with GTP and fusidic acid.
Topics: Alanine; Aspartic Acid; Binding Sites; Cell-Free System; Fusidic Acid; Genetic Variation; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Peptide Elongation Factor G; Poly U; Protein Biosynthesis; Protein Structure, Tertiary; Recombinant Proteins; Thermus thermophilus; Threonine | 2001 |
Simultaneous and functional binding of SmpB and EF-Tu-TP to the alanyl acceptor arm of tmRNA.
Topics: Acylation; Alanine; Alanine-tRNA Ligase; Base Sequence; Binding Sites; Electrophoretic Mobility Shift Assay; Escherichia coli; Escherichia coli Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Nuclease Protection Assays; Nucleic Acid Conformation; Peptide Elongation Factor Tu; Protein Binding; Ribonucleases; Ribosomal Proteins; RNA-Binding Proteins; RNA, Bacterial; RNA, Transfer, Amino Acyl | 2001 |
Role of T7 RNA polymerase His784 in start site selection and initial transcription.
Topics: Alanine; Bacteriophage T7; Base Sequence; Binding Sites; DNA-Directed RNA Polymerases; Glutamine; Guanosine; Guanosine Triphosphate; Histidine; Hydrogen Bonding; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Stereoisomerism; Transcription Initiation Site; Viral Proteins | 2002 |
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Carbon-Nitrogen Ligases; Circular Dichroism; Conserved Sequence; Cytidine Triphosphate; Dimerization; Escherichia coli Proteins; Glutamine; Guanosine Triphosphate; Hydrolysis; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed | 2003 |
Visualizing tmRNA entry into a stalled ribosome.
Topics: Alanine; Anticodon; Bacterial Proteins; Codon; Codon, Terminator; Cryoelectron Microscopy; Guanosine Triphosphate; Image Processing, Computer-Assisted; Models, Molecular; Nucleic Acid Conformation; Open Reading Frames; Peptide Elongation Factor Tu; Protein Biosynthesis; Pyridones; Ribosomal Proteins; Ribosomes; RNA-Binding Proteins; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Thermus thermophilus | 2003 |
Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.
Topics: Alanine; Casein Kinase II; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; Enzyme Inhibitors; G1 Phase; Gene Expression; Guanosine Triphosphate; HeLa Cells; Humans; I-kappa B Proteins; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; NF-KappaB Inhibitor alpha; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; RNA; RNA-Binding Proteins; S Phase; Structure-Activity Relationship; Threonine; Transfection; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2003 |
Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alanine; Amino Acid Substitution; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cysteine; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Hydrolysis; Kinetics; Mutation; Pertussis Toxin; Protein Binding; Protein Subunits; RGS Proteins; Thermodynamics; Trypsin; Tryptophan | 2004 |
A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.
Topics: Alanine; Amino Acid Sequence; Cholecystokinin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Guanosine Triphosphate; Humans; Ligands; Melanocyte-Stimulating Hormones; Molecular Structure; Narcotics; Oligopeptides; Protein Binding; Pyrenes; Receptors, Melanocortin; Receptors, Opioid, delta; Stereoisomerism | 2004 |
Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis.
Topics: Adenoviridae; Alanine; Baculoviridae; Binding Sites; Chromatography, Gel; Clathrin; Dynamins; Endocytosis; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Lipids; Models, Chemical; Mutation; Oligonucleotides; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Temperature; Threonine; Time Factors; Transferrin | 2004 |
Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.
Topics: Alanine; Amino Acid Sequence; Codon, Initiator; DNA-Binding Proteins; Eukaryotic Initiation Factor-1; Eukaryotic Initiation Factor-3; Eukaryotic Initiation Factor-5; Gene Expression Regulation, Fungal; Guanosine Triphosphate; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Phenotype; Prokaryotic Initiation Factor-3; Protein Binding; Protein Biosynthesis; Protein Kinases; Protein Structure, Quaternary; Protein Subunits; Ribosomes; RNA, Transfer, Met; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2004 |
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
Topics: Alanine; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Crystallography; Glycine; Guanosine Diphosphate; Guanosine Triphosphate; Mice; NIH 3T3 Cells; Oncogene Protein p21(ras); Oocytes; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Xenopus | 2005 |
Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity.
Topics: Adenylyl Cyclases; Alanine; Animals; Baculoviridae; Cell Line; Cell Membrane; Cysteine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanidine; Guanosine Triphosphate; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; Humans; Mutation, Missense; Receptors, Histamine H2; Recombinant Fusion Proteins; Species Specificity; Spodoptera; Transfection | 2007 |
The site for the allosteric activator GTP of Escherichia coli UMP kinase.
Topics: Alanine; Allosteric Regulation; Amino Acid Substitution; Arginine; Binding Sites; Enzyme Activation; Escherichia coli; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histidine; Mutagenesis; Mutation; Nucleoside-Phosphate Kinase; Protein Conformation; Uridine Triphosphate | 2009 |
A sequence element that tunes Escherichia coli tRNA(Ala)(GGC) to ensure accurate decoding.
Topics: Alanine; Anticodon; Base Sequence; Codon; Conserved Sequence; Escherichia coli; Guanosine Triphosphate; Kinetics; Models, Molecular; Point Mutation; Protein Biosynthesis; RNA, Transfer, Ala | 2009 |
Mutational analysis of the GTP-binding motif of FlhF which regulates the number and placement of the polar flagellum in Vibrio alginolyticus.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Cell Polarity; DNA Mutational Analysis; Flagella; Green Fluorescent Proteins; Guanosine Triphosphate; Immunoprecipitation; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Movement; Mutant Proteins; Mutation; Plasmids; Protein Binding; Protein Transport; Recombinant Fusion Proteins; Vibrio alginolyticus | 2009 |
Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.
Topics: Alanine; Amino Acid Sequence; Blood Platelets; Calcium Signaling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; HEK293 Cells; Humans; Immunoprecipitation; Mass Spectrometry; Molecular Sequence Data; Mutation; Phosphorylation; Plasmids; Platelet Aggregation; rab1 GTP-Binding Proteins; Sequence Homology, Amino Acid; Signal Transduction | 2013 |
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).
Topics: Alanine; Amino Acid Sequence; Animals; Cell Line, Tumor; Enzyme Activation; Eukaryotic Initiation Factor-4E; Fibroblasts; Gene Expression Regulation, Enzymologic; Guanosine Triphosphate; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Sirolimus | 2013 |
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Topics: Alanine; Amino Acid Motifs; Animals; Binding Sites; Cells, Cultured; Crystallography, X-Ray; Glycine; Guanosine Triphosphate; HeLa Cells; Humans; Hydrolysis; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Molecular; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation; Neuropeptides; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Ras Homolog Enriched in Brain Protein; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
Topics: Adenosine Monophosphate; Alanine; Alphacoronavirus; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Catalytic Domain; Computational Biology; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Molecular Docking Simulation; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Ribavirin; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sequence Alignment; Sequence Homology, Amino Acid; Sofosbuvir; Thermodynamics; Uridine Triphosphate; Viral Proteins | 2020 |